MIZOSHITA Tsutomu 溝下勤

Researcher Number	40347414
Other IDs
Affiliation (based on the past Project Information) *help	2020: 名古屋市立大学, 医薬学総合研究院(医学), 研究員 2019: 名古屋市立大学, 医薬学総合研究院(医学), 講師 2016 – 2018: 名古屋市立大学, 大学院医学研究科, 講師 2011 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 助教 2008: Nagoya City University, 大学院医学研究科, 臨床研究医 … More 2007 – 2008: Nagoya City University, 大学院・医学研究科, 臨床研究医 2006: 名古屋市立大学, 大学院医学研究科, 臨床研修医 2004 – 2006: Aichi Cancer Center, Division of Oncological Pathology, Researcher, 腫瘍病理学部, 研究員 2004: 愛知県がんセンター研究所, 腫瘍病理学部, 研究員 2003: 愛知県がんセンター, 腫瘍病理学部, 研究員 Less
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Biological Sciences / Gastroenterology
Keywords	Principal Investigator 胃幹細胞 / in vitro 三次元培養腺管 / 形質発現 / 腸型形質 / 胃型形質 / in vitro三次元培養系 / 幹細胞 / 長期in vitro 三次元培養系 / 腸管ベーチェット病 / クローン病 … More / 潰瘍性大腸炎 / 炎症性腸疾患 / in vitro 三次元培養系 / in vitro三次元培養腺管 / 三次元培養系 / bone morphogenetic protein(BMP)-4 / 胃癌 / 小腸型 / 大腸型 / 上皮-間葉相互作用 / bone morphogenetic protein(BMP)-2 / 消化器癌 / 消化器学(食道,胃,小腸,大腸) / 前がん病変 / 腸型 / 胃型 / クロモグラニンA / 胃腸混合型 / 内分泌細胞 / 除菌 / Helicobacter pylori / スナネズミ / 胃がん … More Except Principal Investigator Helicobacter pylori / 胃がん / 食塩 / スナネズミ / 胃癌 / エピジェネティクス / Intestinal metaplasia / heterotopic proliferative gland / CagE / NF-kB / salt / promoter / Mongolian gerbil / 細胞分化マーカー / スナネズミホモログ遺伝子 / 可逆性病変 / スナネズミ腺胃発癌モデル / Updated Sydney System / 炎症 / 若年感染 / H. pylori / mutation / microdissection / スナネズミ腺胃発がんモデル / β-catenin / IL-1β / 腸上皮化生 / 異所性増殖性腺管 / Cag E / NF-κB / プロモーター / MUC6 / MUC5AC / 胃腺由来ムチン(GMCM) / 脱窩上皮由来ムチン(SMCM) / 胃表層粘膜層(SMGL) / 幹細胞 / 内分泌細胞 / 腸型 / 胃型 / 骨髄由来幹細胞 / Green mouse / Cox-2阻害剤 / etodolac / microsomal prostaglandin E2 synthase-1 / cyclooxygenase-2 Less

The development of in vitro carcinogenesis model, and the elucidation of mechanism of gastric and intestinal phenotypes aiming at the clinical applicationPrincipal Investigator
- Principal Investigator
  
  MIZOSHITA Tsutomu
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Epigenetic Mechanism Underlying Mucins in Gastric cancer
- Principal Investigator
  
  Hayashi Kazuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Molecular mechanism elucidation of gastric and intestinal differentiation and development of differentiation-inducing therapy against stem cellPrincipal Investigator
- Principal Investigator
  
  Mizoshita Tsutomu
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
The analysis of the shift from gastric to intestinal phenotype of stem cell in the stomach mucosaPrincipal Investigator
- Principal Investigator
  
  MIZOSHITA Tsutomu
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
The analyses of colon and small intestine specific transcription factors, and their expression in the cancers of the digestive tractPrincipal Investigator
- Principal Investigator
  
  MIZOSHITA Tsutomu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
ヘリコバクター・ピロリ感染による実験胃がんとその発症因子の解析
- Principal Investigator
  
  TATEMATSU Masae (立松正衛)
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Cancer Center Research Institute
ヘリコバクターピロリ除菌後発生胃がんのスナネズミモデルでの経時的検討Principal Investigator
- Principal Investigator
  
  溝下勤
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
  Aichi Cancer Center Research Institute
Gene alterations during stomach carciro genesis in H. pyrori infected Mongolian gerbik
- Principal Investigator
  
  TATEMATSU Masae
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Cancer Center

[Journal Article] Efficacies of first and second tumor necrosis factor inhibitors in refractory ulcerative colitis patients in real-world practice,2020
- Author(s)
  Marutani, Y., Mizoshita, T., Sugiyama, T., Togawa, S., Katano, T., Yamada, T., Hirata, Y., Kimura, Y., Miyaki, T., Inoue, Y., Suzuki, E., Sasaki, M., and Kataoka, H.
- Journal Title
  
  Indian J Gastroenterol.
  
  Volume: 39 Issue: 6 Pages: 565-575
- DOI
  10.1007/s12664-020-01092-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09355, KAKENHI-PROJECT-18K15759
[Journal Article] The efficacy of maintenance therapy after remission induction with tacrolimus in ulcerative colitis with and without previous tumor necrosis factor‐α inhibitor.2019
- Author(s)
  Suzuki T, Mizoshita T, Tanida S, Sugimura N, Katano T, Nishie H, Kataoka H.
- Journal Title
  
  JGH open
  
  Volume: in press Issue: 3 Pages: 217-223
- DOI
  10.1002/jgh3.12140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09355
[Journal Article] Real-world efficacy of adalimumab and infliximab for refractory intestinal Behçet's disease.2019
- Author(s)
  Sugimura N, Mizoshita T, Sugiyama T, Togawa S, Miyaki T, Suzuki T, Tanida S, Kataoka H, Sasaki M.
- Journal Title
  
  Dig Liver Dis.
  
  Volume: 51 Issue: 7 Pages: 967-971
- DOI
  10.1016/j.dld.2018.10.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09355
[Journal Article] Adalimumab Dose-Escalation Therapy Is Effective in Refractory Crohn’s Disease Patients with Loss of Response to Adalimumab, Especially in Cases without Previous Infliximab Treatment.2019
- Author(s)
  Suzuki T, Mizoshita T, Sugiyama T, Hirata Y, Kimura Y, Suzuki Y, Yamada T, Tsukamoto H, Mizushima T, Sugimura N, Katano T, Tanida S, Kataoka H, Sasaki M.
- Journal Title
  
  Case Rep Gastroenterol.
  
