AIZAWA Tomoyasu 相沢智康

… Alternative Names

相澤智康アイザワトモヤス

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Researcher Number	40333596
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 先端生命科学研究院, 教授
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 先端生命科学研究院, 教授 2018 – 2021: 北海道大学, 先端生命科学研究院, 教授 2016: 北海道大学, 先端生命科学研究院, 准教授 2012 – 2015: 北海道大学, 先端生命科学研究科(研究院), 准教授 2014: 北海道大学, 先端生命科学研究院, 准教授 … More 2014: 北海道大学, 大学院理学研究科, 准教授 2012: 北海道大学, 先端生命科学研究院, 准教授 2011: 北海道大学, 大学院・先端生命科学研究院, 准教授 2009: 北海道大学, 大学院・理学研究科, 准教授 2007 – 2008: Hokkaido University, 大学院・先端生命科学研究院, 准教授 2007: 北海道大学, 大学院・理学研究科, 准教授 2006: Hokkaido Univ., Fac.Adv.Life Sci., Assoc.Prof., 大学院先端生命科学研究院, 助教授 2006: 北海道大学, 大学院理学研究科, 助手 2005: 北海道大学, 理学研究科, 助手 2002 – 2005: 北海道大学, 大学院・理学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Biophysics / Biological Sciences / Basic Section 43040:Biophysics-related / Basic Section 43020:Structural biochemistry-related / Science and Engineering / Biophysics Except Principal Investigator Animal physiology/Animal behavior / Science and Engineering / Basic Section 38050:Food sciences-related / Biophysics … More / Structural biochemistry / 動物生理・代謝 / Civil and environmental engineering / Biological Sciences Less
Keywords	Principal Investigator NMR / ペプチド / 立体構造 / サイトカイン / 抗菌 / 微生物 / Cry j 7 / Cup s 7 / BP14 / GRP … More / 果実 / 花粉 / アレルゲン / 酵母 / 大腸菌 / LPS / 遺伝子組換え / 抗菌ペプチド / 天然変性蛋白質 / DNA結合ドメイン / リピート配列 / 転写因子 / カイコ / 生体防御 / 構造生物学 / 受容体 / 初期免疫 / 立体構造解析 / タンパク質 / 蛋白質 / 細菌 / 感染症 / 相互作用 / 昆虫 … More Except Principal Investigator NMR / タンパク質 / サイトカイン / 昆虫 / 立体構造 / growth-blocking peptide / 自然免疫 / アポトーシス / protein / peptide / ペプチド / 血球 / 細胞膜タンパク質 / GBPレセプター / GBP / レセプター / チロシンリン酸化 / シグナル伝達 / 血球細胞 / キメラ / オレイン酸 / αラクトアルブミン / liver lipid accumulation / bile acids / 12α水酸化胆汁酸 / 脂肪肝 / 胆汁酸 / oleic acid / apoptosis / 脂肪酸 / invertebrate / conformational analysis / innate immune system / 生体防御 / 細胞成長因子 / 無脊椎動物 / 立体構造解析 / intracellular signal transduction / tyrosine phosphorylation / cell membrane protein / receptor / cytokine / insect / GBP(growth blocking peptide) / 血球活性化 / 細胞増殖 / 精製 / アフィニティークロマトグラフィー / GBP(growth-blocking peptide) / HighFive / アワヨトウ / 膜タンパク質 / growth-blocking peptide (GBP) / 細胞内情報伝達 / growth-blocking Peptide / 加水分解 / グライコブロッティング / 多糖類 / LPS / MALDI-TOF/MS / グライコブロッティング法 / MBR / 多糖 / ＭＢＲ / 膜ファウリング / ショウジョウバエ / 温度 / 抗菌ペプチド / Growth-blocking peptide (GBP) / プロセシング / セリン型プロテアーゼ / 非感染ストレス / サイトカン / 細胞性免疫 / 体液性免疫 / ストレス / Growth blocking peptide / growth-blocking peptide(GBP) / 細胞質カルシウム / 情報伝達 / インテグリン / GBP受容体アダプター / リゾチーム / ラクトアルブミン / 圧力変性 Less

スギ・ヒノキ由来ペプチドGRPによる花粉－食物アレルギー症候群発症の分子機構解析Principal Investigator
- Principal Investigator
  
