Yamaori Satoshi 山折大

… Alternative Names

YAMAORI Satoshi 山折大

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Researcher Number	40360218
Other IDs
External Links
Affiliation (Current)	2025: 東京薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2021: 東京薬科大学, 薬学部, 教授 2014 – 2020: 信州大学, 学術研究院医学系(医学部附属病院), 准教授 2012 – 2013: 信州大学, 医学部附属病院, 准教授 2009 – 2011: Hokuriku University, 薬学部, 助教 2003 – 2005: 北陸大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Environmental pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Environmental and hygienic pharmacy Except Principal Investigator Medical pharmacy / Environmental pharmacy / Biological pharmacy
Keywords	Principal Investigator 大麻 / 分子毒性学 / 異物代謝 / 中毒学 / 阻害作用 / CYP3A4 / CYP2D6 / CYP2C9 / CYP1A2 / 抗腫瘍効果 … More / 分子標的薬 / CYP2J2 / 降圧薬 / 発現解析 / 薬物代謝酵素 / 胎児毒性 / ヒト胎児肝細胞 / 酵素阻害 / シトクロムP450 / カンナビノイド / 発現誘導 / HepG2細胞 / 非幻覚成分 / A549細胞 / PTK / AhR / HeG2細胞 / ヒトCYP1A1 / カンナビジオール / フィトカンナビノイド / マクロファージ腫瘍細胞 / 神経芽細胞腫 / CP-55940 / CHO-K1細胞 / カンナビノイド受容体 / 細胞毒性 / J774-1マクロファージ / C-1300N18神経細胞 / テトラヒドロカンナビノール … More Except Principal Investigator テトラヒドロカンナビノール / カンナビノイド / 薬物代謝酵素 / グルココルチコイド受容体 / エピジェネティクス / 発現調節因子 / 発現制御 / CYP3A7 / SULT1E1 / 糖質コルチコイド / ヒト胎児肝細胞 / hypothermia / catalepsy / tolerance development / pharmacological effect / 2-arachidonoylglycerol / anandamide / endogenous cannabinoid / tetrahydrocannabinol / 体温下降作用 / カタレプシー / 耐性発現 / 薬理効果 / 水解酵素 / 2-アラキドノイルグリセロール / アナンダミド / 内因性カンナビノイド / central nervous system / uridine receptor / nucleoside / antinociceptive effect / sleep / uridine / 中枢抑制系 / ウリジン受容体 / ヌクレオシド / 鎮痛 / 睡眠 / ウリジン / ヒトES細胞 / 胆管上皮細胞 / 分化誘導 / 低分子化合物 / 腸管上皮細胞 / 肝細胞 / iPS細胞 / ヒト人工多能性幹細胞 / 代謝学 / 薬物動態 / 大麻 / 乳がん / 大麻草 / グルクロン酸抱合 / 構造活性相関 / 細胞毒性 / 酵素誘導 / 酵素阻害 / LOX / COX / シトクロムP450 Less

Exploration of drugs to potently and selectively inhibit human CYP2J2 activity and evaluation of their antitumor effect on human tumor cell linesPrincipal Investigator
- Principal Investigator
  
  YAMAORI Satoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Shinshu University
Elucidation of mechanisms underlying different glucocorticoid responses of drug-metabolizing enzymes, SULT1E1 and CYP3A7, in human fetal liver cells
- Principal Investigator
  
  OHMORI Shigeru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
Estimation of fetotoxicity of chemical compounds with human fetal liver cells and molecular basis of their toxicitiesPrincipal Investigator
- Principal Investigator
  
  YAMAORI Satoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Shinshu University
Mechanisms underlying inhibition of human cytochrome P450 enzymesby major phytocannabinoidsPrincipal Investigator
- Principal Investigator
  
  YAMAORI Satoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Shinshu University
  Hokuriku University
Differentiation ofhuman iPS cells into hepatocytes and bile duct epithelial cells and application to drug development study
- Principal Investigator
  
  OHMORI Shigeru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Shinshu University
Mechanism underlying induction of human CYP1A1 gene by major phytocannabinoidsPrincipal Investigator
- Principal Investigator
  
  YAMAORI Satoshi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Molecular mechanism for interaction of major cannabinoids with enzyme system
- Principal Investigator
  
