HARA Koyu 原好勇

… Alternative Names

原好勇ハラコウユウ

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Researcher Number	40309753
Other IDs
Affiliation (Current)	2025: 久留米大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2012 – 2024: 久留米大学, 医学部, 准教授 2007 – 2008: 久留米大学, 医学部, 講師 2000 – 2002: 久留米大学, 医学部, 講師 1999: 久留米大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Biological Sciences / Pediatrics / Virology Except Principal Investigator Pediatrics / Respiratory organ internal medicine
Keywords	Principal Investigator RNAポリメラーゼ / Pタンパク質 / 抗ウイルス薬 / RSV / パラミクソウイルス / 相互作用 / プロテアーゼ / PAサブユニット / インフルエンザウイルス / モノネガウイルス … More / P / RSウイルス / リバースジェネティクス / 活性阻害 / マトリックスタンパク質 / ナノ粒子 / ペプチドベース阻害薬 / PFr / 4量体形成部位 / ペプチド阻害薬 / 下気道感染症 / 乳幼児 / ペプチド薬剤 / Lポリメラーゼ / ポリメラーゼ / ペプチド / RNP / 非翻訳領域 / 欠損変異型 / 抗ウイルス作用 / ミニゲノムアッセイ系 / RNA複製酵素 / Lタンパク質 / ルシフェラーゼ / ミニゲノム / 立体構造 … More Except Principal Investigator 阻害薬 / PA / PB2 / ポリメラーゼ / PAサブユニット / 抗ウイルス薬 / RNAポリメラーゼ / インフルエンザウイルス / インフルエンザ / 生理活性 / 酵素 / 核酸 / 感染症 / ウイルス / Small RNA / PB2サブユニット / 遺伝子複製 / タイ / 市中肺炎 Less

Pタンパク質の4量体を破壊する広域抗モノネガウイルス薬の開発研究Principal Investigator
- Principal Investigator
  
  原好勇
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
A universal design of nanoparticle-based antivirals against paramyxovirusesPrincipal Investigator
- Principal Investigator
  
  Hara Koyu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
A novel antiviral strategy against respiratory syncytial virus disrupting protein-protein interactionsPrincipal Investigator
- Principal Investigator
  
  Hara Koyu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Development of new drug based on the self or non-self distinctional mechanism of the influenza virus
- Principal Investigator
  
  KASHIWAGI TAKAHITO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Establishment of a new therapeutic for the treatment of paramyxoviruses by using a mimic of viral genomic RNA.Principal Investigator
- Principal Investigator
  
  Hara Koyu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
New strategy of the therapy that applied antigenic-shift of the influenza virus.
- Principal Investigator
  
  KASHIWAGI takahito
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Clinical study concerning the relationship between community-acquiredpneumonia and influenza in Thailand
- Principal Investigator
  
  WATANABE Hiroshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kurume University
新たに発見したPAプロテアーゼを標的とした抗インフルエンザウイルス薬の開発Principal Investigator
- Principal Investigator
  
  原好勇
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
新たに発見したPAプロテアーゼを標的とした抗インフルエンザウイルス薬の開発Principal Investigator
- Principal Investigator
  
  原好勇
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kurume University
インフルエンザウイルスPA,PB2蛋白の立体構造解明と阻害剤の開発Principal Investigator
- Principal Investigator
  
  原好勇
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  Kurume University

[Book] 特集:インフルエンザを取り巻く治療・予防の現状と課題。IV.インフルエンザの臨床像と診断2007
- Author(s)
  原好勇、渡邊浩
- Publisher
  Progress in Medicine,ライフ・サイエンス
- Data Source
  KAKENHI-PROJECT-18406030
[Book] 特集 : インフルエンザを取り巻く治療・予防の現状と課題。IV. インフルエンザの臨床像と診断。Progress in Medicine 272007
- Author(s)
  原好勇, 渡邊浩
- Data Source
  KAKENHI-PROJECT-18406030
[Journal Article] A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein.2020
- Author(s)
  Hara K, Yaita K, Khamrin P, Kumthip K, Kashiwagi T, Eleouet JF, Rameix-Welti MA, Watanabe H.
- Journal Title
  
  J Gen Virol
  
  Volume: 101 Issue: 1 Pages: 21-32
- DOI
  10.1099/jgv.0.001350
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07834
[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication.2017
- Author(s)
  K. Hara, T. Kashiwagi, N. Hamada, H. Watanabe
- Journal Title
  
