Mizuguchi Hiroyuki 水口博之

… Alternative Names

水口博之ミズグチヒロユキ

MIZUGUCHI Hiroyuki 水口博之

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Researcher Number	40247838
Other IDs
External Links
Affiliation (Current)	2022: 大阪大谷大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2021: 大阪大谷大学, 薬学部, 教授 2017 – 2018: 大阪大谷大学, 薬学部, 教授 2016: 徳島大学, 大学院医歯薬学研究部(薬学系), 准教授 2015: 徳島大学, 大学院医歯薬学研究部, 准教授 2013: 徳島大学, 大学院ヘルスバイオサイエンス研究部, 准教授 … More 2012: 徳島大学, ヘルスバイオサイエンス研究部, 准教授 2010 – 2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 2008: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 2002 – 2003: 大阪医科大学, 医学部, 助手 1994: 大阪医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Food science / Structural biochemistry / Biological pharmacy Except Principal Investigator Applied pharmacology / 膠原病・アレルギー・感染症内科学 / Science and Engineering / Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator ピリドキサルリン酸 / 部位特異的変異 / 芳香族L-アミノ酸デカルボキシラーゼ / ヒスタミンH1受容体遺伝子 / アレルギー疾患感受性遺伝子 / 転写調節 / 天然医薬 / 天然物医薬 / ヒスタミンH1受容体 / セルフメディケーション … More / アミノ基転移酵素 / ピリドキサル5'リン酸 / シッフ塩基pK_a / 触媒反応機構 / ピリドキサル5^1-リン酸 / ヒスチジノールリン酸アミノ基転移酵素 / グルタミンアミノ基転移酵素 / シッフ塩基 pK_a / Aminotransferase / Pyridoxal 5'-phosphate / Schiff base pK_a / Reaction mechanism / Strain / ヒスタミンH１受容体遺伝子発現シグナル / ステロイドシグナル / PKCδ / Hsp90 / マーキアイン / ステロイド受容体 / GRE / ヒスタミンH1受容体遺伝子発現シグナル / AP-1 / (-)マーキアイン … More Except Principal Investigator アレルギー性鼻炎 / アレルギー / 疾患感受性遺伝子 / ヒスタミンH1受容体 / pKa / ヒスタミン受容体 / 遺伝子発現 / ヒスタミンH_1受容体 / 鼻過敏症 / IL-4 / 天然物医薬 / 初期療法 / 蛋白キナーゼC-δ / スプラタスト / アレルギー疾患感受性遺伝子 / 科学的検証 / 個別化医療 / インターロイキン-4 / ヒスチジン脱炭酸酵素遺伝子 / 抗ヒスタミン薬 / ヒスタミン / ヒスチジン脱炭酸酵素 / グルココルチコイド / ブラウンノルウェイラット / トルエンジイソシアネート / 蛋白キナーゼC / 花粉症 / 好酸球 / IL-33 / プロテインキナーゼC / アレルギー疾患 / PKCδ / 抗アレルギー天然物 / プロトン移動 / 触媒反応機構 / 自由エネルギー / 誘導適合 / 立体化学 / 転移酵素 / コンポジット触媒 / アミノ基転移酵素 / コンフォメーション / スフィンゴ脂質 / ピリドキサールリン酸 / 歪み / proton-transfer / catalytic-mechanism / free-energy / induced-fit / stereochemistry / transferase / composite-biocatalyst / ナローバンドUVB / 光線療法 / 狭帯域中波紫外線 / ヒスタミンH１受容体 / アレルギー性鼻炎モデルラット / LED / 好酸球浸潤 Less

IL-33発現抑制によるアレルギー性鼻炎の好酸球性炎症の抑制：ダニ動物モデル研究
- Principal Investigator
  
  北村嘉章
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  The University of Tokushima
Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA
- Principal Investigator
  
  KITAMURA Yoshiaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  The University of Tokushima
Molecular mechanism of steroids for the suppression of histamine H1 receptor signaling.Principal Investigator
- Principal Investigator
  
  Mizuguchi Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka Ohtani University
  The University of Tokushima
Natural medicine-derived suppressor of IL-33 gene expression correlated with eosinophilia
- Principal Investigator
  
  FUKUI Hiroyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The University of Tokushima
Exploring natural resources-derived compounds that suppress up-regulation of histamine H1 receptor gene expression as a diseases-sensitive genePrincipal Investigator
- Principal Investigator
  
  MIZUGUCHI Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Food science
- Research Institution
  The University of Tokushima
Novel reatment method targeting the mechanism of histamineH_1 receptor gene expression
- Principal Investigator
  
  FUKUI Hiroyuki
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  The University of Tokushima
Structure and Function of Histidinol phosphate Aminitrans ferasePrincipal Investigator
- Principal Investigator
  
  MIZUGUCHI Kiroyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka Medical College
Designing composite biocatalysts by analysis of the proton-transfer process in pyridoxal enzymes
- Principal Investigator
  
  HAYASHI Hideyuki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Osaka Medical College
芳香族L-アミノ酸デカルボキシラーゼの構造と機能の解析Principal Investigator
- Principal Investigator
  
