Yamada Takeshi 山田武司

Researcher Number	40333554
Other IDs
Affiliation (Current)	2025: 愛媛県立医療技術大学, 保健科学部, 教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 愛媛県立医療技術大学, 保健科学部, 教授 2016 – 2017: 愛媛大学, 医学系研究科, 准教授 2014 – 2015: 愛媛大学, 医学(系)研究科(研究院), 准教授
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Immunology Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator CD8 / T細胞 / 抗腫瘍活性 / エピジェネティック調節 / CD8 T細胞 / エピジェネティック制御 / エピジェネティック / 抗腫瘍免疫 / ヒストン脱メチル化 / CD8+T細胞 … More / 感染免疫 / Utx / メモリー分化 / メモリー / 感染症 / 免疫 / 細胞疲弊 / T細胞の疲弊 / CD8陽性T細胞 / エネルギー代謝 / エフェクター維持 / Menin / 慢性型感染症 / T細胞疲弊 … More Except Principal Investigator Siglec-15 / 1本鎖抗体 / がん免疫療法 / 免疫チェックポイント / CAR-T細胞 / 抗腫瘍活性 / 小胞体ストレス / Ern1 / CD8 Less

小胞体ストレス応答蛋白 IRE1αに焦点を当てたT細胞の抗腫瘍活性の増強
- Principal Investigator
  
  田野ゆづき
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ehime Prefectural University of Health Science
ヒストン脱メチル化酵素Phf2の制御を介したT細胞抗腫瘍免疫の増強Principal Investigator
- Principal Investigator
  
  山田武司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ehime Prefectural University of Health Science
Development of multifunctional CAR-T cell therapy using novel manufacturing technology of scFv
- Principal Investigator
  
  安川正貴
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Ehime Prefectural University of Health Science
Enhancement of antitumor activity by epigenetic regulation of tumor-specific T cellsPrincipal Investigator
- Principal Investigator
  
  Takeshi Yamada
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Ehime Prefectural University of Health Science
Analysis of the memory CD8 T-cell differentiaition via control of histone demethylationPrincipal Investigator
- Principal Investigator
  
  Yamada Takeshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Ehime Prefectural University of Health Science
  Ehime University
Investigation of the molecular mechanisms to control T-cell exhaustionPrincipal Investigator
- Principal Investigator
  
  Yamada Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Ehime University

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4+ T cells2024
- Author(s)
  Arakawa Yuya、Tano Yuzuki、Fujii Moe、Imai Yuuki、Norimatsu Yoshiaki、Yasukawa Masaki、Watanabe Mikio、Yamada Takeshi
- Journal Title
  
  Cytokine
  
  Volume: 175 Pages: 156506-156506
- DOI
  10.1016/j.cyto.2024.156506
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08462, KAKENHI-PROJECT-22K16349, KAKENHI-PROJECT-23K06747, KAKENHI-PROJECT-23K24462
[Journal Article] Reinforced antimyeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with bridging-BiTE2023
- Author(s)
  Konishi Tatsuya、Ochi Toshiki、Maruta Masaki、Tanimoto Kazushi、Miyazaki Yukihiro、Iwamoto Chika、Saitou Takashi、Imamura Takeshi、Yasukawa Masaki、Takenaka Katsuto
- Journal Title
  
  Blood
  
  Volume: 142 Issue: 21 Pages: 1789-1805
- DOI
  10.1182/blood.2022019082
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08462, KAKENHI-PROJECT-21K15569, KAKENHI-PROJECT-21H02949
[Journal Article] Enhancement of antitumor activity by epigenetic regulation of tumour-specific T cells.2021
- Author(s)
  Yamada T, Arakawa Y.
- Journal Title
  
  Impact
  
  Volume: 8 Issue: 8 Pages: 6-8
- DOI
  10.21820/23987073.2021.8.6
- Open Access
- Data Source
  KAKENHI-PROJECT-20K07680
[Journal Article] T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.2020
- Author(s)
  Toriyama K, Kuwahara M, Kondoh H, Mikawa T, Takemori N, Konishi A., Yorozuya T, Yamada T, Soga T., Shiraishi A, and Yamashita M.
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 1-13
- DOI
  10.1038/s42003-020-01122-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07680, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04948, KAKENHI-PROJECT-20H03504, KAKENHI-PROJECT-18K08409, KAKENHI-PROJECT-19K07887, KAKENHI-PROJECT-20K20658
[Journal Article] Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells2019
- Author(s)
  Yamada Takeshi、Nabe Shogo、Toriyama Koji、Suzuki Junpei、Inoue Kazuki、Imai Yuuki、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 202 Issue: 4 Pages: 1088-1098
- DOI
  10.4049/jimmunol.1801083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08887, KAKENHI-PUBLICLY-17H05794, KAKENHI-PROJECT-17H04086, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-17K15728, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-18H02839, KAKENHI-PROJECT-17K11484
[Journal Article] Reinforce the antitumor activity of CD8+ T cells via glutamine restriction2018
- Author(s)
  Nabe Shogo、Yamada Takeshi、Suzuki Junpei、Toriyama Koji、Yasuoka Toshiaki、Kuwahara Makoto、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 12 Pages: 3737-3750
- DOI
  10.1111/cas.13827
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08887, KAKENHI-PROJECT-18K08409, KAKENHI-PUBLICLY-17H05794, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H04086, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-17K15728, KAKENHI-PROJECT-17K16853, KAKENHI-PROJECT-18H02839
[Journal Article] The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation2018
- Author(s)
  Suzuki Junpei、Yamada Takeshi、Inoue Kazuki、Nabe Shogo、Kuwahara Makoto、Takemori Nobuaki、Takemori Ayako、Matsuda Seiji、Kanoh Makoto、Imai Yuuki、Yasukawa Masaki、Yamashita Masakatsu
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41467-018-05854-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08887, KAKENHI-PROJECT-18K08409, KAKENHI-PUBLICLY-17H05794, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H04086, KAKENHI-PROJECT-17K15728, KAKENHI-PROJECT-18H02839
[Journal Article] Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection2016
- Author(s)
  Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M, and Yamashita M.
- Journal Title
  
