TAKAHASHI Seiichi 高橋成一

Researcher Number	40312574
Affiliation (based on the past Project Information) *help	2012: 東北大学, 大学病院, 助教 2010 – 2012: 東北大学, 病院, 助教 2007 – 2008: Tohoku University, Tohoku University hospital, Assistant Professor 2005 – 2006: 東北大学, 病院, 助手 2003 – 2006: 東北大学, 病院・助手 2002 – 2003: 東北大学, 医学部附属病院, 助手 2000 – 2001: 東北大学, 医学部・附属病院, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Gastroenterology Except Principal Investigator Gastroenterology / Biological Sciences / Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / gpt / マイクロサテライト / 遺伝子治療 / ジフテリア毒素 / アデニン塩基 / モデルマウス / オートファジー / クローン病 / 小胞体ストレス … More / TNF-SF15 / 発癌 / inflammatory bowel disease / carcinogenesis … More Except Principal Investigator HLA / 感受性遺伝子 / 炎症性腸疾患 / 潰瘍性大腸炎 / クローン病 / TNF-α / IBD3 / テロメア / テロメラーゼ / 大腸癌 / デコイ / NF-κB / センダイウイルス / 自然免疫 / 生体内抗菌ペプチド / 遺伝子多型 / 相関解析 / Crohn's disease / Susceptibility gene / polymorphism / association study / ulcerative colitis / susceptibility gene Less

Tumor necrosis factor ligand superfamily member 15 induces Autophagy in colonic epithelial cellsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Seiichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Establishment of model mice for Inflammatory Bowel DiseasePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Seiichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Identification of a susceptibility gene for ulcerative colitis in 6p
- Principal Investigator
  
  KINOUCHI Yoshitaka
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
The molecular analysis of carcinogenesis in inflamed colon by gpt transgenic mice.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Seiichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
生体内抗菌ペプチドを用いたクローン病新規治療法の開発
- Principal Investigator
  
  木内喜孝
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
炎症性腸疾患のHLA領域内疾患感受性遺伝子の解析
- Principal Investigator
  
  下瀬川徹
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
-κBデコイ型核酸医薬を用いた炎症性腸疾患遺伝子治療の基礎的研究
- Principal Investigator
  
  木内喜孝
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
Analysis of susceptibility gene to Crohn's disease in the HLA region
- Principal Investigator
  
  KINOUCHI Yoshitaka
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
炎症性腸疾患のHLA領域内疾患感受性遺伝子の解析
- Principal Investigator
  
  SHIMOSEGAWA Tooru
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tohoku University
マイクロサテライトの不安定性を利用した遺伝子導入法の確立Principal Investigator
- Principal Investigator
  
  高橋成一
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University
テロメラーゼ活性依存性遺伝子導入法の開発
- Principal Investigator
  
  関根仁
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku University

All 2012 2011 2010 2008 2007 2006

All Journal Article Presentation

[Journal Article] 潰瘍性大腸炎の寛解導入におけるアサコール錠の有用性の検討2012
- Author(s)
  志賀永嗣,遠藤克哉,高橋成一,木内喜孝,下瀬川徹
- Journal Title
  
  消化器内科
  
  Volume: 55巻2号 Pages: 278-286
- NAID
  40019433107
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] 炎症性腸疾患-病因解明と診断・治療の最新知見-炎症性腸疾患の病因と病態炎症性腸疾患の遺伝要因・疾患感受性遺伝子2012
- Author(s)
  木内喜孝,高橋成一,遠藤克哉,志賀永嗣,下瀬川徹
- Journal Title
  
  日本臨床70巻増刊1炎症性腸疾患
  
  Pages: 66-72
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] Changes of faecal microbiota in patients with Crohn's disease treatedwith an elemental diet and total parenteral nutrition2012
- Author(s)
  Shiga H, Kajiura T, Shinozaki J, Takagi S, Kinouchi Y, Takahashi S, Negoro K, Endo K, Kakuta Y, Suzuki M, Shimosegawa T
- Journal Title
  
  Dig Liver Dis
  
  Volume: 44(99) Pages: 736-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] IBD診療の現在腸管外病変の診断と治療2012
- Author(s)
  遠藤克哉,高橋成一,志賀永嗣,木内喜孝,下瀬川徹
- Journal Title
  
  Pharma Medica
  
  Volume: 30巻9号 Pages: 35-39
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] 炎症性腸疾患の薬物療法の極意クローン病に対するインフリキシマブの治療成績と遺伝子多型との関連2012
- Author(s)
  遠藤克哉,諸井林太郎,高橋成一,木内喜孝,下瀬川徹
- Journal Title
  
