Yoshikawa Kiyotsugu 吉川清次

… Alternative Names

YOSHIKAWA Kiyotsugu 吉川清次

吉川清次ヨシカワキヨツグ

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Researcher Number	40333562
Other IDs
Affiliation (Current)	2025: 関西医科大学, 医学部, 研究員 2025: 同志社女子大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2023: 同志社女子大学, 薬学部, 教授 2018 – 2020: 長浜バイオ大学, バイオサイエンス学部, 教授 2016: 関西医科大学, 医学部, 研究員 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2012 – 2013: 京都大学, 医学(系)研究科(研究院), 准教授 2004: 京大, 助手 2003: 京都大学, 放射性同位元素総合センター, 助手
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / General surgery / Tumor biology / General medical chemistry
Keywords	Principal Investigator トリプルネガティブ乳癌 / 細胞運命制御 / 脂肪分化誘導 / 間葉上皮転換 / メタボローム / 脂肪分化 / 上皮間葉転換 / 間葉転換解除 / レポーター / MET … More / EMT / 短鎖RNA / 上皮化誘導 / 間葉転換 / スプライシング / 細胞運命制御因子 / 白血病 / 間葉系腫瘍 / 多系統分化 / CD36 / メタボローム解析 / 上皮化誘導shRNA / miR-200 / 膠芽腫 / ライブラリースクリーニング / 乳癌 / 間葉上皮転換 (MET) / 上皮間葉転換 (EMT) / 発現クローニング / 乳癌幹細胞 / AID / 体細胞突然変異 Less

Research Projects
(5 results)
Research Products
(26 results)

上皮化誘導・DNA修復抑制性短鎖RNAと細胞運命制御による難治性癌治療法の創出Principal Investigator
- Principal Investigator
  
  吉川清次
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Doshisha Women's College of Liberal Arts
Development of therapeutic strategy targeting epithelial-mesenchymal transition and cell-fate determination factor for malignancyPrincipal Investigator
- Principal Investigator
  
  Yoshikawa Kiyotsugu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Doshisha Women's College of Liberal Arts
  Nagahama Institute of Bio-Science and Technology
Establishment of luminal induction therapy of triple-negative breast cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Yoshikawa Kiyotsugu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Kansai Medical University
  Kyoto University
Application of sensitive EMT/MET reporter to identification of target genes for breast cancer stem cells.Principal Investigator
- Principal Investigator
  
  YOSHIKAWA Kiyotsugu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Kyoto University
AIDによる免疫グロブリン遺伝子体細胞突然変異導入のメカニズムの解明Principal Investigator
- Principal Investigator
  
  吉川清次
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2016 2015 2013 2012

All Journal Article Presentation

[Journal Article] Newly developed preclinical models reveal broad‐spectrum CDK inhibitors as potent drugs for CRPC exhibiting primary resistance to enzalutamide2023
- Author(s)
  Matsuoka Takashi、Sugiyama Aiko、Miyawaki Yoshifumi、Hidaka Yusuke、Okuno Yukiko、Sakai Hiroaki、Tanaka Hiroki、Yoshikawa Kiyotsugu、Fukui Tomohiro、Mizuno Kei、Sumiyoshi Takayuki、Goto Takayuki、Inoue Takahiro、Akamatsu Shusuke、Kobayashi Takashi、Nakamura Eijiro
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 1 Pages: 283-297
- DOI
  10.1111/cas.15984
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07290
[Journal Article] Role of Cancer Stem-like Cells in the Process of Invasion and Mesenchymal Transformation by a Reconstituted Triple-negative Breast Cancer Cell Population Resistant to p53-induced Apoptosis2022
- Author(s)
  Sana Inoue, Miki Imanishi, Ai Kanzaki, Atsumi Fujimoto, Marina Maeyama, Ayaka Okamoto, Hiroka Matsuda, Kiyotsugu Yoshikawa and Rei Takahashi
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 55 Issue: 5 Pages: 169-184
- DOI
  10.1267/ahc.22-00076
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2022-10-28
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07290
[Journal Article] Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity2016
- Author(s)
  Gongping Shi , Yoko Yoshida , Kanako Yuki , Tomomi Nishimura , Yukiko Kawata , Masahiro Kawashima , Keiko Iwaisako , Kiyotsugu Yoshikawa , Junichi Kurebayashi , Masakazu Toi
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 50 Pages: 82158-82169
- DOI
  10.18632/oncotarget.8620
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460390, KAKENHI-PROJECT-15K15473, KAKENHI-PROJECT-26461909
[Journal Article] Sal-like 4 (SALL4) is the factor for cell dispersion in basal-like breast cancer.2013
- Author(s)
  Itou, J., Matsumoto,Y., Yoshikawa,Y.and Toi,M
- Journal Title
  
