SHIMUTA KEN 志牟田健

… Alternative Names

Shimuta Ken 志牟田健

SHIMUTA Ken 志牟田健

志牟田健シムタケン

Less

Researcher Number	40370960
Other IDs	https://orcid.org/0000-0002-1416-4116
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所細菌第一部, 主任研究員
Affiliation (based on the past Project Information) *help	2024: 国立感染症研究所, 細菌第一部, 主任研究官 2016 – 2021: 国立感染症研究所, 細菌第一部, 主任研究官 2009 – 2010: National Institute of Infectious Diseases, 細菌第一部, 主任研究官 2007 – 2008: National Institute of Infectious Diseases, Dep. of Bacteriology, Principle investigator 2006: 国立感染症研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / Urology Except Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including Mycology) / Social dentistry
Keywords	Principal Investigator 淋菌感染症 / Point of care testing / 薬剤耐性淋菌 / LMAP法 / STI / 性感染症 / 尿路感染症 / 細胞周期 Except Principal Investigator 自然形質転換 / セフトリアキソン … More / 薬剤耐性 / 形質転換 / 淋菌 / competitive growth inhibition / urinary tract infection / extra-intestinal pathogenic Escherichia coli / pathogenic bacteria / 大腸菌 / PFGE / 競争的排除 / 病原性大腸菌 / 競争阻害 / 尿路感染症 / 腸管外病原性大腸菌 / 病原細菌 / Fusobacterium nucleatum / 検査 / 唾液 / バイオフィルム / 歯周病 / ペプチドアレイ / hemagglutinin / Porphyromonas gingivalis / Streptococcus gordonii Less

DETECTR法による淋菌の薬剤感受性判定法の開発Principal Investigator
- Principal Investigator
  
  志牟田健
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  National Institute of Infectious Diseases
LAMP法による簡易的な淋菌の薬剤感受性判定を可能とするアッセイ系の開発Principal Investigator
- Principal Investigator
  
  志牟田健
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  National Institute of Infectious Diseases
Origin of drug resistant gene of Neisseria gonorrhoeae.
- Principal Investigator
  
  Ohnishi Makoto
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  National Institute of Infectious Diseases
Diversity of Neisseria gonorrhoeae strains in the host responsePrincipal Investigator
- Principal Investigator
  
  Shimuta Ken
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  National Institute of Infectious Diseases
Analysis of the cell cycle in infected culture cell of Neisseria gonorrhoeae.Principal Investigator
- Principal Investigator
  
  SHIMUTA Ken
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  National Institute of Infectious Diseases
ポストゲノム時代に対応した歯周病リスク診断用ペプチドアレイの構築
- Principal Investigator
  
  泉福英信
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Social dentistry
- Research Institution
  National Institute of Infectious Diseases
Model for evaluation of pathogenicity of extra-intestinal pathogenic Escherichia coli
- Principal Investigator
  
  OHNISHI Makoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  National Institute of Infectious Diseases

All 2021 2020 2019 2018 2017 2016 2011 2010

All Journal Article Presentation

[Journal Article] Molecular characterization of <i>Neisseria gonorrhoeae</i> isolates collected through a national surveillance programme in Japan, 2013: evidence of the emergence of a ceftriaxone-resistant strain from a ceftriaxone-susceptible lineage2021
- Author(s)
  Hanao Mami、Aoki Kotaro、Ishii Yoshikazu、Shimuta Ken、Ohnishi Makoto、Tateda Kazuhiro
- Journal Title
  
  Journal of Antimicrobial Chemotherapy
  
  Volume: 76 Issue: 7 Pages: 1769-1775
- DOI
  10.1093/jac/dkab104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02659
[Journal Article] Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae2021
- Author(s)
  Yahara Koji、Ma Kevin C.、Mortimer Tatum D.、Shimuta Ken、Nakayama Shu-ichi、Hirabayashi Aki、Suzuki Masato、Jinnai Michio、Ohya Hitomi、Kuroki Toshiro、Watanabe Yuko、Yasuda Mitsuru、Deguchi Takashi、Eldholm Vegard、Harrison Odile B.、Maiden Martin C. J.、Grad Yonatan H.、Ohnishi Makoto
- Journal Title
  
