ONO Katsushige 小野克重

Researcher Number	40253778
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2003 – 2022: 大分大学, 医学部, 教授 2012: 大分大学, 医学部病態生理学講座, 教授 1999: 大分医科大学, 医学部, 教授 1994 – 1998: 大分医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / General physiology / General physiology / Basic Section 48020:Physiology-related Except Principal Investigator General physiology / Thoracic surgery / Thoracic surgery
Keywords	Principal Investigator イオンチャネル / リモデリング / 転写因子 / 心房細動 / 自動拍動 / MEF2C / GATA4 / Nkx2.5 / Csx / 分化心筋 … More / マイクロRNA / カルシウム過負荷 / ion channel / Naチャネル / ペースメーカ / パッチクランプ / カリウム / マグネシウム / 電解質 / 転写 / IK1チャネル / Kir2.1チャネル / Kbp / 電解質 - 転写連関 / K+チャネル / Kbpタンパク / 細胞外カリウム / IK1 / 高カリウム血症 / YgaU / kbp / KCNJ2 / potassium / KAChチャネル / 心房筋 / Ca2+依存性プロテインキナーゼC / アセチルコリン感受性Kチャネル / conventional PKC / アセチルコリン感受性 / miR-30d / IKACh / cell transplantation / pacemaker / regeneration / differentiation / cardio : myocyte / 細胞移植 / 再生 / 分化 / 心筋細胞 / 静止電位 / 活動電位 / 再生心筋 / rabbit / dihydropyridine / CHW Ccells / beta subunit / alpha subunit / subconductance / calcium channel / laeZ / ベータガラクシトダーゼ / ラット心室筋細胞 / lacZ / ベータガラクトシダーゼ / アデノウィルス / Na CHANNEL / beta SUBUNIT / CONDUCTANCE / alpha1 SUBUNIT / Ca CHANNEL / PATCH CLAMP / COS CELL / α_1サブユニット / βサブユニット / コンダクタンス / α1サブユニット / Caチャネル / COS細胞 / マクロRNA / ヒト心筋 / IK.ACh / microRNA / atrial fibrillation / remodeling / electrophysiology / プロテアソーム / Na^+チャネル / 脱ユビキチン / ユビキチン / 細胞内カルシウム過負荷 / 心筋 / Ca過負荷 / 不整脈 / ペースメーカー / 不整脈其質 / 不整脈基質 / Ca^<2+>チャネル / アポトーシス / 心臓病態学 / Ca電流 / Na電流 / 電気生理 / 拒絶 / 心移植 … More Except Principal Investigator イオンチャネル / 心房細動 / 疾患モデルラット / Ａｎｇｉｏｔｅｎｓｉｎ　ＩＩ / microRNA-30d / ミトコンドリア障害 / 遺伝子改変ラット / 細胞内カルシウム / 遺伝子改変動物 / microRNA / 対外循環 / 不整脈 / マイクロRNA / 体外循環 / マイクロ RNA / 不性脈 / 循環器 / 電気生理学 / lacZ / 心移植 / アデノウィルス / イオンチャンネル Less

Mechanisms for extracellular electrolyte-dependent regulation of ion channel expressionPrincipal Investigator
- Principal Investigator
  
  Ono Katsushige
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Oita University
Development of new diagnostic methods for atrial fibrillation based on miR-30d as a baiomarkerPrincipal Investigator
- Principal Investigator
  
  Ono Katsushige
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Oita University
MicroRNA overexpression to establish a new arrhythmia model for studying its molecular mechanism.
- Principal Investigator
  
  MORISHIMA Masaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  The University of Tokushima
  Oita University
Regulation of microRNAs responsible for ion channel remodeling in atrial fibrillationPrincipal Investigator
- Principal Investigator
  
  Ono Katsushige
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Oita University
MicroRNAs Analysis for Investigation of the Causes in Human Atrium Electrical Remodeling
- Principal Investigator
  
  IWATA Eriko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Oita University
Oncogene TRE regulates voltage-gated Na^+ channel remodelingPrincipal Investigator
- Principal Investigator
  
  ONO Katsushige
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Oita University
Investigations on the T-type Ca^<2+> channel as a trigger for cellular Ca^<2+>-overload and clinical insight to regulate cellular apoptosisPrincipal Investigator
- Principal Investigator
 
 ONO Katsushige
- Project Period (FY)
 2007 – 2008
- Research Category
 
 Grant-in-Aid for Scientific Research (C)
- Research Field
 
 Circulatory organs internal medicine
- Research Institution
 Oita University
Research on the development of biopacemaker by use of plnipotent P19CL6 cells.Principal Investigator
- Principal Investigator
  
