Yabe Takeshi 矢部武士

… Alternative Names

YABE Takeshi 矢部武士

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Researcher Number	40239835
Other IDs
Affiliation (Current)	2025: 摂南大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2023: 摂南大学, 薬学部, 教授 2013: 北里大学, 大学院感染制御科学府, 講師 2012: 北里大学, 北里生命科学研究所, 講師 2011: 北里大学, 大学院感染制御科学府, 講師 2008 – 2011: Kitasato University, 大学院・感染制御科学府, 講師 … More 2010: 北里大学, 北里生命科学研究所, 講師 2007 – 2008: Kitasato University, Graduate School of Infection Control Sciences, Lecturer 2005 – 2006: 北里大学, 北里生命科学研究所, 専任講師 1996 – 1997: 社団法人北里研究所, 東洋医学総合研究所・基礎研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Basic Section 52010:General internal medicine-related / Basic Section 59040:Nutrition science and health science-related / Eating habits / General internal medicine(including psychosomatic medicine) Except Principal Investigator General internal medicine (including Psychosomatic medicine) / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Biological pharmacy
Keywords	Principal Investigator 神経新生 / PEDF / 脳虚血 / 神経保護作用 / うつ様症状 / 葉酸 / うつ / 葉酸欠乏 / うつ様行動 / 漢方薬 … More / 神経細胞死 / アストロサイト / グルタミン酸毒性 / グリア細胞 / 社会性行動異常 / 抗生剤 / 発達障害 / 脳機能 / 食と栄養 / エピゲノム修飾 / フェルラ酸 / 精神 / 脳 / 食品 / 栄養 / ヒストンメチル化 / DNAメチル化 / 海馬 / エピジェネティクス / neuroprotective / microglia / astrocyte / オリゴデンドロサイト / マイクログリア / 加味温胆湯 / 精神疾患 / GDNF / スパイン / グルタミン酸トランスポーター / 神経系前駆細胞 / 色素上皮由来因子 / グリア / GLT-1 / GLAST / PEFDF … More Except Principal Investigator 漢方薬 / オレキシン / 香蘇散 / ChAT / NGF / 抗うつ様効果 / 補中益気湯 / 抗うつ様作用メカニズム / 抗菌薬 / 脳腸相関 / 腸内細菌 / 発達障害 / Polygalae Radix / Kami-untan-to / Alzheimer Disease / アルツハイマー型痴呆 / 遠志 / chAT / 加味温胆湯 / アルツハイマー病 / Neuropeptide Y / Orexin A / neuropeptide Y / 上気道粘膜免疫機構 / オリゴ糖 / 抗炎症作用 / IRAK-M / 粘膜炎 / 制御性分子 / 抗がん剤 / パイエル板 / 小腸上皮細胞 / 上気道粘膜免疫系 / 粘膜炎症 / メソトレキセート / ニューロペプチド / プロテオーム / プロテオーム解析 / 腸上皮細胞 / 粘膜免疫機構 / 液膜小胞 / 神経新生 Less

発育期の環境が引き起こす社会性行動異常に対する漢方薬の有用性に関する基礎的解析Principal Investigator
- Principal Investigator
  
  矢部武士
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Setsunan University
Basic research on kampo therapy for developmental abnormalities of neuropsychiatric functions
- Principal Investigator
  
  Araki Ryota
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Setsunan University
Effects of Food and Nutrition on Brain Function:Principal Investigator
- Principal Investigator
  
  Takeshi Yabe
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Setsunan University
Daily diets acts as a regulator of the brain and mental systems.Principal Investigator
- Principal Investigator
  
  YABE TAKESHI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Eating habits
- Research Institution
  Setsunan University
Effect of kampo medicines on brain functionPrincipal Investigator
- Principal Investigator
  
  YABE TAKESHI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine(including psychosomatic medicine)
- Research Institution
  Setsunan University
Analysis of neuroprotective effect of pigment epithelium derived factorPrincipal Investigator
- Principal Investigator
  
  YABE TAKESHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Setsunan University
  Kitasato University
Elicidation of action mechanism of Hochuekkito through immunomodulation of intestinal epithelial cells
- Principal Investigator
  