  Journal of Immunology
  
  Volume: 197 Issue: 10 Pages: 4079-4089
- DOI
  10.4049/jimmunol.1502295
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460579, KAKENHI-PROJECT-15K15155, KAKENHI-PROJECT-15K19133, KAKENHI-PROJECT-15K20149
[Journal Article] The transcriptional repressor Gfi1 plays a critical role in the development of NKT1- and NKT2-type iNKT cells2016
- Author(s)
  Yasuoka, T. Yasukawa M, et al.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 6 Pages: e0157395-e0157395
- DOI
  10.1371/journal.pone.0157395
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-26460579, KAKENHI-PROJECT-15K20149
[Journal Article] The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis2014
- Author(s)
  Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., Nakayama, T., Yamashita, M
- Journal Title
  
  Nature Comm
  
  Volume: 5 Issue: 1 Pages: 3555-3555
- DOI
  10.1038/ncomms4555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-23390075, KAKENHI-PROJECT-24659475, KAKENHI-PUBLICLY-25118718, KAKENHI-PROJECT-25670232, KAKENHI-PROJECT-25860376, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-26293069, KAKENHI-PROJECT-26460579
[Presentation] Glutamine-dependent metabolic reprograming controls the signal transduction and differentiation od CD8 T cells.2019
- Author(s)
  Toriyama K, Kuwahara M, Nomura S, Yamada T, Shiraishi A, and Yamashita M.
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K08887
[Presentation] Utx negatively controls the memory formation of Ag-stimulated CD8+ T cells.2019
- Author(s)
  Yamada T, Suzuki J, Arakawa Y, Toriyama K, Shiraishi A, Imai Y, Yasukawa M, and Yamashita M.
- Organizer
  第48回日本免疫学会
- Data Source
  KAKENHI-PROJECT-17K08887
[Presentation] The tumor suppressor menin determines activated CD8 T cell fate by targeting mTORC1-dependent metabolic activation2018
- Author(s)
  Suzuki J, Kuwahara M, Yamada T, Yasukawa M, and Yamashita M.
- Organizer
  The 47th Annual Meeting of the Japanese Society of Immunology
- Data Source
  KAKENHI-PROJECT-17K08887
[Presentation] T細胞のエネルギー代謝制御と免疫応答2018
- Author(s)
  山田武司
- Organizer
  第26回分子寄生虫フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08887
[Presentation] グルタミン代謝抑制によるCD8+ T細胞の抗腫瘍活性増強メカニズム2018
- Author(s)
  名部省吾、山田武司、鈴木淳平、安川正貴
- Organizer
  第22回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-17K08887
[Presentation] Histone H3K27 demethylase negatively controls memory formation of Ag-stimulated CD8+ T cells2017
- Author(s)
  Takeshi Yamada, Koji Toriyama, Shogo Nabe, Makoto Kanoh, Yuuki Imai, Hiroaki Honda, and Masaki Yasukawa, Masakatsu Yamashita
- Organizer
  Kyoto T cell coference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08887
[Presentation] Restricted glutamine metabolism enhances anti-tumor activity of CD8+ T cells2017
- Author(s)
  Shogo Nabe, Takeshi Yamada, Junpei Suzuki, Masakatsu Yamashita, and Masaki Yasukawa
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-17K08887
[Presentation] Histone H3K27 demethylase negatively controls memory formation of Ag-stimulated CD8+ T cells.2017
- Author(s)
  Yamada Takeshi
- Organizer
  7th International Workshop Kyoto T cell conference
- Place of Presentation
  京都大学芝蘭会館
- Year and Date
  2017-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460579
[Presentation] 細胞内グルタミン代謝制御によるCD8+ T細胞の抗腫瘍活性増強効果2017
- Author(s)
  名部彰悟, 山田武司, 鈴木淳平, 山下政克, 安川正貴
- Organizer
  日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-17K08887
[Presentation] Menin plays a critical role in the survival of antigen-specific activated CD8+ T cells2015
- Author(s)
  山田武司
- Organizer
  日本免疫学会
- Place of Presentation
  札幌コンベンションセンター、北海道札幌市
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26460579
[Presentation] Menin plays a critical role in the expansion and maintenance of antigen-specific CD8+ T cells upon infection.
- Author(s)
  山田武司
- Organizer
  日本免疫学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26460579

1. 田野ゆづき (90983809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 安川正貴 (60127917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 越智俊元 (10571086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 黒崎知博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamada Takeshi 山田 武司

Research Projects

Research Products

Co-Researchers

小胞体ストレス応答蛋白 IRE1αに焦点を当てたT細胞の抗腫瘍活性の増強

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒストン脱メチル化酵素Phf2の制御を介したT細胞抗腫瘍免疫の増強Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of multifunctional CAR-T cell therapy using novel manufacturing technology of scFv

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Enhancement of antitumor activity by epigenetic regulation of tumor-specific T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the memory CD8 T-cell differentiaition via control of histone demethylationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the molecular mechanisms to control T-cell exhaustionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4+ T cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reinforced antimyeloma therapy via dual-lymphoid activation mediated by a panel of antibodies armed with bridging-BiTE2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhancement of antitumor activity by epigenetic regulation of tumour-specific T cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reinforce the antitumor activity of CD8+ T cells via glutamine restriction2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection2016

Author(s)

Journal Title

DOI

Data Source

Yamada Takeshi 山田武司