Kinoshita Ichiro 木下一郎

… Alternative Names

Researcher Number	40343008
Other IDs
External Links
Affiliation (Current)	2020: 北海道大学, 大学病院, 教授
Affiliation (based on the past Project Information) *help	2020: 北海道大学, 大学病院, 教授 2017 – 2018: 北海道大学, 医学研究院, 准教授 2016: 北海道大学, 医学研究科, 准教授 2012 – 2015: 北海道大学, 医学(系)研究科(研究院), 准教授 2014: 北海道大学, 大学院医学研究科, 准教授 … More
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Respiratory organ internal medicine / Tumor diagnosis / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 肺癌 / EZH2 / AP-1 / c-jun / 転写因子 / cJun / 癌幹細胞 / 幹細胞 / HDAC / エピジェネティクス … More Except Principal Investigator 肺癌 / 非小細胞肺癌 / 糖転移酵素 / α1,6-フコース転移酵素 / AKR1B10 / バイオマーカー / 糖鎖 / 糖転移酵素〓1-6fucosyltransferase / alfa 1-6フコース転移酵素 / alfa1,6-フコース転移酵素 / 併用治療効果 / Notch / Ｎｏｔｃｈ / Ｂｉｍ / Bcl2 family / Lung cancer / 国際情報交換 / EGFR-TKI / 薬剤耐性 / FRETバイオセンサー / バイオイメージング / フェルスター共鳴エネルギー移動 / 分子マーカー / EGF受容体遺伝子変異 / 喫煙 / 扁平上皮癌 / タバコ発癌 / lung cancer / biomarker / EGFR mutation / Numbの機能 Less

Optimization of treatment strategy with EZH2 inhibitor for solid cancer with SWI/SNF alterationPrincipal InvestigatorOngoing
- Principal Investigator
  
  木下一郎
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Hokkaido University
肺癌組織系の違いによるNumbの肺癌増殖に対する機能についてOngoing
- Principal Investigator
  
  榊原純 (小西純)
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Hokkaido University
非小細胞肺癌における抗癌薬耐性化の克服を目指したヒストン修飾酵素阻害療法の開発Principal InvestigatorOngoing
- Principal Investigator
  
  木下一郎
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Combined inhibition of stem cell markers and histone modification enzymes in non-small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Kinoshita Ichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Study on EGFR-TKI resistance using FRET biosensor
- Principal Investigator
  
  Akita Hirotoshi
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Combined antitumor effec ot g-secretase inbitiro and ABT-737
- Principal Investigator
  
  SAKAKIBARA Jun
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Targeted therapy for cancer stem-like cells of non-small cell lung cancers with inhibition of the cJun transcription factorPrincipal Investigator
- Principal Investigator
  
  KINOSHITA Ichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Alteration of fucosylation and biomarker development in lung cancer
- Principal Investigator
  
  AKITA Hirotoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnosis
- Research Institution
  Hokkaido University
Identification of novel molecular targets for lung cancer based on different sensitivity to AP-1 blockadePrincipal Investigator
- Principal Investigator
  
  KINOSHITA Ichiro
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
肺癌および随伴肺疾患における糖転移酵素の発現異常に関する研究
- Principal Investigator
  
  AKITA Hirotoshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Research on Molecular Therapeutic Targets and Biomarkers for the Diagnosis and Stratification in Lung Cancer
- Principal Investigator
  
  AKITA Hirotoshi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Hokkaido University
Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant negative mutant, TAM67Principal Investigator
- Principal Investigator
  
  KINOSHITA Ichiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  HOKKAIDO UNIVERSITY

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2004 Other

All Journal Article Presentation

[Journal Article] DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail2019
- Author(s)
  Furuta Megumi、Kikuchi Hajime、Shoji Tetsuaki、Takashima Yuta、Kikuchi Eiki、Kikuchi Junko、Kinoshita Ichiro、Dosaka‐Akita Hirotoshi、Sakakibara‐Konishi Jun
- Journal Title
  