  ONO Katsushige
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Oita University
Electrophysiological determination of P19CL6-derived cardiomyocytes and their modification by the transcription factor Csx/Nkx2-5Principal Investigator
- Principal Investigator
  
  ONO Katsushige
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Oita University
  大分医科大学
移植心筋へのイオンチャネル遺伝子導入による心臓電気興奮性の制御
- Principal Investigator
  
  穴井博文
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Thoracic surgery
- Research Institution
  大分医科大学
Functional Expression of L-Type Cardiac Calcium Channels in Mammalian Cell in in vivo and in vitro by Use of Adenovirus.Principal Investigator
- Principal Investigator
  
  ONO Katsushige
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  OITA MEDICAL UNIVERSITY
MOLECULAR FUNCTION OF CHIMERIC Ca-Na IONIC CHANNELSPrincipal Investigator
- Principal Investigator
  
  ONO Katsushige
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  OITA MEDICAL UNIVERSITY
移植心の体液性機能調節の再成立に関する電気生理学的研究Principal Investigator
- Principal Investigator
  
  小野克重
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General physiology
- Research Institution
  大分医科大学

[Book] シンプル循環器学2015
- Author(s)
  小野克重
- Total Pages
  447
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-25460292
[Book] アミオダロンの薬理学的特徴と心房細動治療への期待2011
- Author(s)
  小野克重
- Total Pages
  3
- Publisher
  ライフサイエンス社
- Data Source
  KAKENHI-PROJECT-21590934
[Book] 不整脈20112011
- Author(s)
  小野克重
- Total Pages
  10
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-21590934
[Book] Caハンドリング異常と不整脈、ここまで進んだ不整脈研究の最新動向(別冊・医学のあゆみ)2011
- Author(s)
  小野克重
- Total Pages
  7
- Publisher
  医歯薬出版社
- Data Source
  KAKENHI-PROJECT-21590934
[Book] Heart;心臓血管系2011
- Author(s)
  小野克重
- Total Pages
  13
- Publisher
  医学出版社
- Data Source
  KAKENHI-PROJECT-21590934
[Book] 新・心臓病診療プラクティス 7.心電図で診る・治す2006
- Author(s)
  小野克重
- Total Pages
  5
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Book] 別冊・医学のあゆみイオンチャネル最前線update2005
- Author(s)
  小野克重
- Total Pages
  6
- Publisher
  医歯薬出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel.2023
- Author(s)
  Wei M, Wang P, Zhu X, Morishima M, Liu Y, Zheng M, Liu G, Osanai H, Yoshimura K, Kume S, Kurokawa T, Ono K
- Journal Title
  
  PLOS ONE
  
  Volume: 18(2)
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277
[Journal Article] Pharmacological activation of estrogenic receptor G protein coupled receptor 30 attenuates angiotensin II-induced atrial fibrosis in ovariectomized mice by modulating TGF-β1/smad pathway2022
- Author(s)
  Liu D, Zhan Y, Ono K, Yin Y, Wang L, Wei M, Ji L, Liu M, Liu G, Zhou X, Zheng M
- Journal Title
  
  Molecular Biology Reports
  
  Volume: s11033-022-07444-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277
[Journal Article] 2020 JCS/JHRS Guideline on Pharmacotherapy of Cardiac Arrhythmias2022
- Author(s)
  Ono K, Iwasaki Y, Akao M, Ikeda T, et al.
- Journal Title
  
  J Arrhythm
  
  Volume: 38(6) Pages: 833-973
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277
[Journal Article] Protein kinase C regulates expression and function of the Cav3.2 T-type Ca channel during maturation of neonatal rat cardiomyocyte2022
- Author(s)
  Wang Y, Morishima M, Ono K
- Journal Title
  
  Membranes
  
  Volume: 12(7) Issue: 7 Pages: 686-686
- DOI
  10.3390/membranes12070686
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-20K11636
[Journal Article] MiR-223-3p inhibit the progression of atherosclerosis via down-regulating the activation of MEK1/ERK1/2 in macrophages2022
- Author(s)
  Zheng M, You D, Qiao Q, Ono K, Wei M, Tan W, Wang C, Liu Y, Liu G
- Journal Title
  
  Aging
  
  Volume: 14(4) Issue: 4 Pages: 1865-1878
- DOI
  10.18632/aging.203908
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277
[Journal Article] Serum microRNA-30d is a sensitive biomarker for angiotensin II-induced cardiovascular complications in rats2021
- Author(s)
  Morishima M, Ono K
- Journal Title
  
  Heart and Vessels
  
  Volume: 36 Issue: 10 Pages: 1597-1606
- DOI
  10.1007/s00380-021-01853-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-20K11636
[Journal Article] Disruption of asparagine-linked glycosylation to rescue and alter gating of the Nav1.5-Na+ channel2021
- Author(s)
  Wang P, Zhu X, Wei M, Liu Y, Yoshimura K, Zheng M, Liu G, Kume S, Kurokawa T, Ono K
- Journal Title
  