  J. Gen. Virol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10047
[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication2017
- Author(s)
  Hara Koyu、Kashiwagi Takahito、Hamada Nobuyuki、Watanabe Hiroshi
- Journal Title
  
  Journal of General Virology
  
  Volume: 98 Issue: 5 Pages: 900-905
- DOI
  10.1099/jgv.0.000750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10047
[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication.2017
- Author(s)
  Hara K, Kashiwagi T, Hamada N, and Watanabe H.
- Journal Title
  
  J. Gen. Virol
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09672
[Journal Article] マイクロRNAをかわすウイルスたち2016
- Author(s)
  原　好勇
- Journal Title
  
  久留米医学会雑誌
  
  Volume: 79 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-15K09672
[Journal Article] The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via supression of its RNP expression.2015
- Author(s)
  Uemura Y, Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H.
- Journal Title
  
  J Infect Chemother
  
  Volume: 21 Pages: 296-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09672
[Journal Article] The N-terminal fragment of PA subunit of the influenza A virus effectively inhibits ribonucleoprotein (RNP) activity via supression of its RNP expression.2015
- Author(s)
  Uemura Y, Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H.
- Journal Title
  
  J Infect Chemother
  
  Volume: 21 Issue: 4 Pages: 296-301
- DOI
  10.1016/j.jiac.2014.12.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] Performance of a rapid human metaneumovirus antigen test during an outbreak in a long-term care facility.2014
- Author(s)
  Hamada N, Hara K, Matsuo Y, Imamura Y, Kashiwagi T, Nakazono Y, Gotoh K, Ohtsu Y, Ohtaki E, Motohiro T and Watanabe H.
- Journal Title
  
  Epidemiol Infect
  
  Volume: 142 Issue: 2 Pages: 424-427
- DOI
  10.1017/s0950268813001246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] The N-terminal fragment of a PB2 subunit from the influenza A virus (A/Hong Kong/156/1997 H5N1) effectively inhibits RNP activity and viral replication.2014
- Author(s)
  Kashiwagi T, Hara K, Nakazono Y, Uemura Y, Imamura Y, Hamada N, and Watanabe H.
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 12 Pages: e114502-e114502
- DOI
  10.1371/journal.pone.0114502
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexs2013
- Author(s)
  K Hara, Y Nakazono, T Kashiwagi, N Hamada and H Watanabe
- Journal Title
  
  Journal of general virology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591590
[Journal Article] Performance of a rapid human metaneumovirus antigen test during an outbreak in a long-term care ficility2013
- Author(s)
  N Hamada, K Hara, Y Matsuo, Y Imamura, T Kashiwagi, Y Nakazono, K Gotoh, E Ohtaki, T Motohiro and H Watanabe
- Journal Title
  
  Epidemiology and infection
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591590
[Journal Article] インフルエンザ（H1N1）2009発生時に地域に密着して実施した実験室内診断症例の検討2013
- Author(s)
  今村宜寛、濱田信之、原好勇、柏木孝仁、渡邊浩
- Journal Title
  
  感染症学雑誌
  
  Volume: 87(3) Pages: 368-374
- NAID
  10031189392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591590
[Journal Article] Co-incorporation of the PB2 and PA polymerase subunits from human H3N2 influenza virus is a critical determinant of the replication of reassortant ribonucleoprotein complexes.2013
- Author(s)
  Hara K, Nakazono Y, Kashiwagi T, Hamada N, and Watanabe H.
- Journal Title
  
  J. Gen. Virol
  
  Volume: 94 Issue: 11 Pages: 2406-2416
- DOI
  10.1099/vir.0.053959-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] The RNA polymerase PB2 subunit of influenza A/HongKong/156/1997 (H5N1) restricts the replication of reassortant ribonucleoprotein complexes2012
- Author(s)
  Nakazono Y Hara K, Kashiwagi T, Hamada N, Watanabe H
- Journal Title
  
  PLoS ONE
  
  Volume: 7(2) Issue: 2 Pages: e32634-e32634
- DOI
  10.1371/journal.pone.0032634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591305, KAKENHI-PROJECT-21791015, KAKENHI-PROJECT-24591495, KAKENHI-PROJECT-24591590
[Journal Article] Intrahost emergent dynamics of oseltamivir-resistant virus of pandemic influenza A (H1N1) 2009 in a fatally immunocompromised patient.2012
- Author(s)
  N Hamada, Y Imamura, K Hara, T Kashiwagi, Y Imamura, Y Nakazono, K Chijiwa, and H Watanabe
- Journal Title
  
