Mishima Tatsuya 三嶋竜弥

… Alternative Names

三嶋竜弥ミシマタツヤ

MISHIMA Tatsuya 三嶋竜弥

三嶋竜哉ミシマタツヤ

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Researcher Number	40317095
Other IDs
Affiliation (Current)	2025: 杏林大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 杏林大学, 医学部, 准教授 2023: 杏林大学, 医学部, 准教授 2022: 杏林大学, 医学部, 講師 2018: 杏林大学, 医学部, 助教 2012 – 2015: 杏林大学, 医学部, 助教 … More 2010: 杏林大学, 医学部, 助教 2007 – 2008: 杏林大学, 医学部, 助教 2001 – 2006: 杏林大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Neurophysiology and muscle physiology Except Principal Investigator Anesthesiology/Resuscitation studies / Neurochemistry/Neuropharmacology / Neurochemistry/Neuropharmacology / Anesthesiology/Resuscitation studies / Neurophysiology and muscle physiology
Keywords	Principal Investigator シンタキシン1 / 抑制性シナプス伝達 / アストロサイト / 熱性けいれん / シンタキシン１ / シナプス / 海馬神経細胞 / シンタキシン / 開口放出 / シナプス伝達 / SNARE / syntaxin1 … More Except Principal Investigator … More 膜電位 / ミトコンドリア / membrane potential / mitochondria / ATP / 神経細胞死 / 神経科学 / fluo-3 / 脳虚血 / neuronal death / necrosis / apoptosis / JC-1 / spreading depression / 開口放出 / グリア細胞 / アポトーシス / 細胞死 / syntaxin / 脳・神経 / syntaxin1A / syntaxin1B / 遺伝子ノックアウトマウス / シンタキシン1B / シンタキシン1A / シナプス伝達 / 神経栄養因子 / トランスポーター / 神経伝達物質 / シンタキシン１ / SNARE / オートファジー / アルツハイマー / ERストレス / unipoter / rhod-2 / intracellular calcium / brain ischemia / 細胞内Ca / Akt / uniporter / Rhod-2 / 細胞内カルシウム / TUNEL method / Ca deregultaion / cerebral ischemia / 膜電位依存性色素 / OGD / 培養神経細胞 / ischemia / Apoptosis / hyperpolarization / TUNEL / propofol / mitohocndria / 虚血性神経細胞死 / microdialysis / reperfusion injury / Reactive nitrogen species / Glutathione / Menbrane potential / Mitochondria / Cerebral ischemia / 虚血 / 培養細胞 / 共焦点顕微鏡 / ノックアウトマウス / 神経成長因子 / シンタキシン１B / haploid / 自閉性障害 / 遅い神経伝達物質放出過程 / 速い神経伝達物質放出過程 / シンタキシン１Ｂ / シンタキシン１A / BDNF / 機能分化 / 神経伝達 / MPT / グルタミン酸 / カルシウム / vesicle transport / Golgi / ER-stress / 脳神経疾患 / ストレス / 疾患モデル / 自閉症 / シンタキシン1 / 運動障害 / 痙攣発作 / 致死 / 遅い神経伝達 / 速い神経伝達 / 行動異常 / シナプス伝達制御因子 / シナプス機能分化 / 疾患モデル動物 / ノックアウトマウス自閉性障害 Less

低出力パルス超音波による神経活動抑制効果の作用機序の解明とてんかん治療への応用Principal Investigator
- Principal Investigator
  
  三嶋竜弥
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyorin University
Involvement of astrocytes in the development of febrile seizures due to STX1B haploinsufficiencyPrincipal Investigator
- Principal Investigator
  
  三嶋竜弥
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kyorin University
Role of syntaxin1 in glial cells on the interaction between neurons and glial cells
- Principal Investigator
  
  Kofuji Takefumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyorin University
Role for ER stress responsive ER-Golgi SNARE in processing of Alzheimer`s disease-related protein and autophagy
- Principal Investigator
  
