YAGI HIDEKI 八木秀樹

ORCID

Connect your ORCID iD *help

… Alternative Names

Researcher Number	40250740
Other IDs
Affiliation (Current)	2021: 国際医療福祉大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2020: 国際医療福祉大学, 薬学部, 教授 2007: Kinki University, School of Pharmacy, Associate Professor 2004 – 2006: Kinki University, School of Pharmaceutical Sciences, Lecturer, Ph, D., 薬学部, 講師 2003: 近畿大学, 薬学部, 助手 2000: 近畿大学, 薬学部, 助手 … More
Review Section/Research Field	Principal Investigator General anatomy (including Histology/Embryology) / 細胞死(アポトーシス) / Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator General anatomy (including Histology/Embryology) / Biological pharmacy / Morphological basic dentistry
Keywords	Principal Investigator Tリンパ球 / CTSマウス / 移出能 / 胸腺 / 免疫不全 / apoptosis / FK506 / nude mouse / scid mouse / 胸線 … More Except Principal Investigator 破骨細胞 / マクロファージ / 胸腺 / 細胞死 / Thymus / Thymocytes / Differentiation / Selection / Clonal deletion / Microenvironment / Apoptosis / Cell death / 好中球 / MMP / ビスフオスフオネート / 赤血球造血 / 顆粒球 / 骨髄 / 脾臓 / アポトーシス誘導剤 / 細胞内カリウムイオン / ジギトキシン / 白血病細胞 / カリウム指示薬 / フローサイトメーター / 強心配糖体 / 抗癌作用 / カリウムイオン / モノクローナル抗体 / ビオチン化 / 胸腺リンパ球 / 分化 / 選択 / クローン排除 / 微小環境 / アポトーシス / apoptosis / pyknosis / 肢芽 / 小腸 / 慢性リウマチ性関節炎 / 骨破壊 / ビスフォスフォネート / コラーゲン誘導関節炎 / エラスターゼ / ビスフォスフォネト / 造血 / Rheumatoid Arthritis / Bone Destruction / Neutrophils / Bisphosphonate / Collagen-induced arthritis / Elastase / メッケル軟骨 / 形態形成 / 自己認識 / Meckel's cartilage / macrophage / Morohogenesis / neutrophil / self-recognition Less

Elucidation of possible mechanisms of lymphatic metastasis noted by a novel lymphangiogenic factorPrincipal Investigator
- Principal Investigator
  
  八木秀樹
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  International University of Health and Welfare
Development of therapeutic monoclonal antibodies aiming at an application and the immunosuppression to an allergic disease of FingolimodPrincipal Investigator
- Principal Investigator
  
  YAGI HIDEKI
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  International University of Health and Welfare
Role of migrating cells for morphogenesis
- Principal Investigator
  
  NAKAMURA Masanori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
ビオチン化抗強心配糖体抗体による抗癌作用の増強
- Principal Investigator
  
  武智昌幸
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Kinki University
Possible mechanisms of induction of apoptosis in enterocytes by intraepithelial lymphocytes.Principal Investigator
- Principal Investigator
  
  YAGI Hideki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  細胞死(アポトーシス)
- Research Institution
  Kinki University
Analysis of the mechanism of bone destruction by neutrophils
- Principal Investigator
  
  NAKAMURA Masanori
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Showa University
  Tohoku University
Mechanisms of pyknotic cell death in vivo and their biological significance
- Principal Investigator
  
  ITOH Tsunetoshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  TOHOKU UNIVERSITY
先天性免疫不全マウス(CTS)の胸腺リンパ球の胸腺難移出性機構の解析Principal Investigator
- Principal Investigator
  
  八木秀樹
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Tohoku University
免疫不全マウス(CTS)の末梢Tリンパ球減少機構の解析-特に胸線の生後発生における変化について-Principal Investigator
- Principal Investigator
  
  八木秀樹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Tohoku University
Microenvironment for thymocyte differentiation, selection and clonal elimination
- Principal Investigator
  
  ITOH Tsunetoshi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Tohoku University
アミノビスフオスフオネートの赤血球造血特にマクロファージへの効果
- Principal Investigator
  
  NAKAMURA Masanori
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Tohoku University
先天性免疫不全マウス(CTS)のTリンパ球減少メカニズムの解析Principal Investigator
- Principal Investigator
  