  Journal of infection and chemotherapy
  
  Volume: 18 Issue: 6 Pages: 865-871
- DOI
  10.1007/s10156-012-0429-0
- NAID
  10031143888
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591590
[Journal Article] A nosocomial outbreak of epidemic keratoconjunctivitis accompanyingenvironmental contamination with adenovimses2008
- Author(s)
  Hamada N, Gotoh K, Hara K, Iwahashi J, Imamura Y, Nakamura S, Taguchi C, Sugita M, Yamakawa R, Etoh Y, Sera N, Ishibashi T, Chijiwa K, and Watanabe H.
- Journal Title
  
  Joumal of Hospital Infection 68
  
  Pages: 262-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406030
[Journal Article] A nosocomial outbreak of epidemic keratoconjunctivitis accompanying environmental contamination with adenoviruses.2008
- Author(s)
  Hamada N, Gotoh K, Hara K, I wahashi J, Imamura Y, Nakamura S, Taguchi C, Sugita M, Yamakawa R, Etoh Y, Sera N, Ishibashi T, Chijiwa K, Watanabe H.
- Journal Title
  
  Journal of Hospital Infection 68
  
  Pages: 262-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406030
[Journal Article] A mutational shift from domain III to II in the ribosomal entry site of hepatitis C virus with interferon-ribavirin therapy.2008
- Author(s)
  Ogata K, Kashiwagi T, Iwahashi J, Hara K, Honda H, Ide T, Kumashiro R, Kohara M, Sata M, Watanabe H, Hamada N.
- Journal Title
  
  Archives of Virology 153
  
  Pages: 1575-1579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406030
[Journal Article] Clinical and microbiological characteristics of community-acquired pneumonia among HIV-infected patients in northern Thailand.2008
- Author(s)
  Watanabe H, Asoh N, Kobayashi S, Watanabe K, Oishi K, Kositsakulchai W, Sanchai T, Khantawa B, Tharavichitkul P, Sirisanthana T, Nagatake T.
- Journal Title
  
  J Infect Chemother 14
  
  Pages: 105-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406030
[Journal Article] Clinical and microbiological characteristics of community-acquired pneumonia among HIV-infected patients in northern Thailand.2008
- Author(s)
  Watanabe H, Asoh N, Kobayashi S, Watanabe K, Oishi K, Kositsakulchai W, Sanchai T, Khantawa B, Tharavichitkul P, Sirisant hana T, Nagatake T.
- Journal Title
  
  Journal of Infection and Chemotherapy 14
  
  Pages: 105-109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406030
[Journal Article] A nosocomial outbreak of epidemic keratoconjunctivitis accompanying environmental contamination with adenoviruses.2008
- Author(s)
  Hamada N, Gotoh K, Hara K, Iwahashi J, Imamura Y, Nakamura S, Taguchi C, Sugita M, Yamakawa R, Etoh Y, Sera N, Ishibashi T, Chijiwa K, Watanabe H.
- Journal Title
  
