Tagami Shinji 田上真次

… Alternative Names

田上真次タガミシンジ

TAGAMI Shinji 田上真次

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Researcher Number	40362735
Other IDs
External Links
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪大学, キャンパスライフ健康支援・相談センター, 特任教授 2015 – 2019: 大阪大学, 医学系研究科, 助教 2015: 大阪大学, 医学研究科, 助教 2011 – 2015: 大阪大学, 医学(系)研究科(研究院), 助教 2014: 大阪大学, 大学院医学系研究科, 助教 … More 2007 – 2011: Osaka University, Graduate School of Medicine, Assistant Professor 2010: Osaka University, 大学院・医学系研究科, 助教 2007: 大阪大学, 医学系・研究科, 助教 2004 – 2006: 大阪大学, 医学系研究科, 助手 Less
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related
Keywords	Principal Investigator BACE / γセクレターゼ / アルツハイマー病 / cell-free BACE assay / ガンマセクレターゼ / プレセニリン / Alzheimer disease / gamma secretase / アミロイドベータの分解 / バイオマーカー … More / アルツハイマー病バイオマーカー / APL1β / アミロイドβ / APLP1 / アミロイドベータ / amyloid beta / presenilin / タウ蛋白 / アミロイドβ42 / amvloid beta / Presenilin / γ-secretase / Aβ degradation / )cell-free BACE assay / 脳神経疾患 / γ切断 / βAPP / GSM / Notch-1 / Notchシグナル / MCSF / beta APP / betaAPP … More Except Principal Investigator アルツハイマー病 / Notch-1 / アミロイドβ蛋白 / Alzheimer disease / プレセニリン / γセクレターゼ / バイオマーカー / NSAID / Notch signaling / γ切断 / βアミロイド蛋白前駆体 / Notchシグナル伝達 / アミロイドβ / アミロイド / 神経変性疾患 / 質量分析 / 精神神経科学 / 脳脊髄液 / 老人斑 / FAM63B / SLC6A4 / DNAメチル化 / 双極性障害 / 大脳基底核 / 5-fC / 5-hmC / 5-mC / 患者細胞 / アミロイドβペプチド / ゲノム編集技術 / iPS技術 / Treatment / micro glia / Inflammation / イブプロフェン / ワクチン療法 / マイクログリア / 抗炎症剤 / apoptosis / cerebral ischemia / chaperone / APP / amyloid apoptosis / endoplasmic reticulum stress / アポトーシス / 脳虚血 / 分子シャペロン / アミロイド前駆蛋白(APP) / アミロイド蛋白(Aβ) / 小胞体(ER)ストレス / gamma-cleavage / beta-amyloid protein precursor / Amyloid-beta peptide / gamma-secretase / Presenilin / γ-cleavage / βAPP / Amyloid-β peptide / γ-secretase / presenilin / Alzheimer's disease / γ‐セクレターゼ / CRISPR/CAS9 / γ-セクレターゼ / 膜内タンパク分解 / Aβ / 酵素と基質の解離 / 膜内蛋白分解 / APL1ベータペプチド / アミロイドベータ産生機構 / CHIP / ユビキチン / タウ / 小胞体ストレス / タウオパチー / 脳神経疾患 / セクレターゼ / 超微量物質定量 / プロテオームリサーチ / LC/MS/MS / 精神疾患 / アミノ酸配列決定 / ペプチド / 質量分析解析 / 精神神経疾 / 疾患関連物質探索 / 質量分析法 / 精神神経疾患 / サロゲートマーカー / 不溶性蛋白 / APLP1 / Notch1 Less

Development of Alzheimer disease biomarkerPrincipal Investigator
- Principal Investigator
  
  田上真次
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Osaka University
双極性障害エピゲノムマーカーと薬剤反応性についての検討
- Principal Investigator
  
  菅原裕子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Fukuoka University
  Osaka University
幹細胞技術と遺伝子編集技術を組み合わせアルツハイマー病治療戦略を洗練させる
- Principal Investigator
  
  大河内正康
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Intramembrane proteolysis of beta-APP in a gamma-secretase independent mechanism
- Principal Investigator
  
  Yanagida Kanta
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Mechanism of presenilin/gamma secretase to produce amyloid betaPrincipal Investigator
- Principal Investigator
  
  Tagami Shinji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Identification of molecules related to modulation of Amyloid beta production in human cerebrospinal fluid (CSF)
- Principal Investigator
  
  Takashi Kodama
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Increase in Abeta42 production and accelerated dissociation of Abeta42 from gamma-secretase
- Principal Investigator
  
  Okochi Masayasu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Pathogenesis of tauopathies in terms of protein quality control mechanism
- Principal Investigator
  
  KUDO Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Analysis of presenilin gamma-secretase function on Abeta and NICD generationPrincipal Investigator
- Principal Investigator
  
  TAGAMI Shinji
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Analysis of novel Alzheimer's disease-related peptides in human cerebrospinal fluid derived from APLP2
- Principal Investigator
  
  YANAGIDA Kanta
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Mass spectrometry analysis of human cerebrospinal fluid with psychiatric disease patients.
- Principal Investigator
  
  OKOCHI Masayasu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Development of methods to promote degradation of amyloid betaPrincipal Investigator
- Principal Investigator
  
  TAGAMI Shinji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Characterization of Abeta-like peptide other in brains of Alzheimer disease
- Principal Investigator
  
  MASAYASU Okochi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Characterization of BACE-mediated proteolysis including amyloid-betaPrincipal Investigator
- Principal Investigator
  
  TAGAMI Shinji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
The mechanisms of anti-Alzheimer dicaam effects by NSAIDs
- Principal Investigator
  
  TAKASHI Morihara
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Analysis of sequential endoproteolytic process of beta-APP to establish novel therapeutic interventions
- Principal Investigator
  
  TAKEDA Masatoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Implication of ER stress in amyloid production and its application for therapeutic approach
- Principal Investigator
  
  KUDO Takashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Degradation of amyloid-betaPrincipal Investigator
- Principal Investigator
  
  TAGAMI Shinji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University
Measurement of novel Nβ species level as a substitute for Aβ species.
- Principal Investigator
  
  OKOCHI Masayasu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Osaka University

[Book] アルツハイマー病Abeta42のサロゲートマーカーAPL1beta28ペプチドの発見:孤発性アルツハイマー病患者脳でAbeta42の産生増大が起こっている可能性について2010
- Author(s)
  大河内正康、田上真次、柳田寛太、武田雅俊
- Publisher
  日本神経精神薬理学雑誌
- Data Source
  KAKENHI-PROJECT-22591284
[Book] 老年期うつ病家庭医学大全科2010
- Author(s)
  田上真次, 武田雅俊
- Publisher
  法研
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 新老年学第3版アルツハイマー型認知症2010
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 興奮・暴力疾患と治療III2010
- Author(s)
  田上真次, 武田雅俊
- Total Pages
  217
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 新規脳内ペプチドAPL1beta28の測定結果からアルツハイマー病をみる2010
- Author(s)
  大河内正康、田上真次、柳田寛太、武田雅俊
- Publisher
  メディカルレビュー社 Pharma Medica
- Data Source
  KAKENHI-PROJECT-22591284
[Book] 神経内科第72巻特別増刊号認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発 (Aβカスケード、神経栄養因子、神経伝達物質)2010
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Total Pages
  5
- Publisher
  科学評論者
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 神経内科第72巻特別増刊号認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発(Aβカスケード、神経栄養因子、神経伝達物質)2010
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Publisher
  科学評論者
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 老年期うつ病家庭医学大全科2010
- Author(s)
  田上真次, 武田雅俊
- Publisher
  法研
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 新老年学第3版アルツハイマー型認知症2010
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Total Pages
  9
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-20591405
[Book] 興奮・暴力疾患と治療III2010
- Author(s)
  田上真次, 武田雅俊
- Total Pages
  217
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-20591405
[Book] Psychiatry Today, No. 25 Alzheimer's Association 2009 International Conference on Alzheimer's disease (ICAD2009) に参加して2010
- Author(s)
  田上真次
- Total Pages
  1
- Publisher
  Psychiatry Today
- Data Source
  KAKENHI-PROJECT-20591405
[Book] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Okochi, M., Tagami, S., Takeda, M
- Total Pages
  94
- Publisher
  Annual Report of Osaka University Academic Achievement 2007-2008
- Data Source
  KAKENHI-PROJECT-19591352
[Book] 第10回国際アルツハイマー病学会に参加して学会印象記2008
- Author(s)
  田上真次
- Total Pages
  18
- Publisher
  Psychiatry Today
- Data Source
  KAKENHI-PROJECT-18591285
[Book] プレセニリンγセクレターゼによる切断の多様性とその変化について2008
- Author(s)
  田上真次大河内正康福森亮雄武田雅俊
- Total Pages
  4
- Publisher
  分子精神医学先端医学社
- Data Source
  KAKENHI-PROJECT-20591405
[Book] プレセニリンγセクレターゼによる切断の多様性とその変化について2008
- Author(s)
  田上真次, 大河内正康, 福森亮雄, 武田雅俊
- Publisher
  分子精神医学先端医学社
- Data Source
  KAKENHI-PROJECT-20591405
[Book] アンチエイジングと精神医学2007
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Publisher
  Journal of Otolaryngology, Head and Neck Surgery東京医学社
- Data Source
  KAKENHI-PROJECT-18591285
[Book] 脳と循環2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Total Pages
  13
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Book] 老年期認知症ナビゲーター2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Total Pages
  2
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Book] 脳と循環2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Total Pages
  13
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17390318
[Book] 老年期認知症ナビゲーター2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Total Pages
  2
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17390318
[Book] BACEによるアミロイドベータ蛋白の切断について2006
- Author(s)
  田上真次, 大河内正康, 武田雅俊ほか
- Total Pages
  230
- Publisher
  精神薬療研究年報第38集
- Data Source
  KAKENHI-PROJECT-18591285
[Book] 研修医の精神科研修ハンドブック(アルツハイマー型痴呆)2005
- Author(s)
  田上真次, 武田雅俊
- Total Pages
  8
- Data Source
  KAKENHI-PROJECT-16591132
[Book] 研修医の精神科研修ハンドブック2005
- Author(s)
  田上真次, 武田雅俊
- Total Pages
  8
- Publisher
  アルツハイマー型痴呆
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Book] 痴呆とうつ心療内科2005
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Publisher
  科学評論社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Book] Molecular Medicine 41 Aβの毒性発現機構2004
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA2024
- Author(s)
  Uozumi Ryota、Mori Kohji、Gotoh Shiho、Miyamoto Tesshin、Kondo Shizuko、Yamashita Tomoko、Kawabe Yuya、Tagami Shinji、Akamine Shoshin、Ikeda Manabu
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 3 Pages: 109303-109303
- DOI
  10.1016/j.isci.2024.109303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19492, KAKENHI-PROJECT-22K07559, KAKENHI-PROJECT-22KJ2148
[Journal Article] eIF5 stimulates the CUG initiation of RAN translation of poly-GA dipeptide repeat protein (DPR) in C9orf72 FTLD/ALS2024
- Author(s)
  Gotoh Shiho、Mori Kohji、Fujino Yuzo、Kawabe Yuya、Yamashita Tomoko、Omi Tsubasa、Nagata Kenichi、Tagami Shinji、Nagai Yoshitaka、Ikeda Manabu
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 300 Issue: 3 Pages: 105703-105703
- DOI
  10.1016/j.jbc.2024.105703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19492, KAKENHI-PROJECT-22K07559, KAKENHI-PROJECT-19K17111, KAKENHI-PROJECT-22KJ2148, KAKENHI-PROJECT-21H02840
[Journal Article] APLP2 is predominantly cleaved by β-secretase and γ-secretase in the human brain2023
- Author(s)
  Yanagida K, Maruyama R, Tagami S, Kudo T, Okochi M, Fukumori A.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 23 Issue: 2 Pages: 311-318
- DOI
  10.1111/psyg.12933
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07559, KAKENHI-PROJECT-23K10903
[Journal Article] RNA Dysmetabolism and Repeat-Associated Non-AUG Translation in Frontotemporal Lobar Degeneration/Amyotrophic Lateral Sclerosis due to <i>C9orf72</i> Hexanucleotide Repeat Expansion2023
- Author(s)
  Kohji Mori, Shiho Gotoh, Ryota Uozumi, Tesshin Miyamoto, Shoshin Akamine, Yuya Kawabe, Shinji Tagami, Manabu Ikeda
- Journal Title
  
