Yoshizawa Tatsuya 吉澤達也

… Alternative Names

YOSHIZAWA TATSUYA 吉澤達也

YOSHIZAWA Tatsuya 吉澤達也

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Researcher Number	40313530
Other IDs	https://orcid.org/0000-0002-5728-1996
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 教授
Affiliation (based on the past Project Information) *help	2024: 京都府立医科大学, 医学(系)研究科(研究院), 教授 2015 – 2023: 熊本大学, 大学院生命科学研究部(医), 准教授 2014 – 2015: 熊本大学, 大学院生命科学研究部, 准教授 2014: 熊本大学, 生命科学研究科, 准教授 2013: 熊本大学, 生命科学研究部, 講師 … More 2011 – 2013: 熊本大学, 大学院生命科学研究部, 講師 2007: 新潟大, 医歯学系, 助手 2005 – 2006: 新潟大学, 医歯学系, 助手 2001 – 2004: Graduate School of Medical and Dental Sciences, Niigata University, Assistant, 大学院・医歯学総合研究科, 助手 1999 – 2000: Faculty of Dentistry, Niigata University Assistant, 歯学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Functional basic dentistry / Biological Sciences / Orthopaedic surgery / Pathological medical chemistry / Metabolomics / Functional basic dentistry Except Principal Investigator Functional basic dentistry / Basic Section 57050:Prosthodontics-related … More / Basic Section 54040:Metabolism and endocrinology-related / Social dentistry / Metabolomics / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Functional basic dentistry / Prosthetic dentistry Less
Keywords	Principal Investigator サーチュイン / アシル化 / 骨芽細胞 / 骨格筋 / 運動器 / 骨 / 石灰化 / 骨組織 / 腸管 / 糖代謝 … More / インスリン / シグナル伝達 / 靭帯 / 歯根膜 / 細胞分化 / グルココルチコイドレセプター / グルココルチコイド / 臓器連関 / ホルモン / アシル化修飾 / 脂肪酸アシル化 / 神経幹細胞 / タンパク質翻訳後修飾 / 幹細胞 / 間葉系幹細胞 / 骨代謝 / Osterix / ロコモティブシンドローム / 老化 / SIRT7 / 骨粗鬆症 / インスリン受容体 / 糖尿病 / 機械的刺激 / 細胞・組織 / 後縦靱帯骨化症 / 靱帯 / Msx2 / Runx2 / 後縦靭帯骨化症 / 分子生物学 / 細胞生物学 / 硬組織 / セメント芽細胞 / 歯根膜細胞 … More Except Principal Investigator SIRT7 / サーチュイン / メカニカルストレス / 破骨細胞 / 褐色脂肪細胞 / 脂肪細胞 / 骨 / Msx2 / OPLL / α-adaptin C / 遺伝子発現 / 骨形成 / 骨芽細胞分化 / 骨芽細胞 / 糖尿病 / シクロデキストリン / 褐色脂肪組織 / PIASxβ / Osteogenesis / Osteoblast differentiation / BMP-4 / Mechanical stress / スフィンゴミエリン合成酵素 / 骨代謝 / インスリン / 転写因子 / FGF21 / 寿命 / IMP2 / 糖新生 / ポリロタキサン / 骨吸収 / 炎症 / アシル化修飾 / アシル化 / アセチル化 / PPARgamma / PPARg / PPARγ / エネルギー代謝 / サーチュン / DDB1 / 褐色脂肪 / ユビキチンリガーゼ複合体 / TR4 / 肝臓 / ＳＩＲＴ７ / 脂肪肝 / 細胞・組織 / 細胞膜 / スフィンゴミエリン / スフィンゴ脂質 / osterix / integrins / mechanism of mineralization / osteoblasts / ligament cells / mechanical stress / PIASXβ / Osterix / インテグリン / 石灰化抑制機構 / 靭帯細胞 / Mineralization / Periodontal ligament / 歯芽細胞 / エンドサイトーシス / 石灰化 / 歯根膜細胞 / Tetranectin / BMP - 4 / Tensile stress / 網羅的遺伝子クローニング / sIL-1RAcP / α-adaptinC / クローニング / gene cloning / osteoblast differentiation / osteogenesis / 遺伝子クローニング / in situ hybridization / 糖代謝 / 破骨細胞分化因子 / グルコキナーゼ / HNF / MODY / インスリン分泌 / ヒアルロン酸 Less