  WATANABE Kazuhito
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Preventive pharmaceutical research for the appropriate use of the principal marijuana constituent in clinical contexts
- Principal Investigator
  
  TAKEDA Shuso
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Hokuriku University
大麻成分カンナビノイド活性代謝物の細胞毒性発現機構の解明Principal Investigator
- Principal Investigator
  
  山折大
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Involvement of endogenous cannabinoids in the pharmacological effects of cannabinoids
- Principal Investigator
  
  WATANABE Kazuhito
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Hokuriku University
Hypnotic and antinociceptive effects of N3-substituted oxopyrimidines and their mechanism
- Principal Investigator
  
  KIMURA Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokuriku University

[Journal Article] Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells2020
- Author(s)
  Shusuke Ozawa, Satoshi Yamaori, Kaori Aikawa, Shinobu Kamijo, Shigeru Ohmori
- Journal Title
  
  Life Sciences
  
  Volume: 258 Pages: 118140-118140
- DOI
  10.1016/j.lfs.2020.118140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07063
[Journal Article] Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: potent inhibition by azelnidipine and manidipine2019
- Author(s)
  Noriaki Ikemura, Satoshi Yamaori, Chinatsu Kobayashi, Shinobu Kamijo, Norie Murayama, Hiroshi Yamazaki, Shigeru Ohmori
- Journal Title
  
  Chemico-Biological Interactions
  
  Volume: 306 Pages: 1-9
- DOI
  10.1016/j.cbi.2019.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07063, KAKENHI-PROJECT-17K08426
[Journal Article] A Specific Probe Substrate for Evaluation of CYP4A11 Activity in Human Tissue Microsomes and a Highly Selective CYP4A11 Inhibitor: Luciferin-4A and Epalrestat2018
- Author(s)
  Yamaori Satoshi、Araki Noriyuki、Shionoiri Mio、Ikehata Kurumi、Kamijo Shinobu、Ohmori Shigeru、Watanabe Kazuhito
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 366 Issue: 3 Pages: 446-457
- DOI
  10.1124/jpet.118.249557
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08354, KAKENHI-PROJECT-16K08368
[Journal Article] 切迫早産治療薬としてニフェジピンが奏功した一例2016
- Author(s)
  小澤秀介, 小林愛子, 高津亜希子, 神田博仁, 山折　大, 塩沢丹里, 大森　栄
- Journal Title
  
  医療薬学
  
  Volume: 42 Pages: 202-208
- NAID
  130005440106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460167
[Journal Article] Possible Mechanism of Iguratimod–Warfarin Interaction2015
- Author(s)
  Yamaori S, Takami K, Shiozawa A, Sakuyama K, Matsuzawa N, Ohmori S
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 38 Issue: 3 Pages: 441-447
- DOI
  10.1248/bpb.b14-00711
- NAID
  130004872267
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460167
[Journal Article] Cannabidiol induces expression of human cytochrome P450 1A1 that is possibly mediated through aryl hydrocarbon receptor signaling in HepG2 cells2015
- Author(s)
  Yamaori S, Kinugasa Y, Jiang R, Takeda S, Yamamoto I, Watanabe K
- Journal Title
  
  Life Sci.
  
  Volume: 136 Pages: 87-93
- DOI
  10.1016/j.lfs.2015.07.007
- NAID
  120007100188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460167, KAKENHI-PROJECT-25460176
[Journal Article] Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol2014
- Author(s)
  Yamaori S, Okushima Y, Yamamoto I, Watanabe K
- Journal Title
  
  Chem. Biol. Interact.
  
  Volume: 215 Pages: 62-68
- DOI
  10.1016/j.cbi.2014.03.007
- NAID
  120007100189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460167, KAKENHI-PROJECT-25460176
[Journal Article] Differentiation of Monkey Embryonic Stem Cells to Hepatocytes by Feeder-Free Dispersion Culture and Expression Analyses of Cytochrome P450 Enzymes Responsible for Drug Metabolism2013
- Author(s)
  Maruyama J, Matsunaga T, Yamaori S, Sakamoto S, Kamada N, Nakamura K, Kikuchi S, Ohmori S
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 36 Issue: 2 Pages: 292-298
- DOI
  10.1248/bpb.b12-00866
- NAID
  130002480763
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390028
[Journal Article] Significance of CYP2C9 genetic polymorphism in inhibitory effect of Δ9-tetrahydrocannabinol on CYP2C9 activity2013
- Author(s)
  Satoshi Yamaori
- Journal Title
  
  Forensic Toxicol.
  