  Heart and Vessels
  
  Volume: 36 Issue: 4 Pages: 589-596
- DOI
  10.1007/s00380-020-01736-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-21K06771, KAKENHI-PROJECT-21K06784, KAKENHI-PROJECT-19K16491
[Journal Article] Manifestationsof gene expression profiles in human right atrial myocardium caused by mechanical stretch2021
- Author(s)
  Suzuki R, Morishima M, Nakada C, Miyamoto S, Ono K
- Journal Title
  
  Heart and Vessels
  
  Volume: 36 Issue: 4 Pages: 577-588
- DOI
  10.1007/s00380-020-01724-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-20K11636
[Journal Article] Nitric oxide down-regulates voltage-gated Na+ channel in cardiomyocytes possibly through S-nitrosylation-mediated signaling2021
- Author(s)
  Wang P, Wei M, Zhu X, Liu Y, Yoshimura K, Zheng M, Liu G, Kume S, Morishima M, Kurokawa T, Ono K
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 11273-11273
- DOI
  10.1038/s41598-021-90840-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-20K11636, KAKENHI-PROJECT-21K06771, KAKENHI-PROJECT-21K06784, KAKENHI-PROJECT-19K16491
[Journal Article] Oxytocin down-regulates the Cav1.2 L-type Ca2+ channel via Gi/cAMP/PKA/CREB signaling pathway in cardiomyocytes2021
- Author(s)
  Morishima M, Tahara S, Wang Y, Ono K
- Journal Title
  
  Membranes
  
  Volume: 11 Issue: 4 Pages: 234-234
- DOI
  10.3390/membranes11040234
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-20K11636
[Journal Article] Enhanced BDNF actions following acute hypoxia facilitate HIF-1α-dependent upregulation of Cav3-T-type Ca2+ channels in rat cardiomyocytes2021
- Author(s)
  Morishima M, Fujita T, Osagawa S, Kubota H, Ono K
- Journal Title
  
  Membranes
  
  Volume: 11 Issue: 7 Pages: 11070470-11070470
- DOI
  10.3390/membranes11070470
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277, KAKENHI-PROJECT-20K11636
[Journal Article] The impact of subclinical hypothyroidism on long-term outcomes in older patients undergoing percutaneous coronary intervention2021
- Author(s)
  Liu YS, Wei M, Wang L, Liu G, Ma GP, Ono K, Cao ZL, Yang M, Zheng MQ
- Journal Title
  
  BMC Endocr Disord
  
  Volume: 21 Issue: 1 Pages: 43-43
- DOI
  10.1186/s12902-021-00702-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277
[Journal Article] Cardiacspecific transcription factor Csx/Nkx2.5 regulates transient-outward K+channel expression in pluripotent P19 cell-derived cardiomyocytes2020
- Author(s)
  Uchino T, Zheng M, Wang Y, Ono K
- Journal Title
  
  J Physiol Sci
  
  Volume: 7 Issue: 1 Pages: 1-7
- DOI
  10.1186/s12576-020-00748-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08498
[Journal Article] Magnesium Deficiency Causes Transcriptional Down-Regulation of Kir2.1 and Kv4.2Channels in Cardiomyocytes Resulting in QT interval Prolongation2020
- Author(s)
  Shimaoka T, Wang Y, Morishima M, Miyamoto S, Ono K
- Journal Title
  
  Circulation Journal
  
  Volume: 6 Pages: 211-215
- NAID
  130007879308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08498
[Journal Article] Short- and long-term roles of phosphatidylinositol 4,5-bisphosphate PIP2 on Cav3.1- and Cav3.2-T-type calcium channel current2019
- Author(s)
  Liu Yangong、Iwano Tomohiro、Ma Fangfang、Wang Pu、Wang Yan、Zheng Mingqi、Liu Gang、Ono Katsushige
- Journal Title
  
  Pathophysiology
  
  Volume: 26 Issue: 1 Pages: 31-38
- DOI
  10.1016/j.pathophys.2018.12.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08498
[Journal Article] Asparagine-linked glycosylation modifies voltage-dependent gating properties of CaV3.1-T-type Ca2+ channel2019
- Author(s)
  Liu Yangong、Wang Pu、Ma Fangfang、Zheng Mingqi、Liu Gang、Kume Shinichiro、Kurokawa Tatsuki、Ono Katsushige
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 69 Issue: 2 Pages: 335-343
- DOI
  10.1007/s12576-018-0650-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08498, KAKENHI-PROJECT-16K08494, KAKENHI-PROJECT-19K16491, KAKENHI-PROJECT-17K15567
[Journal Article] Testosterone-mediated upregulation of delayed rectifier potassium channel in cardiomyocytes causes abbreviation of QT intervals in rats.2018
- Author(s)
  Masuda K, Takanari H, Morishima M, Ma F, Wang Y, Takahashi N, Ono K.
- Journal Title
  
