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Kobayashi Toshiyuki  小林 敏之

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KOBAYASHI Toshiyuki  小林 敏之

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Researcher Number 40260070
Other IDs
Affiliation (Current) 2025: 公益財団法人環境科学技術研究所, 生物影響研究部, 研究部長
2025: 順天堂大学, 大学院医学研究科, 客員准教授
Affiliation (based on the past Project Information) *help 2023: 公益財団法人環境科学技術研究所, 生物影響研究部, 研究部長
2021 – 2023: 順天堂大学, 大学院医学研究科, 客員准教授
2022: 公益財団法人環境科学技術研究所, 生物影響研究部, 主任研究員
2014 – 2020: 順天堂大学, 医学(系)研究科(研究院), 准教授
2016: 順天堂大学, 大学院医学研究科・分子病理病態学, 准教授 … More
2012: 順天堂大学, 医学(系)研究科(研究院), 准教授
2012: 順天堂大学, 医学部, 准教授
2009 – 2011: Juntendo University, 大学院・医学研究科, 准教授
2010: 順天堂大学, 医学研究科, 准教授
2009: 医学部, 准教授
2007 – 2009: 順天堂大学, 医学部, 准教授
2008: Juntendo University, 医学研究科, 准教授
2007: JUNTENDO UNIVERSITY, GRADUATE SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR
2004 – 2006: 順天堂大学, 医学部, 講師
2004: Department of Pathology, Juntendo University School of Medicine, Assistant Professor, 講師
2001 – 2003: Cancer Institute, Deprtment of Experimental Pathology, Associate, 癌研究所・実験病理部, 研究員
2001: 財団法人 癌研究会, 癌研究所・実験病理部, 研究員
2000: Cancer Institute, Dept.of Experimental Pathology, Research Associate, 癌研究所・実験病理部, 研究員
1998 – 1999: Cancer Institute, Dept.of Experimental Pathology, Associate, 癌研究所・実験病理部, 研究員
1998: 癌研究会, 癌研究所・実験病理部, 研究員
1997: Cancer Institute, Dept.of Experimental Pathology, Associate, 癌研究所・実験病理部, 研究員
1993 – 1997: 財団法人癌研究會, 癌研究所・実験病理部, 研究員
1995: Cancer Institute, Department of Experimental Pathology, Associate, 実験病理部, 研究員 Less
Review Section/Research Field
Principal Investigator
Laboratory animal science / Pathological medical chemistry / Experimental pathology / Biological Sciences / Experimental pathology
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Laboratory animal science / Biological Sciences / Tumor diagnostics / Pediatrics / Experimental pathology / Laboratory animal science
Keywords
Principal Investigator
Tsc2 / Tsc2遺伝子 / 結節性硬化症 / 動物モデル / Bhd / Ekerラット / モデル動物 / mTORC1 / AMPK / mTOR … More / 腎癌 / FnipL / ATP / Nihonラット / mesothelin / Erc / tuberin / Animal model / knockout mouse / Hamartin / 腎腫瘍 / ノックアウトマウス / Tsc1遺伝子 / Tsc2 gene / Eker rat / 腫瘍 / ES細胞 / 家族性腫瘍 / トランスジェニックマウス / 遺伝性疾患 / Bcat1遺伝子 / Bcat1 / エピゲノム修飾 / Tsc1/2 / アミノ酸代謝 / 腫瘍細胞 / 分岐鎖アミノ酸 / 代謝 / エピゲノム / 遺伝性難病 / Fnip 1 / BHDsyndrome / リン酸化 / Fnip1 / Bhd症候群 / Fnipl / BHD症候群 / Amino acid / Nihon rat / Hereditary renal cancer / 糖 / アミノ酸 / 遺伝性腎がん / S6 kinase / tuberous sclerosis / renal tumor / transgenic Eker rat / S6キナーゼ / トランスジェニックEkerラット / Renal tumor / Tuberous sclerosis / Tsc1 gene / 胎生致死 / 肝血管腫 / Transgenic mouse / Adenovirus / Cardiomyocyte / loxP sequence / Cre recombinase / Conditional gene targeting / プルキニエ細胞 / コンディショナル・ジーンターゲッティング / Cre組換え酵素 / 心筋細胞 / loxP配列 / アデノウイルス / コンデイショナル・ジーンターゲッテイング / Transgenic rat / Embryonic lethality / Renal cancer / Hereditary tumoar / 遺伝子導入ラット / 胎生期致死 / 遺伝性腫瘍 / 胚性幹細胞 / ラパマイシン / 細胞分化 / Birt-Hogg-Dube症候群 / folliculin / 細胞周期 / BHD / シグナル伝達 / サイクリンD1 / AMP依存性キナーゼ / mTORキナーゼ / TSC2遺伝子 / BHD遺伝子 / 遺伝性腎癌 / hamartin / Tsc1 / RAD51 / 遺伝子修復 / 遺伝子組換え / 肝発癌 … More
Except Principal Investigator
TSC2遺伝子 / 疾患モデル / 癌抑制遺伝子 / 遺伝性癌 / Eker rat / Tumor suppressor gene / Tsc2遺伝子 / 多段階発がん / ヒト結節性硬化症 / Animal model / 脂肪酸合成酵素 / ペルオキシソーム / 消化器癌 / 大腸癌 / 胃癌 / 極長鎖脂肪酸 / Erc / Erc遺伝子 / mTOR / Nihon rat / Niban gene / Tsc 2 gene / Tsc 1 gene / TSC1遺伝子 / Tsc2 gene / 結節性硬化症 / Tuberous sclerosis / TSC2 gene / 遺伝性腎癌 / ノックアウトマウス / GPIアンカー蛋白 / ERC遺伝子 / Bhd遺伝子 / TSC遺伝子 / Niban遺伝子 / 遺伝性がん / 腎発癌 / 脂肪酸伸長酵素 / 脂肪酸合成蛋白 / αシヌクレイン / 虫垂炎 / ASシード / 慢性虫垂炎 / 虫垂切除 / 脂肪代謝 / 虫垂 / αシニクレイン / パーキンソン病 / 腫瘍DNAパネル / HypoMethylation / HyperMethylation / 超高感度定量 / 高感度定量 / 融解曲線解析 / リアルタイムPCR / メチル化DNA / Mozaicism / Liquid biopsy / Hypomethylation / Hypermethylation / DNA メチル化 / SEPT9 / BRCA1 / MLH1 / 超高感度定量解析 / 高解像度融解曲線解析 / がん / リキッドバイオプシー / 大腸がん / 定量的超高感度解析 / DNAメチル化 / 癌治療、予防 / ガスダミンD / AOM/DSS / 副腎白質ジストロフィー / 自閉症スペクトラム障害 / mTOR / 行動薬理学 / モデルマウス / 自閉スペクトラム症 / Carcinogenesis / knockout mouse / GPI anchor protein / Mesothelin gene / 発がん / Mesothelin遺伝子 / hereditary cancer / Ere gene / Bhd gene / Tsc1遺伝子 / 腎発がん / 起始遺伝子 / Rapamycin / Erc gene / Anima model / TSCI gene / Human tuberous sclerosis / Multistage carcinogenesis / Hereditary renal carcinoma / Canier Genetics / wilms腫瘍 / 胸腺腫 / 前立腺癌 / 肝癌 / 腎癌 / ラット発癌 / BUF / ラットゲノム / Mnaラット / BUM / LECラット / 癌感受性遺伝子 / がん抑制遺伝子 / 遺伝性腎がん / Ekerラット / Renalcarcinogenesis / Hereditary cancer / シグナル伝達 / Erc/mesothelin / 遺伝子発現 / 分子標的治療 / 癌化遺伝子 / Positinal cloning / gene mapping / 2 hit / Cancer syndrome / 遺伝性腎癌ラット Less
  • Research Projects