  八木秀樹
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Tohoku University

All 2020 2019 2018 2017 2016 2008 2004 Other

All Journal Article Presentation

[Journal Article] Changes in histidine decarboxylase expression influence extramedullary hematopoiesis in postnatal mice2020
- Author(s)
  Otsuka Hirotada、Endo Yasuo、Ohtsu Hiroshi、Inoue Satoshi、Kuraoka Mutsuki、Koh Miki、Yagi Hideki、Nakamura Masanori、Soeta Satoshi
- Journal Title
  
  The Anatomical Record
  
  Volume: 304 Pages: 1136-1150
- DOI
  10.1002/ar.24533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07171
[Journal Article] Anti‐tumor effects of mAb against L ‐type amino acid transporter 1 (LAT 1) bound to human and monkey LAT 1 with dual avidity modes2019
- Author(s)
  Ueda Shiho、Hayashi Hidemi、Miyamoto Takako、Abe Shinya、Hirai Kana、Matsukura Kanji、Yagi Hideki、Hara Yuta、Yoshida Kinji、Okazaki Shogo、Tamura Masakazu、Abe Yuki、Agatsuma Toshinori、Niwa Shin‐ichiro、Masuko Kazue、Masuko Takashi
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 674-685
- DOI
  10.1111/cas.13908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-19K07171
[Journal Article] Hypascyrins A-E, Prenylated Acylphloroglucinols from Hypericum ascyron2019
- Author(s)
  Niwa K, Tanaka N, Tatano Y, Yagi H, Kashiwada Y.
- Journal Title
  
  Journal of Natural Products
  
  Volume: 82 Pages: 2754-2760
- DOI
  10.1021/acs.jnatprod.9b00354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10028, KAKENHI-PROJECT-19K07171, KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-17K08337
[Journal Article] 造血組織と骨、ビスフォスフォネートの関与2019
- Author(s)
  中村雅典、八木秀樹、大塚裕忠、遠藤康男
- Journal Title
  
  炎症と免疫
  
  Volume: 27 Pages: 463-468
- Data Source
  KAKENHI-PROJECT-16K08409
[Journal Article] Effects of Zoledronate on Local and Systemic Production of IL-1β, IL-18, and TNF-α in Mice and Augmentation by Lipopolysaccharide2019
- Author(s)
  Funayama Hiromi、Tashima Itaru、Okada Satoru、Ogawa Takuya、Yagi Hideki、Tada Hiroyuki、Wakita Ryo、Asada Yoshinobu、Endo Yasuo
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 42 Issue: 6 Pages: 929-936
- DOI
  10.1248/bpb.b18-00923
- NAID
  130007657675
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11899, KAKENHI-PROJECT-17K11976, KAKENHI-PROJECT-19K07171, KAKENHI-PROJECT-16K08409
[Journal Article] Synthesis of 4′-substituted 2′-deoxy-4′-thiocytidines and its evaluation for antineoplastic and antiviral activities2019
- Author(s)
  Haraguchi K, Kumamoto H, Konno K, Yagi H, Tatano Y, Odanaka Y, Shimbara Matsubayashi S, Snoeck R, Andrei G.
- Journal Title
  
  Tetrahedron
  
  Volume: 75 Pages: 4542-4555
- DOI
  10.1016/j.tet.2019.06.044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10028, KAKENHI-PROJECT-19K07171, KAKENHI-PROJECT-19K17934, KAKENHI-PROJECT-16K08409
[Journal Article] Inhibition of tumor formation and metastasis by a monoclonal antibody against lymphatic vessel endothelial hyaluronan receptor 12018
- Author(s)
  Hara Yuta、Torii Ryota、Ueda Shiho、Kurimoto Erina、Ueda Eri、Okura Hiroshi、Tatano Yutaka、Yagi Hideki、Ohno Yoshiya、Tanaka Toshiyuki、Masuko Kazue、Masuko Takashi
- Journal Title
  
  Cancer Science
  
  Volume: 109 Pages: 3171-3182
- DOI
  10.1111/cas.13755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-17K10028
[Journal Article] Phloroglucinol derivatives and a chromone glucoside from the leaves of Myrtus communis2018
- Author(s)
  Tanaka Naonobu、Jia Yuyu、Niwa Kanji、Imabayashi Kiyoshi、Tatano Yutaka、Yagi Hideki、Kashiwada Yoshiki
- Journal Title
  