  Volume: 31 Issue: 1 Pages: 70-75
- DOI
  10.1007/s11419-012-0148-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790159
[Journal Article] Cannabidiol Is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C192013
- Author(s)
  Rongrong Jiang
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 28 Issue: 4 Pages: 332-338
- DOI
  10.2133/dmpk.DMPK-12-RG-129
- NAID
  130004463321
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790159, KAKENHI-PROJECT-25460176
[Journal Article] Comparison in the <i>In Vitro</i> Inhibitory Effects of Major Phytocannabinoids and Polycyclic Aromatic Hydrocarbons Contained in Marijuana Smoke on Cytochrome P450 2C9 Activity2012
- Author(s)
  Satoshi Yamaori
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 27 Issue: 3 Pages: 294-300
- DOI
  10.2133/dmpk.DMPK-11-RG-107
- NAID
  130004463253
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790159
[Journal Article] Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol : role of phenolic hydroxyl groups in the resorcinol moiety.2011
- Author(s)
  Satoshi Yamaori, Juri Ebisawa, Yoshimi Okushima, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Life Sci. Vol.88
  
  Pages: 730-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790135
[Journal Article] Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol : role of phenolic hydroxyl groups in the resorcinol moiety2011
- Author(s)
  S.Yamaori, J.Ebisawa, Y.Okushima, I.Yamamoto, K.Watanabe
- Journal Title
  
  Life Sci.
  
  Volume: 88 Pages: 730-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790135
[Journal Article] Possible involvement of Cyp3a enzymes in the metabolism of tetrahydrocannabinols by mouse brain microsomes2011
- Author(s)
  Kazuhito Watanabe, Mai Fujinami, Satoshi Yamaori, Ikuo Yamamoto
- Journal Title
  
  Foren.Toxicol. 29
  
  Pages: 56-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Cannabidiol, a major phytocannbinoids,as a potent atypical inhibitor forCYP2D6.2011
- Author(s)
  Satoshi Yamaori, Yasuka Okamoto, IkuoYamamoto, Kazuhito Watanabe
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: Vol.39 Issue: 11 Pages: 2049-2056
- DOI
  10.1124/dmd.111.041384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790159
[Journal Article] Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol : role of phenolic hydroxyl groups in the resorcinol moiety2011
- Author(s)
  S.Yamaori
- Journal Title
  
  Life Sci.
  
  Volume: 88 Pages: 730-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol : role of phenolic hydroxyl groups in the resorcinol moiety2011
- Author(s)
  Satoshi Yamaori, Juri Ebisawa, Yoshimi Okushima, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Life Sci. 88
  
  Pages: 730-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes.2010
- Author(s)
  Satoshi Yamaori, Mika Kushihara, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Biochem.Pharmacol. Vol.79
  
  Pages: 1691-1698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790135
[Journal Article] Characterization of major phytocannabinoids, cannabidiol and cannabianol, as isoformselective and potent inhibitors of human CYP1 enzymes2010
- Author(s)
  Satoshi Yamaori, Mika Kushihara, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Biochem.Pharmacol. 79
  
  Pages: 1691-1698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Characterization of major phytocannabinoids, cannabidiol and cannabinol, as isoform-selective and potent inhibitors of human CYP1 enzymes2010
- Author(s)
  S.Yamaori, M.Kushihara, I.Yamamoto, K.Watanabe
- Journal Title
  
  Biochem.Pharmacol.
  