The elucidation of the homeostatic mechanisms mediated by posttranslationally lipid modified proteins with musculoskeletal system as a key themePrincipal Investigator
- Principal Investigator
  
  吉澤達也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyoto Prefectural University of Medicine
  Kumamoto University
破骨細胞をターゲットにした超分子による骨吸収抑制治療薬の新たなアプローチ
- Principal Investigator
  
  吉川美弘
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Osaka Dental University
Elucidation of the novel transcriptional regulatory mechanism to separate glucocorticoid actions.Principal Investigator
- Principal Investigator
  
  Yoshizawa Tatsuya
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kumamoto University
Regulation of glucose metabolism by SIRT7
- Principal Investigator
  
  山縣和也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
Regulation of osteoclast function by bone-binding supramolecules
- Principal Investigator
  
  YOSHIKAWA Yoshihiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Osaka Dental University
New roles of bone tissue in the maintenance of homeostasis.Principal Investigator
- Principal Investigator
  
  Yoshizawa Tatsuya
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kumamoto University
Elucidation of regulatory mechanism in musculoskeletal homeostasis by middle-chain fatty acylated proteins.Principal Investigator
- Principal Investigator
  
  Yoshizawa Tatsuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kumamoto University
Molecular mechanism of metabolic regulation through protein acylations
- Principal Investigator
  
  Yamagata Kazuya
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kumamoto University
Identification of the metabolic roles of SIRT7 and the development of its regulation.
- Principal Investigator
  
  Yamagata Kazuya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
中長鎖脂肪酸アシル化修飾タンパク質による運動器を基軸とした代謝調節機構の解明Principal Investigator
- Principal Investigator
  
  吉澤達也
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Kumamoto University
Elucidation of egulatory mechanism of bone metabolism by lysine deacylase SIRT7.Principal Investigator
- Principal Investigator
  
  Yoshizawa Tatsuya
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kumamoto University
Study of the mechanism of sphingolipids on bone metabolism
- Principal Investigator
  
  YOSHIKAWA YOSHIHIRO
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Osaka Dental University
タンパク質リジンアシル化修飾の調節による幹細胞システムの制御とその加齢変化Principal Investigator
- Principal Investigator
  
  吉澤達也
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Identification of the multifaceted metabolic roles of SIRT7
- Principal Investigator
  
  Yamagata Kazuya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
The new function of insulin in gut.Principal Investigator
- Principal Investigator
  
  Yoshizawa Tatsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University
Sphingomyelin regulates blood glucose levels by bone tissue
- Principal Investigator
  
  YOSHIKAWA Yoshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Osaka Dental University
Molecular mechanism of diabetes mellitus based on beta-cell transcription factor network
- Principal Investigator
  
  Yamagata Kazuya
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Study of the new insulin action in the peripheral tissuesPrincipal Investigator
- Principal Investigator
  
  YOSHIZAWA TATSUYA
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
The availability of elderly-friendly macromolecule polysaccharide in periodontal tissue.
- Principal Investigator
  
  KAWAMOTO Akiyo
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Osaka Dental University
石灰化促進・抑制機構を骨芽細胞と靭帯線維芽細胞を用いて探るPrincipal Investigator
- Principal Investigator
  
  吉澤達也
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Niigata University
Cell-specific response to mechanical stress and regulatory mechanism of differentiation : ligament/tendon cells versus osteoblasts
- Principal Investigator
  
  KAWASHIMA Hiroyuki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Niigata University
歯根膜細胞の特性と分化制御機構の解析Principal Investigator
- Principal Investigator
  
  吉澤達也
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Niigata University
Molecular mechanism of osteogenesis-induced osteogenesis
- Principal Investigator
  
  KAWASHIMA Hiroyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Niigata University
歯根膜細胞から硬組織形成系細胞への分化制御機構の解析Principal Investigator
- Principal Investigator
  
  吉澤達也
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Niigata University
On the analysis and regulatory mechanism of genes responsible for mechanical stress-induced osteoblast differentiation and osteogenesis
- Principal Investigator
  
