THUMKEO Dean ＴｈｕｍｋｅｏＤｅａｎ

… Alternative Names

ＴｈｕｍｋｅｏＤｅａｎタムケオデイーン

Dean Thumkeo ディーンタムケオ

Less

Researcher Number	40372594
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 京都大学, 医学研究科, 特定准教授 2017: 京都大学, 医学(系)研究科(研究院), その他 2016: 京都大学, 医学研究科, 特定准教授 2015: 京都大学, 医学研究科, 助教 2013 – 2015: 京都大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator General pharmacology / Basic Section 48030:Pharmacology-related Except Principal Investigator Neurosurgery / Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator アクチン / T細胞 / mDia / Treg / 制御性T細胞 / 免疫抑制剤 / TCRシグナル / がん / 免疫抑制 / 腫瘍 … More / PGE2 / T細胞受容体シグナル / 皮質下 / formin / 細胞・組織 / 免疫学 / 薬理学 / 免疫寛容 / アクチン細胞骨格 / 低分子量G蛋白質 / F-actin … More Except Principal Investigator リプログラミング / iPS / エピゲノム / エピゲノム異常 / iPS細胞 / 転写ネットワーク / AT/RT / ｉＰＳ / RAD21 / SMARCB1 / INI-1 / ヒト人工多能性幹細胞 / 非定型奇形腫様ラブドイド腫瘍 / グリオーマ / 脳腫瘍 / 分化誘導 / ダイレクトリプログラミング / 低悪性度グリオーマ / 悪性グリオーマ / ウイルス治療 / 免疫誘導 / 腫瘍免疫 / 生体イメージング / ワクシニアウイルス / 悪性脳腫瘍 Less

Elucidation of the role and mechanism of action of prostaglandin E2 in cancer though the immune suppression activity of Treg cellsPrincipal Investigator
- Principal Investigator
  
  Thumkeo Dean
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyoto University
Elucidation of the molecular mechanism of T cell subcortical actin formation and its role in TCR signalingPrincipal Investigator
- Principal Investigator
  
  Thumkeo Dean
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyoto University
Epigenetic analysis and drug development with cell-reprogramming technology in atypical teratoid/rhabdoid tumor
- Principal Investigator
  
  Arakawa Yoshiki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kyoto University
Role of mDia, a polymerization factor, in Treg differentiationPrincipal Investigator
- Principal Investigator
  
  Thumkeo Dean
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Epigenomic analysis with reprogramming technology in lower grade glioma
- Principal Investigator
  
  Arakawa Yoshiki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Kyoto University
Analysis of TCR signaling dependent mDia activation molecular mechanismPrincipal Investigator
- Principal Investigator
  
  Thumkeo Dean
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University
Analysis of antitumor immunity induced by vaccinia virus with in vivo imaging
- Principal Investigator
  
  Arakawa Yoshiki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Kyoto University
Molecular mechanism of mDia function in T cell activationPrincipal Investigator
- Principal Investigator
  
  THUMKEO Dean
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General pharmacology
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner2024
- Author(s)
  Watabe Tetsuya、Yamahira Shinya、Takakura Kanako、Thumkeo Dean、Narumiya Shuh、Matsuda Michiyuki、Terai Kenta
- Journal Title
  
  eLife
  
  Volume: 12 Pages: 1-9
- DOI
  10.7554/elife.86727
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06356, KAKENHI-PROJECT-19H00993, KAKENHI-PROJECT-23K21377
[Journal Article] Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice2024
- Author(s)
  Akamine Takahiro、Terabayashi Takeshi、Sasaki Takako、Hayashi Riku、Abe Ichitaro、Hirayama Fumihiro、Nureki Shin‐ichi、Ikawa Masahito、Miyata Haruhiko、Tokunaga Akinori、Kobayashi Takashi、Hanada Katsuhiro、Thumkeo Dean、Narumiya Shuh、Ishizaki Toshimasa
- Journal Title
  