  J Hosp Infect 68
  
  Pages: 262-268
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18406030
[Presentation] Pタンパク質を標的とした抗パラミクソウイルス薬の設計2023
- Author(s)
  原　好勇
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K07763
[Presentation] RNAポリメラーゼの必須因子Pを標的とした抗ウイルス薬の開発研究2022
- Author(s)
  原　好勇、渡邊　浩
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-21K07763
[Presentation] New approach for inhibiting respiratory syncytial virus infection.2020
- Author(s)
  Koyu Hara
- Organizer
  U.S.-Japan Cooperative Medical Sciences Program (USJCMSP) 22nd
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] A new approach for inhibiting respiratory syncytial virus infection.2020
- Author(s)
  Koyu Hara
- Organizer
  U.S. Japan Cooperative Medical Sciences Program (USJCMSP) 22nd Acute Respiratory Infections (ARI) Panel Meeting; Viral Diseases.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] ウイルスRNAポリメラーゼ複合体由来のP断片は抗RSウイルス活性を示す2019
- Author(s)
  原好勇、柏木孝仁、渡邊浩
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] インフルエンザウイルスRNAポリメラーゼPB2サブユニットのN末領域は転写および複製に関与している2019
- Author(s)
  原　好勇
- Organizer
  第89回日本感染症学会西日本地方会学術集会
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] 精製したRSウイルスのP断片はRSウイルスの増殖を抑制する2019
- Author(s)
  原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第93回日本感染症学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] 精製したRSウイルスのP断片はRSウイルスの増殖を抑制する2019
- Author(s)
  原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第 93回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] RSウイルスの増殖を抑制する欠損型Pの作用機序について2018
- Author(s)
  八板謙一郎、原好勇、柏木孝仁、渡邊浩
- Organizer
  第92回日本感染症学会学術講演会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] RSウイルスの増殖を抑制する欠損型Pの作用機序について2018
- Author(s)
  八板謙一郎、原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第92回日本感染症学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] The C-terminal fragment of the respiratory syncytial virus phosphoprotein inhibits the viral polymerase activity.2018
- Author(s)
  Koyu Hara, Kenichiro Yaita, Takahito Kashiwagi and Hiroshi Watanabe
- Organizer
  Negative Strand RNA Virus meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] RSウイルスの増殖を抑制する欠損型Pの作用機序について2018
- Author(s)
  八板謙一郎、原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第92回日本感染症学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] The C-terminal fragment of the respiratory syncytial virus phosphoprotein inhibits the viral polymerase activity.2018
- Author(s)
  Koyu Hara, Kenichiro Yaita, Takahito Kashiwagi and Hiroshi Watanabe
- Organizer
  Negative Strand Virus meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07834
[Presentation] RSウイルスの欠損型PはRSウイルスのポリメラーゼ活性を阻害する2017
- Author(s)
  八板謙一郎、原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第87回日本感染症学会西日本地方会学術集会
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] 次世代シーケンサーによる病原体不明検体からのコロナウイルスの検出2017
- Author(s)
  濱田信之、原　好勇、柏木孝仁、八板謙一郎、後藤憲志、大津　寧、渡邊　浩
- Organizer
  第91回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] RSウイルスのPタンパク質C末端領域はウイルスRNPの合成を抑制する2017
- Author(s)
  八板謙一郎, 原　好勇, 柏木孝仁, 濱田信之, 渡邊　浩
- Organizer
  第91回日本感染症学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] RSウイルスの欠損型PはRSウイルスのポリメラーゼ活性を阻害する2017
- Author(s)
  八板謙一郎、原　好勇、柏木孝仁、渡邊　浩
- Organizer
  第87回日本感染症学会西日本地方会学術集会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] インフルエンザウイルスのPA断片が持つエンドヌクレアーゼ活性は自身の遺伝子複製阻害に関与する2017
- Author(s)
  上村勇作、柏木孝仁、原　好勇、濱田信之、渡邊　浩
- Organizer
  第91回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] RSウイルスのPタンパク質C末端領域はウイルスRNPの合成を抑制する2017
- Author(s)
  八板謙一郎, 原　好勇, 柏木孝仁, 濱田信之, 渡邊　浩
- Organizer
  第91回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] The C-terminal region of the respiratory syncytial virus phosphoprotein has an inhibitory effect on the polymerase activity.2017
- Author(s)
  Yaita K, Hara K, Khamrin P, Kashiwagi T, Hamada N, and Watanabe H.
- Organizer
  International Union of Microbiological Sciences 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスRNAポリメラーゼPB2サブユニットの転写および複製における役割2017
- Author(s)
  原　好勇、柏木孝仁、濱田信之、渡邊　浩
- Organizer
  第91回日本感染症学会総会
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] 新作用機序によるインフルエンザウイルス阻害剤への応用2016
- Author(s)
  上村勇作、柏木孝仁、原　好勇、濱田信之、渡邊　浩
- Organizer
  第59回日本感染症学会中日本地方会学術集会
- Place of Presentation
  沖縄（沖縄コンベンションセンター）
- Data Source
  KAKENHI-PROJECT-16K10047
[Presentation] The N-terminal fragments of the PB2 and PA subunits severely inhibit a ribonucleoprotein(RNP) activity of influenza A virus.2016
- Author(s)
  Hara K
- Organizer
  US/Japan Cooperative Medical Science Program
- Place of Presentation
  Bethesda, USA
- Year and Date
  2016-01-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] 新作用機序によるインフルエンザウイルス阻害剤への応用2016
- Author(s)
  上村勇作、柏木孝仁、原　好勇、濱田信之、渡邊　浩
- Organizer
  第86回日本感染症学会西日本地方会学術集会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスRNAポリメラーゼPB2サブユニットのRNA結合部位の同定2015
- Author(s)
  原好勇、柏木孝仁、濱田信之、渡邊浩
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] The N-terminal fragments of the PB2 and PA subunits severely inhibit a ribonucleoprotein (RNP) activity of influenza A virus.2015