  KAWASHIMA Hiroyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Niigata University
Mechanism of mechanical stress-induced osteoblast differentiation and osteogenesis
- Principal Investigator
  
  KAWASHIMA Hiroyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Niigata University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2004 Other

All Journal Article Presentation

[Journal Article] Hypoxia causes pancreatic β‐cell dysfunction and impairs insulin secretion by activating the transcriptional repressor BHLHE402023
- Author(s)
  Tsuyama Tomonori、Sato Yoshifumi、Yoshizawa Tatsuya、Matsuoka Takaaki、Yamagata Kazuya
- Journal Title
  
  EMBO reports
  
  Volume: 24 Issue: 8
- DOI
  10.15252/embr.202256227
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18302, KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-23K24388
[Journal Article] The Emerging Role of SIRT7 in Glucose and Lipid Metabolism2023
- Author(s)
  Yamagata Kazuya、Mizumoto Tomoya、Yoshizawa Tatsuya
- Journal Title
  
  Cells
  
  Volume: 13 Issue: 1 Pages: 48-48
- DOI
  10.3390/cells13010048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18302, KAKENHI-PROJECT-23K19568, KAKENHI-PROJECT-23K24388
[Journal Article] SIRT7 suppresses energy expenditure and thermogenesis by regulating brown adipose tissue functions in mice2022
- Author(s)
  Yoshizawa Tatsuya、Sato Yoshifumi、Sobuz Shihab U.、Mizumoto Tomoya、Tsuyama Tomonori、Karim Md. Fazlul、Miyata Keishi、Tasaki Masayoshi、Yamazaki Masaya、Kariba Yuichi、Araki Norie、Araki Eiichi、Kajimura Shingo、Oike Yuichi、Braun Thomas、Bober Eva、Auwerx Johan、Yamagata Kazuya
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 7439-7439
- DOI
  10.1038/s41467-022-35219-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08533, KAKENHI-PROJECT-22K08187, KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H04107, KAKENHI-PROJECT-23K24388, KAKENHI-PROJECT-19H03772, KAKENHI-PROJECT-22F22111
[Journal Article] SIRT7 Deficiency Protects against Aging-Associated Glucose Intolerance and Extends Lifespan in Male Mice2022
- Author(s)
  Mizumoto Tomoya、Yoshizawa Tatsuya、Sato Yoshifumi、Ito Takaaki、Tsuyama Tomonori、Satoh Akiko、Araki Satoshi、Tsujita Kenichi、Tamura Masaru、Oike Yuichi、Yamagata Kazuya
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 22 Pages: 3609-3609
- DOI
  10.3390/cells11223609
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08658, KAKENHI-PROJECT-22K19533, KAKENHI-PROJECT-22K16399, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H04107, KAKENHI-PROJECT-23K24388, KAKENHI-PROJECT-23K24805
[Journal Article] Calcium phosphate-adsorbable and acid-degradable carboxylated polyrotaxane consisting of β-cyclodextrins suppresses osteoclast resorptive activity2022
- Author(s)
  YOSHIKAWA Yoshihiro、TAMURA Atsushi、TSUDA Susumu、DOMAE Eisuke、ZHANG Shunyao、YUI Nobuhiko、IKEO Takashi、YOSHIZAWA Tatsuya
- Journal Title
  
  Dent. Mater. J.
  
  Volume: 41 Issue: 4 Pages: 624-632
- DOI
  10.4012/dmj.2021-331
- ISSN
  0287-4547, 1881-1361
- Year and Date
  2022-07-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K10064
[Journal Article] SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARg2.2021
- Author(s)
  Akter F, Tsuyama T, Yoshizawa T, Sobuz SU, Yamagata K
- Journal Title
  
  J Diabetes Invest
  
  Volume: Unknown
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22639
[Journal Article] SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARg2.2021
- Author(s)
  Akter F, Tsuyama T, Yoshizawa T, Sobuz SU, Yamagata K
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 10 Issue: 10 Pages: 1765-1774
- DOI
  10.1111/jdi.13567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-20H04107, KAKENHI-PROJECT-16H06276
[Journal Article] SIRT7 regulates lipogenesis in adipocytes through deacetylation of PPARg2.2021
- Author(s)
  Akter F, Tsuyama T, Yoshizawa T, Sobuz SU, Yamagata K
- Journal Title
  