  水口博之
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka Medical College

[Book] Handbook of Experimental Pharmacology2016
- Author(s)
  Hiroyuki Fukui, Hiroyuki Mizuguchi, Hisao Nemoto, Yoshiaki Kitamura, Yoshiki Kashiwada and Noriaki Takeda.
- Publisher
  Springer Science, NewYork
- Data Source
  KAKENHI-PROJECT-15K07933
[Book] The Receptors2016
- Author(s)
  Hiroyuki Fukui, Hiroyuki Mizuguchi, Yoshiaki Kitamura and Noriaki Takeda.
- Publisher
  Springer Science, NewYork
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] Effects of Syo-seiryu-to and Its Constituent Crude Drugs on Phorbol Ester-Induced Up-Regulation of IL-33 and Histamine H1 Receptor mRNAs in Swiss 3T3 and HeLa Cells.2021
- Author(s)
  Nakano S, Yamamoto S, Esu T, Naniwa S, Konishi Y, Wakugawa T, Kitamura Y, Fujii T, Kamimura S, Fukui H, Takeda N, Mizuguchi H.
- Journal Title
  
  Allergies
  
  Volume: 1 Pages: 163-175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09693
[Journal Article] Effects of narrow-band UVB on nasal symptom and upregulation of histamine H1 receptor mRNA in allergic rhinitis model rats.2021
- Author(s)
  Seiichiro Kamimura
- Journal Title
  
  Laryngoscope Investig Otolaryngol.
  
  Volume: 8 Pages: 34-41
- DOI
  10.1002/lio2.518
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18254, KAKENHI-PROJECT-20K09693
[Journal Article] Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression2020
- Author(s)
  Nakano Tomohiro、Ikeda Mitsuhiro、Wakugawa Tomoharu、Kashiwada Yoshiki、Kaminuma Osamu、Kitamura Noriko、Yabumoto Masam、Fujino Hiromichi、Kitamura Yoshiaki、Fukui Hiroyuki、Takeda Noriaki、Mizuguchi Hiroyuki
- Journal Title
  
  The Journal of Medical Investigation
  
  Volume: 67 Issue: 3.4 Pages: 289-297
- DOI
  10.2152/jmi.67.289
- NAID
  130007936857
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09693, KAKENHI-PROJECT-18K19561
[Journal Article] Effects of corticosteroid on mRNA levels of histamine H1 receptor in nasal mucosa of healthy participants and HeLa cells2020
- Author(s)
  Kitamura Yoshiaki、Kamimura Seiichiro、Fujii Tatsuya、Mizuguchi Hiroyuki、Naito Keisuke、Kondo Eiji、Matsuda Kazunori、Azuma Takahiro、Sato Go、Fukui Hiroyuki、Takeda Noriaki
- Journal Title
  
  The Journal of Medical Investigation
  
  Volume: 67 Issue: 3.4 Pages: 311-314
- DOI
  10.2152/jmi.67.311
- NAID
  130007936858
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09693
[Journal Article] Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats2018
- Author(s)
  Fujii Tatsuya、Kitamura Yoshiaki、Mizuguchi Hiroyuki、Okamoto Kentaro、Sanada Nanae、Yamada Takuya、Sugiyama Manabu、Michinaga Shotaro、Kitayama Mika、Fukui Hiroyuki、Takeda Noriaki
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 138 Pages: 54-62
- DOI
  10.1016/j.jphs.2018.08.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11214
[Journal Article] Protein kinase C-δ signaling regulates glucagon secretion from pancreatic islets2017
- Author(s)
  Yamamoto K, Mizuguchi H, Tokashiki N, Kobayashi M, Tamaki M, Sato Y, fukui H, Yamauchi A.
- Journal Title
  
  The Journal of Medical Investigation
  
  Volume: 64 Issue: 1.2 Pages: 122-128
- DOI
  10.2152/jmi.64.122
- NAID
  130005501956
- ISSN
  1343-1420, 1349-6867
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07933, KAKENHI-PROJECT-17H04331
[Journal Article] Development of therapeutic strategy target for intracellular signaling molecules responsible for the pathogenesis of allergic diseases2017
- Author(s)
  水口博之
- Journal Title
  
  Folia Pharmacol. Jpn.
  
  Volume: 150 Issue: 4 Pages: 188-194
- DOI
  10.1254/fpj.150.188
- NAID
  130006107981
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] ヒスタミンH1受容体のヒスタミン非依存的活性化による細胞内Ca2+濃度の上昇に対するエピナスチンの抑制作用2017
- Author(s)
  貞方久人、水口博之、福井裕行
- Journal Title
  
  アレルギー・免疫
  
  Volume: 24 Pages: 122-126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathwa2016
- Author(s)
  Shill MC, Mizuguchi H, Karmakar S, Kadota T, Mukherjee PK, Kashiwada Y, Kitamura Y, Nemoto H, Takeda N, Fukui H.
- Journal Title
  
  Int. Immunopharmacol
  
  Volume: 30 Pages: 18-26
- DOI
  10.1016/j.intimp.2015.11.021
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07933, KAKENHI-PROJECT-26350502
[Journal Article] Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats.2016
- Author(s)
  Mizuguchi H, Das AK, Maeyama K, Dev S, Shahriar M, Kitamura Y, Takeda N, Fukui H.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 130 Pages: 212-218
- DOI
  10.1016/j.jphs.2016.02.002
- NAID
  120006556303
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H1 receptor mRNA in HeLa cells.2016
- Author(s)
  Kitamura Y, Mizuguchi H, Okamoto K, Kitayama M, Fujii T, Fujioka A, Matsushita T, Mukai T, Kubo Y, Kubo N, Fukui H, Takeda N.
- Journal Title
  
  Acta Otolaryngol.
  
  Volume: 136 Pages: 409-413
- DOI
  10.3109/00016489.2015.1129555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] 抗アレルギー天然物医薬、苦参の有効成分、(-)マーキアインの分子薬理機構2016
- Author(s)
  福井裕行、水口博之、柏田良樹、根本尚夫、北村嘉章、武田憲昭
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 147 Pages: 148-151
- NAID
  130005131662
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (-)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells.2015
- Author(s)
  Nariai Y, Mizuguchi H, Ogasawara T, Nagai H, Sasaki Y, Okamoto Y, Yoshimura Y, Kitamura Y, Nemoto H, Takeda N, Fukui H.
- Journal Title
  
  J Biol Chem.
  