  Cancer Science
  
  Volume: in print
- DOI
  10.1111/cas.13997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639
[Journal Article] Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma.2018
- Author(s)
  Kikuchi Hajime、Sakakibara-Konishi Jun、Furuta Megumi、Kikuchi Eiki、Kikuchi Junko、Oizumi Satoshi、Hida Yasuhiro、Kaga Kichizo、Kinoshita Ichiro、Dosaka-Akita Hirotoshi、Nishimura Masaharu
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 29379-29391
- DOI
  10.18632/oncotarget.25585
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-18K08130
[Journal Article] Clinicopathologic Features and Immune Microenvironment of Non?Small-cell Lung Cancer With Primary Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors2018
- Author(s)
  Takashima Yuta、Sakakibara-Konishi Jun、Hatanaka Yutaka、Hatanaka Kanako C.、Ohhara Yoshihito、Oizumi Satoshi、Hida Yasuhiro、Kaga Kichizo、Kinoshita Ichiro、Dosaka-Akita Hirotoshi、Matsuno Yoshihiro、Nishimura Masaharu
- Journal Title
  
  Clinical Lung Cancer
  
  Volume: 19 Pages: 352-359
- DOI
  10.1016/j.cllc.2018.02.004
- NAID
  120006649179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639
[Journal Article] A phase II study of carboplatin, pemetrexed, and bevacizumab followed by erlotinib and bevacizumab maintenance for non-squamous non-small cell lung cancer with wild-type EGFR (HOT1101)2018
- Author(s)
  Takashina T, Asahina H, Oizumi S, Yamada N, Harada M, Takamura K, Yokouchi H, Harada T, Honjo O, Ogi T, Morikawa N, Kinoshita I, Honda R, Nakano K, Kanazawa K, Amano T, Dosaka-Akita H, Isobe H, Nishimura M
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 23 Pages: 1060-1069
- DOI
  10.1007/s10147-018-1318-z
- NAID
  120006651802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09639
[Journal Article] Updated survival outcomes of NEJ005/TCOG0902: a randomised phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations2018
- Author(s)
  Oizumi S, Sugawara S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Watanabe S, Ito K, Gemma A, Demura Y, Fukumoto S, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Aiba K, Nukiwa T.
- Journal Title
  
  ESMO Open
  
  Volume: 3(2)
- DOI
  10.1136/esmoopen-2017-000313
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09562, KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K09168, KAKENHI-PROJECT-15K09237
[Journal Article] Combined antitumor effect of γ-secretase inhibitor and ABT-737 in Notch-expressing non-small cell lung cancer2017
- Author(s)
  Sakakibara-Konishi J, Ikezawa Y, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 22 Pages: 481-487
- DOI
  10.1007/s10147-016-1060-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461175
[Journal Article] A randomized phase II trial of erlotinib vs. S-1 as a third- or fourth-line therapy for patients with wild-type EGFR non-small cell lung cancer (HOT1002)2017
- Author(s)
  Ikezawa Y, Asahina H, Oizumi S, Watanabe M, Takamura K, Kawai Y, Yamada N, Harada T, Kinoshita I, Fujita Y, Miyauchi E, Ogi T, Amano T, Furuta M, Sakakibara-Konishi J, Nishihara H, Dosaka-Akita H, Isobe H, Nishimura M; Hokkaido Lung Cancer Clinical Study Group
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 80 Pages: 955-963
- DOI
  10.1007/s00280-017-3432-4
- NAID
  120006533131
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09639, KAKENHI-PROJECT-15K09164
[Journal Article] Novel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer2016
- Author(s)
  Elmansuri AZ, Tanino MA, Mahabir R, Wang L, Kimura T, Nishihara H, Kinoshita I, Dosaka-Akita H, Tsuda M and Tanaka S
- Journal Title
  
  Oncotarget
  
  Volume: （in press） Pages: 27094-107
- DOI
  10.18632/oncotarget.8314
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K15106, KAKENHI-PROJECT-25460471, KAKENHI-PROJECT-26670414, KAKENHI-PROJECT-15K08359, KAKENHI-PROJECT-16K08703
[Journal Article] A phase II study of bevacizumab with carboplatin-pemetrexed in non-squamous non-small cell lung carcinoma patients with malignant pleural effusions: North East Japan Study Group Trial NEJ013A2016
- Author(s)
  Usui K, Sugawara S, Nishitsuji M, Fujita Y, Inoue A, Mouri A, Watanabe H, Sakai H, Kinoshita I, Ohhara Y, Maemondo M, Kagamu H, Hagiwara K, Kobayashi K
- Journal Title
  