  Volume: 79 Pages: 1691-1698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790135
[Journal Article] Characterization of major phytocannabinoids, cannabidiol and cannabianol, as isoform-selective and potent inhibitors of human CYP1 enzymes2010
- Author(s)
  S.Yamaori
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 79 Pages: 1691-1698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptorindependent signaling2008
- Author(s)
  Shuso Takeda, Satoshi Yamaori, Erina Motoya, Tamihide Matsunaga, Toshiyuki Kimura, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Toxicology 245
  
  Pages: 141-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590127
[Journal Article] Δ9-Tetrahydrocannabinol enhances MCF-7 cell proliferation via cannabinoid receptor-independent signaling2008
- Author(s)
  Takeda, S., Yamaori, S., Motoya, E., Matsunaga, T., Kimura, T., Yamamoto, I., Watanabe, K.
- Journal Title
  
  Toxicology 245
  
  Pages: 141-146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790149
[Journal Article] 大麻文化科学考(その19)2008
- Author(s)
  渡辺和人, 木村敏行, 山折大, 竹田修三, 宇佐見則行, 山本郁男
- Journal Title
  
  紀要(北陸大学) 32
  
  Pages: 1-11
- NAID
  120005469103
- Data Source
  KAKENHI-PROJECT-20790149
[Journal Article] Stimulatory effects of testosterone and progesterone on the NADH- and NADPH-dependent oxidation of 7β-hydroxy-D^8-tetrahydrocannabinol to 7-oxo-Δ^8-tetrahydrocannabinol in monkey liver microsomes2005
- Author(s)
  Tatsuya Funahashi, Yuuki Tanaka, Satoshi Yamaori, Toshiyuki Kimura, Tamihide Matsunaga, Shigeru Ohmori, Takashi Kageyama, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  Drug Metab.Pharmacokinet. 20
  
  Pages: 358-367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] In vitro inhibitory effects of cannabinoids on progesterone 17α-hydroxylase activity in rat testis microsomes2005
- Author(s)
  Tatsuya Funahashi, Hideharu Ikeuchi, Satoshi Yamaori, Toshiyuki Kimura, Ikuo Yamamoto, Kazuhito Watanabe
- Journal Title
  
  J.Health Sci. 51
  
  Pages: 363-375
- NAID
  10016657733
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] In vitro inhibitory effects of cannabinoids on progesterone 17α-hydroxylase activity in rat testis microsomes2005
- Author(s)
  T.Funahashi, H.Ikeuchi, S.Yamaori, T.Kimura, I.Yamamoto, K.Watanabe
- Journal Title
  
  J.Health Sci. 51・3
  
  Pages: 369-375
- NAID
  10016657733
- Data Source
  KAKENHI-PROJECT-16790092
[Journal Article] Stereospecific and regioselective hydrolysis of cannabinoid esters by ES46.5K, an esterase from mouse hepatic microsomes, and its differences from carboxylesterases of rabbit and porcine liver2005
- Author(s)
  Kazuhito Watanabe, Tamihide Matsunaga, Toshiyuki Kimura, Tatsuya Funahashi, Satoshi Yamaori, Yukihiro Shoyama, Ikuo Yamamoto
- Journal Title
  
  Biol.Pharm.Bull. 28
  
  Pages: 1743-1747
- NAID
  110003666503
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590096
[Journal Article] Stimulatory effects of testosterone and progesterone on the NADH- and NADPH-dependent oxidation of 7β-hydroxy-Δ^8-tetrahydrocannabinol to 7-oxo-Δ^8-tetrahydrocannabinol in monkey liver microsomes2005
- Author(s)
  T.Funahashi, Y.Tanaka, S.Yamaori, T.Kimura, T.Matsunaga, S.Ohmori, T.Kageyama, I.Yamamoto, K.Watanabe
- Journal Title
  
  Drug Metab.Pharmacokinet. 20・5
  
  Pages: 358-367
- Data Source
  KAKENHI-PROJECT-16790092
[Journal Article] Stereospecific and regioselective hydrolysis of cannabinoid esters by ES46.5K, an esterase from mouse hepatic microsomes, and its differences from carboxylesterases of rabbit and porcine liver2005
- Author(s)
  K.Watanabe, T.Matsunaga, T.Kimura, T.Funahashi, S.Yamaori, Y.Shoyama, I.Yamamoto
- Journal Title
  
  Biol.Pharm.Bull. 20・9
  
  Pages: 1743-1747
- NAID
  110003666503
- Data Source
  KAKENHI-PROJECT-16790092
[Journal Article] In vitro inhibitory effects of cannabinoids on progesterone 17α-hydroxylase activity in rat testis microsomes
- Author(s)
  T.Funahashi, H.Ikeuchi, S.Yamaori, T.Kimura, I.Yamamoto, K.Watanabe
- Journal Title
  
