TOMA-FUKAI SACHIKO 深井祥子 (藤間祥子)

… Alternative Names

Toma-Fukai Sachiko 深井祥子

藤間祥子

TOMA Sachiko 藤間祥子

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Researcher Number	40363535
Other IDs
Affiliation (Current)	2025: 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 奈良先端科学技術大学院大学, 先端科学技術研究科, 准教授 2015: 東京大学, 大学院薬学系研究科, 助教 2007 – 2010: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Assistant Professor 2008: The University of Tokyo, 大学院薬学研究科, 助教 2007: 東京大学, 大学院・薬学系研究科, 助手 2006: 東京大学, 大学院薬学系研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Structural biochemistry / Physical pharmacy Except Principal Investigator Physical pharmacy / Biological Sciences
Keywords	Principal Investigator X線結晶構造解析 / 結晶構造解析 / 構造生物学 / クライオ電子顕微鏡解析 / 核輸送 / 創薬 / 翻訳後修飾酵素 / ポリユビキチン化反応 / Ｘ線結晶構造解析 / 構造生物 … More / ユビキチンリガーゼ / ユビキチンE3リガーゼ / ユビキチン / X線結晶解析 / 自然免疫 … More Except Principal Investigator X線結晶構造解析 / Toll-Like-Receptor / MD-2 / 構造生物学 / p53 / Nucleomethylin / Mybbpla / Ｘ線小角散乱 / Ｘ線結晶解析 / Smad / ビタミンDレセプター / X線小角散乱 / Ｘ線結晶構造解析 / 核内受容体 / Roquin / X線結晶解析 / アルギニンメチル化酵素 / SAM / 翻訳後修飾 / PRMT / アルギニンメチル化 / Structure Biology / X-Ray Crystal Structure / Lipopolysaccharide / Endotoxin / Septis / Innate Immunity / X線結晶構造析 / Toll-Like-Recetor / リポ多糖 / エンドトキシン / 敗血症 / Toll-Like-Peceptor / 自然免疫 / フォールディング / Hsp40 / 変性 / 巻き戻し / 結晶化 / シャペロン / 熱ショック蛋白質 Less

Transportin-1が担う非古典的核輸送機構解明に向けた構造生物研究Principal Investigator
- Principal Investigator
  
  深井祥子 (藤間祥子)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Nara Institute of Science and Technology
Structural study of the PCAF-HD domain of GCN5 to reveal signaling in hepatic glucogenesisPrincipal Investigator
- Principal Investigator
  
  Toma-Fukai Sachiko
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Nara Institute of Science and Technology
Structural analysis of the transcription environment factors that engage in crosstalk with metabolic pathways
- Principal Investigator
  
  Shimizu Toshiyuki
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structure basis for ligand recognition and singnal inducing mechanism involved in TLR4・MD-2 complex.Principal Investigator
- Principal Investigator
  
  TOMA Sachiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
Structural basis for ligand recognition of TLR4Principal Investigator
- Principal Investigator
  
  TOMA Sachiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
ヒト熱ショック蛋白質Hsp40コシャペロンの構造生物学研究
- Principal Investigator
  
  SATO Yoshinori
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo
X-Ray Crystal Structure Analyses of Inante Immunological TLR-Related Receptor Proteins for Sepsis Treatments
- Principal Investigator
  
  SATO Yoshinori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2016

All Journal Article Presentation

[Journal Article] 高分解能立体構造から明らかにするPPARgの核輸送機構2023
- Author(s)
  藤間　祥子
- Journal Title
  
  薬学研究の進歩　研究成果報告集
  
  Volume: 39 Pages: 59-64
- Data Source
  KAKENHI-PROJECT-21K06031
[Journal Article] Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets2023
- Author(s)
  Matsuura Hiroaki、Sakai Naoki、Toma-Fukai Sachiko、Muraki Norifumi、Hayama Koki、Kamikubo Hironari、Aono Shigetoshi、Kawano Yoshiaki、Yamamoto Masaki、Hirata Kunio
- Journal Title
  
