NAGASHIMA TAKASHI 長島隆

… Alternative Names

長島隆ナガシマタカシ

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Researcher Number	40338116
Other IDs
Affiliation (based on the past Project Information) *help	2018: 杏林大学, 医学部, 非常勤講師 2017: 慶應義塾大学, 医学部, 共同研究員 2015 – 2017: 杏林大学, 医学部, 講師 2016: 慶應義塾大学, 医学部(信濃町), 共同研究員 2014 – 2015: 慶應義塾大学, 医学部, 共同研究員 2007 – 2008: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology
Keywords	Principal Investigator BMP7 / BMP4 / BMPR2 / 常位胎盤早期剥離 / 遺伝子制御ベクター / 疾患モデルマウス / 胎盤早期剥離 / 生殖医学 / 産婦人科学 / 血管新生 … More / 妊孕性低下 / 脱落膜化 / ノックアウトマウス / 子宮特異的 / 核磁気共鳴法 / リガンド … More Except Principal Investigator NK細胞 / T細胞 / マクロファージ / Tリンパ球 / 生殖免疫 / 着床 / 妊娠 / メチレンテトラ葉酸還元酵素 / 不育症 / プレコンセプションケア / 耐糖能異常 / ホモシステイン / テトラメチレンヒドロ葉酸代謝還元酵素 / ビタミンD / セクレトーム / 体外受精 / プロテオミクス / 胚 / マウス Less

Trial for Innovative Therapy against Placental Abruption by Using Model MousePrincipal Investigator
- Principal Investigator
  
  NAGASHIMA TAKASHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyorin University
The immune regulatory activated by Vitamin D has been the novel treatment for recurrent implantation failure and recurrent pregnancy losses
- Principal Investigator
  
  Ota Kuniaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University
Analyses of pathologic conditions and development of innovative medical care for placental abruption by using NMR methodPrincipal Investigator
- Principal Investigator
  
  NAGASHIMA TAKASHI
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyorin University
  Keio University
分泌蛋白プロファイリング(secretome)によるマウス初期胚の機能評価
- Principal Investigator
  
  Maruyama Tetsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University

All 2018 2015 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling.2015
- Author(s)
  Ono M, Kajitani T, Uchida H, Arase T, Oda H, Uchida S, Ota K, Nagashima T, Masuda H, Miyazaki K, Asada H, Hida N, Mabuchi Y, Morikawa S, Ito M, Bulun SE, Okano H, Matsuzaki Y, Yoshimura Y, Maruyama T
- Journal Title
  
  Biol Reprod
  
  Volume: 93巻 Issue: 2 Pages: 1-9
- DOI
  10.1095/biolreprod.114.127126
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10685, KAKENHI-PROJECT-15K15610, KAKENHI-PROJECT-25462574, KAKENHI-PROJECT-25463226, KAKENHI-PROJECT-25670181, KAKENHI-PROJECT-26861340
[Journal Article] The UDP-glucose receptor P2RY14 triggers innate mucosalimmunity in the female reproductive tract by inducing IL-8.2009
- Author(s)
  Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
- Journal Title
  
  The Journal of Immunology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] Analysis of serum FSH bioactivity in a patient with an FSH-secreting pituitary microadenoma and multicystic ovaries : A case report.2008
- Author(s)
  Kajitani T, Liu S, Maruyama T, Uchida H, Sakurai R, Masuda H, Nagashima T, Ono M, Arase T, Yoshimura Y
- Journal Title
  
  Human reproduction (Oxford, England) 23
  
  Pages: 435-439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] 【子宮内膜の機能と生殖医療その最前線】子宮内膜脱落膜化の機序の解明チロシンキナーゼSRCの役割と意義2008
- Author(s)
  丸山哲夫, 長島隆, 梶谷宇, 内田浩, 吉村泰典
- Journal Title
  
  産婦人科の実際 57
  
  Pages: 193-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells.2008
- Author(s)
  Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Asada H, Yoshimura Y
- Journal Title
  
  Endocrinology 149
  
  Pages: 1227-1234
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss.2008
- Author(s)
  Ozawa N, Maruyama T, Nagashima T, Ono M, Arase T, Ishimoto H, Yoshimura Y
- Journal Title
  
