Oka Toshihiko 岡敏彦

… Alternative Names

OKA Toshihiko 岡敏彦

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Researcher Number	40263321
Other IDs
Affiliation (Current)	2025: 立教大学, 理学部, 教授
Affiliation (based on the past Project Information) *help	2012 – 2024: 立教大学, 理学部, 教授 2013: 九州大学, 医学研究院, 准教授 2011: 九州大学, 准教授 2011: 九州大学, 医学(系)研究科(研究院), 准教授 2007 – 2011: Kyushu University, 医学研究院, 准教授 … More 2010: 九州大学, 大学院・医学研究院, 准教授 2008: 九州大学, 大学院・医学研究院, 准教授 2001: 阪大, 産業科学研究所, 助手 1994 – 2000: Osaka Univ., ISIR-SANKEN,Research Associate, 産業科学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Cell biology / Functional biochemistry / Basic Section 44010:Cell biology-related / Biological Sciences / Cell biology Except Principal Investigator Biological Sciences / Functional biochemistry / Cell biology
Keywords	Principal Investigator ミトコンドリア / 品質管理 / ミトコンドリア品質管理 / クロライドイオン / GATA-GT1 / 組織特異的転写制御 / オルガネラ / 胃粘膜細胞 / リン酸化 / リン酸化修飾 … More / 細胞死 / Parkin / PINK1 / オルガネラ形態 / KLP6 / MICS1 / 形態形成 / ひだ状人工膜 / クリステ構造 / メンブレンモルフォロジー / プロテアソーム / タンパク質の分解 / プロテアソーム分解 / 液胞型ATPase / GATE-GT1 / GT2 / -GT2 / GATA-GT2 … More Except Principal Investigator ATP / ミトコンドリア / 膜融合 / アポトーシス / 膜分裂 / 液胞型ATPase / Fo / F_1 / ATPase / ATP分解 / ATP合成酵素 / ミトコンドリア分裂 / ミトコンドリア融合 / 神経変性疾患 / 膜ダイナミクス / 高分子量GTPase / オルガネラ / lipophilic cation / vacuolar ATPase / bafilomycin / ATP synthase / H^+ ATPase / H^+輸送路 / エネルギー共役機構 / F_O / 脂溶性カチオン / バフィロマイシン / H^+ATPase / ATP hydrolysis / ATP Synthesis / ATP Synthase / 共役機構 / 解媒中心 / 酵素 / H^+輸送 / ATP合成 / hFis1 / ミトコンドリア動態 / Mfn2 / Mfn1 / Fis1 / DRP1 / Mid51 / Mid49 / Mff / Drp1 / オルガネラダイナミクス / GTPase / オルガネラ動態 / ミトコンドリアダイナミクス / 細胞構造・機能 / ミトコンドリア輸送 / 高分子量 GTPase / 蛋白質輸送 / 膜形成 / 低分子量GTPase / 液胞 / 伸長成長 / 酸性コンパートメント / クロライドチャネル / 線虫 / F_0 / プロトンチャネル / F_0F_1ATPase / Cl^-チャネル / プロトン輸送路 / F型ATPase Less

多彩な構成因子が司るPINK1複合体形成とミトコンドリア品質管理の調節機構Principal Investigator
- Principal Investigator
  
  岡敏彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Rikkyo University
Regulation of mitochondrial quality control by cellular signalsPrincipal Investigator
- Principal Investigator
  
  Oka Toshihiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Rikkyo University
Phosphorylation-dependent regulation of mitochondrial functions and quality controlPrincipal Investigator
- Principal Investigator
  
  OKA Toshihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Rikkyo University
PINK1-mediated regulation of mitochondrial morphology and functionsPrincipal Investigator
- Principal Investigator
  
  Oka Toshihiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Rikkyo University
The mechanism of Drp1-dependent mitochondrial fission
- Principal Investigator
  
  MIHARA Katsuyoshi
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Cell biology
- Research Institution
  Kyushu University
Analysis of mitochondrial morphology and movementPrincipal Investigator
- Principal Investigator
  
