NOBUHIRO Miyamura 宮村信博

Researcher Number	40274716
External Links
Affiliation (based on the past Project Information) *help	2010: 熊本大学, 大学院・生命科学研究部, 准教授 2009: 熊本大学, 医学部・付属病院, 講師 2002 – 2009: Kumamoto University, University Hospital, Assistant, 医学部附属病院, 講師 2008: Kumamoto University, 医学部・附属病院, 講師 2008: 熊本大学, 医学部付属病院, 講師 … More 2005: Kumamoto University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学薬学研究部, 講師 1999 – 2001: 熊本大学, 医学部・附属病院, 助手 1998: 熊本大学, 医学部附属病院, 助手 1997: KUMAMOTO UNIVERSITY HOSPITAL,RESEARCH ASSOCIATE, 医学部・附属病院, 助手 1997: 熊本大学, 医学部付属病院, 助手 1996: 熊本大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Metabolomics / Metabolomics Except Principal Investigator Metabolomics / Metabolomics / Biomedical engineering/Biological material science / Molecular biology / 内分泌・代謝学
Keywords	Principal Investigator 糖尿病 / GLUT2 / 膵β細胞 / proteome / regulation of gene expression / bio-molecule / signal transduction / diabetes mellitus / プロテオミクス / プロモーター解析 … More / TCCCTCCC配列 / DNAアフィニティーカラム / 転写因子 / インスリン受容体 / 肝細胞 / プロテオーム / 発現制御 / 生体分子 / シグナル伝達 / IP3 RECEPTOR / VDCC / K±ATP CHANNEL / PHOSPHOLIPASE C / GLUCOKINASE / NON-ISLETS CELL / ブドウ糖認識機構 / インスリン分泌調節遺伝子 / インスリン分泌応答機構 / IP3受容体 / 電位依存性Ca^<2+>チャネル / K^+ATP channel / フォスフォリパーゼC / グルコキナーゼ / 非膵島細胞 / インクレチン … More Except Principal Investigator 糖尿病 / IRS-1 / A3 element / 活性酸素 / ミトコンドリア / 酸化ストレス / protein kinase C / MnSOD / PGC-1α / AMPK / インスリン分泌 / 膵β細胞 / Mitochondria / Oxidative stress / Diabetic complications / E box / EBP / C / プロモーター / Electrophoretic mobility shift assay (EMSA) / trans acting factor / Insulin gene promoter / 転写因子 / 糖尿病合併症 / インスリン抵抗性 / 人工膵島 / CaM kinase II / insulin secretion / pancreatic beta cell / CaMキナーゼII / multivariate analysis / haemoglobin A1C / blood glucose measurement / non-invasive measuring system / 多変量解析 / ヘモグロビンA_<1c> / 血糖計測 / 非侵襲計測システム / Mitochondria biogenesis / Diabetes Mellitus / ミトコンドリアバイオジェネシス / strict glucose regulation / insulin infusion pump / artificial endocrine pancreas / needle-type glucose sensor / 過酸化水素電極 / センサ出力 / 血糖連続計測システム / ブドウ糖センサ / ポリイミド / 携帯型人工膵島 / 血糖制御 / インスリンポンプ / 針型ブドウ糖センサ / INHIBITORY PROTEIN / PROMOTER ANALYSIS / KNOCKOUT MOUSE / INSULIN SECRETION / CALMODULIN / CALCIUM / PANCREATIC BETA CELLS / Cre recombinase / 阻害蛋白CaMKIIN / プロモーター解析 / ノックアウトマウス / カルモデュリン / カルシウム / NUCLEAR FACTOR κB / CYCLOOXYGENASE-2 / REACTIVE OXYGENSPECIES / OXIDATIVE STRESS / MITOCHONDRIA / GLOMERULAR HYPERFILTRATION / DIABETIC NEPHROPATHY / DIABETS NELLITUS / プロスタグランジンE_2 / NFκB / シクロオキシゲナーゼ2 / 糸球体過剰濾過 / 糖尿病性腎症 / Manganese superoxide dismutase / 8-hydroxydeoxyguanosine / 血管合併症 / トランスジェニックマウス / マンガネーゼスーパーオキサイドジスムターゼ / 8-ハイドロキシデオキシグアノシン / 糖尿病性合併症 / diabetes mellitus / obesity / insulin resistance / 肥満 / Pancreatic and duodenal homeobox gene-1(PDX-1) / インスリン遺伝子 / PKCζ / atipical PKC / PDX-1 / INSULIN SENSITIVITY / BRADYKININ / EXERCISE / DIABETES MELLITUS / 運動療法 / インスリン感受性 / ブラジキニン / 運動 / gene / promoter / insulin / 遺伝子 / インスリン / Pancreatic and duodenal homeobox gene-1 (PDX-1) / TAAT配列 / CAT assay / EMSA / IPF1 / インスリン遺伝子プロモーター / 糖尿病大血管合併症 / エネルギー・糖代謝異常 / メタボリックシンドローム / MnSODA / 糖代謝異常 / エネルギー / cPLA2 / 動脈硬化 / COX-2 / PPARγ / マクロファージ / 脂肪細胞 / cPLA_2 / 超速効型インスリン / 超速效型インスリン / 皮下注入アルゴリズム / 人工臓器工学 Less

