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OKUMURA Kenji  奥村 健二

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… Alternative Names

奥村 健一  オクムラ ケンジ

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Researcher Number 40262901
Other IDs
Affiliation (based on the past Project Information) *help 2008 – 2010: Nagoya University, 大学院・医学系研究科, 寄附講座教授
2008: 名古屋大学, 医学部, 寄附講座講師
2007 – 2008: 名古屋大学, 医学部, 寄附講座教授
2003: NAGOYA UNIVERSITY, Graduate School of Medicine, Assistant Professor, 大学院・医学系研究科, 講師
2002: 名古屋大学, 医学部附属病院, 講師
1998 – 1999: 名古屋大学, 医学部, 講師
1997: 名古屋大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine
Keywords
Principal Investigator
Apolipoprotein E / LDL particle size / 心肥大 / lipid signal transduction / ceramide / fatty acid composition / diacylglycerol / carnitine deficiency / cardiac hypertrophy / FK506 … More / カルシニューリン / カルニチン欠損症 / エネルギー産生障害 / 脂質伝達機構 / セラミド / 脂肪酸組成 / ジアシルグリセロール / カルニチン欠乏 / gene polymorphism / Insulin resistance / Hyperinsulinemia / 動脈硬化 / triglyceride / Insulin / Hb Aic / 遺伝子多型 / アポリポプロテインE / LDL粒子サイズ / インスリン抵抗性 / 高インスリン血症 / 血管内皮機能 / アディポネクチン / Heart Failure / Cardiac hypertrophy / Neovascularization / Atherocsclerosis / Remodeling / マトリックスプロテアーゼ / Lipids / JVSマウス / カルニチン / 心不全 / 脂質 … More
Except Principal Investigator
心臓ラプチャー / 心筋細胞 / カテプシン / 心筋リモデリング Less
  • Research Projects

    (4 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (9 People)
  •  Study on cardiac hypertrophy and failure by lipid storagePrincipal Investigator

    • Principal Investigator
      OKUMURA Kenji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Nagoya University
  •  DEFICIENCY OF CATHEPSIN S IMPROVE CARDIAC REMODELING AND FUNCTION AFTER MTOCARDIAL INFARCTION IN THE MOUSE HEART

    • Principal Investigator
      CHENG Xian Wu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Nagoya University
  •  DISORDER OF CARNITINE METABOLISM AND LIPD SIGNAL TRANSDUCTION IN MYOCARDIUMPrincipal Investigator

    • Principal Investigator
      OKUMURA Kenji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      NAGOYA UNIVERSITY
  •  Lipid metabolism in hyperinsulinemia and insulin resistance and atheroscleorosisPrincipal Investigator

    • Principal Investigator
      OKUMURA Kenji
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Nagoya University

All 2010 2009 2008

All Journal Article Presentation

  • [Journal Article] AT1 blockade attenuates atherosclerotic plaque destabilization accompanied by the suppression of cathepsin S activity in apoE-deficient mice.2010

    • Author(s)
      Sasaki T, Kuzuya M, Nakamura K, Cheng XW, Hayashi T, Song H, Hu L, Okumura K, Murohara T, Iguchi A, Sato K.
    • Journal Title

      Atherosclerosis. 210

      Pages: 430-437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Endothelial function for the evaluation of anti-atherosclerotic drugs.2010

    • Author(s)
      Okumura K, Cheng XW.
    • Journal Title

      Hypertens Res. 33

      Pages: 780-781

    • NAID

      10027681423

    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Low folate levels may be an atherogenic factor regardless of homocysteine levels in young healthy nonsmokers.2010

    • Author(s)
      Imamura A, Murakami R, Takahashi R, Cheng XW, Numaguchi Y, Murohara T, Okumura K.
    • Journal Title

      Metabolism. 59

      Pages: 728-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Exercise training stimulates neovasculalization in response to ischemia via PI3K/Akt-dependent HIF-1. reactivation in advanced age.2010