  FEBS Letters
  
  Volume: 587 Pages: 3115-3115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650620
[Journal Article] Sal-like 4 (SALL4) is the factor for cell dispersion in basal-like breast cancer2013
- Author(s)
  Itou, J., Matsumoto,Y., Yoshikawa,Y.and Toi,M.
- Journal Title
  
  FEBS Letters
  
  Volume: 587 Pages: 3115-3121
- Data Source
  KAKENHI-PROJECT-24650620
[Presentation] 間葉系乳癌細胞における脂肪分化誘導の治療応用の可能性の探索2024
- Author(s)
  辻花愛那, 村井美翔, 磯本羽希菜, 柏木萌々子, 高橋玲, 吉川清次
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K07290
[Presentation] Identification of nucleic acid drug candidates against mesenchymal transition and its application to breast cancer and glioblastoma cells.2023
- Author(s)
  Kiyotsugu Yoshikawa, Rei Takahashi
- Organizer
  AACR-NCI-EORTC INTERNATIONAL CONFERENCE ON MOLECULAR TARGETS AND CANCER THERAPEUTICS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07290
[Presentation] 間葉系乳癌に対する脂肪分化療法の探索2023
- Author(s)
  吉川清次, 辻花愛那, 村井美翔, 磯本羽希菜, 柏木萌々子, 糸原奈央, 中江幹葉, 高橋玲
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07290
[Presentation] Molecular and metabolic target for epithelial-mesenchymal transition in human breast cancer and glioblastoma2022
- Author(s)
  Kiyotsugu Yoshikawa, Rei Takahashi
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K07290
[Presentation] Dynamic metabolic change during epithelial-mesenchymal transition in human mammary epithelial cells.2021
- Author(s)
  吉川清次
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07335
[Presentation] 間葉系乳癌細胞の分化制御療法の探求2020
- Author(s)
  吉川清次
- Organizer
  第18回日本乳癌学会近畿地方会
- Data Source
  KAKENHI-PROJECT-18K07335
[Presentation] 間葉転換解除による難治性がん治療法の開発2016
- Author(s)
  吉川清次、荒川芳輝、戸口田淳也、戸井雅和
- Organizer
  第７5回日本癌学会学術総会
- Place of Presentation
  横浜 (パシフィコ横浜)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K15473
[Presentation] トリプルネガティブ乳癌の間葉上皮転換による分化療法の検討：膠芽腫との比較から見えてきた治療可能性2016
- Author(s)
  吉川清次、戸井雅和
- Organizer
  第２４回日本乳癌学会学術総会
- Place of Presentation
  東京ビッグサイト（東京・江東区）
- Year and Date
  2016-06-17
- Invited
- Data Source
  KAKENHI-PROJECT-15K15473
[Presentation] トリプルネガティブ乳癌の間葉上皮転換による分化療法の検討：膠芽腫との比較から見えてきた治療可能性2016
- Author(s)
  吉川清次、戸井雅和
- Organizer
  第２４回日本乳癌学会学術総会
- Place of Presentation
  東京 (東京ビッグサイト)
- Year and Date
  2016-06-16
- Data Source
  KAKENHI-PROJECT-15K15473
[Presentation] Reversal of mesenchymal phenotype of triple-negative breast cancer and glioblastoma cells and its therapeutic implication.2015
- Author(s)
  Yoshikawa K, Sakai H, Shimazaki M, Okada N, Matsumoto Y, Reinherz E, Toi M.
- Organizer
  AACR-NCI-EORTC international conference
- Place of Presentation
  Boston (USA)
- Year and Date
  2015-11-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15473
[Presentation] 乳癌幹細胞特性と上皮間葉転換2015
- Author(s)
  吉川清次
- Organizer
  上方乳がん研究会
- Place of Presentation
  ホテルグランヴィア大阪（大阪・大阪）
- Year and Date
  2015-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-15K15473
[Presentation] トリプルネガティブ乳癌とグリオブラストーマにおけるMETによる分化療法の検討.2015
- Author(s)
  吉川清次、酒井浩旭、嶋崎雅広、岡田宣宏、松本純明、戸井雅和
- Organizer
  第５３回日本癌治療学会学術総会
- Place of Presentation
  国立京都国際会館 (京都・京都）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-15K15473
[Presentation] トリプルネガティブ乳癌とグリオブラストーマにおけるMETによる間葉転換解除による分化療法の検討.2015
- Author(s)
  吉川清次、酒井浩旭、嶋崎雅広、岡田宣宏、松本純明、戸井雅和
- Organizer
  第７４回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知・名古屋）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-15K15473
[Presentation] EMT/METレポーターを用いた網羅的乳癌幹細胞標的遺伝子の同定の試み2013
- Author(s)
  松本純明、伊東潤二、塩尻好恵、Ellis Reinherz, 戸井雅和、吉川清次
- Organizer
  第２１回日本乳癌学会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-24650620
[Presentation] EMT/METレポーターを用いた網羅的乳癌幹細胞標的遺伝子の同定の試み2013
- Author(s)
  松本純明、伊東潤二、塩尻好恵、Ellis Reinherz,戸井雅和、吉川清次
- Organizer
  第21回日本乳癌学会
- Place of Presentation
  浜松
- Data Source
  KAKENHI-PROJECT-24650620
[Presentation] Application of sensitive EMT reporter to identification of breast cancer stem cell-related genes.2013
- Author(s)
  Kiyotsugu Yoshikawa
- Organizer
  AACR meeting: tumor invasion and metastasis
- Place of Presentation
  アメリカ・サンディエゴ
- Data Source
  KAKENHI-PROJECT-24650620
[Presentation] Application of sensitive EMT reporter to identification of mammary stem cell-related genes2013
- Author(s)
  Yoshikawa,K., Matsumoto, Y., Ito, J., Shiojiri Y., Reinherz E., To M.
- Organizer
  AACR tumor invasion and metastasis meeting
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-24650620
[Presentation] Application of sensitive EMT reporter to identification of mammary stem cell-related genes.2012
- Author(s)
  Kiyotsugu Yoshikawa
- Organizer
  Gordon research conference
- Place of Presentation
  イタリア・ピザ
- Data Source
  KAKENHI-PROJECT-24650620
[Presentation] Application of sensitive EMT reporter to identification of mammary stem cell-related genes2012
- Author(s)
  Yoshikawa,K., Matsumoto, Y., Ito, J., Shiojiri Y., Reinherz E., To M.
- Organizer
  Gordon Research Conference, mammary gland biology
- Place of Presentation
  Barga, Italy
- Data Source
  KAKENHI-PROJECT-24650620
[Presentation] Application of sensitive EMT reporter to identification of mammary stem cell-related genes.2012
- Author(s)
  Kiyotsugu Yoshikawa
- Organizer
  Organisation for oncology and translational research 8th annual meeting
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-24650620
[Presentation] Application of sensitive epithelial-mesenchymal transition (EMT) reporter to identification of mammary stem cell-related genes2012
- Author(s)
  Yoshikawa K.
- Organizer
  OOTR 8^<th > anuual conference
- Data Source
  KAKENHI-PROJECT-24650620