  JMA Journal
  
  Volume: 6 Issue: 1 Pages: 9-15
- DOI
  10.31662/jmaj.2022-0160
- ISSN
  2433-328X, 2433-3298
- Year and Date
  2023-01-16
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19492, KAKENHI-PROJECT-20H03602, KAKENHI-PROJECT-22KJ2148, KAKENHI-PROJECT-22K07559
[Journal Article] Identification of small peptides in human cerebrospinal fluid upon amyloid-βdegradation2017
- Author(s)
  Mizuta N, Yanagida K, Kodama T, Tomonaga T, Takami M, Oyama H, Kudo T, Ikeda M, Takeda M, Tagami S, Okochi M
- Journal Title
  
  Neurodegener Dis
  
  Volume: 17 Issue: 2-3 Pages: 103-109
- DOI
  10.1159/000453358
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24249100, KAKENHI-PROJECT-26461746
[Journal Article] Semagacestat Is a Pseudo-Inhibitor of γ-Secretase2017
- Author(s)
  Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, Ihara Y, Okochi M.
- Journal Title
  
  Cell Rep
  
  Volume: 21 Issue: 1 Pages: 259-273
- DOI
  10.1016/j.celrep.2017.09.032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10213, KAKENHI-PROJECT-17K10299, KAKENHI-PROJECT-16H05379, KAKENHI-PROJECT-26461745
[Journal Article] 最新のアルツハイマー病の血液バイオマーカー開発2016
- Author(s)
  田上　真次　大河内　正康
- Journal Title
  
  医学のあゆみ
  
  Volume: 257 Pages: 519-524
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461746
[Journal Article] 認知症のバイオマーカー　―髄液ならびに血液―2016
- Author(s)
  田上　真次　大河内　正康
- Journal Title
  
  臨床精神医学
  
  Volume: 45 Pages: 405-410
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461746
[Journal Article] Absolute Quantitation of Low Abundance Plasma APL1βpeptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment2014
- Author(s)
  Sano S, Tagami S, Hashimoto Y, Yoshizawa-Kumagaye K, Tsunemi M, Okochi M, Tomonaga T
- Journal Title
  
  J Proteome Res
  
  Volume: Vol.13 Pages: 1012-1020
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor2014
- Author(s)
  Omi T, Tanimukai H, Kanayama D, Sakagami Y, Tagami S, Okochi M, Morihara T, Sato M, Yanagida K, Kitasyoji A, Hara H, Imaizumi K, Maurice T, Chevallier N, Marchal S, Takeda M, Kudo T
- Journal Title
  
  Cell Death and Disease
  
  Volume: 5 Issue: 7 Pages: 1-11
- DOI
  10.1038/cddis.2014.301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25461729, KAKENHI-PROJECT-26461746
[Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-βaccumulation modifier2014
- Author(s)
  Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, Kudo T, Hashimoto R, Itoh N, Nishitomi K, Yamaguchi-Kabata Y, Tsunoda T, Takamura H, Katayama T, Kimura R, Kamino K, Hashizume Y, Takeda M
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: Vol.111 Pages: 2638-2643
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as as amyloid beta accumulation modifier2014
- Author(s)
  Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
- Journal Title
  
  Proc. Acad. Natl. Sci. USA
  
  Volume: 111 Issue: 7 Pages: 2638-2643
- DOI
  10.1073/pnas.1307345111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-23791332, KAKENHI-PROJECT-24591708, KAKENHI-PROJECT-24591709, KAKENHI-PROJECT-25290039, KAKENHI-PROJECT-25293250, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26293010, KAKENHI-PROJECT-26461746, KAKENHI-PROJECT-26461747
[Journal Article] Relative Ratio and Level of Amyloid-β 42 Surrogate in Cerebrospinal Fluid of Familial Alzheimer Disease Patients with Presenilin 1 Mutations2014
- Author(s)
  Tagami et al.
- Journal Title
  
  Neurodegenerative Disease
  
  Volume: 13 Issue: 2-3 Pages: 166-170
- DOI
  10.1159/000355258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591234, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-26461746
[Journal Article] γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.2014
- Author(s)
  Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Issue: 8 Pages: 51095121-51095121
- DOI
  10.1074/jbc.m113.510131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-24500433
[Journal Article] γ-Secretase associated with lipid rafts : multiple interactive pathways in the stepwise processing ofβ-carboxyl-terminal fragment2014
- Author(s)
  Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M
- Journal Title
  
  J Biol Chem
  
  Volume: Vol.289 Pages: 5109-5121
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ432013
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M
- Journal Title
  
  Cell Reports
  
  Volume: Vol.3 Pages: 42-51
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Absolute Quantitation of Low Abundance Plasma APL1β peptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment.2013
- Author(s)
  Sano S, Tagami S, Hashimoto Y, Yoshizawa-Kumagaye K, Tsunemi M, Okochi M, Tomonaga T.
- Journal Title
  
  J Proteome Res.
  
  Volume: 13 Issue: 2 Pages: 10121020-10121020
- DOI
  10.1021/pr4010103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-24659622, KAKENHI-PROJECT-25290054
[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia.2013
- Author(s)
  Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M.
- Journal Title
  
  World J Biol Psychiatry
  
  Volume: 14 Pages: 100-13
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43.2013
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
- Journal Title
  
  Cell Rep.
  
  Volume: 3(1) Issue: 1 Pages: 42-51
- DOI
  10.1364/oe.21.000322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] γ-Secretase Modulators and Presenilin 1 Mutants Act Differently on Presenilin/γ-Secretase Function to Cleave Aβ42 and Aβ43.2013
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M.
- Journal Title
  
  Cell Reports
  
  Volume: 3 Pages: 4251-4251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] γ -secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ432013
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takami M,Kodama TS, Mori K, Nakayama T, Ihara Y,Takeda M
- Journal Title
  
  Cell Rep
  
  Volume: 3 Pages: 42-51
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.2011
- Author(s)
  Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 415 Issue: 3 Pages: 519-525
- DOI
  10.1016/j.bbrc.2011.10.113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] PERK/eIF2α/ATF4 pathway and execute protective function in ER stress.2011
- Author(s)
  Sigma-1Rs are upregulated via Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 415 Pages: 519-25
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Association study of KIBRA gene with memory performance in a Japanese population.2011
- Author(s)
  Yasuda Y, Hashimoto R, Ohi K, Fukumoto M, Takamura H, Iike N, Yoshida T, Hayashi N, Takahashi H, Yamamori H, Morihara T, Tagami S, Okochi M, Tanaka T, Kudo T, Kamino K, Ishii R, Iwase M, Kazui H, Takeda M.
- Journal Title
  
  World J Biol Psychiatry
  
  Volume: 11 Pages: 852-7
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress2011
- Author(s)
  Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 415 Pages: 519-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The AKT1 gene is associated with attention and brain morphology in schizophrenia2011
- Author(s)
  Ohi K, Hashimoto R, Yasuda Y, Fukumoto M, Nemoto K, Ohnishi T, Yamamori H, Takahashi H, Iike N, Kamino K, Yoshida T, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Iwase M, Kazui H, Takeda M
- Journal Title
  
  World J Biol Psychiatry.2011 Dec 12
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011
- Author(s)
  Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
- Journal Title
  
  Psychogeriatrics.
  