    (25 results)
  • Research Products

    (85 results)
  • Co-Researchers

    (35 People)
  •  極長鎖脂肪酸をターゲットとした新規抗癌治療戦略

    • Principal Investigator
      折田 創
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Juntendo University
  •  Mechanism elucidation for influences of the Parkinson disease after appendectomy

    • Principal Investigator
      Fukunaga Tetsu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Juntendo University
  •  Anticancer treatment targeted fot VLCFA

    • Principal Investigator
      Orita Hajime
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Juntendo University
  •  Metabolic changes and epigenetic abnormalities caused by tuberous sclerosis compex (TSC) gene mutationPrincipal Investigator

    • Principal Investigator
      Kobayashi Toshiyuki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Juntendo University
  •  Devolopment for highly sensitive and quantitative methods with a facile, fast and low-cost protocol.

    • Principal Investigator
      NOMURA Sachio
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor diagnostics
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Development of novel therapeutic drugs targeting the mechanism of differentiation abnormality for tuberous sclerosis complexPrincipal Investigator

    • Principal Investigator
      Kobayashi Toshiyuki
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Juntendo University
  •  Investigation on the pathomechanism of autism spectrum disorder associated with hyperactivated mTOR signaling pathway

    • Principal Investigator
      Atsushi Sato
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      The University of Tokyo
      Tokyo Metropolitan Institute of Medical Science
  •  The mechanism of loss of Erc gene ameliorates renal carcinogenesis and modulates integrin related pathway

    • Principal Investigator
      ZHANG Danqing
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Juntendo University
  •  Elucidation of signal transduction systems which are regulated by BHD tumor suppressor proteinPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Toshiyuki
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Juntendo University
  •  The functional analysis of Erc gene encoding GPI anchor protein

    • Principal Investigator
      ZHANG Danqing
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Juntendo University
  •  Elucidation of tumor suppressor function of Birt-Hogg-Dube syndrome gene(BHD)Principal Investigator

    • Principal Investigator
      KOBAYASHI Toshiyuki
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Juntendo University
  •  The study of multistep carcinogenesis using unique animal models

    • Principal Investigator
      HINO Okio
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University
  •  Abnormality of sugar/amino acid transport and ATP sensor in renal carcinogenesisPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Toshiyuki
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Juntendo University
  •  Functional analysis of tuberin by using animal models of tumor suppressor Tsc2-mutant.Principal Investigator

