KOFUJI Takefumi 小藤剛史

… Alternative Names

小藤剛史コフジタケフミ

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Researcher Number	40365200
Affiliation (Current)	2025: 杏林大学, 医学部, 学内講師
Affiliation (based on the past Project Information) *help	2020 – 2023: 杏林大学, 医学部, 助教 2014 – 2018: 杏林大学, 医学部, 助教 2009: 杏林大学, 医学部, 助教 2007: 杏林大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Neurochemistry/Neuropharmacology Except Principal Investigator Neurochemistry/Neuropharmacology / Neurophysiology and muscle physiology / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 神経伝達物質 / グリア細胞 / シンタキシン１ / 精神神経疾患 / 神経伝達 / 抑制性シナプス / 神経科学 / 神経栄養因子 / 開口放出 / トランスポーター … More Except Principal Investigator … More syntaxin1A / syntaxin1B / 遺伝子ノックアウトマウス / シンタキシン1B / シンタキシン1A / シナプス伝達 / 細胞死 / syntaxin / SNARE / オートファジー / アルツハイマー / ERストレス / 脳・神経 / 神経科学 / ノックアウトマウス / 神経成長因子 / 開口放出 / シンタキシン１B / haploid / 自閉性障害 / 遅い神経伝達物質放出過程 / 速い神経伝達物質放出過程 / シンタキシン１Ｂ / シンタキシン１A / BDNF / グリア細胞 / 機能分化 / 神経伝達 / 疾患モデル / 自閉症 / シンタキシン1 / 運動障害 / 痙攣発作 / 致死 / 遅い神経伝達 / 速い神経伝達 / 行動異常 / シナプス伝達制御因子 / シナプス機能分化 / 疾患モデル動物 / ノックアウトマウス自閉性障害 Less

Role of glial cells on the symptoms of neuropsychiatric disorders in syntaxin1 gene ablated micePrincipal Investigator
- Principal Investigator
  
  小藤剛史
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kyorin University
Role of syntaxin1 in glial cells on the interaction between neurons and glial cellsPrincipal Investigator
- Principal Investigator
  
  Kofuji Takefumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyorin University
Role for ER stress responsive ER-Golgi SNARE in processing of Alzheimer`s disease-related protein and autophagy
- Principal Investigator
  
  Suga Kei
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyorin University
Functional difference between syntaxin1 isoforms in synaptic transmission
- Principal Investigator
  
  AKAGAWA kimio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Kyorin University
Analysis of syntaxin 1 gene knockout mice as an animal model for autistic disorder
- Principal Investigator
  
  AKAGAWA Kimio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyorin University

All 2024 2022 2021 2018 2017 2016 2014 2013 2012 2008 Other

All Journal Article Presentation

[Journal Article] Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes2024
- Author(s)
  Mishima T, Komano K, Tabaru M, Kofuji T, Saito A, Ugawa Y, Yasuo Terao
- Journal Title
  
  Front Cell Neurosci.
  
  Volume: 18 Pages: 1-14
- DOI
  10.3389/fncel.2024.1361242
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07926, KAKENHI-PROJECT-22K04134, KAKENHI-PROJECT-22K07943
[Journal Article] Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature dependent seizures2021
- Author(s)
  Tatsuya Mishima, Tomonori Fujiwara, Takefumi Kofuji, Ayako Saito, Yasuo Terao and Kimio Akagawa
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 156 Issue: 5 Pages: 604-613
- DOI
  10.1111/jnc.15159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07926
[Journal Article] Disturbance of the reciprocal-interaction between the OXTergic and DAergic systems in the CNS causes atypical social behavior in syntaxin 1A knockout mice2021
- Author(s)
  Fujiwara Tomonori、Kofuji Takefumi、Akagawa Kimio
- Journal Title
  
  Behavioural Brain Research
  
  Volume: 413 Pages: 113447-113447
- DOI
  10.1016/j.bbr.2021.113447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07926
[Journal Article] Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.2017
- Author(s)
  Fujiwara T, Kofuji T, Mishima T, Akagawa K
- Journal Title
  
  Eur J Neurosci.
  
  Volume: 46 Issue: 12 Pages: 2867-2874
- DOI
  10.1111/ejn.13779
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K01954, KAKENHI-PROJECT-16K07064
[Journal Article] A part of patients with autism spectrum disorder has haploidy of HPC-1/syntaxin1A gene that possibly caused behavioral disturbance as in experimentally gene ablated mice.2017
- Author(s)
  Kofuji T, Hayashi Y, Fujiwara T, Sanada M, Tamaru M, Akagawa K
- Journal Title
  
  Neuroscience letters
  
  Volume: 644 Pages: 5-9
- DOI
  10.1016/j.neulet.2017.02.052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07064, KAKENHI-PROJECT-16K01954
[Journal Article] Unusual social behavior in HPC-1/syntaxin1A knockout mice is caused by disruption of the oxytocinergic neural system2016
- Author(s)
  T Fujiwara, M Sanada, T Kofuj and K Akagawa
- Journal Title
  
  J Neurochem
  
  Volume: 138 Issue: 1 Pages: 117-23
- DOI
  10.1111/jnc.13634
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K01954, KAKENHI-PROJECT-16K07064
[Journal Article] Syntaxin 1B, but Not Syntaxin 1A, is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses2014
- Author(s)
  T.Mishima, T.fujiwara, M.Sanada, T.Kofuji ,M.Kanai &K.Akagawa
- Journal Title
  
  PLoS ONE.
  