  FEBS Open Bio
  
  Volume: - Issue: 6 Pages: 906-921
- DOI
  10.1002/2211-5463.13802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08384, KAKENHI-PROJECT-23K06356, KAKENHI-PROJECT-22K16175
[Journal Article] Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response2023
- Author(s)
  Wongchang Thamrong、Pluangnooch Panwadee、Hongeng Suradej、Wongkajornsilp Adisak、Thumkeo Dean、Soontrapa Kitipong
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 7058-7058
- DOI
  10.1038/s41598-023-34211-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06356
[Journal Article] LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation2022
- Author(s)
  Kremer Kimberly N.、Buser Alan、Thumkeo Dean、Narumiya Shuh、Jacobelli Jordan、Pelanda Roberta、Torres Raul M.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 15
- DOI
  10.1073/pnas.2118816119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07287, KAKENHI-PROJECT-20H00498
[Journal Article] Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing2022
- Author(s)
  Siriwach Ratklao、Ngo Anh Quynh、Higuchi Makio、Arima Kentaro、Sakamoto Satoko、Watanabe Akira、Narumiya Shuh、Thumkeo Dean
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 4 Pages: 104130-104130
- DOI
  10.1016/j.isci.2022.104130
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00498, KAKENHI-PROJECT-20K07287
[Journal Article] An optimized protocol to identify keratinocyte subpopulations in vitro by single-cell RNA sequencing analysis.2022
- Author(s)
  Siriwach R, Ngo AQ, Narumiya S, Thumkeo D.
- Journal Title
  
  STAR Protoc.
  
  Volume: 3(4) Issue: 4 Pages: 101906-101906
- DOI
  10.1016/j.xpro.2022.101906
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00498, KAKENHI-PROJECT-20K07287
[Journal Article] PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment.2022
- Author(s)
  Thumkeo D, Punyawatthananukool S, Prasongtanakij S, Matsuura R, Arima K, Nie H, Yamamoto R, Aoyama N, Hamaguchi H, Sugahara S, Takeda S, Charoensawan V, Tanaka A, Sakaguchi S, Narumiya S.
- Journal Title
  
  Cell Reports
  
  Volume: 39(10) Issue: 10 Pages: 110914-110914
- DOI
  10.1016/j.celrep.2022.110914
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00498, KAKENHI-PROJECT-20K07287, KAKENHI-PROJECT-23K24181
[Journal Article] DIAPH1 mutations in sporadic moyamoya disease implicate impaired vascular cell actin remodeling in disease pathogenesis.2021
- Author(s)
  Kundishora AJ, Peters S, Pinard A, Duran D, Panchagnula S, Barak T, Miyagishima DF, Dong W, Dunbar A, Smith H, Ocken J, Nelson-Williams C, Haider S, Walker RL, Li B, Zhao H, Thumkeo D,その他29名
- Journal Title
  
  JAMA Neurology
  
  Volume: 未定
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07287
[Journal Article] Opening the door to better aspirin2021
- Author(s)
  Thumkeo D, Narumiya S
- Journal Title
  
  Structure
  
  Volume: 29 Issue: 3 Pages: 200-202
- DOI
  10.1016/j.str.2021.02.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07287
[Journal Article] mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.2020
- Author(s)
  Thumkeo, D., Katsura, Y., Nishimura, Y., Kanchanawong, P., Tohyama, K., Ishizaki, T., Kitajima, S., Takahashi, C., Hirata, T., Watanabe, N., Krummel, M. F., and Narumiya, S.
- Journal Title
  
  Sci. Adv.
  
  Volume: 6 Issue: 1 Pages: 2432-2432
- DOI
  10.1126/sciadv.aay2432
- NAID
  120006777011
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07621, KAKENHI-PROJECT-19K22555, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-17H03576, KAKENHI-PROJECT-17K08339, KAKENHI-PROJECT-17K08591, KAKENHI-PROJECT-19H01020, KAKENHI-PROJECT-20H03509
[Journal Article] Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction2020
- Author(s)
  Abe Ichitaro、Terabayashi Takeshi、Hanada Katsuhiro、Kondo Hidekazu、Teshima Yasushi、Ishii Yumi、Miyoshi Miho、Kira Shintaro、Saito Shotaro、Tsuchimochi Hirotsugu、Shirai Mikiyasu、Yufu Kunio、Arakane Motoki、Daa Tsutomu、Thumkeo Dean、Narumiya Shuh、Takahashi Naohiko、Ishizaki Toshimasa
- Journal Title
  