  Volume: 11 Issue: 2 Pages: 90-97
- DOI
  10.1111/j.1479-8301.2011.00355.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591703, KAKENHI-PROJECT-23591706
[Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer' s disease in the mild cognitive impairment stage2011
- Author(s)
  Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M.
- Journal Title
  
  Dement Geriatr Cogn Disord Extra
  
  Volume: 1 Issue: 1 Pages: 20-30
- DOI
  10.1159/000323561
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591514, KAKENHI-PROJECT-23591703
[Journal Article] Different characteristics of cognitive impairment in elderly schizophrenia and Alzheimer's disease in the mild cognitive impairment stage2011
- Author(s)
  Kazui H, Yoshida T, Takaya M, Sugiyama H, Yamamoto D, Kito Y, Wada T, Nomura K, Yasuda Y, Yamamori H, Ohi K, Fukumoto M, Iike N, Iwase M, Morihara T, Tagami S, Shimosegawa E, Hatazawa J, Ikeda Y, Uchida E, Tanaka T, Kudo T, Hashimoto R, Takeda M
- Journal Title
  
  Dement Geriatr Cogn Dis Extra
  
  Volume: Vol.1 Pages: 20-30
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death2011
- Author(s)
  Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M
- Journal Title
  
  Psychogeriatrics
  
  Volume: Vol.11 Pages: 90-97
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress2011
- Author(s)
  Mitsuda T, Omi T, Tanimukai H, Sakagami Y, Tagami S, Okochi M, Kudo T, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: Vol.415 Pages: 519-525
- Data Source
  KAKENHI-PROJECT-23591703
[Journal Article] Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death.2011
- Author(s)
  Kato K, Tanaka T, Sadik G, Baba M, Maruyama D, Yanagida K, Kodama T, Morihara T, Tagami S, Okochi M, Kudo T, Takeda M.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 11 Pages: 90-7
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.2010
- Author(s)
  Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, Iwase M, Kamino K, Ishii R, Kazui H, Fukumoto M, Takamura H, Yamamori H, Azechi M, Ikezawa K, Tanimukai H, Tagami S, Morihara T, Okochi M, Yamada K, Numata S, Ikeda M, Tanaka T, Kudo T, Ueno S
- Journal Title
  
  Schizophr Res.
  
  Volume: 116 Pages: 126-32
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients.2010
- Author(s)
  Okochi M, Tagami S, Takeda M
- Journal Title
  
  Neurodegener Dis.
  
  Volume: 7 Pages: 42-5
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
- Author(s)
  Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 10 Pages: 117-123
- NAID
  10029771051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010
- Author(s)
  Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
- Journal Title
  
  BMC Complement Altern Med. 10
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
- Author(s)
  Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, FujiiK, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Take da M.
- Journal Title
  
  Psychogeriatrics.
  
  Volume: 10 Pages: 117-23
- NAID
  10029771051
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
- Author(s)
  Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
- Journal Title
  
  Dement Geriatr Cogn Disord
  
  Volume: 30 Pages: 302-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010
- Author(s)
  Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S,Morihara T, Hashimoto R, Cacabelos R.
- Journal Title
  
  Psychiatry Clin Neurosci 64
  
  Pages: 592-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Human B2 inhibitgamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010
- Author(s)
  Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
- Journal Title
  
  J Biol Chem 285
  
  Pages: 14290-14931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Apolipoprotein E and central nervous system disorders: reviews of clinical findings.2010
- Author(s)
  Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
- Journal Title
  
  Psychiatry Clin Neurosci.
  
  Volume: 64 Pages: 592-607
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
- Author(s)
  Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
- Journal Title
  
  Dement Geriatr Cogn Disord
  
  Volume: 30 Pages: 302-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010
- Author(s)
  Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
- Journal Title
  
  BMC Complement Altern Med.
  
  Volume: 10 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
- Author(s)
  Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
- Journal Title
  
  Psychogeriatrics
  
  Volume: 10 Pages: 117-123
- NAID
  10029771051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Laughter and humor as complementary and alternative medicines for dementia patients.2010
- Author(s)
  Takeda M, Hashimoto R, Kudo T, Okochi M, Tagami S, Morihara T, Sadick G, Tanaka T.
- Journal Title
  
  BMC Complement Altern Med.
  
  Volume: 10 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article]2010
- Author(s)
  Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T, Morihara T, Takeda M.
- Journal Title
  
  Dement Geriatr Cogn Disord 30
  
  Pages: 302-308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010
- Author(s)
  Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 14290-14931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.2010
- Author(s)
  Hashimoto R, Ohi K, Yasuda Y, Fukumoto M, Iwase M, Iike N, Azechi M, Ikezawa K, Takaya M, Takahashi H, Yamamori H, Okochi T, Tanimukai H, Tagami S, Morihara T, Okochi M, Tanaka T, Kudo T, Kazui H, Iwata N, Takeda M.
- Journal Title
  
  Am J Med Genet B Neuropsychiatr Genet.
  
  Volume: 153 Pages: 1459-64
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010
- Author(s)
  Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 14290-14931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010
- Author(s)
  Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 64 Pages: 592-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.2010
- Author(s)
  Hayashi N, Kazui H, Kamino K, Tokunaga H, Takaya M, Yokokoji M, Kimura R, Kito Y, Wada T, Nomura K, Sugiyama H, Yamamoto D, Yoshida T, Currais A, Soriano S, Hamasaki T, Yamamoto M, Yasuda Y, Hashimoto R, Tanimukai H, Tagami S, Okochi M, Tanaka T, Kudo T
- Journal Title
  
  Dement Geriatr Cogn Disord.
  
  Volume: 30 Pages: 302-8
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients2010
- Author(s)
  Okochi, M., Tagami, S., Takeda, M.
- Journal Title
  
  Neurodegenerative Dis 7
  
  Pages: 42-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.2010
- Author(s)
  Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285 Pages: 14920-31
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] Apolipoprotein E and central nervous system disorders : reviews of clinical findings.2010
- Author(s)
  Takeda M, Martinez R, Kudo T, Tanaka T, Okochi M, Tagami S, Morihara T, Hashimoto R, Cacabelos R.
- Journal Title
  
  Psychiatry Clin Neurosci
  
  Volume: 64 Pages: 592-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591284
[Journal Article] The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.2010
- Author(s)
  Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M.
- Journal Title
  
  Psychogeriatrics 10
  
  Pages: 117-123
- NAID
  10029771051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor.2009
- Author(s)
  Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
- Journal Title
  
  Neurodegenerative Dis 6
  
  Pages: 230-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system2009
- Author(s)
  Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
- Journal Title
  
  EMBO Molecular Medicine 1
  
  Pages: 223-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] The 28-amino acid form of an APLP1-derived Ab-like peptide is a surrogate marker for Ab42 production in the central nervous system.2009
- Author(s)
  Yanagida K, Okochi, M., Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
- Journal Title
  
  EMBO Molecular Medicine 1
  
  Pages: 223-235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Takeda, M. Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients2009
- Author(s)
  Okochi, M., Tagami, S.
- Journal Title
  
  Neurodegenerative Dis 7
  
  Pages: 42-45
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor2009
- Author(s)
  Itoh N, Okochi, M., Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M.
- Journal Title
  
  Neurodegenerative Dis 6
  
  Pages: 230-239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Tagami S. Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M.
- Journal Title
  
  Molecular and Cellular Biology. 28
  
  Pages: 165-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Regulation of Notch signaling byd ynamic changes in the precision of S3 cleavage of Notch-1.2008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
- Journal Title
  
  Mol Cell Biol. 28(1)
  
  Pages: 165-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Amyloid-beta 42 generating process may have a biologicalrole in regulation of Notch signaling intensity2008
- Author(s)
  Tagami S., Okochi M., Fukumori A., Takeda M
- Journal Title
  
  Jpn. J. Neuropsychopharmacology 28
  
  Pages: 177-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Okochi, M., Tagami, S., Takeda, M.
- Journal Title
  
  Annual Report of Osaka University Academic Achievement 2007-2008 9
  
  Pages: 94-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Difficulty identifying spinocerebellar ataxia 17 from precedingric symptoms2008
- Author(s)
  Ohi K, Hashimoto R, Sugai F, Yasuda Y, Tagami s, Takamura H, Morihara T, Okochi M, Tanaka T, Kudo T, Sakoda s, Takeda M
- Journal Title
  
  Psychiatry and Clinical Neuroscience 62
  
  Pages: 625-625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Fulminant case of Guillain-Barre syndrome with poor recovenpression after Haemophilus influenzae infection2008
- Author(s)
  Tagami S., Susuki K., Takeda M., Koga M
- Journal Title
  
  Psychiatry and Clinical Neuroscience 62
  
  Pages: 487-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Processes of beta-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/gamma-Secretase.2008
- Author(s)
  Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
- Journal Title
  
  Neurodegener Dis. 5(3-4)
  
  Pages: 160-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Tagami, S, Okochi, M, Yanagida, K, Ikuta, A, Fukumori, A, Matsumoto, N, Ishizuka-Katsura, Y Nakayama, T, Itoh, N, Jiang, J, Nishitomi, K, Kamino, K, Morihara, T, Hashimoto, R, Tanaka, T, Kudo, T, Chiba, S, Takeda, M
- Journal Title
  
  Molecular and Cellular Biology. Jan 28
  
  Pages: 165-176
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid-β peptides from cerebrospinal fluid to peripheral blood2008
- Author(s)
  Jiang, J., Okochi, M., Tagami, S., Nishitomi, K., Yanagida, K., Nakayama, T., Tatsumi, S.-I., Mori, K., Takeda, M
- Journal Title
  
  Psychogeriatrics
  
  Pages: 188-195
- NAID
  10027274800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia2008
- Author(s)
  Takahashi H, Iwase M, Ishii R, 0hi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, like N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M
- Journal Title
  
  Neurosci Res 62
  
  Pages: 187-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.2008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
- Journal Title
  
  Mol Cell Biol. 28(1)
  
  Pages: 165-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid-β peptides from cerebrospinal fluid to peripheral blood2008
- Author(s)
  Jiang, J., Okochi, M., Tagami, S., Nishitomi, K., Yanagida, K., Nakayama, T., Tatsumi, S. -I., Mori, K., Takeda, M.
- Journal Title
  
  Psychogeriatrics 8
  
  Pages: 188-195
- NAID
  10027274800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-12008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M
- Journal Title
  
  Mol Cell Biol 28(1)
  
  Pages: 165-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Amyloid-beta 42 generating process may have a biological re inegulatin of Notch signaling Jpn.2008
- Author(s)
  Tagami S., Okochi M., Fukumori A., Takeda M.
- Journal Title
  
  J.Neuropsychopharmacology 28
  
  Pages: 177-183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Macrophage colony stimulating factor is associated with excretion of amyloid- peptides from cerebrospinal fluid to peripheral blood.2008
- Author(s)
  Jiang J., Okochi M., Tagami S., Nishitomi K., Yanagida K., Nakayama T., Tatsumi K.,Mori K., Takeda M.
- Journal Title
  
  Psychogeriatrics 8
  
  Pages: 188-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Processes of beta-amyloid and intracellular cytoplasmic domain generation by presenilin/gamma-secretase.2008
- Author(s)
  Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M.
- Journal Title
  