  Lung Cancer
  
  Volume: 99 Pages: 131-136
- DOI
  10.1016/j.lungcan.2016.07.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293196, KAKENHI-PROJECT-26461175
[Journal Article] Combined inhibition of EZH2 and HDACs as a potential epigenetic therapy for non-small cell lung cancer cells2016
- Author(s)
  Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M, and Dosaka-Akita H
- Journal Title
  
  Cancer Sci
  
  Volume: （in press）
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461175
[Journal Article] Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers2015
- Author(s)
  Honma R, Kinoshita I, Miyoshi E, Tomaru U, Matsuno Y, Shimizu Y, Takeuchi S, Kobayashi Y, Kaga K, Taniguchi N, Dosaka-Akita H
- Journal Title
  
  Oncology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461175
[Journal Article] Factors associated with a poor response to gefitinib in the NEJ002 study: Smoking and the L858R mutation2015
- Author(s)
  Fukuhara T, Yoshizawa H et al.
- Journal Title
  
  Lung Cancer
  
  Volume: 88 Pages: 181-186
- DOI
  10.1016/j.lungcan.2015.02.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K15320
[Journal Article] The coordinated actions of TIM-3 on cancer and myeloid cells in the regulation of tumorigenicity and clinical prognosis in clear cell renal cell carcinomas2015
- Author(s)
  Komohara Y, Morita T, Annan DA, Horlad H, Ohnishi K, Yamada S, Nakayama T, Kitada S, Suzu S, Kinoshita I, Dosaka-Akita H, Akashi K, Takeya M, Jinushi M
- Journal Title
  
  Cancer Immunol Res
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461175
[Journal Article] Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations: NEJ005/TCOG09022015
- Author(s)
  Sugawara S, Oizumi S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Yoshizawa H, Ito K, Gemma A, Nishitsuji M, Harada M, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Kurihara M, Nukiwa T; North East Japan Study Group and Tokyo Cooperative Oncology Group
- Journal Title
  
  Ann Oncol
  
  Volume: 26(5) Pages: 888-94
- DOI
  10.1093/annonc/mdv063
- NAID
  120005702354
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K09164
[Journal Article] Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses.2014
- Author(s)
  Yamashina T, Baghdadi M, Yoneda A, Kinoshita I, Suzu S, Dosaka-Akita H, Jinushi M.
- Journal Title
  
  Cancer Metastasis Rev.
  
  Volume: 74 Pages: 2698-2709
- DOI
  10.1158/0008-5472.can-13-2169
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23591132, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-26290050, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-26670183
[Journal Article] CD133 expression : a potential prognostic marker for non-small cell lung cancers2014
- Author(s)
  Mizugaki H, Sakakibara-Konishi J, Kinoshita I, Dosaka-Akita H, (他7名)
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 19 Pages: 254-259
- DOI
  10.1007/s10147-013-0541-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591132
[Journal Article] Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin–paclitaxel for chemo-Naïve non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002).2013
- Author(s)
  Inoue A, Kobayashi K, Maemondo M, et al
- Journal Title
  
  Ann Oncol.
  
  Volume: 24 Pages: 54-59
- DOI
  10.1093/annonc/mds214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790746, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-24659396
[Journal Article] TIM-4 glycoprotein - mediated degradation of dying tumor cells by autophagy leads to reduced antigen presentation and increased immune tolerance2013
- Author(s)
  Baghdadi M, Yoneda A, Yamashina T, Nagao H, Komohara Y, Nagai S, Akiba H, Foretz M, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Takeya M, Viollet B, Yagita H, Jinushi M
- Journal Title
  