  Volume: 13 Issue: 1 Pages: 37-49
- DOI
  10.1159/000496453
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09355
[Journal Article] Prospective comparison of preference and efficacy of adalimumab and infliximab for treating ulcerative colitis naive to antitumor necrosis factor therapy2017
- Author(s)
  Mizoshita, T., Katano, T., Tanida, S., Hirano, A., Miyaki, T., Ozeki, K., Suzuki, Y., Sugimura, N., Kataoka, H. & Joh, T.
- Journal Title
  
  Medicine (Baltimore)
  
  Volume: 96 Issue: 32 Pages: e7800-e7800
- DOI
  10.1097/md.0000000000007800
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09355, KAKENHI-PROJECT-26460945
[Journal Article] Adalimumab therapy in a patient with Crohn's disease with a giant pelvic paraganglioma after chemotherapy.2017
- Author(s)
  Mizoshita T, Ando M, Sagawa H, Mori Y, Katano T, Ozeki K, Tanida S, Okamoto Y, Shimura T, Kubota E, Kataoka H, Kamiya T, Joh T.
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: in press Issue: 3 Pages: 250-254
- DOI
  10.1007/s12328-017-0726-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460945, KAKENHI-PROJECT-17K09355
[Journal Article] Long-Term Clinical Remission in Biologically Naïve Crohn's Disease Patients with Adalimumab Therapy, Including Analyses of Switch from Adalimumab to Infliximab.2016
- Author(s)
  Mizoshita T, Tanida S, Ozeki K, Katano T, Shimura T, Mori Y, Kubota E, Kataoka H, Kamiya T, Joh T.
- Journal Title
  
  Case Rep Gastroenterol.
  
  Volume: 10 Issue: 2 Pages: 283-91
- DOI
  10.1159/000445105
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460945
[Journal Article] Preventive effect of rebamipide on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats.2015
- Author(s)
  Tsukamoto H, Mizoshita T, Katano T, Hayashi N, Ozeki K, Ebi M, Shimura T, Mori Y, Tanida S, Kataoka H, Tsukamoto T, Tatematsu M, Joh T.
- Journal Title
  
  Toxicol Pathol.
  
  Volume: 67 Issue: 3 Pages: 271-277
- DOI
  10.1016/j.etp.2015.01.003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460945, KAKENHI-PROJECT-15K08960
[Journal Article] Gastric mesenchymal myofibroblasts maintain stem cell activity and proliferation of murine gastric epithelium in vitro.2015
- Author(s)
  Katano T, Ootani A, Mizoshita T, Tanida S, Tsukamoto H, Ozeki K, Kataoka H, Joh T
- Journal Title
  
  Am J Pathol.
  
  Volume: 185 Issue: 3 Pages: 798-807
- DOI
  10.1016/j.ajpath.2014.11.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460945
[Journal Article] Adalimumab treatment in intestinal Behçet's disease: Relationship with ectopic mucin 5AC glycoprotein expression and endoscopic improvement.2015
- Author(s)
  Mizoshita T, Tanida S, Joh T
- Journal Title
  
  Dig Liver Dis.
  
  Volume: 47 Issue: 11 Pages: 991-2
- DOI
  10.1016/j.dld.2015.07.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460945
[Journal Article] Adalimumab Treatment in Biologically Naïve Crohn's Disease : Relationship with Ectopic MUC5AC Expression and Endoscopic Improvement2014
- Author(s)
  Mizoshita, T., Tanida, S., Tsukamoto, H., Ozeki, K., Katano, T., Nishiwaki, H., Ebi, M., Mori, Y., Kubota, E., Kataoka, H., Kamiya, T., Joh, T
- Journal Title
  
  Gastroenterol Res Pract
  
  Volume: 2014 Pages: 687257-687257
- DOI
  10.1155/2014/687257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Maintenance of the remission stage of Crohn's disease with adalimumab therapy during pregnancy.2013
- Author(s)
  Mizoshita, T., Tanida, S., Tsukamoto, H., Ozeki, K., Katano, T., Ebi, M., Mori, Y., Kataoka, H., Kamiya, T., and Joh, T.
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 1049-53
- NAID
  130003365608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Establishment of a long-term three-dimensional primary culture of mouse glandular stomach epithelial cells within the stem cell niche.2013
- Author(s)
  Katano, T., Ootani, A., Mizoshita, T., Tanida, S., Tsukamoto, H., Ozeki, K., Ebi, M., Mori, Y., Kataoka, H., Kamiya, T., Toda, S., Joh, T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 432 Issue: 4 Pages: 558-563
- DOI
  10.1016/j.bbrc.2013.02.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921, KAKENHI-PROJECT-23591050
[Journal Article] Colon Mucosa Exhibits Loss of Ectopic MUC5AC Expression in Patients with Ulcerative Colitis Treated with Oral Tacrolimus.2013
- Author(s)
  Mizoshita, T., Tanida, S., Tsukamoto, H., Ozeki, K., Katano, T., Ebi, M., Mori, Y., Kataoka, H., Kamiya, T., and Joh, T.
- Journal Title
  
  ISRN Gastroenterol
  
  Volume: 2013 Pages: 304894-304894
- DOI
  10.1155/2013/304894
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Maintenance of the remission stage of Crohn's disease with adalimumab therapy during pregnancy2013
- Author(s)
  Mizoshita, T., Tanida, S., Tsukamoto, H., Ozeki, K., Katano, T., Ebi, M., Mori, Y., Kataoka, H., Kamiya, T., and Joh, T
- Journal Title
  
  Intern Med
  
  Volume: 52 Pages: 1049-53
- NAID
  130003365608
- URL
  https://www.jstage.jst.go.jp/article/internalmedicine/52/10/52_52.9466/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Adalimumab therapy following granulocyte and monocyte adsorptive apheresis in a patient with Crohn's disease accompanied by chronic myeloid leukemia.2012
- Author(s)
  Mizoshita, T., Tanida, S., Kusumoto, S., Ozeki, K., Tsukamoto, H., Ebi, M., Mori, Y., Kataoka, H., Kamiya, T., Joh, T.
- Journal Title
  
  Clin J Gastroenterol.
  
