Okabe Seiichi 岡部聖一

… Alternative Names

OKABE Seiichi 岡部聖一

岡部聖一オカベセイイチ

Less

Researcher Number	40366109
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2011 – 2023: 東京医科大学, 医学部, 講師 2004 – 2005: 東京医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Tumor therapeutics / Basic Section 50020:Tumor diagnostics and therapeutics-related / Clinical oncology / Hematology
Keywords	Principal Investigator 分子標的治療 / 慢性骨髄性白血病 / 分子標的薬 / シグナル伝達 / 癌 / 白血病幹細胞 / 分子標的 / Ph陽性白血病 / AMPK / アポトーシス … More / depsipeptide(FK228) / 慢性骨髄性白血病(CML) / アセチル化 / depsipeptide / HDAC Less

低酸素下にある慢性骨髄性白血病幹細胞に対する新規治療法の構築Principal Investigator
- Principal Investigator
  
  岡部聖一
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Medical University
Regulation of Ph-positive leukemia stem cells by glutamate receptorsPrincipal Investigator
- Principal Investigator
  
  Okabe Seiichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Medical University
Mechanism of Ph positive leukemia cell maintenance by Hippo pathwayPrincipal Investigator
- Principal Investigator
  
  Okabe Seiichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Medical University
Targeting Hedgehog in a CML Stem Cell PathwayPrincipal Investigator
- Principal Investigator
  
  OKABE Seiichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Tokyo Medical University
HDAC阻害薬による白血病治療のメカニズム解析と有効性の確立Principal Investigator
- Principal Investigator
  
  岡部聖一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical University

All 2024 2023 2020 2017 2013 2012 2011 2006 2005

All Journal Article Presentation

[Journal Article] Effects of bortezomib on ponatinib-resistant Philadelphia chromosome-positive cells.2024
- Author(s)
  Okabe S, Moriyama M, Gotoh A.
- Journal Title
  
  Leuk Lymphoma.
  
  Volume: - Issue: 5 Pages: 696-699
- DOI
  10.1080/10428194.2024.2309308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07644
[Journal Article] Characterization of Asciminib-Resistant Philadelphia Chromosome-Positive Cells.2024
- Author(s)
  Okabe S, Moriyama M, Gotoh A.
- Journal Title
  
  World J Oncol.
  
  Volume: 15 Issue: 2 Pages: 319-324
- DOI
  10.14740/wjon1818
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07644
[Journal Article] Effect of asciminib and vitamin K2 on Abelson tyrosine-kinase-inhibitor-resistant chronic myelogenous leukemia cells2023
- Author(s)
  Okabe S, Gotoh A.
- Journal Title
  
  BMC Cancer
  
  Volume: 23 Issue: 1 Pages: 827-827
- DOI
  10.1186/s12885-023-11304-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07644
[Journal Article] WEE1 and PARP-1 play critical roles in myelodysplastic syndrome and acute myeloid leukemia treatment.2023
- Author(s)
  Okabe S, Tanaka Y, Moriyama M, Gotoh A.
- Journal Title
  
  Cancer Cell Int.
  
  Volume: 23 Issue: 1 Pages: 128-128
- DOI
  10.1186/s12935-023-02961-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07644, KAKENHI-PROJECT-22K07242
[Journal Article] Efficacy of dasatinib against ponatinib-resistant chronic myeloid leukemia cells.2020
- Author(s)
  Okabe S, Tanaka Y, Moriyama M, Gotoh A.
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 61 Issue: 1 Pages: 237-239
- DOI
  10.1080/10428194.2019.1660971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07227
[Journal Article] Effect of dual inhibition of histone deacetylase and phosphatidylinositol-3 kinase in Philadelphia chromosome-positive leukemia cells.2020
- Author(s)
  Okabe S, Tanaka Y, Moriyama M, Gotoh A.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 85 Issue: 2 Pages: 401-412
- DOI
  10.1007/s00280-019-04022-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07227
[Journal Article] argeting peroxisome proliferator-activated receptors: a novel strategy for Philadelphia chromosome-positive leukemia cells.2017
- Author(s)
  Okabe S, Tauchi T, Tanaka Y, Ohyashiki K.
- Journal Title
  
  Leuk Lymphoma
  
  Volume: 印刷中 Issue: 11 Pages: 2762-2764
- DOI
  10.1080/10428194.2017.1312373
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26430171
[Journal Article] Combination of Ponatinib with Hedgehog Antagonist Vismodegib for Therapy-Resistant BCR-ABL1-Positive Leukemia.2013
- Author(s)
  Katagiri S, Minami Y, Naoe T, et al.
- Journal Title
  
  Clin Cancer Res.
  