    • Principal Investigator
      KOBAYASHI Toshiyuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Japanese Foundation for Cancer Research
  •  癌抑制遺伝子Tscl産物の機能解析Principal Investigator

    • Principal Investigator
      小林 敏之
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
  •  Multi-step carcinogenesis using genetically retired models

    • Principal Investigator
      HINO Okio
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Juntendo University School of Medfcine
      Japanese Foundation For Cancer Research
  •  Functional analysis of hamartin by use of Tscl knockout mice.Principal Investigator

    • Principal Investigator
      KOBAYASHI Toshiyuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Multistage carcinogenesis in TSC gene mutant models

    • Principal Investigator
      HINO Okio
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Cancer Institute Carcinogenesis
  •  Functional analysis of Tsc2 gene product by conditional gene targeting.Principal Investigator

    • Principal Investigator
      KOBAYASHI Toshiyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      The Japanese Foundation for Cancer Research
  •  Pathogenesis of Human Tuberous Sclerosis

    • Principal Investigator
      HINO Okio
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Cancer Institute
  •  Generation of the wild-type Tsc2 transgenic Eker rat and its effect on renal carcinogenesis.Principal Investigator

    • Principal Investigator
      KOBAYASHI Toshiyuki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory animal science
    • Research Institution
      Japanese Foundation for Cancer Research
  •  遺伝性腎癌ラットの発癌機構の解明

    • Principal Investigator
      樋野 興夫
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Japanese Foundation For Cancer Research
  •  遺伝子組換え修復に関与するRAD51相同遺伝子導入マウスを用いた肝発癌の研究Principal Investigator

    • Principal Investigator
      小林 敏之
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Japanese Foundation For Cancer Research
  •  Isolation of the predisposing gene of the Eker rat model of hereditary renal cell carcinoma

    • Principal Investigator
      HINO Okio
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Laboratory animal science
    • Research Institution
      Cancer Institute
  •  遺伝性腎癌ラット繁殖システムの確立と発癌機構の解明

    • Principal Investigator
      HINO Okio
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research

All 2020 2019 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 Other

All Journal Article Presentation Book

  • [Book] Cancer : Cell Structures, Carcinogens and Genomic Instability.2006

    • Author(s)
      Hino O., Kobayashi T., Okimoto K.
    • Total Pages
      24
    • Publisher
      Birkhauser Verlag
    • Data Source
      KAKENHI-PROJECT-17013076
  • [Book] Cancer : Cell Structures,Carcinogens and Genomic Instability.2006

    • Author(s)
      Hino, O, Kobayashi, T, Okimoto,K
    • Publisher
      Birkhauser Verlag
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590256
  • [Book] Cancer : Cell Structures, Carcinogens and Genomic Instability.2006

    • Author(s)
      Hino, O, Kobayashi, T, Okimoto, K
    • Publisher
      Birkhauser Verlag
    • Data Source
      KAKENHI-PROJECT-16590256
  • [Book] Cancer : Cell Structures, Carinogenes and Genomic Instability.2005

    • Author(s)
      Hino O., Kobayashi T., Okimoto K.
    • Publisher
      Birkhauser Verlag
    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Interstitial chromosomal deletion of the Tsc2 locus is a signature for radiation-associated renal tumors in Eker rats2020

    • Author(s)
      Tatsuya Inoue, Toshiaki Kokubo, Kazuhiro Daino, Hiromi Yanagihara, Fumiko Watanabe, Chizuru Tsuruoka, Yoshiko Amasaki, Takamitsu Morioka, Shino Homma-Takeda, Toshiyuki Kobayashi, Okio Hino, Yoshiya Shimada, Shizuko Kakinuma
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 3 Pages: 840-848

    • DOI

      10.1111/cas.14307

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01938, KAKENHI-PROJECT-17K08670
  • [Journal Article] Predictive markers for efficacy of everolimus plus exemestane in patients with luminal HER2-negative metastatic breast cancer2018

    • Author(s)
      Okazaki M, Horimoto Y, Tanabe M, Ichikawa Y, Tokuda E, Arakawa A, Kobayashi T, Saito M
    • Journal Title

      Med Oncol

      Volume: 35 Issue: 4 Pages: 48-48

    • DOI

      10.1007/s12032-018-1112-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460398
  • [Journal Article] Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex2017

    • Author(s)
      Kobayashi T, Hino O
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 1 Pages: 5-11

    • DOI

      10.1111/cas.13116

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460398
  • [Journal Article] Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway.2015

    • Author(s)
      Kawano H, Ito Y, Kanai F, Nakamura E, Tada N, Takai S, Horie S, Kobayashi T, Hino
    • Journal Title

      Oncol Rep

      Volume: 34 Issue: 5 Pages: 2251-2258

    • DOI

      10.3892/or.2015.4254

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26430207, KAKENHI-PROJECT-26460398
  • [Journal Article] Tsc2 haploinsufficiency is associated with more severe autism-related behavioral deficits in mouse models of tuberous sclerosis complex2015