  Volume: 5 Pages: 302-306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Adalimumab therapy following granulocyte and monocyte adsorptive apheresis in a patient with Crohn's disease accompanied by chronic myeloid leukemia2012
- Author(s)
  Mizoshita, T., Tanida, S., Kusumoto, S., Ozeki, K., Tsukamoto, H., Ebi, M., Mori, Y., Kataoka, H., Kamiya, T., Joh, T
- Journal Title
  
  Clin J Gastroenterol
  
  Volume: 5 Pages: 302-306
- URL
  http://link.springer.com/article/10.1007%2Fs12328-012-0314-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Long-term high-dose proton pump inhibitor administration to Helicobacter pylori-infected Mongolian gerbils enhances neuroendocrine tumor development in the glandular stomach2011
- Author(s)
  Tsukamoto, H., Mizoshita, T., Sasaki, M., Mizushima, T., Tanida, S., Ozeki, K., Hirata, Y., Shimura, T., Kataoka, H., Kamiya, T., Nojiri, S., Tsukamoto, T., Tatematsu, M., Joh, T
- Journal Title
  
  Asian Pac J Cancer Prev
  
  Volume: 12 Pages: 1049-54
- URL
  http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:21790250&key=2011.12.4.1049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Long-term High-dose Proton Pump Inhibitor Administration to Helicobacter pylori-infected Mongolian gerbils Enhances Neuroendocrine tumor Development in the Glandular Stomach.2011
- Author(s)
  Tsukamoto H, Mizoshita T, Sasaki M, Mizushima T, Tanida S, Ozeki K, Hirata Y, Shimura T, Kataoka H, Kamiya T, Nojiri S, Tsukamoto T, Tatematsu M, Joh T.
- Journal Title
  
  Asian Pac J Cancer Prev.
  
  Volume: 12(4) Pages: 1049-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Lansoprazole induces collagenous colitis in the colon of Mongolian gerbils2011
- Author(s)
  Mizushima, T., Mizoshita, T., Sasaki, M., Tanida, S., Tsukamoto, H., Shimura, T., Kanematsu, T., Kataoka, H., Kamiya, T., Tsukamoto, T., Tatematsu, M., Joh, T
- Journal Title
  
  Asian Pac J Cancer Prev
  
  Volume: 12 Pages: 2759-62
- URL
  http://www.apocpcontrol.org/page/apjcp_issues_view.php?sid=Entrez:PubMed&id=pmid:22320988&key=2011.12.10.2759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Lansoprazole induces collagenous colitis in the colon of Mongolian gerbils.2011
- Author(s)
  Mizushima T, Mizoshita T, Sasaki M, Tanida S, Tsukamoto H, Shimura T, Kanematsu T, Kataoka H, Kamiya T, Tsukamoto T, Tatematsu M, Joh T.
- Journal Title
  
  Asian Pac J Cancer Prev.
  
  Volume: 12(10) Pages: 2759-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590921
[Journal Article] Gastric phenotypic expression and histogenesis of metachronous gastric cancers endoscopically resected2009
- Author(s)
  Mizoshita T, Kataoka H, Tanida S, Sasaki M, Ogasawara N, Kubota E, Wada T, Yamada T, Mori Y, Shimura T, Tsukamoto T, Tatematsu M, Joh T
- Journal Title
  
  Hepatogastroenterology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] An endocrine cell carcinoma with gastric-and-intestinal mixed phenotype adenocarcinoma component in the stomach2009
- Author(s)
  Mizoshita T, Kataoka H, Kubota E, Shimura T, Mori Y, Wada T, Ogasawara N, Sasaki M, Kamiya T, Sakamoto M, Akamo Y, Joh T
- Journal Title
  
  Digestive Endoscopy (in press)
- NAID
  10028186251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] An endocrine cell carcinoma with gastricandintestinal mixed phenotype adenocarcinoma component in the stomach2009
- Author(s)
  Mizoshita, T., et.al.
- Journal Title
  
  DigestiveEndoscopy (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Gastricandintestinal mixed endocrine cell phenotypi cexuression of carcinoid tumors in the Tectum2009
- Author(s)
  Hirata, Y., Mizoshita, T., et.al. (2番目)
- Journal Title
  
  Oncology Reports 21
  
  Pages: 107-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Gastric-and-intestinal mixed endocrine cell phenotypic expression of carcinoid tumors in the rectum2009
- Author(s)
  Hirata Y, Mizoshita T*, Mizushima T, Shimura T, Mori Y, Kubota E, Wada T, Ogasawara N, Tanida S, Kataoka H, Sasaki M, Kamiya T, Tsukamoto T, Tatematsu M, Joh T
- Journal Title
  
  Oncol Rep. 21
  
  Pages: 107-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Gastric phenotypic expression and histogenesis of met achronous,gastric cancers endoscopically resected2009
- Author(s)
  Mizoshita, T., et.al.
- Journal Title
  
  Hepatogastroenterology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Gastric phenotype signet-ring cell carcinoma of the stomach with multiple bone metastases effectively treated with sequential methotrexate and 5-fluorouracil2008
- Author(s)
  Mizoshita T, Kataoka H, Kubota E, Okamoto Y, Shimura T, Mori Y, Wada T, Ogasawara N, Sasaki M, Kamiya T, Joh T
- Journal Title
  
  Int. J Clin. Oncol. 13
  
  Pages: 373-376
- NAID
  10024302415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Gastric phenotypic expression and histogenesis of metachronous gastric cancers end oscopically resected2008
- Author(s)
  Mizoshita, T., et. al.
- Journal Title
  
  Hepatogastroenterology (In press)
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] A gastric phenotype signet-ring cell carcinoma of the stomach with multiple bone me tastasis effectively treated by sequential methotrexate and 5-fluorouracil therapy2008
- Author(s)
  Mizoshita, T., et. al.
- Journal Title
  
  Int.J Clin.Oncol (In press)
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Development of carcinoid tumors of the glandular stomach and effects of eradication in Helicobacter pylori-infected Mongolian gerbils2008
- Author(s)
  Cao L, Mizoshita T, Tsukamoto T, Takenaka Y, Toyoda T, Cao X, Ban H, Nozaki K, Tatematsu M
- Journal Title
  
  Asian Pac J Cancer Prev. 9
  
  Pages: 25-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Loss of MUC2 expression correlates with proyression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon.2007
- Author(s)
  Mizoshita, I., et al.
- Journal Title
  
  Histol Histopathol. 22・3
  
  Pages: 251-260
- Data Source
  KAKENHI-PROJECT-17790475
[Journal Article] Intestinal phenotypes of stomach cancers arising after Helicobacter pylori eradication in carcinogen-treated Mongolian gerbils2007
- Author(s)
  Mizoshita, T., et. al.
- Journal Title
  
  Asian Pac.J.Cancer Prev 8
  
  Pages: 267-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Intestinal phenotypes of stomach cancers arising after Helicobacter pylori eradication in carcinogen-treated Mongolian gerbils2007
- Author(s)
  Mizoshita T, Tsukamoto T, Toyoda T, Ban H, Nozaki K, Tatematsu M
- Journal Title
  