Yoshikawa Kiyotsugu 吉川 清次

YOSHIKAWA Kiyotsugu 吉川 清次

吉川 清次 ヨシカワ キヨツグ

Research Projects

Research Products

上皮化誘導・DNA修復抑制性短鎖RNAと細胞運命制御による難治性癌治療法の創出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic strategy targeting epithelial-mesenchymal transition and cell-fate determination factor for malignancyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of luminal induction therapy of triple-negative breast cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Application of sensitive EMT/MET reporter to identification of target genes for breast cancer stem cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

AIDによる免疫グロブリン遺伝子体細胞突然変異導入のメカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Newly developed preclinical models reveal broad‐spectrum CDK inhibitors as potent drugs for CRPC exhibiting primary resistance to enzalutamide2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Cancer Stem-like Cells in the Process of Invasion and Mesenchymal Transformation by a Reconstituted Triple-negative Breast Cancer Cell Population Resistant to p53-induced Apoptosis2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sal-like 4 (SALL4) is the factor for cell dispersion in basal-like breast cancer.2013

Author(s)

Journal Title

Data Source

[Journal Article] Sal-like 4 (SALL4) is the factor for cell dispersion in basal-like breast cancer2013

Author(s)

Journal Title

Data Source

[Presentation] 間葉系乳癌細胞における脂肪分化誘導の治療応用の可能性の探索2024

Author(s)

Organizer

Data Source

[Presentation] Identification of nucleic acid drug candidates against mesenchymal transition and its application to breast cancer and glioblastoma cells.2023

Author(s)

Organizer

Data Source

[Presentation] 間葉系乳癌に対する脂肪分化療法の探索2023

Author(s)

Organizer

Data Source

[Presentation] Molecular and metabolic target for epithelial-mesenchymal transition in human breast cancer and glioblastoma2022

Author(s)

Organizer

Data Source

[Presentation] Dynamic metabolic change during epithelial-mesenchymal transition in human mammary epithelial cells.2021

Author(s)

Organizer

Yoshikawa Kiyotsugu 吉川清次

YOSHIKAWA Kiyotsugu 吉川清次

吉川清次ヨシカワキヨツグ