Kurosu Tetsuya 黒須哲也

… Alternative Names

KUROSU Tetsuya 黒須哲也

黒須哲也クロステツヤ

Less

Researcher Number	40361696
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2016: 東京医科歯科大学, 医学部, 非常勤講師 2014: 東京医科歯科大学, 医学部附属病院, 非常勤講師 2010 – 2012: 東京医科歯科大学, 医学部附属病院, 助教 2005: 東京医科歯科大学, 医学部附属病院, 助手 2004: 東京医科歯科大学, 医学部付属病院, 助手
Review Section/Research Field	Principal Investigator Hematology
Keywords	Principal Investigator 血液腫瘍学 / 分子標的療法 / 分子標的治療 / p53 / Chk1 / 分子標的薬 / 細胞周期チェックポイント / 造血器腫瘍 / 白血病 / 低分子量G蛋白 … More / 低分子量Gタンパク質 / BCR/ABL / Ph陽性白血病 / ミトコンドリア膜電位 / ROS産生 / 悪性リンパ腫 / BCL6遺伝子 Less

Development of novel therapeutic strategy against chemotherapy-resistant hematological malignancies by targeting cell cycle checkpoint mechanismsPrincipal Investigator
- Principal Investigator
  
  Kurosu Tetsuya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
Therapeutic target of small GTPase for Ph positive leukemiasPrincipal Investigator
- Principal Investigator
  
  KUROSU Tetsuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
BCL6による悪性リンパ腫細胞のアポトーシス抑制機構の解明と新規治療法の開発Principal Investigator
- Principal Investigator
  
  黒須哲也
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University

All 2016 2015 2014 2013 2012 2011 2010 2006 2005 2004 Other

All Journal Article Presentation

[Journal Article] Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells2016
- Author(s)
  Umezawa Y, Kurosu T, Akiyama H, Wu N, Nogami A, Nagao T and Miura O
- Journal Title
  
  Oncotarget
  
  Volume: 7 Issue: 28 Pages: 44448-44461
- DOI
  10.18632/oncotarget.9844
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461416, KAKENHI-PROJECT-15K09467
[Journal Article] Refractory primary myeloid sarcoma of the breast with MLL-AF9 rearrangement2016
- Author(s)
  Uchida E, Watanabe K, Oshikawa G, Sakashita C, Kurosu T, Fukuda T, Arai A, Murakami N, Miura O and Yamamoto M
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 57 Issue: 1 Pages: 47-51
- DOI
  10.11406/rinketsu.57.47
- NAID
  130005125837
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461416
[Journal Article] Evaluation of the efficacy of maintenance therapy for low-to-intermediate-risk acute promyelocytic leukemia in molecular remission: A retrospective single-institution study.2015
- Author(s)
  Yamamoto M, Okada K, Akiyama H, Kurosu T, Miura O.
- Journal Title
  
  Mol Clin Oncol.
  
  Volume: 3 Issue: 2 Pages: 449-453
- DOI
  10.3892/mco.2014.476
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461416
[Journal Article] FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia.2015
- Author(s)
  Nogami A, Oshikawa G, Okada K, Fukutake S, Umezawa Y, Nagao T, Kurosu T, Miura O.
- Journal Title
  
  Oncotarget.
  
  Volume: 6 Pages: 9189-9205
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461416
[Journal Article] A novel MYD88 mutation, L265RPP, in Waldenstrom macroglobulinemia activates the NF-κB pathway to up regulate Bcl-xL expression and enhances cell survival.2015
- Author(s)
  Nagao T, Oshikawa G, Ishida S, Akiyama H, Umezawa Y, Nogami A, Kurosu T, Miura O.
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461416
[Journal Article] A novel MYD88 mutation, L265RPP, in Waldenstrom macroglobulinemia activates the NF-kappaB pathway to upregulate Bcl-xL expression and enhances cell survival2015
- Author(s)
  Nagao T, Oshikawa G, Ishida S, Akiyama H, Umezawa Y, Nogami A, Kurosu T and Miura O
- Journal Title
  
  Blood cancer journal
  
  Volume: 5 Issue: 5 Pages: 315-317
- DOI
  10.1038/bcj.2015.36
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09467, KAKENHI-PROJECT-26461416
[Journal Article] LT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia2015
- Author(s)
  Nogami A, Oshikawa G, Okada K, Fukutake S, Umezawa Y, Nagao T, Kurosu T and Miura O
- Journal Title
  
  Oncotarget
  
  Volume: 6 Issue: 11 Pages: 9189-9205
- DOI
  10.18632/oncotarget.3279
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461416
[Journal Article] Therapy-related Leukemia with Inv(16)(p13.1q22) and Type D <i>CBFB/MYH11</i> Developing after Exposure to Irinotecan-containing Chemoradiotherapy2015
- Author(s)
  Akiyama H, Yamamoto M, Sakashita C, Umezawa Y, Kurosu T, Murakami N, Miura O.
- Journal Title
  
  Intern. Med.
  
