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HIROSE MASAMICHI  弘瀬 雅教

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… Alternative Names

弘瀬 雅教  ヒロセ マサミチ

HIROSE Masamichi  弘瀬 雅教

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Researcher Number 40273081
Other IDs
Affiliation (Current) 2025: 岩手医科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2018 – 2020: 岩手医科大学, 薬学部, 教授
2010 – 2016: 岩手医科大学, 薬学部, 教授
2009: Shinshu University, 医学部, 准教授
2002: Shinshu University School of Medicine, Assistant Professor, 医学部, 講師
2001: 信州大学, 医学部, 助手
1999: Shinshu Univ. Sch. Medicine Instructor, 医学部, 助手
Review Section/Research Field
Principal Investigator
General pharmacology / General pharmacology
Except Principal Investigator
General pharmacology / Metabolomics / Basic Section 54040:Metabolism and endocrinology-related / Experimental pathology
Keywords
Principal Investigator
Zatebradine / E-4031 / PACAP / 心室性不整脈 / 心不全 / Autonomic nervous system / Action potential / Atriai fibrillation / Atrial muscle structure / 光学マッピング … More / 活動電位幅 / 心房細動 / 過分極活性化電流 / カリウムチャンネル / カルシウムチャンネル / 自律神経 / 活動電位 / 心房細胞 / 心房筋の三次元構造 / ナトリウム-グルコース共輸送機構1 / ナトリウムーグルコース共輸送機構1 / 心筋肥大 / 急性虚血 / 高血圧症 / SGLT1 / SK&F96365 / 早期後脱分極 / TRPCチャネル / 血液 / 心血管 … More
Except Principal Investigator
心房細動 / 不整脈 / 脂肪滴 / 脂肪毒性 / PACAP / コネキシン43 / gap junction / 脂肪心筋 / コネキシン / Gap junction / コネキシン43 / リピッドシグナル / リモデリング / 脂質シグナル / Perilipin2 / Connexin43 / Connexin 43 / Perilipin 2 / Intracardiac nerve stimulation / Desensitization / Adenosine / Blood-perfused sinus node preparation / Sinus node artery / Isolated canine right atria / 心臓内自律神経刺激 / アセチルコリン / ノルアドレナリン / イヌ洞結節動脈 / 心臓内神経刺激 / 脱感作作用 / アデノシン / 血液灌流洞結節標本 / 洞結節動脈 / 摘出イヌ右心房 / muscarinic receptors / β-adrenoceptors / sinus node / vagal stimulation / parasympathetic nerve / atrial fibrillation / arrhythmia / マッピング / 迷走神経 / ニューペプチド / βアドレナリン受容体 / ムスカリン受容体 / βアドリナリン受容体 / 洞結節 / 迷走神経刺激 / 副交感神経 / ギャップジャンクション / connexin 43 / ApoA-I / コレステロール / アミロイド / 小胞体ストレス / トランスジェニックマウス / ApoA-II / SAA / マウス / 治療 / Apolipoprotein A-II / 線維形成 / 伝播 / アミロイドーシス / 疾患モデル動物 / 線維化 / 心筋症 / エネルギー代謝 / 糖尿病性心筋症 Less
  • Research Projects

    (9 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (14 People)
  •  Cardiac lipid droplets and gap junction remodeling

    • Principal Investigator
      Suzuki Jinya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      University of Fukui
  •  Cardiac steatosis and arrhythmia

    • Principal Investigator
      Suzuki Jinya
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Fukui
  •  Relationship between SGLT1 and ventricular arrhythmiaPrincipal Investigator

    • Principal Investigator
      HIROSE MASAMICHI
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Iwate Medical University
  •  Pathological Investigation of the Pathogenesis and Development of Preventive and Therapeutic Procedures for Amyloidosis

    • Principal Investigator
      HIGUCHI Keiichi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Shinshu University
  •  Function of ADRP in the pathogenesis of diabetic cardiomyopathy

    • Principal Investigator
      SUZUKI Jinya
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      University of Fukui
  •  Roles of TRPC channel activation in the induction of ventricular tachycardiasPrincipal Investigator

    • Principal Investigator
      HIROSE Masamichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Iwate Medical University
      Shinshu University
  •  Pharmacological study of purinergic mechanism for cardiac sinus node pacemaker activity

    • Principal Investigator
      CHIBA Shigetoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Shinshu University
  •  Effects of atrial muscle structure on the initiation mechanism of atrial fibrillation and its drug therapyPrincipal Investigator

    • Principal Investigator
      HIROSE Masamichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Shinshu University
  •  Basic study of mechanism that neuropeptide PACAP induces paroxysmal atrial fibrillation.