  Asian Pac J Cancer Prev 8
  
  Pages: 267-271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Effect of plaunotol in combination with clarithromycin against clarithromycin-resistant Helicobacter pylori in vitro and in vivo2007
- Author(s)
  Sasaki M, Mizoshita T, Mizushima T, Inoue H, Kamiya T, Kataoka H, Ogaswara N, Wada T, Kubota E, Mori Y, Shimura T, Hirata H, Ando K, Okamoto Y, Ohara H, Nakao H, Joh T
- Journal Title
  
  J Antimicrob Chemother 60
  
  Pages: 1060-1063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790490
[Journal Article] Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils2006
- Author(s)
  Mizoshita, T., et al.
- Journal Title
  
  Cancer Sci 97
  
  Pages: 38-44
- NAID
  10017103668
- Data Source
  KAKENHI-PROJECT-17790475
[Journal Article] Gastric and intestinal phenotypes and histogenesis of advanced glandular stomach cancers in carcinogen-treated, Helicobacter pylori-infected Mongolian gerbils.2006
- Author(s)
  Mizoshita, T., Tatematsu, M., et al.
- Journal Title
  
  Cancer Sci. 97(1)
  
  Pages: 38-44
- NAID
  10017103668
- Data Source
  KAKENHI-PROJECT-17013096
[Journal Article] Microsatellite instability is linked to loss of MLH1 expression in advanced gastric cancers : lack of a relationship with the histological type and phenotype2005
- Author(s)
  Mizoshita, T., et al.
- Journal Title
  
  Gastric Cancer 8
  
  Pages: 164-172
- Data Source
  KAKENHI-PROJECT-17790475
[Journal Article] Immunohistochemically detectable Cdx2 is present in intestinal phenotypic elements in early gastric cancers of both differentiated and undifferentiated types, with no correlation to non-neoplastic surrounding mucosa.Pathol Int.Tozaki K., et al.Helicobacter pylori-dependent NF-kappa B activation in newly established Mongolian gerbil gastric cancer cell lines.2005
- Author(s)
  Mizoshita, T., et al.
- Journal Title
  
  Cancer Sci. (in press)
- Data Source
  KAKENHI-PROJECT-12213164
[Journal Article] Role of Helicobacter pylori in the gastric carcinogenesis : The origin of gastric cancers and heterotopic proliferative glands in Mongolian gerbil.2005
- Author(s)
  Tatematsu M, Tsukamoto T, Mizoshita T
- Journal Title
  
  Helicobacter (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213164
[Journal Article] Colonic and small-intestinal phenotypes in gastric cancers : Relationships with clinicopathological findings2005
- Author(s)
  Mizoshita, T., et al.
- Journal Title
  
  Pathol Int 55
  
  Pages: 611-618
- NAID
  10017125700
- Data Source
  KAKENHI-PROJECT-17790475
[Journal Article] Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes.2005
- Author(s)
  Tsukamoto T, Mizoshita T, Mihara M, Tanaka H, Takenaka Y Yamamura Y, Nakamura S, Ushijima T, Tatematsu M
- Journal Title
  
  Histopathology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213164
[Journal Article] Beta- catenin gene alteration in glandular stomach adenocarcinomas in N-methyl-N-nitrosourea-treated and Helicobacter pylori-infected Mongolian gerbils.2004
- Author(s)
  Cao X, Tsukamoto T, Nozaki K, Mizoshita T, Ogasawara M, Tanaka H, Takenaka Y, Kaminishi M, Tatematsu M
- Journal Title
  
  Cancer Sci. 95
  
  Pages: 487-490
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213164
[Journal Article] Expression of Cdx2 and the phenotype of advanced gastric cancers : relationship with prognosis.2003
- Author(s)
  Mizoshita T, Tsukamoto T, Nakanishi H, Inada K, Ogasawara N, Joh T, ltoh M, Yamamura Y, Tatematsu M
- Journal Title
  
  J. Cancer Res. Clin. Oncol. 129
  
  Pages: 727-734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213164
[Journal Article] Synergistic Promoting Effects of Helicobacter pylori Infection and High-salt Diet on Gastric Carcinogenesis in Mongolian Gerbils.2002
- Author(s)
  Nozaki K, Shimizu N, Inada K, Tsukamoto T, Inoue M, Kumagai T, Sugiyama A, Mizoshita T, Kaminishi M, Tatematsu M:
- Journal Title
  