  KIYOHARA Hiroaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
Role of orexinergic system in the mechanism underlying an antidepressant-like effect of kososan
- Principal Investigator
  
  ITO Naoki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
Study on clarification of action mechanism of a Kampo medicine, Hochuekkito through immunomodulating exosome
- Principal Investigator
  
  YAMADA Haruki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
Involvement of orexin-A and neuropeptide Y in the antidepressant-like effect of kososan.
- Principal Investigator
  
  ITO Naoki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
The role of PEDF in injured brainPrincipal Investigator
- Principal Investigator
  
  YABE Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
A possible mechanism underlying an antidepressive-like effect of kososan -A association of orexin-A with neurogenesis-
- Principal Investigator
  
  ITO Naoki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Kitasato University
  Kitasato Institute
Analysis of neuroprotective effect of PEDFPrincipal Investigator
- Principal Investigator
  
  YABE Takeshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kitasato University
Studies on anti-dementia effects of Kampo medicines and their active ingredients
- Principal Investigator
  
  YAMADA Haruki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Kitasato Institute

[Journal Article] Methyl Donor Supplementation Prevents a Folate Deficiency-induced Depression-like State and Neuronal Immaturity of the Dentate Gyrus in Mice2022
- Author(s)
  Araki Ryota、Nishida Shoji、Oishi Yui、Tachioka Hayato、Kita Ayami、Yabe Takeshi
- Journal Title
  
  Neuroscience
  
  Volume: 485 Pages: 12-22
- DOI
  10.1016/j.neuroscience.2022.01.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K11637
[Journal Article] Post-weaning folate deficiency induces a depression-like state via neuronal immaturity of the dentate gyrus in mice2020
- Author(s)
  Nishida Shoji、Araki Ryota、Baba Akihiro、Asari Sota、Tachibana Shin、Nakajima Yuki、Iwakumo Arimi、Yabe Takeshi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 143 Issue: 2 Pages: 97-105
- DOI
  10.1016/j.jphs.2020.02.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17J03416, KAKENHI-PROJECT-17K00897
[Journal Article] Kamikihito Ameliorates Lipopolysaccharide-Induced Sickness Behavior <i>via</i> Attenuating Neural Activation, but Not Inflammation, in the Hypothalamic Paraventricular Nucleus and Central Nucleus of the Amygdala in Mice2016
- Author(s)
  R Araki, S Nishida, Y Hiraki, F Li, K Matsumoto, T Yabe
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 39 Issue: 2 Pages: 289-294
- DOI
  10.1248/bpb.b15-00707
- NAID
  130005122364
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460925
[Journal Article] Kamikihito ameliorates tumor‐induced sickness behavior in mice2015
- Author(s)
  R Araki, S Nishida, Y Hiraki, T Yabe
- Journal Title
  
  Traditional & Kampo Medicine
  
  Volume: 2 Issue: 2 Pages: 93-96
- DOI
  10.1002/tkm2.1025
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460925
[Journal Article] Genipin attenuates lipopolysaccharide-induced persistent changes of emotional behaviors and neural activation in the hypothalamic paraventricular nucleus and the central amygdala nucleus.2014
- Author(s)
  Araki R, Hiraki Y, Yabe T
- Journal Title
  
  Eur J Pharmacol.
  
  Volume: 741 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460925
[Journal Article] Modulation of chemokine expression on intestinal epithelial cells by Kampo (traditional Japanese herbal) medicine, Hochuekkito, and its active ingredients2013
- Author(s)
  Sekiya M, Kiyohara H, Maruyama H, Yabe T, Yamada H
- Journal Title
  
  J. Nat. Med.
  
  Volume: 67 Pages: 626-635
- NAID
  40019665918
- Data Source
  KAKENHI-PROJECT-23590895
[Journal Article] Involvement of neuropeptide Y signaling in the antidepressant-like effect and hippocampal cell proliferation induced by kososan, a Kampo medicine, in the stress-induced depression-like model mice2012
- Author(s)
  Ito N., Hori A., Yabe T., Nagai T., Oikawa T., Yamada H. and Hanawa T
- Journal Title
  