  Volume: 290 Pages: 27393-27402
- DOI
  10.1074/jbc.m115.657023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression2015
- Author(s)
  Shill MC, Das AK, Itou T, Karmakar S, Mukherjee PK, Mizuguchi H, Kashiwada Y, Fukui H, Nemoto H.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 23 Pages: 6869-6874
- DOI
  10.1016/j.bmc.2015.09.049
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes.2015
- Author(s)
  Mizuguchi H, Nariai Y, Kato S, Nakano T, Kanayama T, Kashiwada Y, Nemoto H, Kawazoe K, Takaishi Y, Kitamura Y, Takeda N, Fukui H.
- Journal Title
  
  Pharmacol Res Perspect
  
  Volume: 3 Pages: 1-13
- DOI
  10.1002/prp2.166
- NAID
  120007027654
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07933
[Journal Article] Usefulness of HeLa cells to evaluate inverse agonistic activity of antihistamines.2013
- Author(s)
  Mizuguchi H
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 15 Pages: 539-543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Usefulness of HeLa cells to evaluate inverse agonistic activity of antihistamines2013
- Author(s)
  Mizuguchi H, Ono S, Hattori M, Sasaki Y, Fukui H
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 15 Pages: 539-543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Quercetin inhibits transcriptional up-regulation of histamine H(1) receptor via suppressing protein kinase C-δ/ extracellular signal- regulated kinase/ poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells2013
- Author(s)
  Hattori M, Mizuguchi H, Baba Y, Ono S, Nakano T, Zhang Q, Sasaki Y, Kobayashi M, Kitamura Y, Takeda N, Fukui H
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 15 Pages: 232-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression2012
- Author(s)
  Mizuguchi H, Ono S, Hattori M, Fukui H
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Pages: 117-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H(1) receptor.2012
- Author(s)
  Mizuguchi H, Miyagi K, Terao T, Sakamoto N, Yamawaki Y, Adachi T, Ono S, Sasaki Y, Yoshimura Y, Kitamura Y, Takeda N, Fukui H
- Journal Title
  
  Sci Rep.
  
  Volume: 2 Pages: 916-916
- DOI
  10.1038/srep00916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen2012
- Author(s)
  Kitamura Y, Mizuguchi H, Ogishi H, Kuroda W, Hattori M, Fukui H, Takeda N
- Journal Title
  
  Acta Otolaryngol
  
  Volume: 132 Pages: 434-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Albizia lebbeck suppresses histamine signaling by the inhibition of histamine H(1) receptor and histidine decarboxylase gene transcriptions2011
- Author(s)
  Nurul IM, Mizuguchi H, Shahriar M, Venkatesh P, Maeyama K, Mukherjee PK, Hattori M, Choudhuri MS, Takeda N, Fukui H
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 11 Pages: 1766-1772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Receptor Gene as an Allergic Diseases-sensitive Gene and Its Impact on Therapeutics for Allergic Diseases.2011
- Author(s)
  Mizuguchi H
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 131 Pages: 171-178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Histamine H(1) Receptor Gene as an Allergic Diseases- sensitive Gene and Its Impact on Therapeutics for Allergic Diseases2011
- Author(s)
  Mizuguchi H, Kitamura Y, Kondo Y, Kuroda W, Yoshida H, Miyamoto Y, Hattori M, Takeda N, Fukui H
- Journal Title
  
  Yakugaku Zasshi
  
  Volume: 131 Pages: 171-178
- NAID
  130000451446
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Transcriptional microarray analysis reveals suppression of histamine signaling by Kujin alleviates allergic symptoms through down-regulation of FAT10 expression2011
- Author(s)
  Dev S, Mizuguchi H, Das AK, Baba Y,Fukui H
- Journal Title
  
  Int Immunopharmacol
  
  Volume: 11 Pages: 1504-1509
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Involvement of Protein Kinase C{delta}/Extracellular Signal-regulated Kinase/Poly(ADP-ribose) Polymerase-1 (PARP-1) Signaling Pathway in Histamine-induced Up-regulation of Histamine H1 Receptor Gene Expression in HeLa Cells2011
- Author(s)
  Mizuguchi H, Terao T,Kitai M, Ikeda M, Yoshimura Y, Das AK, Kitamura Y, Takeda N, Fukui H
- Journal Title
  
  J Biol Chem. 2011
  
  Volume: 286 Pages: 30542-30551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Inverse agonistic activity of antihistamines and suppression of histamine H1 receptor gene expression2011
- Author(s)
  Mizuguchi, H
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Pages: 117-121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Involvement of Protein Kinase C {delta}/Extracellular Signal-regulated Kinase/Poly(ADP-ribose) Poly merase-1 (PARP-1) Signaling Pathway in Histamine-induced Up-regulation of Histamine H1 Receptor Gene Expression in HeLa Cells2011
- Author(s)
  Mizuguchi, H
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 30542-30551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H_1 receptor mRNA in the nasal mucosa of patients with pollinosis.2010
- Author(s)
  Mizuguchi H
- Journal Title
  
  Methods Find Exp Clin Pharmacol
  
  Volume: 32 Pages: 745-758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580132
[Journal Article] Kujin suppresses histamine signaling at transcriptional level in toluene 2, 4-diisocyanate-sensitized rats2009
- Author(s)
  Dev S, Mizuguchi H, Das AK, Maeyama K, Horinaga S, Kato S, Tamada M, Hattori M, Umehara H, Fukui H
- Journal Title
  
