KUBOTA Toru 久保田徹

Researcher Number	40325444
Affiliation (based on the past Project Information) *help	2006: 九大, 医学(系)研究科(研究院), 助手 2001 – 2004: 九州大学, 大学院・医学研究院, 助手 2000 – 2001: 九州大学, 医学研究院, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine
Keywords	Principal Investigator NF-κB / cytokine / heart failure / NF-kB / サイトカイン / 心不全 / genetically-engineered mice / angiotensin / cardiac hypertrophy / サイトカン … More / 遺伝子改変マウス / アンジオテンシン / 心筋肥大 / transgenic mice / reactive oxygen species / nitric oxide / 活性酵素種 / 酸化窒素 / トランスジェニックマウス / 活性酸素種 / 一酸化窒素 … More Except Principal Investigator DNA / Mitochondria / Oxidative stress / Heart failure / 活性酸素種 / ミトコンドリア / 心不全 / Myocyte / Cytokine / ROS / Electron transport complex / ミトコンドア / 酸化損傷 / 心筋細胞 / サイトカイン / 電子伝達系 / Free radicals / Remodeling / 抗酸化薬 / 酸化ストレス / リモデリング / 心筋梗塞 Less

腫瘍壊死因子受容体サブタイプに基づく心不全に対する新規サイトカイン療法の開発Principal Investigator
- Principal Investigator
  
  久保田徹
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Elucidating the role of NF-κB activation in the pathogenesis of heart failurePrincipal Investigator
- Principal Investigator
  
  KUBOTA Toru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY
Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure
- Principal Investigator
  
  TSUTSUI Hiroyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  HOKKAIDO UNIVERSITY
  Kyushu University
Elucidating the mechanism of heart failure using mouse model of dilated cardiomyopathyPrincipal Investigator
- Principal Investigator
  
  KUBOTA Toru
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kyushu University
Mechanisms of oxygen radical generation in the mitochondria from the failing hearts
- Principal Investigator
  
  TSUTSUI Hiroyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  KYUSHU UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES

All 2004 2003 2002 Other

All Journal Article

[Journal Article] Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice.2004
- Author(s)
  Shiomi T, Tsutsui H, Matsusaka H, Murakami K, Hayashidani S, Ikeuchi M, Wen J, Kubota T, Utsumi H, Takeshita A
- Journal Title
  
  Circulation 109
  
  Pages: 544-549
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Inhibition of TGF-β signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction.2004
- Author(s)
  Ikeuchi M, Tsutsui H, Shiomi T, Matsusaka H, Matsushima S, Wen J, Kubota T, Takeshita A
- Journal Title
  
  Card Res 64
  
  Pages: 526-535
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Streptozotocin-induced hyperglycemia exacerbates left ventricular remodeling and failure after experimental myocardial infarction.2003
- Author(s)
  Shiomi S, Tsutsui H, Ikeuchi M, Matsusaka H, Hayashidani S, Suematsu N, Wen J, Kubota T, Takeshita A
- Journal Title
  
  J Am Coll Cardiol 42
  
  Pages: 165-172
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Oxidative stress mediates tumor necrosis factor-α induced mitochondrial DNA damage and dysfunction in cardiac myocytes.2003
- Author(s)
  Suematsu N, Tsutsui H, Wen J, Kang D, Ikeuchi M, Ide T, Hayashidani S, Shiomi T, Kubota T, Hamasaki N, Takeshita A
- Journal Title
  
  Circulation 107
  
  Pages: 1418-1423
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Targeted deletion of matrix metalloproteinase-2 attenuates early left ventricular rupture and late remodeling after experimental myocardial infarction2003
- Author(s)
  Hayashidani S, Tsutsui H, Ikeuchi M, Shiomi T, Matsusaka H, Kubota T, Imanaka-Yoshida K, Itoh T, Takeshita A
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.2003
- Author(s)
  Machida Y, Kubota T, Kawamura N, Funakoshi H, Ide T, Utsumi H, Li YY, Feldman AM, Tsutsui H, Shimokawa H, Takeshita A.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Pioglitazone, peroxisome proliferator-activated receptor γ agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction2002
- Author(s)
  Shiomi T, Tsutsui H, Hayashidani S, Suematsu N, Ikeuchi M, Wen J, Ishibashi M, Kubota T, Egashira K, Takeshita A
- Journal Title
  