  Neurodegenerative Diseases 5
  
  Pages: 160-162
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Macrophage colony stimulating factor is associated with exeretion of amyloid-peptides from cerebrospinal fluid to peripheral blood2008
- Author(s)
  Jiang J., Okochi M., Tagami S., Nishitomi K., Yanagida K., Nakayama T., Tatsumi K., Mori K., Takeda M
- Journal Title
  
  Psychogeriatrics 8
  
  Pages: 188-195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Processes of beta-amyloid and intracellular cytoplasmic domaingeneration by presenili n/gamma-secretase2008
- Author(s)
  Tagami, S, Okochi, M, Fukumori, A, Jiang, J, Yanagida, K, Nakayama, T, Morihara, T, Tanaka, T, Kudo, T, Takeda, M
- Journal Title
  
  Neurodegenerative Diseases 5
  
  Pages: 160-162
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Fulminant case of Guillain-Barre syndrome with poor recovery and depression after Haemophilus influenzae infection.2008
- Author(s)
  Tagami S., Susuki K., Takeda M., Koga M.
- Journal Title
  
  Psychiatry and Clinical Neuroscience 62
  
  Pages: 487-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Processes of beta-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/gamma-Secretase2008
- Author(s)
  Tagami S, Okochi M, Fukumori A, Jiang J, Yanagida K, Nakayama T, Morihara T, Tanaka T, Kudo T, Takeda M
- Journal Title
  
  Neurodegener Dis 5(3-4)
  
  Pages: 160-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M.
- Journal Title
  
  Molecular and Cellular Biology. 28
  
  Pages: 165-176
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.2008
- Author(s)
  Takahashi H, Iwase M, Ishii R, Ohi K, Fukumoto M, Azechi M, Ikezawa K, Kurimoto R, Canuet L, Nakahachi T, Iike N, Tagami S, Morihara T, Okochi M, Tanaka T, Kazui H, Yoshida T, Tanimukai H, Yasuda Y, Kudo T, Hashimoto R, Takeda M.
- Journal Title
  
  Neurosci Res 62
  
  Pages: 187-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591405
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities2007
- Author(s)
  Takeda, M, Okochi, M, Tagami, S, Tanaka, T, Kudo, T
- Journal Title
  
  Int Psychogeriatr 19
  
  Pages: 391-400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions--real problems and future possibilities2007
- Author(s)
  Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T
- Journal Title
  
  Int Psychogeriatr 19(3)
  
  Pages: 391-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interve ntions-real problems and future possibilities.2007
- Author(s)
  Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T.
- Journal Title
  
  Int Psychogeriatr. 19(3)
  
  Pages: 391-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591352
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities.2007
- Author(s)
  Takeda M, Okochi M, Tagami S. Tanaka T, Kudo T.
- Journal Title
  
  Int Psychogeriatr. 19
  
  Pages: 391-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Biological markers as outcome measures for Alzheimer's disease interventions-real problems and future possibilities.2007
- Author(s)
  Takeda M, Okochi M, Tagami S, Tanaka T, Kudo T.
- Journal Title
  
  International Psychogeriatrics 19
  
  Pages: 391-400
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M, Takeda M.
- Journal Title
  
  Psychogeriatrics Dec 6:(SUPPL.2)
- NAID
  10025860692
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease.2006
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M and Takeda M.
- Journal Title
  
  Psychogeriatrics SUPPL.2
- NAID
  10025860692
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 281.12
  
  Pages: 7890-7898
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci Suppl 1
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci. Apr;60
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry. 45(15)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun. 344
  
  Pages: 525-530
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry Apr 18;45(15)
  
  Pages: 4907-4914
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun 344(2)
  
  Pages: 525-530
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct2006
- Author(s)
  Fukumori, A, Okochi, M, Tagami, S, Jiang, J, Itoh, N, Nakayama, T, Yanagida, K, Ishizuka-Katsura Y, Morihara, T, Kamino, K, Tanaka, T, Kudo, T, Tanii, H, Ikuta, A, Haass, C, Takeda, M
- Journal Title
  
  Biochemistry 45(15)
  
  Pages: 4907-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Biological markers for diagnosis of MCI and eurodegenerative dementia2006
- Author(s)
  Takeda M, Kudo T, Tanaka T, Kamino K, Okochi M, Tagami S
- Journal Title
  
  Functional and Moleculart Imaging of Strokeka dn Dementia
  
  Pages: 101-107
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Inhibition ofendocytosis activates alternative degradation pathway of β APP in cultured cells2006
- Author(s)
  Akio Fukumori, Jingwei Jiang, Hisashi Tanii, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, Naohiro Ito, Shinji Tagami, Masayasu Okochi, Masatoshi Takeda
- Journal Title
  
  Psychogeiatrics 6(3)
  
  Pages: 107-113
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Inhibition of endocytosis activates alternative degradation pathway of CAPP in cultured cells2006
- Author(s)
  Fukumori, A, Jiang, J, Tanii, H, Morihara, T, Kamino, K, Tanaka, T, Kudo, T, Itoh, N, Tagami, 5, Okochi, M, Takeda, M
- Journal Title
  
  Psychogeriatrics 6
  
  Pages: 107-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M
- Journal Title
  
  Biochem Biophys Res Commun Jun2:344(2)
  
  Pages: 525-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Secretion of the Notch-1 A β-like peptide 」during Notch signaling2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 28(12)
  
  Pages: 7890-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
- Journal Title
  
  Biochemistry 45 (15)
  
  Pages: 4907-4914
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] 非ステロイド性消炎薬(NSAIDs)のAβ42産生阻幸作用とその応用2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  CURRENT THERAPY Vol.24 No.3
  
  Pages: 33-37
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] セクレターゼ阻害薬2006
- Author(s)
  福森亮雄, 田上真次, 大河内正康, 武田雅俊
- Journal Title
  
  Pharma Medica Vol.24 No.7
  
  Pages: 4-4
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, and Takeda M.
- Journal Title
  
  Biochem Diophys Res Commun 344
  
  Pages: 525-530
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci. 60 Suppl 1
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci 60 Suppl
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Inhibition of endocytosis activates alternative degradation pathway of・APP in cultured cells2006
- Author(s)
  Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, and Takeda M
- Journal Title
  
  Psychogeriatrics Sep 6
  
  Pages: 107-113
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem 24;281(12)
  
  Pages: 7890-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Secretion of the Notch-1 Abeta-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] A β induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006
- Author(s)
  Daisuke Kanayama, Takashi Kudo, Ryo Kimura, Nobuhiko Tabuchi, Akio Fukumori, Takashi Morihara, Shinji Tagami, Hisashi Tanii, Masayasu Okochi, Kojin Kamino, Toshihisa Tanaka, Kazunori Imaizumi, Takeshi Tabira, Masatoshi Takeda
- Journal Title
  
  Psychogeiatrics 6(3)
  
  Pages: 100-106
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry. 18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006
- Author(s)
  Nessa, BN, Tanaka, T, Kamino, K, Sadik, G, Ansar, AB, Kimura, R, Tanii, H, Okochi, M, Morihara, T, Tagami, S, Kudo, T, Takeda, M
- Journal Title
  
  Psychiatry Clin Neurosci 60,1
  
  Pages: 527-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway.2006
- Author(s)
  .Kanayama D, T, Kudo, Kimura R, Tabuchi N, Fukumori A, Morihara T, Tagami S, Tanii H, Okochi M, Kamino K, Tanaka T, Imaizumi K, Tabira T, and Takeda M.
- Journal Title
  
  Psychogeriatrics 6
  
  Pages: 100-106
- NAID
  10019375777
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells.2006
- Author(s)
  Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, Takeda M
- Journal Title
  
  Psychogeriatrics Sep 6
  
  Pages: 107-113
- NAID
  10019375803
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in ρAlzheimer's disease2006
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M and Takeda M.
- Journal Title
  
  Psychogeriatrics Dec 6:
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M.
- Journal Title
  
  J Neurosci Res Sep;84(4)
  
  Pages: 918-925
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 3月予定(In press)
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Presenilin-Dependent Y-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct2006
- Author(s)
  Akio Fukumori, Masayasu Okochi, Shinji Tagami, Jinwei Jiang, Naohiro Itoh, Taisuke Nakayama, Kanta Yanagida, Yoshiko Ishizuka-Katsura, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, et al.
- Journal Title
  
  Biochemistry 45
  
  Pages: 4907-4914
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Inhibition of endocytosis activates alternative degradation pathway of /3 APP in cultured cells.2006
- Author(s)
  Fukumori A, Jiang J ; Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S. Okochi M, Takeda M
- Journal Title
  
  Psychogeriatrics.
  
  Pages: 107-113
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 3月号予定(in press)
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006
- Author(s)
  Nessa, BN, Tanaka, T, Kamino, K, Sadik, G, Ansar, AB, Kimura, R, Tanii, H, Okochi, M, Morihara, T, Tagami, S, Kudo, T, Takeda, M
- Journal Title
  
  PsychiatryClin Neurosci 60 Suppl 1
  
  Pages: 27-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Toll-like receptor 3 mediated ρhyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci. 60 Suppl 1
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Thhyama M, Tabira T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun. 2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, and Takeda M.
- Journal Title
  
  Journal of Neuroscience Research 84
  
  Pages: 918-925
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  BIOCHEMISTRY 45(15)
  
  Pages: 4907-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Altered localization of amyloid precursor protein under endoplasmicreticulum stress2006
- Author(s)
  Kudo, T, Okumura, M, Imaizumi, K, Araki, W, Morihara, T, Tanimukai, H, Kamagata, E, Tabuchi, N, Kimura, R, Kanayama, D, Fukumori, A, Tagami, S, Okochi, M, Kubo, M, Tanii, H, Tohyama, MTabira, T, Takeda, M
- Journal Title
  
  Biochem BiophysReCommun 344(2)
  
  Pages: 525-30
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Effect of valine on the efficiency and precision a cleavage of the Notch-1 transmembrane domain2006
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, and Takeda M
- Journal Title
  
  J Neurosci Res. Sep;84(4)
  
  Pages: 918-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry 45/15
  
  Pages: 4907-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Inhibition of endocytosis activates alternative degradati on pathway of βAPP in cultured cells.2006
- Author(s)
  Fukumori A, Jiang J, Tanii H, Morihara T, Kamino K, Tanaka T, Kudo T, Itoh N, Tagami S, Okochi M, and Takeda M.
- Journal Title
  
