Horishita Takafumi 堀下貴文

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HORISHITA Takafumi 堀下貴文

HORISHITA Takahumi 堀下貴文

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Researcher Number	40369070
Affiliation (Current)	2025: 産業医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 産業医科大学, 医学部, 教授 2015 – 2019: 産業医科大学, 医学部, 准教授 2009 – 2014: University of Occupational and Environmental Health, Japan, 医学部, 講師 2006: 産業医大, 医学部, 助手 2003 – 2005: 産業医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / Anesthesiology/Resuscitation studies / Anesthesiology Except Principal Investigator Anesthesiology/Resuscitation studies / Basic Section 55050:Anesthesiology-related / Anesthesiology/Resuscitation studies / Anesthesiology
Keywords	Principal Investigator 新たな鎮痛薬開発 / 慢性疼痛 / 先天性無痛症 / 電位依存性ナトリウムチャネル / 神経障害性疼痛 / 内因性カンナビノイド / アロプレグナノロン / アフリカツメガエル卵母細胞発現系 / ニューロステロイド / 電気生理学的解析 … More / 機能獲得型Nav1.9 / 新規鎮痛薬・鎮痛法の開発 / 病態機序解明 / Nav1.7機能喪失 / Nav1.7と痛み受容体の相互関係 / 先天性無痛症の病態解明 / 局所麻酔作用 / 機能喪失型Nav1.7 / 選択的Nav1.9阻害薬 / Nav1.9抑制機序 / 新たな鎮痛薬 / Nav1.9 / 抗うつ薬 / TRPA1受容体 / TRPM8受容体 / 温度感受性受容体 / 冷感アロディニア / 疼痛抑制機序の解明 / アナンダマイド / 疼痛機構 / PS / 麻酔作用 / ニユーロステロイド / プレグナノロン / 作用機序 / 疼痛機序 / 鎮痛作用 / ニューステロイド / ナトリウムチャネル / 疼痛管理学 / 細胞内カルシウム上昇抑制 / サブスタンスP受容体 / Gタンパク結合受容体 / 細胞内カルシウム濃度測定 / ラット培養DRG細胞 / 脊髄 / 抗侵害作用 / プレグネノロン / Na_v1.4 / Na_v1.2 / Naチャネル … More Except Principal Investigator アフリカツメガエル卵母細胞発現系 / 麻酔薬 / 神経障害性疼痛 / 慢性疼痛 / Anesthetics / Xenopus oocyte / Protein Kinase C (PKC) / ハロセン / エンフルラン / イソフルラン / 鎮痛薬 / 新たな鎮痛薬開発 / 細胞内リン酸化酵素 / 電気生理学的解析 / ASIC機能抑制機序 / 酸感受性イオンチャネル（ASIC） / 新規鎮痛薬開発 / α9AChRの抑制機序解明 / α9AChR / ニコチン性アセチルコリン受容体(nAChR) / アフリカツメガエル卵母細胞 / 脊椎後根神経節細胞 / オピオイド / ナトリウム　チャンネル / 培養脊髄後根神経節細胞 / TRP / 培養脊椎後根神経節細胞 / アフリカツメガエル卵母細胞発現 / Ｇ蛋白共役型受容体 / オピドイド受容体 / 電位依存性Na+チャネル / ロピバカイン / メピバカイン / リドカイン / TRPV3 / オピオイド受容体 / 電位依存性Naチャネル(Nav) / カルバクロール / バニロイド受容体サブタイプ3 / オピオイド受容体（OR） / Nav1.7 / 局所麻酔薬 / Phosphorylation / Dexmedetomidine / Xenopus oocytes expression systems / Metabotropic glutamte receptors / Dorsal root ganglia cells / G protein couples receptors / Pain mechanism / メタボトロピックグルタミン酸受容体(cGluR) / 脊髄後根神経節(Dorsal Root Gnglia, DRG)細胞 / 脊髄後根神経節(DRG)細胞 / G蛋白結合受容体(GPCR) / デクスメデトミジン / アフリカツメガエル卵母細胞系 / メタボトロピックグルタミン酸受容体(mGluR) / 脊髄後根神経節(Dorsal Root Ganglia, DRG)細胞 / G蛋白共役型受容体(GPCR) / 疼痛メカニズム / orexin A / Tramadol / substance P / G-protein coupled receptor (GPCR) / ion channels / dorsal root ganglia cells / G蛋白結合受容体 / イオンチャンネル / 疼痛発生メカニズム / エーテル / 静脈麻酔薬 / ステロイド系静脈麻酔薬アルファキサロン / 電位依存性Naチャネル / オレキシンA / トラマドール / サブスタンスP / G蛋白共役型受容体 / イオンチャネル / 脊髄後根神経節 / 吸入麻酔薬 / Halothane / Enflurane / Isoflurane / Protein G / Cannabinoid Receptor / Gq蛋白 / Gi / Ca^<2+>依存性Cl^-チャネル / G蛋白質共役型受容体 / Protein Kinase C(PKC) / G蛋白 / カナビノイド受容体 / Nav1.3選択的阻害薬 / Nav1.3サブユニット / 電位依存性ナトリウムチャネル / P2X受容体 / 全身麻酔薬 / 癌性疼痛 / P2X_7受容体 / P2X_4受容体 / 疼痛発現機構 / サブユニット選択的作用 / P2X7受容体 / ATP受容体 / 疹痛管理学 / ^3H-thymidine / 静脈性麻酔ケタミン / 動脈平滑筋 / 生活習慣病 / 動脈硬化 / 血管障害性動脈硬化 / [^3H]-thymidine / 細胞内cAMP / 静脈性麻酔薬ケタミン / 血管平滑筋増殖 / Alphaxalone / 副腎髄質細胞 / ニコチン受容体 / ムスカリン受容体 / ニューロステロイド Less