  Jpn.J.Cancer Res. 93
  
  Pages: 1083-1089
- NAID
  50000681772
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213164
[Presentation] 当院での高齢者の炎症性腸疾患（潰瘍性大腸炎、クローン病、腸管ベーチェット病）に対するbiologicsを含めた免疫抑制治療の現状2020
- Author(s)
  鈴木健人、溝下　勤、尾関啓司、谷田諭史、片岡洋望
- Organizer
  第16回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] Real-worldでの抗TNF-α抗体製剤による腸管ベーチェット病の治療 -多施設共同研究での検討-2020
- Author(s)
  溝下勤、杉村直美、杉山智哉、戸川昭三、宮木知克、鈴木健人、尾関啓司、谷田諭史、佐々木誠人、片岡洋望
- Organizer
  第16回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 集中治療室での治療を要した免疫チェックポイント阻害剤関連の重症薬剤性大腸炎2020
- Author(s)
  溝下　勤、志村貴也、片岡洋望
- Organizer
  第47回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 高齢者の炎症性腸疾患に対する生物学的製剤を含めた免疫抑制治療の検討2020
- Author(s)
  鈴木健人、溝下　勤、片野敬仁、尾関啓司、谷田諭史、片岡洋望
- Organizer
  第62回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] Real-worldでのベドリズマブの難治性潰瘍性大腸炎に対する寛解導入効果の検討2020
- Author(s)
  的屋　奨、溝下　勤、佐々木康成、稲垣勇輝、小林由花、成田幹誉人、柴田俊輔、岩井朋洋、安部快紀、宮木知克、佐野　仁
- Organizer
  第62回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] Golimumabを用いた難治性潰瘍性大腸炎の治療 -多施設後ろ向き研究での検討 -2020
- Author(s)
  鈴木絵里奈、溝下　勤、松田大知、的屋　奨、齋藤彰敏、鈴木健人、片岡洋望、小笹貴士
- Organizer
  第62回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 高齢者の難治性潰瘍性大腸炎に対する生物学的製剤及びタクロリムス治療の内視鏡的寛解率の検討 -安全性・大腸癌発生率も含めて-2019
- Author(s)
  溝下　勤、鈴木健人、尾関啓司、谷田諭史、片岡洋望
- Organizer
  第98回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] クローン病での生物学的製剤治療の現状 -高齢者と非高齢者の比較及びUstekinumab使用状況を含めて-2019
- Author(s)
  鈴木健人、溝下　勤、尾関啓司、谷田諭史、片岡洋望
- Organizer
  第61回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 抗TNF-α抗体製剤による難治性腸管ベーチェット病の治療 -後ろ向き多施設共同研究-2019
- Author(s)
  溝下勤、杉村直美、杉山智哉、戸川昭三、宮木知克、鈴木健人、尾関啓司、谷田諭史、佐々木誠人、片岡洋望
- Organizer
  第57回日本小腸学会学術集会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 抗TNF-α抗体製剤治療で粘膜治癒を達成した潰瘍性大腸炎症例での長期経過と大腸癌発生率についての検討 -内視鏡subscore 0と1の比較を含めて-2019
- Author(s)
  鈴木健人、溝下　勤、尾関啓司、谷田諭史、片岡洋望
- Organizer
  第98回日本消化器内視鏡学会総会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 難治性潰瘍性大腸炎での経口タクロリムス治療後の長期経過の検討 - 抗TNF-α抗体製剤治療歴の有無での比較解析を含めて -2019
- Author(s)
  鈴木健人、溝下　勤、谷田諭史、山田瑠里子、久野佳世子、市川　紘、奥田悠介、野尻優、杉村直美、尾関貴紀、北川美香、岩崎弘靖、西江裕忠、田中　守、尾関啓司、岡本泰幸、志村貴也、久保田英嗣、神谷　武、片岡洋望
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 3つの抗TNFα抗体製剤（Infliximab、Adalimumab、Golimumab）による難治性潰瘍性大腸炎の治療 -スイッチ例を含めた検討2018
- Author(s)
  鈴木祐香、溝下　勤、杉山智哉、山田智則、平田慶和、木村吉秀、遠藤雅行、戸川　昭三、鈴木健人、杉村直美、尾関啓司、谷田諭史、片岡洋望、佐々木誠人
- Organizer
  第60回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 当院での抗TNF-α抗体製剤（Adalimumab、Infliximab）による腸管ベーチェット病の治療2018
- Author(s)
  溝下　勤、片野敬仁、尾関啓司、谷田諭史、鈴木健人、市川　紘、野尻　優、岩崎弘靖、稲垣佑祐、田中　守、西江裕忠、岡本泰幸、志村貴也、久保田英嗣、片岡洋望、神谷　武、城　卓志
- Organizer
  第14回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] Adalimumabへの二次無効を呈したクローン病症例でのAdalimumab倍量投与の有効性の検討2018
- Author(s)
  鈴木健人、溝下　勤、杉山智哉、平田慶和、木村吉秀、鈴木祐香、山田智則、塚本宏延、水島隆史、杉村直美、片野敬仁、尾関啓司、谷田諭史、片岡洋望、佐々木誠人
- Organizer
  第60回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 当院での抗TNF-α抗体製剤（Adalimumab、Infliximab）による腸管ベーチェット病の治療2018
- Author(s)
  溝下　勤、片野敬仁、尾関啓司、谷田諭史、鈴木健人、市川　紘、野尻　優、岩崎弘靖、稲垣佑祐、田中　守、西江裕忠、岡本泰幸、志村貴也、久保田英嗣、片岡洋望、神谷　武、城　卓志
- Organizer
  第14回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] 難治性クローン病でのアダリムマブ倍量投与の寛解導入・維持に関する検討2018
- Author(s)
  鈴木健人、溝下　勤、杉山智哉、平田慶和、木村吉秀、塚本宏延、水島隆史、杉村直美、尾関啓司、谷田諭史、佐々木誠人、片岡洋望
- Organizer
  第46回日本潰瘍学会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] Adalimumab倍量投与を行った難治性クローン病症例での寛解導入効果を含めた臨床的検討2018
- Author(s)
  鈴木健人、溝下勤、谷田諭史、尾関啓司、片野敬仁、市川紘、野尻優、北川美香、稲垣佑祐、岩崎弘靖、田中守、西江裕忠、岡本泰幸、志村貴也、久保田英嗣、片岡洋望、杉山智哉、佐々木誠人、城卓志
- Organizer
  第104回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 腸管ベーチェット病に対する抗TNF-α抗体製剤治療の現状と有効性に関する検討2018
- Author(s)
  杉村直美、溝下　勤、杉山智哉、戸川昭三、宮木知克、鈴木健人、尾関啓司、谷田諭史、岡本泰幸、志村貴也、久保田英嗣、片岡洋望、神谷　武、佐々木　誠人
- Organizer
  第60回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 抗TNF-α抗体製剤（インフリキシマブ/アダリムマブ）を導入した潰瘍性大腸炎症例での内視鏡的粘膜治癒率の解析を目的とした前向き研究 -薬剤選択理由のアンケート調査を含めて -2017
- Author(s)
  溝下　勤、谷田諭史、平野敦之、宮木知克、片野敬仁、尾関啓司、片岡洋望、城　卓志
- Organizer
  第59回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] 抗TNF-α抗体製剤（インフリキシマブ/アダリムマブ）を導入した潰瘍性大腸炎症例での内視鏡的粘膜治癒率の解析を目的とした前向き研究 -薬剤選択理由のアンケート調査を含めて -2017
- Author(s)
  溝下　勤、谷田諭史、平野敦之、宮木知克、片野敬仁、尾関啓司、片岡洋望、城　卓志
- Organizer
  第59回日本消化器病学会大会
- Data Source
  KAKENHI-PROJECT-17K09355
[Presentation] 抗TNF-α抗体製剤での薬物治療最適化を目指した潰瘍性大腸炎症例での前向き研究　-　薬剤選択理由のアンケート調査を含めて　-2017
- Author(s)
  溝下　勤、谷田諭史、平野敦之、宮木知克、尾関啓司、片野敬仁、片岡洋望、城　卓志
- Organizer
  第13回日本消化管学会総会学術集会
- Place of Presentation
  名古屋国際会議場（愛知県、名古屋市）
- Year and Date
  2017-02-18
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] 2つの抗TNF-α抗体製剤（adalimumab、infliximab）の内視鏡的粘膜治癒率の解析を目的とした潰瘍性大腸炎症例での前向き研究 -薬剤選択理由のアンケート調査を含めて -2016
- Author(s)
  溝下　勤、谷田諭史、平野敦之、宮木知克、尾関啓司、片野敬仁、片岡洋望、城　卓志
- Organizer
  第58回日本消化器病学会大会（第24回　日本消化器関連学会週間）
- Place of Presentation
  神戸コンベンションセンター（兵庫県、神戸市）
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] Adalimumabを1st anti-TNF-α monoclonal antibodyとして投与したクローン病の長期経過 -infliximabへのスイッチ例でのトラフ値測定も含めて -2016
- Author(s)
  溝下　勤、尾関啓司、片野敬仁、谷田諭史、野村智史、稲垣佑祐、林　則之、西江裕忠、志村貴也、森　義徳、久保田英嗣、片岡洋望、神谷　武、城　卓志
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  京王プラザホテル（東京都、新宿区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] 腸管ベーチェット病に対するadalimumab治療－胃型ムチンコア蛋白MUC5ACの発現を含めて－2016
- Author(s)