  J Diabetes Invest
  
  Volume: Unknown
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03711
[Journal Article] Sirt7 Deficiency Attenuates Neointimal Formation Following Vascular Injury by Modulating Vascular Smooth Muscle Cell Proliferation2021
- Author(s)
  木村　優一
- Journal Title
  
  Circ J
  
  Volume: 85 Issue: 12 Pages: 2232-2240
- DOI
  10.1253/circj.CJ-20-0936
- NAID
  130008119968
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2021-11-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15852, KAKENHI-PROJECT-19H03654, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-16H06276
[Journal Article] Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA42020
- Author(s)
  Yamamura Satoru、Izumiya Yasuhiro、Araki Satoshi、Nakamura Taishi、et al.
- Journal Title
  
  Hypertension
  
  Volume: 75 Issue: 1 Pages: 98-108
- DOI
  10.1161/hypertensionaha.119.13357
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08110, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-17K08279, KAKENHI-PROJECT-16H06276
[Journal Article] HNF1α controls glucagon secretion in pancreatic α-cells through modulation of SGLT12020
- Author(s)
  Sato Yoshifumi、Rahman Md Mostafizur、Haneda Masaki、Tsuyama Tomonori、Mizumoto Tomoya、Yoshizawa Tatsuya、Kitamura Tadahiro、Gonzalez Frank J.、Yamamura Ken-ichi、Yamagata Kazuya
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1866 Issue: 11 Pages: 165898-165898
- DOI
  10.1016/j.bbadis.2020.165898
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-20K17538, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-16H06276
[Journal Article] Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes2020
- Author(s)
  Kariba Yuichi、Yoshizawa Tatsuya、Sato Yoshifumi、Tsuyama Tomonori、Araki Eiichi、Yamagata Kazuya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 530 Issue: 3 Pages: 500-507
- DOI
  10.1016/j.bbrc.2020.05.090
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-20K17538, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-16H06276
[Journal Article] Knockdown of sphingomyelin synthase 2 inhibits osteoclastogenesis by decreasing RANKL expression in mouse primary osteoblasts2019
- Author(s)
  YOSHIKAWA Yoshihiro、YOSHIZAWA Tatsuya、DOMAE Eisuke、HIRAI Yuya、KAMADA Aiko、OKAZAKI Toshiro、IKEO Takashi
- Journal Title
  
  Biomed. Res.
  
  Volume: 40 Issue: 5 Pages: 189-196
- DOI
  10.2220/biomedres.40.189
- NAID
  130007724777
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2019-10-01
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K12068
[Journal Article] SIRT7 regulates the nuclear export of NF-κB p65 by deacetylating Ran2019
- Author(s)
  Sobuz Shihab U.、Sato Yoshifumi、Yoshizawa Tatsuya、Karim Fazlul、Ono Katsuhiko、Sawa Tomohiro、Miyamoto Yoichi、Oka Masahiro、Yamagata Kazuya
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  
  Volume: 1866 Issue: 9 Pages: 1355-1367
- DOI
  10.1016/j.bbamcr.2019.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09008, KAKENHI-PROJECT-19K22639, KAKENHI-PROJECT-17H03679, KAKENHI-PROJECT-19H03711, KAKENHI-PROJECT-16H06276
[Journal Article] Angiopoietin-like protein 2 promotes chondrogenic differentiation during bone growth as a cartilage matrix factor.2018
- Author(s)
  Tanoue H, Morinaga J, Yoshizawa T, Yugami M, Itoh H, Nakamura T, Uehara Y, Masuda T, Odagiri H, Sugizaki T, Kadomatsu T, Miyata K, Endo M, Terada K, Ochi H, Takeda S, Yamagata K, Fukuda T, Mizuta H, Oike Y.
- Journal Title
  