  相沢智康
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Hokkaido University
Involvement of 12alpha-hydroxylated bile acids in the onset and aggravation of fatty liver
- Principal Investigator
  
  ISHIZUKA Satoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38050:Food sciences-related
- Research Institution
  Hokkaido University
Analysis of an allergen of cypress BP14 involved in pollen food associated syndromePrincipal Investigator
- Principal Investigator
  
  AIZAWA Tomoyasu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Hokkaido University
Structural change and interaction analysis of antimicrobial peptides in membrane conditionsPrincipal Investigator
- Principal Investigator
  
  AIZAWA TOMOYASU
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
Control of membrane fouling based on structures of polysaccharides revealed by application of glyco-blotting
- Principal Investigator
  
  KIMURA Katsuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Civil and environmental engineering
- Research Institution
  Hokkaido University
タンデムリピートを持つ新規天然変性ＤＮＡ結合ドメインの揺らぎと分子認識機構の解明Principal Investigator
- Principal Investigator
  
  相沢智康
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Insect growth-blocking peptide (GBP) signaling pathway mediates acute immune reactions during infectious and non-infectious stress
- Principal Investigator
  
  HAYAKAWA Yoichi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Saga University
Elucidation of molecular mechanisms of a multifunctional cytokine GBP in host defensePrincipal Investigator
- Principal Investigator
  
  AIZAWA Tomoyasu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
αラクトアルブミン構造中間体の形成と細胞結合機能
- Principal Investigator
  
  出村誠
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Analysis of GBP receptor structure and GBP signal transduction in hemocytes
- Principal Investigator
  
  HAYAKAWA Yoichi
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Saga University
自然免疫タンパク質と受容体タンパク質およびリポ多糖との相互作用
- Principal Investigator
  
  河野敬一
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
無脊椎動物由来自然免疫関連タンパク質の分子レベルでの異物認識と応答機構の解析Principal Investigator
- Principal Investigator
  
  相沢智康
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
リゾチーム・αラクトアルブミンの構造変換と細胞結合機能
- Principal Investigator
  
  出村誠, NITTA Katsutoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
Structural biological analysis of activation mechanism of hematocyte by ENF peptide family
- Principal Investigator
  
  KAWANO Keiichi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  HOKKAIDO UNIVERSITY
Development and structural characteristic of apoptosis-inducing α-lactalbumin
- Principal Investigator
  
  DEMURA Makoto
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
無脊椎動物由来生体防御タンパク質の分子レベルでの異物認識機構の解析Principal Investigator
- Principal Investigator
  
  相沢智康
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
多機能サイトカインGBPの受容体動作機構の解析Principal Investigator
- Principal Investigator
  
  相沢智康
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Hokkaido University
Demonstration of multiforms of insect cytokine receptors
- Principal Investigator
  
  HAYAKAWA Yoichi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  動物生理・代謝
- Research Institution
  Saga University
  Hokkaido University

[Journal Article] Gibberellin-regulated protein sensitization in Japanese cedar (Cryptomeria japonica) pollen allergic Japanese cohorts2021
- Author(s)
  Iizuka T, Takei M, Saito Y, Rumi F, Zheng J, Lu X, Chafey P, Broussard C, Guilloux-Assalet L, Charpin D, Ebisawa M, Senechal H, Aizawa T, Poncet P.
- Journal Title
  
  Allergy
  
  Volume: - Issue: 7 Pages: 14816-14816
- DOI
  10.1111/all.14816
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06074
[Journal Article] ホソイトスギ由来花粉関連食物アレルギー症候群原因抗原Cup s 7の解析2020
- Author(s)
  相沢智康
- Journal Title
  
  アレルギーの臨床
  
  Volume: 40 Pages: 150-153
- Data Source
  KAKENHI-PROJECT-18K06074
[Journal Article] The subtype of Cupressaceae pollinosis associated with Pru p 7 sensitization is characterized by a sensitization to a cross-reactive gibberellin-regulated protein in cypress pollen: BP14.2019
- Author(s)
  Poncet P, Aizawa T, Senechal H.
- Journal Title
  