  Psychogeriatrics 6
  
  Pages: 107-113
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Altered localization of amyloid precursor protein under endoplasmis reticulum stress2006
- Author(s)
  Kudo, T, Okumura, M, Imaizumi, K, Araki, W, Morihara, T, Tanimukai, H, Kamagata, E, Tabuchi, N, Kimura, R, Kanayama, D, Fukumiri, A, Tagami, S, Okochi, M, Kubo, M, Tanii, H, Tohyama, M, Tabira, T, Takeda, M
- Journal Title
  
  Biochem Diophys Res Commun 344
  
  Pages: 525-530
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] 非ステロイド性消炎薬(NSAIDs)のAβ42産生阻害作用とその応用2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  CURRENT THERAPY 3月号予定(印刷中)
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tauin human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M.
- Journal Title
  
  Psychiatry Clin Neurosci. Apr60 Suppi 1
  
  Pages: 527-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. Epub
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry. Apr18;45(15)
  
  Pages: 4907-4914
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Ab induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006
- Author(s)
  Kanayama, D, T, Kudo, Kimura, R, Tabuchi, N, FukumoriA, Morihara, T, Tagami, S, Tanii, H, Okochi, M, Kamino, K, Tanaka, T, Imaizumi, K, Tabira, T, Takeda, M
- Journal Title
  
  Psychogeriatrics 6
  
  Pages: 100110-100110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Ito N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem 281-12
  
  Pages: 7890-7898
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006
- Author(s)
  Fukumori A, Okochi M.Tagami S.Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  BIOCHEMISTRY in press
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
- Journal Title
  
  Biochemistry 45
  
  Pages: 5351-5358
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.2006
- Author(s)
  Fukumori A, *Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M.
- Journal Title
  
  Biochemistry 18;45(15)
  
  Pages: 4907-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Presenilin-dependent γ-secretase on plasma membrane and endoso mes is functionally distinct2006
- Author(s)
  Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, Takeda M
- Journal Title
  
  Biochemistry 45
  
  Pages: 5351-5358
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] 非ろテロイド性消炎薬(NSAIDs)のA」42産生阻害作用とその応用2006
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  CURRENT THERAPY Vol 24, No.3
  
  Pages: 33-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] セクレターゼ阻害薬2006
- Author(s)
  福森亮雄, 田上真次, 大河内正康, 武田雅俊
- Journal Title
  
  Pharma Medica Vol.24 No.7
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum-associated degradation pathway2006
- Author(s)
  Daisuke Kanayama, Takashi Kudo, Ryo Kimura, Nobuhiko Tabuchi, Akio Fukumori, Takashi Morihara, Shinji Tagami, Hisashi Tanii, Masayasu Okochi, Kojin Kamino, Toshihisa Tanaka, Kazunori Imaizumi, Takeshi Tabira, Masatoshi Takeda
- Journal Title
  
  Psychogeiatrics 6(3)
  
  Pages: 100-106
- NAID
  10019375777
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, Takashima A, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K, Okochi M, Takeda M.
- Journal Title
  
  Psychogeriatrics. Dec6:(SUPPL.2)
- NAID
  10025860692
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain.2006
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S, Okazaki Y, Okochi M, Takeda M
- Journal Title
  
  J Neurosci Res. Sep;84(4)
  
  Pages: 918-925
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease2006
- Author(s)
  Tagami, S, Tsujimoto, Y, Akaike, A, Takashima, A, Hasegawa, M, Ishiguro, K, Shoji, M, Ito, N, Kanemaru, K, Urakami, K, Okochi, M, Takeda, M
- Journal Title
  
  Psychogeriatrics 6 : (SUPPL.2)
- NAID
  10025860692
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Toll-like receptor 3 mediated hyperphosphorylation of tau in human SH-SY5Y neuroblastoma cells.2006
- Author(s)
  Nessa BN, Tanaka T, Kamino K, Sadik G, Ansar AB, Kimura R, Tanii H, Okochi M, Morihara T, Tagami S, Kudo T, Takeda M
- Journal Title
  
  Psychiatry Clin Neurosci. 60 Suppl 1
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Presenilin-Dependent γ-Secretase on Plasma Membrane and Endosomes Is Functionally Distinct2006
- Author(s)
  Akio Fukumori, Masayasu Okochi, Shinji Tagami, Jinwei Jiang, Naohiro Itoh, Taisuke Nakayama, Kanta Yanagida, Yoshiko Ishizuka-Katsura, Takashi Morihara, Kojin Kamino, Toshihisa Tanaka, Takashi Kudo, Hisashi Tanii, Akiko Ikuta, Chistian Haass, Masatoshi Takeda
- Journal Title
  
  Biochemistry 45
  
  Pages: 4907-4914
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591210
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain-2006
- Author(s)
  Tanii, H, Jiang, J, Fukumori, A, Tagami, S, Okazaki, Y, Okochi, M, Takeda, M
- Journal Title
  
  J Neurosci Res 84(4)
  
  Pages: 918-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Secretion of the Notch-1 Aβ-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Chem. 281/12
  
  Pages: 7890-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591135
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun. 344(2)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591287
[Journal Article] Secretion of the Notch-1 Abeta-like peptide during Notch signaling.2006
- Author(s)
  Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
- Journal Title
  
  J Biol Cliem. Mar24;281(12)Epub
  
  Pages: 7890-7898
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Altered localization of amyloid precursor protein under endoplasmic reticulum stress.2006
- Author(s)
  Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, Tohyama M, Tabira T, Takeda M.
- Journal Title
  
  Biochem Biophys Res Commun. Jun 2;344(2)
- Data Source
  KAKENHI-PROJECT-18591285
[Journal Article] Cleavage at S3 by Presenilin/g-secretase has a diversity.2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
- Journal Title
  
  Dementia Japan 19
  
  Pages: 133-133
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] プレセニリン依存性膜内蛋白分解によるNotch-1のS3切断には多様性が存在する。2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
- Journal Title
  
  Dementia Japan 19
  
  Pages: 133-133
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The S3 cleavage site of Notch-1 by presenilin/γ-secretase has a diversity.2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Takeda M.
- Journal Title
  
  日本神経化学雑誌 44
  
  Pages: 204-204
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] γセクレターゼとNotchシグナル2005
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  Molecular Medicine 42
  
  Pages: 790-798
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The physiological meaning that BACE cleaves amyloid beta.2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Kudo T, Takeda M.
- Journal Title
  
  Joint meeting of the 27th annual meeting of JSBP and the 35th annual meeting of JSNP 27
  
  Pages: 206-206
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The S3 cleavage site of Notch-1 by presenilin/γ-secretase has a diversity.2005
- Author(s)
  Tagami S, Okochi M, Fukumori A, Ito N, Jiang J, Ikuta A, Takeda M.
- Journal Title
  
  Bulletin of the Japanese Society for Neurochemistry 44
  
  Pages: 204-204
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The mechanism of intracellular amyloid beta degradation2004
- Author(s)
  Tagami, S., et al.
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9巻
  
  Pages: 97-97
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Aβの毒性発現機構2004
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  Molecular Medicine 41-No.4
  
  Pages: 427-431
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Biochemical separation of γ-cleavage of βAPP on the plasma membrane from that on the intracellular membrane2004
- Author(s)
  Fukumori, A., Okochi, M., Tagami, S., Tanii, H., Kimura, R., Jiang, J., Steiner, H., Haass, C., Kudo, T., Takeda, M.
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9
  
  Pages: 157-157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The mechanism of intracellular amyloid beta degradation2004
- Author(s)
  Tagami, S., Okochi, M., Fukumori, A., Kimura, R., Jiang, J., Takeda, M
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9
  
  Pages: 97-97
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Subcellular localization of γ-cleavage of βAPP.2004
- Author(s)
  Fukumori, A., Okochi, M., Jiang, J., Kimura, R., Tanii, H., Kudo, T., Tagami, S., Takeda, M
- Journal Title
  
  日本神経化学雑誌 47
  
  Pages: 20-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Aβの毒性発現機構2004
- Author(s)
  大河内正康, 田上真次, 武田雅俊
- Journal Title
  
  Molecular Medicine 41.No.4
  
  Pages: 427-431
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Biochemical separation of γ-cleavage of βAPP on the plasma membrane from that on the intracellular membrane2004
- Author(s)
  Fukumori, A., Okochi, M., Tagami, S, Tanii, H., Kimura, R., Jiang, J., Steiner, H., Haass, C., Kudo, T., Takeda, M.
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9巻
  
  Pages: 157-157
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] The mechanism of intracellular amyloid beta degradation2004
- Author(s)
  Tagami, S., Okochi, M., Fukumori, A., Kimura, R., Jiang, J., Takeda, M
- Journal Title
  
  9th International Conference on Alzheimer's Disease and Related Disorders Abstract Book 9巻
  
  Pages: 97-97
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591132
[Journal Article] Involvement of apoptosis and cholinergic dysfunction in Alzheimer's disease
- Author(s)
  Tagami S, Tsujimoto Y, Akaike A, TakashimaA, Hasegawa M, Ishiguro K, Shoji M, Ito N, Kanemaru K, Urakami K Okochi M Takeda M.
- Journal Title
  
  Psychogeriatrics. 6
- NAID
  10025860692
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Inhibition of Aβ42 production by NSAIDS
- Author(s)
  Okochi M, Tagami S, Takeda M
- Journal Title
  
  CURRENT THERAPY 24(3)
  
  Pages: 33-37
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Biological markers for diagnosis of MCI and eurodegenerative dementia
- Author(s)
  Takeda M, Kudo T, TanakaT, Karnino K, Okochi M, Tagami S
- Journal Title
  
  Functional and Moleculart Imaging of Strokeka dn Dementia
  
  Pages: 101-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Journal Article] Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain
- Author(s)
  Tanii H, Jiang J, Fukumori A, Tagami S. Okazaki Y, Okochi M, Takeda M
- Journal Title
  
  J Neurosci Res. 84(4)
  