  OKA Toshihiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Rikkyo University
  Kyushu University
ミトコンドリア分裂・融合因子の作動機序
- Principal Investigator
  
  三原勝芳
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Regulation of mitochondrial dynamics in mammals
- Principal Investigator
  
  MIHARA Katsuyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Kyushu University
ミトコンドリア外膜の生合成と分裂・融合の分子機構
- Principal Investigator
  
  MIHARA Katsuyoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Membrane morphology -An attempt to reconstitute the cristae structure in liposome-Principal Investigator
- Principal Investigator
  
  OKA Toshihiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Cell biology
- Research Institution
  Kyushu University
Analysis of mitochondrial proteins required for regulation of mitochondrial morphologyPrincipal Investigator
- Principal Investigator
  
  OKA Toshihiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Kyushu University
ミトコンドリア外膜タンパク質のプロテアソーム分解とその生理的役割Principal Investigator
- Principal Investigator
  
  岡敏彦
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
様々な酸性環境を作り出す液胞型ATPaseの役割と機能Principal Investigator
- Principal Investigator
  
  岡敏彦
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
線虫における液胞型ATPaseの役割とクロライドイオンによる調節Principal Investigator
- Principal Investigator
  
  岡敏彦
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
胃におけるGATA転写因子の制御機構とクロライドイオン輸送の解析Principal Investigator
- Principal Investigator
  
  岡敏彦
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
マラリア原虫における細胞内小胞輸送の分子機構
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
高等植物における液胞形成の制御と組織構築
- Principal Investigator
  
  和田洋
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
ATP駆動型プロトントランスポーターとCI-チェンネルの構造・機能・協関
- Principal Investigator
  
  二井將光
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
ATP駆動型プロトントランスポーターとCl^-チャンネルの構造・機能・協関
- Principal Investigator
  
  FUTAI Masamitsu
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
胃壁細胞におけるプロトンポンプの転写機構とクロライドイオン輸送の解析Principal Investigator
- Principal Investigator
  
  岡敏彦
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
プロトンポンプの胃壁細胞における特異的転写と細胞内輸送機構の解析Principal Investigator
- Principal Investigator
  
  岡敏彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Mechanism of H^+ transport by H^+ATPase
- Principal Investigator
  
  FUTAI Masamitsu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
Mechanism of Energy Coupling between Catalysis (ATP Synthesis and Hydrolysis) and H^+ Transport in ATP Synthase
- Principal Investigator
  
  FUTAI Masamitsu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University

[Book] 細胞工学(「ミトコンドリア膜構造変化とアポトーシス制御」)2010
- Author(s)
  大寺秀典、岡敏彦
- Data Source
  KAKENHI-PROJECT-20570185
[Journal Article] Neuronal MML-1/MXL-2 regulates systemic aging via glutamate transporter and cell nonautonomous autophagic and peroxidase activity2023
- Author(s)
  Shioda Tatsuya、Takahashi Ittetsu、Ikenaka Kensuke、Fujita Naonobu、Kanki Tomotake、Oka Toshihiko、Mochizuki Hideki、Antebi Adam、Yoshimori Tamotsu、Nakamura Shuhei
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 39
- DOI
  10.1073/pnas.2221553120
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18140, KAKENHI-PROJECT-22KJ2165, KAKENHI-PLANNED-19H05712, KAKENHI-ORGANIZER-21H05144, KAKENHI-PLANNED-21H05145, KAKENHI-PLANNED-21H05147, KAKENHI-PROJECT-22H04982, KAKENHI-PROJECT-21H02428, KAKENHI-PROJECT-21H02473, KAKENHI-PROJECT-23K23878, KAKENHI-PROJECT-23K27172
[Journal Article] Insights into the regulation of mitochondrial functions by protein kinase A-mediated phosphorylation2023
- Author(s)
  Akabane Shiori、Oka Toshihiko
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 175 Issue: 1 Pages: 1-7
- DOI
  10.1093/jb/mvad075
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15107, KAKENHI-PROJECT-23K27172
[Journal Article] TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria2023
- Author(s)
  Shiori Akabane, Kiyona Watanabe, Hidetaka Kosako, Shun-ichi Yamashita, Kohei Nishino, Masahiro Kato, Shiori Sekine, Tomotake Kanki, Noriyuki Matsuda, Toshiya Endo, Toshihiko Oka
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 5 Pages: 112454-112454
- DOI
  10.1016/j.celrep.2023.112454
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03257, KAKENHI-PROJECT-22K15107, KAKENHI-PROJECT-20K06628, KAKENHI-PLANNED-20H05929, KAKENHI-PROJECT-20H05689, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-23K23878, KAKENHI-PROJECT-23K27171
[Journal Article] Localization of myoglobin in mitochondria: implication in regulation of mitochondrial respiration in rat skeletal muscle2021
- Author(s)
  Koma R, Shibaguchi T, Perez-Lopez C, Oka T, Jue T, Takakura H and Masuda K
- Journal Title
  