  Volume: 19 Issue: 6 Pages: 1422-1432
- DOI
  10.1158/1078-0432.ccr-12-1777
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390192, KAKENHI-PROJECT-23501312, KAKENHI-PROJECT-24390244, KAKENHI-PROJECT-24659461, KAKENHI-PUBLICLY-25112706, KAKENHI-PROJECT-25461412, KAKENHI-PUBLICLY-23112507
[Journal Article] Effects of the hedgehog inhibitor GDC-0449, alone or in combination with dasatinib, on BCR-ABL-positive leukemia cells.2012
- Author(s)
  Okabe S, Tauchi T, Tanaka Y, Katagiri S, Ohyashiki K.
- Journal Title
  
  Stem Cells Dev.
  
  Volume: 21 Issue: 16 Pages: 2939-48
- DOI
  10.1089/scd.2012.0016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501312
[Journal Article] Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45.2006
- Author(s)
  Okabe s et al.
- Journal Title
  
  Blood Cells Mol Dis. 36 2
  
  Pages: 308-314
- Data Source
  KAKENHI-PROJECT-16790547
[Journal Article] Peripheral T-cell lymphoma together with myelofibrosis with elevated plasma transforming growth factor-beta1.2005
- Author(s)
  Okabe s et al.
- Journal Title
  
  Leuk Lymphoma. 46 4
  
  Pages: 599-602
- Data Source
  KAKENHI-PROJECT-16790547
[Presentation] Targeting the hedgehog signaling pathway limits the self-renewal of BCR-ABL1 positive leukemia cells2013
- Author(s)
  田内哲三、片桐誠一朗、岡部聖一、南陽介、直江知樹、大屋敷一馬
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2013-10-11
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] 治療抵抗性BCR-ABL1 陽性白血病に対するponatinib を併用したhedgehog 経路の標的療法2012
- Author(s)
  片桐誠一朗、田内哲三、岡部聖一、木村晋也、前川平、大屋敷一馬
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Year and Date
  2012-10-19
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Targeting the Hedgehog Signaling Pathway Limits the Self-Renewal of BCR-ABL1 Positive Leukemia Cells: Molecular Mechanisms2012
- Author(s)
  Tetsuzo Tauchi, Seiichiro Katagiri, Seiichi Okabe, Yosuke Minami, Tomoki Naoe, Kazuma Ohyashiki
- Organizer
  AMER SOC HEMATOLOGY
- Place of Presentation
  Atlanta
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Targeting the Hedgehog Signaling Pathway Limits the Self-Renewal of BCR-ABL1 Positive Leukemia Cells : Molecular Mechanisms2012
- Author(s)
  Tauchi T, Katagiri S, Okabe S, Minami Y, Naoe T, Ohyashiki K
- Organizer
  54th ASH Annual Meeting and Exposition
- Place of Presentation
  アトランタ
- Year and Date
  2012-12-10
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Combined effects of Ponatinib and Dasatinib against T315I mutant forms of BCR-ABL12012
- Author(s)
  Tauchi Tetsuzo, Katagiri Seiichiro, Okabe Seiichi, Kimura Shinya, Maekawa Taira, Ohyashiki Kazuma
- Organizer
  臨床血液
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Combining ABL1 Kinase Inhibitor, Imatinib and the Jak Kinase Inhibitor TG101348: A Potential Treatment for Residual BCR-ABL Positive Leukemia Cells2012
- Author(s)
  Okabe Seiichi, Tauchi Tetsuzo, Katagiri Seiichiro, Tanaka Yuko, Ohyashiki Kazuma
- Organizer
  AMER SOC HEMATOLOGY
- Place of Presentation
  Atlanta
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Activity of the Aurora Kinase Inhibitor, MLN8237 (alisertib) Alone or in Combination with Ponatinib Against Imatinib-Resistant BCR-ABL-Positive Cells2012
- Author(s)
  Okabe Seiichi, Tauchi Tetsuzo, Katagiri Seiichiro, Tanaka Yuko, Ohyashiki Kazuma
- Organizer
  AMER SOC HEMATOLOGY
- Place of Presentation
  Atlanta
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Targeting the Hedgehog pathway in therapy-resistant BCR-ABL1 positive leukemia with ponatinib2012
- Author(s)
  Katagiri Seiichiro, Tauchi Tetsuzo, Okabe Seiichi, Kimura Shinya, Maekawa Taira, Ohyashiki Kazuma
- Organizer
  臨床血液
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Co-treatment with ponatinib and HDAC inhibitor vorinostat: A treatment for Ph-positive cells2012
- Author(s)
  Okabe Seiichi, Tauchi Tetsuzo, Kimura Shinya, Maekawa Taira, Ohyashiki Kazuma
- Organizer
  臨床血液
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] BCR-ABL陽性細胞に対するhedgehog inhibitor の単独およびdasatinib 併用の効果2011
- Author(s)
  岡部聖一、田内哲三、大屋敷一馬
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Targeting the Hedgehog Signaling Pathway in Therapy-Resistant BCR-ABL1 Positive Leukemia with Ponatinib2011
- Author(s)
  Seiichiro Katagiri, M.D.1*, Tetsuzo Tauchi, M.D.1*, Seiichi Okabe, M.D.1*, Eishi Ashihara, MD, PhD2, Shinya Kimura, MD, PhD3*, Taira Maekawa, MD, DMSci2* and Kazuma Ohyashiki, MD, PhD1
- Organizer
  53rd ASH（American Society of Hematology） Annual Meeting
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Targeting the hedgehog signaling pathway in therapy-resistant Bcr-Abl1 positive leukemia with ponatinib2011
- Author(s)
  Katagiri S, Tauchi T, Okabe S, Ashihara E, Kimura S, Maekawa T, Ohyashiki K
- Organizer
  The 53rd American Society of Hematology Annual Meeting and Exposition
- Place of Presentation
  サンディエゴ
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Combined Effects of a Pan-ABL1 Kinase Inhibitor, Ponatinib and Dasatinib Against T315I Mutant Forms of BCR-ABL1: In Vitro and In Vivo Studies2011
- Author(s)
  Tetsuzo Tauchi, M.D.1*, Seiichiro Katagiri, M.D.1*, Seiichi Okabe, M.D.1*, Eishi Ashihara, MD, PhD2, Shinya Kimura, MD, PhD3*, Taira Maekawa, MD, DMSci2* and Kazuma Ohyashiki, MD, PhD1
- Organizer
  53rd ASH（American Society of Hematology） Annual Meeting
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-23501312
[Presentation] Combining ABL1 Kinase Inhibitor, Ponatinib and the Histone Deacetylase (HDAC) Inhibitor Vorinostat: A Potential Treatment for BCR-ABL Positive Leukemia Cells2011
- Author(s)
  Seiichi Okabe, M.D.1*, Tetsuzo Tauchi, MD, PhD1*, Shinya Kimura, MD, PhD2*, Taira Maekawa, MD, PhD3* and Kazuma Ohyashiki, MD, PhD1
- Organizer
  53rd ASH（American Society of Hematology） Annual Meeting
- Place of Presentation
  San Diego, California
- Data Source
  KAKENHI-PROJECT-23501312

