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TAKAHASHI Toshiyuki
高橋 利之
Connect your ORCID iD
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Researcher Number
40236302
Other IDs
Affiliation (based on the past Project Information)
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2002 – 2004: 東京大学, 医学部附属病院, 助手
2000 – 2001: Faculty of Medicine, University of Tokyo, Assistant, 医学部・附属病院, 助手
1999: 東京大学, 医学部・付属病院, 助手
1996 – 1998: 東京大学, 医学部・附属病院, 助手
1996 – 1997: 東京大学, 医学部附属病院, 助手
1992 – 1995: 東京大学, 医学部(病), 助手
1991: 東京大学, 医学部・(病), 助手
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine
/
Circulatory organs internal medicine
Keywords
Principal Investigator
心筋細胞 / サイトカイン / RT-PCR法 / 誘導型一酸化窒素合成酵素 / hypoxia-inducible factor 1α / cardiac myocytes / Ca^<2+> transient / Na^+-Ca^<2+> exchanger / バキュロウイルス / 電筋生理学
…
More
/ ノーザンブロット解析 / 細胞内[Ca^<2+>] / Ca^<2+>電流 / 誘導型nitric oxide合成酵素 / 一酸化窒素(NO) / 転写紳士 / 陰性変力作用 / 培養心室筋細胞 / カテコラミン / tyrosine hydroxylase / neuron-specific enolase / 細胞内Ca^<2+>濃度 / β遮断薬 / 心筋収縮 / 心筋虚血 / 代謝阻害 / 心肥大 / 細胞内Ca^<2+>動態 / 早期遺伝子発現 / RNAブロット解析 / MAPキナーゼ活性 / プロテイン・キナーゼ / ノーザン・ブロット解析 / Cardiac myocyte / Myocardial ischemia / Metabolic inhibition / Myocardial hypertrophy / Intracellular Ca^<2+>-handling / Immediate-early gene expression / RNA blot analysis / MAP kinase activity / 不全心筋 / 細胞内情報伝達路 / クロストーク / 蛋白キナーゼ / 細胞内Ca^<25> / アポトーシス / 細胞内Ca^<2+> / 血小板由来成長因子 / Failing myocardium / Intracellular signaling pathways / Crosstalk / Inducible nitric oxide synthase / Cytokines / Protein kinases / Intracellular Ca^<2+> / Apoptosis / 心筋虚血・再灌流 / 血管内皮成長因子 / 誘導型-酸化窒素合成酵素 / リポ多糖 / アデノシン / ニワトリ胚 / RACE法 / endothelial PAS protein 1 / cDNA クローニング / hypoxia-inducible factor / myocardial ischemia-reperfusion / vascular endothelial growth factor / inducible nitric oxide synthase / lipopolysaccharide / adenosine / chick embryo / 心不全 / 自然免疫 / Toll-like受容体 / アンジオテンシンII / 胎児型遺伝子 / 肺高血圧 / 心室間相互作用 / Ca^<2+>transient / heart failure / innate immunity / Toll-like receptors / angiotensin II / fetal genes / pulmonary hypertension
…
More
Except Principal Investigator
心筋細胞 / 心肥大 / 心筋虚血 / adrenomedullin / cGMP / Na^+ / immediate-early gene / MAP kinase / 一酸化窒素 / インターロイキン / 細胞内カルシウム濃度 / in vivo gene transfer / 筋小胞体Ca^<2+>ATPase / 早期遺伝子 / MAPkinase / NO / NOS / 内向きカルシウム電流 / cardiac myocyte / indo-1 / calcium transient / contractility / inward calcium current / cAMP / カルシウム拮抗薬 / 血管選択性 / 虚血選択性 / Na-Ca交換機構 / 抗不整脈薬 / 細胞内カルシウム / 単一心筋 / 平滑筋細胞 / 転写因子 / 動脈硬化 / サイトカイン / 虚血再灌流 / ミオシン軽鎖 / BTEB2 / Klotho 遺伝子 / 心筋弛緩特性 / 細胞内Ca^<2+>動態 / 筋小胞体Ca^<2+>-ATPase / Ca^<2+>交換機構 / RNAプロット解析 / Na^+-Ca^<2+>交換機構 / 電位依存性Ca^<2+>チャンネル / RNAブロット解析 / 筋小胞体Ca^<2+>ーATPase / Cardiac myocyte / Myocardial hypertrophy / Myocardial relaxation / Intracellular Ca^<2+>-handling / Sarcoplasmic reticulum Ca^<2+>-ATPase / Ca^<2+> exchanger / RNA blot analysis / in vitro motility assay / レーザー光トラップ / 遠心顕微鏡 / 心筋ミオシン / 調節蛋白 / 不全心 / in vitro motility asaay / laser optical trap / centrifuge microscope / cardiac myosin / regulatory protein / 甲状腺ホルモン / p38 MAPキナーゼ / 甲状腺ホルモンレセプター / 胎児型遺伝子発現 / アデノウィルス / ラット / 心不全 / 遺伝子発現 / thyroid hormone / cardiac myocytes / cardiac hypertrophy / p38 MAK kinase / thyroid hormone receptor / fetal gene program / adenovirus / rat
Less
Research Projects
(
17
results)
Co-Researchers
(
17
People)
Project Start Year (Newest)
Project Start Year (Oldest)
A novel strategy for the treatment of congestive heart failure utilizing thyroid hormone signaling
Principal Investigator
KINUGAWA Koichiro
Project Period (FY)
2003 – 2004
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
Roles of innate immunity in genesis of heart failure
Principal Investigator
Principal Investigator
TAKAHASHI Toshiyuki
Project Period (FY)
2002 – 2003
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
心血管系の負荷応答と病態形成:遺伝子転写シグナルと病態生理に基づく治療戦略の確立
Principal Investigator
永井 良三
Project Period (FY)
2000 – 2002
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
Analyses of ischemia-induced signals in cardiac myocytes
Principal Investigator
Principal Investigator
TAKAHASHI Toshiyuki