  Cardiovascular Research
  
  Volume: 117 Issue: 4 Pages: 1103-1117
- DOI
  10.1093/cvr/cvaa206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08776, KAKENHI-PROJECT-20K07287, KAKENHI-PROJECT-19H04490
[Journal Article] DAAM2 variants cause nephrotic syndrome via actin dysregulation2020
- Author(s)
  Schneider R, Deutsch K, Hoeprich GJ, Marquez J, Hermle T, Braun DA, Seltzsam S, Kitzler TM, Mao Y, Buerger F, Majmundar AJ, Onuchic-Whitford AC, Kolvenbach CM, Schierbaum L, Schneider S, Halawi AA, Nakayama M, Mann N, Connaughton DM, Klambt V, Wagner M, Riedhammer KM, Renders L, Katsura Y, Thumkeo D, その他8名
- Journal Title
  
  American Journal of Human Genetics
  
  Volume: 107 Issue: 6 Pages: 1113-1128
- DOI
  10.1016/j.ajhg.2020.11.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07287
[Journal Article] T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation.2019
- Author(s)
  Lee J, Aoki T, Thumkeo D, Siriwach R, Yao C, Narumiya S.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 143(2) Issue: 2 Pages: 631-643
- DOI
  10.1016/j.jaci.2018.05.036
- NAID
  120006557522
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-17K08591
[Journal Article] Rho Signaling Research: History, Current Status and Future Directions2018
- Author(s)
  Shuh Narumiya, Dean Thumkeo
- Journal Title
  
  FEBS Letter
  
  Volume: in press
- NAID
  120006491996
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08591
[Journal Article] mDia1/3 generate cortical F-actin meshwork in Sertoli cells that is continuous with contractile F-actin bundles and indispensable for spermatogenesis and male fertility.2018
- Author(s)
  S. Sakamoto, D. Thumkeo, H. Ohta, Z. Zhang, S.R. Huang, P. Kanchenawong, T. Fuu, S. Watanabe, K. Shimada, Y. Fujihara, S. Yoshida, M. Ikawa, N. Watanabe, M. Saitou and S. Narumiya
- Journal Title
  
  Plos Biology
  
  Volume: 16 Issue: 9 Pages: e2004874-e2004874
- DOI
  10.1371/journal.pbio.2004874
- NAID
  120006531249
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05551, KAKENHI-PROJECT-16H02507, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-15H05573, KAKENHI-PROJECT-17H06098, KAKENHI-PROJECT-17K08591
[Journal Article] LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis.2018
- Author(s)
  Sumitomo A, Siriwach R, Thumkeo D, Ito K, Nakagawa R, Tanaka N, Tanabe K, Watanabe A, Kishibe M, Ishida-Yamamoto A, Honda T, Kabashima K, Aoki J, Narumiya S.
- Journal Title
  
  J Invest Dermatol. 2018 Nov 14.
  
  Volume: pii: S0022-202X(18)32815-X. Issue: 5 Pages: 1010-1022
- DOI
  10.1016/j.jid.2018.10.034
- NAID
  120006630981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-17K08591
[Journal Article] Constitutive activation of DIA1 (DIAPH1) via C-terminal truncation causes human sensorineural hearing loss2016
- Author(s)
  Ueyama T, Ninoyu Y, Nishio S, Miyoshi T, Torii H, Nishimura K, Sugahara K, Sakata H, Thumkeo D, Sakaguchi H, Watanabe N, Usami S, Saito N, Kitajiri S
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 8 Pages: 1310-1324
- NAID
  120005850206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18986
[Journal Article] Physiological roles of Rho and Rho effectors in mammals2013
- Author(s)
  Thumkeo D, Watanabe S, Narumiya S
- Journal Title
  