    • Author(s)
      Cheng XW, Kuzuya M, Song H, Inoue A, Hu L, Kim W, Q D, Shi GP, Okumura K, Murohara T.
    • Journal Title

      Circulation. 122

      Pages: 707-716

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Angiotensin II type 1 receptor blockers prevent tumor necrosis factor-alpha-mediated endothelial nitric oxide synthase reduction and superoxide production in human umbilical vein endothelial cells.2010

    • Author(s)
      Kataoka H, Murakami R, Numaguchi Y, Okumura K, Murohara T.
    • Journal Title

      Eur J Pharmacol. 636

      Pages: 36-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Separating the mechanism-based and off-target actions of CETP inhibitors using CETP gene polymorphisms.2010

    • Author(s)
      Sofat R, Hingorani AD, Smeeth L, Humphries SE, Talmud PJ, Cooper J, Shah T, Sandhu MS, Ricketts SL, Boekholdt SM, Wareham N, Khaw KT, Kumari M, Kivimaki M, Marmot M, Asselbergs FW, van der Harst P, Dullaart RP, Navis G, van Veldhuisen DJ, Van Gilst WH, Thompson JF, McCaskie P, Palmer LJ, Arca M, Quagliarini F, Gaudio C, Cambien F, Nicaud V, Poirer O, Gudnason V, Isaacs A, Witteman JC, van Duijn CM, Pencina M, Vasan RS, D'Agostino RB Sr, Ordovas J, Li TY, Kakko S, Kauma H, Savolainen MJ, Kesaniemi YA,Sandhofer A, Paulweber B, Sorli JV, Goto A, Yokoyama S, Okumura K, Horne BD, Packard C, Freeman D, Ford I, Sattar N, McCormack V, Lawlor DA, Ebrahim S, Smith GD, Kastelein JJ, Deanfield J, Casas JP.
    • Journal Title

      Circulation. 121

      Pages: 52-62

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] High serum concentrations of pentosidine, an advanced glycation end product, are associated with low normal value of ankle-brachial index in apparently healthy men.2010

    • Author(s)
      Takahashi R, Imamura A, Yoshikane M, Suzuki M, Murakami R, Cheng XW, Numaguchi Y, Ikeda N, Murohara T, Okumura K.
    • Journal Title

      Metabolism. in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Ca2^+ channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats.2010

    • Author(s)
      Nishizawa T, Cheng XW, Jin Z, Obata K, Nagata K, Hirashiki A, Sasaki T, Noda A, Takeshita K, Izawa H, Shi GP, Kuzuya M, Okumura K, Murohara T.
    • Journal Title

      J Hypertens. 28

      Pages: 1515-1526

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Differentiation Capacity of Endothelial Progenitor Cells Correlates With Endothelial Function in Healthy Young Men.2009

    • Author(s)
      Miura M, Numaguchi Y, Ishii M, Kubota R, Takeuchi T, Imamura A, Murakami R, Kondo T, Okumura K, Murohara T.
    • Journal Title

      Circ J. 73

      Pages: 1324-1329

    • NAID

      10025932869

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats.2009

    • Author(s)
      Yamada T, Nagata K, Cheng XW, Obata K, Saka M, Miyachi M, Naruse K, Nishizawa T, Noda A, Izawa H, Kuzuya M, Okumura K, Murohara T, Yokota M.
    • Journal Title

      Eur J Pharmacol. 615

      Pages: 163-170

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Risk stratification of patients with prior myocardial infarction and advanced left ventricular dysfunction by gated myocardial perfusion SPECT imaging.2009

    • Author(s)
      Morishima I, Sone T, Tsuboi H, Mukawa H, Uesugi M, Morikawa S, Takagi K, Niwa T, Morita Y, Murakami R, Numaguchi Y, Murohara T, Okumura K.
    • Journal Title

      J Nucl Cardiol. 15

      Pages: 631-637

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers.2009

    • Author(s)
      Cheng XW, Okumura K, et al
    • Journal Title

      J Cardiovasc Pharmacol. 54

      Pages: 47-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Renal protective effects and the prevention of contrast-induced nephropathy by atrial natriuretic peptide.2009