Effect of cPLA_2 inhibition on the prevention of diabetic macrovascular complication
- Principal Investigator
  
  MATSUMURA Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Impact of mitochondrial reactive oxygen species in the pathogenesis of diabetic nephropathy
- Principal Investigator
  
  NISHIKAWA Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Development of closed-loop subcutaneous insulin infusion algorithm using rapid-acting insulin analog
- Principal Investigator
  
  SHIMODA Seiya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kumamoto University
Effect of cPLA_2 inhibition on improvement of glucose tolerance through PPARγ activation
- Principal Investigator
  
  MATSUMURA Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
The inhibition of pancreatic b-cell deficiency and regenerationof β -cells by incretin signalsPrincipal Investigator
- Principal Investigator
  
  MIYAMURA Nobuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Development of near-infrared measuring system for blood glucose and haemoglobin A1c
- Principal Investigator
  
  NISHIDA Kenro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kumamoto University
Proteomics analysis for the novel liver specific transcription factors and clarification of their control signalsPrincipal Investigator
- Principal Investigator
  
  MIYAMURA Nobuhiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KUMAMOTO UNIVERSITY
Regulation of pancreatic・cell function by Ca2+/calmodulin-dependent protein kinase II delta.-Analysis using CaM-KIIN, noble inhibitory protein, and constitutive active CaM kinase II-
- Principal Investigator
  
  TSURUZOE Kaku
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KUMAMOTO UNIVERSITY
DEVELOPMENT OF A HIGHLY RESPONSIVE NEEDLE-TYPE GLUCOSE SENSOR USING POLYIMIDE FOR A WEARABLE ARTIFICIAL ENDOCRINE PANCREAS
- Principal Investigator
  
  SAKAKIDA Michiharu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  KUMAMOTO UNIVERSITY
Activation of AMPK reduces hyperglycemia-induced mitochondrial ROS production and promotion of mitochondrial biogenesis.
- Principal Investigator
  
  NISHIKAWA Takeshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
FUNCTIONAL ANALYSIS OF CA/CALMODULIN-DEPENDENT PROTEIN KINASE II IN PANCREATIC BETS-CELLS WITH CONDITIONAL KNOCKOUT MICE.
- Principal Investigator
  
  MATSUMOTO Kazuya
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KUMAMOTO UNIVERSITY
REACTIVE OXYGEN SPECIES FROM MITOCHONDRIA INDUCE CYCLOOXYGENASE-2 GENE EXPRESSION IN HUMAN MESANGIAL CELLS : POTENTIAL ROLE IN DIABETIC NEPHROPATHY
- Principal Investigator
  
  NISHIKAWA Takeshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KUMAMOTO UNIVERSITY
The role of mitochondria-derived reactive oxygen species in the pathogenesis of diabetic complications
- Principal Investigator
  
  TOYONAGA Tetsushi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Molecular mechanisms of insulin resistance in obesity-induced IRS-1 heterozygous knockout mice.
- Principal Investigator
  
  ARAKI Eiichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Analysis of mechanism in insufficiency of insulin secretion and transcription factors by glucotoxicity.
- Principal Investigator
  
  SHIROTANI Tetsuya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KUMAMOTO UNIVERSITY
Reconstruction of pancreatic beta cell in non-islet cell -Analysis of signal transduction in first phase of insulin secretionPrincipal Investigator
- Principal Investigator
  
  MIYAMURA Nobuhiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KUMAMOTO UNIVERSITY
Study of mechanism of potentiation of insulin sensitivity during exercise-bradykinin induced glucose uptake in muscle
- Principal Investigator
  
  KISHIKAWA Hideki
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  KUMAMOTO UNIVERSITY MEDICAL SCHOOL
Analysis of Mechanizm of Glucose Responsive Human Insulin Gene Expression.
- Principal Investigator
  
  SHIROTANI Tetsuya
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  KUMAMOTO UNIVERSITY
Analysis of the Mechanisms of Cell and Tissue Specific Expression of the Insulin Receptor Substrate, IRS-1 Gene.
- Principal Investigator
  