  Biol. Pharm. Bull
  
  Volume: 35(10) Pages: 1775-1783
- NAID
  130001872380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790751
[Journal Article] Pigment epithelium-derived factor : chemistry, structure, biology, and applications2012
- Author(s)
  Becerra SP, Dass CR, Yabe T, Crawford SE
- Journal Title
  
  J Biomed Biotechnol
  
  Volume: 2012 Pages: 830975-830975
- DOI
  10.1155/2012/830975
- Data Source
  KAKENHI-PROJECT-23590111
[Journal Article] Modulation of chemokine expression on intestinal epithelial cells by Kampo (traditional Japanese herbal) medicine, Hochuekkito,and its active ingredients2012
- Author(s)
  Michiko Sekiya, Hiroaki Kiyohara, Hiroko Maruyama, Takeshi Yabe, Haruki Yamada
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 2012 Issue: 3 Pages: 1-10
- DOI
  10.1007/s11418-012-0724-1
- NAID
  40019665918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590895
[Journal Article] Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo.2010
- Author(s)
  Yabe T, Hirahara H, Harada N, Ito N, Nagai T, Sanagi T, Yamada H.
- Journal Title
  
  Neuroscience 165(2)
  
  Pages: 522-531
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] PEDF up-regulation induced by memantine, an NMDA receptor antagonist, is involved in increased proliferation of hippocampal progenitor cells.2010
- Author(s)
  Namba T, Yabe T, Gonda Y, Ichikawa N, Sanagi T, Arikawa-Hirasawa E, Mochizuki H, Kohsaka S, Uchino S.
- Journal Title
  
  Neuroscience 167
  
  Pages: 372-383
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] The neuroprotective role of PEDF ; Implication for the therapy of neurological disorders.2010
- Author(s)
  Yabe T
- Journal Title
  
  Current Mol.Med.
  
  Volume: 10 Pages: 259-266
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] Adenoviral gene delivery of pigment epithelium-derived factor (PEDF) protects striatal neurons from quinolinic acid-induced excitotoxicity.2010
- Author(s)
  Sanagi T, Yabe T, Yamada H.
- Journal Title
  
  J.Neuropath.Exp.Neurol. 69
  
  Pages: 224-233
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] The neuroprotective role of PEDF ; Implication for the therapy of neurological disorders.2010
- Author(s)
  Yabe T, Sanagi T, Yamada H.
- Journal Title
  
  Current Mol. Med. 10
  
  Pages: 259-266
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] Ferulic acid induces neural progenitor cell proliferation in vitro and in vivo.2010
- Author(s)
  Yabe T
- Journal Title
  
  Neuroscience
  
  Volume: 165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] A possible mechanism underlying an antidepressive-like effect of kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice.2009
- Author(s)
  Ito N., Yabe T., Nagai T., Oikawa T., Yamada H., Hanawa T.
- Journal Title
  
  Biol.Pharm.Bull. 32(10)
  
  Pages: 1716-1722
- NAID
  130000116932
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790631
[Journal Article] A possible mechanism underlying an antidepressive-like effect of kososan, a Kampo medicine, via the hypothalamic orexinergic system in the stress-induced depression-like model mice.2009
- Author(s)
  Ito N, Yabe T, Nagai T, Oikawa T, Yamada H, Hanawa T.
- Journal Title
  
  Biol.Pharm.Bull. 32(10)
  
  Pages: 1716-1722
- NAID
  130000116932
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus2008
- Author(s)
  Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, Hanawa T.
- Journal Title
  
  Biol.Pharm.Bull. 31(7)
  
  Pages: 1376-1380
- NAID
  110006792106
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation2008
- Author(s)
  Ito N., Yabe T., Gamo Y., Nagai T., Oikawa T., Yamada H. and Hanawa T., I.c.v.
- Journal Title
  
  Neuroscience 157
  
  Pages: 720-732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790463
[Journal Article] Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration.2008
- Author(s)
  Murakami Y, Ikeda Y, Yonemitsu Y, Onimaru M, Nakagawa K, Kohno R, Miyazaki M, Hisatomi T, Nakamura M, Yabe T, Hasegawa M, Ishibashi T, Sueishi K.
- Journal Title
  
