Kawai Makoto 川井真

… Alternative Names

川井眞カワイマコト

KAWAI Makoto 川井真

川井真カワイマコト

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Researcher Number	40277025
Other IDs
External Links
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2004 – 2009: 東京慈恵会医科大学, 医学部, 講師 2003: 東京慈恵会医科大学, 医学部, 助手 2000 – 2001: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Neurophysiology and muscle physiology
Keywords	Principal Investigator H交換系 / 細胞膜Na / α受容体刺激 / フェニレフリン / α・β受容体刺激 / PDE阻害 / c-AMP濃度 / 細胞内水素イオン濃度 / カルシウム感受性 / 細胞内カルシウムイオン濃度 / 単離心筋細胞 / ラット … More Except Principal Investigator … More Ca^<2+> / 筋小胞体Caポンプ / カルシウム / 心筋 / Ca^<2+> transients / cardiac muscle / mouse / saponin / skinned preparation / sarcolipin / sarcoplasmic reticulum / 細胞内Ca^<2+> / ウエスタンブロッティン / Ca^<2+>トランジェント / マウス / サポニン / スキンド標本 / サルコリピン / 筋小胞体 / SERCA / Acidosis / Diastolic dysfunction / Intracellular calcium concentration / Mouse heart / 心不全 / アンジオテンシンII / 細胞内カルシウム濃度 / アシドーシス / 拡張障害 / 細胞内Ca濃度 / マウス心筋 / 遺伝子改変 / リン酸化調節 / 筋小胞体機能 / 細胞内Ca動態 / 心臓病態学 / KN-93 / アンギオテンシン / α受容体 / 生理活性 / ETB受容体 / ラット / プロテインキナーゼ / ETA受容体 / パッチクランプ法 / プロテインキナーゼC / CaMKII / シグナル伝達 / カルシウム電流 / エンドセリン Less

Role of selective modulation of sarcoplasmic reticulum function on cardiac contraction during ischemia.
- Principal Investigator
  
  HONGO Kenichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jikei University School of Medicine
Coupling of protein kinase C and Ca/calmodulin dependent protein kinase II in cardiac muscle
- Principal Investigator
  
  KOMUKAI Kimiaki
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jikei University School of Medicine
Molecular mechanisms of Ca^<2+> uptake by sarcolipin in cardiac sarcoplasmic reticulum.
- Principal Investigator
  
  KURIHARA Satoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Jikei University School of Medicine
Mechanism of diastolic dysfunction in pressure-overloaded mouse heart
- Principal Investigator
  
  HONGO Kenichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  The Jikei University School of Medicine
モデル動物を用いた不全心筋の収縮及び細胞内カルシウム動態に関する研究Principal Investigator
- Principal Investigator
  
  川井真
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Jikei University School of Medicine

All 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Role of Ca2+/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca2+ current during endothelin-1 stimulation.2010
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Journal Title
  
  Am J Physiol Heart Circ Physiol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] ACE阻害薬と利尿薬併用の意義2010
- Author(s)
  川井真, 他
- Journal Title
  
  Modern Physician 30
  
  Pages: 412-6
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca2+ leak in mouse heart.2009
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Hoshina T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S
- Journal Title
  
  Biochem Biophys Res Commun 390(1)
  
  Pages: 87-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats.2009
- Author(s)
  Kawai M, et al
- Journal Title
  
  Hypertension Research 32
  
  Pages: 604-10
- NAID
  10025164290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy2009
- Author(s)
  Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I, Mochizuki S, Yoshimura M.
- Journal Title
  
  in renovascular hypertensive rats. Hypertens Res 32
  
  Pages: 604-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats2009
- Author(s)
  Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I Mochizuki S. Yoshimura M.
- Journal Title
  
  Hypertension Res 32
  
  Pages: 604-10
- NAID
  10025164290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increase Ca(2+) leak in mouse heart.2009
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Hosh T, Kusakari Y, Komukai K, Sasaki H, Hongo K, Kurihara S.
- Journal Title
  
  Biochem Biophys Res Commun 390
  
  Pages: 87-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] 神経体液因子からわかること2009
- Author(s)
  川井真, 他
- Journal Title
  
  Medicina 46
  
  Pages: 1238-41
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats.2009
- Author(s)
  Kawai M
- Journal Title
  
  Hypertens Res 32
  
  Pages: 604-610
- NAID
  10025164290
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy2009
- Author(s)
  Kawai M, Hongo K, Komukai K, Morimoto S, Nagai M, Seki S, Taniguchi I, Mochizuki S, Yoshimura M
- Journal Title
  
  in renovascular hypertensive rats. Hypertens Res 32(7)
  