  Volume: 54 Issue: 6 Pages: 651-655
- DOI
  10.2169/internalmedicine.54.3535
- NAID
  130004903073
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461416
[Journal Article] Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.2014
- Author(s)
  Nagao T, Kurosu T, Umezawa Y, Nogami A, Oshikawa G, Tohda S, Yamamoto M, Miura O
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e84746-e84746
- DOI
  10.1371/journal.pone.0084746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591384, KAKENHI-PROJECT-24790966, KAKENHI-PROJECT-26461416
[Journal Article] PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positiveleukemia cells2013
- Author(s)
  Wu N, Kurosu T, Oshikawa G, Nagao T,Miura O
- Journal Title
  
  Int J Oncol
  
  Volume: 42(2) Issue: 2 Pages: 419-28
- DOI
  10.3892/ijo.2012.1729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030, KAKENHI-PROJECT-24591384, KAKENHI-PROJECT-24790966
[Journal Article] Recurrence of Chronic Active Epstein-Barr Virus Infection from Donor Cells after Achieving Complete Response Through Allogeneic Bone Marrow Transplantation2012
- Author(s)
  Arai A, et al
- Journal Title
  
  Intern. Med.
  
  Volume: 51 Issue: 7 Pages: 777-782
- DOI
  10.2169/internalmedicine.51.6769
- NAID
  130002061847
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590430, KAKENHI-PROJECT-22591030
[Journal Article] Recurrenceof chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation2012
- Author(s)
  Arai A, Imadome K, Wang L, Wu N, Kurosu T, Wake A, Yamamoto H, Ota Y, Harigai M, Fujiwara S,Miura O
- Journal Title
  
  Intern Med
  
  Volume: 51(7) Pages: 777-82
- URL
  http://dx.doi.org/10.2169/internalmedicine.51.6769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030
[Journal Article] c-Cbl and Cbl-b ligases mediate17-allylaminodemethoxygeldanamycin-indu ced degradation of autophosphorylated Flt3 kinase with internal tandemduplication through the ubiquitin proteasome pathway2011
- Author(s)
  Oshikawa G, Nagao T, Wu N, Kurosu T,Miura O
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Issue: 35 Pages: 30263-30273
- DOI
  10.1074/jbc.m111.232348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030
[Journal Article] DNA damage stress and inhibitionof Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3beta2011
- Author(s)
  Nagao T, Oshikawa G, Wu N, Kurosu T,Miura O
- Journal Title
  
  PLoS ONE
  
  Volume: 6 Issue: 11 Pages: e27397-e27397
- DOI
  10.1371/journal.pone.0027397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030
[Journal Article] DNA damage stress and inhibition of Jak2-V617F cause its degradation and synergistically induce apoptosis through activation of GSK3beta2011
- Author(s)
  Nagao T, Oshikawa G, Wu N, Kurosu T, Miura O
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030
[Journal Article] BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway2010
- Author(s)
  Kurosu T, Wu N, Oshikaw G, Kagechika H, Miura O
- Journal Title
  
  Apoptosis
  
  Volume: 15 Pages: 608-620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030
[Journal Article] Clonal evolution with double Ph followed by tetraploidy in imatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation2010
- Author(s)
  Oshikawa G, Kurosu T, Arai A,Murakami N,Miura O
- Journal Title
  
  Cancer Genet Cytogenet
  
  Volume: 199 Issue: 1 Pages: 56-61
- DOI
  10.1016/j.cancergencyto.2010.01.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030
[Journal Article] Enhancementof imatinib-inducedapoptosis ofBCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway2010
- Author(s)
  Kurosu T, Wu N, Oshikawa G, KagechikaH,Miura O
- Journal Title
  