1. 片桐誠一朗 (50532298)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 木口亨 (70453727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 伊藤良和 (10287120)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 直江知樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 南陽介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Okabe Seiichi 岡部 聖一

OKABE Seiichi 岡部 聖一

岡部 聖一 オカベ セイイチ

Research Projects

Research Products

Co-Researchers

低酸素下にある慢性骨髄性白血病幹細胞に対する新規治療法の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of Ph-positive leukemia stem cells by glutamate receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of Ph positive leukemia cell maintenance by Hippo pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Targeting Hedgehog in a CML Stem Cell PathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HDAC阻害薬による白血病治療のメカニズム解析と有効性の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of bortezomib on ponatinib-resistant Philadelphia chromosome-positive cells.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of Asciminib-Resistant Philadelphia Chromosome-Positive Cells.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of asciminib and vitamin K2 on Abelson tyrosine-kinase-inhibitor-resistant chronic myelogenous leukemia cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] WEE1 and PARP-1 play critical roles in myelodysplastic syndrome and acute myeloid leukemia treatment.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of dasatinib against ponatinib-resistant chronic myeloid leukemia cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of dual inhibition of histone deacetylase and phosphatidylinositol-3 kinase in Philadelphia chromosome-positive leukemia cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] argeting peroxisome proliferator-activated receptors: a novel strategy for Philadelphia chromosome-positive leukemia cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combination of Ponatinib with Hedgehog Antagonist Vismodegib for Therapy-Resistant BCR-ABL1-Positive Leukemia.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of the hedgehog inhibitor GDC-0449, alone or in combination with dasatinib, on BCR-ABL-positive leukemia cells.2012

Author(s)

Journal Title

DOI

Okabe Seiichi 岡部聖一

OKABE Seiichi 岡部聖一

岡部聖一オカベセイイチ