    • Author(s)
      佐藤敦志、高松幸雄、笠井慎也、小林敏之、樋野興夫、池田和隆、水口雅
    • Journal Title

      日本神経精神薬理学会雑誌

    • Data Source
      KAKENHI-PROJECT-26860836
  • [Journal Article] Establishiment of Tsc2-deficient rat embryonic stem cells.2015

    • Author(s)
      Ito Y., Kawano H., Kanai F., Nakamura E., Tada N., Takai S., Horie S., Arai H., Kobayashi T. & Hino O.
    • Journal Title

      Int. J. Oncology

      Volume: 46 Issue: 5 Pages: 1944-1952

    • DOI

      10.3892/ijo.2015.2913

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25670196, KAKENHI-PROJECT-26460398, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26430207
  • [Journal Article] JSNP Excellent Presentation Award for CINP2014: Tsc2 haploinsufficiency is associated with more severe autism-related behavioral deficits in mouse models of tuberous sclerosis complex2015

    • Author(s)
      Sato A, Takamatsu Y, Kasai Y, Kobayashi S, Hino T, Ikeda K, Mizuguchi M.
    • Journal Title

      日本神経精神薬理学会雑誌

      Volume: 35 Pages: 51-52

    • Data Source
      KAKENHI-PROJECT-26860836
  • [Journal Article] 結節性硬化症モデルマウスの自閉症様行動におけるmTORシグナル系の関与2014

    • Author(s)
      佐藤敦志、笠井慎也、小林敏之、高松幸雄、樋野興夫、池田和隆、水口雅
    • Journal Title

      日本神経精神薬理学会雑誌

      Volume: 34 Pages: 51-52

    • Data Source
      KAKENHI-PROJECT-26860836
  • [Journal Article] Tuberin activates and controls the distribution of Rac1 viaassociation with p62 and ubiquitinthrough the mTORC1 signaling pathway2013

    • Author(s)
      Okura H, Kobayashi T, Zhang D, Hino O, et al
    • Journal Title

      Int J Oncol

      Volume: 2 Pages: 5-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500389
  • [Journal Article] Folliculin regulates cyclin D1 expression through cis-acting elements in the 3' untranslated region of cyclin D1 mRNA2013

    • Author(s)
      Kawai A, Kobayashi T, Hino O
    • Journal Title

      Int J Oncol

      Volume: 42(5) Issue: 5 Pages: 1597-604

    • DOI

      10.3892/ijo.2013.1862

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500389
  • [Journal Article] TSC1 controls distribution of actin fibers through its effect on function of Rho family of small GTPases and regulates cell migration and polarity2013

    • Author(s)
      Ohsawa M, Kobayashi T, Hino O, et al
    • Journal Title

      PLoS One

      Volume: 8(1) Issue: 1 Pages: e54503-e54503

    • DOI

      10.1371/journal.pone.0054503

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500389, KAKENHI-PROJECT-24659490, KAKENHI-PROJECT-25670196
  • [Journal Article] Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice2011

    • Author(s)
      Zhang D, Kobayashi T, Hino O, et al
    • Journal Title

      Cancer Sci

      Volume: 102(4) Issue: 4 Pages: 720-7

    • DOI

      10.1111/j.1349-7006.2011.01846.x

    • NAID

      10029291977

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500389, KAKENHI-PROJECT-23510244
  • [Journal Article] Age dependence of radiation-induced renal cell carcinomas in an Eker rat model.2010

    • Author(s)
      Kokubo T., Kakinuma S., Kobayashi T., Watanabe F., Iritani R., Tateno K., Nishimura M., Nishikawa T., Hino O., Shimada Y.
    • Journal Title

      Cancer Sci. 101

      Pages: 616-623

    • NAID

      10026589138

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Serine 62 is phosphorylation site in folliculin, the Birt-Hogg-Dube gene product.2010

    • Author(s)
      Wang L., Kobayashi T., Piao X., Shiono M., Takagi Y., Mineki R., Taka H., Zhang D., Abe M., Son G., Hagiwara Y., Okimoto K., Matsumoto I., Kouchi M., Hino O.
    • Journal Title

      FEBS Letters 584

      Pages: 39-43

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubegene product2010

    • Author(s)
      Wang L, Kobayashi T, Zhang D, Hino O, et al
    • Journal Title

      FEBS Lett

      Volume: 584(1) Issue: 1 Pages: 39-43

    • DOI

      10.1016/j.febslet.2009.11.033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500389
  • [Journal Article] Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.2010

    • Author(s)
      Kunogi M, Kurihara M, Ikegami TS, Kobayashi T, Shindo N, Kumasaka T, Gunji Y, Kikkawa M, Iwakami S, Hino O, Takahashi K, Seyama K
    • Journal Title

      J Med Genet 47

      Pages: 281-287

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Journal Article] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization2010

    • Author(s)
      Inoue H, Hino O, Kobayashi T, et al
    • Journal Title

      iochem Biophys Res Commun

      Volume: 391(1) Issue: 1 Pages: 1148-53

    • DOI

      10.1016/j.bbrc.2009.12.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22500389
  • [Journal Article] Phosphorylated hamartin-Hsp70 complex regulates apoptosis via mitochondrial localization.2010