  European Journal of Cell biology
  
  Volume: Vol.92, 10-11 Issue: 10-11 Pages: 303-315
- DOI
  10.1016/j.ejcb.2013.09.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04389, KAKENHI-PROJECT-23229003, KAKENHI-PROJECT-25860188
[Journal Article] Moesin Controls Clathrin-Mediated S1PR1 Internalization in T Cells.2013
- Author(s)
  Nomachi A, Yoshinaga M, Liu J, Kanchanawong P, Tohyama K, Thumkeo D, Watanabe T, Narumiya S, Hirata T.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 12 Pages: e82590-e82590
- DOI
  10.1371/journal.pone.0082590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229003, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111009, KAKENHI-PROJECT-25460588, KAKENHI-PROJECT-25860188
[Journal Article] EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDial and mDia3 in combination2013
- Author(s)
  Yosuke Toyoda, Ryota Shinohara, Dean Thumkeo, Hiroshi Kamijo, Hiroshi Nishimaru, Hiroyuki Hioki, Takeshi Kaneko, Toshimasa Ishizaki, Tomoyuki Fnruyashiki and Shuh Narumiva
- Journal Title
  
  Genes to Cells
  
  Volume: 18 Issue: 10 Pages: 873-885
- DOI
  10.1111/gtc.12081
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J04246, KAKENHI-PROJECT-23229003, KAKENHI-PROJECT-23500460, KAKENHI-PROJECT-24500408, KAKENHI-PROJECT-24689015, KAKENHI-PUBLICLY-25116517, KAKENHI-PUBLICLY-25116715, KAKENHI-PUBLICLY-25121714, KAKENHI-PUBLICLY-25123709, KAKENHI-PROJECT-25430109, KAKENHI-PROJECT-25860188
[Presentation] マウス肺がんモデルにおける腫瘍免疫微小環境の解明 -PGE2シグナル伝達系の役割を例に-2024
- Author(s)
  タムケオ　ディーン
- Organizer
  金沢大学がん進展制御研究所共同利用・共同研究拠点研究成果報告会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06356
[Presentation] がん免疫回避におけるプロスタグランジンE2-EP2/4シグナルの役割解明2023
- Author(s)
  Dean Thumkeo, Siwakorn Punyawatthananukool, Shuh Narumiya.
- Organizer
  第96回日本生化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K06356
[Presentation] Elucidation of the role of PGE2-EP2/4 pathway in cancer immunity utilizing scRNA-seq technology2022
- Author(s)
  Dean Thumkeo, Siwakorn Punyawatthananukool, Varodom Charoensawan, Shuh Narumiya
- Organizer
  The Human Cell Atlas 2022 Asia meeting, Bangkok, Thailand, Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] Inhibition of PGE2-EP2/EP4 signaling elicits anti-tumor immunity through the suppression of mregDC-Treg axis in inflammatory tumor microenvironment2022
- Author(s)
  Dean Thumkeo, Siwakorn Punyawatthananukool, Shuh Narumiya
- Organizer
  第96回日本薬理学会年会,　横浜、シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] Activation of regulatory T cells through PGE2-EP4 signaling2022
- Author(s)
  Ryuma Matsuura, Dean Thumkeo, Shuh Narumiya
- Organizer
  第96回日本薬理学会年会,　横浜、口頭発表
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] Open up the next generation pharmacology with scRNA-seq technology ~elucidation of the role of PGE2-EP2/4 pathway in cancer immunity as an example~2022
- Author(s)
  Dean Thumkeo
- Organizer
  The 24th Japan-Korea Joint Seminar on Pharmacology, Yokohama, Japan (Symposium)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] PGE2-EP2/EP4 signaling mediates immunosuppression in tumor microenvironment through the facilitation of mregDC-Treg axis2021
- Author(s)
  Thumkeo Dean, 成宮周
- Organizer
  第50回日本免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] 制御性T細胞に対するプロスタグランジンE2 の作用および分子制御機構の解明2021
- Author(s)
  松浦竜真、Thumkeo Dean、成宮周
- Organizer
  第140回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] Single cell RNA sequencing identifies a novel LPA-induced THBS1-positive keratinocyte subpopulation that is involved in wound healing2020
- Author(s)
  Anh Quynh Ngo, Ratklao Siriwach, Dean Thumkeo, Shuh Narumiya
- Organizer
  第138回日本薬理学会近畿支部会
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] New compounds for atopic dermatitis promote selective AHR-induced Filaggrin transcription in NHEK cells2020
- Author(s)
  Makio Higuchi, Dean Thumkeo, Shuh Narumiya
- Organizer
  第137回日本薬理学会近畿支部会
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] Molecular mechanism of the formin proteins, mDia1/3, in TCR signaling2020
- Author(s)
  Dean Thumkeo
- Organizer
  第72回日本細胞生物学会
- Data Source
  KAKENHI-PROJECT-20K07287