  溝下　勤、谷田諭史、尾関啓司、片野敬仁、稲垣佑祐、林　則之、西江裕忠、森　義徳、久保田英嗣、片岡洋望、神谷　武、城　卓志
- Organizer
  第12回日本消化管学会総会学術集会
- Place of Presentation
  東京（京王プラザホテル）
- Year and Date
  2016-02-26
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] 炎症性腸疾患の疾患活動性マーカーの解析 -粘膜治癒を目指す治療におけるMUC5ACの有用性-2015
- Author(s)
  溝下　勤、谷田諭史、尾関啓司、塚本宏延、片野敬仁、片岡洋望、城　卓志
- Organizer
  第11回日本消化管学会総会学術集会
- Place of Presentation
  京王プラザホテル（東京都・新宿区）
- Year and Date
  2015-02-13
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] Adalimumabを用いたintestinal Behçet's diseaseの治療－12か月以上経過を追えた5症例での臨床病理学的検討－2015
- Author(s)
  溝下　勤、谷田諭史、塚本宏延、尾関啓司、片野敬仁、林　則之、田中　守、西脇裕高、澤田　武、森　義徳、久保田英嗣、片岡洋望、神谷　武、城　卓志
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台（仙台国際センター）
- Year and Date
  2015-04-24
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] Crohn's diseaseの腸粘膜でのMUC5AC異所性発現－内視鏡所見との比較検討－2015
- Author(s)
  溝下　勤、尾関　啓司、塚本　宏延、谷田　諭史、片野　敬仁、稲垣　佑祐、林　則之、　田中　守、西脇　裕高、澤田　武、森　義徳、久保田　英嗣、片岡　洋望、神谷　武、城　卓志
- Organizer
  第57回日本消化器病学会大会（第23回　日本消化器関連学会週間）
- Place of Presentation
  東京（グランドプリンスホテル新高輪）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] Crohn's diseaseでの疾患活動性マーカーの検討 - Adalimumabを投与したbiologic naive症例でのムチンコア蛋白MUC5ACの発現2014
- Author(s)
  溝下　勤、塚本宏延、尾関啓司、谷田諭史、片野敬仁、林　則之、田中守、西脇裕高、海老正秀、澤田　武、森　義徳、久保田英嗣、片岡洋望、神谷　武、城　卓志
- Organizer
  第56回　日本消化器病学会大会
- Place of Presentation
  神戸国際展示場（兵庫県・神戸市）
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] Stem cell nicheを用いたin vitro胃腺管3次元培養系の確立2014
- Author(s)
  片野敬仁、溝下　勤、城　卓志
- Organizer
  第100回　消化器病学会総会
- Place of Presentation
  東京国際フォーラム（東京都・千代田区）
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] 幹細胞機能を保持する正常胃腺管3次元培養系を用いた間質myofibroblastの機能解析2014
- Author(s)
  片野敬仁，溝下　勤，城　卓志．
- Organizer
  第56回　日本消化器病学会大会
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26460945
[Presentation] Adalimumabを投与したbiologic naive Crohn's disease症例の臨床的検討2014
- Author(s)
  溝下勤, 谷田諭史, 尾関啓司, 塚本宏延, 片野敬仁, 林則之, 田中守, 濱野真吾, 西脇裕高, 海老正秀, 澤田武, 森義徳, 久保田英嗣, 片岡洋望, 城卓志
- Organizer
  第10回日本消化管学会総会学術集会, 口演(一般演題, オーラルセッション9)
- Place of Presentation
  福島(コラッセふくしま)
- Year and Date
  2014-02-14
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] Long-term three-dimensional primary gastric culture under an air-liquid interface environment2013
- Author(s)
  Katano, T., Mizoshita, T., Joh, T
- Organizer
  21th United European Gastroenterology Week
- Place of Presentation
  Germany(Berlin)
- Year and Date
  2013-10-14
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] 当院でのbiologic naive Crohn's diseaseに対するadalimumab治療2013
- Author(s)
  溝下勤, 谷田諭史, 尾関啓司, 塚本宏延, 城卓志
- Organizer
  第9回日本消化管学会総会学術集会, IBD臨床4一般演題オーラルセッション27
- Place of Presentation
  東京(京王プラザホテル)(O27-4)
- Year and Date
  2013-01-26
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] ムチンコア蛋白MUC5ACは潰瘍性大腸炎の疾患活動性マーカーとして有用である-Tacrolimusを導入した中等症・重症例での検討-2013
- Author(s)
  溝下勤, 谷田諭史, 尾関啓司, 塚本宏延, 片野敬仁, 林則之, 田中守, 濱野真吾, 西脇裕高, 海老正秀, 森義徳, 久保田英嗣, 片岡洋望, 城卓志
- Organizer
  第55回日本消化器病学会大会(第21回日本消化器関連学会週間)
- Place of Presentation
  東京(品川プリンスホテル)(示説大腸(潰瘍性大腸炎1))
- Year and Date
  2013-10-10
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] スナネズミはlansoprazole-associated collagenous colitis解析モデルとして有用である2012
- Author(s)
  溝下勤, 塚本宏延, 谷田諭史, 尾関啓司, 城卓志
- Organizer
  第49回日本消化器免疫学会総会
- Place of Presentation
  鹿児島(城山観光ホテル)(一般口演(一般演題, 消化管1))
- Year and Date
  2012-07-05
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] Biologic naïve Crohn's diseaseに対するadalimumab治療-名古屋市立大学病院での検討-2012
- Author(s)
  溝下勤, 谷田諭史, 塚本宏延, 尾関啓司, 水島隆史, 城卓志
- Organizer
  第8回日本消化管学会総会学術集会
- Place of Presentation
  仙台(仙台国際センター)(口演(ポスター, ポスターセッション22症例報告13, P-22-3))
- Year and Date
  2012-02-10
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] Tacrolimus・顆粒球単球吸着(GMA)併用療法による中等症・重症潰瘍性大腸炎症例への寛解導入の試み–当院での検討-2012
- Author(s)
  溝下勤, 谷田諭史, 尾関啓司, 塚本宏延, 城卓志
- Organizer
  第54回日本消化器病学会大会(第20回日本消化器関連学会週間)
- Place of Presentation
  神戸(神戸国際展示場)(示説{大腸(潰瘍性大腸炎)6})
- Year and Date
  2012-10-11
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] ランソプラゾール持続投与が胃腫瘍発生に与える影響 -スナネズミモデルでの検討2011
- Author(s)
  溝下　勤、佐々木誠人、谷田諭史、志村貴也、森　義徳、片岡洋望、神谷　武、城　卓志
- Organizer
  第22回日本消化器癌発生学会総会
- Place of Presentation
  佐賀（ホテルニューオータニ佐賀）
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] ランソプラゾール持続投与が胃腫瘍発生に与える影響–スナネズミモデルでの検討2011
- Author(s)
  溝下勤, 佐々木誠人, 谷田諭史, 志村貴也, 森義徳, 片岡洋望, 神谷武, 城卓志
- Organizer
  第22回日本消化器癌発生学会総会
- Place of Presentation
  佐賀(ホテルニューオータニ佐賀)(一般口演)
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] 高齢者の潰瘍性大腸炎患者の治療-名古屋市立大学病院の現状-(ワークショップ13高齢者における消化器疾患の診断と治療)2011
- Author(s)
  溝下勤, 谷田諭史, 城卓志
- Organizer
  第53回日本消化器病学会大会(第19回日本消化器関連学会週間), ワークショップ
- Place of Presentation
  福岡(福岡サンパレスパレスルーム)
- Year and Date
  2011-10-22
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] 6か月間のランソプラゾール持続投与がHelicobacter pylori感染スナネズミ腺胃粘膜および血清ガストリン値に与える影響,(口演)2009
- Author(s)
  溝下勤,佐々木誠人,水島隆史,神谷武,片岡洋望,谷田諭史,小笠原尚高,和田恒哉,久保田英嗣,志村貴也,平田慶和,城卓志
- Organizer
  第5回日本消化管学会総会学術集会
- Place of Presentation
  東京(京王プラザホテル)
- Year and Date
  2009-02-13
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] 胃癌の胃型・腸型形質発現から見た組織発生-除菌後発生例および異時性多発例-,(ミニシンポジウム2発癌機構(食道・胃)2008
- Author(s)
  溝下勤,片岡洋望,谷田諭史,久保田英嗣,志村貴也,塚本徹哉,立松正衞,城卓志
- Organizer
  第19回日本消化器癌発生学会総会
- Place of Presentation
