TAKEDA Michio 武田理夫

Researcher Number	40255401
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2001 – 2003: Kyorin University, School of Medicine, Associate Professor, 医学部, 助教授 1995 – 2000: 杏林大学, 医学部, 講師 1993 – 1995: 杏林大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Kidney internal medicine / Kidney internal medicine / General pharmacology Except Principal Investigator 応用薬理学・医療系薬学 / General pharmacology / Kidney internal medicine
Keywords	Principal Investigator 近位尿細管 / Drug transport / 薬物輸送 / Proximal tubule / 有機アニオントランスポータ / 安定発現細胞 / Cell line / Cell cycle / Caspase / Anti-arrhythmia … More / Diuretics / Organic cation transport / Kidney / Organic anion transport / 抗不整脈薬 / 利尿薬 / 有機カチオン輸送 / 腎臓 / 有機アニオン輸送 / stable cell line / Clinical implication / Tubular secretion / Human organic cation transporter / Human organic anion transporter / 腎排泄 / 有機カチオントランスポータ / ヒト有機カキオントランスポータ / 臨床的意義 / 尿細管分泌 / ヒト有機カチオントランスポータ / ヒト有機アニオントランスポータ / Ochratoxin A / Nephrotoxicity / Cephaloridine / Organic anion transporter / 薬物性腎障害 / セファロスポリン系抗生物質 / セファロリジン / 有機アニオントランスポーター / Free radical / Oncogene / Apoptosis / Cisplatin / CrmA / CPP32 / ICE / ICE family protease / SV40 / G_2 arrest / 細胞周期制御 / 活性酸素 / c-fos / 腎由来細胞株 / アポトーシス / シスプラチン / アフリカツメガエル卵母細胞 / 結合実験 / polymerase chain reaction / バソップレシン受容体 … More Except Principal Investigator kidney / トランスポーター / organic anion transporter / pharmacokinetics / organic anion / エストロン硫酸 / パラアミノ馬尿酸 / 有機アニオン / rBAT / BAT1 / knockout mouse / organic anion transporter3 / organic anion transporter2 / organic anion transporter1 / brain / liver / drug transporter / transporter / hOAT1 / 薬物輸送 / オクラトキシンA / proximal tubules / ATP / intracellular calcium / purinoceptor / シスプラチン / 近位尿細管中間部 / 有機アニオントランスポーター / ジカルボン酸トランスポーター / ジカルボン酸 / アンモニア産生 / SV40-T抗原 / トランスジェニックマウス / 近位尿細管 / 単一ネフロン / environmental factor / genetic factor / renal stones / Sodium-bicarbonate cotransporter / Cystinuria / Proximal tubular acidosis / rBATl / BATl / 近位尿再管性アシドーシス / ナトリウム / 環境因子 / 遺伝因子 / 尿路結石 / 重炭酸イオン共輸送体 / Na+ / シスチン尿症 / 近位尿細管性アシドーシス / Sertoli cell / Epididymis / SNP / Uric acid / Idopathic renal hypouricemia / Carnitine / Cation transporter / Anion transporter / デヒドロエピアンドロステロン硫酸 / エクソン / イントロン / 一塩基変異遺伝子多型 / 突発性腎性低尿酸血症 / 胎盤 / セルトリ細胞 / 精巣上体 / 一塩基変異遺伝子 / 尿酸 / 特発性腎性低尿酸血症 / カルニチン / カチオントランスポーター / アニオントランスポーター / L-Dopa / Triiodethyronie / Aromatic amino acid / Heterocllimer / Associating protein / LAT family / Organic anion transporter / Drug transporter / システイン抱合体 / サリチル酸 / OATファミリー / 有機陰イオントランスポーター(OAT) / メチル水銀システイン抱合体 / 血液脳関門 / L-ドーパ / トリヨードサイロニン / 芳香族アミノ酸 / ヘテロダイマー / 補助因子 / LATファミリー / 有機陰イオントランスポーター / 薬物トランスポーター / gene targeting / gene targetting / molecular cloning / blood-brain barrier / drug transport / organic cation / cloning / placenta / 分子クローニング / 腎 / 血液・組織関門 / 薬物動態 / 有機カチオン / culture cell / 腎臓 / 培養細胞 / 有機酸 / multispecific substrate recognition / carnitine transporter / organic cation transporter / ochratoxin A / estron sulfate / para-amino hippurate / 多選択性基質認識 / カルニチントランスポーター / 有機カチオントランスポーター / mesangial cells / nephron segments / desensitization / 細胞内カルシウム / 尿細管 / P_<2U> / P_<2Y> / calcium / nephron / phosphorylation / protein kinase C / purinoreceptor / mesangial cell / nephron segment / membrane transport / excitotoxicity / neurotoxicity / neuro transmission / Central nervous system / Transporter / Glutamate / 膜輸送 / 興奮毒性 / 神経毒性 / 神経伝達 / 中枢神経系 / グルタミン酸 / cisplatin / ATP receptor / nephron segment-specific metabolism / nephron segment-specific enzyme / immortalized cell lines / single nephron / SV40 large T antigen gene / transgenic mouse / サイクリックAMP / アルカリフォスファターゼ / サイクリツクAMP / 集合尿細管 / 温度感受性因子 / トランスジエニックマウス / ATP受容体 / ネフロン分節特異代謝 / ネフロン分節特異酵素 / 不死化細胞株 / SV40-T抗原遺伝子 / デキサメサゾン / 陰イオン有機酸輸送 / アポトーシス / 髄質外層集合管 / 近位尿細管終末部 / 不死化細胞 / 腎内蓄積 / 腎内輸送 / β-ラクタム抗生物質 / プロスタグランジン / 近位尿細管直部 / アルギニンバゾプレシン / 発現クローニング / V_2受容体 / 細胞内遊離カルシウム / アルギニンバソプレシン Less