  Volume: 9 Issue: 2 Pages: e90004-e90004
- DOI
  10.1371/journal.pone.0090004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300142, KAKENHI-PROJECT-24500462
[Journal Article] HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems.
- Author(s)
  T. Fujiwara, M. Sanada, T. Kofuji, T. Yoshikawa, K. Akagawa
- Journal Title
  
  Eur. J. Neurosci (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300133
[Presentation] シンタキシン１Ｂのハプロ不全による熱性けいれんの発症機序の解明2022
- Author(s)
  三嶋竜弥，小藤剛史，藤原智徳，齋藤綾子，寺尾安生
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20K07926
[Presentation] グリア細胞におけるシンタキシン１Ｂ欠損はＧＡＢＡ放出の異常を引き起こす2022
- Author(s)
  小藤剛史，三嶋竜弥，齋藤綾子，藤原智徳
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20K07926
[Presentation] Involvement of syntaxin 1B in the fever-associated epilepsy syndromes: Behavioral and neuronal phenotype of syntaxin 1B gene-ablated mice2018
- Author(s)
  Tatsuya Mishima, Tomonori Fujiwara, Takefumi Kofuji, Yasuo Terao and Kimio Akagawa
- Organizer
  FENS2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Syntaxin1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS2018
- Author(s)
  Tomonori Fujiwara, Takefumi Kofuji, Tatsuya Mishima and Kimio Akagawa
- Organizer
  FENS2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] シンタキシン1Bの熱性けいれんへの関与2018
- Author(s)
  三嶋竜弥、藤原智徳、小藤剛史、寺尾安生、赤川公朗
- Organizer
  第９５回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Role of syntaxin1 in glial cells on providing supportive functions for neurons through trophic support and transmitter uptake2018
- Author(s)
  Takefumi Kofuji, Tomonori Fujiwara, Tatsuya Mishima and Kimio Akagawa
- Organizer
  FENS2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] HPC-1/syntaxin 1A欠損マウスにおける社会行動障害の解析2018
- Author(s)
  藤原智徳、小藤剛史、三嶋竜弥、寺尾安生、赤川公朗
- Organizer
  第９５回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] シンタキシン1B遺伝子欠損マウスのけいれん表現型の解析2017
- Author(s)
  三嶋竜弥、藤原智徳、小藤剛史、寺尾安生、赤川公朗
- Organizer
  第９４回日本生理学会大会
- Place of Presentation
  浜松
- Year and Date
  2017-03-28
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Seizure phenotype in syntaxin1B gene ablated mice was associated with GABAergic system.2017
- Author(s)
  小藤剛史、藤原智徳、三嶋竜弥、赤川公朗
- Organizer
  第６０回日本神経化学会
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Disturbance of HPC-1/syntaxin1A gene expression and variation of its gene number are highly associated with autism spectrum disorder2017
- Author(s)
  Kofuji T, Fujiwara T, Mishima T, Sanada M, Hayashi Y, Tamaru M, Terao Y, Akagawa K
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] シンタキシン１Ｂ遺伝子欠損マウスの行動・神経機能の表現型解析：シンタキシン１Ｂの熱性けいれんへの関与2017
- Author(s)
  三嶋竜弥、藤原智徳、小藤剛史、寺尾安生、赤川公朗
- Organizer
  第４０回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] NMDA receptor 2B subunit and BK channel may affect mechanical allodynia by regulating the activity of enkepalinergic neurons in the spinal dorsal horn2017
- Author(s)
  Tanaka S, Kato E, Kofuji T, Fukushima T, Hori Y
- Organizer
  Experimental Biology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] A study on the behavioral and neuronal phenotype of syntaxin 1B gene-ablated mice: Involvement of syntaxin 1B in the feve-associated epilepsy syndromes2017
- Author(s)
  Mishima T, Fujiwara T, Kofuji T, Terao Y, Akagawa K
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Five cases of autism spectrum disorder with syntaxin1A gene haploid2017
- Author(s)
  Kofuji T, Hayashi Y, Fujiwara T, Tamaru M, Akagawa K
- Organizer
  14th Asian and Oceanian Congress of Child Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] HPC-1/syntaxin1A regulates reciprocal feedforward interactions between DA and OXT systems, which, in turn, affect social behavior2017
- Author(s)
  Fujiwara T, Kofuji T, Mishima T, Terao Y, Akagawa K
- Organizer
  Neuroscience2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Syntaxin1A遺伝子の欠損を認めた自閉症スペクトラムの５症例2016
- Author(s)
  林優子、小藤剛史、田丸政男、赤川公朗
- Organizer
  第５８回日本小児神経学会学術集会
- Place of Presentation
  東京
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] HPC-1/syntaxin1A is one of causing gene for autistic spectrum disorder2016
- Author(s)
  藤原智徳、小藤剛史、三嶋竜弥、林優子、田丸政男、赤川公朗
- Organizer
  第３９回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] Disturbance of HPC-1/syntaxin1A gene expression and its CNV cause autistic spectrum disorder2016
- Author(s)
  小藤剛史、藤原智徳、真田ますみ、三嶋竜弥、林優子、田丸政男、赤川公朗
- Organizer
  第５９回日本神経化学会
- Place of Presentation
  福岡
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-16K07064
[Presentation] STX1A, STX1B欠損マウスにおける行動異常の比較2013
- Author(s)
  藤原智徳、小藤剛史、三嶋竜也、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] 神経細胞の生存に対するHPC-1/シンタキシン１Ａとシンタキシン１Ｂの異なる役割2013
- Author(s)
  小藤剛史、藤原智徳、真田ますみ、三嶋竜也、赤川公朗
- Organizer
  日本神経科学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] Glial cells form STXIB-KO mice were less effective on neuronal survival than WT.2012
- Author(s)
  T. Kofuji
- Organizer
  日本神経化学会
- Place of Presentation
  神戸
- Year and Date
  2012-09-30
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] Impairment of HPA-axis in HPC-1/syntaxinlA knockout mice2008
- Author(s)
  Kofuji T
- Organizer
  日本神経化学会
- Place of Presentation
  富山
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19300133
[Presentation] HPC-1/syntaxin 1AノックアウトマウスにおけるHPA-axisの障害2008
- Author(s)
  小藤剛史
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19300133
[Presentation] 広汎性発達障害とsyntaxin1A遺伝子との関連性の検討
- Author(s)
  小藤剛史、林優子、田丸政男、赤川公朗
- Organizer
  日本小児神経学会
- Place of Presentation
  浜松
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] Impairment of social behavior in HP-C1/syntaxin1A knock out mice relate with reduction of DA and OXT release.
- Author(s)
  T.Fijiwara, T.Kofuji, M.Ｓａｎａｄａ　＆　Ｋ．Ａｋａｇａｗａ
- Organizer
  日本神経科学会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-24300142
[Presentation] 自閉症スペクトラム障害とHPC-1/syntaxinA遺伝子発現異常の関連性の検討
- Author(s)
  小藤剛史、林優子、藤原智徳、真田ますみ、田丸政男、赤川公朗
- Organizer
  日本神経化学会大会
- Place of Presentation
  奈良
- Year and Date
  2014-09-29 – 2014-10-01
- Data Source
  KAKENHI-PROJECT-24300142