  Clin Exp Allergy
  
  Volume: 49 Issue: 8 Pages: 1163-1166
- DOI
  10.1111/cea.13418
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06074
[Journal Article] Pollen/Fruit Syndrome: Clinical Relevance of the Cypress Pollen Allergenic Gibberellin-Regulated Protein.2019
- Author(s)
  Senechal H, Keykhosravi S, Couderc R, Selva MA, Shahali Y, Aizawa T, Busnel JM, Arif R, Mercier I, Pham-Thi N, Charpin DA, Poncet P.
- Journal Title
  
  Allergy Asthma Immunol Res
  
  Volume: 11 Issue: 1 Pages: 143-151
- DOI
  10.4168/aair.2019.11.1.143
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06074
[Journal Article] Overexpression of Antimicrobial, Anticancer, and Transmembrane Peptides in Escherichia coli through a Calmodulin-Peptide Fusion System.2017
- Author(s)
  Ishida H, Nguyen LT, Gopal R, Aizawa T, Vogel HJ.
- Journal Title
  
  J Am Chem Soc
  
  Volume: 138 Pages: 11318-26
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440072
[Journal Article] Lipopolysaccharide-bound structure of the antimicrobial peptide cecropin P1 determined by nuclear magnetic resonance spectroscopy.2016
- Author(s)
  Baek MH, Kamiya M, Kushibiki T, Nakazumi T, Tomisawa S, Abe C, Kumaki Y, Kikukawa T, Demura M, Kawano K, Aizawa T.
- Journal Title
  
  J Pept Sci.
  
  Volume: 22 Issue: 4 Pages: 214-221
- DOI
  10.1002/psc.2865
- NAID
  120005981524
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440072, KAKENHI-PROJECT-15K01805
[Journal Article] Expression, purification and characterization of the recombinant cysteine-rich antimicrobial peptide snakin-1 in Pichia pastoris.2016
- Author(s)
  Kuddus MR, Rumi F, Tsutsumi M, Takahashi R, Yamano M, Kamiya M, Kikukawa T, Demura M, Aizawa T.
- Journal Title
  
  Protein Expr Purif.
  
  Volume: 122 Pages: 15-22
- DOI
  10.1016/j.pep.2016.02.002
- NAID
  120006219912
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440072
[Journal Article] Efficient production of a correctly folded mouse α-defensin, cryptdin-4, by refolding during inclusion body solubilization.2015
- Author(s)
  Tomisawa S, Sato Y, Kamiya M, Kumaki Y, Kikukawa T, Kawano K, Demura M, Nakamura K, Ayabe T, Aizawa T.
- Journal Title
  
  Protein Expr Purif.
  
  Volume: 112 Pages: 21-28
- DOI
  10.1016/j.pep.2015.04.007
- NAID
  120005820696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01805, KAKENHI-PROJECT-26440072, KAKENHI-PROJECT-26462831
[Journal Article] Identification of proteins involved in membrane fouling in membrane bioreactors (MBRs) treating municipal wastewater2012
- Author(s)
  Miyoshi, T., Aizawa, T., Kimura, K., Watanabe, Y.
- Journal Title
  
  International Biodeterioration and Biodegradation
  
  Volume: 75 Pages: 15-22
- NAID
  120005228166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24360212
[Journal Article] The C-terminal elongation of Growth-blocking peptide enhances its biological activity and micelle binding affinity.2009
- Author(s)
  Umetsu, Y, Aizawa, T, Muto, K, Yamamoto, H, Kamiya, M, Kumaki, Y, Demura, M, Hayakawa, Y., Kawano, K.
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 29625-29634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370031
[Journal Article] A novel peptide mediates aggregation and migration of hemocytes from an insect.2009
- Author(s)
  Nakatogawa, S., Oda, Y., Kamiya, M., Kamijima, T., Aizawa, T., Clark, KD., Kawano, K., Strand, R.M., Hayakawa, Y.
- Journal Title
  
  Curr.Biol. 19
  
  Pages: 779-785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370031
[Journal Article] The C-terminal elongation of Growth-blocking peptide enhances its biological activity and micelle binding affinity.2009
- Author(s)
  Umetsu, Y, Aizawa, T, Muto, K, Yamamoto, H, Kamiya, M, Kumaki, Y, Demura, M, Hayakawa, Y., Kawano, K.
- Journal Title
  