  Acta Crystallographica Section D Structural Biology
  
  Volume: 79 Issue: 10 Pages: 909-924
- DOI
  10.1107/s2059798323007039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06031, KAKENHI-PROJECT-22K06107, KAKENHI-PROJECT-23K05670, KAKENHI-PLANNED-19H05783
[Journal Article] Structural Diversity of Ubiquitin E3 Ligase2021
- Author(s)
  Toma-Fukai Sachiko、Shimizu Toshiyuki
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 21 Pages: 6682-6682
- DOI
  10.3390/molecules26216682
- Data Source
  KAKENHI-PROJECT-18K06077
[Journal Article] Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure2020
- Author(s)
  Toma-Fukai Sachiko、Hibi Ryota、Naganuma Takao、Sakai Mashito、Saijo Shinya、Shimizu Nobutaka、Matsumoto Michihiro、Shimizu Toshiyuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 43 Pages: 14630-14639
- DOI
  10.1074/jbc.ra120.013431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06077, KAKENHI-PROJECT-19K06516, KAKENHI-PLANNED-19H05781, KAKENHI-PROJECT-19H03713
[Journal Article] GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism2018
- Author(s)
  Shimizu Hikaru、Toma-Fukai Sachiko、Kontani Kenji、Katada Toshiaki、Shimizu Toshiyuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 38 Pages: 9563-9568
- DOI
  10.1073/pnas.1804740115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07351, KAKENHI-PROJECT-18K06077, KAKENHI-PROJECT-17H03981
[Journal Article] Novel helical assembly in arginine methyltransferase 82016
- Author(s)
  Toma-Fukai S, Kim JD, Park KE, Kuwabara N, Shimizu N, Krayukhina E, Uchiyama S, Fukamizu A, Shimizu T
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 428 Issue: 6 Pages: 1197-1208
- DOI
  10.1016/j.jmb.2016.02.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14707, KAKENHI-ORGANIZER-23116001, KAKENHI-PLANNED-23116004, KAKENHI-PLANNED-23116007, KAKENHI-PROJECT-25252062, KAKENHI-PROJECT-26840029, KAKENHI-WRAPUP-16H01688
[Presentation] Cryo-EM構造解析により明らかにするPPARgの核内輸送機構2024
- Author(s)
  藤間祥子、中村雄太郎、川本晃大、寺谷俊昭、清水光、廣瀬未果、端山浩輝、小島瑠莉, 吉村奏美, 石井雅樹、大畑慎也、岩崎憲治、加藤貴之、上久保裕生、伊藤俊将、冨田謙吾、清水敏之
- Organizer
  日本薬学会144年会
- Data Source
  KAKENHI-PROJECT-21K06031
[Presentation] 脳上衣腫原因融合タンパク質ZFTA-RelAの核内輸送機構の構造生物研究2023
- Author(s)
  藤間　祥子
- Organizer
  日本薬学会第１４３年会
- Data Source
  KAKENHI-PROJECT-21K06031
[Presentation] クライオ電子顕微鏡とX線結晶構造解析から明らかにするTransportin-1によるカーゴ認識機構の多様性2023
- Author(s)
  藤間祥子
- Organizer
  令和5年(2023年)度日本結晶学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06031
[Presentation] PPARg核内輸送機構の構造生物学的研究2022
- Author(s)
  藤間　祥子
- Organizer
  日本薬学会第１４２年会
- Data Source
  KAKENHI-PROJECT-21K06031
[Presentation] 脳上衣腫原因融合タンパク質ZFTA-RelAの核内輸送機構の構造研究2022
- Author(s)
  藤間　祥子
- Organizer
  令和4年(2022年)度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-21K06031
[Presentation] 階層的クラスタリングにより明らかになった脳上衣腫原因遺伝子ZFTA-RelAの核内輸送機構2021
- Author(s)
  藤間　祥子
- Organizer
  令和3年(2021年)度日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-21K06031
[Presentation] Crystal structure of GCN5 PCAF-homology domain reveals atypical ubiquitin ligase structure2020
- Author(s)
  日比亮太, 藤間祥子, 酒井真志人, 長沼孝雄, 松本道宏, 清水敏之
- Organizer
  第93 回日本生化学会大会（2020年）
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] Crystal structure of PCAF homology domain of GCN5 reveals its unique structure as ubiquitin E3 ligase2019
- Author(s)
  Sachiko TOMA-FUKAI, Ryota HIBI, Mashito SAKAI, Takao NAGANUMA, Shinya SAIJO, Nobutaka SHIMIZU, Michihiro MATSUMOTO, and Toshiyuki SHIMIZU
- Organizer
  International Symposium on Diffraction Structural Biology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] 創薬標的蛋白質のPX-BioSAXS相関構造解析の現状と今後の展望2019
- Author(s)
  藤間　祥子
- Organizer
  日本プロテオーム学会2019年大会第70回日本電気泳動学会総会（JPrOS・JES2019）
- Invited
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] Crystal structure of PCAF homology domain of GCN5 reveals its unique structure as ubiquitin E3 ligase2019
- Author(s)
  Sachiko TOMA-FUKAI, Ryota HIBI, Mashito SAKAI, Takao NAGANUMA, Shinya SAIJO, Nobutaka SHIMIZU, Michihiro MATSUMOTO, and Toshiyuki SHIMIZU
- Organizer
  AsCA2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] Structural basis of RhoA recognition by unique guanine nucleotide exchange factor SmgGDS2018
- Author(s)
  Hikaru SHIMIZU, Sachiko TOMA-FUKAI, Nobutaka SHIMIZU, Shinya SAIJO, Toshiaki KATADA, and Toshiyuki SHIMIZU
- Organizer
  AsCA 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] 細胞内創薬標的蛋白質の PX-BioSAXSを用いた構造機能相関解析2018
- Author(s)
  藤間祥子
- Organizer
  PF研究会多様な物質・生命科学研究に広がる小角散乱（他）分野の小角散乱を学ぼう！
- Invited
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] 新規ユビキチンE3リガーゼドメインmGCN5 PCAF-HDの結晶構造解析2018
- Author(s)
  日比亮太, 藤間祥子, 酒井真志人, 長沼孝雄, 松本道宏, 清水敏之
- Organizer
  日本結晶学会年会
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] 新規E3フォールド酵素PCAF-HDの構造科学研究2018
- Author(s)
  日比亮太, 藤間祥子, 酒井真志人, 長沼孝雄, 松本道宏, 清水敏之
- Organizer
  日本薬学会第139年会 (千葉)
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] 特異なグアニンヌクレオチド交換因子SmgGDSによるRhoA認識機構の構造基盤2018
- Author(s)
  清水光, 藤間祥子, 紺谷圈二, 堅田利明, 清水敏之
- Organizer
  PPF2018
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] Crystal structure of PCAF‐homology domain of GCN5 reveals its unique structure as ubiquitin E3 ligase2018
- Author(s)
  Ryota HIBI, Sachiko TOMA-FUKAI, Mashito SAKAI, Takao NAGANUMA, Michihiro MATSUMOTO, Toshiyuki SHIMIZU
- Organizer
  AsCA 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] リード化合物創成を目指した創薬標的蛋白質の構造機能相関解析2018
- Author(s)
  藤間祥子
- Organizer
  平成30年度第2回構造生物学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06077
[Presentation] Bifunctional enzyme PRMT8が担うPRMT,PLD活性発揮機構の構造生物学的解明2016
- Author(s)
  藤間祥子
- Organizer
  フォトンファクトリー研究会
- Place of Presentation
  高エネルギー加速器研究機構（茨城県つくば市）
- Year and Date
  2016-03-30
- Data Source
  KAKENHI-PLANNED-23116007

