Ishikawa Hideaki 石川秀明

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ISHIKAWA Hideaki 石川秀明

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Researcher Number	40294623
Other IDs
External Links
Affiliation (Current)	2025: 千里金蘭大学, 栄養学部, 教授 2025: 千里金蘭大学, 生活科学部, 教授
Affiliation (based on the past Project Information) *help	2012: 千里金蘭大学, 生活科学部, 教授 2010 – 2011: 山口大学, 大学院・医学系研究科, 准教授 2007 – 2008: Yamaguchi University, 大学院・医学系研究科, 准教授 2006: Yamaguchi University, Graduate School of Medicine・Bio-Signal Analysis, Associate Professor, 大学院医学系研究科, 助教授 2005: 山口大学, 大学院・医学系研究科, 助教授 2001 – 2004: Yamaguchi University, Graduate School of Medicine, Associate Professor, 大学院・医学研究科, 助教授 1997 – 2000: 山口大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Hematology / Hematology / Biological Sciences Except Principal Investigator Biological Sciences / Hematology / Hematology
Keywords	Principal Investigator IL-6 / CD45 / 骨髄腫 / Lyn / 2 / ERK1 / STAT3 / CD19 / Akt / PI 3-kinase … More / FGFR3 / 細胞増殖 / cell proliferation / myeloma / PI3-kinase / IL-6Rα / PLC / MAPK / PKM2 / 解糖系 / signal-transducing molecules / IL-6誘導遺伝子 / マイクロアレイ / 質量分析 / 刺激伝達分子 / raft / cell survival / IGF-I receptor / IL-G / サブトラクション / IGF-I / ラフト / 細胞生存 / IL-6受容体α / IGF-I受容体 / src family kinase / multiple myeloma / アポトーシス / STAT / src / Caイオン / src型PTK / 骨髄腫細胞 / SCID mice / signal transduction / SCIDマウス / 刺激伝達 / Fox01 / NF-kB / FoxO1 / 成長因子 / シグナル伝達 / チロシン・キナーゼ / 発がん / インターロイキン6 … More Except Principal Investigator 骨髄腫 / IL-6 / 骨髄腫細胞 / CD45 / CD19 / 未熟型骨髄腫細胞 / Pax-5 / 形質細胞分化 / 良性M蛋白血症 / Galectin-1 / CD45RA / lipid rafts / 脂質ラフト / immature myeloma cells / myeloma / STAT3 / STAT1 / SCIDマウス / MPC-1 / 表面抗原解析 / M蛋白血症 / signal transduction / CD45R0 / myeloma cells / CD-45 / シグナル伝達 / CD45RO / CD45 isoform / 細胞膜分子動態 / ラフト / フォスファターゼ / CD45アイソフォーム / differentiation inducing therapy / SCID mice / interleukin 6 / myeloma cell differentiation / MAPK / Lyn / 分化誘導療法 / 骨髄腫細胞分化 / SCID mouse / Myeloma cell / Transcription factor / Gene transfer / Methylation / Myeloma / 転写因子 / 遺伝子導入 / メチル化 / PPAR / NF-kB / DHEA / 遺伝子プロファイリング / MGUS / 未熟型形質細胞 / 未熟形質細胞 Less

The Role of the Lyn-PI 3-kinase signaling pathways and PKM2 in the myeloma cell proliferationPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Hideaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Senri Kinran University
  Yamaguchi University
Analysis of the CD45-Lyn-mediated signaling pathways in theIL-6-induced myeloma cell proliferationPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Hideaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
Analysis of the IL-6-mediated intracellular signaling molecules in myeloma cell growthPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Hideaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
The mechanism of translocation of CD45R0 to lipid rafts in IL-6-induced proliferation of human myeloma cells
- Principal Investigator
  
  KAWANO Michio, 津山尚宏
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
前癌病変BMGから骨髄腫への進展に関わるホルモンDHEAの動態とその機能解析
- Principal Investigator
  
  河野道生
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yamaguchi University
前癌病変良性M蛋白血症から骨髄腫への進展に関する分子疫学的研究
- Principal Investigator
  
  河野道生
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yamaguchi University
Regulatory mechanism of membrane coreceptors in the proliferation of human myeloma cells
- Principal Investigator
  
  KAWANO Michio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
Analysis of the signal transduction molecules and genes that regulate the proliferation of myeloma cellsPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Hideki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
IL-6による骨髄腫発がんにおける受容体型チロシン・キナーゼの役割Principal Investigator
- Principal Investigator
  