  Osteoarthritis Cartilage
  
  Volume: 26 Issue: 1 Pages: 108-117
- DOI
  10.1016/j.joca.2017.10.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08663, KAKENHI-PROJECT-16H05328, KAKENHI-PROJECT-15K06836
[Journal Article] Age-dependent increase in angiopoietin-like protein 2 accelerates skeletal muscle loss in mice.2018
- Author(s)
  Zhao J, Tian Z, Kadomatsu T, Xie P, Miyata K, Sugizaki T, Endo M, Zhu S, Fan H, Horiguchi H, Morinaga J, Terada K, Yoshizawa T, Yamagata K, Oike Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Issue: 5 Pages: 1596-1609
- DOI
  10.1074/jbc.m117.814996
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08663, KAKENHI-PUBLICLY-17H05652, KAKENHI-PROJECT-16H05328, KAKENHI-PROJECT-17F17121, KAKENHI-PROJECT-16K09504, KAKENHI-PROJECT-15K06836, KAKENHI-PROJECT-16K15445, KAKENHI-PROJECT-18K19519
[Journal Article] Sirtuin 7 is involved in the consolidation of fear memory in mice2018
- Author(s)
  Islam Md Safiqul、Wei Fan-Yan、Ohta Kunimasa、Shigematsu Naoki、Fukuda Takaichi、Tomizawa Kazuhito、Yoshizawa Tatsuya、Yamagata Kazuya
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 495 Issue: 1 Pages: 261-266
- DOI
  10.1016/j.bbrc.2017.10.159
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05650, KAKENHI-PROJECT-16H05328
[Journal Article] Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response2018
- Author(s)
  Miyasato Yoshikazu、Yoshizawa Tatsuya、Sato Yoshifumi、Nakagawa Terumasa、Miyasato Yuko、Kakizoe Yutaka、Kuwabara Takashige、Adachi Masataka、Ianni Alessandro、Braun Thomas、Komohara Yoshihiro、Mukoyama Masashi、Yamagata Kazuya
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 5927-5927
- DOI
  10.1038/s41598-018-24257-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09268, KAKENHI-PROJECT-26461234, KAKENHI-PROJECT-17K09705, KAKENHI-PROJECT-17K09706, KAKENHI-PROJECT-16H05328, KAKENHI-PROJECT-16K09758, KAKENHI-PROJECT-16H06276
[Journal Article] SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix2018
- Author(s)
  Fukuda Masatoshi、Yoshizawa Tatsuya et al.
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 2833-2833
- DOI
  10.1038/s41467-018-05187-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06600, KAKENHI-PUBLICLY-17H05650, KAKENHI-PROJECT-16H05328, KAKENHI-PROJECT-17H04105, KAKENHI-PROJECT-15K11027, KAKENHI-PROJECT-16K09758, KAKENHI-PROJECT-17K11014, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H05440
[Journal Article] SIRT7 is an important regulator of cartilage homeostasis and osteoarthritis development.2018
- Author(s)
  Korogi W, Yoshizawa T, Karim MF, Tanoue H, Yugami M, Sobuz SU, Hinoi E, Sato Y, Oike Y, Mizuta H, Yamagata K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 印刷中 Issue: 3 Pages: 891-897
- DOI
  10.1016/j.bbrc.2018.01.129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05328, KAKENHI-PROJECT-16K09758
[Journal Article] Transcriptional regulation of metabolism by SIRT1 and SIRT72017
- Author(s)
  Yamagata K, Yoshizawa T
- Journal Title
  
  Int. Rev. Cel. Mol. Bio.
  
  Volume: 335 Pages: 143-166
- DOI
  10.1016/bs.ircmb.2017.07.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05328
[Journal Article] SIRT7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR42017
- Author(s)
  Karim MF, Yoshizawa T, Sobuz SU, Sato Y, Yamagata K
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 490 Issue: 2 Pages: 423-428
- DOI
  10.1016/j.bbrc.2017.06.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05328
[Journal Article] Hypoxia reduces HNF4alpha/MODY1 protein expression in pancreatic beta-cells by activating AMP-activated protein kinase.2017
- Author(s)
  Sato Y, Karim MF et al.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 印刷中 Issue: 21 Pages: 8716-8728
- DOI
  10.1074/jbc.m116.767574
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K21238, KAKENHI-PROJECT-16K09758, KAKENHI-PROJECT-16H05328
[Journal Article] RNA interference-mediated knockdown of Smad1 inhibits receptor activator of nuclear factor κB ligand expression induced by BMP-2 in primary osteoblasts.2015
- Author(s)
  Yoshikawa Y, Yoshizawa T, Domae E, Hieda Y, Takeyama A, Hirota S, Kawamoto A, Goda S, Tamura I, Kamada A, Komasa Y, Morita S, Yamagata K, Ikeo T.
- Journal Title
  