  Physiol Rep
  
  Volume: 9 Issue: 5
- DOI
  10.14814/phy2.14769
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02158, KAKENHI-PROJECT-20H03257, KAKENHI-PROJECT-17H04755
[Journal Article] The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain2020
- Author(s)
  Nakamura Seiko、Matsui Aiko、Akabane Shiori、Tamura Yasushi、Hatano Azumi、Miyano Yuriko、Omote Hiroshi、Kajikawa Mizuho、Maenaka Katsumi、Moriyama Yoshinori、Endo Toshiya、Oka Toshihiko
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 99-99
- DOI
  10.1038/s42003-020-0832-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03676, KAKENHI-PROJECT-19H03174, KAKENHI-PROJECT-19K21195, KAKENHI-PROJECT-18H02407, KAKENHI-PLANNED-17H06414, KAKENHI-PROJECT-15H05705
[Journal Article] In vitro synthesis of the human calcium transporter Letm1 within cell-sized liposomes and investigation of its lipid dependency2019
- Author(s)
  Okamura Kosuke、Matsushita Shuhei、Kato Yasuhiko、Watanabe Hajime、Matsui Aiko、Oka Toshihiko、Matsuura Tomoaki
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 127 Issue: 5 Pages: 544-548
- DOI
  10.1016/j.jbiosc.2018.11.003
- NAID
  40021891579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03676, KAKENHI-PROJECT-16J00901, KAKENHI-PUBLICLY-19H05423, KAKENHI-PROJECT-17H00888, KAKENHI-PROJECT-17H01880, KAKENHI-PROJECT-17K19236
[Journal Article] Concentration of mitochondrial DNA mutations by cytoplasmic transfer from platelets to cultured mouse cells.2019
- Author(s)
  Ishikawa K, Kobayashi K, Yamada A, Umehara M, Oka T, Nakada K.
- Journal Title
  
  PLoS ONE
  
  Volume: 14 Issue: 3 Pages: 0213283-0213283
- DOI
  10.1371/journal.pone.0213283
- NAID
  120007133505
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04678, KAKENHI-PROJECT-17H03676, KAKENHI-PROJECT-16K18535, KAKENHI-PROJECT-18K06203
[Journal Article] Structural insights into ubiquitin phosphorylation by PINK12018
- Author(s)
  Okatsu Kei、Sato Yusuke、Yamano Koji、Matsuda Noriyuki、Negishi Lumi、Takahashi Akiko、Yamagata Atsushi、Goto-Ito Sakurako、Mishima Masaki、Ito Yutaka、Oka Toshihiko、Tanaka Keiji、Fukai Shuya
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 10382-10382
- DOI
  10.1038/s41598-018-28656-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05887, KAKENHI-PUBLICLY-17H05888, KAKENHI-PLANNED-18H05501, KAKENHI-PROJECT-16H04749, KAKENHI-PROJECT-16H04750, KAKENHI-PROJECT-17H03676, KAKENHI-PROJECT-18H02443, KAKENHI-PROJECT-26000014
[Journal Article] Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology2018
- Author(s)
  A. Matsumura, J. Higuchi, Y. Watanabe, M. Kato, K. Aoki, S. Akabane, T. Endo, and T. Oka
- Journal Title
  
