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SAWAI Hirofumi  澤井 宏文

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… Alternative Names

澤井 宏文  サワイ ヒロフミ

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Researcher Number 40298823
Other IDs
Affiliation (based on the past Project Information) *help 2012 – 2015: 大阪歯科大学, 歯学部, 講師
2010 – 2011: 大阪歯科大学, 歯学部, 助教
2007 – 2008: Osaka Dental University, Dept. of Dentistry, Assistant Professor
2006: 大阪歯科大学, 歯学部, 助手
2001 – 2002: 大阪歯科大学, 歯学部, 助手
Review Section/Research Field
Principal Investigator
Pathobiological dentistry/Dental radiology / Hematology
Except Principal Investigator
Periodontal dentistry
Keywords
Principal Investigator
p38 MAPK / NSAID / ERK / RANKL / グルココルチコイド / メタボリックシンドローム / 歯周病 / aspirin / sodium salicylate / osteoclast … More / p38 / アスピリン / サリチル酸ナトリウム / p38MAPK / 破骨細胞 / 11β-HSD1 / コルチゾル / 11β-HSD1 / 歯学 / 肥満 / 慢性炎症 / コルチゾール / 11β-HSD1 / メタボリック症候群 / 慢性歯周炎 / 11β-HSD1 / 抗癌剤 / 分化誘導 / 中性スフィンゴミエリナーゼ / PKA / c-jun / アポトーシス / スフィンゴシン / PKC / セラミド … More
Except Principal Investigator
歯周病 / 動脈硬化 / 11β-HSD1 / 虚血性心疾患 / 動脈硬化症 / メタボリックシンドローム / 内科 / 歯学 / シグナル伝達 / メタボリック シンドローム Less
  • Research Projects

    (6 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (14 People)
  •  Application of 11beta-HSD1 inhibitors to the treatment of periodontal diseasePrincipal Investigator

    • Principal Investigator
      SAWAI Hirofumi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Osaka Dental University
  •  The role of 11β-HSD1, an intracellular glucocorticoid-activating enzyme, in periodontal diseasePrincipal Investigator

    • Principal Investigator
      SAWAI Hirofumi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Osaka Dental University
  •  The role of periodontal disease in formation of atherosclerotic lesion

    • Principal Investigator
      DOMAE Naochika
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Osaka Dental University
  •  Studies on the etiological relationship between periodontitis and life-style related diseases

    • Principal Investigator
      DOMAE Naochika
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Osaka Dental University
  •  Mechanism of osteoclast differentiation induced by sodium salicylatePrincipal Investigator

    • Principal Investigator
      SAWAI Hirofumi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathobiological dentistry/Dental radiology
    • Research Institution
      Osaka Dental University
  •  血液細胞の分化・アポトーシスにおけるスフィンゴ脂質の役割Principal Investigator

    • Principal Investigator
      澤井 宏文
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      Osaka Dental University

All 2016 2015 2014 2013 2011 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

  • [Journal Article] The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity2016

    • Author(s)
      Nakata T, Fujita A, Umeda M, Yoshida H, Inami K, Masuzaki H, Sawai H
    • Journal Title

      SpringerPlus

      Volume: 5 Issue: 1

    • DOI

      10.1186/s40064-016-1679-6

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Journal Article] Differential changes in sphingolipids between TNF-induced necroptosis and apoptosis in U937 cells and necroptosis-resistant sublines2015

    • Author(s)
      Sawai H, Ogiso H, Okazaki T
    • Journal Title

      Leukemia Research

      Volume: 39 Issue: 9 Pages: 964-970

    • DOI

      10.1016/j.leukres.2015.06.002

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Journal Article] An inhibitory role for caspase-3 at the late stage of RANKL-induced osteoclast differentiation in RAW264 cells and mouse bone marrow macrophages.2014

    • Author(s)
      Katao Y, Shishido M, Inami K, Matsumoto N, Sawai H.
    • Journal Title

      Cell Biology International

      Volume: 38 Issue: 6 Pages: 723-728

    • DOI

      10.1002/cbin.10263

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Journal Article] Characterization of TNF-induced caspase-independent necroptosis.2014

    • Author(s)
      Sawai H.
    • Journal Title

      Leukemia Research

      Volume: 38 Issue: 6 Pages: 706-713

    • DOI

      10.1016/j.leukres.2014.02.002

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Journal Article] Involvement of 11 β -HSD1 in metabolic syndrome and periodontal disease.2013

    • Author(s)
      Shiraishi M, Sawai H, Nagano Y, Ueda M,Umeda M.
    • Journal Title

      J Osaka Dent Univ

      Volume: 47 Pages: 7-10

    • NAID

      110009603273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592323
  • [Journal Article] Involvement of 11β-HSD1 in metabolic syndrome and periodontal disease2013