    • Author(s)
      Inoue H., Uyama T., Suzuki T., Kazami M., Hino O., Kobayashi T., Kobayashi K., Tadokoro T.
    • Journal Title

      Biochem. Biophys. Res. Commun. 391

      Pages: 1148-1153

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Age dependence of radiation-induced renal cell carcinomas in an Eker rat model2010

    • Author(s)
      T. Kokubo, S. Kakinuma, M. Nishimura, Y. Shimada, et. Al
    • Journal Title

      Cancer Science

      Volume: 101(3) Issue: 3 Pages: 616-623

    • DOI

      10.1111/j.1349-7006.2009.01456.x

    • NAID

      10026589138

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21610029, KAKENHI-PROJECT-22500389
  • [Journal Article] Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product.2010

    • Author(s)
      Wang L, Kobayashi T, Piao X, Shiono M, Takagi Y, Mineki R, Taka H, Zhang D, Abe M, Sun G, Hagiwara Y, Okimoto K, Matsumoto I, Kouchi M, Hino O
    • Journal Title

      FEBS Lett 584

      Pages: 39-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Journal Article] Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway.2009

    • Author(s)
      Piao X., Kobayashi T., Wang L., Shiono M., Takagi Y., Sun G., Abe M., Hagiwara Y., Zhang D., Okimoto K., Kouchi M., Matsumoto I., Hino O.
    • Journal Title

      Biochem. Biophys. Res. Commun. 389

      Pages: 16-21

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Regulation of folliculin (the BHD gene product) phosphorylation by Tsc2-mTOR pathway.2009

    • Author(s)
      Piao X, Kobayashi T, Wang L, Shiono M, Takagi Y, Sun G, Abe M, Hagiwara Y, Zhang D, Okimoto K, Kouchi M, Matsumoto I, Hino O
    • Journal Title

      Biochem Biophys Res Commun 389

      Pages: 16-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Journal Article] Biphasic response of pancreatic β cell mass to ablation of TSC2 mice.2008

    • Author(s)
      Shigeyama Y., Kobayashi T., Kido Y., Hashimoto N., Asahara S., Matsuda T., Takeda A., Inoue T., Shibutani Y., Koyanagi M., Uchida T., Inoue M., Hino O., Kasuga M., Noda T.
    • Journal Title

      Mol. Cell. Biology 28

      Pages: 2971-2979

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model.2008

    • Author(s)
      Imamura O., Okada H., Takashima Y., Zhang D., Kobayashi T., Hino O.
    • Journal Title

      Cancer Letters 268

      Pages: 278-285

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition.2008

    • Author(s)
      Shiono M., Kobayashi T., Takahashi R., Sun G., Abe M., Zhang D., Wang L., Piao X., Takagi Y., Mineki R., Taka H., Tada N., Sonobe S., Momose S., Ueda M., Hino O.
    • Journal Title

      Oncogene 27

      Pages: 6690-6697

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.2008

    • Author(s)
      Takagi Y, Kobayashi T, Shiono M, Wang L, Piao X, Sun G, Abe M, Hagiwara Y, Takahashi K, Hino O
    • Journal Title

      Oncogene 27

      Pages: 5339-5347

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Journal Article] Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Racl activation.2008

    • Author(s)
      Suzuki T., Das S.K., Inoue H., Kazami M., Hino O., Kobayashi T., Yeung R.S., Kobayashi K., Tadokoro T., Yamamoto Y.
    • Journal Title

      Biochem. Biophys. Res. Commun 368

      Pages: 132-137

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Sensitive and specific new enzyme-linked immunosorbent assay for N-ERC/mesothelin increases its potential as a useful serum tumor marker for mesothelioma.2008

    • Author(s)
      Shiomi K., Hagiwara Y., Sonoue K., Segawa T., Miyashita K., Maeda M., Izumi H., Masuda K., Hirabayashi M., Moroboshi T., Yoshiyama T., Ishida A., Natori Y., Inoue A., Kobayashi M., Sakao Y., Miyamoto H., Takahashi K., Hino O.
    • Journal Title

      Clinical Cancer Res. 14

      Pages: 1431-1437

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnipl-like (FnipL/Fnip2) protein.2008

    • Author(s)
      Takagi Y., Kobayashi, T., Shiono M., Wang L., Piao X., Sun G., Zhang D., Abe M., Hagiwara Y., Takahashi K., Hino O.
    • Journal Title

      Oncogene 27

      Pages: 5339-5347

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] The endoplasmic reticulum stress-inducible protein Niban regulates eIF2 α and S6K1/4E-BP1 phosphorylation.2007

    • Author(s)
      Sun G.D., Kobayashi T., Abe M., Tada N., Adachi H., Shiota A., Totsuka Y., Hino O.
    • Journal Title

      Biochem. Biophys. Res. Commun 360

      Pages: 181-187

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] GADD34 inhibits mammalian target of rapamycin signaling via tubero us sclerosis complex and controls cell survival under bioenergetic stress.2007

    • Author(s)
      Watanabe R, Tambe Y, Inoue H, Isono T, Haneda M, Isobe K, Kobayashi T, Hino O, et al.
    • Journal Title