  石川秀明
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Yamaguchi University
骨髄腫の前癌病変BMGから骨髄腫への進展に関する研究
- Principal Investigator
  
  河野道生
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Yamaguchi University
骨髄腫を含めたM蛋白血症の進展と未熟形質細胞の動態との関連
- Principal Investigator
  
  KAWANO Michio
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Yamaguchi University
Functional analysis of the molecules modulating the proliferative signals of human myeloma cells by IL-6Principal Investigator
- Principal Investigator
  
  ISHIKAWA Hideaki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
Differentiation induction of human myeloma cells
- Principal Investigator
  
  KAWANO Michio M
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
Involvement of CD19 molecules in proliferation of human immature myeloma cells by interleukin-6Principal Investigator
- Principal Investigator
  
  ISHIKAWA Hideaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University
Oncogenesis of Human Myeloma and Altered Expression of Pax-5 gene
- Principal Investigator
  
  KAWANO Michio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Yamaguchi University

All 2013 2012 2011 2010 2008 2007 2006 2005 2004 2002

All Journal Article Presentation Book

[Book] 別冊日本臨牀　血液症候群III2013
- Author(s)
  石川秀明
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22591039
[Book] 別冊日本臨牀血液症候群III-その他の血液疾患を含めて-第2版2013
- Author(s)
  石川秀明
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22591039
[Book] 多発性骨髄腫治療マニュアル2012
- Author(s)
  石川秀明
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-22591039
[Book] Annual Review 2004 血液2004
- Author(s)
  石川秀明
- Total Pages
  8
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-14370305
[Journal Article] 骨髄腫細胞のシグナル伝達2012
- Author(s)
  石川秀明
- Journal Title
  
  医学のあゆみ
  
  Volume: Vol. 242, No. 13 Pages: 1027-1032
- URL
  http://www.ishiyaku.co.jp/
- Data Source
  KAKENHI-PROJECT-22591039
[Journal Article] A novel signaling pathway associated with Lyn,PI3-kinase and Akt supports the proliferation of myeloma cells2010
- Author(s)
  Mohd S. Iqbal, Naohiro Tsuyama , Masanori Obata and Hideaki Ishikawa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: Vol. 392, No. 3 Issue: 3 Pages: 415-420
- DOI
  10.1016/j.bbrc.2010.01.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591039
[Journal Article] 骨髄腫細胞の増殖機構2008
- Author(s)
  石川秀明、小幡雅則
- Journal Title
  
  血液・腫瘍科 57
  
  Pages: 148-150
- Data Source
  KAKENHI-PROJECT-19591115
[Journal Article] Mitogenic signals initiated via IL-6 receptor complexes in cooperation with other transmembrane molecules in myelomas2006
- Author(s)
  Hideaki Ishikawa
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology 46・2
  
  Pages: 55-66
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590999
[Journal Article] Mitogenic signals initiated via IL-6 receptor complexes in cooperation with other transmembrane molecules in myelomas2006
- Author(s)
  Hideaki Ishikawa
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology 46(2)
  
  Pages: 55-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590999
[Journal Article] Accelerated proliferation of myeloma cells by interleukin-6 co-operating with fibroblast growth factor receptor 3-mediated signals2005
- Author(s)
  Hideaki Ishikawa
- Journal Title
  
  Oncogene 24(41)
  
  Pages: 6328-6332
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590999
[Journal Article] Accelerated proliferation of myeloma cells by interleukin-6 co-operating with fibroblast growth factor receptor 3-mediated signals2005
- Author(s)
  Hideaki Ishikawa
- Journal Title
  
  Oncogene 24・41
  
  Pages: 6328-6332
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590999
[Journal Article] Requirement of src family kinase activity associated with CD45 for Myeloma cell proliferation by interleukin-62002
- Author(s)
  Ishikawa H
- Journal Title
  
  BLOOD 90
  
  Pages: 2172-2178
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370305
[Journal Article] Requirement of src family kinase activity associated with CD45 for Myeloma cell proliferation by interleukin-62002
- Author(s)
  Ishikawa H, et al.
- Journal Title
  