  Pages: 604-610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Inhibition of the renin-angiotensin system prevents re-hospitalization of heart failure patients with preserved ejection fraction.2008
- Author(s)
  Komukai K, Yagi H, Ogawa T, Date T, Morimoto S, Kawai M, Hongo K, Taniguchi I, Yoshimura M
- Journal Title
  
  Circ J 72(12)
  
  Pages: 2004-2008
- NAID
  110006987355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure.2008
- Author(s)
  Komukai K, Ogawa T, Yagi H, Date T, Sakamoto H, Kanzaki Y, Shibayama K, Hashimoto K, Inada K, Minai K, Ogawa K, Kosuga T, Kawai M, Hongo K, Taniguchi I, Yoshimura M
- Journal Title
  
  Circ J 72(7)
  
  Pages: 1152-1157
- NAID
  110006792071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] Inhibition of the renin-angiotensin system prevents re-hospitalization in heart failure patients with preserved ejection fraction2008
- Author(s)
  Komukai K, Yagi H, Ogawa T, Date T, Morimoto S, Kawai M, Hongo K, Taniguchi I, Yoshimura M.
- Journal Title
  
  Circ J 72
  
  Pages: 2004-8
- NAID
  110006987355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Renal insufficiency is related to painless myocardial infarction.2007
- Author(s)
  Komukai K, Ogawa T, Yagi H, Date T, Suzuki K, Sakamoto H, Miyazaki H, Takatsuka H, Shibayama K, Ogawa K, Kanzaki Y, Kosuga T, Kawai M, Hongo K, Yoshida S, Taniguchi I, Mochizuki S
- Journal Title
  
  Circ J 71(9)
  
  Pages: 1366-1369
- NAID
  110006399679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] 交感神経受容体(カテコールアミン受容体)からのシグナル伝達の変化2007
- Author(s)
  川井真
- Journal Title
  
  日本臨牀 65
  
  Pages: 262-266
- Data Source
  KAKENHI-PROJECT-19590833
[Journal Article] 交感神経受容体(カテコールアミン受容体)からのシグナル伝達の変化2007
- Author(s)
  川井, ら
- Journal Title
  
  日本臨床 65(Suppl4)
  
  Pages: 262-266
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Use of the Ca-shortening curve to estimate the myofilament responsiveness to Ca2+ in tetanized rat ventricular myocytes.2006
- Author(s)
  Kusakari Y, Hongo K, Kawai M, Konishi M, Kurihara S.
- Journal Title
  
  J Physiol Sci 56
  
  Pages: 219-226
- NAID
  10020331576
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] ACE阻害薬による糖尿病発症予防効果(総説)2006
- Author(s)
  川井真ら
- Journal Title
  
  呼吸と循環 54・4
  
  Pages: 355-63
- Data Source
  KAKENHI-PROJECT-18590789
[Journal Article] Intracellular mechanism of the negative inotropic effect induced by alpha1-adrenoceptor stimulation in mouse myocardium.2006
- Author(s)
  Hirano S, Kusakari Y, O-Uchi J, Morimoto S, Kawai M, Hongo K, Kurihara S.
- Journal Title
  