Study of drug transport mechanism by renal organicion transporters and their clinical significancePrincipal Investigator
- Principal Investigator
  
  HOSOYAMADA Makoto, 武田理夫
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University
Genetic Abnormality of Renal Proximal Tubule-Specific Transporters as Causes of Sudden Death Syndrome in South-Eastern Asia
- Principal Investigator
  
  ENDOU Hitoshi
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyorin University
Clinical implication of organic anion transporters in the proximal tubulePrincipal Investigator
- Principal Investigator
  
  TAKEDA Michio
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University
Identification of transporter genes regulating systemic kinetics of drugs and foreign compounds and their genetic polymorphism
- Principal Investigator
  
  ENDOU Hitoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyorin University
Cloning of transporters for anionic drugs and the application to pharmacokinetic analysis
- Principal Investigator
  
  KANAI Yoshikatsu, 関根孝司
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University
FUNCTIONAL ANALYSIS OF THE ANIONIC DRUG TRANSPORTERS USING KNOCKOUT MICE
- Principal Investigator
  
  INATOMI Jun, 車碩鎬
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University
The elucidation of cephaloridine-induced nephrotoxicity in cell lines stably expressing organic anion transportersPrincipal Investigator
- Principal Investigator
  
  TAKEDA Michio
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University
Molecular mechanisms of drug transport across cell membrane
- Principal Investigator
  
  ENDOU Hitoshi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyorin University
Development of artificial kidney hybridized with human organic anion transporter expressed cells
- Principal Investigator
  
  HOSOYAMDA Makoto
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University
Molecular cloning and functional expression of kidney-specific organic anionic drug transporters
- Principal Investigator
  
  ENDOU Hitoshi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University School of Medicine
Elucidation of the intracellular mechanisms of cisplatin-induced apoptosis in renal cell linePrincipal Investigator
- Principal Investigator
  
  TAKEDA Michio
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kyorin University School of Medicine
The study toward the development of specific agonist and antagonist for the purinergic receptors in the kidney
- Principal Investigator
  
  SEKINE Takashi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyorin University
腎毒性予測法の開発
- Principal Investigator
  
  遠藤仁
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Kyorin University
Roles of glutamate transporters in the nervous system
- Principal Investigator
  
