IWATA Masaaki 岩田正明

Researcher Number	40346367
Other IDs
Affiliation (Current)	2025: 鳥取大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 鳥取大学, 医学部, 教授 2016 – 2021: 鳥取大学, 医学部, 准教授 2014 – 2015: 鳥取大学, 医学部附属病院, 講師 2013: 鳥取大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator Basic Section 10030:Clinical psychology-related / Basic Section 58070:Lifelong developmental nursing-related / Basic Section 52010:General internal medicine-related / Medium-sized Section 52:General internal medicine and related fields / Hygiene and public health
Keywords	Principal Investigator NLRP3 / 炎症 / ストレス / うつ病 / βヒドロキシ酪酸 / インフラマソーム / IL-1β / BHB / 精神疾患 / 炎症性サイトカイン … More / NLRP３ / TNFα / サイトカイン / 国際情報交換 / グルタミン酸 / ATP / マイクログリア / アストロサイト / IL-1beta … More Except Principal Investigator うつ病 / 認知機能障害 / 認知症 / アルツハイマー病 / グルタミン酸 / xc-系 / xCT / ミクログリア / 思考の柔軟性 / 神経心理検査 / 思考の柔軟性検査 / スマートフォン / 産褥期 / 認知機能低下 / うつ / パーキンソン病 / うつ症状 / 抗体 / アルツハイマー病 / 抗体療法 / 分子標的療法 / ファージディスプレイ / ウェアラブル端末 / タブレット端末 / サブタイプ分類 / スクリーニング Less

Clinical development of a novel, patient-optimized, inflammation-targeted antidepressantPrincipal Investigator
- Principal Investigator
  
  岩田正明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tottori University
Effects of smartphone use during the postpartum period on sleep and fatigue
- Principal Investigator
  
  廣田颯香
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58070:Lifelong developmental nursing-related
- Research Institution
  Tottori College of Nursing
Development of Cognitive Flexibility Test to Easily Assess Cognitive Impairment in Depression
- Principal Investigator
  
  福崎俊貴
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 10030:Clinical psychology-related
- Research Institution
  Tottori University
βヒドロキシ酪酸の抗うつメカニズムの解明と炎症標的新規抗うつ薬としての臨床開発Principal Investigator
- Principal Investigator
  
  岩田正明
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tottori University
Development of innovative dementia antibody therapy targeting microglial membrane proteins with few side effects
- Principal Investigator
  
  NAKASO Kazuhiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Tottori University
Identifing of common mechanisms of depression and cognitive decline associated with systemic diseases and application to treatment
- Principal Investigator
  
  NAKASO Kazuhiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Tottori University
Development of screening tool for subtype classification of depression
- Principal Investigator
  
  NAKAYAMA Shigeki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  Yonago National College of Technology
Development of novel therapeutic strategy for mental disorders targeting NLRP3 inflammasomePrincipal Investigator
- Principal Investigator
  
  IWATA Masaaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Tottori University
Investigating the mechanisms of stress-induced depression via neuroinflammation and development of the new strategy for the treatment of depression.Principal Investigator
- Principal Investigator
  
  Iwata Masaaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Tottori University
Psychological stress activates the inflammasome via release of ATP and stimulation of the P2X7 receptorPrincipal Investigator
- Principal Investigator
  
  IWATA Masaaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Tottori University

All 2023 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] Depression Frontier 22016
- Author(s)
  岩田正明
- Total Pages
  138
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15K19729
[Book] Depression Frontier 22016
- Author(s)
  朝田隆、野村聡一郎、井上猛、戸田裕之、朴秀賢、金沢徹文、菱本明豊、沼田周助、淵上学、岩田正明
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15K19729
[Journal Article] Commitment profiles among nurses: combinations of organizational commitment forms and work engagement, psychological distress, and turnover intention2023
- Author(s)
  FUKUZAKI Toshiki、TAKEDA Shinya、IWATA Noboru、OOBA Sawako、INOUE Masahiko
- Journal Title
  