    • Principal Investigator
      NAKANE Tokio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Shinshu University

All 2020 2019 2016 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book

  • [Book] Heat shock factor 1 (Hsf1) plays a key role in AApoAII cardiac amyloidosis in mice, Hazenberg B.P.C & Bijzet J eds2013

    • Author(s)
      Qian J, Hirose M, Zhang B, Wang Y, Tian G, Luo H, Liu Y, Fu X, Ge F, Sawashita J, Mori M, Fujimoto M, Nakai A, Higuchi K
    • Publisher
      XIIIth International Symposium on Amyloidosis From Molecular Mechanisms Towards the Cure of Systemic Amyloidosis, Zalsman, Groningen B.V, The Netherlands
    • Data Source
      KAKENHI-PROJECT-23390093
  • [Book] Heat shock factor 1 (Hsf1) plays a key role in AApoAII cardiac amyloidosis in mice. (XIIIth International Symposium on Amyloidosis. From Molecular Mechanisms Towards the Cure of Systemic Amyloidosis)2013

    • Author(s)
      Qian J, Hirose M, Zhang B, Wang Y, Tian G, Luo H, Liu Y, Fu X, Ge F, Sawashita J, Mori M, Fujimoto M, Nakai A, Higuchi K.
    • Total Pages
      496
    • Publisher
      Zalsman
    • Data Source
      KAKENHI-PROJECT-23390093
  • [Journal Article] Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.2019

    • Author(s)
      Sato S, Suzuki J, Hirose M, Yamada M, Zenimaru Y, Nakaya T, Ichikawa M, Imagawa M, Takahashi S, Ikuyama S, Konoshita T, Kraemer FB, Ishizuka T.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 317 Issue: 6 Pages: E1193-E1204

    • DOI

      10.1152/ajpendo.00227.2019

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08471, KAKENHI-PROJECT-17K09726
  • [Journal Article] Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts2014

    • Author(s)
      Masamichi Hirose, Toshihide Shibazaki, Tsutomu Nakada, Toshihide Kashihara, Shiharu Yano, Yoshie Okamoto, Masayuki Isaji, Naoko Matsushita, Eiichi Taira, Mitsuhiko Yamada
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: 37

    • NAID

      130004057424

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590326
  • [Journal Article] Diacylglycerol kinaseζinhibits ventricular tachyarrhythmias in a mou-se model of heart failure : Roles of canonical transient receptor potential(TRPC) channels2011

    • Author(s)
      Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubotac I, Mende U, Yamada M.
    • Journal Title

      Circ J

      Volume: 75 Pages: 2333-2342

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Journal Article] Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure : Roles of canonical transient receptor potential (TRPC) channels2011

    • Author(s)
      Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubotac I, Mende U, Yamada M
    • Journal Title

      Circulation Journal

      Volume: 75 Pages: 2333-2342

    • NAID

      10029459214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Journal Article] 心不全誘発モデルマウスに対するニコランジル慢性投与の効果2010

    • Author(s)
      弘瀬雅教、堀内美和、中田勉、柏原俊英、矢野志春、柴崎利英、生暁娜、山田充彦
    • Journal Title

      Ther Res

      Volume: 31 Pages: 288-290

    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] GLP1受容体作動薬はPerilipin2過剰発現による脂肪心筋マウスの心房細動を抑制する2020

    • Author(s)
      佐藤さつき, 鈴木仁弥, 東慎一郎, 杉山光寿, 帰山沙織, 古谷真知, 中屋隆裕,山田実夏, 市川麻衣, 斉藤理恵, 今川美智子, 銭丸康夫, 弘瀬雅教, 石塚 全, 此下忠志
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-18K08471
  • [Presentation] Perilipin2過剰発現による脂肪心筋マウスの心房細動はGLP1受容体作動薬により抑制される2020