  J Physiol Sci
  
  Volume: Jan 13 Issue: 6 Pages: 1-9
- DOI
  10.1007/s12576-017-0590-4
- NAID
  40021720520
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08498, KAKENHI-PROJECT-15KK0313, KAKENHI-PROJECT-15K08179, KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-16K09964
[Journal Article] Atrial fibrillation-mediated up-regulation of miR-30d regulates myocardial electrical remodeling of G-protein-gated K+ channel, IK.ACh2016
- Author(s)
  Masaki Morishima, Eriko Iwata, Chisato Nakada, Yoshiyuki Tsukamoto, Hiroki Takanari, Shinji Miyamoto,Masatsugu Moriyama,Katsushige Ono
- Journal Title
  
  Circulation Journal
  
  Volume: 印刷中
- NAID
  130005153582
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460292
[Journal Article] Atrial fibrillation-mediated up-regulation of miR-30d regulates myocardial electrical remodeling of G-protein-gated K+ channel, IK.Ach2016
- Author(s)
  Morishima M, Iwata E, Nakada C, Tsukamoto Y, Takanari H, Moriyama M, Miyamoto S, Ono K
- Journal Title
  
  Circulation Journal
  
  Volume: in press
- NAID
  130005153582
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08179
[Journal Article] Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K+ Channel, IK.ACh2016
- Author(s)
 Morishima M, Iwata E, Nakada C, Tsukamoto Y, Takanari H, Miyamoto S, Moriyama M, Ono K
- Journal Title
 
 Circ J
 
 Volume: 80 Issue: 6 Pages: 1346-1355
- DOI
 10.1253/circj.CJ-15-1276
- NAID
 130005153582
- ISSN
 1346-9843, 1347-4820
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16H05238, KAKENHI-PROJECT-15K08179, KAKENHI-PROJECT-15K08405, KAKENHI-PROJECT-16K08498
[Journal Article] Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil2015
- Author(s)
  Ma F, Takanari H, Masuda K, Morishima M, Ono K
- Journal Title
  
  Heart Vessels
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08179
[Journal Article] Hypomagnesemic down-regulation of L-type Ca2+ channel in cardiomyocyte as an arrhythmogenic substrate in rats2015
- Author(s)
  Shimaoka T, Wang Y, Morishima M, Miyamoto S, Ono K
- Journal Title
  
  Pathophysiology
  
  Volume: 22 Issue: 2 Pages: 87-93
- DOI
  10.1016/j.pathophys.2015.01.002
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460292
[Journal Article] Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil2015
- Author(s)
  Ma F, Takanari H, Masuda K, Morishima M, Ono K
- Journal Title
  
  Heart and Vessels
  
  Volume: 印刷中 Issue: 7 Pages: 1176-1184
- DOI
  10.1007/s00380-015-0762-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460292, KAKENHI-PROJECT-15K08179
[Journal Article] Sodium channel as a gate for molecular arrhythmology2011
- Author(s)
  K.Ono
- Journal Title
  
  J Arrhythmia
  
  Volume: 27 Pages: 91-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590934
[Journal Article] Sodium channel as a target for molecular arrhythmia2011
- Author(s)
  K. Ono
- Journal Title
  
  J Arrhythmia
  
  Volume: 27 Pages: 91-95
- Data Source
  KAKENHI-PROJECT-21590934
[Journal Article] β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model2010
- Author(s)
  A. Hattori, K. Mawatari, S. Tsuzuki, E. Yoshioka, S. Toda, M. Yoshida, S. Yasui, H. Furukawa, M. Morishima, K. Ono, T. Ohnishi, M. Nakano, N. Harada, A. Takahashi, Y. Nakaya
- Journal Title
  
  SPORTS. Obesity
  
  Volume: 18 Pages: 45-54
- Data Source
  KAKENHI-PROJECT-21590934
[Journal Article] Point mutations in domain II of the voltage-gated sodium channel gene in deltamethrin-resistant Aedes aegypti(Diptera : Culicidae)2010
- Author(s)
  R. Srisawat, N. Komalamisra, Y. Eshita, M. Zheng, K. Ono, T. Q. Itoh, A. Matsumoto, S. Petmitr, Y. Rongsriyam
- Journal Title
  