  Circulation 106
  
  Pages: 3126-3132
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Disruption of inducible nitric oxide synthase improves beta-adrenergic isotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy.2002
- Author(s)
  Funakoshi H, Kubota T, Kawamura N, Machida Y, Feldman AM, Tsutsui H, Shimokawa H, Takeshita A
- Journal Title
  
  Circ Res 90
  
  Pages: 959-965
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370230
[Journal Article] Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II.
- Author(s)
  Kawano S, Kubota T, Monden Y, Kawamura N, Tsutsui H, Takeshita A, Sunagawa K.
- Journal Title
  
  Cardiovascular Research (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590755
[Journal Article] Blockade of NF-_κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy
- Author(s)
  Kawamura N, Kubota T, Kawano S, Monden Y, Feldman AM, Tsutsui H, Takeshita A, Sunagawa K.
- Journal Title
  
  Cardiovasc Res (in press)
- Data Source
  KAKENHI-PROJECT-15590755
[Journal Article] Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II.
- Author(s)
  Kawano S, Kubota T, Monden Y, Kawamura N, Tsutsui H, Takeshita A, Sunagawa K.
- Journal Title
  
  Cardiovasc Res (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590755
[Journal Article] Blockade of NF-κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy
- Author(s)
  Kawamura N, Kubota T, Kawano S, Monden Y, Feldman AM, Tsutsui H, Takeshita A, Sunagawa K.
- Journal Title
  
  Cardiovasc Res (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590755
[Journal Article] Blockade of NF-κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy
- Author(s)
  Kawamura N, Kubota T, Kawano S, Monden Y, Feldman AM, Tsutsui H, Takeshita A, Sunagawa K.
- Journal Title
  
  Cardiovascular Research (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590755

1. TSUTSUI Hiroyuki (70264017)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. UTSUMI Hideo (20101694)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. KANG Dongchong (80214716)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. ICHIKI Toshihiro (80311843)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KASAI Hiroshi (40152615)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIMOKAWA Hiroaki (00235681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 中別府雄作 (30180350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TADA Hideo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KUBOTA Toru 久保田 徹

Research Projects

Research Products

Co-Researchers

腫瘍壊死因子受容体サブタイプに基づく心不全に対する新規サイトカイン療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating the role of NF-κB activation in the pathogenesis of heart failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating the mechanism of heart failure using mouse model of dilated cardiomyopathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanisms of oxygen radical generation in the mitochondria from the failing hearts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Inhibition of TGF-β signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction.2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Streptozotocin-induced hyperglycemia exacerbates left ventricular remodeling and failure after experimental myocardial infarction.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Oxidative stress mediates tumor necrosis factor-α induced mitochondrial DNA damage and dysfunction in cardiac myocytes.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Targeted deletion of matrix metalloproteinase-2 attenuates early left ventricular rupture and late remodeling after experimental myocardial infarction2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Pioglitazone, peroxisome proliferator-activated receptor γ agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction2002

Author(s)

Journal Title

Description

Data Source

[Journal Article] Disruption of inducible nitric oxide synthase improves beta-adrenergic isotropic responsiveness but not the survival of mice with cytokine-induced cardiomyopathy.2002

Author(s)

Journal Title

Description

Data Source

[Journal Article] Blockade of NF-κB ameliorates myocardial hypertrophy in response to chronic infusion of angiotensin II.

Author(s)

Journal Title

Description

Data Source

[Journal Article] Blockade of NF-_κB improves cardiac function and survival without affecting inflammation in TNF-α-induced cardiomyopathy

KUBOTA Toru 久保田徹