  Immunity
  
  Volume: 39 Pages: 1070-1081
- DOI
  10.1016/j.immuni.2013.09.014
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-24790479, KAKENHI-PUBLICLY-25112701, KAKENHI-PUBLICLY-25130701, KAKENHI-PROJECT-25293089, KAKENHI-PROJECT-25461503
[Journal Article] Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between thereceptor TIM-3 and the alarmin HMGB12012
- Author(s)
  Chiba, M. Baghdadi, H. Akiba, H. Yoshiyama, I. Kinoshita, H. Dosaka-Akita, Y. Fujioka, Y. Ohba, J. V. Gorman, J. D. Colgan, M. Hirashima, T. Uede, A. Takaoka, H. Yagita and M. Jinushi.
- Journal Title
  
  Nature Immunology
  
  Volume: 13 Pages: 832-42
- DOI
  10.1038/ni.2376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04616, KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-22240089, KAKENHI-PROJECT-22590360, KAKENHI-PROJECT-22591098, KAKENHI-PROJECT-23390090, KAKENHI-PROJECT-23501283, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132, KAKENHI-PROJECT-23659196, KAKENHI-PUBLICLY-23114501
[Journal Article] Expression of Bim, Noxa, and Puma in non-small cell lung cancer.2012
- Author(s)
  Sakakibara-Konishi J, Oizumi S, Kikuchi J, Kikuchi E, Mizugaki H, Kinoshita I, Dosaka-Akita H, Nishimura M
- Journal Title
  
  BMC Cancer.
  
  Volume: 12 Pages: 286-286
- DOI
  10.1186/1471-2407-12-286
- NAID
  120004756336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591146
[Journal Article] Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2,inhibits growth of non-small cell lung cancer cells2012
- Author(s)
  Kikuchi J, Takashina T, Kinoshita I, Kikuchi E, Shimizu Y , (他5名)
- Journal Title
  
  Lung Cancer
  
  Volume: 78 Pages: 138-143
- DOI
  10.1016/j.lungcan.2012.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591132
[Journal Article] ATM-Mediated DNA Damage Signals Mediate Immune Escape through Integrin-alphavbeta3-Dependent Mechanisms2012
- Author(s)
  Jinushi M
- Journal Title
  
  Cancer Research
  
  Volume: 72 Pages: 56-65
- DOI
  10.1158/0008-5472.can-11-2028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390113, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
[Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.2011
- Author(s)
  Kikuchi J, Kinoshita I, Birrer MJ, Dosaka-Akita H
- Journal Title
  
  Lung Cancer. 72
  
  Pages: 229-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] Tumor-associated macrophages regulate tumorigenicity and anti-cancer drug responses of cancer stem/initiating cells.2011
- Author(s)
  Jinushi M, Chiba S, Yoshiyama H, Masutomi K, Kinoshita I, Dosaka-Akita H, Yagita H, Takaoka A, Tahara H
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 108 Pages: 112425-12430
- DOI
  10.1073/pnas.1106645108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-21689031, KAKENHI-PROJECT-22240089, KAKENHI-PUBLICLY-23130501, KAKENHI-PROJECT-23590534, KAKENHI-PROJECT-23591132
[Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer2011
- Author(s)
  Kikuchi J, Kinoshita I, Shimizu Y, Kikuchi E, Takeda K, Aburatani H, Oizumi S, Konishi J, Kaga K, Matsuno Y, Birrer MJ, Nishimura M and Dosaka-Akita H
- Journal Title
  
  Lung Cancer
  
  Volume: 72 Pages: 229-237
- DOI
  10.1016/j.lungcan.2010.08.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591132
[Journal Article] Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis2011
- Author(s)
  Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T and Dosaka-Akita H
- Journal Title
  
  Anticancer Res
  
  Volume: 31 Pages: 263-270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591132
[Journal Article] Distinctive expression of the polycomb group proteins Bmil polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.2010
- Author(s)
  Kikuchi J, Kinoshita I, et.al.
- Journal Title
  
  Cancer
  
  Volume: 116 Pages: 3015-3024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] Minichromosome maintenance (MCM) protein 4 as a marker for proliferation and its clinical and clinicopathological significance in non-small cell lung cancer.2010
- Author(s)
  Kikuchi J, Kinoshita I, et.al.
- Journal Title
  