  Suga Kei
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyorin University
Functional difference between syntaxin1 isoforms in synaptic transmission
- Principal Investigator
  
  AKAGAWA kimio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyorin University
Functional role of syntaxin 1B in the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapsesPrincipal Investigator
- Principal Investigator
  
  MISHIMA Tatsuya
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyorin University
Analysis of syntaxin 1 gene knockout mice as an animal model for autistic disorder
- Principal Investigator
  
  AKAGAWA Kimio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyorin University
Role of Syntaxin5 isoforms in neuronal cells under ER stress
- Principal Investigator
  
  SUGA Kei
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyorin University
Brain protection through calcium buffering system in mitochondria
- Principal Investigator
  
  IIJIMA Takehiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyorin University
Pathophysiology of mitochondrial control for neuronal death and brain protection
- Principal Investigator
  
  IIJIMA Takehiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyorin University
Mitochondrial regulation of ishcemic neuronal death
- Principal Investigator
  
  IIJIMA Takehiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyorin University
Brain protection from the neuronal death induced by spreading depression
- Principal Investigator
  
  IIJIMA Takehiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Kyorin University

[Journal Article] Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes2024
- Author(s)
  Mishima T, Komano K, Tabaru M, Kofuji T, Saito A, Ugawa Y, Yasuo Terao
- Journal Title
  
  Front Cell Neurosci.
  
  Volume: 18 Pages: 1-14
- DOI
  10.3389/fncel.2024.1361242
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07926, KAKENHI-PROJECT-22K04134, KAKENHI-PROJECT-22K07943
[Journal Article] Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.2017
- Author(s)
  Fujiwara T, Kofuji T, Mishima T, Akagawa K
- Journal Title
  
  Eur J Neurosci.
  
  Volume: 46 Issue: 12 Pages: 2867-2874
- DOI
  10.1111/ejn.13779
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01954, KAKENHI-PROJECT-16K07064
[Journal Article] Data for the effects of ER and Golgi stresses on the ER-Golgi SNARE Syntaxin5 expression and on the βAPP processing in cultured hippocampal neurons2015
- Author(s)
  Kei Suga, Ayako Saito, Tatsuya Mishima, and Kimio Akagawa
- Journal Title
  
  Data in Brief
  
  Volume: 5 Pages: 114-123
- DOI
  10.1016/j.dib.2015.08.023
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430072
[Journal Article] ER and Golgi stresses increase ER-Golgi SNARE Syntaxin5: Implications for organelle stress and βAPP processing2015
- Author(s)
  Kei Suga, Ayako Saito, Tatsuya Mishima, and Kimio Akagawa
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 604 Pages: 30-35
- DOI
  10.1016/j.neulet.2015.07.017
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25430072
[Journal Article] Syntaxin 1B, but Not Syntaxin 1A, is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses2014
- Author(s)
  T.Mishima, T.fujiwara, M.Sanada, T.Kofuji ,M.Kanai &K.Akagawa
- Journal Title
  
  PLoS ONE.
  
  Volume: 9 Issue: 2 Pages: e90004-e90004
- DOI
  10.1371/journal.pone.0090004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300142, KAKENHI-PROJECT-24500462
[Journal Article] ＨＰＣ－１ｓｙntaxin1A and syntaxin1B play distinct roles in neuronal survival.2014
- Author(s)
  Ｔ．Ｋｏｆｕｊｉ，Ｔ．Ｆｕｊｉｗａｒａ，　Ｍ．Ｓａｎａｄａ，　Ｔ．Ｍｉｓｈｉｍａ　＆　Ｋ．Ａｋａｇａｗａ
- Journal Title
  
  J. Neurochemistry
  
  Volume: 129 Issue: 4 Pages: 514-525
- DOI
  10.1111/jnc.12722
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300142, KAKENHI-PROJECT-24500462
[Journal Article] FRET-based evaluation of Bid cleavage in a single primary cultured neuron.2013
- Author(s)
  Nakazawa H
- Journal Title
  
  Neurosci Lett.
  