  Apoptosis
  
  Volume: 15 Issue: 5 Pages: 608-620
- DOI
  10.1007/s10495-010-0457-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030
[Journal Article] Clonal evolution with double Ph followed by tetraploidy inimatinib-treated chronic myeloid leukemia with e19a2 transcript in transformation2010
- Author(s)
  Oshikawa G, Kurosu T, AraiA, Murakami N, Miura O
- Journal Title
  
  Cancer Genet Cytogenet
  
  Volume: 199 Pages: 56-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030
[Journal Article] BCR/ABL and IL-3 activate Rap 1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion2006
- Author(s)
  Aishun Jin, Tetsuya Kurosu, Kana Tsuji, Daisuke Mizuchi, Ayako Arai, Harumi Fujita, Masakazu Hattori, Nagahiro Minato, Osamu Miura
- Journal Title
  
  Oncogene (in press)
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] Reactive oxygen species generated by hematopoietic cytokines play roles in activation of receptor-mediated signaling and in cell cycle progression2006
- Author(s)
  Iiyama, M., Kakihana, K., Kurosu, T., Miura, O.
- Journal Title
  
  Cell Signa 18
  
  Pages: 174-182
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] p38 MAP kinase plays a role in G2 checkpoint activation and inhibits apoptosis of human B cell lymphoma cells treated with etoposide2005
- Author(s)
  T.Kurosu, Y.Takahashi, T.Fukuda, T.Koyama, T.Miki, O.Miura
- Journal Title
  
  Apoptosis 10
  
  Pages: 1111-1120
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in imatinib-resistant chronic myelogenous leukemia2005
- Author(s)
  Masahide Yamamotoa, Kazuhiko Kakihanaa, Tetsuya Kurosua, Naomi Murakamib, Osamu Miura
- Journal Title
  
  Cancer Genetics and Cytogenetics 157
  
  Pages: 104-108
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis2005
- Author(s)
  Zhen-Hua Jin 1, Tetsuya Kurosu 1, Mitsuko Yamaguchi 1, Ayako Arai 1, Osamu Miura^*
- Journal Title
  
  Oncogene
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in imatinib-resistant chronic myelogenous leukemia2005
- Author(s)
  Masahide Yamamotoa, Kazuhiko Kakihanaa, Tetsuya Kurosua, Naomi Murakamib, Osamu Miuraa
- Journal Title
  
  Cancer Genetics and Cytogenetics 157
  
  Pages: 104-108
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis2005
- Author(s)
  Zhen-Hua Jin, Tetsuya Kurosu, Mitsuko Yamaguchi, Ayako Arai, Osamu Miura
- Journal Title
  
  Oncogene
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells2005
- Author(s)
  Daisuke Mizuchi, Tetsuya Kurosu, Aiko Kida, Zhen-Hua Jin, Aishun Jin, Ayako Arai, Osamu Miura
- Journal Title
  
  Biochemical and Biophysical Research Communications 326
  
  Pages: 645-651
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] Fluid retention during arsenic trioxide treatment in acute promyelocytic leukemia2005
- Author(s)
  Arai, A., Kitano, A., Kurosu, T., Yamamoto, K., Miki, T., Murakami, N., Miura, O.
- Journal Title
  
  Am J Hematol 79
  
  Pages: 247-248
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] The two major imatinib resistance mutations E255K and T315I enhance the activity or BCR/ABL fusion kinase2004
- Author(s)
  Masahide Yamamoto, Tetsuya Kurosu, Kazuhiko Kakihana, Daisuke Mizuchi, Osamu Miura
- Journal Title
  
  Biochemical and Biophysical Research Communications 319
  
  Pages: 1272-1275
- Data Source
  KAKENHI-PROJECT-16790532
[Journal Article] p38 MAP kinase plays a role in G2 checkpoint activation and inhibits apoptosis of human B cell lymphoma cells treated with etoposide
- Author(s)
  T.Kurosu, Y.Takahashi, T.Fukuda, T.Koyama, T.Miki, O.Miura
- Journal Title
  