  J. Biol. Chem. 284
  
  Pages: 29625-29634
- Data Source
  KAKENHI-PROJECT-18370031
[Journal Article] A novel peptide mediates aggregation and migration of hemocytes from an insect2009
- Author(s)
  Nakatogawa, S., Oda, Y., Kamiya, M., Aizawa, T., Kawano,K., Strand, R.M. and Hayakawa, Y.
- Journal Title
  
  Curr. Biol. (In press)
- Data Source
  KAKENHI-PROJECT-18370031
[Journal Article] A novel peptide mediates aggregation and migration of hemocytes from an insect.2009
- Author(s)
  Nakatogawa, S., Oda, Y., Kamiya, M., Kamijima, T., Aizawa, T., Clark, KD., Kawano, K., Strand, R.M., Hayakawa, Y.
- Journal Title
  
  Curr. Biol. 19
  
  Pages: 779-785
- Data Source
  KAKENHI-PROJECT-18370031
[Journal Article] The Structure of a Novel Insect Peptide Explains Its Ca(2+) Channel Blocking and Antifungal Activities2008
- Author(s)
  Kouno T, Mizuguchi M, Tanaka H, Yang P, Mori Y, Shinoda H, Unoki K, Aizawa T, Demura M, Suzuki K, Kawano K.
- Journal Title
  
  Biochemistry (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031002
[Journal Article] Structural Properties of the DNA-Bound Form of a Novel Tandem Repeat DNA-Binding Domain, STPR2008
- Author(s)
  S. Saito, T. Yokoyama, T. Aizawa, K. Kawaguchi, T. Yamaki, D. Matsumoto, M. Kamiya, Y. Kumaki, M. Mizuguchi, S. Takiya, M. Demura, K. Kawano
- Journal Title
  
  PROTEINS (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031002
[Journal Article] Spontaneous asparaginyl deamidation of canine milk lysozyme under mild conditions2008
- Author(s)
  Y. Nonaka, T. Aizawa, D. Akieda, M. Watanabe, N. Watanabe, I. Tanaka, M. Kamiya, M. Mizuguchi, K. Nitta, M. Demura, K. Kawano
- Journal Title
  
  PROTEINS (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031002
[Journal Article] Equilibrium and Kinetics of the Folding and Unfolding of Canine Milk Lysozyme2007
- Author(s)
  H. Nakatani, K. Maki, K. Saeki, T. Aizawa, M. Demura, K. Kawano, S. Tomoda, K. Kuwajima
- Journal Title
  
  Biochemistry 46
  
  Pages: 5238-5251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031002
[Journal Article] Structural approach to a novel tandem repeat DNA-binding domain, STPR, by CD and NMR2007
- Author(s)
  S. Saito, T. Aizawa, K. Kawaguchi, T. Yamaki, D. Matsumoto, M. Kamiya, Y. Kumaki, M. Mizuguchi, S. Takiya, M. Demura, and K. Kawano
- Journal Title
  
  Biochemistry 46
  
  Pages: 1703-1713
- Data Source
  KAKENHI-PROJECT-19770123
[Journal Article] The structure of a novel insect peptide explains its Ca2+ channel blocking and antifungal activities2007
- Author(s)
  T. Kouno, M. Mizuguchi, H. Tanaka, P. Yang, Y. Mori, H. Shinoda, K. Unoki, T. Aizawa, M. Demura, K. Suzuki, and K. Kawano
- Journal Title
  
  Biochemistry 46
  
  Pages: 13733-13741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770123
[Journal Article] Structural Approach to a Novel Tandem Repeat DNA-Binding Domain, STPR, by CD and NMR2007
- Author(s)
  S. Saito, T. Aizawa, K. Kawaguchi, T. Yamaki, D. Matsumoto, M. Kamiya, Y. Kumaki, M. Mizuguchi, S. Takiya, M. Demura, K. Kawano
- Journal Title
  
  Biochemistry 46
  
  Pages: 1703-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031002
[Journal Article] Destabilization of Transthyretin by Pathogenic Mutations in the DE loop2007
- Author(s)
  Takeuchi, M., Mizuguchi, M., Kouno, T., Shinohara, Y., Aizawa, T., Demura, M., Mori, Y., Shinoda H. and Kawano
- Journal Title
  