  Pages: 918-25
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390318
[Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010
- Inventor(s)
  大河内正康、田上真次、武田雅俊、西冨晃平
- Industrial Property Rights Holder
  大河内正康、田上真次、武田雅俊、西冨晃平
- Filing Date
  2010-10-18
- Overseas
- Data Source
  KAKENHI-PROJECT-22591284
[Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010
- Inventor(s)
  大河内正康、田上真次、武田雅俊、西冨晃平
- Industrial Property Rights Holder
  大河内正康、田上真次、武田雅俊、西冨晃平
- Filing Date
  2010-10-18
- Overseas
- Data Source
  KAKENHI-PROJECT-20591405
[Patent] プレセニリンγセクレターゼによるアルツハイマー病アミロイドの分解アッセイ法2010
- Inventor(s)
  大河内正康, 田上真次, 武田雅俊, 西冨晃平
- Industrial Property Rights Holder
  大河内正康, 田上真次, 武田雅俊, 西冨晃平
- Filing Date
  2010-10-18
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 在宅医療における高齢者の不眠や不安、うつなどの精神症状に効果が期待できる漢方薬について2023
- Author(s)
  田上　真次
- Organizer
  第６５回日本老年医学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07559
[Presentation] Disease Modifying therapy of Alzheimer’s disease in the near future － from the aspect of psychological frailty－2016
- Author(s)
  Shinji Tagami
- Organizer
  The 18th International Congress of Oriental Medicine 2016
- Place of Presentation
  Okinawa Convention Center Room B1
- Year and Date
  2016-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] A brain-derived Aβ42 surrogate marker in peripheral blood2016
- Author(s)
  Shinji Tagami, Kanta Yanagida, Takeshi Tomonaga, Takeshi Ikeuchi, Masaaki Waragai, Masatoshi Takeda, Manabu Ikeda, Masayasu Okochi
- Organizer
  Neuroscience meeting 2016
- Place of Presentation
  San Diego USA
- Year and Date
  2016-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] Development of Abeta42 surrogate marker in peripheral blood2015
- Author(s)
  Shinji Tagami Shozo Sano Kanta Yanagida Takashi Kodama Naoki Mizuta Takeshi Tomonaga Masatoshi Takeda Masayasu Okochi
- Organizer
  12th World Congress Of Biological Psychiatry
- Place of Presentation
  Greece, Athens
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] 家族性アルツハイマー病の脳内でAβ４２産生は亢進しているか？2015
- Author(s)
  田上　真次　柳田　寛太　児玉　高志　新井　哲明　池内　健　武田　雅俊　大河内　正康
- Organizer
  第34回　日本認知症学会　学術総会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] ヒト血漿中に存在するAβペプチドのサロゲートマーカーAPL1βのLC-MS/MSによる測定2015
- Author(s)
  児玉高志、大河内正康、田上真次、柳田寛太、森原剛史、田中稔久、工藤喬、朝長毅、武田雅俊
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーション青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-25461766
[Presentation] CRISP/CAS9法によるPresenilin1/2ダブルノックアウト細胞の作製2015
- Author(s)
  柳田　寛太　田上　真次　　児玉　高志　岡本　徹　松浦　善治　武田　雅俊　大河内　正康
- Organizer
  第34回　日本認知症学会　学術総会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] ヒト血漿中に存在するAβペプチドのサロゲートマーカーAPL1βのLC/MS/MSによる測定2015
- Author(s)
  児玉　高志　大河内　正康　田上　真次　柳田　寛太　森原　剛史　　田中　稔久　朝長　毅　工藤　喬　武田　雅俊
- Organizer
  第34回　日本認知症学会　学術総会
- Place of Presentation
  リンクステーションホール青森
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] アルツハイマー病診断・予防・治療の今後の展望について ―精神心理的フレイルの側面から―2015
- Author(s)
  田上　真次
- Organizer
  第４回先進漢方治療研究会
- Place of Presentation
  梅田スカイビル　タワーウエスト36階
- Year and Date
  2015-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] アミロイドベータ産生機構解析のための細胞内ペプチドの測定2014
- Author(s)
  児玉高志、大河内正康、田上真次、柳田寛太、高見真子、井原康夫、武田雅俊
- Organizer
  第25回日本老年医学会近畿地方会
- Place of Presentation
  和歌山県立医科大学
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25461766
[Presentation] CSF APL1β28 is a possible surrogate marker for Aβ42 production in human brains2013
- Author(s)
  Naoki Mizuta, Masayasu Okochi, Shinji Tagami,Kanta Yanagida, Takashi Kodama,Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
- Organizer
  Neuro2013
- Place of Presentation
  Kyoto
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Identification and quantitative analysis of short peptides derived from amyloid-beta peptides in living cell2013
- Author(s)
  Kodama T.S., Okochi M., Tagami S., Yanagida K., Mizuta N., Tanaka T., Morihara T., Kudo T., Takami M., Ihara Y., Takeda M.
- Organizer
  IPA's 16th International Congress
- Place of Presentation
  Seoul Korea, COEX
- Year and Date
  2013-10-02
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Elucidation of the mechanism underlying the alteration of Aβ42 ratio by g-secretase modulators2013
- Author(s)
  Tagami S, Okochi M, Takeda M
- Organizer
  Neuroscience 2013 Nanosymposium
- Place of Presentation
  San Diego, California
- Year and Date
  2013-11-11
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Identification of APLP2-derived Ab-like peptides from human Cerebrospinal fluid2013
- Author(s)
  柳田寛太、大河内正康、田上真次、児玉高志、武田雅俊
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-06-27
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Regulation of presenilin/gamma-secretase function; towards intervention of Alzheimer disease in future2013
- Author(s)
  Tagami S, Okochi M, Takeda M
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto, Japan (Symposium)
- Year and Date
  2013-06-26
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Degradation of extracellular Aβ42/43 in human brain and cultured cells2013
- Author(s)
  Naoki Mizuta, Masayasu Okochi, Shinji Tagami, Kanta Yanagida, Takashi Kodama, Mako Takami, Yasuo Ihara, Daisuke Kanayama, Takashi Morihara, Takashi Kudo, Toshihisa Tanaka, Masatoshi Takeda
- Organizer
  CTAD2013
- Place of Presentation
  San Diego
- Year and Date
  2013-11-14
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Regulation of presenilin/gamma-secretase function; towards intervention of Alzheimer disease in future2013
- Author(s)
  Tagami S, Okochi M, Takeda M.
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  京都国際会議場　京都
- Invited
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Elucidation of the mechanism underlying the alteration of Aβ42 ratio by g-secretase modulators.2013
- Author(s)
  Tagami S, Okochi M, Takeda M.
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, California(USA)
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Identification and quantitative analysis of APL1ß peptides in human cerebrospinal fluid (CSF)2013
- Author(s)
  Takashi. S. Kodama, Masayasu Okochi, Sinji Tagami, Kanta Yanagida, Naoki Mizuta, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-06-27
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] APL1β28, a new candidate biomarker for Alzheimer disease2013
- Author(s)
  Naoki Mizuta, Masayasu Okochi, Shinji Tagami, Kanta Yanagida, Takashi Kodama, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-06-24
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Determination of APL1ß Peptide Concentration in Cerebrospinal Fluid (CSF) by ELISA2013
- Author(s)
  Takashi. S. Kodama, Masayasu Okochi, Sinji Tagami, Kanta Yanagida, Naoki Mizuta, Toshihisa Tanaka, Takashi Morihara, Takashi Kudo, Masatoshi Takeda
- Organizer
  Neuro2013
- Place of Presentation
  Kyoto, International Conference Center
- Year and Date
  2013-06-21
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP22012
- Author(s)
  Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver Convention & Exhibition Centre, Vancouver Canada
- Year and Date
  2012-07-18
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際2012
- Author(s)
  大河内正康, 田上真次, 柳田寛太, 児玉高志, 武田雅俊
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-28
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際2012
- Author(s)
  大河内正康田上真次柳田寛太児玉高志武田雅俊
- Organizer
  第31回日本認知症学会学術集会トピックス徹底討論「抗 Ab 療法の最新現状と徹底討論」
- Place of Presentation
  つくば国際会議場、第4 会場 2F 中ホール
- Year and Date
  2012-10-28
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] ラフトのγセクレターゼによるAPP膜内段階的切断機構2012
- Author(s)
  松村展敬, 高見真子, 田上真次, 大河内正康, 井原康夫, 森島真帆
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] APL2βの産生メカニズムの解析(2)APLP2はプレセニリン1と2で異なる切断を受ける2012
- Author(s)
  柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] ヒト脳脊髄液中APL1βペプチドの高感度定量2012
- Author(s)
  児玉高志, 大河内正康, 田上真次, 柳田寛太, 森原剛史, 田中稔久, 工藤喬, 朝長毅, 武田雅俊
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] APL2βの産生メカニズムの解析(1)APLP2はプレセニリン1と2で異なる切断を受ける2012
- Author(s)
  柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Chracterization of brain APL2β, an Aβ-like peptide produced from APLP22012
- Author(s)
  Masayasu Okochi, Kanta Yanagida, Shinji Tagami, Takashi Kodama, Shozo Sano,Takeshi Tomonaga, Takaomi C.Saido, Masatoshi Takeda
- Organizer
  Alzheimer's Association International Conference 2012
- Place of Presentation
  Vancouver Convention & Exhibition Centre
- Year and Date
  2012-06-20
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] アルツハイマー病発症前診断バイオマーカーの開発脳プロ課題 F ・アミロイドβ42 産生の上流機構の解析(武田班)2012
- Author(s)
  大河内正康田上真次朝長毅武田雅俊
- Organizer
  第34回日本生物学的精神医学会
- Place of Presentation
  会場:E 会場(神戸国際会議場502)
- Year and Date
  2012-09-30
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] "βAPPファミリー蛋白は脳内では主にBACEによってsheddingを受けるが培養細胞に過剰発現させるとα－セクレターゼによる切断が増加する2011
- Author(s)
  柳田　寛太　大河内　正康　田上　真次　児玉　高志　森原　剛史　田中　稔久　工藤　喬　武田　雅俊
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] "Abeta蓄積修飾遺伝子KLC1 splicing variantの同定（１） APPTgマウスを用いた網羅的解析2011
- Author(s)
  林　紀行　横小路　美貴子　森原　剛史　田上　真次　大河内　正康　田中　稔久　工藤　喬　武田　雅俊
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Immuno-SRM/MRMを用いた新規アルツハイマー病血漿マーカーペプチドAPL1βの絶対定量法の確立と臨床応用2011
- Author(s)
  渡邊史生, 田上真次, 佐野聖, 三熊谷久美子, 常見雅彦, 大河内正康, 朝長毅
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Comparison of pretreatment methods for SISCAPA-SRM quantitation of Alzheimer disease biomaker peptide APL1beta in plasma2011
- Author(s)
  Shozo Sano, Shinji Tagami, Masayasu Okochi, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Yoshio Kodera and Takeshi Tomonaga
- Organizer
  日本ヒトプロテオーム機構第9回大会
- Place of Presentation
  新潟市朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Absolute quantitation of plasma biomarker peptides for Alzheimer disease at pM level using SRM coupled with stable isotope standards and capture by anti-peptide antibodies2011
- Author(s)
  Shio Watanabe, Shinji Tagami, Shozo Sano, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Masayasu Okochi and Takeshi Tomonaga
- Organizer
  日本ヒトプロテオーム機構第9回大会
- Place of Presentation
  新潟市朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] BACEとγセクレターゼによって産生される脳内Abeta様ペプチドを末梢血中で検出・同定する2011
- Author(s)
  田上真次, 大河内正康, 柳田寛太, 児玉高志, 池内健, 佐野聖, 三渡邊史, 生数井裕光, 森原剛史, 谷向仁, 田中稔久, 工藤喬, 朝長毅, 武田雅俊
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Decrease in major amyloid beta species may trigger amyloidogenesis in vivo2011
- Author(s)
  Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Hitoshi Tanimukai, Hiroaki Kazui, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda
- Organizer
  10th World Congress of Biological Psychiatry, Prague
- Place of Presentation
  Czech Republic
- Year and Date
  2011-05-30
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] βAPPファミリー蛋白は脳内では主にBACEによってsheddingを受けるが培養細胞に過剰発現させるとα-セクレターゼによる切断が増加する2011
- Author(s)
  柳田寛太, 大河内正康, 田上真次, 児玉高志, 森原剛史, 田中稔久, 工藤喬, 武田雅俊
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  タワーホール船堀
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Decrease in major amyloid beta species may trigger amyloidogenesis in vivo.2011
- Author(s)
  Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Hitoshi Tanimukai, Hiroaki Kazui, Toshihisa Tanaka, Takashi Kudo, Masatoshi Takeda
- Organizer
  10th World Congress of Biological Psychiatry
- Place of Presentation
  Prague, Czech Republic
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Comparison of pretreatment methods for SISCAPA-SRM quantitation of Alzheimer disease biomaker peptide APL1beta in plasma.2011
- Author(s)
  Shozo Sano, Shinji Tagami, Masayasu Okochi, Kumiko Yoshizawa-Kumagaye, Masahiko Tsunemi, Yoshio Kodera and Takeshi Tomonaga
- Organizer
  日本ヒトプロテオーム機構第9回大会
- Place of Presentation
  新潟市朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Abeta全体を産生する仕組みはアルツハイマー病で加速されているか?-患者CSFを用いた解析2010
- Author(s)
  大河内正康, 田上真次, 柳田寛太, 池内健, 秋山治彦, 徳田隆彦, 武田雅俊
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋市ウインク愛知
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta 28について2010
- Author(s)
  田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
- Organizer
  日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  東京ベイホテル東急
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients.2010
- Author(s)
  Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンボンションセンター
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Levels of the surrogate marker for Abeta42(i.e., APL1beta)in CSF of sporadic Alzheimer disease patients increase before the onset of its clinical symptoms2010
- Author(s)
  Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama T, Nishitomi K, Jiang J, Mori K, Tatsumi S, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析 amyloid beta42のサロゲートマーカー、APL1beta28について2010
- Author(s)
  田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
- Organizer
  日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  東京ベイホテル東急
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients2010
- Author(s)
  Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] Determination of Amino acid sequences of several thousand peptides in human cerebrospinal fluid2010
- Author(s)
  Kodama S, Okochi M, Tagami S, Yanagida K, Nakayama T, Tatsumi S, Mori K, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease2010
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takeda M
- Organizer
  Alzheimer's Association International Conference o Alzheimer's Disease 2010
- Place of Presentation
  Honolulu Hawaii U.S.A
