MORIGUCHI Tetsuo 森口徹生

Researcher Number	40323571
Other IDs
Affiliation (based on the past Project Information) *help	2010: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, プロテオ医学研究センター, 助教 2009: 東京医科歯科大学, 難治疾患研究所, COE拠点形成特任教員 2009: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 生物学部, 主任研究官 2008: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 生物学部, 主任研究官 2005 – 2007: 東京医科歯科大学, 難治疾患研究所, COE拠点形成特任教員 … More 2005 – 2006: 東京医科歯科大学, 難治疾患研究所・COE拠点形成特任研究員 2004: 東京医科歯科大学, 難治疾患研究所, COE教員 2003: 東京大学, 分子細胞生物学研究所, 助手 Less
Review Section/Research Field	Principal Investigator Cell biology / Pathological medical chemistry / General medical chemistry Except Principal Investigator Biological Sciences
Keywords	Principal Investigator シグナル伝達 / WNK / 初期発生 / がん / 発生 / 疾患 / WNK1 / OSR1 / SPAK / プロテインキナーゼ … More / 偽性低アルドステロン症II型 / 高血圧 / proprotein convertase / タンパク質切断 / Gタンパク質共役型受容体 … More Except Principal Investigator NKCC2 / NCC / Na^+-Cl^-共輸送体 / PHAII / OSR1 / SPAK / WNK1 / 高血圧症 / タンパク分解 / E3リガーゼ / E2-25K / LEF / TCF / Wntシグナル / TGF-βシグナル / Mo / アフリカツメガエル / 結合因子 / 頭部形成 / ユビキチン化 / リン酸化 / MEF2A / p38 / NARF / シグナル / NLK Less

The identification of signal components and analysis of the regulatory mechanisms of WNK protein kinases, the essential genes for early development and pathogenesis of hereditary form of hypertensionPrincipal Investigator
- Principal Investigator
  
  MORIGUCHI Tetsuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
Regulation of DECODE system in Development
- Principal Investigator
  
  SHIBUYA Hiroshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
PHAIIの原因遺伝子WNK1プロテインキナーゼの機能解析Principal Investigator
- Principal Investigator
  
  森口徹生
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Medical and Dental University
長鎖細胞外領域を有する新規Secretin様受容体の機能解析Principal Investigator
- Principal Investigator
  
  森口徹生
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Medical and Dental University
  The University of Tokyo

All 2011 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] 阻害剤活用ハンドブック2006
- Author(s)
  森口徹生
- Total Pages
  12
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17790205
[Journal Article] Involvement of LKB1 in Epithelial-Mesenchymal Transition (EMT) of Human Lung Cancer Cells2011
- Author(s)
  Roy BC, Kohno T, Iwakawa R, Moriguchi T, Kiyono T, Morishita K, Sanchez-Cespedes M, Akiyama T, Yokota J
- Journal Title
  
  Lung Cancer vol. 70
  
  Pages: 136-145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570179
[Journal Article] C. elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.2008
- Author(s)
  Hisamoto, N., Moriguchi, T., Urushiyama, S., Mitani, S., Shibuya, H., Matsumoto, K.
- Journal Title
  
  E M B O R e p. 9
  
  Pages: 70-75
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4D561A/+ knock-in mouse model.2007
- Author(s)
  Yang, S. -S., Morimoto, T., Rai, T., Chiga, M., Sohara, E., Ohno, M., Uchida, K., Lin, S. -H., Moriguchi, T., Shibuya, H., Kondo, Y., Sasaki, S., Uchida, S.
- Journal Title
  
  Cell Metabolism 5
  
  Pages: 331-344
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.2005
- Author(s)
  森口徹生, 他7名
- Journal Title
  
  The Journal of Biological Chemistry 280・52
  
  Pages: 42685-42693
- Data Source
  KAKENHI-PROJECT-17790205
[Journal Article] WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.2005
- Author(s)
  Moriguchi, T., Urushiyama, S., Hisamoto, N., Iemura, S., Uchida, S., Natsume, T., Matsumoto, K., Shibuya, H.
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 42685-42693
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.2005
- Author(s)
  Moriguchi et al.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 42685-42693
- Data Source
  KAKENHI-PROJECT-17054013
[Journal Article] Developmentally Regulated G protein-coupled receptor containing two conserved2004
- Author(s)
  森口徹生
- Journal Title
  