  J.Health Sci. (印刷中)
- NAID
  10016657733
- Data Source
  KAKENHI-PROJECT-16790092
[Presentation] ヒト神経細胞株におけるシトクロムP450の発現プロファイルと薬物応答性2021
- Author(s)
  山折　大
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07063
[Presentation] ヒトアストロサイト由来MOG-G-CCM細胞における抗てんかん薬と多環芳香族炭化水素によるCYP1遺伝子の発現誘導能の解析2021
- Author(s)
  小澤秀介，山折　大，相川香織，上条しのぶ，大森　栄
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07063
[Presentation] 薬物および内因性物質の代謝的相互作用に着目したP450阻害剤の機構解析に関する研究2020
- Author(s)
  山折　大
- Organizer
  日本薬物動態学会第35回年会
- Data Source
  KAKENHI-PROJECT-19K07063
[Presentation] ヒトCYP2J2活性に対する降圧薬の阻害効果2019
- Author(s)
  山折　大，池村憲明，小林千夏，上条しのぶ，村山典恵，山崎浩史，大森　栄
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-19K07063
[Presentation] Characterization of antihypertensive drugs as potent inhibitors of CYP2J22018
- Author(s)
  Yamaori S, Ikemura N, Kobayashi C, Kamijo S, Ohmori S
- Organizer
  22nd North American International Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08368
[Presentation] ヒト胎児肝細胞における糖質コルチコイドによる硫酸転移酵素SULT1E1の発現誘導2017
- Author(s)
  山折　大、相川香織、上条しのぶ、松永民秀、大森　栄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-16K08368
[Presentation] エパルレスタットによるCYP4A11の選択的阻害作用2015
- Author(s)
  山折　大, 荒木規行, 池畑くるみ, 大森　栄, 渡辺和人
- Organizer
  日本薬物動態学会第30回年会
- Place of Presentation
  タワーホール船堀（東京）
- Year and Date
  2015-11-12
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] Metabolism of major phytocannabinoids by human placenta microsomes and CYP192015
- Author(s)
  Watanabe K, Inoue K, Murai M, Usami N, Yamaori S, Yamamoto I
- Organizer
  The 53rd Annual Meeting of the International Association of Forensic Toxicologists
- Place of Presentation
  Florence (Italy)
- Year and Date
  2015-08-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] Inducibility of CYP enzymes by cannabidiol2015
- Author(s)
  Watanabe K, Yamaori S, Jiang R, Kinugasa Y, Okushima Y, Yamamoto I
- Organizer
  25th Annual Symposium of the International Cannabinoid Research Society
- Place of Presentation
  Wolfville (Canada)
- Year and Date
  2015-06-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] Potency and mechanism of CYP2J2 inhibition by major phytocannabinoids2015
- Author(s)
  Yamaori S, Nagata Y, Ohmori S, Yamamoto I, Watanabe K
- Organizer
  20th North American ISSX Meeting
- Place of Presentation
  Orlando (USA)
- Year and Date
  2015-10-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] ダナゾールのヒトCYP3A活性に対する阻害作用2014
- Author(s)
  山折　大，津田有加，大森　栄，渡辺和人
- Organizer
  医療薬学フォーラム2014／第22回クリニカルファーマシーシンポジウム
- Place of Presentation
  ビッグサイトTFTホール
- Year and Date
  2014-06-29
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] Evaluation of Luciferin-4A O-demethylase activity as a CYP4A11 marker in human liver and kidney microsomes2014
- Author(s)
  Yamaori S, Shionoiri M, Ohmori S, Watanabe K
- Organizer
  19th North American ISSX Meeting and 29th JSSX Annual Meeting
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-10-20
- Data Source
  KAKENHI-PROJECT-25460167
[Presentation] Inhibitory effects of major phytocannabinoids in marijuana on human drug-metabolizing cytochrome P450s and their possible mechanisms2012
- Author(s)
  Satoshi Yamaori
- Organizer
  The International Association of Forensic Toxicologists
- Place of Presentation
  アクトシティ浜松
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻主成分カンナビジオールによるCYP2C19 の阻害とその機構2012
- Author(s)
  蒋融融、山折大、山本郁男、渡辺和人
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] Inhibitory effects of major phytocannabinoids in marijuana on human drug-metabolizing cytochrome P450s and their possible mechanisms2012
- Author(s)
  Satoshi Yamaori
- Organizer
  The International Association of Forensic Toxicologists
- Place of Presentation
  アクトシティ浜松(静岡県)
- Year and Date
  2012-06-08
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻主成分カンナビジオールによるCYP2C19の阻害とその機構2012
- Author(s)
  蒋融融, 山折大, 山本郁男, 渡辺和人
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学（北海道）
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] Small molecule compounds enhance differentiation to hepatocytes from human induced pluripotent stem cells(低分子化合物はヒト人工多能性幹細胞から肝細胞への分化を促進する).2012
- Author(s)
  近藤祐樹,岩尾岳洋,吉橋幸美,三森佳代,杉山留理,佐々木崇光,永田清,黒瀬光一,丹羽卓朗,山折大,大森栄,中村克徳,松永民秀
- Organizer
  日本薬物動態学会第27回年会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-22390028
[Presentation] 大麻煙含有成分の CYP2C9 活性に対する影響2012