  消化器内科
  
  Volume: 54巻1号 Pages: 77-82
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] ゲノムワイド関連解析からみえてきた消化器疾患わが国のクローン病の発症要因と治療抵抗性2012
- Author(s)
  角田洋一,木内喜孝,高橋成一,下瀬川徹
- Journal Title
  
  G.I.Research
  
  Volume: 20巻3号 Pages: 196-202
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] Increased expression of NKX2.3 mRNA transcribed from the risk haplotype for ulcerative colitis in the involved colonic mucosa2011
- Author(s)
  Arai T, Kakuta Y, Kinouchi Y, Kimura T, Negoro K, Aihara H, Endo K, Shiga H, Kanazawa Y, Kuroha M, Moroi R, Nagasawa H, Shimodaira Y, Takahashi S, Shimosegawa T
- Journal Title
  
  Hum Immunol
  
  Volume: 2(7) Pages: 587-591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] IBDの疾患感受性遺伝子を知り、治療につなげるここまで明らかになったクローン病の感受性遺伝子2011
- Author(s)
  角田洋一,木内喜孝,高橋成一,下瀬川徹
- Journal Title
  
  IBD Research
  
  Volume: 5巻2号 Pages: 82-88
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] IBDの最近の治療その他の治療法クローン病の栄養療法2011
- Author(s)
  志賀永嗣,高木承,遠藤克哉,高橋成一,木内喜孝,下瀬川徹
- Journal Title
  
  臨床消化器内科
  
  Volume: 27巻1号 Pages: 79-84
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] クローン病の長期予後改善をめざしてクローン病の長期予後2011
- Author(s)
  木内喜孝,角田洋一,高橋成一,下瀬川徹
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 108巻3号 Pages: 381-387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] オートファジーとクローン病2011
- Author(s)
  高橋成一
- Journal Title
  
  IBD Research
  
  Volume: 5巻2号 Pages: 24-31
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] 潰瘍性大腸炎診療の現状と今後の展望潰瘍性大腸炎の病態はどこまで解明されたか?2011
- Author(s)
  木内喜孝,角田洋一,遠藤克哉,志賀永嗣,高橋成一,下瀬川徹
- Journal Title
  
  潰瘍性大腸炎の遺伝子異常Progress in Medicine
  
  Volume: 31巻10号 Pages: 2327-2331
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] 潰瘍性大腸炎の寛解維持療法とサーベイランス2011
- Author(s)
  高橋成一,木内喜孝,下瀬川徹
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 108巻12号 Pages: 1983-1995
- NAID
  10030299028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] 遺伝子多型による消化器疾患の理解遺伝子多型解析から炎症性腸疾患の病因解明は可能か2011
- Author(s)
  木内喜孝,角田洋一,高橋成一,下瀬川徹
- Journal Title
  
  分子消化器病
  
  Volume: 8巻3号 Pages: 212-219
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] 臨床に役立つ腸管免疫学の最新のトピックスIBDの遺伝子異常2011
- Author(s)
  木内喜孝,荒井壮,金澤義丈,角田洋一,遠藤克哉,志賀永嗣,高橋成一,下瀬川徹
- Journal Title
  
  GWASがもたらした病態研究の糸口Intestine
  
  Volume: 15巻5号 Pages: 415-421
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] クローン病の長期予後改善をめざして生物学的製剤によるクローン病の寛解維持療法infliximab計画的維持投与の治療効果を中心に2011
- Author(s)
  遠藤克哉,志賀永嗣,角田洋一,高橋成一,木内喜孝,下瀬川徹
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 108巻3号 Pages: 401-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] 炎症性腸疾患の今日的アプローチ遺伝子異常面からみた炎症性腸疾患2010
- Author(s)
  角田洋一,木内喜孝,高橋成一,下瀬川徹
- Journal Title
  
  成人病と生活習慣病
  
  Volume: 40巻12号 Pages: 1351-1356
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] Scheduled maintenance therapy with infliximab improves the prognosis of Crohn's disease: A single center prospective cohort study in Japan2010
- Author(s)
  Takahashi S, Takagi S, Shiga H, Umemura K, Endo K, Kakuta Y, Takahashi S, Kinouchi Y, Shimosegawa T
- Journal Title
  