  大分(別府亀の井ホテル)
- Year and Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] 多発骨転移を伴う胃癌-胃型・腸型形質発現を検索した2症例での検討-,(示説)2008
- Author(s)
  溝下勤,片岡洋望,谷田諭史,志村貴也,城卓志
- Organizer
  第46回日本癌治療学会総会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2008-11-01
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] 胃型・腸型形質発現およびマイクロサテライト不安定性から見た胃癌の自然史,(ワークショップ5消化管癌の自然史を見直す)2008
- Author(s)
  溝下勤,片岡洋望,城卓志
- Organizer
  第94回日本消化器病学会総会
- Place of Presentation
  福岡(福岡国際会議場)
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] The gastric and intestinal mucinous phenotypes of gastric cancers in human and Helicobacter pylori-infected and -eradicated Mongolian gerbils, (Oral)2008
- Author(s)
  Tsutomu Mizoshita, Hiromi Kataoka, Makoto Sasaki, Takaya Shimura, Yoshinori Mori, Eiji Kubota, Tsuneya Wada, Naotaka Ogasawara, Takeshi Kamiya, Takashi Joh
- Organizer
  Annual Meeting of the American Gastrointestinal Association, Digestive Disease Week
- Place of Presentation
  San Diego (San Diego Convention Center), U.S.A.
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] 胃型・腸型形質発現およびマイクロサテライト不安定性から見た胃癌の自然史2008
- Author(s)
  溝下勤, 片岡洋望, 城卓志
- Organizer
  第94回日本消化器病学会総会(ワークショップ5消化管癌の自然史を見直す)
- Place of Presentation
  福岡(福岡国際会議場)
- Year and Date
  2008-05-10
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] 胃腸混合型の腺癌成分を伴った胃内分泌細胞癌の1例,(口演)2008
- Author(s)
  溝下勤,片岡洋望,佐々木誠人,神谷武,谷田諭史,小笠原尚高,久保田英嗣,和田恒哉,志村貴也,水島隆史,平田慶和,城卓志
- Organizer
  日本消化器病学会東海支部第108回例会
- Place of Presentation
  岐阜(長良川国際会議場)
- Year and Date
  2008-06-28
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] プロトンポンプインヒビター持続投与による胃粘膜および血清ガストリン値の変化-スナネズミモデルでの検討-,(示説)2008
- Author(s)
  溝下勤,佐々木誠人,水島隆史,神谷武,片岡洋望,谷田諭史,小笠原尚高,和田恒哉,久保田英嗣,志村貴也,平田慶和,城卓志
- Organizer
  第50回日本消化器病学会大会(第16回日本消化器関連学会週間)
- Place of Presentation
  東京(グランドプリンスホテル新高輪)
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] スナネズミモデルで発生したHelicobacter pylori除菌後発生胃癌の胃型・腸型形質発現,(口演)2008
- Author(s)
  溝下勤,片岡洋望,佐々木誠人,神谷武,小笠原尚高,久保田英嗣,和田恒哉,森義徳,志村貴也,塚本徹哉,立松正衞,城卓志
- Organizer
  第4回日本消化管学会総会学術集会
- Place of Presentation
  大阪(グランキューブ大阪)
- Year and Date
  2008-02-07
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] 骨髄癌症を合併した胃印環細胞癌の1例,(口演)2008
- Author(s)
  溝下勤,佐々木誠人,片岡洋望,神谷武,小笠原尚高,久保田英嗣,和田恒哉,志村貴也,岡本泰幸,城卓志
- Organizer
  第204回日本内科学会東海地方会
- Place of Presentation
  名古屋(名古屋国際会議場)
- Year and Date
  2008-02-16
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] The phenotypes of stomach cancers arising after Helicobacter pylori eradication in carcinogen-treated Mongolian gerbils, (Workshops 2 Experimental animal models and genetically-engineered animals, 2-2 Animal model for carcinogenesis)2007
- Author(s)
  Tsutomu Mizoshita, Tetsuya Tsukamoto, Takeshi Toyoda, Hiromi Kataoka, Makoto Sasaki, Eiji Kubota, Yoshinori Mori, Takaya Shimura, Takashi Joh, Masae Tatematsu
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2007-10-03
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] Helicobacter pylori感染と胃癌の形質発現-ヒトおよびスナネズミモデルでの検討-,(シンポジウム1胃癌におけるHelicobacter pylori感染-基礎的・臨床的研究のその後-)2007
- Author(s)
  溝下勤,片岡洋望,城卓志
- Organizer
  第93回日本消化器病学会総会
- Place of Presentation
  青森(青森市文化会館)
- Year and Date
  2007-04-19
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] 大腸腺腫・早期大腸癌でのムチン関連蛋白(MUC2、MUC5AC)とCdx2の発現,(示説)2007
- Author(s)
  溝下勤,片岡洋望,佐々木誠人,神谷武,小笠原尚高,久保田英嗣,和田恒哉,森義徳,志村貴也,水島隆史,岡本泰幸,塚本徹哉,立松正衞,城卓志
- Organizer
  第49回日本消化器病学会大会(第15回日本消化器関連学会週間)
- Place of Presentation
  神戸(神戸国際展示場)
- Year and Date
  2007-10-19
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] 多発骨転移で発見された胃型胃癌の1例,(口演)2007
- Author(s)
  溝下勤,片岡洋望,佐々木誠人,志村貴也,岡本泰幸,神谷武,小笠原尚高,久保田英嗣,和田恒哉,森義徳,水島隆史,平田慶和,城卓志
- Organizer
  日本消化器病学会東海支部第107回例会
- Place of Presentation
  名古屋(名古屋市中小企業振興会館)
- Year and Date
  2007-11-17
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] Helicobacter pylori除菌後発生胃癌の形質発現-スナネズミモデルおよびヒトでの検討-,(シンポジウム2除菌後胃癌の特徴)2007
- Author(s)
  溝下勤,塚本徹哉,佐々木誠人,城卓志,立松正衞
- Organizer
  第13回日本ヘリコバクター学会学術集会
- Place of Presentation
  大津(琵琶湖ホテル)
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-19790490
[Presentation] スナネズミはlansoprazole-associated collagenous colitis解析モデルとして有用である
- Author(s)
  溝下　勤、塚本宏延、谷田諭史、尾関啓司、城　卓志
- Organizer
  日本消化器免疫学会総会
- Place of Presentation
  城山観光ホテル（鹿児島）
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] Long-term three-dimensional primary gastric culture under an air-liquid interface environment.
- Author(s)
  Takahito Katano、Tsutomu Mizoshita、Takashi Joh
- Organizer
  21th United European Gastroenterology Week
- Place of Presentation
  Berlin (Germany)
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] ムチンコア蛋白MUC5ACは潰瘍性大腸炎の疾患活動性マーカーとして有用である -Tacrolimusを導入した中等症・重症例での検討-
- Author(s)
  溝下　勤、谷田諭史、尾関啓司、塚本宏延、片野敬仁、林　則之、田中守、濱野真吾、西脇裕高、海老正秀、森　義徳、久保田英嗣、片岡洋望、城　卓志
- Organizer
  第55回　日本消化器病学会大会（第21回　日本消化器関連学会週間）
- Place of Presentation
  東京（品川プリンスホテル）
- Data Source
  KAKENHI-PROJECT-23590921
[Presentation] Adalimumabを投与したbiologic naive Crohn's disease症例の臨床的検討
- Author(s)
  溝下　勤、谷田諭史、尾関啓司、塚本宏延、片野敬仁、林　則之、田中守、濱野真吾、西脇裕高、海老正秀、澤田武、森　義徳、久保田英嗣、片岡洋望、城　卓志
- Organizer
  第10回日本消化管学会総会学術集会
- Place of Presentation
  福島（コラッセふくしま）
- Data Source
  KAKENHI-PROJECT-23590921

