OGIHARA Takehide 荻原健英

Researcher Number	40361068
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008: 東北大学, 大学院, 准教授 2007: 東北大, 医学(系)研究科(研究院), 助教授 2007: Tohoku University, School of Medicine, Associate Professor 2005 – 2006: 東北大学, 大学院医学系研究科, 助教授 2004 – 2005: 東北大学, 大学院・医学系研究科, 助教授
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Metabolomics / Pathological medical chemistry
Keywords	Principal Investigator 糖尿病 / 骨髄移植 / 再生医学 / 内科 / NF-κB / 血管内皮細胞 / 肝臓 / 動脈硬化 / 酸化ストレス / 炎症 / インスリン抵抗性 … More Except Principal Investigator … More 糖尿病 / obesity / metabolic syndrome / diabetes / 肥満 / メタボリックシンドローム / Signal Transduction / Pancreatic Islet / Diabetes Mellitus / 分子生物学 / カルシウム / マイクロアレイ / アポトーシス / 小胞体ストレス / グルカゴン分泌 / インスリン分泌 / 膵ランゲルハンス島 / シグナル伝達 / 膵島 / 酸化LDL / 脂質代謝 / 動脈硬化 Less

The impact of oxidized LDL removal on atherosclerosis
- Principal Investigator
  
  ISHIGAKIB Yasushi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
骨髄移植を利用した膵β細胞再生治療の新展開Principal Investigator
- Principal Investigator
  
  荻原健英
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
Unraveling liver-derived signals against obesity and diabetes
- Principal Investigator
  
  KATAGIRI Hideki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University
Molecular Mechanisms for Pancreatic Islet Disfunction in Development of Diabetes Mellitus-a study using WFS1 knockout mice
- Principal Investigator
  
  ISHIHARA Hisamitsu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tohoku University
炎症・酸化ストレスに伴うインスリン抵抗性の分子機構の解明とその治療法の開発Principal Investigator
- Principal Investigator
  
  荻原健英
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Tohoku University

All 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] 薬剤師・薬学生のための臨床医学「代謝疾患へのアプローチ」2005
- Author(s)
  荻原健英(分担執筆)
- Total Pages
  1536
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atheroscleros is in subjectswith type 2 diabetes2008
- Author(s)
  Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H., Ohkubo T, Hasegawa H, Kanai H, Oka Y
- Journal Title
  
  Atherosclerosis 196
  
  Pages: 188-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Impact of Plasma Oxidized LDL Removal on Atherosclerosis2008
- Author(s)
  Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y
- Journal Title
  
  Circulation 118(1)
  
  Pages: 75-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591031
[Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes.2008
- Author(s)
  Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H., Ohkubo T, Hasegawa H, Kanai H, Oka Y.
- Journal Title
  
  Atherosclerosis 196
  
  Pages: 391-397
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes2008
- Author(s)
  Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H, Ohkubo T, Hasegawa H, Kanai H, Oka Y.
- Journal Title
  
  Atherosclerosis 196
  
  Pages: 391-397
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.2007
- Author(s)
  Cao J., Katagiri H., Ishigaki Y., Yamada T., Ogihara T., Imai J., Uno K., Hasegawa Y., Kanzaki M., Yamamoto TT., Ishibashi S., Oka Y.
- Journal Title
  
  Diabetes 56
  
  Pages: 24-33
- NAID
  10027299912
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Bone Marrow (BM) Transplantation Promotes Beta Cell Regeneration after Acute Injury throgh BM Cell Mobilization.2007
- Author(s)
  Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H.
- Journal Title
  
  Endocrinology 148
  
  Pages: 2006-2015
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Caroboxyl-terminal modulator protein(CTMP)induces AKT activation, thereby enhancing anti-apoptotic, glycogen synthetic and glucose uptake pathways2007
- Author(s)
  Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T
- Journal Title
  
  Am J Physiol Cell Physiol 293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Caroboxyl-terminal modulator protein (CTMP) induces AKT activation, thereby enhancing anti-apoptotic, glycogen synthetic and glucose uptake pathways2007
- Author(s)
  Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T.
- Journal Title
  