  Archives of Oral Biology
  
  Volume: 60 Issue: 9 Pages: 1319-26
- DOI
  10.1016/j.archoralbio.2015.06.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26463202, KAKENHI-PROJECT-25293212
[Journal Article] SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.2014
- Author(s)
  Yoshizawa T, Karim Md. F, Sato Y, Senokuchi T, Miyata K, Fukuda T, Go C, Tasaki M, Uchimura K, Kadomatsu T, Tian Z, Smolka C, Sawa T, Kakeya M, Tomizawa K, Ando Y, Araki E, Akaike T, Braun T, Oike Y, Bober E, Yamagata K.
- Journal Title
  
  Cell Metab.
  
  Volume: 9 Issue: 4 Pages: 712-721
- DOI
  10.1016/j.cmet.2014.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24790557, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PROJECT-25293212, KAKENHI-PROJECT-25461114, KAKENHI-PROJECT-25461361, KAKENHI-PROJECT-25870543, KAKENHI-PLANNED-26111008, KAKENHI-PUBLICLY-26116722, KAKENHI-PROJECT-26293190, KAKENHI-PROJECT-26670207, KAKENHI-PROJECT-26670405, KAKENHI-PROJECT-26860697, KAKENHI-PROJECT-26861112
[Journal Article] Homeobox protein Msx2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts.2004
- Author(s)
  T.Yoshizawa et al.
- Journal Title
  
  Molecular and Cellular Biology 24(8)
  
  Pages: 3460-3472
- Data Source
  KAKENHI-PROJECT-15791056
[Journal Article] Homeobox protein Msx2 acts as a molecular-defense mechanism for preventing ossification in ligament fibroblasts2004
- Author(s)
  吉澤達也他7名
- Journal Title
  