    • Author(s)
      Shiraishi M, Sawai H, Nagano Y, Ueda M, Umeda M.
    • Journal Title

      Journal of Osaka Dental University

      Volume: 47 Pages: 7-10

    • NAID

      110009603273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105
  • [Journal Article] Involvement of 11β-HSD1 in metabolic syndrome and periodontal disease2013

    • Author(s)
      Shiraishi M, Sawai H, Nagano Y, Ueda M, Umeda M.
    • Journal Title

      Journal of Osaka Dental University

      Volume: 47 Pages: 7-10

    • NAID

      110009603273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592323
  • [Journal Article] Facilitation of experimental tooth movement by NOC-18, a long-acting nitric oxide donor2013

    • Author(s)
      Mika Shishido、Hirofumi Sawai、Kaoru Inami、 Yuko Katao 、Naoyuki Matsumoto
    • Journal Title

      Orthodontic Waves

      Volume: 72 Issue: 2 Pages: 43-48

    • DOI

      10.1016/j.odw.2012.12.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105, KAKENHI-PROJECT-22592323, KAKENHI-PROJECT-25462941
  • [Journal Article] Involvement of 11β-HSD1 in metabolic syndrome and periodontal disease2013

    • Author(s)
      Masanori Shiraishi、Hirofumi Sawai、 Yutaka Nagano、Masatoshi Ueda、Makoto Umeda
    • Journal Title

      Journalof Osaka Dental University

      Volume: 47 Pages: 7-10

    • NAID

      110009603273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105
  • [Journal Article] Augmentation of RANKL-induced osteoclast differentiation by Z-VAD-fmk, a pan-caspase inhibitor.2013

    • Author(s)
      Katao Y, Sawai H, Shishido M, Omae A, Liao W, Inami K, Matsumoto N.
    • Journal Title

      J Osaka Dent Univ

      Volume: 47 Pages: 41-46

    • NAID

      110009603277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Journal Article] Involvement of 11β-HSD1 in metabolic syndrome and periodontal disease.2013

    • Author(s)
      Shiraishi M, Sawai H, Nagano Y, Ueda M, Umeda M.
    • Journal Title

      J Osaka Dent Univ

      Volume: 7-10 Pages: 7-10

    • NAID

      110009603273

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Journal Article] Differential effects of caspase inhibitors on TNF-induced necroptosis、Biochemical and Biophysical2013

    • Author(s)
      Hirofumi Sawai
    • Journal Title

      Research Communications

      Volume: 432 Issue: 3 Pages: 451-455

    • DOI

      10.1016/j.bbrc.2013.01.126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105, KAKENHI-PROJECT-22592323, KAKENHI-PROJECT-25462941
  • [Journal Article] Augmentation of RANKL-induced osteoclast differentiation by Z-VAD-fmk,a pan-caspase inhibitor.2013

    • Author(s)
      Katao Y, Sawai H, Shishido M, Omae A, Liao W, Inami K, Matsumoto N.
    • Journal Title

      J Osaka Dent Univ

      Volume: 47 Pages: 41-46

    • NAID

      110009603277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592323
  • [Journal Article] Augmentation of RANKL-induced osteoclast differentiationby Z-VAD-fmk, a pan-caspase inhibitor2013

    • Author(s)
      Yuko Katao 、 Hirofumi Sawai 、 Mika Shishido、Aki Omae、Wen Liao、Kaoru Inami、 Naoyuki Matsumoto
    • Journal Title

      Journal of Osaka Dental University

      Volume: 47 Pages: 41-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105
  • [Journal Article] Augmentation of RANKL-induced osteoclast differentiation by Z-VAD-fmk, a pan-caspase inhibitor2013

    • Author(s)
      Katao Y, Sawai H, Shishido M, Omae A, Liao W, Inami K, Matsumoto N.
    • Journal Title

      Journal of Osaka Dental University

      Volume: 47 Pages: 41-46

    • NAID

      110009603277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105
  • [Journal Article] Direct effects of estrogen on differentiation and apoptosis of osteoclasts2011

    • Author(s)
      Yuko Katao、Hirofumi Sawai、Kaoru Inami、 Naochika Domae、Naoyuki Matsumoto
    • Journal Title

      Orthodontic Waves

      Volume: 70 Issue: 1 Pages: 8-14

    • DOI

      10.1016/j.odw.2010.07.002

    • NAID

      130005024638

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105, KAKENHI-PROJECT-22592323
  • [Journal Article] Discrimination between primary necrosis and apoptosis by necrostatin-1 in Annexin V-positive/propidium iodide-negative cells 、 Biochemical and BiophysicalResearch2011