  Febs Letter
  
  Volume: 592 Issue: 2 Pages: 209-218
- DOI
  10.1002/1873-3468.12948
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03676, KAKENHI-PROJECT-16K21473, KAKENHI-PROJECT-15H05705
[Journal Article] Constitutive activation of PINK1 leads to proteasome-mediated and non-apoptotic cell death independently of mitochondrial autophagy2016
- Author(s)
  Akabane, S., Matsuzaki, K., Yamashita, S-I, Arai, K., Okatsu, K., Kanki, T., Matsuda, N., and Oka, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 31 Pages: 16162-16174
- DOI
  10.1074/jbc.m116.714923
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01196, KAKENHI-PUBLICLY-16H01198, KAKENHI-PUBLICLY-16H01384, KAKENHI-PROJECT-26291039, KAKENHI-PROJECT-26440106, KAKENHI-PROJECT-15K18501
[Journal Article] PKAはMIC60のリン酸化を介してPINK1とParkinによるミトコンドリア品質管理を制御する.2016
- Author(s)
  赤羽しおり，岡　敏彦
- Journal Title
  
  実験医学
  
  Volume: 34 Pages: 2689-2692
- Data Source
  KAKENHI-PROJECT-26440106
[Journal Article] PKA regulates PINK1 stability and Parkin recruitment to damaged mitochondria through phosphorylation of MIC60.2016
- Author(s)
  Akabane, S., M. Uno, N. Tani, S. Shimazaki, N. Ebara, H. Kato, H. Kosako, and T. Oka
- Journal Title
  
  Mol. Cell
  
  Volume: 62 Issue: 3 Pages: 371-384
- DOI
  10.1016/j.molcel.2016.03.037
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440106
[Journal Article] ミトコンドリア形態異常と疾患2015
- Author(s)
  岡　敏彦
- Journal Title
  
  医学のあゆみ
  
  Volume: 254 Pages: 447-451
- Data Source
  KAKENHI-PROJECT-26440106
[Journal Article] Unconventional PINK1 localization mechanism to the outer membrane of depolarized mitochondria drives Parkin recruitment2015
- Author(s)
  Okatsu, K., Kimura, M., Oka, T., Tanaka, K., and Matsuda N.
- Journal Title
  
  J Cell Sci
  
  Volume: 128 Pages: 964-978
- DOI
  10.1242/jcs.161000
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26440106, KAKENHI-PUBLICLY-15H01196, KAKENHI-PUBLICLY-26111729, KAKENHI-PROJECT-26650042
[Journal Article] Fis1 acts as mitochondrial recruitment of TBC1D15 that involved in regulation of mitochondrial morphology2013
- Author(s)
  K. Onoue et al.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 126 Issue: 1 Pages: 176-186
- DOI
  10.1242/jcs.111211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370071, KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23770216, KAKENHI-PROJECT-23770231, KAKENHI-PROJECT-24370077, KAKENHI-PROJECT-24657138, KAKENHI-PROJECT-24770099, KAKENHI-PROJECT-24770133
[Journal Article] A dimeric PINK1-containing complex on depolarized mitochondria stimulates Parkin recruitment2013
- Author(s)
  Kei Okatsu, Midori Uno, Fumika Koyano, Etsu Go, Mayumi kimura, Toshihiko Oka, Keiji Tanaka, Noriyuki Matsuda
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 288 Issue: 51 Pages: 36372-84
- DOI
  10.1074/jbc.m113.509653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23687018, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-25112522
[Journal Article] Fis1 acts as mitochondrial recruitment factor for TBC1D15 that involved in regulation of mitochondrial morphology2013
- Author(s)
  K. Onoue, A. Jofuku, R. Ban-Ishihara, T. Ishihara, M. Maeda, T. Koshiba, T. Itoh, M. Fukuda, H. Otera, T. Oka, H. Takano, N. Mizushima, K. Mihara and N. Ishihara
- Journal Title
  