1. SATO Yoshinori (30150014)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. NOGUCHI Shuji (60237823)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 水谷隆太 (70272482)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Shimizu Toshiyuki (30273858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NAKAJIMA Yuka (40399499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 深水昭吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 金俊達

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 紺谷圏二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TOMA-FUKAI SACHIKO 深井 祥子 (藤間 祥子)

Toma-Fukai Sachiko 深井 祥子

藤間祥子

TOMA Sachiko 藤間 祥子

Research Projects

Research Products

Co-Researchers

Transportin-1が担う非古典的核輸送機構解明に向けた構造生物研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural study of the PCAF-HD domain of GCN5 to reveal signaling in hepatic glucogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of the transcription environment factors that engage in crosstalk with metabolic pathways

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure basis for ligand recognition and singnal inducing mechanism involved in TLR4・MD-2 complex.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural basis for ligand recognition of TLR4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト熱ショック蛋白質Hsp40コシャペロンの構造生物学研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

X-Ray Crystal Structure Analyses of Inante Immunological TLR-Related Receptor Proteins for Sepsis Treatments

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 高分解能立体構造から明らかにするPPARgの核輸送機構2023

Author(s)

Journal Title

Data Source

[Journal Article] Elucidating polymorphs of crystal structures by intensity-based hierarchical clustering analysis of multiple diffraction data sets2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural Diversity of Ubiquitin E3 Ligase2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure of GCN5 PCAF N-terminal domain reveals atypical ubiquitin ligase structure2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel helical assembly in arginine methyltransferase 82016

Author(s)

Journal Title

DOI

Data Source

[Presentation] Cryo-EM構造解析により明らかにするPPARgの核内輸送機構2024

Author(s)

TOMA-FUKAI SACHIKO 深井祥子 (藤間祥子)

Toma-Fukai Sachiko 深井祥子

TOMA Sachiko 藤間祥子