[Presentation] Critical role of formin-dependent cortical F-actin remodeling in TCR signaling2019
- Author(s)
  桂義親、Thumkeo Dean, 成宮周
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] 生体内におけるアクチン重合因子mDiaの生理的機能の解明～精子形成及びT細胞活性化を例に～2019
- Author(s)
  タムケオ　ディーン
- Organizer
  大分大学医学部セミナー
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] mDia1/3 facilitate Lat phosphorylation by Zap70 via the spatiotemporal control of F-actin polymerization at the immune synapse2019
- Author(s)
  Dean Thumkeo, Yoshichika Katsura, Yukako Nishimura, Pakorn Kanchanawong, Naoki Watanabe, Matthew F. Krummel, Shuh Narumiya
- Organizer
  ASCB EMBO 2019 meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] LPA induces keratinocyte differentiation and promote skin barrier function through the LPAR1/LPRA5-RHO-ROCK-SRF axis 2019
- Author(s)
  Dean Thumkeo, Shuh Narumiya
- Organizer
  The 60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] リゾホスファチジン酸(LPA)によるヒト表皮細胞の分化誘導及び皮膚バリア機能の促進2018
- Author(s)
  田邊滉平、Thumkeo Dean, 成宮周
- Organizer
  第134回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] ヒト表皮細胞のバリア機能におけるリゾホスファチジン酸(LPA)の役割解明2018
- Author(s)
  田邊滉平、Thumkeo Dean, Siriwach Ratklao, 青木淳賢、成宮周
- Organizer
  第133回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] Indispensable role of formin-dependent cortical F-actin remodeling in TCR signaling2018
- Author(s)
  Dean Thumkeo, Matthew Krummel, Shuh Narumiya
- Organizer
  EMBO Workshop “Lymphocyte antigen receptor signaling”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] Lysophosphatidic acid facilitates human keratinocyte differentiation through the LPAR1/LPAR5-Rho-ROCK-SRF axis and promotes skin barrier function2018
- Author(s)
  Dean Thumkeo, Shuh Narumiya
- Organizer
  第3回京都皮膚基礎研究会、京都
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] Roles of prostaglandins E2-EP2 signaling in colitis-associated cancer model2018
- Author(s)
  Dean Thumkeo, Xiaojun Ma, Jinju Lee, Shuh Narumiya
- Organizer
  第45回内藤カンファレンス “Immunological and Molecular Bases for Cancer Immunotherapy”
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] Cortical F-actin meshwork in Sertoli cells is a structure in continuous with contractile F-actin bundles and dependent on formins activity2018
- Author(s)
  Dean Thumkeo
- Organizer
  生体運動研究合同班会議、東京
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] IL-23 generates pathogenic Th17 cells by trigerring T cell-intrinsic prostaglandin E2-EP2EP4 signaling2018
- Author(s)
  Jinju Lee, Dean Thumkeo, Tomohiro Aoki, Chengcan Yao, Shuh Narumiya
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] T細胞受容体シグナル伝達におけるforminの機能解析2018
- Author(s)
  Yoshichika Katsura, Dean Thumkeo, Shuh Narumiya
- Organizer
  第138回日本薬理学会関東部会、東京
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] アクチン制御タンパクforminのT細胞受容体シグナル伝達における機能解析2018
- Author(s)
  桂義親、Thumkeo Dean, 成宮周
- Organizer
  第133回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] PGE2-EP2/EP4シグナリングによるTh17細胞の増殖制御機構とその病理に対する寄与2017
- Author(s)
  Jinju Lee, Tomohiro Aoki, Dean Thumkeo, Shuh Narumiya
- Organizer
  第132回日本薬理学会近畿部会, 大阪
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] 目の発生におけるmDiaの機能解析2017
- Author(s)
  Thumkeo D, Sakamoto S, Fu T, Narumiya S
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] 精子形成におけるmDia1/3の機能解析2017
- Author(s)
  Fu T, Sakamoto S, Thumkeo D, Narumiya S
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] TCRシグナル伝達におけるformin依存的なアクチンの機能解析2017
- Author(s)
  Yoshichika Katsura, Dean Thumkeo, Shuh Narumiya
- Organizer
  第132回日本薬理学会近畿部会, 大阪
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] 免疫シナプスにおけるmDia1/3依存的なF-actinの機能解析2017
- Author(s)
  Katsura Y, Thumkeo D, Narumiya S
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] グリオーマにおけるVasohibin-1の発現解析2017
- Author(s)
  Yokogawa R, Thumkeo D, Arakawa Y
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] Lysophosphatidic acid induces Filaggrin expression and promotes skin barrier function in human keratinocyte2017
- Author(s)
  Ratklao Siriwach, Akiko Sumitomo, Kentaro Ito, Kohei Tanabe, Dean Thumkeo, Shuh Narumiya
- Organizer
  第132回日本薬理学会近畿部会, 大阪
- Data Source
  KAKENHI-PROJECT-17K08591
[Presentation] Regulation of cortical F-actin meshwork architecture in Sertoli cell by mDia1/32016