  J. Cell Sci.
  
  Volume: 126 Pages: 176-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657138
[Journal Article] PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria2012
- Author(s)
  K. Okatsu, T. Oka, M. Iguchi, K. Imamura, H. Kosako, N. Tani, M. Kimura, E. Go, F. Koyano, M. Funayama, K. Shiba-Fukushima, S. Sato, H. Shimizu, Y. Fukunaga, H. Taniguchi, M. Kamatsu, N. Hattori, K. Mihara, K. Tanaka, and N. Matsuda
- Journal Title
  
  Nature Communications
  
  Volume: 1016 Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370071
[Journal Article] Fis1 acts as mitochondrial recruitment factor for TBC1D15 that involved in regulation of mitochondrial morphology.2012
- Author(s)
  K. Onoue, A. Jofuku, R. Ban-Ishihara, T. Ishihara, M. Maeda, T. Koshiba, T. Itoh, M. Fukuda, H. Otera, T. Oka, H. Takano, N. Mizushima, K. Mihara and N. Ishihara
- Journal Title
  
  J. Cell Sc
  
  Volume: 126 Pages: 176-185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370071
[Journal Article] Regulation and physiologic function of GTPases in mitochondrial fusion and fission in mammals2012
- Author(s)
  N. Ishihara, H. Otera, T. Oka, and K. Mihara
- Journal Title
  
  Invited Forum Review Article in Antioxidants & Redox Signaling
  
  Volume: 17 Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370071
[Journal Article] Regulation and physiologic function of GTPases in mitochondrial fusion and fission in mammals2012
- Author(s)
  N. Ishihara, H. Otera, T. Oka, and K, Mihara
- Journal Title
  
  Invited Forum Review Article. Antioxid. Redox Signal
  
  Volume: 17(PMID : 22871170) Pages: 1-11
- Data Source
  KAKENHI-PROJECT-24657138
[Journal Article] Regulation and physiologic function of GTPase in mitochondrial fusion and fission in mammals2012
- Author(s)
  N.Ishihara, H.Otera, T.Oka, K.Mihara
- Journal Title
  
  Antioxidants and Redox Signaling
  
  Volume: (Invited review article)(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370071
[Journal Article] PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria2012
- Author(s)
  尾勝圭
- Journal Title
  
  Nature Communications
  
  Volume: 3 Issue: 1 Pages: 1016-1016
- DOI
  10.1038/ncomms2016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-22370042, KAKENHI-PROJECT-22370071, KAKENHI-PROJECT-23570231, KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23687018, KAKENHI-PROJECT-24657138, KAKENHI-PROJECT-24790896, KAKENHI-PLANNED-23111003, KAKENHI-PUBLICLY-23129506, KAKENHI-PUBLICLY-24111557, KAKENHI-PUBLICLY-24113717
[Journal Article] Regulation and physiologic function of GTPase in mitochondrial fusion and fission in mammals2012
- Author(s)
  N.Ishihara, H.Otera, T.Oka, K.Mihara
- Journal Title
  
  Antioxidants and Redox Signaling
  
  Volume: (Invited review article)(in press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22020026
[Journal Article] Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in mammals2012
- Author(s)
  Ishihara, N., H. Otera, T. Oka, and K. Mihara
- Journal Title
  
  Antioxidant & Redox Signaling
  
  Volume: ー Issue: 4 Pages: 389-399
- DOI
  10.1089/ars.2012.4830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570232, KAKENHI-PROJECT-23770231, KAKENHI-PROJECT-24657138
[Journal Article] KLP6, a newly identified kinesin that regulates morphology and transport of mitochondria in neuronal cells.2011
- Author(s)
  Tanaka, K., Sugiura, Y., Ichishita, R., Mihara, K., and Oka, T
- Journal Title
  
  Journal of Cell Science
  
  Volume: 124 Pages: 2457-2465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570232
[Journal Article] KLP6: a newly identified kinesin that regulates the morphology and transport of mitochondria in neuronal cells.2011
- Author(s)
  K. Tanaka, Y. Sugiura, R. Ichisita, K. Mihara and T. Oka
- Journal Title
  