  Am J Physiol Cell Physiol 293
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Caroboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.2007
- Author(s)
  Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T.
- Journal Title
  
  Am J Physiol Cell Physiol 293
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Bone Marrow(BM)Transplantation Promotes Beta Cell Regeneration after Acute Injury through BM Cell Mobilization2007
- Author(s)
  Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H
- Journal Title
  
  Endocrinology 148
  
  Pages: 2006-2015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance2007
- Author(s)
  Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imao J, Uno K. Hasegaw Y, Kanzaki M, Yamamoto TT, Ishibashi S, Oka Y.
- Journal Title
  
  Diabetes 56
  
  Pages: 24-33
- NAID
  10027299912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Bone Marrow (BM) Transplantation Promotes Beta Cell Regeneration after Acute Injury through BM Cell Mobilization2007
- Author(s)
  Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H.
- Journal Title
  
  Endocrinology 148
  
  Pages: 2006-2015
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.2007
- Author(s)
  Gao J., Katagiri H., Ishigaki Y., Yamada T., Ogihara T., Imai J., Uno K., Hasegawa Y., Kanzaki M., Yamamoto TT., Ishibashi S., Oka Y
- Journal Title
  
  Diabetes 56
  
  Pages: 24-33
- NAID
  10027299912
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.2006
- Author(s)
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
- Journal Title
  
  Science 312
  
  Pages: 1656-1659
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Cold Exposure Suppresses Serum Adiponectin Levels through Sympathetic Nerve Activation in Mice.2006
- Author(s)
  imai, J, Katagiri, H., Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K, Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y.
- Journal Title
  
  Obesity 14
  
  Pages: 1132-1141
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Activation of sympathetic nervous system suppresses serum adiponectin levels in mice.2006
- Author(s)
  Imai, J, Katagiri, H., Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K, Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y
- Journal Title
  
  Obesity 14
  
  Pages: 1132-1141
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms Neuronal involvement in food-intake regulation.2006
- Author(s)
  Yamada T, Katagiri H, Ishigaki Y, Ogihara T, et al.
- Journal Title
  
  Cell Metab 3
  
  Pages: 223-229
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity2006
- Author(s)
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y.
- Journal Title
  
  Science 312
  
  Pages: 1656-1659
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.2006
- Author(s)
  Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y.
- Journal Title
  
  Science 312
  
  Pages: 1656-1659
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Cold Exposure Suppresses Serum Adiponectin Levels through Sympathetic Nerve Activation in Mice2006
- Author(s)
  Imai, J, Katagiri, H, Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y.
- Journal Title
  
  Obesity 14
  
  Pages: 1132-1141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Journal Article] Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.2005
- Author(s)
  Ishigaki Y, Katagiri H, Yamada T, Ogihara T, et al.
- Journal Title
  
  Diabetes 54
  
  Pages: 322-332
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.2005
- Author(s)
  Shojima N, Ogihara T, et al.
- Journal Title
  
  Diabetologia 48
  
  Pages: 984-992
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] Glycogen debranching enzyme association with beta-subunit regulate s AMP-activated protein kinase activity.2005
- Author(s)
  Sakoda H, Fujishiro M, Fujio J, Shiojima N, Ogihara T, et al.
- Journal Title
  
  Am J Physiol Endocrinol Metab 289
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] A novel protein kinase B(PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.2005
- Author(s)
  Anai M, Shojima N, Katagiri H, Ogihara T, et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 18525-18535
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.2005
- Author(s)
  Kushiyama A, Shojima N, Ogihara T, et al.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 42016-42025
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular_distribution of phosphatidylinositol 3-kinase.2004
- Author(s)
  Ogihara T, et al.
- Journal Title
  
  Diabetologia 47巻
  
  Pages: 794-805
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] インスリン抵抗性とNF-κB経路2004
- Author(s)
  荻原健英
- Journal Title
  