- Author(s)
  Dean Thumkeo, Satoko Sakamoto, Shuh Narumiya
- Organizer
  生体運動合同班会議
- Place of Presentation
  京都
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] Indispensable role of mDia1/3 in sperm morphogenesis through the remodeling of Sertoli cell meshwork F-actin2016
- Author(s)
  Dean Thumkeo, Satoko Sakamoto, Shuh Narumiya
- Organizer
  第59回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] Roles of mDia1/3 in neuroepithelium integrity and neuroblast migration2015
- Author(s)
  Dean Thumkeo, Ryota Shinohara, Shuh Narumiya
- Organizer
  The 56th Annual Meeting of the American Society for Cell Biology
- Place of Presentation
  サンディエゴ、米国
- Year and Date
  2015-12-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] Role of mDia in spermatogenesis2015
- Author(s)
  Satoko Sakamoto, Dean Thumkeo, Masahito Ikawa, Yoshitaka Fujiwara, Hiroshi Ohta, Sadanori Watanabe, Shuh Narumiya
- Organizer
  第67回日本細胞生物学会
- Place of Presentation
  東京
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] T cell cortical F-actin is mediated by mDia and critical for TCR signaling2015
- Author(s)
  Kiyoshi Tohyama, Dean Thumkeo, Shuh Narumiya
- Organizer
  The 88th Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  名古屋
- Year and Date
  2015-03-19
- Data Source
  KAKENHI-PROJECT-25860188
[Presentation] mDia1/3-mediated cortical F-actin assembly is required for T cell receptor signaling2015
- Author(s)
  Dean Thumkeo, Kiyoshi Tohyama, Pakorn Kanchanawong, Shuh Narumiya
- Organizer
  第67回日本細胞生物学会
- Place of Presentation
  東京
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K18986
[Presentation] Formin family actin nucleators, mDia1 and mDia3, mediate TCR microcluster dynamics and signaling critical for positive selection of thymocytes2015
- Author(s)
  Dean Thumkeo, Akira Nomachi, Kiyoshi Tohyama, Shuh Narumiya
- Organizer
  The 88th Annual Meeting of the Japanese Pharmacological Society
- Place of Presentation
  名古屋
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PROJECT-25860188
[Presentation] The formin protein mDia is indispensible for TCR signaling dependent T cell development through actin nucleation activity.2014
- Author(s)
  Dean Thumkeo, Akira Nomachi, Kiyoshi Tohyama, Shuh Narumiya
- Organizer
  The 66th Annual Meeting of the Japanese Society for Cell Biology
- Place of Presentation
  奈良
- Year and Date
  2014-06-11
- Data Source
  KAKENHI-PROJECT-25860188
[Presentation] 胸腺T細胞の分化におけるアクチン重合因子mDia1/3の機能解析2014
- Author(s)
  タムケオ　ディーン、野町昭、通山潔、平田多佳子、石崎敏理、成宮周
- Organizer
  第87回　日本薬理学会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-25860188
[Presentation] T細胞活性化におけるmDiaの機能解析2014
- Author(s)
  通山潔、タムケオ　ディーン、成宮周
- Organizer
  第87回　日本薬理学会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-25860188
[Presentation] Immunotherapy for cancer: challenges and approach2013
- Author(s)
  Dean Thumkeo, Yoshiki Arakawa
- Organizer
  International Conference in Medicine and Public Health 2013
- Place of Presentation
  Siriraj Hospital, Bangkok, Thailand
- Invited
- Data Source
  KAKENHI-PROJECT-25860188
[Presentation] Roles of mDia in TCR signaling and its potential as a novel target for immunoregulation drug2013
- Author(s)
  Dean Thumkeo, Shuh Narumiya
- Organizer
  International Conference in Medicine and Public Health 2013
- Place of Presentation
  Siriraj Hospital, Bangkok, Thailand
- Invited
- Data Source
  KAKENHI-PROJECT-25860188
[Presentation] Physiological roles of mDia, a Rho effector and actin nucleator, in mammals2013
- Author(s)
  Dean Thumkeo, Sadanori Watanabe, Shuh Narumiya
- Organizer
  第86回　日本生化学会
- Place of Presentation
  パシフィコ横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25860188
[Presentation] Indispensable role of formin family actin nucleator, mDia1 and mDia3, in TCR microcluster dynamics and signaling critical for positive selection of thymocytes
- Author(s)
  Dean Thumkeo, Peter Beemiller, Akira Nomachi, Matthew F. Krummel, Shuh Narumiya
- Organizer
  The 37th Naito Conference “Bioimaging-a paradigm shift for the life science”
- Place of Presentation
  ニセコ、北海道
- Year and Date
  2014-07-15 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25860188