  Industrial Health
  
  Volume: 61 Issue: 3 Pages: 232-236
- DOI
  10.2486/indhealth.2021-0237
- ISSN
  0019-8366, 1880-8026
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K02937
[Journal Article] Gender Differences in the Motivational Process of the Job Demands-Resources Model2023
- Author(s)
  Fukuzaki Toshiki、Iwata Noboru
- Journal Title
  
  Yonago Acta Medica
  
  Volume: 66 Issue: 3 Pages: 326-333
- DOI
  10.33160/yam.2023.08.001
- ISSN
  0513-5710, 1346-8049
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K02937
[Journal Article] The impact of negative and positive affectivity on the relationship between work-related psychological factors and work engagement in Japanese workers: a comparison of psychological distress2023
- Author(s)
  Fukuzaki Toshiki、Iwata Noboru
- Journal Title
  
  BMC Psychology
  
  Volume: 11 Issue: 1 Pages: 219-219
- DOI
  10.1186/s40359-023-01250-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K02937
[Journal Article] 精神疾患に対する抗炎症療法の可能性2019
- Author(s)
  岩田正明
- Journal Title
  
  日本医事新報
  
  Volume: 4942 Pages: 40-47
- Data Source
  KAKENHI-PROJECT-17K10273
[Journal Article] うつ病の炎症性神経障害仮説2018
- Author(s)
  岩田正明
- Journal Title
  
  日本生物学的精神医学会誌
  
  Volume: 29 Pages: 163-167
- NAID
  130007740932
- Data Source
  KAKENHI-PROJECT-17K10273
[Journal Article] βヒドロキシ酪酸の抗うつ作用の発見2018
- Author(s)
  岩田正明
- Journal Title
  
  BIO INDUSTRY
  
  Volume: 35 Pages: 54-61
- Data Source
  KAKENHI-PROJECT-17K10273
[Journal Article] Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses2017
- Author(s)
  Yamanashi Takehiko、Iwata Masaaki、Kamiya Naho、Tsunetomi Kyohei、Kajitani Naofumi、Wada Nodoka、Iitsuka Takahiro、Yamauchi Takahira、Miura Akihiko、Pu Shenghong、Shirayama Yukihiko、Watanabe Ken、Duman Ronald S.、Kaneko Koichi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-017-08055-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10273
[Journal Article] Integrating neuroimmune systems in the neurobiology of depression2016
- Author(s)
  Eric S.Wohleb, Tina Franklin, Masaaki Iwata, Ronald S. Duman
- Journal Title
  
  Nature Reviews Neuroscience
  
  Volume: 未定
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19729
[Journal Article] Integrating neuroimmune systems in the neurobiology of depression2016
- Author(s)
  Eric S. Wohleb, Tina Franklin, Masaaki Iwata and Ronald S. Duman
- Journal Title
  
  NATURE REVIEWS NEUROSCIENCE
  
  Volume: 17 Issue: 8 Pages: 497-511
- DOI
  10.1038/nrn.2016.69
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19729
[Journal Article] Psychological Stress Activates the Inflammasome via Release of Adenosine Triphosphate and Stimulation of the Purinergic Type 2X7 Receptor.2015
- Author(s)
  Iwata M, Ota KT, Li XY, Sakaue F, Li N, Dutheil S, Banasr M, Duric V, Yamanashi T, Kaneko K, Rasmussen K, Glasebrook A, Koester A, Song D, Jones KA, Zorn S, Smagin G, Duman RS.
- Journal Title
  
  Biol Psychiatry
  
  Volume: 未定 Issue: 1 Pages: 12-22
- DOI
  10.1016/j.biopsych.2015.11.026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19729
[Journal Article] ミクログリアとストレス2014
- Author(s)
  岩田正明
- Journal Title
  