  Lung Cancer
  
  Volume: 172(9月(Epub))
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] Distinctive expression of the polycomb group proteins Bmi1 polycomb ring finger oncogene and enhancer of zeste homolog 2 in nonsmall cell lung cancers and their clinical and clinicopathologic significance.2010
- Author(s)
  Kikuchi J, Kinoshita I, Dosaka-Akita H
- Journal Title
  
  Cancer 116
  
  Pages: 3015-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells.2008
- Author(s)
  Kikuchi J, Kinoshita I, Birrer MJ, Dosaka-Akita H
- Journal Title
  
  Br J Cancer 99(12)
  
  Pages: 2013-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590909
[Journal Article] 肺癌の遺伝子異常2004
- Author(s)
  木下一郎, 他
- Journal Title
  
  呼吸と循環 52・10
  
  Pages: 1059-1064
- Data Source
  KAKENHI-PROJECT-16590729
[Presentation] JARID1 family inhibitor reduces generation of drug resistant EGFR-mutation positive lung cancer cells2019
- Author(s)
  Ariga S, Kinoshita I, Kikuchi J, Shimizu S, Dosaka-Akita H
- Organizer
  110th Annual Meeting of the American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] JARID1ファミリー阻害薬はEGFR変異陽性肺癌細胞株の薬剤耐性化を緩和する2018
- Author(s)
  有賀伸, 木下一郎, 菊地順子, 清水康, 秋田弘俊
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] DLL3 regulates migration and invasion of Small Cell Lung Cancer2018
- Author(s)
  Megumi Furuta1, Jun Sakakibara-Konishi1, Tetsuaki Shoji1, Yuta Takashima1, Hajime Kikuchi 1, Eiki Kikuchi1, Junko Kikuchi1, Ichiro Kinoshita2, Hirotoshi Dosaka-Akita2, Masaharu Nishimura1
- Organizer
  AACR
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08130
[Presentation] A phase II study of trastuzumab monotherapy in pretreated patients with non-small cell lung cancers (NSCLCs) harboring HER2 alterations: HOT1303-B trial2018
- Author(s)
  Kinoshita I, Goda T, Watanabe K, Maemondo M, Oizumi S, Amano T, Hatanaka Y, Matsuno Y, Nishihara H, Asahina H, Harada T, Goto K, Isobe H, Nishimura M, Dosaka-Akita H
- Organizer
  European Society for Medical Oncology 2018 Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] JARIDファミリー阻害薬の非小細胞肺癌細胞株に対する効果2017
- Author(s)
  有賀伸、木下一郎、菊地順子、清水康、秋田弘俊
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09639
[Presentation] 非小細胞肺癌におけるヒストン修飾酵素阻害療法に関する研究2017
- Author(s)
  木下一郎、秋田弘俊
- Organizer
  第二回北大・部局横断シンポジウム
- Place of Presentation
  北海道大学（北海道・札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-26461175
[Presentation] EZH2阻害薬とヒストン脱アセチル化酵素（HDAC）阻害薬の併用療法の非小細胞肺癌（NSCLC）細胞に対する抗腫瘍効果2014
- Author(s)
  木下一郎，高階太一、菊地順子、榊原純、大泉聡史、西村正治、秋田弘俊
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  TKPガーデンシティ仙台（宮城県・仙台市）
- Year and Date
  2014-06-26
- Data Source
  KAKENHI-PROJECT-26461175
[Presentation] Prognostic significance of 〓1,6 fucosyltransferase (〓1,6 FT) in non-small cell lung cancers (NSCLCs).2013
- Author(s)
  Honma R, Dosaka-Akita H, Kinoshita I
- Organizer
  2013 Annual Meeting of American Society of Clinical Oncology (ASCO).
- Place of Presentation
  McCormick Place (シカゴ、米国).
- Year and Date
  2013-06-01
- Data Source
  KAKENHI-PROJECT-22501029
[Presentation] Pharmacologic disruption of polycomb group protein EZH2 via 3-Deazaneplanocin A inhibits growth of non-small cell lung cancer cells2012
- Author(s)
  Kinoshita I
- Organizer
  5th Asia Pacific Lung Cancer Conference
- Place of Presentation
  Hilton Fukuoka Sea Hawk, Fukuoka
- Year and Date
  2012-11-26
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Role of polycomb group protein EZH2 in lung cancer2012
- Author(s)
  Kinoshita I
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  教育文化会館, 札幌市
- Year and Date
  2012-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin2011
- Author(s)
  木下一郎，菊地順子，菊地英毅, 清水康, 榊原純, 大泉聡史, 西村正治, 秋田弘俊
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知）
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] GDP-mannose-4,6-dehydratase (GMD) and GDP-fucose transporter in non-small cell lung cancers (NSCLCs) : their decreased expression insquamous cell carcinomas by immunohistochemistry.2011
- Author(s)
  Honma R, Dosaka-Akita H, Kinoshita I
- Organizer
  14th World Conference on Lung Cancer of International Association for the Studyof Lung Cancer.
- Place of Presentation
  Amsterdam RAI(アムステルダム、オランダ)
- Year and Date
  2011-07-05
- Data Source
  KAKENHI-PROJECT-22501029
[Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011
- Author(s)
  Kinoshita I, Kikuchi J, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M, Dosaka-Akita H