  Tetrahedron
  
  Volume: 74 Pages: 117-123
- DOI
  10.1016/j.tet.2017.11.044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08337, KAKENHI-PROJECT-17K10028, KAKENHI-PROJECT-15K19181, KAKENHI-PROJECT-16K08409
[Journal Article] Nitrogen-containing bisphosphonate induces a newly discovered hematopoietic structure in the omentum of an anemic mouse model by stimulating G-CSF production.2017
- Author(s)
  Hirotada Otsuka, Hideki Yagi, Yasuo Endo, Satoshi Soeta, Naoko Nonaka, Masanori Nakamura.
- Journal Title
  
  Cell Tissue Res
  
  Volume: 367 Pages: 297-309
- DOI
  10.1007/s00441-016-2525-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20367, KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-15K11022
[Journal Article] YM155 exerts potent cytotoxic activity against quiescent (G0/G1) multiple myeloma and bortezomib resistant cells via inhibition of survivin and Mcl-1.2017
- Author(s)
  Ookura Miyuki、Fujii Tatsuya、Yagi Hideki、Ogawa Takuya、Kishi Shinji、Hosono Naoko、Shigemi Hiroko、Yamauchi Takahiro、Ueda Takanori、Yoshida Akira
- Journal Title
  
  Oncotarget
  
  Volume: 8 Pages: 111535-111550
- DOI
  10.18632/oncotarget.22871
- NAID
  120006469617
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-16K08410
[Journal Article] Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance2016
- Author(s)
  Takamura, S., H. Yagi, Y. Hakata, C. Motozono, S. R. McMaster, T. Masumoto, M. Fujisawa, T. Chikaishi, J. Komeda, J. Itoh, M. Umemura, A. Kyusai, M. Tomura, T. Nakayama, D. L. Woodland, J. E. Kohlmeier, and M. Miyazawa
- Journal Title
  
  J Exp Med.
  
  Volume: 213 Pages: 3057-3073
- DOI
  10.1084/jem.20160938
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01268, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H05199, KAKENHI-PROJECT-15K19116, KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-16K08821, KAKENHI-PROJECT-16K08850
[Journal Article] Simultaneous induction of apoptotic,autophagic,and necrosis-like cell death by monoclonal antibodies recognizing chicken transferrin receptor2008
- Author(s)
  Ohno Y, Yagi H, Nakamura M., et. al.
- Journal Title
  
  Biochem Biophys Res Commun. 367
  
  Pages: 775-781
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592008
[Journal Article] Simultaneous induction of apoptotic,autophagic,and necrosis-like cell death by monoclonal antibodies recognising chicken transferrin receptor2008
- Author(s)
  Ohno Y., Yagi H., Nakamura M., et. al.
- Journal Title
  
  Biochem Biophys Res Commun. 367・4
  
  Pages: 775-781
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18592008
[Journal Article] Cell-death-inducing monoclonal antibodies raised against DT40 tumor cells : Identification of chicken transferrin receptor as a novel cell-death receptor2008
- Author(s)
  Ohno, Y, Yagi, H, Nakamura, M, Masuko, K, Hashimoto, Y, Masuko, T
- Journal Title
  
  Cancer Sci (in press)
- NAID
  10024005796
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592008
[Journal Article] Simultaneous induction of apoptotic, autophagic, and necrosis-like cell death by monoclonal antibodies recognizing chicken transferrin receptor2008
- Author(s)
  Ohno, Y, Yagi, H, Nakamura, M, Masuko, K, Hashimoto, Y, Masuko, T
- Journal Title
  
  Biochem Biophys Res Commun 367
  
  Pages: 775-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18592008
[Journal Article] Morphological and functional alteration of enterocytes by the daily administration of FK506 : Application of UV-excited alkaline phosphatase substrate, ELF 97 phosphate.2004
- Author(s)
  Yagi, H., et al.
- Journal Title
  
  Cytometry Research 14
  
  Pages: 41-46
- NAID
  10026899552
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603007
[Journal Article] Morphological and functional alteration of enterocytes by the daily administration of FK506:Application of UV-excited alkaline phosphatase substrate, ELF 97 phosphate2004
- Author(s)
  Yagi, H., Hidaka, M.et al.
- Journal Title
  
  Cytometry Research 14
  
  Pages: 41-46
- NAID
  10026899552
- Data Source
  KAKENHI-PROJECT-15603007
[Journal Article] Expression of CD98 amino acid transporter on murine haematopoietic stem cells.2004
- Author(s)
  Yagi, H., et al.
- Journal Title
  