      Int J Mol Med. 19・3

      Pages: 475-83

    • Data Source
      KAKENHI-PROJECT-18500330
  • [Journal Article] Suppression of viral replication by stress-inducible GADD34 protein via the mammalian serine/threonine protein kinase mTOR pathway.2007

    • Author(s)
      Minami K., Tambe Y., Watanabe R., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T., Inoue H.
    • Journal Title

      J. Virology 81

      Pages: 11106-11115

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo N-terminal hamartin-binding and C-termin.2007

    • Author(s)
      Momose S., Kobayashi T., Tada N., Itoyama S., Hino O.
    • Journal Title

      Biochem. Biophys. Res. Commun 356

      Pages: 693-698

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] GADD34 inhibits mammalian target of repamycin signaling via tuberous sclerosis complex and controls cell surbival under bioenergetic stress.2007

    • Author(s)
      Watanabe R., Tambe Y., Inoue H., Isono T., Haneda M., Isobe K., Kobayashi T., Hino O., Okabe H., Chano T.
    • Journal Title

      Int. J. Molecular Medicine 19

      Pages: 475-483

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.2006

    • Author(s)
      Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
    • Journal Title

      Oncogene 25

      Pages: 2885-2889

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.2006

    • Author(s)
      Togashi, Y, Kobayashi, T, et al.
    • Journal Title

      Oncogene (In press)

    • Data Source
      KAKENHI-PROJECT-16590256
  • [Journal Article] A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis.2006

    • Author(s)
      Matsumoto F., Fujii H., Abe M., Kajino K., Kobayashi T., Matsumoto T., Ikeda K., Hino O.
    • Journal Title

      Human Pathology 37

      Pages: 1592-1600

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation.2006

    • Author(s)
      Chano T., Saji M., Inoue H., Minami K., Kobayashi T., Hino O., Okabe H.
    • Journal Title

      Int. J. Molecular Medicine 18

      Pages: 425-432

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.2006

    • Author(s)
      Togashi Y, Kobayashi T, Momose S, et al.
    • Journal Title

      Oncogene 25

      Pages: 2885-2889

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.2006

    • Author(s)
      Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, et al.
    • Journal Title

      J Biol Chem. 281・52

      Pages: 40242-51

    • Data Source
      KAKENHI-PROJECT-18500330
  • [Journal Article] Intraction of Fox01 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway.2006

    • Author(s)
      Cao Y., Kamioka Y., Yokoi N., Kobayashi T., Hino O., Onodera M., Mochizuki N., Nakae J.
    • Journal Title

      J. Biological Chemistry 281

      Pages: 40242-40251

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] A germline insertion in the Birt-Hogg-Dube' (BHD) gene gives rise to the Nihon Rat model of inherited renal cancer.2004

    • Author(s)
      Okimoto K., Sakurai J., Kobayashi T., Mitani H., Hirayama Y., Nickerson M.L., Warren M.B., Zbar B., Schmidt L.S., Hino 0.
    • Journal Title

      Proc Natl Acad Sci USA 101

      Pages: 2023-2027

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] The Niban gene is commonly expressed in renal tumors : A new candidate marker for renal carcinogenesis.2004

    • Author(s)
      Adachi H., Majima S., Kon S., Kobayashi T., Kajino K., Mitani H., Shiina H., Igawa M., Hino O.
    • Journal Title

      Oncogene 23

      Pages: 3495-3500

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene.2003

    • Author(s)
      Honda S., Kobayashi T., Kajino K., Urakami S., Igawa M., Hino 0.
    • Journal Title

      Mo1 Carcinog 37

      Pages: 122-129

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] Renal carcinogenesis : genotype, phenotype and dramatype.2003

    • Author(s)
      Hino 0., Kobayashi T., Momose S., Kikuchi Y., Adachi H., Okimoto K.
    • Journal Title

      Cancer Sci 94

      Pages: 142-147

    • NAID

      10016247074

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling.2002

    • Author(s)
      Gao, X., Zhang, Y., Arrazola, P., Hino, 0., Kobayashi, T., Yeung, R.S., Ru, B., Pan, D.
    • Journal Title

      Nature Cell Biology 4

      Pages: 699-704

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] Identification of the coding sequences responsible for Tsc 2-mediated tumor suppression using a transgenic rat system.2002

    • Author(s)
      Momose, S., Kobayashi, T., Mitani, H., Hirabayashi, M., Ito, K., Ueda, M., Nabeshima, Y., Hino, 0.
    • Journal Title

      Human Molecular Genetics, 11

      Pages: 2997-3006

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.2001

    • Author(s)
      Kobayashi, T.et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 98

      Pages: 8762-8767

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] Multistep renalcarcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model-genotype, phenotype and environment.2001

    • Author(s)
      Hino, 0., Majima, S., Kobayashi, T., Honda, S., Momose, S., Kikuchi, Y., Mitani, H.
    • Journal Title

      Mutation Res 477

      Pages: 155-164

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] A germ-line Tscl mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice.2001

    • Author(s)
      Kohayashi, T., Minowa, 0., Sugitani, Y., Takai, S., Mitani, H, Kobayashi, E, Noda, T., Hino, 0.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 98

      Pages: 8762-8767

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213139
  • [Journal Article] Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.