  Genome Medicine
  
  Volume: 13 Issue: 1 Pages: 1-12
- DOI
  10.1186/s13073-021-00860-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07509, KAKENHI-PROJECT-18K17406, KAKENHI-PROJECT-18H02659
[Journal Article] Characterization of two Neisseria gonorrhoeae strains with high-level azithromycin resistance isolated in 2015 and 2018 in Japan2020
- Author(s)
  Shimuta Ken、Lee Kenichi、Yasuda Mitsuru、Furubayashi Keiichi、Uchida Chiaki、Nakayama Shu-ichi、Takahashi Hideyuki、Ohnishi Makoto
- Journal Title
  
  Sexually Transmitted Diseases
  
  Volume: Publish Ahead of Print Issue: 7 Pages: 1-5
- DOI
  10.1097/olq.0000000000001303
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09163, KAKENHI-PROJECT-19K07550, KAKENHI-PROJECT-18H02659
[Journal Article] A Real-Time PCR Assay for the Detection of a penA Mutation Associated with Ceftriaxone Resistance in Neisseria gonorrhoeae.2019
- Author(s)
  Shimuta K, Igawa G, Yasuda M, Deguchi T, Nakayama SI, Ohnishi M.
- Journal Title
  
  J Glob Antimicrob Resist
  
  Volume: in press Pages: 46-49
- DOI
  10.1016/j.jgar.2019.02.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11061, KAKENHI-PROJECT-18K09163, KAKENHI-PROJECT-18H02659
[Journal Article] A Loop-Mediated Isothermal Amplification Assay Targeting Neisseria Gonorrhoeae penA-60.0012019
- Author(s)
  Ken Shimuta, Shu-Ichi Nakayama, Hideyuki Takahashi, Makoto Ohnishi
- Journal Title
  
  Antimicrob Agents Chemother .
  
  Volume: 64 Issue: 1
- DOI
  10.1128/aac.01663-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07550, KAKENHI-PROJECT-18H02659, KAKENHI-PROJECT-16K11061
[Journal Article] Clonal expansion and spread of the ceftriaxone-resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates2019
- Author(s)
  203)Lee K, Nakayama SI, Osawa K, Yoshida H, Arakawa S, Furubayashi KI, Kameoka H, Shimuta K, Kawahata T, Unemo M, Ohnishi M.
- Journal Title
  
  J Antimicrob Chemother
  
  Volume: 74 Issue: 7 Pages: 1812-1819
- DOI
  10.1093/jac/dkz129
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02659, KAKENHI-PROJECT-18H03046, KAKENHI-PROJECT-16K11061
[Journal Article] Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae.2018
- Author(s)
  Igawa G, Yamagishi Y, Lee KI, Dorin M, Shimuta K, Suematsu H, Nakayama SI, Mikamo H, Unemo M, Ohnishi M
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 62 Issue: 3
- DOI
  10.1128/aac.02069-17
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11061
[Journal Article] Genomic surveillance of Neisseria gonorrhoeae to investigate the distribution and evolution of antimicrobial-resistance determinants and lineages2018
- Author(s)
  Yahara Koji、Nakayama Shu-ichi、Shimuta Ken、Lee Ken-ichi、Morita Masatomo、Kawahata Takuya、Kuroki Toshiro、Watanabe Yuko、Ohya Hitomi、Yasuda Mitsuru、Deguchi Takashi、Didelot Xavier、Ohnishi Makoto
- Journal Title
  
  Microbial Genomics
  
  Volume: 4 Issue: 8 Pages: 1-13
- DOI
  10.1099/mgen.0.000205
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11061, KAKENHI-PROJECT-18K09163, KAKENHI-PROJECT-18K09184, KAKENHI-PROJECT-18K17406, KAKENHI-PROJECT-18H02659, KAKENHI-PROJECT-18H03046
[Journal Article] Antimicrobial susceptibility of Haemophilus influenzae strains isolated from the urethra of men with acute urethritis and/or epididymitis.2017
- Author(s)
  Deguchi T, Ito S, Hatazaki K, Horie K, Yasuda M, Nakane K, Mizutani K, Tsuchiya T, Yokoi S, Hanaoka N, Shimuta K, Ohnishi M, Muratani T, Nakano M
- Journal Title
  
  J Infect Chemother
  
  Volume: 23 Issue: 11 Pages: 804-807
- DOI
  10.1016/j.jiac.2017.05.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11061
[Journal Article] Conjunctivitis Caused by a Strain of <i>Neisseria gonorrhoeae</i> That Was Less Susceptible to Ceftriaxone2017
- Author(s)
  Iwata A, Shimuta K, Ohnishi M
- Journal Title
  
  Intern. Med.
  