難治性慢性疼痛に対する選択的ASIC阻害薬開発を目指したASIC抑制機構の解明
- Principal Investigator
  
  濱田高太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
新規鎮痛薬開発を目指した、機能獲得型Nav1.9による先天性無痛症の病態解明Principal Investigator
- Principal Investigator
  
  堀下貴文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
難治性慢性疼痛に対する新規鎮痛薬開発を目指したα9 nACh受容体抑制機序の解明
- Principal Investigator
  
  緒方裕一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Elucidation of pathological mechanism of congenital insensitivity to pain with loss of Nav1.7 function for the development of new analgesics and analgesic methodsPrincipal Investigator
- Principal Investigator
  
  Horishita Takafumi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Functional analysis of voltage-gated sodium channel in anesthesia mechanism using dorsal root ganglion cells
- Principal Investigator
  
  MINAMI KOUICHIRO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Jichi Medical University
Investigation of the mechanisms of Nav1.9 inhibition aimed at development of selective Nav1.9 inhibitor for chronic painPrincipal Investigator
- Principal Investigator
  
  Horishita Takafumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  University of Occupational and Environmental Health, Japan
Elucidation of the mechanisms underlying inhibition of TRPM8 receptor aimed at development of novel analgesics to treat cold allodyniaPrincipal Investigator
- Principal Investigator
  
  HORISHITA Takafumi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  University of Occupational and Environmental Health, Japan
Analysis of the mechanisms underlying inhibition of voltage-gated sodium channel aimed at development of selective inhibitor on Nav1.3
- Principal Investigator
  
  SATA Takeyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  University of Occupational and Environmental Health, Japan
Analysis of the mechanisms of pain relief by endocannabinoids aimed at development of analgesics for neuropathic painPrincipal Investigator
- Principal Investigator
  
  HORISHITA Takafumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
Investigations of painmechanism related to ATP receptors aiming at new analgesics for cancer pain
- Principal Investigator
  
  SATA Takeyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
Analysis of the action mechanisms of volatile anesthetics and analgesics aimed at development of selective sodium channel blockerPrincipal Investigator
- Principal Investigator
  
  HORISHITA Takafumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
The role of the metabotropic gultamete receptor in the pain mechanism
- Principal Investigator
  
  SHIGA Yousuke
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
麻酔薬の動脈硬化予防作用の臨床応用を目指した研究-麻酔薬の新たなる作用の検討-
- Principal Investigator
  
  SHIGEMATSU Akio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
ニューロステロイドの鎮痛機序解明を目指した中枢-脊髄-末梢神経での総合的解析Principal Investigator
- Principal Investigator
  
  堀下貴文
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
The study of antinociceptive effects of anesthetics and analgesics using dorsal root ganglia cells.
- Principal Investigator
  
  SHIGEMATSU Akio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational Environmental Health(UOEH)
ニューロステロイドのG蛋白結合受容体及びリガンド結合イオンチャンネルに及ぼす影響
- Principal Investigator
  