  J Pharmacil Sci 109(4)
  
  Pages: 606-617
- NAID
  10025736075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390167
[Journal Article] Sho-seiryu-to suppresses histamine signaling at the trascription level in TDI-sentitized nasal allergy model rats2009
- Author(s)
  Das AK, Mizuguchi H, Kodama M, Dev S, Kitamura Y, Takeda N, Fukui H
- Journal Title
  
  Allergol Int 58(1)
  
  Pages: 81-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390167
[Journal Article] Repeated pre-treatment with antihistamines suppresses transcriptional up-regulations of histamine H_1 receptor and interleukin-4 genes in toluene-2, 4-diisocyanate-sensitized rats.2008
- Author(s)
  Mizuguchi H
- Journal Title
  
  J Pharmacol Sci 108
  
  Pages: 480-486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390167
[Journal Article] Identification of epigallocatechin-3-O-gallate as an active constituent in tea extract that suppresses transcriptional up-regulation of the histamine H_1 receptor and interleukin-4 genes2008
- Author(s)
  Matsushita C, Mizuguchi H, Nino H, Sagesaka Y, Masuyama K, Fukui H.
- Journal Title
  
  J Trad Med 25(5/6)
  
  Pages: 133-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390167
[Journal Article] Suppression of histamine signaling by probiotic Lac-B : a possible mechanism of its anti allergic effect2008
- Author(s)
  Dev S, Mizuguchi H, Matsushita C, Das AK, Maeyama K, Umehara H, Ohtoshi T, Kojima J, Nishida K, Takahashi K, Fukui H.
- Journal Title
  
  J Pharmacol Sci 107(2)
  
  Pages: 159-166
- NAID
  10024320878
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390167
[Journal Article] Repeated pre-treatment with antihistamines suppresses transcriptional up-regulations of histamine H_1 receptor and interleukin-4 genes in toluene-2, 4-diisocyanate-sensitized rats2008
- Author(s)
  Mizuguchi H, Hatano M, Matsushita C, Umehara H, Kuroda W, Kitamura Y, Takeda N, Fukui H.
- Journal Title
  
  J Pharmacol Sci 108(4)
  
  Pages: 480-486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390167
[Journal Article] Stimulation of histamine H_1 receptor up-regulates histamine H_1 receptor itself through activation of receptor gene transcription2007
- Author(s)
  Das AK, Yoshimura S, Mishima R, Fujimoto K, Dev S, Wakayama Y,'Kitamura Y, Horio S, Mizuguchi H, Takeda N, Fukui H.
- Journal Title
  
  J Pharmacol Sci 103(4)
  