  J. Cell Sci. 124
  
  Pages: 2457-2465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370071
[Journal Article] KLP6, a newly identified kinesin that regulates morphology and transport of mitochondria in neuronal cells2011
- Author(s)
  Tanaka, K., Y. Sugiura, R. Ichishita, K. Mihara and T. Oka.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 124 Pages: 2457-2465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570232
[Journal Article] KLP6, a new kinesin regulating morphology and transport of mitochondria in neuronal cells.2011
- Author(s)
  Tanaka, K., Sugiura, Y., Ichishita, R., Mihara, K., Oka, T.
- Journal Title
  
  J. Cell Sci. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570185
[Journal Article] ミトコンドリア膜構造変化とアポトーシス制御2010
- Author(s)
  大寺秀典、岡敏彦
- Journal Title
  
  細胞工学
  
  Volume: 29 Pages: 438-442
- Data Source
  KAKENHI-PROJECT-20570185
[Journal Article] An RNAi screen for mitochondrial proteins required to maintain the morphology of the organelle in C. elegans.2008
- Author(s)
  Ichishita, R., Tanaka, K., Sugiura, Y., Sayano, T., Mihara, K., Oka, T.
- Journal Title
  
  J. Biochem. 143
  
  Pages: 449-454
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570185
[Journal Article] The mitochondrial protein MICS1 regulates cristae organization and apo ntotic release of cvtochrome c2008
- Author(s)
  T. Oka, et.al.
- Journal Title
  
  Mol Biol. Cell 19
  
  Pages: 958-963
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059024
[Journal Article] Identification of a novel protein MICSI that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c2008
- Author(s)
  Oka, et al
- Journal Title
  
  Mol. Biol. Cell 19
  
  Pages: 2597-2608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570185
[Journal Article] Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with an AAA-ATPase BCS1L.2008
- Author(s)
  Tamai, S., Iida, H., Yokota, S., Sayano, T., Kiguchiya' S., Ishihara, N., Hayashi, J.-I., Mihara, K., Oka, T.
- Journal Title
  
  J.Cell Sci. 121
  
  Pages: 2588-2600
- Data Source
  KAKENHI-PROJECT-20200058
[Journal Article] Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c.2008
- Author(s)
  Oka, T., Sayano, T., Tamai, S., Yokota, S., Kato, H., Fujii, G., Mihara, K.
- Journal Title
  