  MINAMI Kouitiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
The effects of anesthetics and ethanol on cannabinoid receptor function.
- Principal Investigator
  
  KAMOCHI Masayuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan

All 2021 2020 2019 2017 2015 2014 2013 2012 2011 2010 2007 2005 2002 Other

All Journal Article Presentation Book

[Book] Basic and Systemic Mechanisms of Anesthesia (Volatile anesthetics, enflurane, isoflurane inhibit 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. pp277-278)2005
- Author(s)
  Horishita T., et al.
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-17591657
[Book] Basic an dSystemic Mechanisms of Anesthesia8Bolatile anesthetics, enflurane, isoflurane inhibit 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes.pp277-278)2005
- Author(s)
  Horishita T., et al.
- Publisher
  ELSEVIER
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390479
[Book] Basic and Systemic Mechanisms of Anesthesia (Volatile anesthetics, enflurane, isoflurane inhibit 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes.2005
- Author(s)
  Horishita T., et al.
- Total Pages
  342
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-16659429
[Book] Basic and Systemic Mechanisms of Anesthesia (Volatile anesthetics, enflurane, isoflurane inhibit 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes, pp277-278)2005
- Author(s)
  Horishita T., et al.
- Total Pages
  342
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-16790905
[Book] Basic and Systemic Mechanisms of Anesthesia (Volatile anesthetics, enflurane, isoflurane inhibit 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. pp277-278)2005
- Author(s)
  Horishita T., et al.
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] Local Anesthetics Inhibit Transient Receptor Potential Vanilloid Subtype 3 Channel Function in Xenopus Oocytes2021
- Author(s)
  Reiko Horishita, Yuichi Ogata, Ryo Fukui, Ryo Yamazaki, Kuniaki Moriwaki, Susumu Ueno, Nobuyuki Yanagihara, Yasuhito Uezono, Yuka Yokoyama, Kouichiro Minami, Takafumi Horishita
- Journal Title
  
  Anesth Analg
  
  Volume: 1756-1767 Issue: 6 Pages: 1756-1767
- DOI
  10.1213/ane.0000000000005546
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09382, KAKENHI-PROJECT-21K06584
[Journal Article] Carvacrol inhibits the neuronal voltage-gated sodium channels Nav1.2, Nav1.6, Nav1.3, Nav1.7, and Nav1.8 expressed in Xenopus oocytes with different potencies2020
- Author(s)
  Horishita Takafumi、Ogata Yuichi、Horishita Reiko、Fukui Ryo、Moriwaki Kuniaki、Ueno Susumu、Yanagihara Nobuyuki、Uezono Yasuhito、Sudo Yuka、Minami Kouichiro
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 142 Issue: 4 Pages: 140-147
- DOI
  10.1016/j.jphs.2019.12.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09382, KAKENHI-PROJECT-18K07404
[Journal Article] The endocannabinoid anandamide inhibits voltage-gated sodium channels NaV1.2, NaV1.6, NaV1.7 and NaV1.8 in Xenopus Oocytes.2014
- Author(s)
  Okura D, Horishita T, Ueno S, Yanagihara N, Sudo Y, Uezono Y, Sata T.
- Journal Title
  
  Anesth Analg
  
  Volume: 118 Issue: 3 Pages: 554-562
- DOI
  10.1213/ane.0000000000000070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590740, KAKENHI-PROJECT-24592369, KAKENHI-PROJECT-25860200
[Journal Article] Effects of anesthetics on the function of orexiir 1 receptors expressed in Xen op us oocytes.2007
- Author(s)
  Minami K, Uezono Y, Sakurai T, Horishita T, Shiraishi M, Ueta Y.
- Journal Title
  
  Pharmacology. 79(4)
  
  Pages: 236-42
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591657
[Journal Article] Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenop us oocytes and muscarine induced intracellular Ca^<2+> elevation in cultured rat dorsal root ganglia cells.2007
- Author(s)
  Takizuka A, Minami K, Uezono Y, Horishita T, Yokoyama T, Shiraishi M, Sakurai T, Shigematsu A, Ueta Y.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol. 375(5)
  
  Pages: 293-301
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591657
[Journal Article] The effects of the neurosteroids : Progesterone and Dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M_1 and M_3 receptors.2005
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacil 371・3
  
  Pages: 221-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] The effects of the neurosteroids : Pregnenolone, Progesterone and Dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M_1 and M_3 receptors.2005
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol 371・3
  