    • Author(s)
      佐藤さつき, 鈴木仁弥, 弘瀬雅教, 東慎一郎, 杉山光寿, 古谷真知, 帰山沙織,中屋隆裕, 山田実夏, 市川麻衣, 斉藤理恵, 今川美智子, 銭丸康夫, 此下忠志, 石塚 全
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-18K08471
  • [Presentation] 心筋特異的Perilipin2過剰発現マウスにおける“脂肪心筋”のlipidome解析2016

    • Author(s)
      佐藤 さつき, 鈴木 仁弥, 中屋隆裕, 山田実夏, 市川麻衣, 山本勝司, 今川美智子, 藤井美紀, 銭丸康夫, 生山祥一郎, 弘瀬 雅教, 高橋貞夫, 石塚 全, 此下忠志
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26461360
  • [Presentation] Perilipin2過剰発現マウスにおける“脂肪心筋”のlipidome解析2016

    • Author(s)
      佐藤 さつき, 鈴木 仁弥, 中屋隆裕, 山田実夏, 市川麻衣, 山本勝司, 今川美智子, 藤井美紀, 銭丸康夫, 生山祥一郎, 弘瀬 雅教, 高橋貞夫, 此下忠志, 石塚 全
    • Organizer
      第48回 日本動脈硬化学会 総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-07-14
    • Data Source
      KAKENHI-PROJECT-26461360
  • [Presentation] DulaglutideがPerilipin 2過剰発現による“脂肪心筋”に与える影響2016

    • Author(s)
      鈴木 仁弥, 佐藤 さつき, 中屋隆裕, 山田実夏, 市川麻衣, 山本勝司, 今川美智子, 藤井美紀, 銭丸康夫, 生山祥一郎, 弘瀬 雅教, 高橋貞夫, 石塚 全, 此下忠志
    • Organizer
      第59回日本糖尿病学会年次学術集
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-26461360
  • [Presentation] DulaglutideがPerilipin2過剰発現マウスの“脂肪心筋”に与える効果2016

    • Author(s)
      鈴木 仁弥, 佐藤 さつき, 中屋隆裕, 山田実夏, 市川麻衣, 山本勝司, 今川美智子, 藤井美紀, 銭丸康夫, 生山祥一郎, 弘瀬 雅教, 高橋貞夫, 此下忠志, 石塚 全
    • Organizer
      第48回 日本動脈硬化学会 総会・学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2016-07-14
    • Data Source
      KAKENHI-PROJECT-26461360
  • [Presentation] Heat shock factor 1 (Hsf1) plays a key role in AApoAII cardiac amyloidosis in mice2012

    • Author(s)
      Qian J, Hirose M, Zhang B, Wang Y, Tian G, Luo H, Liu Y, Fu X, Ge F, Sawashita J, Mori M, Fujimoto M, Nakai A, Higuchi K
    • Place of Presentation
      Groningen, The Netherlands
    • Data Source
      KAKENHI-PROJECT-23390093
  • [Presentation] Heat shock transcription factor 1 improves amyloid deposition-induced cardiac remodeling in a mouse model of senile cardiac amyloidosis2012

    • Author(s)
      Hirose M, Qian J, Shimojo H, Kashihara T, Hongo M, Yamada M, Higuchi K
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市
    • Data Source
      KAKENHI-PROJECT-23390093
  • [Presentation] Roles of heat shock transcription factor 1 gene (Hsf1) expressions in cardiac remodeling in a mouse model of senile cardiac amyloidosis2011

    • Author(s)
      Hirose M, Qian J, Shimojo H, Toshihide Kashihara T, Hongo M, Yamada M, Higuchi K
    • Organizer
      European Society of Cardiology Congress 2011
    • Place of Presentation
      Paris, France
    • Data Source
      KAKENHI-PROJECT-23390093
  • [Presentation] Nicorandil inhibits Gaq-induced chronic heart failure in transgenic mice2011

    • Author(s)
      Hirose M, Takeishi Y, Shimojo H, Kashihara T, Nakada T, Mende U, Hongo M, and Yamada M
    • Organizer
      American Heart Association BCVS 2011
    • Place of Presentation
      アメリカ(ニューオリンズ)
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] Olmesartan inhibits atrial remodeling in a mouse model of chronic heart failure2011