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
Circulatory organs internal medicine
Research Institution
University of Tokyo
心筋組織における内在性アドレナリン作動性細胞の同定とその機能的意義の解析
Principal Investigator
Principal Investigator
高橋 利之
Project Period (FY)
1998
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
単離心筋細胞に対する虚血、体液因子の影響の研究。-細胞内Ca^<2+>、pH動態を中心にして。
Principal Investigator
池ノ内 浩
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
病的心における抗不整脈薬と血管選択性カルシウム拮抗薬の陰性変力作用の機序について
Principal Investigator
河本 修身
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
Crosstalks among the intracellular signaling pathways in the failing myocardium
Principal Investigator
Principal Investigator
TAKAHASHI Toshiyuki
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Circulatory organs internal medicine
Research Institution
University of Tokyo
サイトカインによる心筋機能抑制作用の分子機構
Principal Investigator
Principal Investigator
高橋 利之
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
心筋虚血・再灌流時の心筋細胞障害に関する研究。
Principal Investigator
池ノ内 浩
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
心筋細胞の虚血性ストレスに対する応答ならびに回復に関する分子生物学的機構-培養心筋細胞での代謝阻害及び摘出灌流心での虚血・再灌流による検討
Principal Investigator
AOYAGI Teruhiko
Project Period (FY)
1994
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
シグナル伝達因子としての心臓由来一酸化窒素合成系に関する研究
Principal Investigator
平田 恭信
Project Period (FY)
1994
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
心筋Na^+-Ca^<2+>exchangerの分子機構-バキュロウイルス発現システムを用いた検討-
Principal Investigator
Principal Investigator
高橋 利之
Project Period (FY)
1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
慢性圧負荷における心筋細胞筋小胞体Ca^<2+>ATPase転写の検討:慢性圧負荷反応領域のin vivo gene injectionによるマッピング及びpromoter結合蛋白(AP1,Sp1)の検討
Principal Investigator
青柳 昭彦
Project Period (FY)
1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
The University of Tokyo
Molecular physiological study of contractile element of failing heart
Principal Investigator
MOMOURA Shin-ichi
,
芹澤 剛
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Circulatory organs internal medicine
Research Institution
University of Tokyo General
Molecular mechanisms underlying myocardial hypertrophy induced by ischemia : correlation between changes in intracellular ion concentration and those in expression of immediate-early genes.
Principal Investigator
Principal Investigator
TAKAHASHI Toshiyuki
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
University of Tokyo
A correlative study of myocardial relaxation, intracellular Ca^<2+> concentration, expression of the sarcoplasmic reticulum Ca^<2+>-ATPase.
Principal Investigator
MOMOMURA Shin-ichi
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Circulatory organs internal medicine
Research Institution
University of Tokyo
# of Projects (Dsc)
# of Projects (Asc)
1.
KOHMOTO Osami
(00261967)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
2.
SERIZAWA Takashi
(90143429)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
3.
HARADA Kazumasa
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
4.
MOMOMURA Shin-ichi
(10190985)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
5.
AOYAGI Teruhiko
(10251240)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
6.
池内 浩
(10261968)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
7.
MATSUI Hiroshi
(30282669)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
8.
KINUGAWA Koh-ichiro
(00345216)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
9.
YAO Atsushi
(70372381)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
10.
杉浦 清了
(10272551)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
大谷 余志
(90203827)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
平田 恭信
(70167609)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
13.
永井 良三
(60207975)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
14.
世古 義規
(30240708)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
小室 一成
(30260483)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
SHIMIZU Tatsuya
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
早川 宏
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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