TAKAHASHI Toshiyuki 高橋利之

Researcher Number	40236302
Other IDs
Affiliation (based on the past Project Information) *help	2002 – 2004: 東京大学, 医学部附属病院, 助手 2000 – 2001: Faculty of Medicine, University of Tokyo, Assistant, 医学部・附属病院, 助手 1999: 東京大学, 医学部・付属病院, 助手 1996 – 1998: 東京大学, 医学部・附属病院, 助手 1996 – 1997: 東京大学, 医学部附属病院, 助手 1992 – 1995: 東京大学, 医学部(病), 助手 1991: 東京大学, 医学部・(病), 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator 心筋細胞 / Ca^<2+> transient / cardiac myocytes / hypoxia-inducible factor 1α / 誘導型一酸化窒素合成酵素 / RT-PCR法 / サイトカイン / pulmonary hypertension / fetal genes / angiotensin II … More / Toll-like receptors / innate immunity / heart failure / Ca^<2+>transient / 心室間相互作用 / 肺高血圧 / 胎児型遺伝子 / アンジオテンシンII / Toll-like受容体 / 自然免疫 / 心不全 / chick embryo / adenosine / lipopolysaccharide / inducible nitric oxide synthase / vascular endothelial growth factor / myocardial ischemia-reperfusion / hypoxia-inducible factor / cDNA クローニング / endothelial PAS protein 1 / RACE法 / ニワトリ胚 / アデノシン / リポ多糖 / 誘導型-酸化窒素合成酵素 / 血管内皮成長因子 / 心筋虚血・再灌流 / Apoptosis / Intracellular Ca^<2+> / Protein kinases / Cytokines / Inducible nitric oxide synthase / Crosstalk / Intracellular signaling pathways / Failing myocardium / 血小板由来成長因子 / 細胞内Ca^<2+> / アポトーシス / 細胞内Ca^<25> / 蛋白キナーゼ / クロストーク / 細胞内情報伝達路 / 不全心筋 / MAP kinase activity / RNA blot analysis / Immediate-early gene expression / Intracellular Ca^<2+>-handling / Myocardial hypertrophy / Metabolic inhibition / Myocardial ischemia / Cardiac myocyte / ノーザン・ブロット解析 / プロテイン・キナーゼ / MAPキナーゼ活性 / RNAブロット解析 / 早期遺伝子発現 / 細胞内Ca^<2+>動態 / 心肥大 / 代謝阻害 / 心筋虚血 / 心筋収縮 / β遮断薬 / 細胞内Ca^<2+>濃度 / neuron-specific enolase / tyrosine hydroxylase / カテコラミン / 培養心室筋細胞 / 陰性変力作用 / 転写紳士 / 一酸化窒素(NO) / 誘導型nitric oxide合成酵素 / Ca^<2+>電流 / 細胞内[Ca^<2+>] / ノーザンブロット解析 / 電筋生理学 / バキュロウイルス / Na^+-Ca^<2+> exchanger … More Except Principal Investigator 心肥大 / 心筋細胞 / Na^+ / cGMP / adrenomedullin / 心筋虚血 / rat / adenovirus / fetal gene program / thyroid hormone receptor / p38 MAK kinase / cardiac hypertrophy / cardiac myocytes / thyroid hormone / 遺伝子発現 / 心不全 / ラット / アデノウィルス / 胎児型遺伝子発現 / 甲状腺ホルモンレセプター / p38 MAPキナーゼ / 甲状腺ホルモン / regulatory protein / cardiac myosin / centrifuge microscope / laser optical trap / in vitro motility asaay / 不全心 / 調節蛋白 / 心筋ミオシン / 遠心顕微鏡 / レーザー光トラップ / in vitro motility assay / RNA blot analysis / Ca^<2+> exchanger / Sarcoplasmic reticulum Ca^<2+>-ATPase / Intracellular Ca^<2+>-handling / Myocardial relaxation / Myocardial hypertrophy / Cardiac myocyte / 筋小胞体Ca^<2+>ーATPase / RNAブロット解析 / 電位依存性Ca^<2+>チャンネル / Na^+-Ca^<2+>交換機構 / RNAプロット解析 / Ca^<2+>交換機構 / 筋小胞体Ca^<2+>-ATPase / 細胞内Ca^<2+>動態 / 心筋弛緩特性 / Klotho 遺伝子 / BTEB2 / ミオシン軽鎖 / 虚血再灌流 / サイトカイン / 動脈硬化 / 転写因子 / 平滑筋細胞 / 単一心筋 / 細胞内カルシウム / 抗不整脈薬 / Na-Ca交換機構 / 虚血選択性 / 血管選択性 / カルシウム拮抗薬 / cAMP / inward calcium current / contractility / calcium transient / indo-1 / cardiac myocyte / 内向きカルシウム電流 / NOS / NO / MAPkinase / 早期遺伝子 / 筋小胞体Ca^<2+>ATPase / in vivo gene transfer / 細胞内カルシウム濃度 / インターロイキン / 一酸化窒素 / MAP kinase / immediate-early gene Less