  分子精神医学
  
  Volume: 14 Pages: 11-18
- Data Source
  KAKENHI-PROJECT-25861006
[Presentation] 仕事の要求度―資源モデルの動機付けプロセスにおける性差に関する検討2023
- Author(s)
  福崎俊貴、岩田昇
- Organizer
  第96回日本産業衛生学会
- Data Source
  KAKENHI-PROJECT-23K02937
[Presentation] Commitment profiles among nurses: combinations of organizational commitment forms and work engagement, psychological distress, and turnover intention2023
- Author(s)
  FUKUZAKI Toshiki、TAKEDA Shinya、IWATA Noboru、OOBA Sawako、INOUE Masahiko
- Organizer
  17th International Congress of Behavioral Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K02937
[Presentation] The moderating role of five factor personalities on the relationship between job demands or resources and work engagement: A cross-sectional study2023
- Author(s)
  Fukuzaki Toshiki、Iwata Noboru
- Organizer
  Joint Congress of ICOH-WOPS & APA-PFAW 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K02937
[Presentation] onstruction of Screening System for Depression Used by Portable Terminal and Wearable Devices2019
- Author(s)
  Shigeki NAKAYAMA, Shinya TAKEDA, Masaaki IWATA
- Organizer
  9th World Congress of Behavioural and Cognitive Therapies
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09219
[Presentation] 炎症仮説に基づくうつ病の新たな治療の可能性2018
- Author(s)
  岩田正明
- Organizer
  第15回日本うつ病学会総会
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] うつ病・疼痛におけるインフラマソーム・ミクログリアを介した病態機構2018
- Author(s)
  岩田正明
- Organizer
  第40回日本生物学的精神医学会、第61回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] Intracerebral infusion of beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, produces antidepressant like effects in a rodent model of depression.2018
- Author(s)
  Kajitani N, Iwata M, Yamanashi T, Tsunetomi K, Miura A, Matsuo R, Nishiguchi T, Duman RS, Kaneko K.
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] 精神疾患の新しい創薬ターゲットを多角的に考察する：炎症仮説に基づくうつ病の新たな治療の可能性2018
- Author(s)
  岩田正明
- Organizer
  第114回日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] Beta-hydroxybutyrate ameliorates depressive like behavior induced by the social defeat stress2018
- Author(s)
  Tsunetomi K, Iwata M, Yamanashi T, Kajitani N, Nagata M, Miura A, Matsuo R, Nishiguchi T, Duman RS, Kaneko K.
- Organizer
  Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] うつ病の炎症性神経障害仮説2017
- Author(s)
  岩田正明
- Organizer
  第39会日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] Central infusion of beta-hydroxybutyrate produces antidepressant like effects in the a rodent model of depression.2017
- Author(s)
  Naofumi Kajitani, Masaaki Iwata, Takehiko Yamanashi, Akihiko Miura, Kyouhei Tsunetomi, Saki Fukuda, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Takahira Yamauchi, Ronald S. Duman, Koichi Kaneko
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] 免疫学的な知見から2017
- Author(s)
  岩田正明
- Organizer
  第27回日本臨床精神神経薬理学会
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] Oral administration of medium chain triglyceride produces antidepressant effects in rats via the elevation of beta-hydroxybutyrate.2017
- Author(s)
  Akihiko Miura, Masaaki Iwata, Takehiko Yamanashi, Naofumi Kajitani, Kyouhei Tsunetomi, Saki Fukuda, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Takahira Yamauchi, Ronald S. Duman, Koichi Kaneko
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] Beta-hydroxybutyrate, an endogenous NLRP3 inhibitor, ameliorates the activation of astrocyte in the rat hippocampus caused by immobilization stress.2017
- Author(s)
  Kyouhei Tsunetomi, Masaaki Iwata, Takehiko Yamanashi, Naofumi Kajitani, Akihiko Miura, Ryoichi Matsuo, Tsuyoshi Nishiguchi, Naho Kamiya, Saki Fukuda, Koichi Kaneko
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10273
[Presentation] うつ病治療の新たなターゲットとしてのNLRP3インフラマソーム2016
- Author(s)
  岩田正明、山梨豪彦、三浦明彦、梶谷直史、常冨恭平、山内崇平、神谷南帆、兼子幸一
- Organizer
  サイコグリア研究会
- Place of Presentation
  皆生グランドホテル天水（米子）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15K19729
[Presentation] 内因性NLRP3インフラマソーム阻害物質である βヒドロキシ酪酸の抗うつ効果の検討2016
- Author(s)
  山梨豪彦, 岩田正明, 神谷南帆, 常富恭平, 梶谷直史, 三浦明彦, 山内崇平, 兼子幸一
- Organizer
  日本神経精神薬理学会
- Place of Presentation
  COEX（ソウル）
- Year and Date
  2016-07-02
- Data Source
  KAKENHI-PROJECT-15K19729
[Presentation] Beta-hydroxybutyrate, endogenic NLRP3 inflammasome inhibitor, ameliorates neuro inflammation caused by stress.2016
- Author(s)
  Takehiko Yamanashi, Masaaki Iwata, Kyohei Tsunetomi, Naofumi Kajitani, Akihiko Miura, Ronald S. Duman, Koichi Kaneko
- Organizer
  Neuroscience meeting
- Place of Presentation
  San Diego Convention Center (San Diego)
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19729
[Presentation] うつ病治療の新たなターゲットとしてのNLRP3インフラマソーム2016
- Author(s)
  岩田正明
- Organizer
  日本生物学的精神医学会
- Place of Presentation
  福岡国際会議場（博多）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15K19729
[Presentation] ストレスが脳内炎症を介してうつ病を誘発する機序の解明と新たな治療法の開発2015
- Author(s)
  岩田正明
- Organizer
  第37回日本生物学的精神医学会
- Place of Presentation
  タワーホール船堀（東京都）
- Year and Date
  2015-09-24
- Data Source
  KAKENHI-PROJECT-15K19729
[Presentation] NLRP3 inflammasome is activated by psychological stress: mechanisms and novel drug targets2015
- Author(s)
  Takehiko Yamanashi, Masaaki Iwata, Naho Kamiya, Takahira Yamauchi, Ronald S. Duman, Koichi Kaneko
- Organizer
  Neuroscience 2015
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19729
[Presentation] Glutamate stimulates astrocyte release of ATP : a potential mechanism for riluzole’s antidepressant action
- Author(s)
  T.YAMANASHI, M.KUSUNOSE, T.YAMAUCHI, K.T.OTA, M.IWATA, R.S.DUMAN, K.KANEKO
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington D.C.
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25861006
[Presentation] ストレス誘発性グルタミン酸放出の抑制がリルゾールの持つ抗うつメカニズムである可能性
- Author(s)
  岩田正明、山梨豪彦、楠瀬未菜、山内崇平、三浦明彦、兼子幸一
- Organizer
  日本生物学的精神医学会
- Place of Presentation
  奈良県文化会館（奈良県奈良市）
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-25861006