  Am.J.Pathol. 173(5)
  
  Pages: 1326-1338
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] Protective role of reactive astrocytes in brain ischemia.2008
- Author(s)
  Li L, Lundkvist A, Andersson D, Wilhelmsson U, Nagai N, Pardo AC, Nodin C, Stahlberg A, Aprico K, Larsson K, Yabe T, Moons L, Fotheringham A, Davies I, Carmeliet P, Schwartz JP, Pekna M, Kubista M, Blomstrand F, Maragakis N, Nilsson M, Pekny M.
- Journal Title
  
  J.Cereb.Blood.Flow.Metab. 28(3)
  
  Pages: 468-481
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation.2008
- Author(s)
  Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, Hanawa T.
- Journal Title
  
  Neuroscience. 157(4)
  
  Pages: 720-732
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] Gene transfer of PEDF attenuates ischemic brain damage in the rat middle cerebral artery occlusion model.2008
- Author(s)
  Sanagi T, Yabe T, Yamada H.
- Journal Title
  
  J.Neurochem. 106(4)
  
  Pages: 1841-1854
- Data Source
  KAKENHI-PROJECT-20590089
[Journal Article] Pigment Epithelium-Derived Factor Induces Pro-survival Genes through CREB and NF-KB Activation in rat cultured Cerebellar Granule Cells : Implication for Its Neuroprotective Effect2005
- Author(s)
  Yabe, T, et. al.
- Journal Title
  
  Neuroscience 133
  
  Pages: 691-700
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590068
[Journal Article] Pigment epithelium-derived factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-kB and CREB.2005
- Author(s)
  Yabe T
- Journal Title
  
  GLIA 50(3)
  
  Pages: 223-234
- Data Source
  KAKENHI-PROJECT-17590068
[Journal Article] Pigment epithelium-derived factor induces pro-inflammatory genes in ne onatal astrocytes through activation of NF-kB and CREB2005
- Author(s)
  Yabe T
- Journal Title
  
  Neuroscience 133(3)
  
  Pages: 691-700
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590068
[Journal Article] Pigment Epithelium-Derived Factor Induces Pro-survival Genes through CREB and NF-kB Activation in rat cultured Cerebellar Granule Cells : Implication for Its Neuroprotective Effect.2005
- Author(s)
  Yabe T
- Journal Title
  
  Neuroscience 133(3)
  
  Pages: 691-700
- Data Source
  KAKENHI-PROJECT-17590068
[Journal Article] Pigment epithelium-derived factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-KB and CREB2005
- Author(s)
  Yabe, T, et. al., Yamada, H
- Journal Title
  
  GLIA 50
  
  Pages: 223-234
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590068
[Journal Article] Pigment Epithelium-Derived Factor Induces Pro-survival Genes through CREB and NF-kB Activation in rat cultured Cerebellar Granule Cells: Implication for Its Neuroprotective Effect2005
- Author(s)
  Yabe T
- Journal Title
  
  GLIA 50(3)
  