- Organizer
  9th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  北海道大学（札幌市）
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Decreased expression of GMDand GDP-fucose transporter is associated with squamous histology in NSCLCs.2011
- Author(s)
  Honma R, Dosaka-Akita H, Kinoshita I
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場.
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22501029
[Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011
- Author(s)
  Kinoshita I
- Organizer
  9th International Symposium for Future Drug Discovery and Medical Care
- Place of Presentation
  Hokkaido University, Sapporo
- Year and Date
  2011-09-30
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Growth inhibition of non-small cell lung cancer cells by the histone methyltransferase ezh2 inhibitor 3-deazaneplanocin2011
- Author(s)
  Kinoshita I
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場, 名古屋市
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Decreased expression of GMD in non-small cell lung cancers (NSCLCs).2011
- Author(s)
  Honma R, Dosaka-Akita H, Kinoshita I
- Organizer
  102nd Annual Meeting of AmericanAssociation of Cancer Research (AACR).
- Place of Presentation
  Orange CountyConvention Center(オーランド、米国)
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-22501029
[Presentation] Distinctive expression of polycomb group proteins Bmil and EZH2 in nonsmall cell lung cancers and their clinical and clinicopathological significance.2010
- Author(s)
  Kikuchi J, Kinoshita I, et.al.
- Organizer
  101th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Washington Convention Center (Washington, DC, USA)
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-20590909
[Presentation] 非小細胞肺癌におけるポリコーム蛋白質Bmi1とEZH2の発現の違いと臨床病理学的意義2010
- Author(s)
  木下一郎, 他
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪府)
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-20590909
[Presentation] The role of minichromosome maintenance (MCM) protein 4 in proliferation and its clinicopathological significance in non-small cell lung cancers (NSCLCs).2009
- Author(s)
  Kinoshita I.
- Organizer
  13th World Conference of Lung Cancer
- Place of Presentation
  San Francisco, USA
- Year and Date
  2009-08-02
- Data Source
  KAKENHI-PROJECT-20590909
[Presentation] The role of minichromosome maintenance(MCM)protein 4 in proliferation and its clinicopathological significance in non-small cell lung cancers(NSCLCs).2009
- Author(s)
  Kinoshita I, et.al.
- Organizer
  13th World Conference of Lung Cancer
- Place of Presentation
  San Francisco, USA
- Year and Date
  2009-08-03
- Data Source
  KAKENHI-PROJECT-20590909
[Presentation] Effects of combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin and the histone deacetylase inhibitor SAHA on non-small cell lung cancer cells
- Author(s)
  Takashina T, Kinoshita I, Kikuchi J, Shimizu Y, Konishi JS, Oizumi S, Nishimura M and Dosaka-Akita H
- Organizer
  the 105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego Conventon Center (San Diego)
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] EZH2阻害薬とヒストン脱アセチル化酵素阻害薬の併用療法の非小細胞肺癌細胞に対する抗腫瘍効果の検討
- Author(s)
  高階太一、木下一郎、菊地順子、池澤靖元、榊原純、大泉聡史、西村正治、秋田弘俊
- Organizer
  第54回日本肺癌学会総会
- Place of Presentation
  ホテルニューオータニ（東京）
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Pharmacologic disruption of polycomb group protein EZH2 via 3-Deazaneplanocin A inhibits growth of non-small cell lung cancer cells
- Author(s)
  Kinoshita I
- Organizer
  5th Asia Pacific Lung Cancer Conference
- Place of Presentation
  Hilton Fukuoka Sea Hawk (Fukuoka)
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] ヒストンメチル化酵素EZH2阻害剤3-deazaneplanocin Aによる非小細胞肺癌細胞株に対する増殖抑制効果の検討
- Author(s)
  高階太一、木下一郎、菊地順子、菊地英毅、清水康、榊原純、大泉聡史、西村正治、秋田弘俊
- Organizer
  第53回日本肺癌学会総会
- Place of Presentation
  岡山コンベンションセンター（岡山市）
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Role of polycomb group protein EZH2 in lung cancer
- Author(s)
  Kinoshita I
- Organizer
  第71会日本癌学会学術総会
- Place of Presentation
  教育文化会館（札幌市）
- Invited
- Data Source
  KAKENHI-PROJECT-23591132
[Presentation] Effects of combined epigenetic therapy with EZH2 and HDAC inhibitors on NSCLC cells
- Author(s)
  Takashina T, Kinoshita I, Kikuchi J, Kikuchi E, Shimizu Y, Sakakibara-Konishi J, Oizumi S, Nishimura M and Dosaka-Akita H
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23591132