    • Author(s)
      Hirofumi Sawai 、 Naochika Domae
    • Journal Title

      Communications

      Volume: 411 Issue: 3 Pages: 569-573

    • DOI

      10.1016/j.bbrc.2011.06.186

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105, KAKENHI-PROJECT-22592323
  • [Journal Article] Effect of long acting nitric oxide donors on the differentiation of osteoclasts derived from mouse bone marrow macrophages2010

    • Author(s)
      Kaoru Inami、Hirofumi Sawai、Yuko Katao、 Mika Shishido、Yousuke Ujii、Misa Shimozuma、 Kensuke Nobata、Naochika Domae、Naoyuki Matsumoto
    • Journal Title

      Journal of Osaka Dental University

      Volume: 44 Pages: 133-138

    • NAID

      110007811662

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592105
  • [Journal Article] Effect of long acting nitric oxide donors on the differentiation of osteoclasts derived from mouse bone marrow macrophages.2010

    • Author(s)
      Inami K, Sawai H, Katao Y, Shishido M, Ujii Y, Shimozuma M, Nobata K, Domae N, Mastumoto N.
    • Journal Title

      J Osaka Dent Univ

      Volume: 44 Pages: 133-138

    • NAID

      110007811662

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22592323
  • [Journal Article] Differential roles for Bak in triton X-100- and deoxycholate- induced apoptosis2009

    • Author(s)
      SAWAI H, DOMAE N
    • Journal Title

      Biochem Biophys Res Commun 378

      Pages: 529-533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Journal Article] Induction of osteoclast differentiation by NOC-18, a long- acting nitric oxide donor2009

    • Author(s)
      INAMI K, SAWAI H, YAKUSHIJI K, DOMAE N, MASTUMOTO N
    • Journal Title

      Orthodont Waves 68

      Pages: 20-27

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Journal Article] Differential roles for Bak in triton X-100- and deoxycholate-induced apoptosis.2009

    • Author(s)
      Sawai H.
    • Journal Title

      Biochem Biophys Res Commun 378

      Pages: 529-533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Journal Article] Release of cytochrome c from mitochondria precedes Baxtranslocation/activation in Triton X-100-induced apoptosis2008

    • Author(s)
      SAWAI H.
    • Journal Title

      Leuk Res 32

      Pages: 445-453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Journal Article] Augmentation of TNF- induced osteoclast differentiation by inhibition of ERK and activation of p38 : Similar intracellular signaling between RANKL- and TNF-induced osteoclast differentiation2008

    • Author(s)
      INAMI K, SAWAI H, YAKUSHIJI K, KATAO Y, MASTUMOTO N, DOMAE N
    • Journal Title

      Orthodont Waves 67

      Pages: 150-156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Journal Article] Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis2008

    • Author(s)
      SAWAI H, DOMAE N.
    • Journal Title

      Leuk Res 32

      Pages: 445-453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Journal Article] Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis.2008

    • Author(s)
      Sawai H.
    • Journal Title

      Leuk Res 32

      Pages: 445-453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Journal Article] Augmentation of TNF-induced osteoclast differentiation by inhibition of ERIC and activation of p38 : Similar intracellular signaling between RANKL-and TNF-induced osteoclast differentiation

    • Author(s)
      Kaoru Inami, Hirofumi Sawai, Kentaro Yakushiji, Yuko Katao, Naoyuki Matsumoto, Naochika Domae
    • Journal Title

      Orthodontic Waves (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592078
  • [Presentation] 慢性歯周炎における細胞内グルココルチコイド活性化酵素11β-HSD1発現の増加2015

    • Author(s)
      藤田敦子、中田貴也、澤井宏文、居波薫、吉田博昭、益崎裕章、大久保直、梅田誠
    • Organizer
      第58回秋季日本歯周病学会学術大会
    • Place of Presentation
      アクトシティ浜松(浜松市)
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Presentation] 歯周炎モデルラットにおける11β-HSD1発現の比較・検討2015

    • Author(s)
      中田貴也、藤田敦子、澤井宏文、益崎裕章、大久保直、梅田誠
    • Organizer
      日本歯科保存学会2015年度秋季学術大会(第143回)
    • Place of Presentation
      文京シビックホール(東京)
    • Year and Date
      2015-11-12
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Presentation] 歯周病における細胞内グルココルチコイド活性化酵素11β-HSD1との関連.2014

    • Author(s)
      中田貴也,澤井宏文,益崎裕章,藤田敦子,白石真教,吉田博昭,大久保 直,梅田 誠.
    • Organizer
      日本歯周病学会2014秋季学術大会(第57回)
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2014-10-19
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Presentation] カスパーゼ-3阻害剤による破骨細胞分化の増強.2013