  Pages: 374-382
- NAID
  10024313456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390167
[Patent] 鼻過敏症予防・治療剤2012
- Inventor(s)
  福井裕行, 武田憲昭, 水口博之
- Industrial Property Rights Holder
  徳島大学
- Industrial Property Number
  2012-040703
- Filing Date
  2012-02-27
- Data Source
  KAKENHI-PROJECT-22580132
[Patent] 抗アレルギー組成物、抗アレルギー物質セット、及び抗アレルギー物質セットの製造方法2011
- Inventor(s)
  福井裕行、水口博之、武田憲昭
- Industrial Property Rights Holder
  徳島大学
- Industrial Property Number
  2011-011472
- Filing Date
  2011-01-22
- Data Source
  KAKENHI-PROJECT-22580132
[Patent] 鼻粘膜検体内部標準遺伝子2010
- Inventor(s)
  福井裕行、水口博之、武田憲昭
- Industrial Property Rights Holder
  徳島大学
- Industrial Property Number
  2010-258476
- Filing Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22580132
[Patent] アレルギー疾患感受性遺伝子発現抑制物質2010
- Inventor(s)
  福井裕行, 水口博之, 高石喜久, 柏田良樹, 根本尚夫
- Industrial Property Rights Holder
  徳島大学
- Filing Date
  2010-12-15
- Acquisition Date
  2010-06-23
- Overseas
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 抗ヒスタミン薬のインバースアゴニスト作用とヒスタミンH1受容体遺伝子発現抑制効果の検討2021
- Author(s)
  北村嘉章、神村盛一郎、藤井達也、水口博之、福井裕行、武田憲昭
- Organizer
  日本耳鼻咽喉科免疫アレルギー感染症学会
- Data Source
  KAKENHI-PROJECT-20K09693
[Presentation] PUF60, a possible drug discovery target for the therapy of pollinosis, seasonal allergic rhinitis by suppressing NFAT signaling2020
- Author(s)
  Yoshiaki Kitamura, Hiroyuki Mizuguchi, Hiroyuki Fukui, Noriaki Takeda
- Organizer
  JSA/WAO Joint Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09693
[Presentation] アレルギー性鼻炎のヒスタミンH1受容体遺伝子発現亢進機構に対するステロイドの抑制効果の検討2020
- Author(s)
  北村嘉章、神村盛一郎、中野誠一、水口博之、福井裕行、武田憲昭
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-20K09693
[Presentation] Effects of low dose irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA in rat model of allergic rhinitis2018
- Author(s)
  Seiichiro Kamimura, Yoshiaki Kitamura, Tatsuya Fujii, Hiroyuki Mizuguchi, Hiroyuki Fukui, Noriaki Takeda
- Organizer
  27th Congress of the European Rhinologic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11214
[Presentation] 苦参由来抗アレルギー化合物（－）マーキアインのステロイドシグナルへの影響2017
- Author(s)
  岡島菜津希、水口博之、給田愛結美、河井真季子、北村嘉章、武田憲昭、藤野裕道、福井裕行
- Organizer
  第132回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] 膵α細胞からのグルカゴン分泌に関与するPKCアイソザイムの同定2017
- Author(s)
  山本清威、水口博之、渡嘉敷夏海、小林誠、佐藤陽一、藤野裕道、福井裕行、山内あい子
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センターほか（仙台市、宮城県）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] Heat shock protein 90-protein kinase Cdelta; complex as a drug target for the therapy of allergic symptoms2017
- Author(s)
  Hiroyuki Fukui, Hiroyuki Mizuguchi, Yoshiyuki Kitamura, Noriaki Takeda
- Organizer
  第66回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] 苦参由来抗アレルギー化合物(－)マーキアインのステロイドシグナル増強作用2017
- Author(s)
  小笠原健泰、水口博之、給田愛結美、河井真季子、岡島菜津希、藤野裕道、北村嘉章、武田憲昭、福井裕行
- Organizer
  第34回和漢医薬学会
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] 疾患発症シグナルを標的とした花粉症治療戦略2017
- Author(s)
  中野友寛、北村紀子、内田勝幸、福井裕行、神沼　修、水口博之
- Organizer
  第19回応用薬理シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] Treatment with antihistamines in combination with suplatast tosilate markedly alleviated nasal symptoms in toluene-2,4-diisocyanate-sensitized rats.2016
- Author(s)
  Wakugawa T, Mizuguchi H, Kadota T, Sawada A, Kominami T, Kitamura Y, Takeda N, Fukui H.
- Organizer
  The 45th Annual Meeting of the European Histamine Research Society
- Place of Presentation
  フィレンツェ（イタリア）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] アレルギー性鼻炎発症に関与する細胞内シグナルを標的とした治療戦略の開発2016
- Author(s)
  水口博之
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] 小青竜湯によるアレルギー性鼻炎疾患感受性遺伝子発現抑制2016
- Author(s)
  江洲貴子、水口博之、浪花志帆、小西由貴、北村嘉章、武田憲昭、藤野裕道、福井裕行
- Organizer
  第20回日本ヒスタミン学会
- Place of Presentation
  倉敷市立美術館（倉敷市、岡山県）
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] Molecular mechanism of PMA-induced up-regulation of interleukin-33 gene expression and the effect of Sho-seiryu-to on IL-33 and histamine H1 receptor gene expression2016
- Author(s)
  Yoshiaki Kitamura, Takako Esu, Hiroyuki Mizuguchi, Shiho Naniwa,Tatsuya Fujii, Noriaki Takeda, Hiroyuki Fukui
- Organizer
  26th Congress of the European Rhinologic Society
- Place of Presentation
  Stockholm(Sweden)
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11214
[Presentation] 苦参由来抗アレルギー化合物 (-)マーキアインのステロイドシグナルへの影響2016
- Author(s)
  小笠原健泰、水口博之、給田愛結美、河井真季子、岡島菜津希、北村嘉章、武田憲昭、藤野裕道、福井裕行
- Organizer
  第130回日本薬理学会近畿部会
- Place of Presentation
  京都大学（京都市、京都府）
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] Effect of narrow-band UVB on up-regulation of Histamine H1 receptor gene expression.2016
- Author(s)
  Okamoto K, Mizuguchi H, Fujii T, Yamada T, Kitamura Y, Takeda N, Fukui H.
- Organizer
  The 45th Annual Meeting of the European Histamine Research Society
- Place of Presentation
  フィレンツェ（イタリア）
- Year and Date
  2016-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] Clinical significance of antihistamines and kujin, an anti-allergic kampo medicine.2015
- Author(s)
  Fukui H, Esu T, Mizuguchi H, Kitamura Y, Takedea N
- Organizer
  6th International Symposium on Molecular Allergology, ISMA
- Place of Presentation
  Altis Grand Hotel, Lisbon, Portugal
- Year and Date
  2015-11-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07933
[Presentation] Swiss 3T3 細胞におけるイオノマイシン刺激に伴うインターロイキン-33遺伝子発現亢進の分子機構2014
- Author(s)
  山本沙弥香、水口博之、松井恒樹、江洲貴子、北村嘉章、奈邉健、武田憲昭、福井裕行
- Organizer
  日本薬理学会年会
- Place of Presentation
  東北大学百周年記念会館川内萩ホール、仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-24659474
[Presentation] Swiss 3T3細胞におけるイオノマイシン刺激に伴うインターロイキン-33遺伝子発現亢進の分子機構(Molecular mechanism of PMA-induced up-regulation of interleukin-33 gene expression in Swiss 3T3 cells)2014