  Appl Entomol Zool
  
  Volume: 45 Pages: 275-282
- NAID
  130000248672
- Data Source
  KAKENHI-PROJECT-21590934
[Journal Article] Nonapeptide hormones oxytocin and vasopression distinctly regulate Ca_V1. 2 L-type Ca^<2+> channel expression in cardiomyocytes2010
- Author(s)
 M. Morishima, S. Tahara, Y. Wang, T. Kaku, K. Ono
- Journal Title
 
 J Arrhythmia
 
 Volume: 26 Pages: 111-118
- Data Source
 KAKENHI-PROJECT-21590934
[Journal Article] Intracellular Ca^<2+>-and PKC-dependent upregulation of T-type Ca^<2+> channels in LPC-stimulated cardiomyocytes2010
- Author(s)
 M. Zheng, Y. Wang, L. Kang, T. Shimaoka, F. Marni, K. Ono
- Journal Title
 
 J Mol Cell Cardiol
 
 Volume: 48 Pages: 131-139
- Data Source
 KAKENHI-PROJECT-21590934
[Journal Article] β-Adrenergic-AMPK Pathway Phosphorylates Acetyl-CoA Carboxylase in a High-epinephrine Rat Model, SPORTS2010
- Author(s)
  A.Hattori, K.Mawatari, S.Tsuzuki, E.Yoshioka, S.Toda, M.Yoshida, S.Yasui, H.Furukawa, M.Morishima, K.Ono, T.Ohnishi, M.Nakano, N.Harada, A.Takahashi, Y.Nakaya
- Journal Title
  
  Obesity
  
  Pages: 45-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590934
[Journal Article] Intracellular Ca2+- and PKC-dependent upregulation of T-type Ca2+ channels in LPC-stimulated cardiomyocytes2010
- Author(s)
  M.Zheng, Y.Wang, L.Kang, T.Shimaoka, F.Marni, K.Ono
- Journal Title
  
  J Mol Cell Cardiol
  
  Volume: 48 Pages: 131-139
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590934
[Journal Article] Nonapeptide hormones oxytocin and vasopression distinctly regulate CaV1.2 L-type Ca2+ channel expression in cardiomyocytes2010
- Author(s)
  M.Morishima, S.Tahara, Y.Wang, T.Kaku, K.Ono
- Journal Title
  
  J Arrhythmia
  
  Volume: 26 Pages: 111-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590934
[Journal Article] Point mutations in domain II of the voltage-gated sodium channel gene in deltamethrin-resistant Aedes aegypti (Diptera : Culicidae)2010
- Author(s)
  R.Srisawat, N.Komalamisra, Y.Eshita, M.Zheng, K.Ono, T.Q.Itoh, A.Matsumoto, S.Petmitr, Y.Rongsriyam
- Journal Title
  
  Appl Entomol Zool
  
  Volume: 45 Pages: 275-282
- NAID
  130000248672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590934
[Journal Article] Telmisartan, an angiotensin II type 1 receptor antagonist, attenuates T-type Ca^<2+> channel expression in neonatal rat cardiomyocytes2009
- Author(s)
 M. Morishima, Y Wang, Y. Akiyoshi, S. Miyamoto, K. Ono
- Journal Title
 
 Eur J Pharmacol
 
 Volume: 609 Pages: 105-112
- Data Source
 KAKENHI-PROJECT-21590934
[Journal Article] 17β-estradiol modulates expression of low-voltage-activated Ca_V3. 2 T-type Ca^<2+> channel via ERKs pathway in cardiomyocytes2009
- Author(s)
 F. Marni, Y. Wang, M. Morishima, T. Shimaoka, T. Uchino, M. Zheng, T. Kaku, K. Ono
- Journal Title
 
 Endocrinology
 
 Volume: 150 Pages: 879-888
- Data Source
 KAKENHI-PROJECT-21590934
[Journal Article] Rescue of Pulmonary Hypertension with an Oral Sulfonamide Antibiotic Sulfisoxazole by Endothelin Recepter Antagonistic Actions2008
- Author(s)
  Uchino T, Sanyal SN, Yamabe M, Kaku T, Takebayashi S, Shimaoka T, Shimada T, Noguchi T, Ono K
- Journal Title
  
  Hypertension Research 31(9)
  
  Pages: 1781-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590823
[Journal Article] 17β-estradiol modulates expression of low-voltage-activated CaV3.2 T-type calcium channel via ERKs pathway in cardiomyocytes2008
- Author(s)
  Marni F, Wang Y, Morishima M, Shimaoka T, Uchino T, Zheng M-Q, Kaku T, Ono K
- Journal Title
  
  Endocrinology 150(2)
  
  Pages: 879-888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590823
[Journal Article] Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca^<2+> channels in neonatal rat heart2007
- Author(s)
 Wang Y, Morishima M, Zheng M, Uchino T, Mannen K, Takahashi A, Nakaya Y, Komuro I, Ono K
- Journal Title
 