    • Author(s)
      宍戸美香,澤井宏文,居波 薫,片尾祐子,西浦亜紀,松本尚之.
    • Organizer
      第72回日本矯正歯科学会大会
    • Place of Presentation
      キッセイ文化ホール(長野県松本市)
    • Data Source
      KAKENHI-PROJECT-25462941
  • [Presentation] 長時間作用型NO供与体(NOC-18)による破骨 細胞分化誘導2008

    • Author(s)
      居波 薫,澤井宏文,藥師寺健太郎,堂前尚親,松本尚之
    • Organizer
      第67回日本矯正 歯科学会大会
    • Place of Presentation
      東京都
    • Year and Date
      2008-09-18
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Presentation] 破骨細胞分化におけるエストロゲンの役割2008

    • Author(s)
      片尾祐子,澤井宏文,居波 薫, 堂前尚親,松本尚之
    • Organizer
      第67回日本矯正歯科学会大会
    • Place of Presentation
      東京都
    • Year and Date
      2008-09-18
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Presentation] 一酸化窒素による破骨細胞分化誘導におけるMAPキナーゼの関与について2007

    • Author(s)
      居波 薫,澤井宏文,藥師寺健太郎, 片尾祐子,神原敏之,堂前尚親
    • Organizer
      第66回日本矯正歯科学会大会
    • Place of Presentation
      大阪府
    • Year and Date
      2007-09-20
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Presentation] アスピリンはMAPKを介してRANKLによるRAWの破骨細胞様細胞への分化を促進する2007

    • Author(s)
      薬師寺健太郎,澤井宏文,居波 薫, 神原正樹,堂前尚親
    • Organizer
      2007日本歯周病学会春季学術大会 (第50回)
    • Place of Presentation
      神奈川県
    • Year and Date
      2007-05-17
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Presentation] Involvement of signal pathway in osteoclast differentiation induced by TNF-alpha2007

    • Author(s)
      INAMI K, SAWAI H, YAKUSHIJI K, KAMBARA T, DOMAE N
    • Organizer
      83^<nd> Congress of the European Orthodontics Society
    • Place of Presentation
      Berlin
    • Year and Date
      2007-06-22
    • Data Source
      KAKENHI-PROJECT-19592398
  • [Presentation] Involvement of MAP kinases in osteoclast differentiation induced by nitric oxide2007

    • Author(s)
      Kaoru Inami, Hirofumi Sawai, Kentaro Yakushiji, Toshiyuki Kambara, Naochika Domae
    • Organizer
      The 66th Annual Meeting of the Japanese Orthodontic Society
    • Place of Presentation
      Osaka International Convention Center
    • Year and Date
      2007-09-19
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592078
  • [Presentation] Aspirin promotes RANKL induced RAW differentiation into osteoclasts via MAPK signaling2007

    • Author(s)
      Kentaro Yakushiji, Hirofumi Sawai, Kaoru Inami. Masaki Kambara, Naochika Domae
    • Organizer
      2007 Spring Meeting of the Japanese Society of Periodontology
    • Place of Presentation
      Yokosuka Arts Theatre
    • Year and Date
      2007-05-17
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592078
  • [Presentation] Effect of sodium salicylate on RANKL-induced osteoclast differentiation of RAW264 cells2006

    • Author(s)
      Kentaro Yakushiji, Hirofumi Sawai, Kaoru Inami. Masaki Kambara, Naochika Domae
    • Organizer
      The 24th Annual Meeting of the Japanese Society for Bone and Mineral Research
    • Place of Presentation
      Tokyo Fashion Town
    • Year and Date
      2006-07-06
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592078
  • [Presentation] Involvement of signal transduction pathways in osteoclast differentiation induced by TNF-α2006

    • Author(s)
      Kaoru Inami, Hirofumi Sawai, Kentaro Yakushiji, Toshiyuki Kambara, Naochika Domae, Tatsuo Kawamoto
    • Organizer
      The 65th Annual Meeting of the Japanese Orthodontic Society
    • Place of Presentation
      Sapporo Convention Center
    • Year and Date
      2006-09-13
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18592078
  • 1.  DOMAE Naochika (60115889)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 18 results
  • 2.  NAGANO Yutaka (80228048)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 3.  MASAKI Kambara (90103085)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  UEDA Masatoshi (00067117)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  MIYAMAE Masami (20298821)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  GODA Seiji (70351476)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  MIYAKE Tatsuro (40200141)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  MASUZAKI Hiroaki (00291899)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 9.  NOTOHARA Yasuhiro (10548324)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  INOUE Hiroshi (10330143)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  INAMI Kaoru (40548327)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 12.  ARISHIRO Kumiko (20460769)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  KANEDA Kazuhiro (90533886)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  UMEDA Makoto (90193937)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results

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* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

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