    • Author(s)
      Togashi Y, Kobayashi T, Momose S, Ueda M, Okimoto K, Hino O
    • Journal Title

      Oncogene (in press)

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Journal Article] Clinical and genetic spectrum of Birt-Hogg-Dube syndrome patients in whom pneumothorax and/or multiple lung cysts are the presenting feature.

    • Author(s)
      Kunogi M., Kurihara M., Shigihara-Ikegami T., Kobayashi T., Shindo N., Kumasaka T., Gunji Y., Kikkawa M., Iwakami S., Hino O., Takahashi K., Seyama K.
    • Journal Title

      J. Med. Genetics (in press)

    • Data Source
      KAKENHI-PROJECT-17013076
  • [Presentation] A novel method for highly sensitive, facile and inexpensive quantitative assessment of aberrant DNA methylation in liquid biopsies2020

    • Author(s)
      Sachio Nomura, Toshiyuki Kobayashi, Kiichi Sugimoto, Masami Arai, Kazuhiro Sakamoto, Thomas R. Pisanic II, Okio Hino.
    • Organizer
      AACR Annual Meeting 2020
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K07153
  • [Presentation] Gene expression profile in the liver of Tsc2 heterozygous mutant (Tsc2+/-) mice: Implications of heterozygosity on lipid metabolism2019

    • Author(s)
      Doan Nguyen Minh Thien, Toshiyuki Kobayashi, Keiko Nishikawa, Yoshinobu Sugitani, Takayuki Kitano, Masashi Mizuguchi, Okio Hino
    • Organizer
      2019 International Tuberous Sclerosis Complex Research Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08670
  • [Presentation] Bcat1阻害剤はTsc2欠損マウス腫瘍細胞の増殖を効果的に抑える2019

    • Author(s)
      Keiko NISHIKAWA, Tetsuya TAKAGAKI, Moe YASHIMA, Takumi SUZUKI, Toshiyuki KOBAYASHI
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08670
  • [Presentation] Aberrant histone methylation and altered gene expression in Tsc2-deficient Eker rat ES cells2018

    • Author(s)
      Keiko Nishikawa, Toshiyuki Kobayashi, Yoshinobu Sugitani, Doan Nguyen Minh Thien, Takayuki Kitano, Okio Hino
    • Organizer
      International Tuberous Sclerosis Complex Research Conference 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08670
  • [Presentation] Tsc2欠損EkerラットES細胞にみられるヒストンのメチル化異常及び遺伝子発現異常2018

    • Author(s)
      西川桂子、小林敏之、杉谷喜信、Nguyen Minh Thien Doan、北野隆之、樋野興夫
    • Organizer
      第41回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08670
  • [Presentation] Exploring downstream pathways of Erc/Msln as therapeutic targets of TSC2018

    • Author(s)
      Kobayashi T
    • Organizer
      International Tuberous Sclerosis Complex Research Conference 2018
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08670
  • [Presentation] ハマルチンによるアミノ酸アミノ基転移酵素の制御2018

    • Author(s)
      小林敏之、樋野興夫
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08670
  • [Presentation] Hamartinによる代謝関連遺伝子発現制御2017

    • Author(s)
      小林敏之、樋野興夫
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08670
  • [Presentation] Exploring TSC protein complex/mTORC1-regulated genes in tumor cell lines derived from the Tsc1 knockout mouse2017

    • Author(s)
      Kobayashi T, Hino O
    • Organizer
      2017 International Research Conference on TSC and LAM
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08670
  • [Presentation] ラット由来Tsc2欠損ES細胞にみられるエピゲノム・遺伝子発現異常2017

    • Author(s)
      川桂子、小林敏之、樋野興夫
    • Organizer
      第40回日本分子生物学会年会(2017年度生命科学系学会合同年次大会
    • Data Source
      KAKENHI-PROJECT-26460398
  • [Presentation] Tsc2欠損ES細胞を用いた結節性硬化症関連腫瘍発生のモデリング2016

    • Author(s)
      小林敏之、小橋(張)丹青、樋野興夫
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26460398
  • [Presentation] Exploring the aberrant epigenetic regulation in tuberous sclerosis-associated pathologies using Tsc2-deficient rat embryonic stem cells2016

    • Author(s)
      Kobayashi T, Hino O
    • Organizer
      International Tuberous Sclerosis Complex Research Conference 2016
    • Place of Presentation
      リスボン
    • Year and Date
      2016-11-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460398
  • [Presentation] Tsc2ヘテロ遺伝子欠損による脳内遺伝子発現変化の網羅的解析2015

    • Author(s)
      笠井慎也、佐藤敦志、柏井洋文、小林敏之、樋野興夫、水口雅、池田和隆
    • Organizer
      第45回日本神経精神薬理学会 第37回日本生物学的精神医学会 合同年会
    • Place of Presentation
      東京
    • Year and Date
      2015-09-24
    • Data Source
      KAKENHI-PROJECT-26860836
  • [Presentation] Tsc2 haploinsufficiency causes more severe autistic-like behavioral deficit than Tsc1 in mice.2015