  Pages: 221-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] Alphaxalone, a neurosteroid anesthetic, inhibits norepinephrine transporter function in cultured bovine adrenal medullary cells.2002
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Anesth Analg 95・6
  
  Pages: 1661-1666
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571479
[Journal Article] The Tramadol Metabolite, O-desmethyl Tramadol, Inhibits 5-Hydroxytryptamine Type 2C Recrptors Expressed in Xenopus Oocytes.
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Pharmacology (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] The effects of the neurosteroids : Pregnenolone, Progesterone and Dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M1 and M3 receptors.
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology (In press)
- Data Source
  KAKENHI-PROJECT-16790905
[Journal Article] The effects of the neurosteroids : Pregnenolone, Progesterone and Dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M1 and M3 receptors.
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology (In press)
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] The Tramadol Metabolite, O-desmethyl Tramadol, Inhibits 5-Hydroxytryptamine Type 2C Receptors Expressed in Xenopus Oocytes
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Pharmacology (In press)
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] The effects of the neurosteroids : Pregnenolone, Progesterone and Dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M1 and M3 receptors.
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571479
[Journal Article] The Tramadol Metabolite, 0-desmethyl Tramadol, Inhibits 5-Hydroxytryptamine Type 2C Receptors Expressed in Xenopus Oocytes
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Pharmacology (In press)
- Data Source
  KAKENHI-PROJECT-16790905
[Journal Article] The Tramadol Metabolite, 0-desmethyl Tramadol, Inhibits 5-Hydroxytryptamine Type 2C Receptors Expressed in Xenopus Oocytes
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Pharmacology (In press)
- Data Source
  KAKENHI-PROJECT-16659429
[Journal Article] The effects of the neurosteroids : Pregnenolone, Progesterone and Dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M_1 and M_3 receptors
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571479
[Journal Article] The effects of the neurosteroids : Pregnenolone, Progesterone and Dehydroepiandrosterone on muscarinic receptor-induced responses in Xenopus oocytes expressing M1 and M3 receptors.
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Naunyn-Schmiedeberg's Archives of Pharmacology In press
- Data Source
  KAKENHI-PROJECT-14571479
[Journal Article] The Tramadol Metabolite, O-desmethyl Tramadol, Inhibits 5-Hydroxytryptamine Type 2C Receptors Expressed in Xenopus Oocytes
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Pharmacology (In press)
- Data Source
  KAKENHI-PROJECT-17591657
[Journal Article] The Tramadol Metabolite, O-desmethyl Tramadol, Inhibits 5-Hydroxytryptamine Type 2C Receptors Expressed in Xenopus Oocytes.
- Author(s)
  Horishita T., et al.
- Journal Title
  