Research Projects
(17 results)
Co-Researchers
(17 People)

A novel strategy for the treatment of congestive heart failure utilizing thyroid hormone signaling
- Principal Investigator
  
  KINUGAWA Koichiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Roles of innate immunity in genesis of heart failurePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Toshiyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
心血管系の負荷応答と病態形成:遺伝子転写シグナルと病態生理に基づく治療戦略の確立
- Principal Investigator
  
  永井良三
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Analyses of ischemia-induced signals in cardiac myocytesPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Toshiyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo
心筋組織における内在性アドレナリン作動性細胞の同定とその機能的意義の解析Principal Investigator
- Principal Investigator
  
  高橋利之
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
単離心筋細胞に対する虚血、体液因子の影響の研究。-細胞内Ca^<2+>、pH動態を中心にして。
- Principal Investigator
  
  池ノ内浩
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
病的心における抗不整脈薬と血管選択性カルシウム拮抗薬の陰性変力作用の機序について
- Principal Investigator
  
  河本修身
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Crosstalks among the intracellular signaling pathways in the failing myocardiumPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Toshiyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo
サイトカインによる心筋機能抑制作用の分子機構Principal Investigator
- Principal Investigator
  
  高橋利之
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
心筋虚血・再灌流時の心筋細胞障害に関する研究。
- Principal Investigator
  
  池ノ内浩
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
心筋細胞の虚血性ストレスに対する応答ならびに回復に関する分子生物学的機構-培養心筋細胞での代謝阻害及び摘出灌流心での虚血・再灌流による検討
- Principal Investigator
  
  AOYAGI Teruhiko
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
シグナル伝達因子としての心臓由来一酸化窒素合成系に関する研究
- Principal Investigator
  
  平田恭信
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
心筋Na^+-Ca^<2+>exchangerの分子機構-バキュロウイルス発現システムを用いた検討-Principal Investigator
- Principal Investigator
  
  高橋利之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
慢性圧負荷における心筋細胞筋小胞体Ca^<2+>ATPase転写の検討:慢性圧負荷反応領域のin vivo gene injectionによるマッピング及びpromoter結合蛋白(AP1,Sp1)の検討
- Principal Investigator
  
  青柳昭彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The University of Tokyo
Molecular physiological study of contractile element of failing heart
- Principal Investigator
  
  MOMOURA Shin-ichi, 芹澤剛
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo General
Molecular mechanisms underlying myocardial hypertrophy induced by ischemia : correlation between changes in intracellular ion concentration and those in expression of immediate-early genes.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Toshiyuki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo
A correlative study of myocardial relaxation, intracellular Ca^<2+> concentration, expression of the sarcoplasmic reticulum Ca^<2+>-ATPase.
- Principal Investigator
  
  MOMOMURA Shin-ichi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  University of Tokyo

1. KOHMOTO Osami (00261967)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. SERIZAWA Takashi (90143429)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. HARADA Kazumasa

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. MOMOMURA Shin-ichi (10190985)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
5. AOYAGI Teruhiko (10251240)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
6. 池内浩 (10261968)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
7. MATSUI Hiroshi (30282669)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
8. KINUGAWA Koh-ichiro (00345216)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. YAO Atsushi (70372381)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
10. 杉浦清了 (10272551)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 大谷余志 (90203827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 平田恭信 (70167609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 永井良三 (60207975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 世古義規 (30240708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小室一成 (30260483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SHIMIZU Tatsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 早川宏

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAHASHI Toshiyuki 高橋 利之

Research Projects

Co-Researchers

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Roles of innate immunity in genesis of heart failurePrincipal Investigator

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Analyses of ischemia-induced signals in cardiac myocytesPrincipal Investigator

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心筋組織における内在性アドレナリン作動性細胞の同定とその機能的意義の解析Principal Investigator

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Crosstalks among the intracellular signaling pathways in the failing myocardiumPrincipal Investigator

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サイトカインによる心筋機能抑制作用の分子機構Principal Investigator

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心筋Na^+-Ca^<2+>exchangerの分子機構-バキュロウイルス発現システムを用いた検討-Principal Investigator

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TAKAHASHI Toshiyuki 高橋利之