  Blood 99
  
  Pages: 2172-2178
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370305
[Presentation] IL-6-induced phosphorylation ofAkt and FoxO1 in human myeloma cell lines(IL-6 刺激後の骨髄腫細胞における Akt と FoxO1 のリン酸化)2011
- Author(s)
  石川秀明
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] 骨髄腫細胞におけるIL-6刺激後PI 3-kinase-Akt刺激伝達系標的分子Fox01のリン酸化2011
- Author(s)
  石川秀明
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] IL-6刺激後の骨髄腫細胞におけるAktとFox01の・リン酸化2011
- Author(s)
  石川秀明
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] IL-6-induced phosphorylation of FoxO1 as a target of the PI-3-kinase-Akt pathway in myeloma cells(骨髄腫細胞における IL-6 刺激後 PI3-kinase-Akt 刺激伝達系標的分子 FoxO1 のリン酸化)2011
- Author(s)
  石川秀明、小幡雅則
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] Lyn-PI 3-kinase-Akt刺激伝達系による骨髄腫細胞の増殖機構2010
- Author(s)
  石川秀明
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  兵庫県・神戸国際展示場
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] The Lyn,PI 3-kinase and Akt signaling pathway supports the proliferation of humanmyeloma cells(Lyn-PI3 kinase-Akt 刺激伝達系はヒト骨髄腫細胞の増殖を促進する)2010
- Author(s)
  石川秀明、Mohd S. Iqbal,、津山尚宏、小幡雅則
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] The Lyn, PI 3-kinase and Akt signaling pathway supports the proliferation of human myeloma cells2010
- Author(s)
  石川秀明
- Organizer
  第72回日本血液学会学術集会
- Place of Presentation
  神奈川県・パシフィコ横浜
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] Lyn-PI 3-kinase-Akt 刺激伝達系による骨髄腫細胞の増殖機構2010
- Author(s)
  石川秀明、Mohd S. Iqbal、津山尚宏、小幡雅則
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] The IL-6-mediated signaling pathway associated with Lyn,PI 3-kinase and Akt supports the proliferation of human myeloma cells2010
- Author(s)
  Hideaki Ishikawa, Mohd S. Iqbal, Naohiro Tsuyama and Masanori Obata
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  神戸
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] The IL-6-mediated signaling pathway associated with Lyn, PI 3-kinase and Akt supports the proliferation of human myeloma cells2010
- Author(s)
  Hideaki Ishikawa
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  兵庫県・神戸国際展示場
- Year and Date
  2010-08-24
- Data Source
  KAKENHI-PROJECT-22591039
[Presentation] The IL-6-inducedcell proliferation depends on thecellular context in myelomas2008
- Author(s)
  Hideaki Ishikawa
- Organizer
  第38回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19591115
[Presentation] The IL-6-induced cell proliferation depends on the cellular context in myelomas2008
- Author(s)
  Hideaki Ishikawa
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都市
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19591115
[Presentation] IL-6による骨髄腫細胞増殖刺激伝達系におけるLynの関与2007
- Author(s)
  石川秀明
- Organizer
  第30回日本分子生物学会年会・第80 回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591115
[Presentation] IL-6による骨髄腫細胞増殖刺激伝達系におけるLynの関与2007
- Author(s)
  石川秀明
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19591115

1. KAWANO Michio (40161343)

# of Collaborated Projects: 13 results

# of Collaborated Products: 0 results
2. TSUYAMA Naohiro (10335747)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. OBATA Masanori (80158831)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
4. 石田禎夫 (20305220)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. MIZUKAMI Yoichi (80274158)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. FUJII Ryuichi (30264401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ishikawa Hideaki 石川 秀明

ISHIKAWA Hideaki 石川 秀明

Research Projects

Research Products

Co-Researchers

The Role of the Lyn-PI 3-kinase signaling pathways and PKM2 in the myeloma cell proliferationPrincipal Investigator

Principal Investigator

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Analysis of the CD45-Lyn-mediated signaling pathways in theIL-6-induced myeloma cell proliferationPrincipal Investigator

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Analysis of the IL-6-mediated intracellular signaling molecules in myeloma cell growthPrincipal Investigator

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Analysis of the signal transduction molecules and genes that regulate the proliferation of myeloma cellsPrincipal Investigator

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IL-6による骨髄腫発がんにおける受容体型チロシン・キナーゼの役割Principal Investigator

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Functional analysis of the molecules modulating the proliferative signals of human myeloma cells by IL-6Principal Investigator

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Project Period (FY)

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Principal Investigator

Project Period (FY)

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Involvement of CD19 molecules in proliferation of human immature myeloma cells by interleukin-6Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Ishikawa Hideaki 石川秀明

ISHIKAWA Hideaki 石川秀明

[Book] 別冊日本臨牀　血液症候群III2013