  内分泌・糖尿病科 18巻
  
  Pages: 364-368
- Data Source
  KAKENHI-PROJECT-16790503
[Journal Article] アンジオテンシンIIおよびNF-κB経路を介したインスリン抵抗性の調節機構2004
- Author(s)
  荻原健英
- Journal Title
  
  血管 27巻
  
  Pages: 89-95
- NAID
  10013505673
- Data Source
  KAKENHI-PROJECT-16790503
[Presentation] Bone Marrow Transplantation Promotes β Cell Regeneration after Acute Injury through Bone Marrow Cell Mobilization2006
- Author(s)
  Hasegawa Y., Katagiri H., Ogihara T., Saito T., Oka Y
- Organizer
  Tohoku University 21st century COE program The 3rd International Symposium
- Place of Presentation
  Sendai, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Presentation] Generation of Insulin-Producing Cells in the Liver and Regeneration of Pancreatic Beta Cells by Mobilization of Bone Marrow Cells.2006
- Author(s)
  Katagiri H., Ogihara T., Imai J., Hasegawa Y., Oka Y
- Organizer
  49^<th> Annual Meeting of the Japan Diabetes Society
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2006-05-26
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Presentation] Bone Marrow Transplantation Promotes 6 Cell Regeneration after Acute Injury through Bone Marrow Cell Mobilization2006
- Author(s)
  Hasegawa Y., Katagiri H., Ogihara T., Saito T., Oka Y
- Organizer
  Tbhoku University 21st century COE program The 3rd International Symposium
- Place of Presentation
  Sendai, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Presentation] Bone Marrow-derived Cell Recruitment Is Involved in Regeneration after Pancreatic Beta Cell Injury2006
- Author(s)
  Ogihara T., Katagiri H., Hasegawa Y. Oka Y
- Organizer
  20th IUBMB International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390267
[Presentation] 肝におけるインスリン産生細胞の創生と骨髄細胞動員による膵β細胞の再生2006
- Author(s)
  片桐秀樹、荻原健英、今井淳太、長谷川豊、岡芳知
- Organizer
  第49回日本糖尿病学会年次学術総会
- Place of Presentation
  東京
- Year and Date
  2006-05-26
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390267

1. YAMADA Etsuya (90400374)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. ISHIGAKIB Yasushi (50375002)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
3. ISHIHARA Hisamitsu (60361086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TAMURA Akira (00375023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KATAGIRI Hideki (00344664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results

OGIHARA Takehide 荻原 健英

Research Projects

Research Products

Co-Researchers

The impact of oxidized LDL removal on atherosclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

骨髄移植を利用した膵β細胞再生治療の新展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Unraveling liver-derived signals against obesity and diabetes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular Mechanisms for Pancreatic Islet Disfunction in Development of Diabetes Mellitus-a study using WFS1 knockout mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

炎症・酸化ストレスに伴うインスリン抵抗性の分子機構の解明とその治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 薬剤師・薬学生のための臨床医学「代謝疾患へのアプローチ」2005

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atheroscleros is in subjectswith type 2 diabetes2008

Author(s)

Journal Title

Data Source

[Journal Article] Impact of Plasma Oxidized LDL Removal on Atherosclerosis2008

Author(s)

Journal Title

Data Source

[Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes.2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes2008

Author(s)

Journal Title

Description

Data Source

[Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] Bone Marrow (BM) Transplantation Promotes Beta Cell Regeneration after Acute Injury throgh BM Cell Mobilization.2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Caroboxyl-terminal modulator protein(CTMP)induces AKT activation, thereby enhancing anti-apoptotic, glycogen synthetic and glucose uptake pathways2007

Author(s)

Journal Title

Data Source

[Journal Article] Caroboxyl-terminal modulator protein (CTMP) induces AKT activation, thereby enhancing anti-apoptotic, glycogen synthetic and glucose uptake pathways2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Caroboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.2007

Author(s)

Journal Title

OGIHARA Takehide 荻原健英