- Author(s)
  山本沙弥香、水口博之、松井恒樹、江洲貴子、北村嘉章、奈邉健、武田憲昭、福井裕行
- Organizer
  第87回日本薬理学会年会
- Place of Presentation
  東北大学百周年記念会館川内萩ホール、仙台国際センター(宮城県仙台市)
- Data Source
  KAKENHI-PROJECT-24659474
[Presentation] Swiss3T3細胞におけるIL-33遺伝子発現亢進機構2013
- Author(s)
  山本沙弥香、水口博之、松井恒樹、北村嘉章、武田憲昭、福井裕行
- Organizer
  第17回日本ヒスタミン学会
- Place of Presentation
  松江テルサ(島根県松江市)
- Data Source
  KAKENHI-PROJECT-24659474
[Presentation] Swiss3T3細胞におけるIL-33遺伝子発現亢進機構2013
- Author(s)
  山本沙弥香、水口博之、松井恒樹、北村嘉章、武田憲昭、福井裕行
- Organizer
  日本ヒスタミン学会
- Place of Presentation
  松江テルサ（島根県松江市）
- Data Source
  KAKENHI-PROJECT-24659474
[Presentation] 天然物由来抗アレルギー化合物ケルセチンの分子薬理機構2013
- Author(s)
  福井裕行、水口博之、北村嘉章、武田憲昭
- Organizer
  和漢医薬学会学術大会
- Place of Presentation
  金沢大学（石川県金沢市）
- Data Source
  KAKENHI-PROJECT-24659474
[Presentation] タンパクキナーゼCδ シグナル抑制化合物ケルセチンのストレプトゾトシン誘発細胞破壊に対する効果2013
- Author(s)
  水口博之、服部将史、馬場祐子、張倩、小林誠、小野将平、石丸直澄、北村嘉章、武田憲昭、福井裕行
- Organizer
  日本薬学会第133回年会
- Place of Presentation
  パシフィコ横浜 (神奈川県)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Swiss3T3細胞におけるIL-33遺伝子発現亢進機構2013
- Author(s)
  山本沙弥香、水口博之、松井恒樹、北村嘉章、武田憲昭、福井裕行
- Organizer
  日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松山大学（愛媛県松山市）
- Data Source
  KAKENHI-PROJECT-24659474
[Presentation] タンパクキナーゼCδシグナル抑制化合物ケルセチンのストレプトゾトシン誘発β細胞破壊に対する効果2013
- Author(s)
  水口博之
- Organizer
  日本薬学会第133回年会
- Place of Presentation
  パシフィコ横浜　（神奈川県）
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] ケルセチンの分子薬理機構と抗アレルギー作用2013
- Author(s)
  服部将史、水口博之、馬場祐子、北村嘉章、武田憲昭、福井裕行
- Organizer
  日本薬理学会近畿部会
- Place of Presentation
  ウィンクあいち（愛知県名古屋市）
- Data Source
  KAKENHI-PROJECT-24659474
[Presentation] Swiss3T3細胞におけるIL-33遺伝子発現亢進機構2013
- Author(s)
  山本沙弥香、水口博之、松井恒樹、北村嘉章、武田憲昭、福井裕行
- Organizer
  第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松山大学(愛媛県松山市)
- Data Source
  KAKENHI-PROJECT-24659474
[Presentation] 和漢薬苦参はヒスタミンシグナル抑制を介したFAT10/NF-κBシグナルの抑制により抗アレルギー作用を示す2012
- Author(s)
  水口博之, Dev Shrabanti, Das K Asish, 馬場嘉信, 福井裕行
- Organizer
  日本薬学会第132回年会
- Place of Presentation
  北海道大学(北海道)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 天然物由来抗アレルギー化合物を用いた細胞内創薬ターゲットの探索2012
- Author(s)
  水口博之、福井裕行
- Organizer
  第31回分子病理学研究会
- Place of Presentation
  恵那峡グランドホテル(岐阜県)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 苦参由来抗アレルギー性化合物マーキアインの標的タンパク質の同定2012
- Author(s)
  水口博之
- Organizer
  第５１回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  島根県民会館（島根県）
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Exploring the drug targets using natural resources-derived anti-allergic compounds that suppress up-regulation of allergic diseases sensitive gene expression2012
- Author(s)
  Hiroyuki Mizuguchi andHiroyuki Fukui
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] ヒスタミンH1受容体遺伝子発現の分子機構2012
- Author(s)
  水口博之、宮城恒平、寺尾拓馬、坂本典子、山脇洋輔、吉村好之、北村嘉章、武田憲昭、福井裕行
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場(福岡県)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 和漢薬苦参はヒスタミンシグナル抑制を介したFAT10/NF-κBシグナルの抑制により抗アレルギー作用を示す2012
- Author(s)
  水口博之
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(北海道)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 苦参由来抗アレルギー性化合物マーキアインの標的タンパク質の同定2012
- Author(s)
  水口博之、成相祐希、北村嘉章、武田憲昭、福井裕行
- Organizer
  第51回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  島根県民会館(島根県)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] HeLa細胞におけるヒスタミンH1受容体遺伝子発現調節2012
- Author(s)
  水口博之、福井裕行
- Organizer
  第16回日本ヒスタミン学会
- Place of Presentation
  日岡山プラザホテル (岡山県)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] ヒスタミンH１受容体遺伝子発現の分子機構2012
- Author(s)
  水口博之
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡国際会議場（福岡県）
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Heat shock protein 90 is a novel therapeutic target for allergic diseases.2012
- Author(s)
  Mizuguchi
- Organizer
  第４１回日本免疫学会学術集会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Macrophage-derived protein kinase C- is a key molecule for pancreatic -cell destruction in streptozotocin-induced diabetes.2012
- Author(s)
  Hiroyuki Mizuguchi, Masashi Hattori, Asish Kumar Das, Yoshiaki Kitamura, Noriaki Takeda, and Hiroyuki Fukui
- Organizer
  The 2ndKinshukai International Symposium Inflammatory Bowel Diseases: Science, safety, and clinical vcare in IBD
- Place of Presentation
  ホテルニューオオタニ(大阪府)
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] ヒトヒスタミンH1受容体発現シグナルにおけるKu86の関与2012
- Author(s)
  宮城恒平、水口博之、寺尾拓馬、坂本典子、武田憲昭、福井裕行
- Organizer
  第122回日本薬理学会近畿部会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府)
- Year and Date
  2012-11-16
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 天然物由来抗アレルギー化合物を用いた細胞内創薬ターゲットの探索2012
- Author(s)
  水口博之
- Organizer
  第31回分子病理学研究会
- Place of Presentation
  恵那峡グランドホテル（岐阜県）
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] ALBIZIA LEBBECK ALLEVIATED ALLERGY SYMPTOMS BY INHIBITING HISTAMINE SIGNALING AT THE TRANSCRIPTIONAL LEVE2012
- Author(s)
  Yamamoto Sayaka, Hiroyuki Mizuguchi, Nurul Mohammed Islam, Shahriar Masum, Venkatesh Pichairajan, Kazutaka Maeyama, Mukherjee K. Pulok, Hattori Masashi, Choudhuri Sahabuddin Kabir Mohamed, Noriaki Takeda andHiroyuki Fukui
- Organizer
  12thInternational Congress of Ethnopharmacology
- Place of Presentation
  India
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Macrophage-derived protein kinase C-δ is a key molecule for pancreatic β-cell destruction in streptozotocin-induced diabetes.2012
- Author(s)
  Mizuguchi H
- Organizer
  The 2nd Kinshukai International Symposium Inflammatory Bowel Diseases: Science, safety, and clinical vcare in IBD.
- Place of Presentation
  ホテルニューオオタニ（大阪府）