  Volume: 536 Pages: 24-28
- DOI
  10.1016/j.neulet.2012.11.059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591717, KAKENHI-PROJECT-25430072
[Journal Article] Impairment of Catecholamine Systems during Induction of Long-Term Potentiation at Hippocampal CAl Synapses in HPC-1/Syntaxin 1A Knock-out Mice2012
- Author(s)
  Mishima T.,
- Journal Title
  
  J.Neuroscience
  
  Volume: 32 Issue: 1 Pages: 381-389
- DOI
  10.1523/jneurosci.2911-11.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300142
[Journal Article] Up-regulation of Syntaxin5 protein expression under ER stress2010
- Author(s)
  K.Suga, A.Saito, T.Mishima, K.Akagawa
- Journal Title
  
  Bull.Jpn.Soc.Neurochem.
  
  Volume: 49(No.2,3) Pages: 631-631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Calcium loading capacity and Ca2+ buffering capacity of mitochondria after oxygen-glucose deprivation in hippocampal neurons.2009
- Author(s)
  K. Tanaka, T. Iijima, T. Mishima, K. Akagawa
- Journal Title
  
  Neurochem. Res Vol.34
  
  Pages: 221-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300133
[Journal Article] Y. Iwao Ca2+ buffering capacity of mitochondria after oxygen-glucose deprivation in hippocampal neurons.2009
- Author(s)
  K. Tanaka, T. Iijima, T. Mishima, K. Suga, K. Akagawa
- Journal Title
  
  Neurochem. Res Vol. 34
  
  Pages: 221-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Ca^<2+> buffering capacity of mitochondria after oxygen-glucose deprivation in hippocampal neurons2009
- Author(s)
  K.Tanaka, T.Iijima, T.Mishima, K.Suga, K.Akagawa, Y.Iwao
- Journal Title
  
  Neurochem.Res. Vol.34
  
  Pages: 221-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Ca^<2+> buffering capacity of mitochondria after oxygen-glucose deprivation in hippocampal neurons2009
- Author(s)
  K. Tanaka, T. Iijima, T. Mishima, K. Suga, K. Akagawa, Y. Iwao
- Journal Title
  
  Neurochem. Res. 34
  
  Pages: 221-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Y. Iwao Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model.2008
- Author(s)
  T. Iijima, K. Tanaka, S. Matsubara, S. Kawakami, T. Mishima, K. Suga, K. Akagawa
- Journal Title
  
  Neurosci. Lett Vol.448
  
  Pages: 268-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Effects of 5-HT signaling on cultured hippocampal neurons of HPC-1/syntaxin1A knock-out mouse2008
- Author(s)
  Takefumi Kofuji, Tomonori Fujiwara, Tatsuya Mishima, Kimio Akagawa
- Journal Title
  
  J. Physiol. Sci 58
  
  Pages: 128-128
- NAID
  130005449606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model2008
- Author(s)
  Iijima T, Tanaka K, Matsubara S, Kawakami H, Mishima T, Suga K, Akagawa K, Iwao Y
- Journal Title
  
  Neuroscience Lett 448(3)
  
  Pages: 268-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591818
[Journal Article] Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model2008
- Author(s)
  T.Iijima, K.Tanaka, S.Matsubara, S.Kawakami, T.Mishima, K.Suga, K.Akagawa, Y.Iwao
- Journal Title
  
  Neurosci.Lett. Vol.448
  
  Pages: 268-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Ca^<2+> buffering capacity of mitochondria after oxygen-glucose deprivation in hippocampal neurons2008
- Author(s)
  Tanaka K, Iijima T, Mishima T, Suga K, Akagawa K, Iwao Y
- Journal Title
  
  Neurochemical Research 34(2)
  