  KANAI Yoshikatsu
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyorin University
近位尿細管に存在する新しいバソップレシン受容体の遺伝子クローニングPrincipal Investigator
- Principal Investigator
  
  武田理夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University
新しいvasopressin受容体(Vp)の構造と機能に関する分子薬理学的研究
- Principal Investigator
  
  ENDOU Hitoshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyorin University
  The University of Tokyo
Establishment of immotalized cell lines from transgenic mouse nephron segments
- Principal Investigator
  
  ENDOU Hitoshi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Department of Pharmacology and Toxicology, Kyorin University School of Medicine
  The University of Tokyo

All 2005 2004 2003 2002 2001

All Journal Article Book

[Book] Annual Review腎臓20012001
- Author(s)
  武田理夫
- Total Pages
  4
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules.2005
- Author(s)
  Anzai N, Jutabha P, Enomoto A, Yokoyama H, Nonoguchi H, Hirata T, Shiraya K, He X, Cha SH, Takeda M, Miyazaki H, Sakata T, Tomita K, Igarashi T, Kanai Y, Endou H.
- Journal Title
  
  J Pharmacol Exp Ther. 315(2)
  
  Pages: 534-544
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Interactions of human organic anion transporters with diuretics.2004
- Author(s)
  Hsannejad, H., M.Takeda, et al.
- Journal Title
  
  J Pharmacol Exp Ther 308(3)
  
  Pages: 1021-1029
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590858
[Journal Article] Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.2004
- Author(s)
  Khamdang, S., M.Takeda, et al.
- Journal Title
  
  J Pharmacol Sci 94(2)
  
  Pages: 197-202
- NAID
  130000073873
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590858
[Journal Article] Interactions of human- and rat -organic anion transporters with pravastatin and cimetidine.2004
- Author(s)
  Khamdang, S., M.Takeda, et al.
- Journal Title
  
  J Pharmacol Sci 94-2
  
  Pages: 197-202
- NAID
  130000073873
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590858
[Journal Article] Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs.2004
- Author(s)
  Hasannejad, H., M.Takeda, et al.
- Journal Title
  
  Eur J Pharmacol 499(1-2)
  
  Pages: 45-51
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590858
[Journal Article] Interactions of human organic anion transporters with diuretics.2004
- Author(s)
  Hasanne jad H, Takeda M, Taki K, Shin HJ, Babu E, Jutabha P, Khamdang S, Aleboyeh M, Onozato ML, Tojo A, Enomoto A, Anzai N, Narikawa S, Huang XL, Niwa T, Endou H.
- Journal Title
  
  J Pharmacol Exp Ther. 308(3)
  
  Pages: 1021-1029
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Evidence for a role of human organic anion transporters in the muscular side effects of HMG-GoA reductase inhibitors.2004
- Author(s)
  Takeda M, Norshio R, Onozato ML, Tojo A, Hasannejad H, Hang XL, Narikawa S, Endou H.
- Journal Title
  
  Eur.J.Pharmacol. 483
  
  Pages: 133-138
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Human organic cation transporter 3 mediates the transport of antiarrhythmic drugs.2004
- Author(s)
  Hassannejad H, Takeda M, Narikawa S, Huang XL, Enomoto A, Taki K, Niwa T, Shin HJ, Onozato ML, Tojo A, Endou H
- Journal Title
  
  Euro J Pharmacol. 499
  
  Pages: 45-51
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Interactions of human organic anion transporters with diuretics.2004
- Author(s)
  Hasannejad H, Takeda M, Taki K, Jung SH, Babu F, Jutabha P, Khamdang S, Aleboyen M, Onodera ML, Tojo A, Enomoto A, Anzai N, Narikawa S, Huang XL, Niwa T, Endou H.
- Journal Title
  
  J Pharmacol Exp Ther. 308(3)
  
  Pages: 1021-1029
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Interactions of human organic anion transporters with diuretics.2004
- Author(s)
  Hasannejad, H., M.Takeda, et al.
- Journal Title
  
  J Pharmacol Exp Ther 308(3)
  