  J Physiol Sci 56
  
  Pages: 297-304
- NAID
  130004466859
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Factors modulating the effect of endothelin-1 on L-type Ca current.2010
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
- Organizer
  第73回日本循環器学会学術集会
- Place of Presentation
  京都
- Year and Date
  2010-03-07
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Endothelin-1 Increases L-type Ca Current of Rat Ventricular Myocytes via an Activation of Protein Kinase C and Ca/calmodulin Dependent Protein Kinase II.2009
- Author(s)
  Komukai K, O-Uchi J, Hongo K, Kawai K, Morimoto S, Yoshimura M, Kurihara S
- Organizer
  AHA Scientific Sessions
- Place of Presentation
  Orlando USA
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Renin-angiotensin system plays an important role in the pathogenesis of DCM in mouse.2009
- Author(s)
  Hongo K, Morimoto S, O-Uchi J, Kusakari Y, Komukai K, Kawai M, Yoshimura M, Morimoto S, Ohtsuki I, Takeda N, Kurihara S
- Organizer
  XXXVIth International Congress of Physiological Sciences
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] β-adrenoceptor stimulation increased Ca leak from sarcoplasmic reticulum without dissociation of FKBP12. 6 under physiological condition.2009
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Komukai K, Sasaki H, Yoshimura M, Hongo K, Kurihara S
- Organizer
  XXXVIth International Congress of Physiological Sciences
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Endothelin-1 increases L-type Ca current of rat ventricular myocytes via an activation of protein kinase C and Ca/calmodulin dependt protein kinase II.2009
- Author(s)
  Komukai K, O-Uchi J, Hongo K, Kawai M, Morimoto S, Yoshimura M, Kurihara S.
- Organizer
  American Heart Association Scientific Session 2009
- Place of Presentation
  Orlando, Florida
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Endothelin-1 potentiates L-type Ca current by activating CaMKII in rat ventricular myocytes.2009
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
- Organizer
  The 36th Congress of the International Union of Physiological Sciences.
- Year and Date
  2009-07-28
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] β-adrenoceptor stimulation accelerates Ca2+ turnover through PKA-dependent phosphorylation in saponin-treated mouse myocardium.2008
- Author(s)
  Morimoto S, O-Uchi J, Kawai M, Komukai K, Hongo K, Sasaki H, Kurihara S
- Organizer
  第84回日本生理学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin dependent protein kinase II in rat ventricular myocytes2008
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Organizer
  日本循環器学会学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin-dependent protein kinase II in rat ventricular myocytes.2008
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] Endothelin-1 increases L-type Ca current via an activation of Ca/calmodulin- dependent protein kinase II in rat ventricular myocytes2008
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Yoshimura M, Kurihara S.
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Decreased Ca2+ sensitivity of the myofilament is critical for the development of cardiac dysfunction in mouse model of dilated cardiomyopathy.2008
- Author(s)
  Hongo K, Morimoto S, Komukai K, Kawai M, O-Uchi J, Yoshimura M, Kurihara S
- Organizer
  第72回日本循環器学会学術集会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19590833
[Presentation] The novel angiotensin receptor blocker,telmisartan prevents myocardial hypertrophy and fibrosis in renovascular hypertensive(Goldblatt)rat2007
- Author(s)
  Kawai, et. al.
- Organizer
  The 24th Annual Meeting of ISHR Japanese Section
- Place of Presentation
  Ferrara,Italy
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590789
[Presentation] Effect of endothelin-1 on L-type Ca current in rat ventricular myocytes.2007
- Author(s)
  Komukai K, O-Uchi J, Morimoto S, Kawai M, Hongo K, Kurihara S.
- Organizer
  第11回日本心不全学会学術集会
- Place of Presentation
  浦安
- Data Source
  KAKENHI-PROJECT-18590789

1. HONGO Kenichi (00256447)

# of Collaborated Projects: 4 results

# of Collaborated Products: 24 results
2. KOMUKAI Kimiaki (60360145)

# of Collaborated Projects: 3 results

# of Collaborated Products: 22 results
3. OTSU Kinya (20294051)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. KUSAKARI Yoichiro (80338889)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KURIHARA Satoshi (90057026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kawai Makoto 川井 真

川井 眞 カワイ マコト

KAWAI Makoto 川井 真

川井 真 カワイ マコト

Research Projects

Research Products

Co-Researchers

Role of selective modulation of sarcoplasmic reticulum function on cardiac contraction during ischemia.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Coupling of protein kinase C and Ca/calmodulin dependent protein kinase II in cardiac muscle

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of Ca^<2+> uptake by sarcolipin in cardiac sarcoplasmic reticulum.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of diastolic dysfunction in pressure-overloaded mouse heart

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

モデル動物を用いた不全心筋の収縮及び細胞内カルシウム動態に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Role of Ca2+/calmodulin-dependent protein kinase II in the regulation of the cardiac L-type Ca2+ current during endothelin-1 stimulation.2010

Author(s)

Journal Title

Data Source

[Journal Article] ACE阻害薬と利尿薬併用の意義2010

Author(s)

Journal Title

Data Source

[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increases Ca2+ leak in mouse heart.2009

Author(s)

Journal Title

Data Source

[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy2009

Author(s)

Journal Title

Data Source

[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Protein kinase A-dependent phosphorylation of ryanodine receptors increase Ca(2+) leak in mouse heart.2009

Author(s)

Journal Title

Data Source

[Journal Article] 神経体液因子からわかること2009

Author(s)

Journal Title

Data Source

[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy, in renovascular hypertensive rats.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Telmisartan predominantly suppresses cardiac fibrosis, rather than hypertrophy2009

Author(s)

Journal Title

Data Source

Kawai Makoto 川井真

川井眞カワイマコト

KAWAI Makoto 川井真

川井真カワイマコト