  Pages: 221-226
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591818
[Journal Article] Morphological changes in mitochomdria in an ischemic preconditioned model.2008
- Author(s)
  T. Iijima, K. Tanaka, S. Matsubara, T. Mishima, K. Akagawa
- Journal Title
  
  Neurosci. Lett vol.448
  
  Pages: 268-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300133
[Journal Article] Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model2008
- Author(s)
  Iiiima T, Tanaka K, Matsubara S, Kawakami H, Mishima T, Suga K, Akagawa K, Iwao K
- Journal Title
  
  Neurosci Letter 448(3)
  
  Pages: 268-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591818
[Journal Article] Iwao Y Ca^<2+> buffering capacity of mitochondria after oxygen-glucose deprivation in hippocampal neurons2008
- Author(s)
  Tanaka K, Iijima T, Mishima T, Suga K, Akagawa K
- Journal Title
  
  Neurochemical Research 34(2)
  
  Pages: 221-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591818
[Journal Article] Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model.2008
- Author(s)
  T. Iijima, K. Tanaka, S. Matsubara, S. Kawakami, T. Mishima, K. Suga, K. Akagawa, Y. Iwao
- Journal Title
  
  Neurosci Lett. 448
  
  Pages: 268-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Deletion of HPC-1/syntaxin lA gene causes autistic behavior in mice2007
- Author(s)
  Tomonori Fujiwara, Takefumi Kofuji, Tatsuya Mishima, Takeo Yoshikawa, Kimio Akagawa
- Journal Title
  
  Bull. Jpn. Soc. Neurochem 46
  
  Pages: 498-498
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] cAMP signaling cascade is reduced in hippocampal LTP of HPC-1/syntaxin 1A knock-out mice2007
- Author(s)
  Tatsuya Mishima, Tomonori Fujiwara, Takefumi Kofuji, Kimio Akagawa
- Journal Title
  
  Bull. Jpn. Soc. Neurochem 46
  
  Pages: 575-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19500327
[Journal Article] Neuroprotective effect of propofol on necrosis and apoptosis following oxygen-glucose deprivation--relationship between mitochondrial membrane potential and mode of death.2006
- Author(s)
  Iijima T, Mishima T, Akagawa K, Iwao Y.
- Journal Title
  
  Bain Res. 2006 Jul 12 1099(1)
  
  Pages: 25-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591651
[Journal Article] Neuroprotective effect of propofol on necrosis and apoptosis following oxygen-glucose deprivation-relationship between mitochondrial membrane potential and mode of death.2006
- Author(s)
  Iijima T, Mishima T, Akagawa K, Iwao Y
- Journal Title
  
  Bain Res. 1099(1)
  
  Pages: 25-32
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591651
[Journal Article] Preceding neuroprotective effect of propofol against acute neuronal death is dismissed by subsequent apoptosis following oxygen glucose deprivation in rat cultured hippocampal neurons2006
- Author(s)
  Takehiko Iijima, Tatsuya Mishima
- Journal Title
  
  Brain Research (accepted)
- Data Source
  KAKENHI-PROJECT-17591651
[Journal Article] Mitochondrial hyperpolarization after transient oxygen-glucose deprivation and subsequent apoptosis in cultured rat hippocampal neurons2003
- Author(s)
  Iijima, T., Mishima, T., Akagawa, K., Iwao, Y.
- Journal Title
  
  Brain Res 993
  
  Pages: 140-145
- Data Source
  KAKENHI-PROJECT-15591658
[Journal Article] Mitochondrial membrane potential and intracellular ATP content after transient experimental ischemia in the cultured hippocampal neuron2003
- Author(s)
  Iijima T, Mishima, T., Akagawa, K., Iwao, Y.
- Journal Title
  
  Neurochem Int 43(3)
  