  PROTEINS 66
  
  Pages: 716-725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031002
[Journal Article] The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif2007
- Author(s)
  N. Fujitani, T. Kouno, T. Nakahara, K. Takaya, T. Osaki, S. Kawabata, M. Mizuguchi, T. Aizawa, M. Demura, S. Nishimura, and K. Kawano
- Journal Title
  
  J. Pept. Sci 13
  
  Pages: 269-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770123
[Journal Article] The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif2007
- Author(s)
  Fujitani N, Kouno T, Nakahara T, Takaya K, Osaki T, Kawabata S, Mizuguchi M, Aizawa T, Demura M, Nishimura S, Kawano K.
- Journal Title
  
  Pept. Sci. 13
  
  Pages: 269-279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18031002
[Journal Article] N-Terminal Mutational Analysis of the Interaction Between Growth-Blocking Peptide (GBP) and Receptor of Insect Immune Cells.2006
- Author(s)
  Watanabe, S., Tada, M., Aizawa, T., Yoshida, M., Sugaya, T., Taguchi, M., Kouno, T., Nakamura, T., Mizuguchi, M., Demura, M. Hayakawa, Y., Kawano, K.
- Journal Title
  
  Protein & Peptide Letters 13
  
  Pages: 815-822
- Data Source
  KAKENHI-PROJECT-18370031
[Journal Article] N-Terminal Mutational Analysis of the Interaction Between Growth-Blocking Peptide (GBP) and Receptor of Insect Immune Cells.2006
- Author(s)
  Watanabe, S., Tada, M., Aizawa, T., Yoshida, M., Sugaya, T., Taguchi, M., Kouno, T., Nakamura, T., Mizuguchi, M., Demura, M., Hayakawa, Y., Kawano, K.
- Journal Title
  
  Protein ＆ Peptide Letters 13
  
  Pages: 815-822
- Data Source
  KAKENHI-PROJECT-18370031
[Journal Article] Peptide mimics of epidermal growth factor (EGF) with antagonistic activity.2005
- Author(s)
  Nakamura, T., Takasugi, H., Aizawa, T., Yoshida, M., Mizuguchi, M., Mori, Y, Shinoda H., Hayakawa, Y., Kawano, K.
- Journal Title
  
  J.Biotechnol. 116
  
  Pages: 211-219
- Data Source
  KAKENHI-PROJECT-14340261
[Journal Article] A Non-Native alpha-Helix Is Formed in the beta-sheet Region of the Molten Globule State of Canine Milk Lysozyme2004
- Author(s)
  M.Watanabe, Y.Kobashigawa, T.Aizawa, M.Demura, K.Nitta
- Journal Title
  
  Protein J. 23
  
  Pages: 335-342
- Data Source
  KAKENHI-PROJECT-16570129
[Journal Article] Volumetric behavior of the molten globule state of canine milk lysozyme2004
- Author(s)
  M.Watanabe, Y.Kobashigawa, T.Aizawa, M.Demura, K.Nitta
- Journal Title
  
  Protein Pept Lett. 11
  
  Pages: 325-330
- Data Source
  KAKENHI-PROJECT-16570129
[Journal Article] The Gly-Gly Linker Region of the Insect Cytokine Growth Blocking Peptide (GBP) is Essential for Activity2004
- Author(s)
  Yoshida, M., Aizawa, T., Nakamura, T., Shitara, K., Hayakawa, Y.他9
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 51331-51337
- Data Source
  KAKENHI-PROJECT-14340261
[Journal Article] Effect of Hydrostatic Pressure on Conformational Changes of Canine Milk Lysozyme between the Native, Molten Globule, and Unfolded States2004
- Author(s)
  M.Watanabe, T.Aizawa, M.Demura, K.Nitta
- Journal Title
  