- Author(s)
  Uemura Y, Kashiwagi T, Hara K, Nakazono Y, Hamada N, and Watanabe H.
- Organizer
  Negative Strand Virus Meeting
- Place of Presentation
  Siena, Italy
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスのN末端PAによるRNP合成阻害とその特異性について2015
- Author(s)
  柏木孝仁、原好勇、上村勇作、今村宜寛、濱田信之、渡邊浩
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] Identification of amino acids critical for polymerase activity in the N-terminal region of the PB2 subunit of influenza virus RNA polymerase.2015
- Author(s)
  Hara K, Kashiwagi T, Hamada N, and Watanabe H.
- Organizer
  Negative Strand Virus Meeting
- Place of Presentation
  Siena, Italy
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] ンフルエンザウイルスのN末端PAによるRNP合成阻害とその特異性について2015
- Author(s)
  柏木孝仁、原　好勇、上村勇作、今村宜寛、濱田信之、渡邊　浩
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  京都
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスRNAポリメラーゼPB2サブユニットのRNA結合部位の同定2015
- Author(s)
  原　好勇、柏木孝仁、濱田信之、渡邊　浩
- Organizer
  第89回日本感染症学会総会
- Place of Presentation
  京都
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-15K09672
[Presentation] インフルエンザウイルスPAサブユニットのN末端断片はRNPの合成を抑制する2014
- Author(s)
  上村勇作、柏木孝仁、原　好勇、濱田信之、渡邊　浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスPA サブユニットのN 末端断片はRNP の合成を抑制する2014
- Author(s)
  上村勇作，柏木孝仁，原好勇，濱田信之，渡邊浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスPAサブユニットによるRNP合成阻害の特異性の検証2014
- Author(s)
  柏木孝仁、上村勇作、原　好勇、今村宜寛、濱田信之、渡邊　浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスA/H3N2の遺伝子再集合ではPB2とPAの同時移行が重要である2014
- Author(s)
  原好勇，柏木孝仁，濱田信之，渡邊浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスPA サブユニットによる RNP 合成阻害の特異性の検証2014
- Author(s)
  柏木孝仁，上村勇作，原好勇，今村宜寛，濱田信之，渡邊浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスA/H3N2の遺伝子再集合ではPB2とPAの同時移行が重要である2014
- Author(s)
  原　好勇、柏木孝仁、濱田信之、渡邊　浩
- Organizer
  第88回日本感染症学会学術講演会
- Place of Presentation
  ヒルトン福岡シーホーク（福岡）
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] The immune response to human metapneumovirus in hospitalized infants.2009
- Author(s)
  Hara K, Watanabe H.
- Organizer
  US-Japan Cooperative Medical Science Program Acute Respiratory Infections Panel.
- Place of Presentation
  Chiba, Japan
- Year and Date
  2009-01-16
- Data Source
  KAKENHI-PROJECT-18406030
[Presentation] The immune response to human metapneumo virus in hospitalized infants.2009
- Author(s)
  Hara K, Watanabe H.
- Organizer
  US-Japan Cooperative Medical Science Program Acute Respiratory Infections Panel.
- Place of Presentation
  Chiba, Japan
- Year and Date
  2009-01-16
- Data Source
  KAKENHI-PROJECT-18406030
[Presentation] インフルエンザウイルスRNPの活性発現にはPB2-PAの組み合わせが重要である
- Author(s)
  原好勇、中園陽子、柏木孝仁、今村宜寛、濱田信之、渡邊浩
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスのPB2とPAは遺伝子再集合を制御する
- Author(s)
  原　好勇、柏木孝仁、濱田信之、渡邊　浩
- Organizer
  第86回日本感染症学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスのPB2サブユニットによるRNAポリメラーゼの阻害効果
- Author(s)
  柏木孝仁、原好勇、中園陽子、今村宜寛、濱田信之、渡邊浩
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] The N-terminal fragment of influenza A virus (H5N1) PB2 subunit strongly inhibits its RNA-dependent RNA polymerase.
- Author(s)
  T Kashiwagi, K Hara, Y Nakazono, Y Uemura, Y Imamura, N Hamada and H Watanabe
- Organizer
  United States-Japan Cooperative Medical Science Program. 16th US-Japan Acute Respiratory Infections Panel Meeting.
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] Co-incorporation of the PB2 and PA polymerase subunits is a critical determinant for the generation of H3N2 reassortant viruses.
- Author(s)
  Hara K, Kashiwagi T, Nakazono Y, Hamada N and Watanabe H
- Organizer
  28th International Congress of Chemotherapy and Infection
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスのPAサブユニットによるＲＮＡポリメラーゼの阻害効果
- Author(s)
  上村勇作、柏木孝仁、原好勇、今村宜寛、濱田信之、渡邊浩
- Organizer
  第87回日本感染症学会学術講演会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスの遺伝子再集合を応用した阻害薬の開発
- Author(s)
  柏木孝仁、原　好勇、今村宜寛、濱田信之
- Organizer
  第86回日本感染症学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] インフルエンザウイルスA/H3N2の遺伝子再集合について
- Author(s)
  原好勇、柏木孝仁、濱田信之、渡邊浩
- Organizer
  第56回日本感染症学会中日本地方会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] PB2サブユニットによるインフルエンザウイルス遺伝子複製酵素の阻害効果に関する研究
- Author(s)
  柏木孝仁、原好勇、上村勇作、今村宜寛、濱田信之、渡邊浩
- Organizer
  第87回日本感染症学会学術講演会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] 重症心身障害児施設でのヒト・メタニューモウイルス集団感染における新規迅速診断キットの有用性
- Author(s)
  濱田信之、原　好勇、松尾勇作、今村宜寛、柏木孝仁、後藤憲志、大津　寧、本廣　孝、渡邊　浩
- Organizer
  第86回日本感染症学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24591590
[Presentation] The N-terminal fragment of influenza A virus (H5N1) PB2 subunit strongly inhibits its RNAdependent RNA polymerase.
- Author(s)
  T Kashiwagi, K Hara, Y Nakazono, Y Uemura, Y Imamura, N Hamada and H Watanabe
- Organizer
  United States-Japan Cooperative Medical Science Program. 16th US-Japan Acute Respiratory Infections Panel Meeting.
- Place of Presentation
  Singapore
- Data Source
  KAKENHI-PROJECT-24591590