- Author(s)
  山折大、小枝恭子、山本郁男、渡辺和人
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学(北海道)
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻主成分カンナビジオールは強力かつ非典型的なCYP2D6阻害剤である2012
- Author(s)
  山折　大
- Organizer
  日本薬物動態学会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻煙含有成分のCYP2C9活性に対する影響2012
- Author(s)
  山折大, 小枝恭子, 山本郁男, 渡辺和人
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学（北海道）
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻主成分カンナビジオールは強力かつ非典型的な CYP2D6 阻害剤である2012
- Author(s)
  山折大、岡本泰佳、大森栄、山本郁男、渡辺和人
- Organizer
  日本薬物動態学会
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻主成分カンナビノイドによるニコチン代謝酵素CYP2A6およびCYP2B6の阻害機構2011
- Author(s)
  山折大, 前田千佳子, 山本郁男, 渡辺和人
- Organizer
  日本法中毒学会
- Place of Presentation
  長崎大学中部講堂（長崎県）
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] Metabolism of cannabidiol by cytochrome P450s in human liver microsomes2011
- Author(s)
  R. Jiang, S. Yamaori, S. Takeda, I. Yamamoto, K. Watanabe
- Organizer
  International Cannabinoid Research Society
- Place of Presentation
  Pheasant Run (IL, USA)
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] Metabolism of cannabidiol by cytochrome P450s in human liver microsomes、International Cannabinoid Research Society2011
- Author(s)
  Rongrong Jiang、 Satoshi Yamaori、 Shuso Takeda 、 Ikuo Yamamoto 、 Kazuhito Watanabe
- Organizer
  International Cannabinoid Research Society
- Place of Presentation
  Pheasant Run (IL、USA)
- Year and Date
  2011-07-07
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻成分の代謝的相互作用とその個人差2011
- Author(s)
  山折大
- Organizer
  日本法中毒学会
- Place of Presentation
  長崎大学中部講堂（長崎県）
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] Inhibitory mechanism of major phytocannabinoids on cytochrome P450 2D6 activity2011
- Author(s)
  Satoshi Yamaori、Yasuka Okamoto、Ikuo Yamamoto 、 Kazuhito Watanabe
- Organizer
  International Cannabinoid Research Society
- Place of Presentation
  Pheasant Run (IL、USA)
- Year and Date
  2011-07-07
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] Inhibitory mechanism of major phytocannabinoids on cytochrome P450 2D6 activity2011
- Author(s)
  S. Yamaori, Y. Okamoto, I. Yamamoto, K. Watanabe
- Organizer
  International Cannabinoid Research Society
- Place of Presentation
  Pheasant Run (IL, USA)
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻主成分カンナビノイドのヒト肝薬物代謝酵素シトクロムP450に対する阻害作用2011
- Author(s)
  山折大
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡市、ツインメッセ静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590127
[Presentation] 大麻主成分カンナビノイドによるニコチン代謝酵素 CYP2A6 および CYP2B6の阻害機構2011
- Author(s)
  山折大、前田千佳子、山本郁男、渡辺和人
- Organizer
  日本法中毒学会
- Place of Presentation
  長崎大学中部講堂(長崎県)
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻成分の代謝的相互作用とその個人差2011
- Author(s)
  山折大
- Organizer
  日本法中毒学会
- Place of Presentation
  長崎大学中部講堂(長崎県)
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-23790159
[Presentation] 大麻非幻覚成分カンナビジオールによるヒトCYP3Aの可逆的阻害2010
- Author(s)
  山折大
- Organizer
  日本薬物動態学会第25回年会
- Place of Presentation
  大宮市、大宮ソニックシティ
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20590127
[Presentation] 大麻非幻覚成分カンナビジオールによるヒトCYP1A1発現誘導2009
- Author(s)
  山折大
- Organizer
  フォーラム2009 衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-21790135
[Presentation] 大麻非幻覚成分カンナビジオールによるヒトCYPIA1発現誘導2009
- Author(s)
  山折大
- Organizer
  フォーラム2009衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-21790135
[Presentation] Selectivity of major cannabinoids toward inhibition of human CYP3A isoforms2008
- Author(s)
  S. Yamaori
- Organizer
  MDO2008
- Place of Presentation
  Saratoga Springs, U.S.A.
- Data Source
  KAKENHI-PROJECT-20590127
[Presentation] △^9-テトラヒドロカンナビノール, カンナビジオール及びカンナビノールによるヒトCYP1酵素の代謝依存的阻害の解析2008
- Author(s)
  山折大
- Organizer
  日本法中毒学会第27年会
- Place of Presentation
  東京都、昭和大学上条講堂
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-20590127
[Presentation] Selectivity of major cannabinoids toward inhibition of human CYP3A isoforms2008
- Author(s)
  Satoshi Yamaori
- Organizer
  MDO2008
- Place of Presentation
  サラトガスプリングス U.S.A.
- Data Source
  KAKENHI-PROJECT-20590127
[Presentation] Δ9-テトラヒドロカンナビノール、カンナビジオールおよびカンナビノールによるヒトCYP1 酵素の代謝依存的阻害の解析2008
- Author(s)
  山折大
- Organizer
  日本法中毒学会第27年会
- Place of Presentation
  東京都、昭和大学上条講堂
- Year and Date
  2008-06-13
- Data Source
  KAKENHI-PROJECT-20590127