  Tohoku J Exp Med
  
  Volume: 220(3) Pages: 207-15
- NAID
  10027083563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] Tooru Shimosegawa. What Determines the Later Clinical Course of Patients Who Do Not Undergo Colectomy at the First Attack? A Japanese Cohort Study on Ulcerative Colitis2010
- Author(s)
  Shiga H, Takagi S, Inoue S, Kinouchi Y, Ohkubo T, Takahashi S, Negoro K, Yokoyama H, Kato S, Fukushima K, Hiwatashi N
- Journal Title
  
  Digestion
  
  Volume: 81(2) Pages: 104-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] クローン病の診断・治療の最前線疾患感受性遺伝子からみたクローン病2010
- Author(s)
  木内喜孝,高橋成一,下瀬川徹
- Journal Title
  
  日本消化器病学会雑誌
  
  Volume: 107巻6号 Pages: 855-862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] Involvement of NF-kappa B pathway in TL1A gene expression induced by lipopolysaccharide2010
- Author(s)
  Endo K, Kinouchi Y, Kakuta Y, Ueki N, Takahashi S, Shimosegawa T
- Journal Title
  
  Cytokine
  
  Volume: 49 Pages: 215-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590693
[Journal Article] 炎症性腸疾患の分子医学2008
- Author(s)
  角田洋一、木内喜孝、高橋成一、下瀬川徹
- Journal Title
  
  「遺伝子変異による発症メカニズム」、Bio Clinica 23(13)
  
  Pages: 18-21
- Data Source
  KAKENHI-PROJECT-19590711
[Journal Article] 疾患関連遺伝子はどこまで明らかにされたか2008
- Author(s)
  木内喜孝、角田洋一、野村栄樹、高橋成一、下瀬川徹
- Journal Title
  
  IBD Research 2(2)
  
  Pages: 149-154
- Data Source
  KAKENHI-PROJECT-19590711
[Journal Article] HLA-DRBI alleles influence clinical phenotypes in Japanese patients with ulcerative colitis2008
- Author(s)
  Matsumura Y, Kinouchi Y, Nomura E, Negoro K, Kakuta Y, Endo K, Aizawa H, Takagi S, Takahashi S, Shimosegawa T
- Journal Title
  
  Tissue Antigens 71(5)
  
  Pages: 447-452
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Journal Article] Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRBI*15022007
- Author(s)
  Mochida A, Kinouchi Y, Negoro K, Takahashi S, Takagi S, Nomura E, Kakuta Y, Tosa M, Shimosegawa T
- Journal Title
  
  Tissue Antigens 70
  
  Pages: 128-135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Journal Article] Lack of association between IBD5 and Crohn''s disease in the Japanese population demonstrates population specific difference in inflammatory bowel disease2006
- Author(s)
  Tosa M, Negoro K, Kinouchi Y, Abe H, Nomura E, Takagi S, Aihara H, Oomori S, Sugimura M, Takahashi K, Hiwatashi N, Takahashi S, Shimosegawa T.
- Journal Title
  
  Scand J Gastroenterol 41
  
  Pages: 48-53
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Journal Article] Associationstudy of TNFSF 15 polymorphisms in Japanese patients with inflammatory bowel disease2006
- Author(s)
  Kakuta Y, Kinouchi Y, Negoro K, Takahashi S, Shimosegawa T.
- Journal Title
  