  Genes Cells 9・6
  
  Pages: 549-560
- Data Source
  KAKENHI-PROJECT-15790145
[Presentation] Involvement of LKB1 in epithelial-mesenchymal transition (EMT) of human lung cancer cells2009
- Author(s)
  森口徹生
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20570179
[Presentation] Involvement of LKB1 in Epithelial-Mesenchymal Transition(EMT)in Human Lung Cancer2009
- Author(s)
  森口徹生
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-20570179
[Presentation] KRAS/LKB1変異による肺腺がん細胞のEMTとがん幹細胞マーカーの発現誘導2009
- Author(s)
  森口徹生
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20570179
[Presentation] KRAS/LKB1変異による肺線がん細胞のEMTとがん幹細胞マーカーの発現誘導2009
- Author(s)
  森口徹生
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-20570179
[Presentation] LKB1 inactivation triggers EMT through the induction of transcriptional repressor ZEB1 in human lung cancer2008
- Author(s)
  森口徹生, et al
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20570179
[Presentation] LKB1 inactivation triggers EMT through the induction of transcriptional repressor ZEB1 in human lung cancer2008
- Author(s)
  Roy, BC, 河野隆志, 岩川麗香, 森口徹生, 他4名
- Organizer
  BMB2008(第31回日本分子生物学会年会第81回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20570179
[Presentation] 線虫WNK, SPAKおよびCLCチャネルによる水分排出器官の形態制御2006
- Author(s)
  久本直毅、漆山誠一、森口徹生、伊藤健太郎、三谷昌平、澁谷浩司、松本邦弘
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Year and Date
  2006-12-09
- Data Source
  KAKENHI-PROJECT-17054013
[Presentation] 偽性低アルドステロン症2型の原因遺伝子WNK1プロテインキナーゼはSTE20様キナーゼを介してNa+-Cl-共輸送体のN末制御領域をリン酸化する。2005
- Author(s)
  森口徹生、漆山誠一、久本直毅、家村俊一郎、内田信一、夏目徹、松本邦弘、澁谷浩司
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2005-12-09
- Data Source
  KAKENHI-PROJECT-17054013

1. SHIBUYA Hiroshi (30261324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. OHNISHI Junji (40261276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. SATOH Kiyotoshi (50401386)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KIM Misun (70508332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MORIGUCHI Tetsuo 森口 徹生

Research Projects

Research Products

Co-Researchers

The identification of signal components and analysis of the regulatory mechanisms of WNK protein kinases, the essential genes for early development and pathogenesis of hereditary form of hypertensionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of DECODE system in Development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PHAIIの原因遺伝子WNK1プロテインキナーゼの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

長鎖細胞外領域を有する新規Secretin様受容体の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 阻害剤活用ハンドブック2006

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Involvement of LKB1 in Epithelial-Mesenchymal Transition (EMT) of Human Lung Cancer Cells2011

Author(s)

Journal Title

Data Source

[Journal Article] C. elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.2008

Author(s)

Journal Title

Data Source

[Journal Article] Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4D561A/+ knock-in mouse model.2007

Author(s)

Journal Title

Data Source

[Journal Article] WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.2005

Author(s)

Journal Title

Data Source

[Journal Article] WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.2005

Author(s)

Journal Title

Data Source

[Journal Article] WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.2005

Author(s)

Journal Title

Data Source

[Journal Article] Developmentally Regulated G protein-coupled receptor containing two conserved2004

Author(s)

Journal Title

Data Source

[Presentation] Involvement of LKB1 in epithelial-mesenchymal transition (EMT) of human lung cancer cells2009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Involvement of LKB1 in Epithelial-Mesenchymal Transition(EMT)in Human Lung Cancer2009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] KRAS/LKB1変異による肺腺がん細胞のEMTとがん幹細胞マーカーの発現誘導2009

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] KRAS/LKB1変異による肺線がん細胞のEMTとがん幹細胞マーカーの発現誘導2009

MORIGUCHI Tetsuo 森口徹生