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Analysis of CSF of patients suffering from PS1-mutated familial AD indicates that the level of Abeta42 generation does not increase in brain of these patients2010
- Author(s)
  Tagami S, Okochi M, Yanagida K, Kodama T, Takeda M
- Organizer
  第53回日本神経化学会(神戸)大会Neuro2010
- Place of Presentation
  神戸コンベンションセンター
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] The Ratio of Csf Apl1beta28, a Surrogate Marker for Abeta42, Increases Before Onset of Sporadic Alzheimer'S Disease2010
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takeda M
- Organizer
  Alzheimer's Association International Conference o Alzheimer's Disease 2010
- Place of Presentation
  Honolulu Hawaii U.S.A
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22591284
[Presentation] The Rato of Cs Apl1eta28, a Surrogate Marker for Abeta42, Increases Beore Onset of Sporadic Alzheimer'S Disease, Alzheimer's Assoiation.2010
- Author(s)
  Okochi M, Tagami S, Yanagida K, Takeda M.
- Organizer
  Internional Conference on Alzheimer's Disease 2010
- Place of Presentation
  Honolulu Hawaii U.S.A Tagami
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 末梢血中のamyloid beta42のサロゲートマーカー開発について2010
- Author(s)
  田上真次, 大河内正康, 児玉高志, 柳田寛太, 佐野聖三, 朝長毅, 武田雅俊
- Organizer
  第29回日本認知症学会学術集会
- Place of Presentation
  名古屋市ウインク愛知
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] アルツハイマー病の発症予期診断バイオマーカー開発を目的とした脳脊髄液中のペプチド解析amyloid beta42のサロゲートマーカー2010
- Author(s)
  田上真次, 柳田寛太, 児玉高志, 佐野聖三, 朝長毅, 武田雅俊, 大河内正康
- Organizer
  APL1beta 28について日本ヒトプロテオーム機構第8回大会
- Place of Presentation
  東京ボイホテル東急
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Overproduction of Aβ42 may not occur even in brain of PS1 familial AD patients in which tremendous amounts of Aβ42 accumulate in cotton wool plaques.2009
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Organizer
  第28回日本認知症学会
- Place of Presentation
  仙台、東北大学百周年記念会館
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 病的に低下した Notch シグナルを是正する新たな方法の開発について2009
- Author(s)
  田上真次, 大河内正康
- Organizer
  第4回 Notch 研究会
- Place of Presentation
  国立遺伝学研究所講堂
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 病的に低下したNotchシグナルを是正する新たな方法の開発について2009
- Author(s)
  田上真次, 大河内正康
- Organizer
  第4回Notch研究会
- Place of Presentation
  国立遺伝学研究所講堂
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 家族性アルツハイマー病の発症機序において、脳内アミロイドβ42の産生増大は本当に起こっているか?2009
- Author(s)
  田上真次, 大河内正康, 柳田寛太, 中山泰亮, 児玉高志, 辰巳真一, 森康治, 武田雅俊
- Organizer
  第16回未病システム学会総会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Analysis of an Aβ-like peptide in human CSF to address how the cleavage precision of presenilin/γ-secretase is altered in PS1 familial AD patients2009
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Organizer
  International Conference on Alzheimer's Disease (ICAD)
- Place of Presentation
  Messe Wien Exhibition and Congress Center Vienna, Austria
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Overproduction of Aβ42 may not occur even in brain of PS1 familial AD patients in which tremendous amounts of Aβ42 accumulate in cotton wool plaques. -Aβ40 is "good" and Aβ42 is "bad"?2009
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Organizer
  第28回日本認知症学会
- Place of Presentation
  仙台, 東北大学百周年記念会館
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Relation between preseniln/γ -secretase modulators and Notch signaling intensity.2008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi S, Jiang J, Mori KSakaguchi G, Kato A, Hasegawa H, Nishimra M, Takeda M.
- Organizer
  第27回日本認知症学会
- Place of Presentation
  群馬県前橋テルサ
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] 「アルツハイマー病の病原性物質であるAβ42」を産生する仕組みには「細胞の分化に必須のNotchシグナル強度」を調節する生理作用がある-Aβ42産生抑制薬の開発時に予想される問題点とその解決法の模索2008
- Author(s)
  田上真次大河内正康武田雅俊
- Organizer
  第51回日本神経化学大会シンポジウム8アルツハイマー病の神経化学
- Place of Presentation
  富山国際会議場
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] アルツハイマー病の病原性物質であるAβ42」を産生する仕組みには「細胞の分化に必須のNotchシグナル強度」を調節する生理作用がある2008
- Author(s)
  田上真次, 大河内正康, 武田雅俊
- Organizer
  第51回日本神経化学大会シンポジウム8アルツハイマー病の神経化学
- Place of Presentation
  富山国際会議場
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Changes in the cleavage precision of presenilin/r-secretase regulate Notch signaling intensity2008
- Author(s)
  Tagami, s., Okochi, M., Takeda, M
- Organizer
  The llth International Conference on Alzheimer's disease and Related Disorders
- Place of Presentation
  McCormick Place, Chicago, USA
- Year and Date
  2008-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Changes in the cleavage preision of presenilin/γ-secretase regulate Notch signalingtensity.2008
- Author(s)
  Tagami, S., Okochi, M., Takeda, M.
- Organizer
  The 11th International Conference on Alzheimer's disease and Related Disorders
- Place of Presentation
  McCormick Place, Chicago, USA
- Year and Date
  2008-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Notch signaling can be up-regulated through modification ofpresenilin/r-secretase-mediated S3 cleavage2008
- Author(s)
  Tagami, s., Okochi, M., Takeda, M
- Organizer
  The 31th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  東京国際会議場
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Notch signaling can be up-regulated through modification of presenilin/γ-secretase-mediated S3 cleavage.2008
- Author(s)
  Tagami, S., Okochi, M., Takeda, M.
- Organizer
  The 31th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  東京国際会議場
- Year and Date
  2008-07-30
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Relation between presenilin/r-secretase modulators and Notchsignaling intensity2008
- Author(s)
  Tagami s, Okochi M, Yanagida K, Nakayama T, Kodama T, Tatsumi s, Jiang J, Mori KSakaguchi G, KatoA, Hasegawa H, NishimuraM, Takeda M
- Organizer
  第27回日本認知症学会
- Place of Presentation
  群馬県前橋テルサ
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] プレセニリンフセクレターゼ修飾薬の生理活性について2008
- Author(s)
  田上真次大河内正康武田雅俊
- Organizer
  第51回日本神経化学大会
- Place of Presentation
  富山国際会議場
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-20591405
[Presentation] Changes in a precision of S3 cleavage by presenilin/γ-secretase regulate Notch signaling.2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  大阪国際会議場
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Changes in a precision of S3 cleavage by presenilin/γ-secretaseregulate Notch signaling.2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  大阪国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Changes in a precision of S3 cleavage by presenilin/y-secretase regulate Notch signaling2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  Osaka International Congress Hall
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-12007
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  37th Neoroscience Meeting
- Place of Presentation
  San Diego Convention Center Room 28E
- Year and Date
  2007-11-05
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by a novel S3 cleavage diversity2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  29th JSBP
- Place of Presentation
  Sapporo convention center
- Year and Date
  2007-07-12
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Enhancement ofAbeta degradation by BACE12007
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  Osaka International Congress Hall
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Dynamic regulation of Notch signaling by presenilin/y-secretase2007
- Author(s)
  Tagami, S., Okochi, M., Takeda, M
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  Osaka International Congress Hall
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by dynamic changes in the precision in S3 cleavage of Notch-1.2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
- Organizer
  37th Neoroscience Meeting
- Place of Presentation
  San Diego Convention Center Room 28E
- Year and Date
  2007-11-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Dynamic regulation of Notch signaling by presenilin/γ-secretase2007
- Author(s)
  Tagami, S., Okochi, M., and Takeda M.
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  大阪国際会議場
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by a novel S3 cleavage diversity2007
- Author(s)
  田上真次大河内正康柳田寛太生田亜希子福森亮雄森康治姜経緯西冨晃平小栗崇史中山泰亮武田雅俊
- Organizer
  第29回日本生物学的精神医学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2007-07-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Enhancement of Abeta degradation by BACE1.2007
- Author(s)
  Tagami, S., Okochi, M., Nakayama T., Jiang J., Nishitomi K., Mori K., Fukumori A., Yanagida K., and Takeda, M.
- Organizer
  The 13th Congress of International Psychogeriatric Association
- Place of Presentation
  大阪国際会議場
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by presenilin/y-secretase2006
- Author(s)
  Tagami, S., Okochi, M., Fukumori, A., Takeda, M
- Organizer
  49th JNC
- Place of Presentation
  Nagoya convention center
- Year and Date
  2006-09-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Effects of multiple factors including y-secretase modifiers on the precision of Presenilin-dependent intramambranous proteolysis2006
- Author(s)
  Tagami, S., Okochi, M., Nakayama, T., Jiang, J., Nishitomi, K., Mori, K., Fukumori, A., Yanagida, K., Takeda, M
- Organizer
  25th JSDR
- Place of Presentation
  Nagoya convention center
- Year and Date
  2006-10-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Comparison of S3 cleavage of Notch-1 with ε-cleavage of βAPP by presenilin/γ-secretase2006
- Author(s)
  Shinji Tagami, Masayasu Okochi, Akio Fukumori, and Masatoshi Takeda
- Organizer
  The 10th International Conference on Alzheimer's disease and Related Disorders
- Place of Presentation
  IFEMA Feria de Madrid, Spain
- Year and Date
  2006-07-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Effects of multiple factors including γ-secretase modifiers on the precision of Presenilin-dependent intramambranous proteolysis.2006
- Author(s)
  田上真次大河内正康福森亮雄姜経緯森康治中山泰亮生田亜希子桂芳子小栗崇史西冨晃平伊藤尚弘柳田寛太武田雅俊
- Organizer
  第25回日本認知症学会大会
- Place of Presentation
  広島国際会議場
- Year and Date
  2006-10-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Comparison of S3 cleavage of Notch-1 withy-cleavage of BAPP by presenilin/y-secretase2006
- Author(s)
  Tagami, S., Okochi, M., Fukumori, A., Takeda, M
- Organizer
  The 10th International Conference on Alzheimer's disease and Related Disorders
- Place of Presentation
  IFEMA Feria de Madrid, Spain
- Year and Date
  2006-07-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] Regulation of Notch signaling by presenilin/□-secretase2006
- Author(s)
  田上真次大河内正康福森亮雄姜経緯森康治中山泰亮生田亜希子桂芳子小栗崇史西冨晃平伊藤尚弘柳田寛太武田雅俊
- Organizer
  第49回日本神経化学会大会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2006-09-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591285
[Presentation] APL2βの産生メカニズムの解析（１）APLP2はプレセニリン１と２で異なる切断を受ける
- Author(s)
  柳田　寛太　大河内　正康　田上　真次　児玉　高志　森原　剛史　田中　稔久　工藤　喬　武田　雅俊
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] Identification and quantitative analysis of short peptides derived from amyloid-beta peptides in living cell
- Author(s)
  Kodama T.S., Okochi M., Tagami S., Yanagida K., Mizuta N., Tanaka T., Morihara T., Kudo T., Takami M., Ihara Y., Takeda M.
- Organizer
  IPA’s 16th International Congress
- Place of Presentation
  COEX( Seoul Korea)
- Data Source
  KAKENHI-PROJECT-25461766
[Presentation] 細胞内に存在するAbeta由来のオリゴペプチドのLC-MS/MSによる測定
- Author(s)
  児玉高志、大河内正康、田上真次、柳田寛太、水田直樹、高見真子、井原康夫、武田雅俊
- Organizer
  第33回　日本認知症学会学術集会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-25461766
[Presentation] γセクレターゼの阻害と促進
- Author(s)
  大河内　正康　田上　真次　柳田　寛太武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] γセクレターゼ修飾薬のアルツハイマー病予防薬としての理論と実際
- Author(s)
  大河内　正康　田上　真次　柳田　寛太　児玉　高志　武田　雅俊
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] APL2βの産生メカニズムの解析（２）APLP2はプレセニリン１と２で異なる切断を受ける
- Author(s)
  柳田　寛太　大河内　正康　田上　真次　児玉　高志　森原　剛史　田中　稔久　工藤　喬　武田　雅俊
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] 末梢血中のAβ42サロゲートマーカー、APL1b28の開発状況について
- Author(s)
  田上　真次　大河内　正康　佐野　聖三　柳田　寛太児玉　高志　水田　直樹　　朝長　毅　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] 脳脊髄液中のAβ分解産物の同定
- Author(s)
  水田　直樹　大河内　正康　田上　真次　柳田　寛太　児玉　高志　　佐野　聖三　朝長　毅森原　剛史　田中　稔久　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] iPS由来ヒト大脳皮質神経細胞のAβ産生に関連する性質
- Author(s)
  大河内　正康　柳田　寛太大山　洋　児玉　高志　高見　真子　井原　康夫阪口　岳　田上　真次　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] ヒト脳脊髄液中APL1βペプチドの高感度定量
- Author(s)
  児玉　高志　大河内　正康　田上　真次　柳田　寛太　森原　剛史　田中　稔久　工藤　喬　朝長　毅　武田　雅俊
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] ラフトのγセクレターゼによるAPP膜内段階的切断機構
- Author(s)
  松村　展敬　高見　真子　田上　真次　大河内　正康　井原　康夫　森島　真帆
- Organizer
  第３１回日本認知症学会学術集会
- Place of Presentation
  つくば国際会議場
- Data Source
  KAKENHI-PROJECT-23591703
[Presentation] 細胞内に存在するAβ由来のオリゴペプチドのLC-MS/MSによる測定
- Author(s)
  児玉　高志　大河内　正康　田上　真次　柳田　寛太　水田　直樹　　高見　真子　井原　康夫　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] γ-secretase modulatorはAD由来のiPS細胞にも効果がある
- Author(s)
  柳田　寛太　大山　洋　大河内　正康　田上　真次　児玉　高志　水田　直樹　　阪口　岳　武田　雅俊
- Organizer
  第33回　日本認知症学会　学術総会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-29 – 2014-12-01
- Data Source
  KAKENHI-PROJECT-26461746
[Presentation] Levels of an amyloid beta42 surrogate marker in CSF of familial Alzheimer disease patients
- Author(s)
  Shinji Tagami, Masayasu Okochi, Kanta Yanagida, Takashi Kodama, Takeshi Ikeuchi Takashi Morihara, Tetsuaki Arai, Toshihisa Tanaka, Masatoshi Takeda
- Organizer
  XVI World Congress of Psychiatr
- Place of Presentation
  Madrid, Spain
- Year and Date
  2014-09-14 – 2014-09-18
- Data Source
  KAKENHI-PROJECT-26461746