1. WATANABE Hiroshi (90295080)

# of Collaborated Projects: 7 results

# of Collaborated Products: 65 results
2. KASHIWAGI takahito (70320158)

# of Collaborated Projects: 6 results

# of Collaborated Products: 50 results
3. HAMADA Nobuyuki (00148793)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. WATANABE Kiwao (20220874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results

HARA Koyu 原 好勇

原 好勇 ハラ コウユウ

Research Projects

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Co-Researchers

Pタンパク質の4量体を破壊する広域抗モノネガウイルス薬の開発研究Principal Investigator

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A universal design of nanoparticle-based antivirals against paramyxovirusesPrincipal Investigator

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A novel antiviral strategy against respiratory syncytial virus disrupting protein-protein interactionsPrincipal Investigator

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Development of new drug based on the self or non-self distinctional mechanism of the influenza virus

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Establishment of a new therapeutic for the treatment of paramyxoviruses by using a mimic of viral genomic RNA.Principal Investigator

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New strategy of the therapy that applied antigenic-shift of the influenza virus.

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Clinical study concerning the relationship between community-acquiredpneumonia and influenza in Thailand

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新たに発見したPAプロテアーゼを標的とした抗インフルエンザウイルス薬の開発Principal Investigator

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新たに発見したPAプロテアーゼを標的とした抗インフルエンザウイルス薬の開発Principal Investigator

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インフルエンザウイルスPA,PB2蛋白の立体構造解明と阻害剤の開発Principal Investigator

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[Book] 特集:インフルエンザを取り巻く治療・予防の現状と課題。IV.インフルエンザの臨床像と診断2007

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[Book] 特集 : インフルエンザを取り巻く治療・予防の現状と課題。IV. インフルエンザの臨床像と診断。Progress in Medicine 272007

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[Journal Article] A small fragmented P protein of respiratory syncytial virus inhibits virus infection by targeting P protein.2020

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[Journal Article] Basic amino acids in the N-terminal half of the PB2 subunit of influenza virus RNA polymerase are involved in both transcription and replication.2017

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Journal Title

HARA Koyu 原好勇

原好勇ハラコウユウ