  Pages: 223-234
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590068
[Presentation] 幼若期クラリスロマイシン投与マウスの腸内細菌叢と脳内遺伝子発現の解析2023
- Author(s)
  荒木良太、村田彩綺、竹本羽那、平川泰佑、井上亮、喜多絢海、矢部武士
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07119
[Presentation] 幼若期のクラリスロマイシン投与は自閉症スペクトラム障害様行動と樹状突起スパインの形成異常を引き起こす2023
- Author(s)
  竹本羽那、村田彩綺、岡田真依、平川泰佑、石原百華、喜多絢海、荒木良太、矢部武士
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07119
[Presentation] 幼若期クラリスロマイシン投与により自閉症スペクトラム障害様行動を示すマウスの潮解バリア機能の解析2023
- Author(s)
  村田彩綺、竹本羽那、岡田真依、平川泰佑、石原百華、稲永美乃里、尾崎清和、川崎通夫、喜多絢海、荒木良太、矢部武士
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07119
[Presentation] 幼若期クラリスロマイシン投与が腸内細菌叢と大脳皮質遺伝子発現に及ぼす影響の網羅的解析2022
- Author(s)
  大石結、冨永悠季、竹本羽那、村田彩綺、平川泰佑、井上亮、喜多絢海、荒木良太、矢部武士
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K07119
[Presentation] 幼少期のクラリスロマイシン投与は成熟後の自閉症様行動を誘発する2022
- Author(s)
  荒木良太、竹本羽那、村田彩綺、平川泰佑、井上亮、喜多絢海、矢部武士
- Organizer
  第142回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07119
[Presentation] 抗菌薬による発達期の腸内細菌叢の異常と自閉症スペクトラム障害との関連性についての基礎的研究2022
- Author(s)
  荒木良太、井上亮、尾崎清和、稲永美乃里、喜多絢海、矢部武士
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07119
[Presentation] 幼若期クラリスロマイシン投与と自閉症スペクトラム障害様行動に関する基礎的研究2022
- Author(s)
  冨永悠季、大石結、竹本羽那、村田彩綺、平川泰佑、荒木良太、矢部武士
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K07119
[Presentation] 幼少期における抗菌薬の使用と自閉症スペクトラム障害の関連性についての基礎的研究2022
- Author(s)
  荒木良太、大石結、冨永悠季、竹本羽那、村田彩綺、井上亮、喜多絢海、矢部武士
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07119
[Presentation] フェルラ酸の認知症周辺症状（BPSD）改善作用における5-HT1A受容体の関与2020
- Author(s)
  安渕顕、榎本太一、田中翔斗、池谷真里那、東和佳、村瀬仁章、河合健太郎、中谷尊史、荒木良太、矢部武士
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] フェルラ酸は5-HT1A受容体の部分作動薬活性により異常行動を改善する2020
- Author(s)
  荒木良太、榎本太一、田中翔斗、安渕顕、池谷真里那、村瀬仁章、河合健太郎、中谷尊史、矢部武士
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] フェルラ酸は5-HT1A受容体部分作動薬活性により精神機能異常を改善する2019
- Author(s)
  荒木良太、榎本太一、田中翔斗、安渕顕、池谷真里那、村瀬仁章、中谷尊史、矢部武士
- Organizer
  第36回和漢医薬学会学術大会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] グリア細胞株由来神経栄養因子 GDNF の発現を誘導する生薬オンジ成分の探索2019
- Author(s)
  小林佑至、榎本太一、板原倭、林尚迪、稲冨由香、中谷尊史、荒木良太、矢部武士
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 葉酸欠乏によるうつ症状メカニズムの解析 -神経成熟異常およびエピゲノム変動の関与2019
- Author(s)
  西田将治、竹村凌、橘新、浅利颯太、荒木良太、矢部武士
- Organizer
  日本農芸化学会2019年度大会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] フェルラ酸の認知症周辺症状改善作用－5-HT1A受容体の関与－2019
- Author(s)
  安渕顕、田中翔斗、池谷真里那、河合健太郎、荒木良太、矢部武士
- Organizer
  第69回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 葉酸欠乏性の神経成熟異常におけるエピゲノム変動の関与2019
- Author(s)
  橘　新、西田将治、竹村凌、浅利颯太、荒木良太、矢部武士
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 葉酸欠乏により誘発される歯状回の神経成熟異常とうつ様行動におけるDNAメチル化の関連性2018
- Author(s)
  竹村凌、西田将治、浅利颯太、橘新、壺井美里、中村吉孝、荒木良太、矢部武士
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] フェルラ酸のBPSD改善作用に関する基礎的研究2018
- Author(s)
  田中翔斗、和田梨沙、南園友紀、荒井雄樹、村瀬仁章、荒木良太、矢部武士
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 葉酸欠乏性の神経成熟異常におけるDNA/ヒストンメチル化の関与2018
- Author(s)
  西田将治，竹村凌，浅利颯太，橘新，壷井美里，中村吉孝，荒木良太，矢部武士
- Organizer
  第61回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 葉酸欠乏性の神経成熟異常における DNA/ヒストンメチル化の関与2018
- Author(s)
  7.浅利颯太、西田将治、竹村凌、橘　新、荒木良太、矢部武士
- Organizer
  第68回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 漢方薬・天然物由来化合物のセロトニン受容体に対する作用の評価系の構築2018
- Author(s)
  板原倭、平城陽介、土屋友美、小林佑至、荒木良太、矢部武士
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 葉酸欠乏により誘発されるうつ様行動と歯状回における神経細胞の成熟異常2017
- Author(s)
  西田将治、竹中裕子、原田郁代、竹村凌、浅利颯太、橘新、壺井美里、中村吉孝、荒木良太、矢部武士
- Organizer
  第132回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 精神疾患モデル動物の異常行動に対するフェルラ酸の作用2017
- Author(s)
  和田梨沙、小松原靖二郎、高橋実友、南園友紀、荒井雄樹、田中翔斗、村瀬仁章、荒木良太、矢部武士
- Organizer
