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OGIHARA Takehide  荻原 健英

ORCIDConnect your ORCID iD *help
Researcher Number 40361068
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2008: 東北大学, 大学院, 准教授
2007: 東北大, 医学(系)研究科(研究院), 助教授
2007: Tohoku University, School of Medicine, Associate Professor
2005 – 2006: 東北大学, 大学院医学系研究科, 助教授
2004 – 2005: 東北大学, 大学院・医学系研究科, 助教授
Review Section/Research Field
Principal Investigator
Metabolomics
Except Principal Investigator
Metabolomics / Pathological medical chemistry
Keywords
Principal Investigator
糖尿病 / 骨髄移植 / 再生医学 / 内科 / NF-κB / 血管内皮細胞 / 肝臓 / 動脈硬化 / 酸化ストレス / 炎症 / インスリン抵抗性 … More
Except Principal Investigator
… More 糖尿病 / obesity / metabolic syndrome / diabetes / 肥満 / メタボリックシンドローム / Signal Transduction / Pancreatic Islet / Diabetes Mellitus / 分子生物学 / カルシウム / マイクロアレイ / アポトーシス / 小胞体ストレス / グルカゴン分泌 / インスリン分泌 / 膵ランゲルハンス島 / シグナル伝達 / 膵島 / 酸化LDL / 脂質代謝 / 動脈硬化 Less
  • Research Projects

    (5 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (5 People)
  •  The impact of oxidized LDL removal on atherosclerosis

    • Principal Investigator
      ISHIGAKIB Yasushi
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  骨髄移植を利用した膵β細胞再生治療の新展開Principal Investigator

    • Principal Investigator
      荻原 健英
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  Unraveling liver-derived signals against obesity and diabetes

    • Principal Investigator
      KATAGIRI Hideki
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University
  •  Molecular Mechanisms for Pancreatic Islet Disfunction in Development of Diabetes Mellitus-a study using WFS1 knockout mice

    • Principal Investigator
      ISHIHARA Hisamitsu
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University
  •  炎症・酸化ストレスに伴うインスリン抵抗性の分子機構の解明とその治療法の開発Principal Investigator

    • Principal Investigator
      荻原 健英
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Tohoku University

All 2008 2007 2006 2005 2004

All Journal Article Presentation Book

  • [Book] 薬剤師・薬学生のための臨床医学「代謝疾患へのアプローチ」2005

    • Author(s)
      荻原健英(分担執筆)
    • Total Pages
      1536
    • Publisher
      文光堂
    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atheroscleros is in subjectswith type 2 diabetes2008

    • Author(s)
      Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H., Ohkubo T, Hasegawa H, Kanai H, Oka Y
    • Journal Title

      Atherosclerosis 196

      Pages: 188-198

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Impact of Plasma Oxidized LDL Removal on Atherosclerosis2008

    • Author(s)
      Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K, Hasegawa Y, Kaneko K, Ogihara T, Ishihara H, Sato Y, Takikawa K, Nishimichi N, Matsuda H, Sawamura T, Oka Y
    • Journal Title

      Circulation 118(1)

      Pages: 75-83

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591031
  • [Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes.2008

    • Author(s)
      Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H., Ohkubo T, Hasegawa H, Kanai H, Oka Y.
    • Journal Title

      Atherosclerosis 196

      Pages: 391-397

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] A novel method for evaluating human carotid artery elasticity: possible detection of early stage atherosclerosis in subjects with type 2 diabetes2008

    • Author(s)
      Okimoto H, Ishigaki Y, Koiwa Y, Hinikio Y, Ogihara T, Suzuki S, Katagiri H, Ohkubo T, Hasegawa H, Kanai H, Oka Y.
    • Journal Title

      Atherosclerosis 196

      Pages: 391-397

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.2007

    • Author(s)
      Cao J., Katagiri H., Ishigaki Y., Yamada T., Ogihara T., Imai J., Uno K., Hasegawa Y., Kanzaki M., Yamamoto TT., Ishibashi S., Oka Y.
    • Journal Title