  Mol. Biol. Cell 19
  
  Pages: 2597-2608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570185
[Presentation] 障害ミトコンドリアにおけるTIM23を介した新たなPINK1活性化機構2023
- Author(s)
  赤羽しおり，渡邊聖菜，遠藤斗志也，岡　敏彦
- Organizer
  第96回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K27172
[Presentation] ミトコンドリア膜透過装置TIM23はPINK1複合体のメンバーとして，脱分極で郵送されるPINK1分解を抑制する2022
- Author(s)
  赤羽しおり, 渡邊聖菜, 小迫秀尊，松田憲之，遠藤斗志也，岡敏彦
- Organizer
  第45回日本分子生物学会大会
- Data Source
  KAKENHI-PROJECT-20H03257
[Presentation] プロテアーゼを介したミトコンドリア品質管理の制御2021
- Author(s)
  赤羽しおり, 渡邊聖菜, 岡敏彦
- Organizer
  第94回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03257
[Presentation] The novel role of TIM23 in mitochondrial quality control2021
- Author(s)
  赤羽しおり,岡敏彦
- Organizer
  Cold Spring Harbor Asia conference, Mitochondria and Metabolism in Health and Disease
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03257
[Presentation] ミトコンドリア品質管理におけるTIM23複合体の新たな役割2019
- Author(s)
  渡邊聖菜，岡　敏彦
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03676
[Presentation] ミトコンドリア品質管理におけるヘキソキナーゼの役割2018
- Author(s)
  加藤雅広，三宅千絢，岡　敏彦
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H03676
[Presentation] ミトコンドリア膜透過装置コアサブユニットTIM23のミトコンドリア品質管理における役割2018
- Author(s)
  渡邊聖菜，岡　敏彦
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17H03676
[Presentation] ミトコンドリア品質管理のcAMP/PKAによる制御機構2017
- Author(s)
  岡　敏彦
- Organizer
  大阪大学蛋白質研究所セミナー「真核細胞のオルガネラ研究最前線」
- Place of Presentation
  大阪大学蛋白質研究所（大阪府吹田市）
- Year and Date
  2017-03-21
- Invited
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] ミトコンドリア形態におけるカルジオリピンの役割2017
- Author(s)
  松村綾香，樋口　准，青木啓悟，岡敏彦
- Organizer
  生命科学系学会合同年次大会ConBio2017
- Data Source
  KAKENHI-PROJECT-17H03676
[Presentation] PKAによるMIC60リン酸化を介したミトコンドリア品質管理の制御機構2017
- Author(s)
  岡　敏彦
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-16
- Invited
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] MIC60 regulates PINK1 actrivation and Parkin recruitment to damaged mitochondria through the cAMP/PKA signaling pathway2016
- Author(s)
  S. Akabane, M. Uno, S. Shimazaki, T. Oka
- Organizer
  American Society for Cell Biology Annual Meeting 2016
- Place of Presentation
  San francisco, CA, USA
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] PINK1とParkinによるミトコンドリア品質管理機構はPKAを介したMIC60のリン酸化により制御されている2016
- Author(s)
  赤羽しおり，宇野碧，島崎俊太，岡　敏彦
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] PINK1 stability and Parkin mitochondrial targeting are regulated by PKA-mediated phosphorylation of MIC602016
- Author(s)
  赤羽しおり，宇野碧，島崎俊太，岡　敏彦
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] MIC60 regulates PINK1 actrivation and Parkin recruitment through cAMP/PKA signaling pathway2016
- Author(s)
  S. Akabane, M. Uno, S. Shimazaki, T. Oka
- Organizer
  Keystone Symposia on Molecular and Cellular Biology "Mitochondrial Dynamics".
- Place of Presentation
  Steamboat Springs, CO, USA
- Year and Date
  2016-04-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] PINK1の活性化とカスパーゼ非依存性の細胞死2015
- Author(s)
  岡　敏彦
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] リン酸化を介したMICOS複合体によるPINK1の活性化の制御機構2015
- Author(s)
  赤羽しおり，宇野碧，島崎俊太，岡　敏彦
- Organizer
  第38回日本分子生物学会年会、第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] MICOS複合体によるPINK1のミトコンドリア標的化の制御機構2015
- Author(s)
  赤羽しおり，宇野碧，島崎俊太，岡　敏彦
- Organizer
  第67回日本細胞生物学会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Year and Date
  2015-06-30
- Invited
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] オルガネラ形態の機能的意義2014
- Author(s)
  岡敏彦
- Organizer
  第1回生命分子科学研究会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23570232
[Presentation] ミトコンドリア形態とクリステ構造の形成機構2014
- Author(s)
  岡　敏彦
- Organizer
  第25回フォーラム・イン・ドージン
- Place of Presentation
  熊本県熊本市熊本ホテルキャッスル
- Year and Date
  2014-11-14
- Invited
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] オルガネラ形態の機能的意義2014
- Author(s)
  岡　敏彦
- Organizer
  第１回生命分子科学研究会
- Place of Presentation
  ホテル甘露の森（北海道）
- Invited
- Data Source
  KAKENHI-PROJECT-23570232
[Presentation] Formation of Cristae Structure in Mammals2013
- Author(s)
  岡　敏彦
- Organizer
  The 4th International Symposium on Dynamics of Mitochondria from Molecular Mechanisms to Physiological Functions and Diseases
- Place of Presentation
  沖縄残波岬ロイヤルホテル（沖縄）
- Invited
- Data Source
  KAKENHI-PROJECT-23570232
[Presentation] Formation of Cristae Structure in Mammals2013
- Author(s)
  Toshihiko Oka.
- Organizer
  The 4^<th> International Symposium on Dynamics of Mitochondria from Molecular Mechanisms to Physiological Functions and Diseases
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-23570232
[Presentation] ミトコンドリア形態とクリステ膜構造の形成機構2012
- Author(s)
  岡敏彦
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23570232
[Presentation] ミトコンドリアの形態形成と軸索移動に関わる新規キネシンの機能解析2010
- Author(s)
  岡敏彦
- Organizer
  日本生化学会日本分子生物学会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20570185
[Presentation] MICS1 is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c2009
- Author(s)
  岡敏彦
- Organizer
  American Society of Cell Biology
- Place of Presentation
  合衆国サンディエゴサンディエゴコンベンションセンター
- Year and Date
  2009-12-06
- Data Source
  KAKENHI-PROJECT-20570185
[Presentation] ミトコンドリアAAA蛋白質とその生理機能2009
- Author(s)
  岡敏彦
- Organizer
  第9回日本蛋白質科学会
- Place of Presentation
  熊本全日空ホテルニュースカイ
- Year and Date
  2009-05-20
- Data Source
  KAKENHI-PROJECT-20570185
[Presentation] ミトコンドリアのクリステ構造の制御因子とその形成機構2009
- Author(s)
  岡敏彦
- Organizer
  第61回日本生化学会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20200058
[Presentation] 新規ミトコンドリアタンパク質MICSIの機能解析2008
- Author(s)
  岡敏彦
- Organizer
  日本細胞生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2008-06-29
- Data Source
  KAKENHI-PROJECT-20570185
[Presentation] Regulation of mitochondrial morphology and cristae organization2008
- Author(s)
  岡敏彦
- Organizer
  日本生化学会・日本分子生物学会合同大会
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20570185
[Presentation] Parkinのミトコンドリア外膜標的化に関わるMICOS複合体の解析
- Author(s)
  宇野碧，岡　敏彦
- Organizer
  第14回日本ミトコンドリア学会
- Place of Presentation
  福岡県福岡市九州大学医学部百年講堂
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-26440106
[Presentation] ミトコンドリア形態とクリステ膜構造の形成機構
- Author(s)
  岡　敏彦
- Organizer
  第85回日本生化学会
- Place of Presentation
  福岡国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-23570232
[Presentation] PINK1/Parkinによるカスパーゼ非依存性細胞死の解析
- Author(s)
  松崎航平，荒井伽奈，尾勝圭，松田憲之，岡　敏彦
- Organizer
  第14回日本ミトコンドリア学会
- Place of Presentation
  福岡県福岡市九州大学医学部百年講堂
- Year and Date
  2014-12-03 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-26440106