    • Author(s)
      Sato A, Tanaka M, Takamatsu Y, Kasai S, Kobayashi T, Hino O, Ikeda K, Mizuguchi M.
    • Organizer
      13th Asian and Oceanian Congress of Child Neurology
    • Place of Presentation
      台北
    • Year and Date
      2015-05-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860836
  • [Presentation] Tsc2欠損細胞の増殖をrapamycinと協調的に抑制するシグナル阻害剤の探索2015

    • Author(s)
      北野隆之、小林敏之、小橋(張)丹青、樋野興夫
    • Organizer
      第38回日本分子生物学会年会/第39回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-03
    • Data Source
      KAKENHI-PROJECT-26460398
  • [Presentation] Tsc2欠損胚性幹細胞の遺伝子発現異常2014

    • Author(s)
      河野春奈、伊藤敬孝、堀江重郎、小林敏之、樋野興夫
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25
    • Data Source
      KAKENHI-PROJECT-26460398
  • [Presentation] 結節性硬化症モデル動物と細胞のシステムを用いた新規腫瘍治療法開発の戦略2014

    • Author(s)
      小林敏之、樋野興夫
    • Organizer
      第2回日本結節性硬化症学会学術総会
    • Place of Presentation
      東京大学
    • Year and Date
      2014-11-15
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460398
  • [Presentation] Tsc2-mTOR axisの異常が関わる病態発生機構2010

    • Author(s)
      小林敏之
    • Organizer
      第40回日本腎臓学会東部学術大会
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Presentation] Functions of mTOR complexes and mTOR-related tumor suppressor proteins (tuberin and folliculin) in differentiation of skeletal muscle cells.2010

    • Author(s)
      小林敏之, ら
    • Organizer
      第33回日本分子生物学会年会第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Presentation] 骨格筋細胞分化における腫瘍抑制遺伝子産物(Flcnおよびtuberin)の役割2010

    • Author(s)
      小林敏之, ら
    • Organizer
      第16回日本家族性腫瘍学会学術総会
    • Place of Presentation
      朱鷺メッセ(新潟市)
    • Year and Date
      2010-07-09
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Presentation] Functions of mTOR complexes and mTOR-related tumor suppressor proteins (tuberin and folliculin) in differentiation of skeletal muscle cells2010

    • Author(s)
      小林敏之、朴香花、正岡亜希子、大倉英浩、大澤麻記、樋野興夫
    • Organizer
      第33日本分子生物学会年会・第83回日本生化学会大会・合同大会
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Presentation] Regulation of complex formation of FLCN-AMPK by FLCN phosphorylation2009

    • Author(s)
      朴香花、王〓、沖本一夫、河内眞美、松本泉美、小林敏之、樋野興夫
    • Organizer
      第32回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Presentation] Fnip蛋白によるfolliculinの局在とリン酸化の調節2008

    • Author(s)
      小林敏之、高木裕美子、樋野興夫
    • Organizer
      第67回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Presentation] Bhd蛋白のリン酸化部位の同定とリン酸化酵素の解明2008

    • Author(s)
      王〓、朴香花、塩野雅俊、高木裕美子、高ひかり、峯木礼子、小林敏之、樋野興夫
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会・合同大会
    • Data Source
      KAKENHI-PROJECT-20590316
  • [Presentation] Characterization of Bhd tumor suppressor gene product(folliculin)2008

    • Author(s)
      Kobayashi, T., et. al.
    • Organizer
      65th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-30
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590380
  • [Presentation] Bhd腫瘍抑制遺伝子産物(folliculin)の性状解析2006

    • Author(s)
      小林 敏之, 他
    • Organizer
      第65回日本癌学会学術総会
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Year and Date
      2006-09-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590380
  • [Presentation] Tsc2 haploinsufficiency is associated with the more severe autism-related behavioral deficits in mouse models of tuberous sclerosis complex

    • Author(s)
      Sato A, Takamatu Y, Kasai S, Kobayashi T, Hino O, Ikeda K, Mizuguchi M
    • Organizer
      29th International College of Neuropsychopharmacology
    • Place of Presentation
      バンクーバー(カナダ)
    • Year and Date
      2014-06-22 – 2014-06-26
    • Data Source
      KAKENHI-PROJECT-26860836
  • [Presentation] 結節性硬化症モデルマウスにおいてTsc2変異はより重度の自閉症様行動と関連する

    • Author(s)
      佐藤敦志、高松幸雄、小林敏之、樋野興夫、水口雅
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Data Source
      KAKENHI-PROJECT-26860836
  • [Presentation] Autistic-like behavioral deficits in mouse models of tuberous sclerosis complex are severer in Tsc2 mutation than in Tsc1 mutation.

    • Author(s)
      Sato A, Takamatu Y, Tanaka M, Kasai S, Kobayashi T, Hino O, Ikeda K, Mizuguchi M
    • Organizer
      53rd Annual Meeting of American College of Neuropsychopharmacology
    • Place of Presentation
      フェニックス(アメリカ)
    • Year and Date
      2014-12-07 – 2014-12-11
    • Data Source
      KAKENHI-PROJECT-26860836
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