      Diabetes 56

      Pages: 24-33

    • NAID

      10027299912

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Bone Marrow (BM) Transplantation Promotes Beta Cell Regeneration after Acute Injury throgh BM Cell Mobilization.2007

    • Author(s)
      Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H.
    • Journal Title

      Endocrinology 148

      Pages: 2006-2015

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Caroboxyl-terminal modulator protein(CTMP)induces AKT activation, thereby enhancing anti-apoptotic, glycogen synthetic and glucose uptake pathways2007

    • Author(s)
      Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T
    • Journal Title

      Am J Physiol Cell Physiol 293

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Caroboxyl-terminal modulator protein (CTMP) induces AKT activation, thereby enhancing anti-apoptotic, glycogen synthetic and glucose uptake pathways2007

    • Author(s)
      Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T.
    • Journal Title

      Am J Physiol Cell Physiol 293

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Caroboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways.2007

    • Author(s)
      Ono H, Sakoda H, Fujishiro M, Anai M, Kushiyama A, Fukushima Y, Katagiri H, Ogihara T, Oka Y, Kamata H, Horike N, Uchijima Y, Kurihara H, Asano T.
    • Journal Title

      Am J Physiol Cell Physiol 293

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Bone Marrow(BM)Transplantation Promotes Beta Cell Regeneration after Acute Injury through BM Cell Mobilization2007

    • Author(s)
      Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H
    • Journal Title

      Endocrinology 148

      Pages: 2006-2015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance2007

    • Author(s)
      Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imao J, Uno K. Hasegaw Y, Kanzaki M, Yamamoto TT, Ishibashi S, Oka Y.
    • Journal Title

      Diabetes 56

      Pages: 24-33

    • NAID

      10027299912

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Bone Marrow (BM) Transplantation Promotes Beta Cell Regeneration after Acute Injury through BM Cell Mobilization2007

    • Author(s)
      Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K, Gao J, Kaneko K, Ishihara H, Sasano H, Nakauchi H, Oka Y, Katagiri H.
    • Journal Title

      Endocrinology 148

      Pages: 2006-2015

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Involvement of apolipoprotein E in excess fat accumulation and insulin resistance.2007

    • Author(s)
      Gao J., Katagiri H., Ishigaki Y., Yamada T., Ogihara T., Imai J., Uno K., Hasegawa Y., Kanzaki M., Yamamoto TT., Ishibashi S., Oka Y
    • Journal Title

      Diabetes 56

      Pages: 24-33

    • NAID

      10027299912

    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.2006

    • Author(s)
      Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y
    • Journal Title

      Science 312

      Pages: 1656-1659

    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Cold Exposure Suppresses Serum Adiponectin Levels through Sympathetic Nerve Activation in Mice.2006

    • Author(s)
      imai, J, Katagiri, H., Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K, Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y.
    • Journal Title

      Obesity 14

      Pages: 1132-1141

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Activation of sympathetic nervous system suppresses serum adiponectin levels in mice.2006

    • Author(s)
      Imai, J, Katagiri, H., Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K, Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y
    • Journal Title

      Obesity 14

      Pages: 1132-1141

    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms Neuronal involvement in food-intake regulation.2006

    • Author(s)
      Yamada T, Katagiri H, Ishigaki Y, Ogihara T, et al.
    • Journal Title

      Cell Metab 3

      Pages: 223-229

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity2006

    • Author(s)
      Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y.
    • Journal Title

      Science 312

      Pages: 1656-1659

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.2006

    • Author(s)
      Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y.
    • Journal Title

      Science 312

      Pages: 1656-1659

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Cold Exposure Suppresses Serum Adiponectin Levels through Sympathetic Nerve Activation in Mice2006

    • Author(s)
      Imai, J, Katagiri, H, Yamada, T, Ishigaki, Y, Ogihara, T, Uno, K Hasegawa, Y, Gao, J, Ishihara, H, Oka, Y.
    • Journal Title

      Obesity 14

      Pages: 1132-1141

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Journal Article] Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.2005