1. MIHARA Hidenori (40380612)

# of Collaborated Projects: 5 results

# of Collaborated Products: 8 results
2. FUTAI Masamitsu (50012646)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MIHARA Katsuyoshi (40029963)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
4. 表弘志 (10273707)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 和田洋 (50212329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ISIHARA Naotada (10325516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. IWAMOTO Atsuko (70252715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MORIYAMA Yoshinori (10150658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 田村茂彦 (90236753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 三本木至宏 (10222027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MATSUDA Noriyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中村修平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 中田和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 伊藤隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 増田和実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 尾勝圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 田中啓二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Oka Toshihiko 岡 敏彦

OKA Toshihiko 岡 敏彦

Research Projects

Research Products

Co-Researchers

多彩な構成因子が司るPINK1複合体形成とミトコンドリア品質管理の調節機構Principal Investigator

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Regulation of mitochondrial quality control by cellular signalsPrincipal Investigator

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Phosphorylation-dependent regulation of mitochondrial functions and quality controlPrincipal Investigator

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PINK1-mediated regulation of mitochondrial morphology and functionsPrincipal Investigator

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Analysis of mitochondrial morphology and movementPrincipal Investigator

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Membrane morphology -An attempt to reconstitute the cristae structure in liposome-Principal Investigator

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Analysis of mitochondrial proteins required for regulation of mitochondrial morphologyPrincipal Investigator

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ミトコンドリア外膜タンパク質のプロテアソーム分解とその生理的役割Principal Investigator

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様々な酸性環境を作り出す液胞型ATPaseの役割と機能Principal Investigator

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Research Institution

線虫における液胞型ATPaseの役割とクロライドイオンによる調節Principal Investigator

Oka Toshihiko 岡敏彦

OKA Toshihiko 岡敏彦