  Mol.Cell.Biol. 24・8
  
  Pages: 3460-3472
- Data Source
  KAKENHI-PROJECT-16390531
[Presentation] 脱アシル化酵素SIRT7による運動器恒常性維持機構の解明2023
- Author(s)
  吉澤達也
- Organizer
  第22回運動器科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19714
[Presentation] The diverse functions of NAD-dependent lysine deacylase SIRT7.2021
- Author(s)
  Tatsuya Yoshizawa
- Organizer
  KSBMB (Korean Society for Biochemistry and Molecular Biology) International Conference 2021 (Symposium)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H04107
[Presentation] HNF-1αによる膵α細胞機能制御メカニズムの解明2020
- Author(s)
  佐藤叔史、Md Mostafizur Rahman、羽根田昌樹、水本智也、津山友徳、吉澤達也、北村忠弘、Frank J Gonzalez、山村研一、山縣和也
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19H03711
[Presentation] HNF-1αによる膵α細胞機能制御メカニズムの解明2020
- Author(s)
  佐藤叔史、Md Mostafizur Rahman、羽根田昌樹、水本智也、津山友徳、吉澤達也、北村忠弘、Frank J Gonzalez、山村研一、山縣和也
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K22639
[Presentation] 低酸素誘導性BHLHE40によるβ細胞機能低下機序の解明2019
- Author(s)
  佐藤叔史、津山友徳、吉澤達也、松岡孝昭、山縣和也
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K22639
[Presentation] 低酸素ストレスはBhlhe40-Mafa経路を介してインスリン分泌不全を誘導する2019
- Author(s)
  津山友徳、佐藤叔史、吉澤達也、松岡孝昭、山縣和也
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03711
[Presentation] 脱アセチル化酵素SIRT7によるNF-kB p65の核外輸送制御メカニズムの解明2019
- Author(s)
  佐藤叔史、Sobuz Shihab U.、吉澤達也、Fazlul Karim、小野勝彦、澤智裕、宮本洋一、岡正啓、山縣和也
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K22639
[Presentation] 脱アセチル化酵素SIRT7によるNF-kB p65の核外輸送制御メカニズムの解明2019
- Author(s)
  佐藤叔史、Sobuz Shihab U.、吉澤達也、Fazlul Karim、小野勝彦、澤智裕、宮本洋一、岡正啓、山縣和也
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19H03711
[Presentation] Role of NAD-dependent lysine deacylase in bone.2019
- Author(s)
  吉澤達也
- Organizer
  第16回 Bone Biology Forum
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04676
[Presentation] 低酸素ストレスはBhlhe40-Mafa経路を介してインスリン分泌不全を誘導する2019
- Author(s)
  津山友徳、佐藤叔史、吉澤達也、松岡孝昭、山縣和也
- Organizer
  第42回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-19K22639
[Presentation] 低酸素誘導性BHLHE40によるβ細胞機能低下機序の解明2019
- Author(s)
  佐藤叔史、津山友徳、吉澤達也、松岡孝昭、山縣和也
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19H03711
[Presentation] サーチュインによる骨代謝制御2018
- Author(s)
  吉澤達也
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05650
[Presentation] SIRT７によるエネルギー代謝調節2018
- Author(s)
  吉澤達也
- Organizer
  日本筋学会第4回学術集会　シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04676
[Presentation] サーチュインによる骨代謝制御2018
- Author(s)
  吉澤達也
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K11014
[Presentation] 脱アシル化酵素SIRT7によるエネルギー代謝制御2018
- Author(s)
  吉澤達也
- Organizer
  第72回日本栄養・食糧学会大会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K11014
[Presentation] エクソソームを介した褐色脂肪組織から肝臓への新たな生理作用の解明2018
- Author(s)
  狩場佑一、吉澤達也、山縣和也
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] 脱アシル化酵素SIRT7によるエネルギー代謝制御2018
- Author(s)
  吉澤達也
- Organizer
  第72回日本栄養・食糧学会大会　シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04676
[Presentation] Bhlhe40-Mafa経路を介した低酸素ストレスによるインスリン分泌抑制2018
- Author(s)
  津山友徳、佐藤叔史、吉澤達也、松岡孝昭、山縣和也
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] 脱アシル化酵素SIRT7によるエネルギー代謝制御2018
- Author(s)
  吉澤達也
- Organizer
  第72回日本栄養・食糧学会大会　シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05650
[Presentation] 膵β細胞低酸素によるHNF4蛋白低下メカニズムの解明2017
- Author(s)
  佐藤叔史、津山友徳、佐藤ちなみ、Md. Fazlul Karim、吉澤達也、井上正宏、山縣和也
- Organizer
  日本生化学学会九州支部例会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] SIRT7による多様な代謝制御2017
- Author(s)
  吉澤達也
- Organizer
  ConBio2017 ワークショップ：核内受容体が制御する多彩な生命現象
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05650
[Presentation] 脱アシル化酵素SIRT7によるOsterixの転写活性化は骨形成に重要である2017
- Author(s)
  吉澤達也
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PUBLICLY-17H05650
[Presentation] 脱アシル化酵素SIRT7によるOsterixの転写活性化は骨形成に重要である2017
- Author(s)
  吉澤達也
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K11014
[Presentation] 核内脱アシル化酵素SIRT7は軟骨細胞分化を制御し、変形性膝関節症の発症に関与する2017
- Author(s)
  興梠　航、吉澤達也、山縣和也
- Organizer
  第３５回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] 急性尿細管障害におけるSIRT7の機能解明2017
- Author(s)
  宮里腎和、吉澤達也、中川輝政、柿添　豊、桒原孝成、安達政隆、向山政志、山縣和也
- Organizer
  第２１回日本心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] SIRT7とアンチエイジング2017
- Author(s)
  山縣和也、吉澤達也
- Organizer
  脳心血管抗加齢研究会2017
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] SIRT7による多様な代謝制御2017
- Author(s)
  吉澤達也
- Organizer
  ConBio2017 ワークショップ：核内受容体が制御する多彩な生命現象
- Invited
- Data Source
  KAKENHI-PROJECT-17K11014
[Presentation] SIRT7によるエネルギー代謝制御2017
- Author(s)
  山縣和也、吉澤達也
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] 脱アシル化酵素SIRT7によるOsterixの転写活性化は骨形成に重要である2017
- Author(s)
  吉澤達也、福田雅俊、竹田秀、山縣和也
- Organizer
  第90回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] SIRT7によるエネルギー代謝制御2016
- Author(s)
  吉澤達也、山縣和也
- Organizer
  第３７回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] SIRT7による代謝制御作用2016
- Author(s)
  山縣和也、吉澤達也
- Organizer
  脳心血管抗加齢研究会２０１６
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] Deletion of Sirtuin 7 Ameliorates Cisplatin-Induced Acute Kidney Injury through Regulation of Inflammatory Response.2016
- Author(s)
  Yoshikazu Miyasato, Tatsuya Yoshizawa, Terumasa Nakagawa, Yutaka Kakizoe, Yuichiro Izumi, Takashige Kuwabara, Masataka Adachi, Eva Bober, Masashi Mukoyama, Kazuya Yamagata
- Organizer
  The American Society of Nephrology (ASN) Kidney Week 2016 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] ARNTはARNT/HIF-１αによる血管形成とは独立して直接骨芽細胞の分化を促進する2016
- Author(s)
  福田雅俊、吉澤達也、池亀美華、竹田秀、山縣和也
- Organizer
  第34回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] 代謝制御におけるSIRT7の多様な役割2016
- Author(s)
  吉澤達也、山縣和也
- Organizer
  第８９回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] 核内脱アセチル化酵素SIRT7はOsterixを介して骨形成を制御する2016
- Author(s)
  吉澤達也、福田雅俊、興梠航、竹田秀、山縣和也
- Organizer
  第34回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05328
[Presentation] SIRT7による糖脂質代謝制御2015
- Author(s)
  吉澤達也
- Organizer
  第５８回日本糖尿病学会年次学術集会
- Place of Presentation
  山口市
- Year and Date
  2015-05-21
- Invited
- Data Source
  KAKENHI-PROJECT-25293212
[Presentation] Sirt7遺伝子欠損マウスは、高脂肪食負荷による糖尿病・脂肪肝・肥満に抵抗性である
- Author(s)
  吉澤達也
- Organizer
  第５７回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25293212