1. NAKASO Kazuhiro (30379648)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. 竹田伸也 (00441569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. NAKAYAMA Shigeki (90300607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 吾郷由希夫 (50403027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 廣田颯香 (40876538)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 吉岡大祐 (20973267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 増本年男 (40715083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 鈴木康江 (10346348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 福崎俊貴 (80838764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

IWATA Masaaki 岩田 正明

Research Projects

Research Products

Co-Researchers

Clinical development of a novel, patient-optimized, inflammation-targeted antidepressantPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effects of smartphone use during the postpartum period on sleep and fatigue

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Cognitive Flexibility Test to Easily Assess Cognitive Impairment in Depression

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

βヒドロキシ酪酸の抗うつメカニズムの解明と炎症標的新規抗うつ薬としての臨床開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative dementia antibody therapy targeting microglial membrane proteins with few side effects

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identifing of common mechanisms of depression and cognitive decline associated with systemic diseases and application to treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of screening tool for subtype classification of depression

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel therapeutic strategy for mental disorders targeting NLRP3 inflammasomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigating the mechanisms of stress-induced depression via neuroinflammation and development of the new strategy for the treatment of depression.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Psychological stress activates the inflammasome via release of ATP and stimulation of the P2X7 receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Depression Frontier 22016

Author(s)

Total Pages

Publisher

Data Source

[Book] Depression Frontier 22016

Author(s)

Publisher

Data Source

[Journal Article] Commitment profiles among nurses: combinations of organizational commitment forms and work engagement, psychological distress, and turnover intention2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

IWATA Masaaki 岩田正明