  Pages: 263-269
- Data Source
  KAKENHI-PROJECT-15591658
[Journal Article] Mitochondrial hyperpolarization after transient oxygenglucose deprivation and subsequent apoptosis in cultured rat hippocampal neurons.2003
- Author(s)
  Iijima T, Mishima T, Akagawa K, Iwao Y
- Journal Title
  
  Brain Res 993
  
  Pages: 140-145
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591658
[Journal Article] Mitochondrial hyperpolarization after transient oxygen-glucosedeprivation and subsequent apoptosis in cultured rathippocampal neurons2003
- Author(s)
  Iijima T, Mishima T, Akagawa K, Iwao Y
- Journal Title
  
  Brain Res. 993
  
  Pages: 140-145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591658
[Presentation] 超音波刺激の基礎と臨床2023
- Author(s)
  三嶋竜弥
- Organizer
  第46回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07943
[Presentation] Molecular mechanisms of fever-associated epilepsy syndrome caused by haploinsufficiency of syntaxin 1B2022
- Author(s)
  三嶋竜弥、小藤剛史、寺尾安生
- Organizer
  NEURO2022
- Data Source
  KAKENHI-PROJECT-22K07943
[Presentation] Involvement of syntaxin 1B in the fever-associated epilepsy syndromes: Behavioral and neuronal phenotype of syntaxin 1B gene-ablated mice2018
- Author(s)
  Tatsuya Mishima, Tomonori Fujiwara, Takefumi Kofuji, Yasuo Terao and Kimio Akagawa
- Organizer
  FENS2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Syntaxin1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS2018
- Author(s)
  Tomonori Fujiwara, Takefumi Kofuji, Tatsuya Mishima and Kimio Akagawa
- Organizer
  FENS2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] シンタキシン1Bの熱性けいれんへの関与2018
- Author(s)
  三嶋竜弥、藤原智徳、小藤剛史、寺尾安生、赤川公朗
- Organizer
  第９５回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Role of syntaxin1 in glial cells on providing supportive functions for neurons through trophic support and transmitter uptake2018
- Author(s)
  Takefumi Kofuji, Tomonori Fujiwara, Tatsuya Mishima and Kimio Akagawa
- Organizer
  FENS2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] HPC-1/syntaxin 1A欠損マウスにおける社会行動障害の解析2018
- Author(s)
  藤原智徳、小藤剛史、三嶋竜弥、寺尾安生、赤川公朗
- Organizer
  第９５回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] シンタキシン1B遺伝子欠損マウスのけいれん表現型の解析2017
- Author(s)
  三嶋竜弥、藤原智徳、小藤剛史、寺尾安生、赤川公朗
- Organizer
  第９４回日本生理学会大会
- Place of Presentation
  浜松
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Seizure phenotype in syntaxin1B gene ablated mice was associated with GABAergic system.2017
- Author(s)
  小藤剛史、藤原智徳、三嶋竜弥、赤川公朗
- Organizer
  第６０回日本神経化学会
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Disturbance of HPC-1/syntaxin1A gene expression and variation of its gene number are highly associated with autism spectrum disorder2017
- Author(s)
  Kofuji T, Fujiwara T, Mishima T, Sanada M, Hayashi Y, Tamaru M, Terao Y, Akagawa K
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] シンタキシン１Ｂ遺伝子欠損マウスの行動・神経機能の表現型解析：シンタキシン１Ｂの熱性けいれんへの関与2017
- Author(s)
  三嶋竜弥、藤原智徳、小藤剛史、寺尾安生、赤川公朗
- Organizer
  第４０回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] A study on the behavioral and neuronal phenotype of syntaxin 1B gene-ablated mice: Involvement of syntaxin 1B in the feve-associated epilepsy syndromes2017
- Author(s)
  Mishima T, Fujiwara T, Kofuji T, Terao Y, Akagawa K
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] HPC-1/syntaxin1A regulates reciprocal feedforward interactions between DA and OXT systems, which, in turn, affect social behavior2017
- Author(s)
  Fujiwara T, Kofuji T, Mishima T, Terao Y, Akagawa K
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] HPC-1/syntaxin1A is one of causing gene for autistic spectrum disorder2016
- Author(s)
  藤原智徳、小藤剛史、三嶋竜弥、林優子、田丸政男、赤川公朗
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Disturbance of HPC-1/syntaxin1A gene expression and its CNV cause autistic spectrum disorder2016
- Author(s)
  小藤剛史、藤原智徳、真田ますみ、三嶋竜弥、林優子、田丸政男、赤川公朗
- Organizer
  第５９回日本神経化学会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Upregulation of ER-Golgi SNARE Syntaxin5 by ER stress and its relationship with βAPP processing2015
- Author(s)
  Kei Suga, Ayako Saito, Tatsuya Mishima, and Kimio Akagawa
- Organizer
  第58回日本神経化学会大会
- Place of Presentation
  大宮
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-25430072