1. MASAYASU Okochi (90335357)

# of Collaborated Projects: 16 results

# of Collaborated Products: 272 results
2. TAKEDA Masatoshi (00179649)

# of Collaborated Projects: 10 results

# of Collaborated Products: 246 results
3. YANAGIDA Kanta (70467596)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
4. KUDO Takashi (10273632)

# of Collaborated Projects: 4 results

# of Collaborated Products: 31 results
5. MORIHARA Takashi (90403196)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
6. TANAKA Toshihisa (10294068)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
7. KODAMA Takashi (30512131)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 紙野晃人 (40307955)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
9. 吉山顕次 (20426498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 森康治 (40775318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 池田学 (60284395)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 菅原裕子 (90610692)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TAKEDA Junko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. HATAZAWA Jun

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. KAZUI Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 池田和博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 鈴木利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tagami Shinji 田上 真次

田上 真次 タガミ シンジ

TAGAMI Shinji 田上 真次

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Development of Alzheimer disease biomarkerPrincipal Investigator

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Mechanism of presenilin/gamma secretase to produce amyloid betaPrincipal Investigator

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Analysis of presenilin gamma-secretase function on Abeta and NICD generationPrincipal Investigator

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Development of methods to promote degradation of amyloid betaPrincipal Investigator

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Characterization of BACE-mediated proteolysis including amyloid-betaPrincipal Investigator

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Tagami Shinji 田上真次

田上真次タガミシンジ

TAGAMI Shinji 田上真次

[Book] 神経内科第72巻特別増刊号認知症診断マニュアル総論的事項-アルツハイマー病の病理過程の理解と治療薬開発 (Aβカスケード、神経栄養因子、神経伝達物質)2010