1. Arakawa Yoshiki (20378649)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 平田英周 (40761937)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. Yokogawa Ryuta

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Terada Yukinori

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. Fukui Nobuyuki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Liu Bin

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. Matsuda Michiyuki (10199812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yamada Yasuhiro (70313872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Murata Daiki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Fujimoto Ko-ichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Matsui Yasuzumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Makino Yasuhide

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Sumiyoshi Sosuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Hattori Etsuko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TERABAYASHI Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 吉田松生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 成宮周

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
18. 平田多佳子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 石崎敏理

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 花田克浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

THUMKEO Dean Ｔｈｕｍｋｅｏ Ｄｅａｎ

Ｔｈｕｍｋｅｏ Ｄｅａｎ タムケオ デイーン

Dean Thumkeo ディーン タムケオ

Research Projects

Research Products

Co-Researchers

Elucidation of the role and mechanism of action of prostaglandin E2 in cancer though the immune suppression activity of Treg cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism of T cell subcortical actin formation and its role in TCR signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic analysis and drug development with cell-reprogramming technology in atypical teratoid/rhabdoid tumor

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of mDia, a polymerization factor, in Treg differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epigenomic analysis with reprogramming technology in lower grade glioma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of TCR signaling dependent mDia activation molecular mechanismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of antitumor immunity induced by vaccinia virus with in vivo imaging

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of mDia function in T cell activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Single-cell RNA sequencing identifies a migratory keratinocyte subpopulation expressing THBS1 in epidermal wound healing2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An optimized protocol to identify keratinocyte subpopulations in vitro by single-cell RNA sequencing analysis.2022

THUMKEO Dean ＴｈｕｍｋｅｏＤｅａｎ

ＴｈｕｍｋｅｏＤｅａｎタムケオデイーン

Dean Thumkeo ディーンタムケオ