 J Mol Cell Cardiol 42
 
 Pages: 1045-1053
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-19590823
[Journal Article] Three different bradycardic agents, zatebradine, diltiazem and propranolol, distinctly modify heart rate variability and QT-interval variability2007
- Author(s)
  Yamabe M, Sanyal SN, Miyamoto S, Hadama T, Isomoto S, Ono K
- Journal Title
  
  Pharmacology 80
  
  Pages: 293-303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590823
[Journal Article] Lysophosphatidylcholine Augments Cav3.2 but Not Cav3.1 T-Type Ca2+ Channel Current Expressed in HEK-293 Cells.2006
- Author(s)
  Zheng M, Uchino T, Kaku T, Kang L, Wang Y, Takebayashi S, Ono K
- Journal Title
  
  Pharmacology 76(4)
  
  Pages: 192-200
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Effects of Antiarrhythmic Drugs on Apoptotic Pathway in H9c2 Cardiac Cells.2006
- Author(s)
  Isomoto S, Kawakami A, Arakaki T, Yamashita S, Yano K, Ono K
- Journal Title
  
  J Pharmacol Sci 101
  
  Pages: 318-324
- NAID
  10018236532
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Actions of Mibefradil, Efonidipine and Nifedipine Block of Recombinant T-and L-Type Ca2+ Channels with Distinct Inhibitory Mechanisms.2006
- Author(s)
  Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K
- Journal Title
  
  Pharmacology 78
  
  Pages: 11-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Remodeling Excitation-Contraction Coupling of Hypertrophied Ventricular Myocytes is Dependent on T-type Calcium Channels Expression.2006
- Author(s)
  Takebayashi T, Li Y, Kaku T, Inagaki S, Hashimoto Y, Kimura K, Miyamoto S, Hadama T, Ono K
- Journal Title
  
  BBRC 345(2)
  
  Pages: 766-773
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Distinction Between Steady-State Inactivation and Voltage-Dependent Facilitation in L-type Ca2+ Channel α 1c and α 1c/β Subunits.2006
- Author(s)
  Lee TS, Ono K, Miyamoto S, Hadama T, Arita M
- Journal Title
  
  J UOEH 28(3)
  
  Pages: 277-286
- NAID
  110004781876
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Short-and Long-Term Amiodarone Treatments Regulate Cav3.2 Low-Voltage-Activated T-type Ca2+ Channel through Distinct Mechanisms.2006
- Author(s)
  Yamashita N, Kaku T, Uchino T, Isomoto S, Yoshimatsu H, Ono K
- Journal Title
  
  Mol Pharmacol 69
  
  Pages: 1684-1691
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] T型Ca^<2+>チャネルの機能と病態2005
- Author(s)
 小野克重
- Journal Title
 
 Jpn J Electrocardiology 25(6)
 
 Pages: 541-546
- NAID
 10016912187
- Data Source
 KAKENHI-PROJECT-17590755
[Journal Article] Function and pathophysiology of the T-type Ca2+ channel.2005
- Author(s)
  Ono K
- Journal Title
  
  Jpn J Electrocardiology 25(6)
  
  Pages: 541-546
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] T型Ca^<2+>チャネルの機能と病態2005
- Author(s)
 小野克重
- Journal Title
 
 Jpn J Electrocardiology 25 (6)
 
 Pages: 541-546
- NAID
 10016912187
- Description
 「研究成果報告書概要(和文)」より
- Data Source
 KAKENHI-PROJECT-17590755
[Journal Article] TCCおよびT-CCBに関する基礎研究2005
- Author(s)
  小野克重
- Journal Title
  
  第2回TCCフォーラムハイライト集
  
  Pages: 4-4
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Differentiation of P19CL6 cells into cardiomyocytes was dependent on GATA4 via activation of p38-MAPK.2005
- Author(s)
  Zheng M, Uchino T, Takebayashi S, Kaku T, Wang Y, Ono K
- Journal Title
  
  Jpn J Electrocardiology 25(6)
  
  Pages: 495-501
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Voltage-dependent and frequency-independent inhibition of recombinant Cav3.2 T-type Ca2+ channel by Bepridil.2005
- Author(s)
  Uchino T, Lee TS, Kaku T, Yamashita N, Noguchi T, Ono K
- Journal Title
  
  Pharmacology 74
  
  Pages: 174-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590755
[Journal Article] Pathophysiology in Na channels "Molecular function and kinetics in Na^+ channelopathy"2003
- Author(s)
  Ono K
- Journal Title
  
  HEART 35(6)
  