    • Author(s)
      Morikawa S, Sone T, Tsuboi H, Mukawa H, Morishima I, Uesugi M, Morita Y, Numaguchi Y, Okumura K, Murohara T.
    • Journal Title

      J Am Coll Cardiol. 53

      Pages: 1040-1046

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Reply to "Renal protective effects and Prevention of contrast-induced nephropathy by atrial natriuretic peptide. Can it work?"2009

    • Author(s)
      Okumura K, Sone T, Morikawa S, Tsuboi H, Mukawa H, Morishima I, Uesugi M, Morita Y, Numaguchi Y, Murohara T.
    • Journal Title

      J Am Coll Cardiol. 54

      Pages: 1193-1194

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Mesenchymal stem cell-based gene therapy with prostacyclin synthaseenhanced neovascularization in hindlimb ischemia.2009

    • Author(s)
      Ishii M, Okumura K, Murakami R., et al.
    • Journal Title

      Atherosclerosis. 206

      Pages: 109-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Long-term administration of nifedipine attenuates cardiac remodeling and diastolic heart failure in hypertensive rats.2009

    • Author(s)
      Yamada T, Cheng XW, Okumura K, et al.
    • Journal Title

      Fur J Pharmacol. 615

      Pages: 163-170

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers.2009

    • Author(s)
      Cheng XW, Okumura K, Kuzuya M, Jin Z, Nagata K, Obata K, Inoue A, Hirashiki A, Takeshita K, Unno K, Harada K, Shi GP, Yokota M, Murohara T.
    • Journal Title

      J Cardiovasc Pharmacol. 54

      Pages: 47-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Circulating malondialdehyde-modified low-density lipoprotein is strongly associated with very small low-density lipoprotein cholesterol concentrations in healthy men2009

    • Author(s)
      Takahashi R, Cheng XW, Okumura K, et al
    • Journal Title

      Clin Chim Acta 399

      Pages: 74-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Microsomal triglyceride transfer protein gene polymorphism strongly influences circulating malondialdehyde-modified low-density lipoprotein2009

    • Author(s)
      Okumura K, Murakami R, Cheng XW, et al.
    • Journal Title

      Metabolism 58

      Pages: 1306-1311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Microsomal triglyceride transfer protein gene polymorphism strongly influences circulating malondialdehyde-modified low-density lipoprotein.2009

    • Author(s)
      Okumura K, Imamura A, Murakami R, Takahashi R, Cheng XW, Numaguchi Y, Murohara T.
    • Journal Title

      Metabolism. 58

      Pages: 1306-1311

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Circulating malondialdehyde-modified low-densitylipoprotein is strongly associated with very small low-density lipoprotein cholesterol concentrations in healthy men.2009

    • Author(s)
      Takahashi R, Imamura A, Yoshikane M, Suzuki M, Cheng XW, Numaguchi Y, Ikeda N, Murohara T, Okumura K.
    • Journal Title

      Clin Chim Acta. 399

      Pages: 74-78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia.2009

    • Author(s)
      Ishii M, Numaguchi Y, Okumura K, Kubota R, Ma X, Murakami R, Naruse K, Murohara T.
    • Journal Title

      Atherosclerosis. 206

      Pages: 109-118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Ablation of angiotensin IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis.2009

    • Author(s)
      Numaguchi Y, Ishii M, Kubota R, Morita Y, Yamamoto K, Matsushita T, Okumura K, Murohara T.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 29

      Pages: 2102-2108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects : the significance of plasma adiponectin levels.2008

    • Author(s)
      Imamura A, Takahashi R, Murakami R, Kataoka H, Cheng XW, Numaguchi Y, Murohara T, Okumura K.
    • Journal Title

      Eur J Endocrinol. 158

      Pages: 189-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects : the significance of plasma adiponectin levels2008