  第67回日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] 生薬オンジの脳機能改善作用のメカニズム解析2017
- Author(s)
  公文早苗、高橋実友、小松原靖二郎、吉田栞、宮本彩海、南園友紀、和田梨沙、板原倭、稲冨由香、荒木良太、矢部武士
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26460925
[Presentation] 葉酸欠乏により誘発されるうつ様行動と海馬における神経細胞の成熟異常2017
- Author(s)
  西田将治、竹中裕子、原田郁代、竹村凌、浅利颯太、橘新、壺井美里、中村吉孝、荒木良太、矢部武士
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2017
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] Folate deficiency-induced depression-like behavior, DNA hypomethylation and abnormal neuronal maturation in mice.2017
- Author(s)
  Shoji Nishida, Yuko Takenaka, Ikuyo Harada, Ryo Takemura, Sota Asari, Shin Tachibana, Misato Tsuboi, Yoshitaka Nakamura, Ryota Araki, Takeshi Yabe
- Organizer
  第60回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17K00897
[Presentation] エピジェネティクスに注目した漢方薬、生薬の脳・精神機能改善作用のメカニズム解析2016
- Author(s)
  荒木良太、矢部武士
- Organizer
  天然薬物研究方法論アカデミー第19回岡崎シンポジウム生理学研究所研究会天然薬物研究方法を考える若手の会
- Place of Presentation
  生理学研究所
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-26460925
[Presentation] コルチコステロン慢性負荷による脳機能障害に対する帰脾湯、オンジエキスの作用2016
- Author(s)
  高橋実友、岡本玖美、上川床友望、小松原靖二郎、南園友紀、和田梨沙、荒木良太、矢部武士
- Organizer
  第65回日本薬学会近畿支部総会
- Place of Presentation
  大阪薬科大学
- Year and Date
  2016-10-15
- Data Source
  KAKENHI-PROJECT-26460925
[Presentation] Action mechanism and active ingredients in Kampo (Japanese herbal) medicines2013
- Author(s)
  Yamada H, Kiyohara H, Nagai T, Yabe T
- Organizer
  SEE PhytoChemNet Workshop, Medical and Aromatic Plants in South East Europe: Environmental and Socio-Economic Challenges. The role of MAB reserves
- Place of Presentation
  Plovdiv, Bulgaria
- Invited
- Data Source
  KAKENHI-PROJECT-23590895
[Presentation] 補中益気湯のパイエル板免疫機能に対する調節作用の解析2012
- Author(s)
  関谷路子、清原寛章、矢部武士、丸山弘子、山田陽城
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] 補中益気湯のパイエル板免疫機能に対する調節作用の解析2012
- Author(s)
  関谷路子、清原寛章、矢部武士、丸山弘子、山田陽城
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道(日本薬学会第132年会要旨集3 p.83)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23590895
[Presentation] 補中益気湯のパイエル板免疫機能に対する調節作用の解析2012
- Author(s)
  関谷路子、清原寛章、矢部武士、丸山弘子、山田陽城
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23590895
[Presentation] 抗菌タンパク発現増強剤としての補中益気湯2011
- Author(s)
  関谷路子、清原寛章、矢部武士、山田陽城
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] 補中益気湯の腸管免疫系に対する作用と作用成分2011
- Author(s)
  清原寛章、関谷路子、永井隆之、矢部武士、山田陽城
- Organizer
  第32回富山大学和漢医薬学総合研究所特別セミナー(招待講演)
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-23590895
[Presentation] 補中益気湯の抗菌C-typeレクチンタンパク誘導賦活化成分2011
- Author(s)
  西本裕紀、関谷路子、清原寛章、矢部武士、山田陽城
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] Recent progress on pharmacological evaluation of Kampo medicines for clinical application and new drug development2011
- Author(s)
  Yamada H, Kiyohara H, Nagai T, Yabe T
- Organizer
  2011 American Society of Pharmacognosy Annual Meeting
- Place of Presentation
  San Diego
- Year and Date
  2011-08-01
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] 補中益気湯の水溶性腸上皮細胞免疫機能調節成分の解析2011
- Author(s)
  西本裕紀、関谷路子、清原寛章、矢部武士、山田陽城
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山(J. Trad. Med. 28 (supple) p.90)
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-23590895
[Presentation] 補中益気湯の水溶性腸上皮細胞免疫機能調節成分の解析2011
- Author(s)
  西本裕紀、関谷路子、清原寛章、矢部武士、山田陽城
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-23590895
[Presentation] 補中益気湯の水溶性腸上皮細胞免疫機能調節成分の解析2011
- Author(s)
  西本裕紀、関谷路子、清原寛章、矢部武士、山田陽城
- Organizer
  第28回和漢医薬学会学術大会
- Place of Presentation
  富山
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] 和漢薬からの腸上皮細胞免疫機能調節成分の探索2010
- Author(s)