  Pages: 449-458
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590759
[Journal Article] The gating and conductance properties of Ca_v3.2 low-voltage-activated T-type calcium channels2003
- Author(s)
  Kaku T, Lee TA, Arita M, Hamada T, Ono K
- Journal Title
  
  Japanese Journal of Physiology 53
  
  Pages: 165-172
- NAID
  10011711926
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590759
[Journal Article] The gating and conductance properties of Cav3.2 low-voltage-activated T-type calcium channels.2003
- Author(s)
  Kaku T, Lee TA, Arita M, Hadama T, Ono K
- Journal Title
  
  Japanese Journal of Physiology 53
  
  Pages: 165-172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590759
[Journal Article] The gating and conductance properties of Ca_V3.2 low-voltage-activated T-type calcium channels2003
- Author(s)
  Kaku T, Lee TA, Arita M, Hadama T, Ono K
- Journal Title
  
  Japanese Journal of Physiology 53
  
  Pages: 165-172
- NAID
  10011711926
- Data Source
  KAKENHI-PROJECT-15590759
[Journal Article] Na^+チャネルの病態生理学-分子構造に依存する開閉機構と遺伝性疾患との関わり-2003
- Author(s)
  小野克重
- Journal Title
  
  心臓 35(6)
  
  Pages: 449-458
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590759
[Journal Article] Na^+チャネルの病態生理学 -分子構造に依存する開閉機構と遺伝性疾患との関わり-2003
- Author(s)
  小野克重
- Journal Title
  
  心臓 35(6)
  
  Pages: 449-458
- Data Source
  KAKENHI-PROJECT-15590759
[Presentation] 『Mechanism for binge-alcohol-drinking-induced atrial fibrillation』2021
- Author(s)
  小野克重
- Organizer
  第8回国際心脳血管フォーラム（8th International Cardiocerebrovascular From）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07277
[Presentation] ヒト心房細動心筋において過剰発現するmiR-30dの機能解析2016
- Author(s)
  岩田絵理子、森島真幸、高成広起、宮本伸二、小野克重
- Organizer
  第26回日本病態生理学会大会
- Place of Presentation
  金沢医科大学(石川県河北郡内灘町)
- Year and Date
  2016-08-05
- Data Source
  KAKENHI-PROJECT-15K08179
[Presentation] A novel pathway for up-regulation of microRNA expression in cardiomyocytes exposed to angiotensin Ⅱ2016
- Author(s)
  Yabusaki M, Morishima M, Takanari H, Ono K
- Organizer
  第93回日本生理学会大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-15K08179
[Presentation] BDNF/TrkB signaling modulates T-type Ca2+ channel expression in cardiomyocytes exposed2015
- Author(s)
  Morishima M, Fujita T, Osagawa S, Ono K
- Organizer
  第30回日本不整脈学会学術大会・第32回日本心電学会学術集会
- Place of Presentation
  京都国際会議場（京都府京都市）
- Year and Date
  2015-07-29
- Data Source
  KAKENHI-PROJECT-15K08179
[Presentation] 心房細動の発症とイオンチャネルリモデリング2011
- Author(s)
  小野克重
- Organizer
  秋田ハートクラブ発表会
- Place of Presentation
  秋田
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] 心房細動の発症基盤と治療薬の作用機序2011
- Author(s)
  小野克重
- Organizer
  静岡ハートフォーラム
- Place of Presentation
  静岡
- Year and Date
  2011-06-16
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] Protein kinase C as an upstream signal to activate Csx/Nkx2. 5 and nFAT transcription to accelerate Cav3. 2 Ca2+channel expression2010
- Author(s)
  王岩, 森島真幸、嶋岡徹, 小野克重
- Organizer
  第74回日本循環器学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] エタノールは肺静脈細胞のT型Ca2+チャネルの発現を増加させる2010
- Author(s)
  王岩, 森島真幸, 賀来俊彦, 小野克重
- Organizer
  第20回日本病態生理学会大会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] Effects of physical exercise on cardiac Ca2+channel expression in SPORTS rat, a novel rat-strain feautured by high levels of voluntary wheel-running activity2010
- Author(s)
  Morishima M, Wang Y, Akiyoshi Y, Ono K
- Organizer
  第20回ISHR世界大会2010京都
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] Transcription factor Csx/Nkx2. 5 and nFAT regulate expression of Cav3. 2 T-type Ca2+channel via protein kinase C actions2010
- Author(s)
  Ono K, Morishima M, Wang Y
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] アンジオテンシン受容体を介した心筋T型カルシウムチャネルの発現抑制2010
- Author(s)
  森島真幸, 王岩, 秋吉裕子, 小野克重
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] Transcription factor Csx/Nkx2.5 and nFAT regulate expression of Cav3.2 T-type Ca2+ channel via protein kinase C actions2010
- Author(s)
  Ono K
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Year and Date
  2010-03-17
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] Oxytocinによる心筋L型Ca2+チャネルの転写制御機2009
- Author(s)
  森島真幸, 田原慎太郎, 王岩, 秋吉裕子, 賀来俊彦, 小野克重
- Organizer
  第19回日本病態生理学会大会
- Place of Presentation
  所沢
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] PKC活性に依存する新生ラット心筋細胞T型Ca2+チャネルのSubtype変換2009
- Author(s)
  王岩, 森島真幸, 賀来俊彦, 小野克重
- Organizer
  第60回西日本生理学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] PKCは新生ラッと心筋細胞のT型Ca2+チャネルのSubtype変換を制御する2009
- Author(s)
  王岩, 森島真幸, 賀来俊彦, 嶋岡徹, 康林, 小野克重
- Organizer
  第19回日本病態生理学会大会
- Place of Presentation
  所沢
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] エタノールは肺静脈心筋細胞のT型Ca2+チャネルの発現を増加させる2009
- Author(s)
  王岩, 森島真幸, 康林, 賀来俊彦, 小野克重
- Organizer
  第26回日本心電学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] Oxytocinは幼若ラット心筋細胞において転写因子CREBを介してL型Ca2+チャネル(CaV1. 2)発現を抑制する2009
- Author(s)
  森島真幸, 田原慎太郎, 秋吉裕子、王岩, 賀来俊彦, 小野克重
- Organizer
  第26回日本心電学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] シンポジウム2009
- Author(s)
  小野克重
- Organizer
  第26回日本心電学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] Nonapeptide hormone oxytocin regulates Cav1. 2 L-type calcium channel expression in cardiomyocytes2009
- Author(s)
  Morishima M, Wang Y, Kaku T, Ono K
- Organizer
  第26回ISHR日本部会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21590934
[Presentation] Protein kinase C as a key modulator to switch isoforms from Cav3. 2 to Cav3. 1 of the T-type Ca2+channel in neonatal rat crdiomyocytes
- Author(s)
  Wang Y, Morishima M, Kang L, Kaku T, Ono K
- Organizer
  APHRS 2009(2nd Asia Pacific Heart Rhythm Society Scientific Sessions 5th Asia Pacific Atrial Fibrillation Symposium)
- Place of Presentation
  Beijing International Convention Center, China
- Data Source
  KAKENHI-PROJECT-21590934