  Pages: 1021-1029
- Data Source
  KAKENHI-PROJECT-15590858
[Journal Article] Human organic anion transporter 4 is a renal apical organic anion / dicarboxylate exchanger in the proximal tubules.2004
- Author(s)
  Ekaratanawong S, Anzai N, Jutabha P, Miyazaki H, Moshiro R, Takeda M, Kanai, Endou, H.
- Journal Title
  
  Pharmacol Sci 94
  
  Pages: 297-304
- NAID
  130000073849
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Interactions of human organic anion transporters with diuretics.2004
- Author(s)
  Hasannejad, H., M.Takeda, et al.
- Journal Title
  
  J Pharmacol Exp Ther 308-3
  
  Pages: 1021-1029
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590858
[Journal Article] Interactions of human- and rat-organic anion transporters with pravastatih and cimetidine.2004
- Author(s)
  Kahmdan S, Takeda M, Shimoda M, Noshiro Ri, Narikawa S, Huang XL, Enomoto A, Piyachaturawat P, Hitoshi E
- Journal Title
  
  Pharmacol Sci. 94
  
  Pages: 197-202
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Interactions of human organic anion as well as cation transporters with indoxyl sulfate.2003
- Author(s)
  Enomoto A, Takeda M, Taki K, Takayama F, Noshiro R, Niwa T, Endou H.
- Journal Title
  
  Eur J Pharmacol. 466(1-2)
  
  Pages: 13-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Urate transport via human PAH transporter hOAT1 and its gene structure.2003
- Author(s)
  Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H.
- Journal Title
  
  Kidney Int. 63(1)
  
  Pages: 143-155
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics.2003
- Author(s)
  Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H.
- Journal Title
  
  Eur J Pharmacol. 465(1-2)
  
  Pages: 1-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Molecular identification of a renal urate-anion exchanger that regulates blood urate levels.2002
- Author(s)
  Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H.
- Journal Title
  
  Nature 417
  
  Pages: 447-452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Characterizaion of organic anion transport inhibitors using cells stably expressing human organic anion tansporters2001
- Author(s)
  Takeda M
- Journal Title
  
  Eur J Pharmacol 419
  
  Pages: 113-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13376004
[Journal Article] Characterizaion of organic anion transport inhibitors using cells stably expressing human organic anion tansporters.2001
- Author(s)
  Takeda M, Narikawa S, Hosoyamada M, Cha SH, Sekine T, Endou H.
- Journal Title
  
  Eur J Pharmacol. 419
  
  Pages: 113-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13376004

1. ENDOU Hitoshi (20101115)

# of Collaborated Projects: 15 results

# of Collaborated Products: 11 results
2. HOSOYAMADA Makoto (00291659)

# of Collaborated Projects: 11 results

# of Collaborated Products: 3 results
3. KANAI Yoshikatsu (60204533)

# of Collaborated Projects: 9 results

# of Collaborated Products: 3 results
4. SEKINE Takashi (50255402)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
5. CHA Seok ho (50276200)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
6. INATOMI Jun (00311960)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
7. KIM Do Kyung (40327474)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
8. ANZAI Naohiko (70276054)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
9. MIZUNO Akiko (60255403)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. TATE Naoko (00201955)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OBINATA Masuo (10099971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. IRIBE Yuji (20348618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HIRATA Taku (60372918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 河原克雅 (70134525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中尾彰秀 (10159056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NUSSBERGER Stephan

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HEDIGER Matt

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HEDIGEL Matthias a

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKEDA Michio 武田 理夫

Research Projects

Research Products

Co-Researchers

Study of drug transport mechanism by renal organicion transporters and their clinical significancePrincipal Investigator

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Clinical implication of organic anion transporters in the proximal tubulePrincipal Investigator

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The elucidation of cephaloridine-induced nephrotoxicity in cell lines stably expressing organic anion transportersPrincipal Investigator

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Elucidation of the intracellular mechanisms of cisplatin-induced apoptosis in renal cell linePrincipal Investigator

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近位尿細管に存在する新しいバソップレシン受容体の遺伝子クローニングPrincipal Investigator

Principal Investigator

Project Period (FY)

TAKEDA Michio 武田理夫