    • Author(s)
      Ishigaki Y, Katagiri H, Yamada T, Ogihara T, et al.
    • Journal Title

      Diabetes 54

      Pages: 322-332

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] Serum concentrations of resistin-like molecules beta and gamma are elevated in high-fat-fed and obese db/db mice, with increased production in the intestinal tract and bone marrow.2005

    • Author(s)
      Shojima N, Ogihara T, et al.
    • Journal Title

      Diabetologia 48

      Pages: 984-992

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] Glycogen debranching enzyme association with beta-subunit regulate s AMP-activated protein kinase activity.2005

    • Author(s)
      Sakoda H, Fujishiro M, Fujio J, Shiojima N, Ogihara T, et al.
    • Journal Title

      Am J Physiol Endocrinol Metab 289

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] A novel protein kinase B(PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis.2005

    • Author(s)
      Anai M, Shojima N, Katagiri H, Ogihara T, et al.
    • Journal Title

      J Biol Chem 280

      Pages: 18525-18535

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] Resistin-like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes, and induces diabetes, hyperlipidemia, and fatty liver in transgenic mice on a high fat diet.2005

    • Author(s)
      Kushiyama A, Shojima N, Ogihara T, et al.
    • Journal Title

      J Biol Chem 280

      Pages: 42016-42025

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular_distribution of phosphatidylinositol 3-kinase.2004

    • Author(s)
      Ogihara T, et al.
    • Journal Title

      Diabetologia 47巻

      Pages: 794-805

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] インスリン抵抗性とNF-κB経路2004

    • Author(s)
      荻原 健英
    • Journal Title

      内分泌・糖尿病科 18巻

      Pages: 364-368

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Journal Article] アンジオテンシンIIおよびNF-κB経路を介したインスリン抵抗性の調節機構2004

    • Author(s)
      荻原 健英
    • Journal Title

      血管 27巻

      Pages: 89-95

    • NAID

      10013505673

    • Data Source
      KAKENHI-PROJECT-16790503
  • [Presentation] Bone Marrow Transplantation Promotes β Cell Regeneration after Acute Injury through Bone Marrow Cell Mobilization2006

    • Author(s)
      Hasegawa Y., Katagiri H., Ogihara T., Saito T., Oka Y
    • Organizer
      Tohoku University 21st century COE program The 3rd International Symposium
    • Place of Presentation
      Sendai, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Presentation] Generation of Insulin-Producing Cells in the Liver and Regeneration of Pancreatic Beta Cells by Mobilization of Bone Marrow Cells.2006

    • Author(s)
      Katagiri H., Ogihara T., Imai J., Hasegawa Y., Oka Y
    • Organizer
      49^<th> Annual Meeting of the Japan Diabetes Society
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2006-05-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Presentation] Bone Marrow Transplantation Promotes 6 Cell Regeneration after Acute Injury through Bone Marrow Cell Mobilization2006

    • Author(s)
      Hasegawa Y., Katagiri H., Ogihara T., Saito T., Oka Y
    • Organizer
      Tbhoku University 21st century COE program The 3rd International Symposium
    • Place of Presentation
      Sendai, Japan
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Presentation] Bone Marrow-derived Cell Recruitment Is Involved in Regeneration after Pancreatic Beta Cell Injury2006

    • Author(s)
      Ogihara T., Katagiri H., Hasegawa Y. Oka Y
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Kyoto, Japan
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • [Presentation] 肝におけるインスリン産生細胞の創生と骨髄細胞動員による膵β細胞の再生2006

    • Author(s)
      片桐秀樹、荻原健英、今井淳太、長谷川豊、岡芳知
    • Organizer
      第49回日本糖尿病学会年次学術総会
    • Place of Presentation
      東京
    • Year and Date
      2006-05-26
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390267
  • 1.  YAMADA Etsuya (90400374)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 13 results
  • 2.  ISHIGAKIB Yasushi (50375002)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 16 results
  • 3.  ISHIHARA Hisamitsu (60361086)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  TAMURA Akira (00375023)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KATAGIRI Hideki (00344664)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 23 results

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