1. LEE Tae-seong (10336266)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. MORISHIMA Masaki (40437934)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. ARITA Makoto (60037364)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ZENG Ming-qi (90433052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IWATA Eriko (70457604)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAKU Toshihiko (40372792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
7. 穴井博文 (20291544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 葉玉哲生 (00145377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 平岡善憲 (90253799)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ONO Katsushige 小野 克重

Research Projects

Research Products

Co-Researchers

Mechanisms for extracellular electrolyte-dependent regulation of ion channel expressionPrincipal Investigator

Principal Investigator

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Review Section

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Development of new diagnostic methods for atrial fibrillation based on miR-30d as a baiomarkerPrincipal Investigator

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MicroRNA overexpression to establish a new arrhythmia model for studying its molecular mechanism.

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Regulation of microRNAs responsible for ion channel remodeling in atrial fibrillationPrincipal Investigator

Principal Investigator

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MicroRNAs Analysis for Investigation of the Causes in Human Atrium Electrical Remodeling

Principal Investigator

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Oncogene TRE regulates voltage-gated Na^+ channel remodelingPrincipal Investigator

Principal Investigator

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Research Institution

Investigations on the T-type Ca^<2+> channel as a trigger for cellular Ca^<2+>-overload and clinical insight to regulate cellular apoptosisPrincipal Investigator

Principal Investigator

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Research Institution

Research on the development of biopacemaker by use of plnipotent P19CL6 cells.Principal Investigator

Principal Investigator

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Research Institution

Electrophysiological determination of P19CL6-derived cardiomyocytes and their modification by the transcription factor Csx/Nkx2-5Principal Investigator

Principal Investigator

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Research Institution

移植心筋へのイオンチャネル遺伝子導入による心臓電気興奮性の制御

Principal Investigator

Project Period (FY)

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Functional Expression of L-Type Cardiac Calcium Channels in Mammalian Cell in in vivo and in vitro by Use of Adenovirus.Principal Investigator

Principal Investigator

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Research Institution

MOLECULAR FUNCTION OF CHIMERIC Ca-Na IONIC CHANNELSPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

移植心の体液性機能調節の再成立に関する電気生理学的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

ONO Katsushige 小野克重

[Book] 別冊・医学のあゆみイオンチャネル最前線update2005