  Volume: 56 Issue: 11 Pages: 1443-1445
- DOI
  10.2169/internalmedicine.56.7656
- NAID
  130006857224
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11061
[Journal Article] Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities.2017
- Author(s)
  Ito S, Hatazaki K, Shimuta K, Kondo H, Mizutani K, Yasuda M, Nakane K, Tsuchiya T, Yokoi S, Nakano M, Ohinishi M, Deguchi T.
- Journal Title
  
  Sexually Transmitted Diseses
  
  Volume: 44 Issue: 4 Pages: 205-210
- DOI
  10.1097/olq.0000000000000573
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26462442, KAKENHI-PROJECT-16K11061
[Journal Article] New ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain with a novel mosaic penA gene isolated in Japan2016
- Author(s)
  Nakayama SI, Shimuta K, Furubayashi KI, Kawahata T, Unemo M, Ohnishi M
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 60 Issue: 7 Pages: 4339-4341
- DOI
  10.1128/aac.00504-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K11061
[Journal Article] Temporal and spatial expression patterns of Cdc25 phosphatase isoforms during early Xenopus development2011
- Author(s)
  Nakajo, N, Deno, Y, Ueno, H, Kenmochi, C, Shimuta, K, Sagata, N
- Journal Title
  
  International Journal of Developmental Biology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791535
[Journal Article] Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?-Detailed characterization of the first high-level ceftriaxone resistant strain.2011
- Author(s)
  Ohnishi, M, Golparian, D, Shimuta, K, Saika, T, Hoshina, S, Iwasaku, K, Nakayama, S, Kitawaki, J, Unemo, M
- Journal Title
  
  Antimicrob Agents Chemother (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791535
[Journal Article] Spread of a Chromosomal Cefixime-Resistant penA Gene among Different Neisseria gonorrhoeae Lineages2010
- Author(s)
  Ohnishi M, Watanabe Y, Ono E, Takahashi H, Oya H, Kuroki T, Shimuta K, Okazaki N, Nakayama S, Watanabe H
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 54 Pages: 1060-1067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791535
[Journal Article] Identification of TEM-135 β-Lactamase in Penicillinase-Producing Neisseria gonorrhoeae Strains in Japan.2010
- Author(s)
  Ohnishi, M, Ono, E, Shimuta, K, Watanabe, H, Okamura, N
- Journal Title
  
  Antimicrob Agents Chemother 54(7)
  
  Pages: 3021-3023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791535
[Journal Article] Spreading of a chromosomal cefixime resistant penA gene among different Neisseria gonorrhoeae lineages.2010
- Author(s)
  Ohnishi, M, Watanabe, Y, Ono, E, Takahashi, C, Oya, H, Kuroki, T, Shimuta, K, Okazaki, N, Nakayama, S, Watanabe, H
- Journal Title
  
  Antimicrob Agents Chemother 54(3)
  
  Pages: 1060-1067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791535
[Journal Article] Identification of TEM-135 β-Lactamase in Penicillinase-Producing Neisseria gonorrhoeae Strains in Japan2010
- Author(s)
  Ohnishi M, Ono E, shimuta k, Watanabe H, Okamura N
- Journal Title
  