  Fertil Steril 90
  
  Pages: 1301-1304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] 妊娠子宮における子宮筋Side Population細胞の役割.2008
- Author(s)
  小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 各務真紀, 小田英之, 西川明花, 升田博隆, 長島隆, 太田邦明, 伊藤守, 浅田弘法, 岡野栄之, 松崎有未, 吉村泰典
- Journal Title
  
  日本生殖内分泌学会雑誌 13
  
  Pages: 25-29
- NAID
  10021262312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] Glycodelin blocks progression to S phase and inhibits cell growth : a possible progesterone-induced regulator for endometrial epithelial cell growth.2008
- Author(s)
  Ohta K, Maruyama T, Uchida H, Ono M, Nagashima T, Arase T, Kajitani T, Oda H, Morita M, Yoshimura Y
- Journal Title
  
  Molecular human reproduction 14
  
  Pages: 17-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] 着床期特異的蛋白glycodelinによる子宮内膜腺上皮細胞の増殖機能制御.2008
- Author(s)
  太田邦明, 丸山哲夫, 内田浩, 小野政徳, 荒瀬透, 長島隆, 青木大輔, 森田峰人, 吉村泰典
- Journal Title
  
  日本生殖内分泌学会雑誌 13
  
  Pages: 43-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] Side population in human uterine myometrium displays phenotypic and functional chafacteristics of myometrial stem cells2007
- Author(s)
  Ono M, Maruyama T^*, Masuda H, Kajitani T, Nagashima T, Arase T, Ito M, Ohta K, Uchida H, Asada H, Yoshimura Y, Okano H, Matsuzaki Y
- Journal Title
  
  Proc Natl Acad Sci USA 104
  
  Pages: 18700-18705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] Histone deacetylase inhibitors stimulate cell migration in human endometdalMol Hum Reprod.adenocarcinoma cells through up-regulation of glycodelin2007
- Author(s)
  Uchida H, Maruyama T^*, Ono M, Ohta K, Kajitani T, Masuda H, Nagashima T, Arase T, Asada H, Yoshixnura Y
- Journal Title
  
  Endocrinology 148
  
  Pages: 896-902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis2007
- Author(s)
  Nagashima T, Maruyama T^*, Furuya M, Kajitani T, Uchida H, Masuda H, Ono M, Arase T, Ozato K, Yoshimura Y
- Journal Title
  
  Mol Hum Reprod. 13
  
  Pages: 141-148
- NAID
  120000801922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Journal Article] Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/□ cnull immunodeficient mice2007
- Author(s)
  Masuda H, Maruyama T^*, Hiratsu E, Yamane J, Iwanami A, Nagashima T, Ono M, Miyoshi H, Okano HJ, Ito M, Tamaoki N, Nomura T, Okano H, Matsuzaki Y, Yoshimura Y
- Journal Title
  
  Proc Natl Acad Sci USA 104
  
  Pages: 1925-1930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659426
[Presentation] Bone morphogenic protein 4 (BMP4) is required for establishment of an adequate uterine decidualization and vascularization to support normal pregnancy2018
- Author(s)
  Nagashima T, Ishida M, Tanaka K, Matsushima M, Matsuzawa Y, Izawa T, Furukawa S, Kobayashi Y, Iwashita M
- Organizer
  第70回日本産科婦人科学会・学術講演会
- Data Source
  KAKENHI-PROJECT-16K11105
[Presentation] The role of uterine smooth muscle stem cells, isolated based on cell surface markers, in myometrial remodeling in the pregnant uterus.2009
- Author(s)
  Ono M, Maruyama T, Kajitani T, Uchida H, Oda H, Nishikawa S, Kagami M, Arase T, Nagashima T, Masuda H, Morikawa S, Mabuchi Y, Okano Y, Matsuzaki Y, Yoshimura Y
- Organizer
  56th Society for Gynecologic Investigation
- Place of Presentation
  Glasgow, Scotland
- Data Source
  KAKENHI-PROJECT-19659426
[Presentation] 子宮平滑筋幹細胞の新しい分離法とその機能解析.2008
- Author(s)
  小野政徳, 丸山哲夫, 梶谷宇, 内田浩, 荒瀬透, 小田英之, 西川明花, 長島隆, 升田博隆, 馬渕洋, 森川暁, 岡野栄之, 松崎有未, 吉村泰典
- Organizer
  第81回日本内分泌学会学術総会
- Place of Presentation
  青森県弘前市
- Data Source
  KAKENHI-PROJECT-19659426
[Presentation] Chemial abortionの既往を有する反復流産患者の病院および妊娠転帰に関する検討.2008
- Author(s)
  西川明花, 丸山哲夫, 小田英之, 各務真紀, 荒瀬透, 小野政徳, 長島隆, 内田浩, 吉村泰典
- Organizer
  第53回日本生殖医学会
- Place of Presentation
  神戸市中央区
- Data Source
  KAKENHI-PROJECT-19659426
[Presentation] ヒト子宮内膜幹様細胞の同定. 分離とその幹細胞特性の機能解析.2008
- Author(s)
  升田博隆, 丸山哲夫, 小野政徳, 長島隆, 梶谷宇, 内田浩, 浅田弘法, 岡野栄之, 松崎有未, 吉村泰典
- Organizer
  第13回日本生殖内分泌学会
- Place of Presentation
  大阪市北区
- Year and Date
  2008-11-29
- Data Source
  KAKENHI-PROJECT-19659426
[Presentation] 常位胎盤早期剥離・子宮内胎児発育遅延モデルマウスの開発 ― BMPR2は胎盤形成期における母体胎児間の血管形成に必須である ― ．
- Author(s)
  長島　隆，Martin M. Matzuk，丸山哲夫，吉村泰典，青木大輔
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  国際フォーラム（東京都千代田区）
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-26670728