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Exploring the drug targets using natural resources-derived anti-allergic compounds that suppress up-regulation of allergic diseases sensitive gene expression2012
- Author(s)
  水口博之
- Organizer
  第85回日本薬理学会年会シンポジウム
- Place of Presentation
  国立京都国際会館(京都府)(招待講演)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Identification of anti-pollenosis compound in tea extract that suppresses gene expression of histamine H1receptor (H1R)2012
- Author(s)
  Hattori Masashi, Hiroyuki Mizuguchi, Matsushita Chiyo, Niino Hitoshi, Sagesaka Yuko, Masuyama Keisuke andHiroyuki Fukui
- Organizer
  12thInternational Congress of Ethnopharmacology
- Place of Presentation
  India
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] HeLa細胞におけるヒスタミンH1受容体遺伝子発現調節2012
- Author(s)
  水口博之
- Organizer
  第１６回日本ヒスタミン学会
- Place of Presentation
  岡山プラザホテル　（岡山県）
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Ku86はHeLa細胞におけるPMA刺激に伴うヒスタミンH_1受容体の転写亢進を抑制する2011
- Author(s)
  水口博之
- Organizer
  第84会日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 和漢薬苦参はFAT10 遺伝子発現の抑制を介してアレルギー症状を緩和する2011
- Author(s)
  水口博之, S. Dev, Asish K Das, 馬場嘉信, 福井裕行
- Organizer
  第120回日本薬理学会近畿部会
- Place of Presentation
  ホテルグランビア京都(京都府)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 和漢薬苦参はFAT10遺伝子発現の抑制を介してアレルギー症状を緩和する2011
- Author(s)
  水口博之
- Organizer
  第120回日本薬理学会近畿部会
- Place of Presentation
  ホテルグランビア京都(京都府)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] HeLa細胞におけるヒスタミンもしくはPMA刺激に伴うヒスタミンH1受容体の転写亢進の分子機構2011
- Author(s)
  水口博之, 寺尾拓馬, 坂本典子, 山脇洋輔, 吉村好之, 藤本勝巳, 武田憲昭, 福井裕行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  第84回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] アレルギー疾患感受性遺伝子発現亢進抑制作用を有する天然物由来抗アレルギー化合物の標的分子としてのPKCδ2011
- Author(s)
  水口博之
- Organizer
  第84会日本薬理学会年会、シンポジウム
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] HeLa細胞におけるヒスタミンもしくはPMA刺激に伴うヒスタミンH1受容体の転写亢進の分子機構2011
- Author(s)
  水口博之
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府)
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 和漢薬苦参に見出されたアレルギー疾患感受性遺伝子発現抑制作用を有する新規抗アレルギー化合物の同定2010
- Author(s)
  水口博之
- Organizer
  BMB2010、第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] 鼻過敏症ラット鼻粘膜におけるヒスタミンシグナルとサイトカインシグナルのクロストーク2010
- Author(s)
  水口博之
- Organizer
  第118回日本薬理学会近畿部会
- Place of Presentation
  大阪
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22580132
[Presentation] Albizzia lebbeckはtoluene 2, 4-diisocyanate感作アレルギーモデルラットにおいてヒスタミンシグナルを転写レベルで抑制する2009
- Author(s)
  水口博之、Masuni, Shahriar、Mukherjee, Pulok Kumar、福井裕行
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜、横浜市
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] ヒスタミンとIL-4のクロストークを標的とする抗ヒスタミン薬の初期療法の分子機構2009
- Author(s)
  福井裕行、水口博之、堀尾修平、北村嘉章、武田憲昭
- Organizer
  第82回日本薬理学会年会、シンポジウム : アレルギー疾患の背景を形成する免疫・アレルギーネットワークの異常を是正する新規アレルギー疾患治療戦略
- Place of Presentation
  パシフィコ横浜・横浜市
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] (2009) Albizzia lebbeck はtoluene 2, 4-diisocyanate感作アレルギーモデルラットにおいてヒスタミンシグナルを転写レベルで抑制する2009
- Author(s)
  水口博之
- Organizer
  第82回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] エピガロカテキンガレートはヒスタミンH1受容体及びIL-4遺伝子発現を抑制しアレルギー症状を軽減させる2009
- Author(s)
  水口博之. 松下知世, 新納仁, 提坂裕子, 増山敬祐, 福井裕行
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都国際会議場(京都市)
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] 鼻過敏症モデルラットにおける緑茶成分のアレルギー疾患関連遺伝子発現抑制作用2008
- Author(s)
  松下知世、水口博之、新納仁、提坂裕子、福井裕行
- Organizer
  第36回薬物活性シンポジウム/第12回日本ヒスタミン学会
- Place of Presentation
  徳島大学長井記念ホール、徳島市
- Year and Date
  2008-10-23
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] HeLa細胞におけるヒスタミンにより誘導されるヒスタミンH_1受容体遺伝子発現亢進に関与するPKCアイソザイムの同定2008
- Author(s)
  水口博之
- Organizer
  第113回日本薬理学会近畿部会
- Place of Presentation
  ホテルグランビア(岡山市)
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] PMA-induced transcription of histamine H_1 receptor gene in HeLa cells is controlied by multiple transcription factors2008
- Author(s)
  水口博之, 他
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜,横浜市
- Year and Date
  2008-03-19
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] HeLa細胞におけるヒスタミンH_1, 受容体遺伝子発現調節2008
- Author(s)
  水口博之
- Organizer
  第36回薬物活性シンポジウム/第12回日本ヒスタミン学会
- Place of Presentation
  徳島大学長井記念ホール(徳島市)
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] PMA-induced transcription of histamine H_1 receptor gene in HeLa cells is controlled by multiple transcription factors2008
- Author(s)
  水口博之、坂本典子、山脇洋輔、堀尾修平、藤本勝巳、福井裕行
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜、横浜市
- Year and Date
  2008-03-19
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] ヒスタミンH_1受容体刺激により蛋白キナーゼC-δを介して引き起こされるヒスタミンH1受容体遺伝子発現先進2008
- Author(s)
  水口博之
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  国立京都国際会館(京都市)
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] HeLa細胞におけるヒスタミンH_1受容体遺伝子発現調節2008
- Author(s)
  水口博之、福井裕行
- Organizer
  第36回薬物活性シンポジウム/第12回日本ヒスタミン学会
- Place of Presentation
  徳島大学長井記念ホール、徳島市
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] 抗ヒスタミン薬早期投与によるトルエン2 4-ジイソシアネート誘発H_1受容体およびインターロイキン-4遺伝子発現上昇への抑制効果2007
- Author(s)
  秦野昌弥、松下知世、Masum Shahriar、黒田若菜、北村嘉章、Asish Kumar Das、Shrabanti Dev、水口博之、武田憲昭、福井裕行
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場、名古屋市
- Year and Date
  2007-03-15
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] ヒトヒスタミンH_1受容体遺伝子発現調節機構の解明2007
- Author(s)
  水口博之, 他
- Organizer
  BMB2007.第30回日本生物学会年会第80回日本生化学会合同大会
- Place of Presentation
  パシフィコ横浜,横浜市
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18390167
[Presentation] 乳酸菌によるアレルギー性鼻炎改善作用2007
- Author(s)
  松下知世、Shrabanti Dev、Asish K. Das、前山一隆、大利隆行、西田清隆、水口博之、小嶋純、福井裕行
- Organizer
  第11回日本ヒスタミン学会
- Place of Presentation
  富山市民プラザ、富山市
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-18390167