  Antimicrobial Agents and Chemotherapy
  
  Volume: 54 Pages: 3021-3023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791535
[Presentation] SNPタイピングによるセフトリアキソン耐性淋菌株の保持するpenA 遺伝子のLAMP法による検出2020
- Author(s)
  志牟田健
- Organizer
  第12回LAMP研究会
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] 淋菌penA 60.001遺伝子のLAMP法による検出2019
- Author(s)
  志牟田　健、中山周一、高橋英之、大西真
- Organizer
  日本性感染症学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-18H02659
[Presentation] 淋菌pneA 60.001遺伝子のLAMP法による検出2019
- Author(s)
  志牟田健、中山周一、高橋英之、大西真
- Organizer
  日本性感染症学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] 2018年にわが国で分離された淋菌の薬剤感受性報告2019
- Author(s)
  安田満、志牟田健、中山周一、小林寅喆、大澤佳代、陣内理生、三宅啓文、浜砂良一、荒川創一、大西真
- Organizer
  日本性感染症学会第32回学術大会
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] CTRX耐性N. gonorrhoeaeおよびCTRX低感受性N. subflavaに対するpenA遺伝子解析2018
- Author(s)
  金坂伊須萌、山根夏枝、伊與田貴子、天野綾子、小山英明、松本　哲、勝瀬（金山）明子、志牟田健、大西　真、小林寅喆
- Organizer
  日本性感染症学会第31回学術大会
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] 2015～2017年にわが国で分離された淋菌の薬剤感受性報告2018
- Author(s)
  安田満、志牟田健、中山周一、小林寅喆、大澤佳代、陳内理生、三宅啓文、濵砂良一、荒川創一、大西　真
- Organizer
  日本性感染症学会第31回学術大会
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] 大阪府内において分離された淋菌株の薬剤感受性率の推移と多剤耐性の傾向2017
- Author(s)
  川畑拓也、古林敬一、亀岡　博、安本亮二、中山周一、志牟田健、大西　真
- Organizer
  日本性感染症学会
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] セフトリアキソン耐性淋菌特異的リアルタイムPCR系の構築2017
- Author(s)
  志牟田健、井川ジーン、中山周一、大西真
- Organizer
  日本性感染症学会
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] 種を超えた遺伝子伝播―耐性遺伝子プールの存在2017
- Author(s)
  志牟田健
- Organizer
  第66回日本感染症学会東日本地方学術集会、第64回日本化学療法学会東日本支部総会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] Characterization of azithromycin resistant Neisseria gonorrhoeae strains isolated in Kyoto and Osaka, Japan, 2010-20152016
- Author(s)
  Ken Shimuta, Shu-ichi Nakayama, Tomoko Morita-Ishihara, Makoto Ohnishi
- Organizer
  19th IUSTI Asia-Pacific Conference
- Place of Presentation
  Okayama
- Year and Date
  2016-12-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11061
[Presentation] 簡易的な淋菌のスクリーニング系の検討2010
- Author(s)
  志牟田健、中山周一、飛田収一、伊東三喜雄、藤原光文、大前利市、石川和弘、大西真
- Organizer
  日本性感染症学会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-21791535
[Presentation] 簡易的な淋菌のスクリーニング系の検討2010
- Author(s)
  志牟田健
- Organizer
  日本性感染症学会第23回学術大会
- Place of Presentation
  福岡市
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-21791535

1. OHNISHI Makoto (10233214)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. NAKAYAMA Shu-ichi (80280767)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. YAMAMOTO Shingo (80322741)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 泉福英信 (20250186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. DEGUCHI Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SUZUKI Masato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 高橋英之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 安田満

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

SHIMUTA KEN 志牟田 健

Shimuta Ken 志牟田 健

SHIMUTA Ken 志牟田 健

志牟 田健 シムタ ケン

Research Projects

Research Products

Co-Researchers

DETECTR法による淋菌の薬剤感受性判定法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

LAMP法による簡易的な淋菌の薬剤感受性判定を可能とするアッセイ系の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Origin of drug resistant gene of Neisseria gonorrhoeae.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Diversity of Neisseria gonorrhoeae strains in the host responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the cell cycle in infected culture cell of Neisseria gonorrhoeae.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポストゲノム時代に対応した歯周病リスク診断用ペプチドアレイの構築

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Model for evaluation of pathogenicity of extra-intestinal pathogenic Escherichia coli

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular characterization of <i>Neisseria gonorrhoeae</i> isolates collected through a national surveillance programme in Japan, 2013: evidence of the emergence of a ceftriaxone-resistant strain from a ceftriaxone-susceptible lineage2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of two Neisseria gonorrhoeae strains with high-level azithromycin resistance isolated in 2015 and 2018 in Japan2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Real-Time PCR Assay for the Detection of a penA Mutation Associated with Ceftriaxone Resistance in Neisseria gonorrhoeae.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Loop-Mediated Isothermal Amplification Assay Targeting Neisseria Gonorrhoeae penA-60.0012019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonal expansion and spread of the ceftriaxone-resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae.2018

SHIMUTA KEN 志牟田健

Shimuta Ken 志牟田健

SHIMUTA Ken 志牟田健

志牟田健シムタケン