[Presentation] HPC-1/STX1AおよびSTX1Bによる社会行動の制御2014
- Author(s)
  藤原智徳、小藤剛史、三嶋竜弥、赤川公朗
- Organizer
  日本生理学会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24500462
[Presentation] シナプス伝達におけるシンタキシン1Bの生理機能2014
- Author(s)
  三嶋竜弥、藤原智徳、真田ますみ、小藤剛史、赤川公朗
- Organizer
  日本生理学会
- Place of Presentation
  鹿児島
- Data Source
  KAKENHI-PROJECT-24500462
[Presentation] ER stress suppress Abeta secretion and induces the expression of ER-Golgi SNARE including Syntaxin5 proteins in neuronal cells2013
- Author(s)
  Suga K, Saito A, Mishima T, Akagawa K
- Organizer
  第56回日本神経化学会大会
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-25430072
[Presentation] STX1A、STX1B欠損マウスにおける行動異常の比較2013
- Author(s)
  藤原智徳、小藤剛史、三嶋竜弥、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24500462
[Presentation] 神経細胞の生存に対するHPC-1/シンタキシン1Aとシンタキシン1Bの異なる役割2013
- Author(s)
  小藤剛史、藤原智徳、真田ますみ、三嶋竜弥、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24500462
[Presentation] 神経細胞における小胞体ストレスはAβ分泌の抑制とSyntaxin5を含むER-Golgi SNAREの発現量の上昇を引き起こす2013
- Author(s)
  須賀圭、齋藤綾子、三嶋竜弥、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24500462
[Presentation] STX1A, STX1B欠損マウスにおける行動異常の比較2013
- Author(s)
  藤原智徳、小藤剛史、三嶋竜也、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] 神経細胞の生存に対するHPC-1/シンタキシン１Ａとシンタキシン１Ｂの異なる役割2013
- Author(s)
  小藤剛史、藤原智徳、真田ますみ、三嶋竜也、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] シナプス伝達におけるシンタキシン1Aとシンタキシン1Bの機能的差異2012
- Author(s)
  三嶋竜弥、藤原智徳、真田ますみ、小藤剛史、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24500462
[Presentation] Functional differences between syntaxin 1A and syntaxin 1B in fast synaptic transmission.2012
- Author(s)
  T. Mishima
- Organizer
  日本神経科学会
- Place of Presentation
  名古屋
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] Up-regulation of Syntaxin5 protein expression under ER stress2010
- Author(s)
  須賀圭,齋藤綾子、三嶋竜弥、赤川公朗
- Organizer
  第53回日本神経化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-19500327
[Presentation] Syntaxin5の発現量は小胞体ストレスにより上昇する2010
- Author(s)
  須賀圭, 齋藤綾子, 三嶋竜弥, 赤川公朗
- Organizer
  第53回日本神経化学会大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-19500327
[Presentation] 小胞体ストレスにおけるSNARE蛋白質の役割2009
- Author(s)
  須賀圭, 齋藤綾子, 三嶋竜弥, 赤川公朗
- Organizer
  第38回杏林医学会
- Place of Presentation
  東京
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-19500327
[Presentation] Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model Keystone Symposia2009
- Author(s)
  Iijima T, Tanaka K, Matsubara S, Kawakami H, Mishima T, Suga K, Akagawa K, Iwao Y
- Organizer
  Mitochondrial dynamics and Physiology
- Place of Presentation
  Whistler, Canada
- Year and Date
  2009-03-24
- Data Source
  KAKENHI-PROJECT-19591818
[Presentation] HPC-1/syntaxin1AノックアウトマウスのLTP異常におけるcAMP情報伝達系の関与2009
- Author(s)
  三嶋竜弥
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-19300133
[Presentation] Calcium loading capacity and morphological changes in mitochondria in an ischemic preconditioned model2009
- Author(s)
  Iijima T, Tanaka K, Matsubara S, Hayato K, Mishima T, Suga K, Akagawa K, Iwao K
- Organizer
  “Mitochondria Dynamics and Physiology" Keystone symposia
- Place of Presentation
  ウィスラーカナダ
- Year and Date
  2009-03-24
- Data Source
  KAKENHI-PROJECT-19591818
[Presentation] Effects of 5-HT signaling on cultured hippocampal neurons of HPC-1/syntaxin1A knock-out mouse2008
- Author(s)
  小藤剛史, 藤原智徳, 三嶋竜弥, 赤川公朗
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19500327
[Presentation] Ca^<++> buffering capacity of mitochondria after oxygen glucose deprivation in hippocampal neuron2007
- Author(s)
  Tanaka K, Iijima T, Mishima T, Suga K, Akagawa K
- Organizer
  Annual meeting of American Society of Anesthesiologists
- Place of Presentation
  San Francisco
- Year and Date
  2007-10-13
- Data Source
  KAKENHI-PROJECT-19591818
[Presentation] cAMP signaling cascade is reduced in hippocampal LTP of HPC-1/synta xin1A knock-out mice2007
- Author(s)
  三嶋竜弥, 藤原智徳, 小藤剛史, 赤川公朗
- Organizer
  第30回日本神経科学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-09-12
- Data Source
  KAKENHI-PROJECT-19500327
[Presentation] Upregulation of ER-Goligi SNARE syntaxin5 by ER stress and its relation with beta APP processing
- Author(s)
  K.Suga, A.Saito, T.Mishima & K.Akagawa
- Organizer
  日本神経化学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-24300142