  西本裕紀, 関谷路子, 清原寛章, 矢部武士, 山田陽城
- Organizer
  第23回バイオサイエンスフォーラム
- Place of Presentation
  青森
- Year and Date
  2010-08-05
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] 粘膜免疫機構の制御からの漢方薬の薬効解析-補中益気湯を例にして-2010
- Author(s)
  清原寛章, 関谷路子, 永井隆之, 矢部武士, 山田陽城
- Organizer
  第13回天然薬物研究方法論アカデミー覚王山シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2010-08-22
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] 補中益気湯の腸上皮細胞免疫機能調節成分の解析2010
- Author(s)
  西本裕紀, 関谷路子, 清原寛章, 矢部武士, 山田陽城
- Organizer
  第27回和漢医薬学会学術大会
- Place of Presentation
  京都
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] Pigment epithelium-derived factor (PEDF) induces glutamate transporters expression in rat cultured astrocytes.2010
- Author(s)
  畑憲太郎, 佐柳友規, 矢部武士, 山田陽城
- Organizer
  第53回日本神経化学会大会(Neuro2010)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590089
[Presentation] 腸上皮細胞におけるパターン認識分子発現に対する補中益気湯の作用2010
- Author(s)
  関谷路子, 清原寛章, 矢部武士, 山田陽城
- Organizer
  第27回和漢医薬学会学術大会
- Place of Presentation
  京都
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] Pigment Epithelium-Derived Factor (PEDF)によるグルタミン酸トランスポーター発現増強作用の解析2010
- Author(s)
  畑憲太郎、佐柳友規、矢部武士、山田陽城
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-20590089
[Presentation] Pigment epithelium-derived factor (PEDF) induces glutamate transporters expression in rat cultured astrocytes2010
- Author(s)
  Takeshi Yabe
- Organizer
  第53回日本神経化学会大会
- Place of Presentation
  San Diego, USA
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20590089
[Presentation] 漢方薬の作用メカニズムの解析から学ぶこと2010
- Author(s)
  山田陽城、清原寛章、永井隆之、松本司、矢部武士
- Organizer
  第18回天然薬物の開発と応用シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] メマンチンにより発現が亢進するPEDFは成体海馬神経新生の促進に関与する2009
- Author(s)
  難波隆志, 前川素子, 矢部武士, 湯浅茂樹, 内野茂夫, 高坂新一
- Organizer
  第32回日本神経科学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20590089
[Presentation] 腸上皮細胞の免疫機能に対する補中益気湯の作用の解析2009
- Author(s)
  関谷路子, 清原寛章, 矢部武士, 山田陽城
- Organizer
  第26回和漢医薬学会学術大会
- Place of Presentation
  千葉
- Year and Date
  2009-08-30
- Data Source
  KAKENHI-PROJECT-21590772
[Presentation] PEDF protects against ischemic injury in the rat middle cerebral artery occlusion model2008
- Author(s)
  Takeshi Yabe
- Organizer
  Neuroscience 2008.
- Place of Presentation
  Washington, DC
- Data Source
  KAKENHI-PROJECT-20590089
[Presentation] 網膜変性モデル動物におけるpigment epithelium-derived factor (PEDF)の作用に関する病態学的検討2008
- Author(s)
  村上祐介、鬼丸満穂、米満吉和、中川和憲、池田康博、中村誠、矢部武士、長谷川護、石橋達朗、居石克夫
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  金沢市
- Data Source
  KAKENHI-PROJECT-20590089
[Presentation] 一過性脳虚血に対するPEDFの脳保護作用2008
- Author(s)
  矢部武士
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-20590089
[Presentation] PEDF protects against ischemic injury in the rat middle cerebral artery occlusion model2008
- Author(s)
  矢部武士, 佐柳友規, 山田陽城
- Organizer
  北米神経科学会
- Place of Presentation
  Washington DC, U.S.A
- Data Source
  KAKENHI-PROJECT-20590089
[Presentation] Changes in pigment epithelium-derived factor expression following kainic acid induced cerebellar lesion2007
- Author(s)
  Sanagi T, Yabe T, et. al.
- Organizer
  Neuroacience 2007(北米神経科学会)
- Place of Presentation
  San Diego Convention Center
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-17590068
[Presentation] Neuroprotective Effect of Pigment Epithelium-derived Factor (PEDF) Delivered via Adenoviral Vector in the Quinolinic Acid Rat Model of Huntington's Disease effect2005
- Author(s)
  Takeshi Yabe
- Organizer
  Society for Neuroscience 34TH Annual Meeting
- Place of Presentation
  Washington DC
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590068