    • Author(s)
      Imamura A, Cheng XW, Okumura K, et al.
    • Journal Title

      Eur J Endocrinol 158

      Pages: 189-195

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment.2008

    • Author(s)
      Cheng XW, Murohara T, Kuzuya M, Izawa H, Sasaki T, Obata K, Nagata K, Nishizawa T, Kobayashi M, Yamada T, Kim W, Sato K, Shi GP, Okumura K, Yokota M.
    • Journal Title

      Am J Pathol. 173

      Pages: 358-369

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Journal Article] Association between cysteine protease cathepsin S activation and left ventricular function and remodeling in hypertensive heart failure rats2008

    • Author(s)
      Cheng XW, Okumura K, et.al.
    • Journal Title

      Chinese Journal of Cardiology 36

      Pages: 51-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590812
  • [Presentation] Superoxide-dependent cathepsin activation system is associated with hypertensive renal remodeling and represents a target for statin.2009

    • Author(s)
      Cheng XW, Okumura K, Sasaki T, Izawa H, Hirashiki Am Nagata K, Kuzuya M, Murohara T
    • Organizer
      Scientific Sections.
    • Place of Presentation
      Orlando, Florida, USA.
    • Year and Date
      2009-11-09
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Presentation] Statin prevents apoptosis in response to oxidative stress and inflammation in atherogenic plaque via enhancement of antiapoptotic protein IAP-2 and Bcl-2 associated with activation of eNOs : implication for plaque stability.2009

    • Author(s)
      成憲武、葛谷雅文、宋海珍、胡莉ナ、佐々木健、井上愛子、中村香江、奥村健二、室原豊明
    • Organizer
      第17回日本血管生物医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-03
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Presentation] Treatment of ApoE-deficient mice with statin inhibits the oxidative stress-dependent lysosomal protease cathepsin activation system : implication for plaque stability.2008

    • Author(s)
      Cheng XW, Kuzuya M, Okumura K, Nakamura K, Inoue A, Sasaki T, Song H, Takeshita K, Kim W, Shi GP, Murohara T
    • Organizer
      Scientific Sections.
    • Place of Presentation
      New Orleans, Louisiana, USA.
    • Year and Date
      2008-11-11
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Presentation] Statin prevents apoptosis in response to oxidative stress in atherogenic plaque via enhancement of antiapoptotic protein IAP-2 : implication for plaque stability.2008

    • Author(s)
      Cheng XW, Okumura K, Hu L, Song H, Inoue A, Kuzuya M, Murohara T
    • Organizer
      5th China-Japan Cardiovascular Forum.
    • Place of Presentation
      Beijing, China.
    • Year and Date
      2008-10-23
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Presentation] Very small low-density lipoprotein cholesterol level is a determinant of arterial stiffness in men with impaired glucose metabolism.2008

    • Author(s)
      Takahashi R, Okumura K, Yoshikane M, Ikeda N, Murohara T
    • Organizer
      European Society of Cardiology, ESC Congress 2008
    • Place of Presentation
      Munich
    • Year and Date
      2008-09-01
    • Data Source
      KAKENHI-PROJECT-20590859
  • [Presentation] Treatment of ApoE-deficient mice with statin inhibits theNADPH oxidase-dependent lysosomal protease cathepsin activation system : implication for plaque stability.2008

    • Author(s)
      Cheng XW, Okumura K, Kuzuya M, Inoue A, Song H, Hu L, Murohara T
    • Organizer
      4^<th>China-Japan Cardiovascular Forum.
    • Place of Presentation
      Beijing, China.
    • Year and Date
      2008-10-19
    • Data Source
      KAKENHI-PROJECT-20590859
  • 1.  CHENG Xian Wu (30378228)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 23 results
  • 2.  MATSUI Hideo (00324434)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  井澤 英夫 (80402569)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KUZUYA Masafumi (10283441)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  NAGATA Kouzou (20378227)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TAKESHITA Kyousuke (70444403)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  MURAKAMI Ryuichiro (20418742)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 8.  IMAI Hajime
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  OGAWA Yasuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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