1. SUGA Kei (30306675)

# of Collaborated Projects: 6 results

# of Collaborated Products: 22 results
2. SAITOU Ayako (80424109)

# of Collaborated Projects: 5 results

# of Collaborated Products: 9 results
3. KOFUJI Takefumi (40365200)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
4. IIJIMA Takehiko (10193129)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
5. FUJIWARA Tomonori (90255399)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
6. AKAGAWA Kimio (80129303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
7. SANADA Masumi (70424108)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. NAKAYAMA Takahiro (90342823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Mishima Tatsuya 三嶋 竜弥

三嶋 竜弥 ミシマ タツヤ

MISHIMA Tatsuya 三嶋 竜弥

三嶋 竜哉 ミシマ タツヤ

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低出力パルス超音波による神経活動抑制効果の作用機序の解明とてんかん治療への応用Principal Investigator

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Involvement of astrocytes in the development of febrile seizures due to STX1B haploinsufficiencyPrincipal Investigator

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Functional role of syntaxin 1B in the regulation of synaptic vesicle exocytosis and of the readily releasable pool at central synapsesPrincipal Investigator

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[Journal Article] Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes2024

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[Journal Article] Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.2017

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Mishima Tatsuya 三嶋竜弥

三嶋竜弥ミシマタツヤ

MISHIMA Tatsuya 三嶋竜弥

三嶋竜哉ミシマタツヤ