  ARAKI Eiichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  KUMAMOTO UNIVERSITY

All 2010 2009 2006 2005 2004

All Journal Article Presentation

[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010
- Author(s)
  Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice.2010
- Author(s)
  Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E
- Journal Title
  
  Arterioscler Thromb Vasc Biol 30
  
  Pages: 1598-1605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591065
[Journal Article] Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice2010
- Author(s)
  Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 30 Pages: 1598-1605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] A case of slowly progressive type 1 diabetes with unstable glycemic control caused by unusual insulin antibody and successfully treated with steroid therapy.2006
- Author(s)
  Matsuyoshi, A., Shimoda, S., Tsuruzoe, K., Taketa, K., Chirioka, T., Sakamoto, F., Sakakida, M., Miyamura, N., Araki, E.
- Journal Title
  
  Diabet Res Clin Pract. 72
  
  Pages: 238-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590942
[Journal Article] down-regulates the insulin receptor expression in HepG2 cells.2005
- Author(s)
  Nakamaru K, Matsumoto K, Taguchi T, Suefuji M, Murata Y, Igata M Kawashima J, Kondo T, Motoshima H, Tsuruzoe K, Miyamura N, Araki E: AICAR, an activator ofAMP-activated protein kinase
- Journal Title
  
  Biochem Biophys Res Commun 328
  
  Pages: 449-454
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590941
[Journal Article] 感音性難聴を伴うBartter症候群の1例-barttin遺伝子異常による新しい病型2004
- Author(s)
  宮村信博, 松本和也, 他
- Journal Title
  
  ホルモンと臨床 52
  
  Pages: 152-158
- NAID
  10013547563
- Data Source
  KAKENHI-PROJECT-15590949
[Presentation] 熊本県における高齢者の腎機能障害の現状2010
- Author(s)
  西川武志, 山城武司, 久木留大介, 吉永智昭, 本島寛之, 松村剛, 宮村信博, 荒木栄一
- Organizer
  日本老年医学会第20回九州地方会
- Place of Presentation
  熊本大学医学部医学教育図書棟
- Year and Date
  2010-03-13
- Data Source
  KAKENHI-PROJECT-20591065
[Presentation] 短期血糖コントロール指標としての血中可溶性インスリン受容体αサブユニットの有用性2010
- Author(s)
  本島寛之, 湯浅智之, 西川武志, 下田誠也, 近藤龍也, 河島淳司, 松村剛, 後藤理英子, 大久保美那, 前田貴子, 竹田佳代, 山城武司, 川崎修二, 堤厚之, 石井規夫, 久木留大介, 古川昇, 水流添覚, 宮村信博, 蛯名洋介, 荒木栄一
- Organizer
  第53回日本糖尿病学会総会
- Place of Presentation
  ホテルグランヴィア岡山・岡山コンベンションセンター・その他,岡山
- Data Source
  KAKENHI-PROJECT-21591144
[Presentation] 血中インスリン受容体αサブユニット量は血糖コントロール指標となりえるか?2009
- Author(s)
  本島寛之, 西川武志, 湯浅智之, 河島淳司, 後藤理英子, 小野薫, 花谷聡子, 木下博之, 川崎修二, 堤厚之, 児島協, 松村剛, 近藤龍也, 宮村信博, 蛯名洋介, 荒木栄一
- Organizer
  第52回日本糖尿病学会総会
- Place of Presentation
  大阪国際会議場,大阪
- Data Source
  KAKENHI-PROJECT-21591144

1. ARAKI Eiichi (10253733)

# of Collaborated Projects: 13 results

# of Collaborated Products: 5 results
2. NISHIKAWA Takeshi (70336212)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. TOYONAGA Tetsushi (60295128)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. TAKESHI Matsumura (20398192)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
5. SHIROTANI Tetsuya (30274715)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. KENRO Nishida (50336244)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. SHIMODA Seiya (60398203)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KISHIKAWA Hideki (30161441)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. MOTOSHIMA Hiroyuki (40398201)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. KONDO Tatsuya (70398204)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
11. SASAHARA Takayuki (20304991)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SAKAKIDA Michiharu (50170577)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. MATSUMOTO Kazuya (80346999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. FURUKAWA Noboru (90335795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TSURUZOE Kaku (50398202)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 七里元亮 (00028515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田口哲也 (30398200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NOBUHIRO Miyamura 宮村 信博

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The inhibition of pancreatic b-cell deficiency and regenerationof β -cells by incretin signalsPrincipal Investigator

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Proteomics analysis for the novel liver specific transcription factors and clarification of their control signalsPrincipal Investigator

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NOBUHIRO Miyamura 宮村信博