  APOPTOSIS (in press)
- Data Source
  KAKENHI-PROJECT-16790532
[Presentation] PECAM-1 による PI3K/Akt/mTORC1 経路を介した SDF-1 誘導性走化能の亢進機構2016
- Author(s)
  梅澤佳央、秋山弘樹、岡田啓吾、石田信也、野上彩子、押川学、黒須哲也、三浦修
- Organizer
  第 78 回日本血液学会学術集会
- Place of Presentation
  神奈川県、横浜市
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26461416
[Presentation] Pim キナーゼによる mTOR 経路促進を介した FLT3-ITD による Bortezomib 抵抗性獲得機構2016
- Author(s)
  野上彩子、岡田啓五、押川学、石田信也、秋山弘樹、梅澤佳央、黒須哲也、三浦修
- Organizer
  第 78 回日本血液学会学術集会
- Place of Presentation
  神奈川県、横浜市
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-26461416
[Presentation] PECAM - 1 enhances SDF-1-induced chemotaxis mediated through activa- tion of the PI3K/Akt/mTORC1 pathway2015
- Author(s)
  Yoshihiro Umezawa, Hiroki Akiyama, Keigo Okada, Shinya Ishida, Ayako Nogami, Gaku Oshikawa, Tetsuya Kurosu, Osamu Miura
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県金沢市石川県立音楽堂
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26461416
[Presentation] PECAM-1 enhances SDF-1-induced chemotaxis mediated through activation of the PI3K/Akt/mTORC1 pathway.2014
- Author(s)
  Yoshihiro Umezawa, Hiroki Akiyama, Shinya Ishida, Ayako Nogami, Gaku Oshikawa, Toshikage Nagao, Tetsuya Kurosu, Osamu Miura
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26461416
[Presentation] FLT3-ITD confers resistance to PI3K/Akt inhibitors by protecting mTOR/eIF4F/Mcl-1 pathway via STAT5.2014
- Author(s)
  Ayako Nogami, Gaku Oshikawa, Shinya Ishida, Hiroki Akiyama, Yoshihiro Umezawa, Toshikage Nagao, Tetsuya Kurosu, Osamu Miura.
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-26461416
[Presentation] Interplay between Chk1-and p53-mediated checkpoint signaling in BCR/ABL-expressing cells2012
- Author(s)
  Kurosu T, Wu N, Nogami A, Oshikawa G, Nagao T, Miura O.
- Organizer
  第74 回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Molecularmechanisms for differential responses of Flt3-ITD and -TKD to molecular targeted therapy2012
- Author(s)
  Oshikawa G, Nagao T, Nogami A, Wu N, Kurosu T, Miura O
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Interplay between Chk1-and p53-mediated checkpoint signaling in BCR/ABL-expressing cells2012
- Author(s)
  Kurosu T, Wu N, Nogami A, OshikawaG, Nagao T, Miura O
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Molecular mechanisms for differential responses of Flt3-ITD and –TKD to molecular targeted therapy2012
- Author(s)
  Oshikawa G, Nagao T, Nogami A, Wu N, Kurosu T, Miura O.
- Organizer
  第74 回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Aberrant signaling thatinvolves Jak2-V617F and Lyn in a newly established leukemia cell line, PV-T12012
- Author(s)
  Nagao T, Yamamoto M, Oshikawa G, Nogami A, Wu N, Kurosu T, Tohda S, Miura O
- Organizer
  第74回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Aberrant signaling that involves Jak2-V617F and Lyn in a newly established leukemia cell line, PV-T12012
- Author(s)
  Nagao T, Yamamoto M, Oshikawa G, Nogami A, Wu N, Kurosu T, Tohda S, Miura O
- Organizer
  第74 回日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] PECAM-1 possibly mediates BCR/ABL signaling and modulates imatinib sensitivity of Ph+ leukemic cells2011
- Author(s)
  Wu N, Kurosu T, Oshikawa G, Nagao T, Miura O
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] PECAM-1 possibly mediates BCR/ABL signaling and modulates imatinib sensitivity of Ph+leukemic cells2011
- Author(s)
  Wu N, Kurosu T, Oshikawa G, Nagao T, Miura O
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Inhibition of Jak2-V617F under DNA-damage stress induces its degradation and synergislic apoptosis2011
- Author(s)
  Nagao T, Oshikawa G, Wu N, Kurosu T, Miura O
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] c-Cbl and Cbl-b mediate 17-AAG-induced Flt3-ITD degradation through the ubiquitin proteasome pathway2011
- Author(s)
  Oshikawa G, Nagao T, Wu N, Kurosu T, Miura O
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Inhibition of BCR/ABL downregulates Chk1 to induce apoptosis synergistically with chemotherapeutics2011
- Author(s)
  Kurosu T, Wu N, Oshikawa G, Nagao T, Miura O
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Inhibition of BCR/ABL downregulates Chk1 to induce apoptosis synergislically with chemotherapeutics2011
- Author(s)
  Kurosu T, Wu N, Oshikawa G, Nagao T, Miura O
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Inhibition of Jak2-V617F under DNA-damage stress induces its degradation and synergistic apoptosis2011
- Author(s)
  Nagao T, Oshikawa G, Wu N, Kurosu T, Miura O
- Organizer
  第73回日本血液学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Roles for PECAM-1(CD31) in signa ling from and leukemogenesis by BCR/ABL2010
- Author(s)
  Wu N, Kurosu T, Suzuki T, Oshikawa G, Nagao T, Miura O
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] c-Cbl-mediated ubiquitination of Flt3-ITD and cellular mechanisms regulat ing its degradation2010
- Author(s)
  Oshikawa G, Wu N, Nagao T, Suzki T, Kurosu T, Miura O
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Molecular mechanismsregulating DNA damage-induced degradation of Jak2-V617F and apoptosis2010
- Author(s)
  Nagao T, Wu N, Oshikawa G, Suzuki T, Kurosu T, Miura O
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Chemotherpy resistance through enhanced Chkl activat ion by BCR/ABL, Flt-ITD and Jak2-V617F2010
- Author(s)
  Kurosu T, Wu N, Suzuki T, Oshikawa G, Nagao T, Miura O
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] c-Cbl-mediated ubiquitination of Flt3-ITD and cellularmechanisms regulating its degradation2010
- Author(s)
  Oshikawa G, Wu N, Nagao T, Suzki T, Kurosu T, Miura O
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Roles for PECAM-1 (CD31) in signaling from andleukemogenesis by BCR/ABL2010
- Author(s)
  Wu N, Kurosu T, Suzuki T, Oshikawa G, Nagao T, Miura O
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Chemotherpy resistance through enhanced Chk1activation by BCR/ABL, Flt-ITD and Jak2-V67F2010
- Author(s)
  Kurosu T, Wu N, Suzuki T, Oshikawa G, Nagao T,Miura O
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591030
[Presentation] Molecular mechanisms regulating DNA damage-induced degradation of Jak2-V617F and apoptosis2010
- Author(s)
  Nagao T, Wu N, Oshikawa G, Suzuki T, Kurosu T, Miura O
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591030