  Gut 55
  
  Pages: 1527-1528
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Presentation] FCGR3A遺伝子多型とInfliximabの治療効果の相関から考えるクローン病の基本病態2012
- Author(s)
  諸井林太郎,遠藤克哉,木内喜孝,只野敏浩,川上瑶子,奈良志博,松下勝則,宮澤輝子,下平陽介,長澤仁嗣,志賀永嗣,根来健一,相原裕之,高橋成一,下瀬川徹
- Organizer
  日本消化器病学会総会
- Place of Presentation
  鹿児島
- Year and Date
  2012-03-23
- Data Source
  KAKENHI-PROJECT-22590693
[Presentation] 日本人炎症性腸疾患患者におけるXBP1遺伝子の解析2011
- Author(s)
  長澤仁嗣,角田洋一,奈良志博,平本圭一郎,松下勝則,宮澤輝子,下平陽介,諸井林太郎,黒羽正剛,志賀永嗣,遠藤克哉,高橋成一,木内喜孝,下瀬川徹
- Organizer
  日本消化器関連学会週間
- Place of Presentation
  福岡
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22590693
[Presentation] Association study of tnfsf15 genotype and hla-dqb1*04 with clinical course in japanese patients with crohn''s disease2007
- Author(s)
  Kakuta Y, Kinouchi Y, Matsuura M, Nomura E, Tosa M, Negoro K, Takagi S, Takahashi S, Shimosegawa T.
- Organizer
  15th United European Gastroenterology Week
- Place of Presentation
  Paris
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Presentation] HLA-DRBI may influence disease phenotype in Japanese patients with ulcerative colitis2007
- Author(s)
  Kakuta Y, Matsumura Y, Nomura E, Negoro K, Takagi S, Takahashi S, Kinouchi Y, Shimosegawa T.
- Organizer
  108^<th> annual meeting of American Gastroenterological Association
- Place of Presentation
  Washington DC
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Presentation] Analysis of genetic interaction between TNFSF15 and DRB1*04 in Japanese patients with Crohn''s disease2007
- Author(s)
  Kakuta Y, Kinouchi Y, Negoro K, Nomura E, Takagi S, Takahashi S, Shimosegawa T.
- Organizer
  108^<th> annual meeting of American Gastroenterological Association
- Place of Presentation
  Washington DC
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Presentation] TNFSF genotype is associated with anal lesions and frequent relapse in Crohn''s disease2007
- Author(s)
  Nomura E, Matuura M, Kakuta Y, Negoro K, Takagi S, Takahashi S, Kinouchi Y, Shimosegawa T.
- Organizer
  108^<th> annual meeting of American Gastroenterological Association
- Place of Presentation
  Washington DC
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Presentation] Candidate gene analysis of Runxl and Padi4 in Japanese patients with inflammatory bowel disease2006
- Author(s)
  Tosa M, Kinouchi Y, Negoro K, Nomura E, Kakuta Y, Abe H, bnai G, Mochida A, Takagi S, Takahashi S, Shimosegawa T.
- Organizer
  107^<th> annual meeting of American Gastroenterological Association
- Place of Presentation
  Los Angeles
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Presentation] Case-control association study of TNFSF15 polymorphisms in the Japanese patients with Crohn''s disease and ulcerative colitis2006
- Author(s)
  Kakuta Y, Kinouchi Y. Negoro K, Matsuura M, Abe H, Imai G, Mochida A, Tosa M, Nonmra E, Takagi S, Takahashi S, Shimosegawa T.
- Organizer
  107^<th>annual meeting of American Gastroenterological Association
- Place of Presentation
  Los Angeles
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212
[Presentation] Analysis of positional candidate gene HLA-B in Japanese patients with ulcerative colitis2006
- Author(s)
  Nomura E, Kinouchi Y. Imai G, Kakuta Y, Abe H, Tosa M, Mochida A, Negoro K, Takagi S, Hiwatashi N, Takahashi S, Hiwatashi N, Shimosegawa T.
- Organizer
  107^<th> annual meeting of American Gastroenterological Association
- Place of Presentation
  Los Angeles
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390212

1. KINOUCHI Yoshitaka (20250780)

# of Collaborated Projects: 8 results

# of Collaborated Products: 35 results
2. SHIMOSEGAWA Tooru (90226275)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. UENO Yoshiyuki (70282126)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NEGORO Kenichi (50375028)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. TAKAGI Shou (50400346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. ENDO Katsuya (40509197)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
7. 樋渡信夫 (00133950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 関根仁 (90241596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAHASHI Seiichi 高橋 成一

Research Projects

Research Products

Co-Researchers

Tumor necrosis factor ligand superfamily member 15 induces Autophagy in colonic epithelial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of model mice for Inflammatory Bowel DiseasePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Identification of a susceptibility gene for ulcerative colitis in 6p

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular analysis of carcinogenesis in inflamed colon by gpt transgenic mice.Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

生体内抗菌ペプチドを用いたクローン病新規治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Research Field

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炎症性腸疾患のHLA領域内疾患感受性遺伝子の解析

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-κBデコイ型核酸医薬を用いた炎症性腸疾患遺伝子治療の基礎的研究

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Analysis of susceptibility gene to Crohn's disease in the HLA region

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炎症性腸疾患のHLA領域内疾患感受性遺伝子の解析

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Review Section

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マイクロサテライトの不安定性を利用した遺伝子導入法の確立Principal Investigator

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テロメラーゼ活性依存性遺伝子導入法の開発

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[Journal Article] 潰瘍性大腸炎の寛解導入におけるアサコール錠の有用性の検討2012

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NAID

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[Journal Article] 炎症性腸疾患-病因解明と診断・治療の最新知見-炎症性腸疾患の病因と病態炎症性腸疾患の遺伝要因・疾患感受性遺伝子2012

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[Journal Article] Changes of faecal microbiota in patients with Crohn's disease treatedwith an elemental diet and total parenteral nutrition2012

TAKAHASHI Seiichi 高橋成一