  Pharmacology (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390479
[Presentation] 止痢薬ロペラミドは温度感受性TRPチャネルファミリー，TRPM8機能を抑制する2020
- Author(s)
  福井遼，緒方裕一，森脇邦明，堀下玲子，堀下貴文
- Organizer
  日本麻酔科学会第67回学術集会
- Data Source
  KAKENHI-PROJECT-19K09382
[Presentation] クロルプロマジンは電位依存性ナトリウムチャネルαサブユニット、Nav1.2、Nav1.3、Nav1.6、Nav1.7、Nav1.8機能を抑制する2019
- Author(s)
  堀下貴文、堀下玲子、南智子、緒方裕一、川﨑貴士
- Organizer
  日本麻酔科学会第66回学術集会
- Data Source
  KAKENHI-PROJECT-18K08876
[Presentation] Lidocaine inhibits 2APB-induced currents of TRPV3 channels expressed in Xenopus oocytes2017
- Author(s)
  Reiko Horishita, Takafumi Horishita, Dan Okura, Tomoko Minami, Yuichi Ogata, Takashi Kawasaki
- Organizer
  2017 Annual meeting, American Society of Anesthesiologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10567
[Presentation] カルバクロールは、電位依存性ナトリウムチャネルαサブユニット、Nav1.2、Nav1.3、Nav1.6、Nav1.7、Nav1.8機能を抑制する2015
- Author(s)
  堀下貴文、大倉暖、土山玲子、南智子、熊倉美佳、佐多竹良
- Organizer
  日本麻酔科学会第62回学術集会
- Place of Presentation
  神戸ポートピアホテル（兵庫県神戸市）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-25462462
[Presentation] 温度感受性TRPチャネルサブファミリー、TRPA1に対するガバペンチンの影響2015
- Author(s)
  土山玲子、堀下貴文、大倉暖、南智子、佐多竹良
- Organizer
  日本麻酔科学会第62回学術集会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-15K10567
[Presentation] リドカインはATP受容体サブタイプ、P2×_7受容体機能を抑制する2013
- Author(s)
  大倉暖、堀下貴文、佐多竹良
- Organizer
  日本麻酔科学会第60回学術集会
- Place of Presentation
  札幌(ロイトン札幌)
- Year and Date
  2013-05-23
- Data Source
  KAKENHI-PROJECT-22591756
[Presentation] 電位依存性ナトリウムチャネルサブユニット、Nav1.3に対する抗うつ薬の影響2013
- Author(s)
  堀下貴文
- Organizer
  日本麻酔科学会第60回学術集会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-25462462
[Presentation] 抗うつ薬の電位依存性ナトリウムチャネルに対する影響2012
- Author(s)
  堀下貴文
- Organizer
  日本麻酔科学会第59回学術集会
- Place of Presentation
  神戸市（神戸ポートピアホテル）
- Data Source
  KAKENHI-PROJECT-24592369
[Presentation] 内因性カンナビノイド、アナンダマイドの電位依存性ナトリウムチャネルに対する影響2011
- Author(s)
  堀下貴文
- Organizer
  日本麻酔科学会第58回学術集会
- Place of Presentation
  神戸国際展示場(神戸)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-21791480
[Presentation] 内因性カンナビノイド、アナンダマイドの電位依存性ナトリウムチャネルに対する影響2011
- Author(s)
  堀下貴文
- Organizer
  日本麻酔科学会第58回学術集会
- Place of Presentation
  神戸国際会議場(神戸)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-21791480
[Presentation] ニューロステロイドの電位依存性ナトリウムチャネルNav1.2機能に対する影響2010
- Author(s)
  堀下貴文
- Organizer
  日本麻酔科学会第57回学術集会
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-21791480
[Presentation] ニューロステロイドの電位依存性ナトリウムチャネルNa_v1.2機能に対する影響2010
- Author(s)
  堀下貴文、佐多竹良
- Organizer
  日本麻酔科学会第57回学術集会
- Place of Presentation
  福岡(福岡国際会議場)
- Year and Date
  2010-06-03
- Data Source
  KAKENHI-PROJECT-21791480

1. MINAMI Kouitiro (70279347)

# of Collaborated Projects: 6 results

# of Collaborated Products: 4 results
2. OOKURA Dan (00596710)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
3. UEZONO Yasuhito (20213340)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
4. SATA Takeyoshi (60128030)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
5. SHIRAISHI Munehiro (40389458)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
6. SHIGEMATSU Akio (30037428)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 尾方純一 (50352331)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KAMOCHI Masayuki (90204643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UETA Yoichi (10232745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIGA Yousuke (10399199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HORISHITA Reiko (40746658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. 渋谷泉 (50162649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松井稔 (50282611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 緒方裕一 (80746660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 濱田高太郎 (70461580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Horishita Takafumi 堀下 貴文

HORISHITA Takafumi 堀下 貴文

HORISHITA Takahumi 堀下 貴文

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新規鎮痛薬開発を目指した、機能獲得型Nav1.9による先天性無痛症の病態解明Principal Investigator

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Elucidation of pathological mechanism of congenital insensitivity to pain with loss of Nav1.7 function for the development of new analgesics and analgesic methodsPrincipal Investigator

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Investigation of the mechanisms of Nav1.9 inhibition aimed at development of selective Nav1.9 inhibitor for chronic painPrincipal Investigator

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Elucidation of the mechanisms underlying inhibition of TRPM8 receptor aimed at development of novel analgesics to treat cold allodyniaPrincipal Investigator

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Analysis of the mechanisms of pain relief by endocannabinoids aimed at development of analgesics for neuropathic painPrincipal Investigator

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Analysis of the action mechanisms of volatile anesthetics and analgesics aimed at development of selective sodium channel blockerPrincipal Investigator

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ニューロステロイドの鎮痛機序解明を目指した中枢-脊髄-末梢神経での総合的解析Principal Investigator

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Horishita Takafumi 堀下貴文

HORISHITA Takafumi 堀下貴文

HORISHITA Takahumi 堀下貴文