1. 三浦修

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kurosu Tetsuya 黒須 哲也

KUROSU Tetsuya 黒須 哲也

黒須 哲也 クロス テツヤ

Research Projects

Research Products

Co-Researchers

Development of novel therapeutic strategy against chemotherapy-resistant hematological malignancies by targeting cell cycle checkpoint mechanismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic target of small GTPase for Ph positive leukemiasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

BCL6による悪性リンパ腫細胞のアポトーシス抑制機構の解明と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Down regulation of Chk1 by p53 plays a role in synergistic induction of apoptosis by chemotherapeutics and inhibitors for Jak2 or BCR/ABL in hematopoietic cells2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Refractory primary myeloid sarcoma of the breast with MLL-AF9 rearrangement2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Evaluation of the efficacy of maintenance therapy for low-to-intermediate-risk acute promyelocytic leukemia in molecular remission: A retrospective single-institution study.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia.2015

Author(s)

Journal Title

Data Source

[Journal Article] A novel MYD88 mutation, L265RPP, in Waldenstrom macroglobulinemia activates the NF-κB pathway to up regulate Bcl-xL expression and enhances cell survival.2015

Author(s)

Journal Title

Data Source

[Journal Article] A novel MYD88 mutation, L265RPP, in Waldenstrom macroglobulinemia activates the NF-kappaB pathway to upregulate Bcl-xL expression and enhances cell survival2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemia2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapy-related Leukemia with Inv(16)(p13.1q22) and Type D <i>CBFB/MYH11</i> Developing after Exposure to Irinotecan-containing Chemoradiotherapy2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positiveleukemia cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Recurrence of Chronic Active Epstein-Barr Virus Infection from Donor Cells after Achieving Complete Response Through Allogeneic Bone Marrow Transplantation2012

Author(s)

Kurosu Tetsuya 黒須哲也

KUROSU Tetsuya 黒須哲也

黒須哲也クロステツヤ