1. FUKUI Hiroyuki (90112052)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
2. TAKEDA Noriaki (30206982)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
3. KITAMURA Yoshiaki (60380028)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
4. MAEYAMA Kazutaka (00157158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. KAWAZOE Kazuyoshi (00248296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KASHIWADA Yoshiki (30169429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NEMOTO Hisao (30208293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. FUJII Tatsuya (00724048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HAYASHI Hideyuki (00183913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YANO Takato (40239827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KURAMITSU Seiki (60153368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KAGAMIYAMA Hiroynki (80028555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 石井誠志 (10247851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 神村盛一郎 (90867194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 佐藤陽一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 神沼修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizuguchi Hiroyuki 水口 博之

水口 博之 ミズグチ ヒロユキ

MIZUGUCHI Hiroyuki 水口 博之

Research Projects

Research Products

Co-Researchers

IL-33発現抑制によるアレルギー性鼻炎の好酸球性炎症の抑制：ダニ動物モデル研究

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Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA

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Molecular mechanism of steroids for the suppression of histamine H1 receptor signaling.Principal Investigator

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Natural medicine-derived suppressor of IL-33 gene expression correlated with eosinophilia

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Exploring natural resources-derived compounds that suppress up-regulation of histamine H1 receptor gene expression as a diseases-sensitive genePrincipal Investigator

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Novel reatment method targeting the mechanism of histamineH_1 receptor gene expression

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Structure and Function of Histidinol phosphate Aminitrans ferasePrincipal Investigator

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Designing composite biocatalysts by analysis of the proton-transfer process in pyridoxal enzymes

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芳香族L-アミノ酸デカルボキシラーゼの構造と機能の解析Principal Investigator

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[Book] Handbook of Experimental Pharmacology2016

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[Book] The Receptors2016

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[Journal Article] Effects of Syo-seiryu-to and Its Constituent Crude Drugs on Phorbol Ester-Induced Up-Regulation of IL-33 and Histamine H1 Receptor mRNAs in Swiss 3T3 and HeLa Cells.2021

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[Journal Article] Effects of narrow-band UVB on nasal symptom and upregulation of histamine H1 receptor mRNA in allergic rhinitis model rats.2021

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[Journal Article] Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression2020

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Mizuguchi Hiroyuki 水口博之

水口博之ミズグチヒロユキ

MIZUGUCHI Hiroyuki 水口博之