1. Maruyama Tetsuo (10209702)

# of Collaborated Projects: 3 results

# of Collaborated Products: 18 results
2. Ota Kuniaki (90424142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 梶谷宇 (60407111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results

NAGASHIMA TAKASHI 長島 隆

長島 隆 ナガシマ タカシ

Research Projects

Research Products

Co-Researchers

Trial for Innovative Therapy against Placental Abruption by Using Model MousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The immune regulatory activated by Vitamin D has been the novel treatment for recurrent implantation failure and recurrent pregnancy losses

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of pathologic conditions and development of innovative medical care for placental abruption by using NMR methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

分泌蛋白プロファイリング(secretome)によるマウス初期胚の機能評価

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CD34 and CD49f double-positive and lineage marker-negative cells isolated from human myometrium exhibit stem cell-like properties involved in pregnancy-induced uterine remodeling.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The UDP-glucose receptor P2RY14 triggers innate mucosalimmunity in the female reproductive tract by inducing IL-8.2009

Author(s)

Journal Title

Data Source

[Journal Article] Analysis of serum FSH bioactivity in a patient with an FSH-secreting pituitary microadenoma and multicystic ovaries : A case report.2008

Author(s)

Journal Title

Data Source

[Journal Article] 【子宮内膜の機能と生殖医療 その最前線】子宮内膜脱落膜化の機序の解明 チロシンキナーゼSRCの役割と意義2008

Author(s)

Journal Title

Data Source

[Journal Article] Activation of SRC kinase and phosphorylation of signal transducer and activator of transcription-5 are required for decidual transformation of human endometrial stromal cells.2008

Author(s)

Journal Title

Data Source

[Journal Article] Pregnancy outcomes of reciprocal translocation carriers who have a history of repeated pregnancy loss.2008

Author(s)

Journal Title

Data Source

[Journal Article] 妊娠子宮における子宮筋Side Population細胞の役割.2008

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Glycodelin blocks progression to S phase and inhibits cell growth : a possible progesterone-induced regulator for endometrial epithelial cell growth.2008

Author(s)

Journal Title

Data Source

[Journal Article] 着床期特異的蛋白glycodelinによる子宮内膜腺上皮細胞の増殖機能制御.2008

Author(s)

Journal Title

Data Source

[Journal Article] Side population in human uterine myometrium displays phenotypic and functional chafacteristics of myometrial stem cells2007

Author(s)

Journal Title

Data Source

[Journal Article] Histone deacetylase inhibitors stimulate cell migration in human endometdalMol Hum Reprod.adenocarcinoma cells through up-regulation of glycodelin2007

Author(s)

Journal Title

Data Source

[Journal Article] Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis2007

Author(s)

Journal Title

NAID

Data Source

NAGASHIMA TAKASHI 長島隆

長島隆ナガシマタカシ

[Journal Article] 【子宮内膜の機能と生殖医療その最前線】子宮内膜脱落膜化の機序の解明チロシンキナーゼSRCの役割と意義2008