1. YOSHIKAWA Yoshihiro (70434793)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
2. Yamagata Kazuya (70324770)

# of Collaborated Projects: 5 results

# of Collaborated Products: 30 results
3. Sato Yoshifumi (90622598)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
4. KAWASHIMA Hiroyuki (40169719)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. ISHIBASHI Osamu (70293214)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. 池尾隆 (40159603)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
7. IKEGAME Mika (70282986)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. KAWAMOTO Akiyo (50368156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. MATSUDA Akio (10359705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 岡崎俊朗 (40233308)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 小野悠介 (60601119)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. OKAZAKI Joji (80169094)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 門松毅 (90555757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 里方一郎 (70170800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 田村篤志 (80631150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 津山友徳 (10845960)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. Sawa Tomohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
18. ENDO Motoyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. KARIM MD・FAZLUL

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 荒木栄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 桑原孝成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshizawa Tatsuya 吉澤 達也

YOSHIZAWA TATSUYA 吉澤 達也

YOSHIZAWA Tatsuya 吉澤 達也

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The elucidation of the homeostatic mechanisms mediated by posttranslationally lipid modified proteins with musculoskeletal system as a key themePrincipal Investigator

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Elucidation of the novel transcriptional regulatory mechanism to separate glucocorticoid actions.Principal Investigator

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New roles of bone tissue in the maintenance of homeostasis.Principal Investigator

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Elucidation of regulatory mechanism in musculoskeletal homeostasis by middle-chain fatty acylated proteins.Principal Investigator

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中長鎖脂肪酸アシル化修飾タンパク質による運動器を基軸とした代謝調節機構の解明Principal Investigator

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Elucidation of egulatory mechanism of bone metabolism by lysine deacylase SIRT7.Principal Investigator

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タンパク質リジンアシル化修飾の調節による幹細胞システムの制御とその加齢変化Principal Investigator

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Yoshizawa Tatsuya 吉澤達也

YOSHIZAWA TATSUYA 吉澤達也

YOSHIZAWA Tatsuya 吉澤達也