1. JOH Takashi (30231369)

# of Collaborated Projects: 3 results

# of Collaborated Products: 46 results
2. TATEMATSU Masae (70117836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. TSUKAMOTO Tetsuya (00236861)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. IKEHARA Yuzuru (10311440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TANIDA Satoshi (30528782)

# of Collaborated Projects: 2 results

# of Collaborated Products: 38 results
6. Hayashi Kazuki (00405200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 稲田健一 (70246081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 中西速夫 (20207830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 岡本泰幸 (60444973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 片野敬仁 (50768372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results

MIZOSHITA Tsutomu 溝下 勤

Research Projects

Research Products

Co-Researchers

The development of in vitro carcinogenesis model, and the elucidation of mechanism of gastric and intestinal phenotypes aiming at the clinical applicationPrincipal Investigator

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Epigenetic Mechanism Underlying Mucins in Gastric cancer

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Molecular mechanism elucidation of gastric and intestinal differentiation and development of differentiation-inducing therapy against stem cellPrincipal Investigator

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The analysis of the shift from gastric to intestinal phenotype of stem cell in the stomach mucosaPrincipal Investigator

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The analyses of colon and small intestine specific transcription factors, and their expression in the cancers of the digestive tractPrincipal Investigator

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ヘリコバクター・ピロリ感染による実験胃がんとその発症因子の解析

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ヘリコバクターピロリ除菌後発生胃がんのスナネズミモデルでの経時的検討Principal Investigator

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Gene alterations during stomach carciro genesis in H. pyrori infected Mongolian gerbik

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[Journal Article] Efficacies of first and second tumor necrosis factor inhibitors in refractory ulcerative colitis patients in real-world practice,2020

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[Journal Article] The efficacy of maintenance therapy after remission induction with tacrolimus in ulcerative colitis with and without previous tumor necrosis factor‐α inhibitor.2019

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[Journal Article] Real-world efficacy of adalimumab and infliximab for refractory intestinal Beh&ccedil;et's disease.2019

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[Journal Article] Adalimumab Dose-Escalation Therapy Is Effective in Refractory Crohn’s Disease Patients with Loss of Response to Adalimumab, Especially in Cases without Previous Infliximab Treatment.2019

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[Journal Article] Prospective comparison of preference and efficacy of adalimumab and infliximab for treating ulcerative colitis naive to antitumor necrosis factor therapy2017

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[Journal Article] Adalimumab therapy in a patient with Crohn's disease with a giant pelvic paraganglioma after chemotherapy.2017

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MIZOSHITA Tsutomu 溝下勤

[Journal Article] Real-world efficacy of adalimumab and infliximab for refractory intestinal Behçet's disease.2019

[Journal Article] Long-Term Clinical Remission in Biologically Naïve Crohn's Disease Patients with Adalimumab Therapy, Including Analyses of Switch from Adalimumab to Infliximab.2016

[Journal Article] Adalimumab treatment in intestinal Behçet's disease: Relationship with ectopic mucin 5AC glycoprotein expression and endoscopic improvement.2015