  Biochim.Biophys.Acta 1702
  
  Pages: 129-136
- Data Source
  KAKENHI-PROJECT-16570129
[Journal Article] The Gly-Gly Linker Region of Insect Cytokine Growth Blocking Peptide (GBP) is Essential for Activity2004
- Author(s)
  M.Yoshida, T.Aizawa, T.Nakamura, K.Shitara, Y.Hayakawa, K.Matsubara, K.Miura, T.Kouno, K.D.Clark, M.R.Strand, M.Mizuguchi, M.Demura, K.Nitta K.Kawano
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 51331-51337
- Data Source
  KAKENHI-PROJECT-16570129
[Journal Article] A novel peptide mediates aggregation and migration of hemocytes from an insect
- Author(s)
  S. Nakatogawa, Y. Oda, M. Kamiya, T. Kamijima, T. Aizawa, K. D. Clark, M. Demura, K. Kawano, M. R. Strand and Y. Hayakawa
- Journal Title
  
  Curr. Biol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19770123
[Patent] 毛乳頭細胞を活性化するためのサイトカイン2004
- Inventor(s)
  早川洋一, 相沢智康, 河野敬一, 多田雅人
- Industrial Property Rights Holder
  北海道大学学長
- Industrial Property Number
  2004-226985
- Filing Date
  2004-08-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14340261
[Presentation] Gene Identification Of An Allergen Peptide From Cypress Pollen Using Next Generation Sequencer And Its Over Expression For Analysis2020
- Author(s)
  Tomona Iizuka, Helene Senechal, Pascal Poncet, Tomoyasu Aizawa
- Organizer
  第20 回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06074
[Presentation] Expression, purification and characterization of the recombinant cysteine-rich antimicrobial peptide snakin-1 derived from potato2017
- Author(s)
  Megumi Yamano, MD Ruhul Kuddus, Farhana Rumi, Takashi Kikukawa, Hiroyuki Kumeta, Yasuhiro Kumaki, Masakatsu Kamiya, Takashi Kikukawa, Makoto Demura, Tomoyasu Aizawa
- Organizer
  The 2017 Annual Meeting of the Japan Society for Biosciene, Biotechnology
- Place of Presentation
  京都女子大学（京都府・京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] Mutation analysis of cryptdin-4, antimicrobial peptide from mouse2017
- Author(s)
  Rina HIRAMINE, Hiroyuki KUMETA, Yasuhiro KUMAKI, Takashi KIKUKAWA, Makoto DEMURA, Kiminori NAKAMURA, Tokiyoshi AYABE, Tomoyasu AIZAWA
- Organizer
  The 2017 Annual Meeting of the Japan Society for Biosciene, Biotechnology
- Place of Presentation
  京都女子大学（京都府・京都市）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] 抗菌ペプチドantibacterial factor-2（ABF-2）が持つ特徴的なC末端側領域の機能的役割2016
- Author(s)
  桑畑佳奈、神谷昌克、菊川峰志、出村誠、相沢智康
- Organizer
  日本生物物理学会北海道支部例会
- Place of Presentation
  北海道大学（北海道・札幌市）
- Year and Date
  2016-03-14
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] ジャガイモ由来抗菌ペプチドsnakin-1の安定的な発現・精製系の構築とNMRによる構造解析2016
- Author(s)
  山野めぐみ、神谷昌克、熊木康裕、菊川峰志、出村誠、相沢智康
- Organizer
  日本農芸化学会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] 組換え抗菌ペプチドの安定生産技術とその解析への利用2015
- Author(s)
  相沢智康
- Organizer
  第１５回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島県・徳島市）
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] NMRおよびドッキングによる抗菌ペプチドとリポ多糖の複合体構造解析2014
- Author(s)
  櫛引崇弘,　神谷昌克,　相沢智康,　熊木康裕,　菊川峰志,　水口峰之,　出村誠,　川畑俊一郎,　河野敬一
- Organizer
  日本生物物理学会第52回年会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] 再構成無細胞系を用いた短鎖ペプチドの直接発現2014
- Author(s)
  冨澤聡,　神谷昌克,　菊川峰志,　出村誠,　相沢智康
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜・横浜産貿ホール（神奈川県）
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] 抗菌ペプチドcecropin P1の大腸菌発現系における発現効率に影響を与える要因の解明2014
- Author(s)
  阿部千春,　中住太一,　神谷昌克,　菊川峰志,　河野敬一,　出村誠,　相沢智康
- Organizer
  日本生物物理学会第52回年会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] 再構成無細胞系を用いた抗菌ペプチドの直接発現2014
- Author(s)
  冨澤聡,　神谷昌克,　菊川峰志,　出村誠,　相沢智康
- Organizer
  日本生物物理学会第52回年会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] 抗菌ペプチド human defensin 5のNMRによる多量体形成機構の解析2014
- Author(s)
  橋本革,　冨澤聡,　神谷昌克,　菊川峰志,　熊木康裕,　中村公則,　綾部時芳,　相沢智康,　出村誠
- Organizer
  日本生物物理学会第52回年会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2014-09-27
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] Elucidation of influential factor for heterologous productivity of the antimicrobial peptide, cecropin P1 using Escherichia coli2014
- Author(s)
  Abe, C., Nakazumi, T., Beak, M., Kamiya, M., Kikukawa, T., Kawano, T., Demura, M. Aizawa, T.
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島大学（徳島市）
- Year and Date
  2014-10-22
- Data Source
  KAKENHI-PROJECT-26440072
[Presentation] Formation of alpha-lactalbumin-fatty acid complex as an apoptosis induction factor: Evaluation with chimeric proteins2008
- Author(s)
  T. Kamijima, T. Aizawa, M. Kamiya, K. Kawano, M. Demura
- Organizer
  水と生体分子ワークショップ
- Place of Presentation
  奈良
- Year and Date
  2008-01-24
- Data Source
  KAKENHI-PROJECT-18031002
[Presentation] 昆虫由来成長阻害因子Growth-blocking peptide(GBP)の寄生によるC 末端残基伸長が生体膜相互作用と活性に与える影響2008
- Author(s)
  梅津喜崇,相沢智康,武藤香織,山本宏子, 神谷昌克,熊木康裕,水口峰之,出村誠,早川洋一,河野敬一
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19770123
[Presentation] 成長阻害因子growth-blocking peptide(GBP)のC末端残基伸長部分による生体膜相互作用が立体構造と活性に与える影響2007
- Author(s)
  梅津喜崇,相沢智康,武藤香織,山本宏子, 神谷昌克,熊木康裕,水口峰之,出村誠,早川洋一, 河野敬一
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-19770123
[Presentation] 成長阻害因子GBPのC 末端残基伸長が構造と活性に与える影響2007
- Author(s)
  梅津喜崇,相沢智康,武藤香織,山本宏子, 神谷昌克,熊木康裕,水口峰之,出村誠,早川洋一,河野敬一
- Organizer
  第44回ペプチド討論会
- Place of Presentation
  富山国際会議場
- Data Source
  KAKENHI-PROJECT-19770123
[Presentation] イヌミルクリゾチームの物性解析に向けた安定化変異体の構築2007
- Author(s)
  野中康宏, 秋枝大介, 神谷昌克, 相沢智康, 出村誠, 河野敬
- Organizer
  日本生物物理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18031002