1. YAMADA Haruki (60096691)

# of Collaborated Projects: 8 results

# of Collaborated Products: 25 results
2. Araki Ryota (90710682)

# of Collaborated Projects: 5 results

# of Collaborated Products: 30 results
3. NAGAI Takayuki (00172487)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
4. ITO Naoki (00370164)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. HANAWA Toshihiko (40164892)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
6. OIKAWA Tetsuro (10370165)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
7. KIYOHARA Hiroaki (70161601)

# of Collaborated Projects: 3 results

# of Collaborated Products: 19 results
8. MARUYAMA Hiroko (50129269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. TORIZUKA Kazuo (60135035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yabe Takeshi 矢部 武士

YABE Takeshi 矢部 武士

Research Projects

Research Products

Co-Researchers

発育期の環境が引き起こす社会性行動異常に対する漢方薬の有用性に関する基礎的解析Principal Investigator

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Review Section

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Basic research on kampo therapy for developmental abnormalities of neuropsychiatric functions

Principal Investigator

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Review Section

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Effects of Food and Nutrition on Brain Function:Principal Investigator

Principal Investigator

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Review Section

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Daily diets acts as a regulator of the brain and mental systems.Principal Investigator

Principal Investigator

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Effect of kampo medicines on brain functionPrincipal Investigator

Principal Investigator

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Analysis of neuroprotective effect of pigment epithelium derived factorPrincipal Investigator

Principal Investigator

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Elicidation of action mechanism of Hochuekkito through immunomodulation of intestinal epithelial cells

Principal Investigator

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Role of orexinergic system in the mechanism underlying an antidepressant-like effect of kososan

Principal Investigator

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Study on clarification of action mechanism of a Kampo medicine, Hochuekkito through immunomodulating exosome

Principal Investigator

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Involvement of orexin-A and neuropeptide Y in the antidepressant-like effect of kososan.

Principal Investigator

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The role of PEDF in injured brainPrincipal Investigator

Principal Investigator

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A possible mechanism underlying an antidepressive-like effect of kososan -A association of orexin-A with neurogenesis-

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Analysis of neuroprotective effect of PEDFPrincipal Investigator

Principal Investigator

Project Period (FY)

Yabe Takeshi 矢部武士

YABE Takeshi 矢部武士