1. WATANABE Kazuhito (30113038)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
2. YAMAMOTO Ikuo (50069746)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. OHMORI Shigeru (70169069)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
4. TATEDA Shuso (00460379)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. FUNAHASHI Tatsuya (60343646)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. MATSUNAGA Tamihide (40209581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. NAKAMURA Katsunori (20361363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KIMURA Toshiyuki (20234370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 吉成浩一 (60343399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yamaori Satoshi 山折 大

YAMAORI Satoshi 山折 大

Research Projects

Research Products

Co-Researchers

Exploration of drugs to potently and selectively inhibit human CYP2J2 activity and evaluation of their antitumor effect on human tumor cell linesPrincipal Investigator

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Elucidation of mechanisms underlying different glucocorticoid responses of drug-metabolizing enzymes, SULT1E1 and CYP3A7, in human fetal liver cells

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Estimation of fetotoxicity of chemical compounds with human fetal liver cells and molecular basis of their toxicitiesPrincipal Investigator

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Mechanisms underlying inhibition of human cytochrome P450 enzymesby major phytocannabinoidsPrincipal Investigator

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Differentiation ofhuman iPS cells into hepatocytes and bile duct epithelial cells and application to drug development study

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Mechanism underlying induction of human CYP1A1 gene by major phytocannabinoidsPrincipal Investigator

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Molecular mechanism for interaction of major cannabinoids with enzyme system

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Preventive pharmaceutical research for the appropriate use of the principal marijuana constituent in clinical contexts

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大麻成分カンナビノイド活性代謝物の細胞毒性発現機構の解明Principal Investigator

Principal Investigator

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Involvement of endogenous cannabinoids in the pharmacological effects of cannabinoids

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Hypnotic and antinociceptive effects of N3-substituted oxopyrimidines and their mechanism

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[Journal Article] Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells2020

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[Journal Article] Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: potent inhibition by azelnidipine and manidipine2019

Author(s)

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DOI

Yamaori Satoshi 山折大

YAMAORI Satoshi 山折大