1. DEMURA Makoto (70188704)

# of Collaborated Projects: 7 results

# of Collaborated Products: 13 results
2. KAWANO Keiichi (10136492)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
3. HAYAKAWA Yoichi (50164926)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
4. NITTA Katsutoshi (80001858)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
5. MIZUGUCHI Mineyuki (30332662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIMADA Kimio (30001663)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KIMURA Katsuki (10292054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. HINOU Hiroshi (70333333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAWABATA Shun-ichiro (90183037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIZUKA Satoshi (00271627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 神谷昌克 (30399810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
12. MATSUMOTO Hitoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FURIHATA Shunsuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

AIZAWA Tomoyasu 相沢 智康

相澤 智康 アイザワ トモヤス

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Co-Researchers

スギ・ヒノキ由来ペプチドGRPによる花粉－食物アレルギー症候群発症の分子機構解析Principal Investigator

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Analysis of an allergen of cypress BP14 involved in pollen food associated syndromePrincipal Investigator

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Structural change and interaction analysis of antimicrobial peptides in membrane conditionsPrincipal Investigator

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タンデムリピートを持つ新規天然変性ＤＮＡ結合ドメインの揺らぎと分子認識機構の解明Principal Investigator

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Elucidation of molecular mechanisms of a multifunctional cytokine GBP in host defensePrincipal Investigator

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無脊椎動物由来自然免疫関連タンパク質の分子レベルでの異物認識と応答機構の解析Principal Investigator

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AIZAWA Tomoyasu 相沢智康

相澤智康アイザワトモヤス