1. MISHIMA Tatsuya (40317095)

# of Collaborated Projects: 5 results

# of Collaborated Products: 16 results
2. SAITOU Ayako (80424109)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SUGA Kei (30306675)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. AKAGAWA Kimio (80129303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
5. FUJIWARA Tomonori (90255399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
6. SANADA Masumi (70424108)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. NAKAYAMA Takahiro (90342823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOFUJI Takefumi 小藤 剛史

小藤 剛史 コフジ タケフミ

Research Projects

Research Products

Co-Researchers

Role of glial cells on the symptoms of neuropsychiatric disorders in syntaxin1 gene ablated micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of syntaxin1 in glial cells on the interaction between neurons and glial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role for ER stress responsive ER-Golgi SNARE in processing of Alzheimer`s disease-related protein and autophagy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional difference between syntaxin1 isoforms in synaptic transmission

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of syntaxin 1 gene knockout mice as an animal model for autistic disorder

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Repetitive pulsed-wave ultrasound stimulation suppresses neural activity by modulating ambient GABA levels via effects on astrocytes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Syntaxin 1B regulates synaptic GABA release and extracellular GABA concentration, and is associated with temperature dependent seizures2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Disturbance of the reciprocal-interaction between the OXTergic and DAergic systems in the CNS causes atypical social behavior in syntaxin 1A knockout mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A part of patients with autism spectrum disorder has haploidy of HPC-1/syntaxin1A gene that possibly caused behavioral disturbance as in experimentally gene ablated mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unusual social behavior in HPC-1/syntaxin1A knockout mice is caused by disruption of the oxytocinergic neural system2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Syntaxin 1B, but Not Syntaxin 1A, is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HPC-1/syntaxin 1A gene knockout mice show abnormal behavior possibly related to a disruption in 5-HTergic systems.

Author(s)

Journal Title

Data Source

[Presentation] シンタキシン１Ｂのハプロ不全による熱性けいれんの発症機序の解明2022

Author(s)

Organizer

Data Source

[Presentation] グリア細胞におけるシンタキシン１Ｂ欠損はＧＡＢＡ放出の異常を引き起こす2022

Author(s)

KOFUJI Takefumi 小藤剛史

小藤剛史コフジタケフミ