  Cytometry Research 14
  
  Pages: 57-62
- NAID
  10026899700
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15603007
[Journal Article] Expression of CD98 amino acid transporter on murine haematopoietic stem cells2004
- Author(s)
  Yagi, H., Masuko, T.
- Journal Title
  
  Cytometry Research 14
  
  Pages: 57-62
- NAID
  10026899700
- Data Source
  KAKENHI-PROJECT-15603007
[Journal Article] Noimprovement of bone destruction in collagen-induced arthritis by bisphosphonates
- Author(s)
  Nakayama M, Yagi H, Endo Y, Maki K, Nakamura M
- Journal Title
  
  Histology and Histopathology (in press)
- Data Source
  KAKENHI-PROJECT-18592008
[Presentation] ヒトlysophosphatidyl serine受容体に対する新規モノクローナル抗体の作製2020
- Author(s)
  小太刀菜月、高橋健人、桑島みなみ、物江静香、小川拓哉、多田納豊、八木秀樹
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-16K08409
[Presentation] 新規抗ヒトLysoPS受容体モノクローナル抗体作製とその性状解析2020
- Author(s)
  木村朱里、高橋健人、小太刀菜月、桑島みなみ、物江静香、小川拓哉、多田納豊、八木秀樹
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-19K07171
[Presentation] 新規ラットモノクローラル抗体のヒト膵癌組織に対する反応性と抗腫瘍効果2020
- Author(s)
  吉本蒼司、林菜津美、沖田鋼季、八木秀樹、石渡俊行、益子高、遠藤雄一、杉浦麗子
- Organizer
  第79回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07171
[Presentation] 高骨転移性肺癌細胞株由来新規破骨細胞誘導因子の探索2020
- Author(s)
  佐藤將、百百純里奈、常田百合、岩﨑洸、太田智之、松本光史、多田納豊、八木秀樹
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07171
[Presentation] 高骨転移性肺癌細胞株由来新規破骨細胞誘導因子の探索2020
- Author(s)
  佐藤將、百百純里奈、常田百合、岩﨑洸、太田智之、松本光史、多田納豊、八木秀樹
- Organizer
  日本薬学会第140年会（京都）
- Data Source
  KAKENHI-PROJECT-16K08409
[Presentation] 新規ラットモノクローナル抗体のヒト大腸癌に対する抗腫瘍効果2020
- Author(s)
  山崎晶貴、富岡佳久、林菜津美、吉本蒼司、杉浦麗子、沖田鋼季、八木秀樹、八木田秀雄、益子高、遠藤雄一
- Organizer
  第79回日本癌学会
- Data Source
  KAKENHI-PROJECT-19K07171
[Presentation] ヒトlysophosphatidyl serine受容体に対する新規モノクローナル抗体の作製2020
- Author(s)
  小太刀菜月、高橋健人、桑島みなみ、物江静香、小川拓哉、多田納豊、八木秀樹
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07171
[Presentation] フローサイトメトリーによる細胞傷害試験法の開発2019
- Author(s)
  菅井一真、高野みどり、太田智之、常田百合、多田納豊、八木秀樹
- Organizer
  第29回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07171
[Presentation] 高リンパ節転移ヒト乳癌細胞株由来新規リンパ管新生因子の探索2019
- Author(s)
  百百純里奈、池内晶哉、三浦眞今子、常田百合、松本光史、益子高、多田納豊、八木秀樹
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08409
[Presentation] フローサイトメトリーによる細胞傷害試験法の開発2019
- Author(s)
  菅井一真、高野みどり、太田智之、常田百合、多田納豊、八木秀樹
- Organizer
  第29回日本サイトメトリー学会学術集会（東京）
- Data Source
  KAKENHI-PROJECT-16K08409

1. NAKAMURA Masanori (50180394)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
2. ITOH Tsunetoshi (90004746)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MASUKO Takashi (30157200)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. SOGA Hiroyuki (20282121)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KONDO Shintaro (60186848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. EGAWA Kaoru (60119162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NONAKA Naoko (20307052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 武智昌幸 (00140343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TATANO Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. KASHIWADA Yoshiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. TANAKA Naonobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. OTSUKA Hirotada

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TAKAMURA Shiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. TOMURA Michio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. MIYAZAWA Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. WAKITA Ryo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 岡崎章悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 宮澤正顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 中山俊憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 博多義之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 本園千尋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 船山ひろみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 吉田明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results