    • Author(s)
      弘瀬雅教, 竹石恭知, 下条久志, 柏原俊英, 中田勉, 中山貢一, 山田充彦
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] 心臓への老化アミロイド沈着と熱ストレス反応 : HSF1 ノックアウトマウスを用いた解析2011

    • Author(s)
      樋口 京一, 銭 金澤, 弘瀬 雅教, 張 蓓茹, 王 耀勇, 付 笑影, 澤下 仁子, 森 政之, 中井 彰
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-04-28
    • Data Source
      KAKENHI-PROJECT-23390093
  • [Presentation] Nicorandil inhibits G alpha q-induced chronic heart failure in transgenic mice2011

    • Author(s)
      弘瀬雅教, 竹石恭知, 柏原俊英, 中田勉, 山田充彦
    • Organizer
      第75回日本循環器学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] ニコランジルの慢性投与は、Gq-蛋白遺伝子改変マウスにおいて心不全誘発心室性不整脈の発生を抑制する2010

    • Author(s)
      弘瀬雅教
    • Organizer
      第61回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] Olmesartan inhibits G protein αq-induced atrial remodeling in transgenic mice.2010

    • Author(s)
      弘瀬雅教
    • Organizer
      83th American Heart Association Scientific Sessions 2010
    • Place of Presentation
      アメリカ(シカゴ)
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] ニコランジルの慢性投与は、Gq-蛋白遺伝子改変マウスにおいて心不全誘発心室性不整脈の発生を抑制する。2010

    • Author(s)
      弘瀬雅教
    • Organizer
      第61回日本薬理学会北部会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-10
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] Olmesartan inhibits G proteinαq-induced atrial remodeling in transgenic mice2010

    • Author(s)
      Hirose M, Takeishi Y, Shimojo H, Kashihara T, Nakada T, Mende U, Hongo M, and Yamada M
    • Organizer
      83th American Heart Association Scientific Sessions 2010
    • Place of Presentation
      アメリカ(シカゴ)
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] Activation of TRPC channels participates in the induction of ventricular arrhythmias in a mouse model of congestive heart failure.2009

    • Author(s)
      弘瀬雅教
    • Organizer
      Heart Failure 2009 and The Annual Congress of ISHR European section
    • Place of Presentation
      フランス(ニース)
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] Nicorandil Inhibits Ventricular Remodeling and Arrhythmias in a Mouse Model of Chronic Heart Failure2009

    • Author(s)
      Hirose M, Takeishi Y, Shimojo H, Nishio A, Nakada T, Kubota I, Mende U, Hongo M, Matsumoto K, and Yamada M
    • Organizer
      82th American Heart Association Scientific Sessions
    • Place of Presentation
      アメリカ(オーランド)
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] Activation of TRPC channels participates in the induction of ventricular arrhythmias in a mouse model of congestive heart failure2009

    • Author(s)
      Hirose M, Takeishi Y, Niizeki T, Horiuchi-Hirose M, Nakada T, Kubota M, Ulrike M, Yamada M
    • Organizer
      Heart Failure 2009 and The Annual Congress of ISHR European section
    • Place of Presentation
      フランス(ニース)
    • Data Source
      KAKENHI-PROJECT-21590276
  • [Presentation] SGLT1 participates in cardiac remodeling in pressure-overload-induced cardiomyopathy

    • Author(s)
      Masamichi Hirose, Naoko Matsushita, Atsushi Sanbe, Sayuri Matsuda, Risa Metoki, Yoshihiro Morino, Hermann Koepsell, Eiichi Taira
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Data Source
      KAKENHI-PROJECT-24590326
  • 1.  SUZUKI Jinya (20293417)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 2.  TAKAHASHI Sadao (50303376)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 3.  NAKADA Tsutomu (70452141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 4.  TAKEISHI Yasuchika (40272067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 5.  KOIZUMI Tsutomu (40126579)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  HIGUCHI Keiichi (20173156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 7.  MORI Masayuki (60273190)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 8.  SAWASHITA Jinko (40359732)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 9.  KAMETANI Fuyuki (70186013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KAKUTA Sigeru (80345032)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  SANBE Atsushi (30425706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  NAKANE Tokio (40155776)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  CHIBA Shigetoshi (30004659)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  古川 安之 (10111791)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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