1. AKITA Hirotoshi (70222528)

# of Collaborated Projects: 7 results

# of Collaborated Products: 16 results
2. SAKAKIBARA Jun (50374278)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. SHIMIZU Yasushi (10374513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. JINUSHI Masahisa (40318085)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. Ohba Yusuke (30333503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. YAMAZAKI Koichi (20312358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 三善英知 (20322183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TANINO Mishie

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. YOSHIZAWA Hirohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. GENMA Akihiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. OIZUMI Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
12. KOMOHARA Yoshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. INOUE Kenich

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. WATANABE Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 津田真寿美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 田中伸哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 木村太一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 谷野功典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 前門戸任

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. 西條康夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 井上彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 各務博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 八木田秀雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
24. 秋葉久弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 吉山裕規

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
26. 永井重徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 竹屋元裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 田原秀晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 小林国彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kinoshita Ichiro 木下 一郎

木下 一郎 キノシタ イチロウ

KINOSHITA Ichiro 木下 一郎

Research Projects

Research Products

Co-Researchers

Optimization of treatment strategy with EZH2 inhibitor for solid cancer with SWI/SNF alterationPrincipal InvestigatorOngoing

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肺癌組織系の違いによるNumbの肺癌増殖に対する機能についてOngoing

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非小細胞肺癌における抗癌薬耐性化の克服を目指したヒストン修飾酵素阻害療法の開発Principal InvestigatorOngoing

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Combined inhibition of stem cell markers and histone modification enzymes in non-small cell lung cancerPrincipal Investigator

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Study on EGFR-TKI resistance using FRET biosensor

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Combined antitumor effec ot g-secretase inbitiro and ABT-737

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Targeted therapy for cancer stem-like cells of non-small cell lung cancers with inhibition of the cJun transcription factorPrincipal Investigator

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Alteration of fucosylation and biomarker development in lung cancer

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Identification of novel molecular targets for lung cancer based on different sensitivity to AP-1 blockadePrincipal Investigator

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肺癌および随伴肺疾患における糖転移酵素の発現異常に関する研究

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Research on Molecular Therapeutic Targets and Biomarkers for the Diagnosis and Stratification in Lung Cancer

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Growth inhibition of non-small cell lung cancer cells by AP-1 blockade using a cJun dominant negative mutant, TAM67Principal Investigator

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[Journal Article] DLL3 regulates the migration and invasion of small cell lung cancer by modulating Snail2019

Author(s)

Kinoshita Ichiro 木下一郎

木下一郎キノシタイチロウ

KINOSHITA Ichiro 木下一郎