Fujimoto Kei 藤本啓

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FUJIMOTO Kei 藤本啓

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Researcher Number	40372974
Other IDs
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2015 – 2021: 東京慈恵会医科大学, 医学部, 准教授 2012 – 2014: 東京慈恵会医科大学, 医学部, 講師 2011: 東京慈恵会医科大学, 医学部, 助教 2007: Jikei University School of Medicine, Department of medicine, Clinical Associate 2005 – 2006: 東京慈恵会医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Metabolomics
Keywords	Principal Investigator MODY / PKCδ / グルカゴン / 膵α細胞 / pdx1 / pkcdelta / apoptosis / Palmitate / Pkcdelta / Apoptosis … More / diabetes / beta cell mass / glucolipotoxicity / beta cell death / Diabetes / Beta cell mass / Glucolipotoxicity / Beta cell death / β細胞容積 / アポトーシス / β細胞死 / 膵β細胞容積 / 糖質代謝異常 / エネルギー / 膵島細胞 / 再生医療 / インスリン分泌 … More Except Principal Investigator インスリン / adenoassociated virus / endocrine pancreas / cyclin-deuendent kinase / cvclin / insulin / aene therapy / cell cycle / reaenerative medicine / トランスレーショナルリサーチ / 再生医学 / ウイルス / 遺伝子 / 膵臓 / ベータ細胞 / 増殖 / 糖尿病 / アデノ随伴ウイルス / 膵内分泌 / サイクリン依存性キナーゼ / サイクリン / 遺伝子治療 / 細胞周期 / 再生医療 / pancreatic islet / 培養 / シュワン細胞 / 神経堤 / 酸化ストレス / ゲノム編集 / gap junction / ブドウ糖応答性インスリン分泌 / Schwann細胞 / 膵島三次元構造 / 恒常性の破綻 / 自己組織化 / ブドウ糖応答性 / インスリン分泌 / 三次元培養法 / インスリノーマ / 膵島障害 Less

Mechanism of PKC delta-dependent glucagon secretion in pancreatic alpha cellsPrincipal Investigator
- Principal Investigator
  
  Fujimoto Kei
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Jikei University School of Medicine
Function-structure relationship; role of the islet Schwann cells
- Principal Investigator
  
  Sasaki Takashi
- Project Period (FY)
  2014 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jikei University School of Medicine
Glucolipotoxicity-induced PKCdelta dependent pancreatic beta cell deathPrincipal Investigator
- Principal Investigator
  
  Fujimoto Kei
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jikei University School of Medicine
Novel protein Nix regulates pancreatic beta cell massvia PKCδPrincipal Investigator
- Principal Investigator
  
  FUJIMOTO Kei
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jikei University School of Medicine
オン・デマンド増殖可能な遺伝子改変動物由来膵島細胞の樹立Principal Investigator
- Principal Investigator
  
  藤本啓
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Jikei University School of Medicine
Inhibition of injury and promotion of regeneration in pancreatic islets of diabetes mellitus the by molecular intervention
- Principal Investigator
  
  SASAKI Takashi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Jikei University School of Medicine

All 2022 2021 2017 2016 2015 2012 2011 2007 2006 Other

All Journal Article Presentation Book

[Book] 日本医事新報 β細胞マス温存をめざした治療 [インクレチン関連薬とインスリンの併用が有効]2016
- Author(s)
  藤本啓
- Total Pages
  1
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-25461366
[Journal Article] Protein Kinase C (Pkc)-δ Mediates Arginine-Induced Glucagon Secretion in Pancreatic α-Cells2022
- Author(s)
  Honzawa Norikiyo、Fujimoto Kei、Kobayashi Masaki、Kohno Daisuke、Kikuchi Osamu、Yokota-Hashimoto Hiromi、Wada Eri、Ikeuchi Yuichi、Tabei Yoko、Dorn Gerald W.、Utsunomiya Kazunori、Nishimura Rimei、Kitamura Tadahiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 7 Pages: 4003-4003
- DOI
  10.3390/ijms23074003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08491
[Journal Article] Temporal and Spatial Cellular Distribution of Neural Crest Derivatives and Alpha Cells during Islet Development2012
- Author(s)
  Shimada K
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 45 Issue: 1 Pages: 65-75
- DOI
  10.1267/ahc.11052
- NAID
  130001854316
- ISSN
  0044-5991, 1347-5800
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791044
[Journal Article] Establishment of a novel transplantation method for murine islets embedded in reconstituted basement membrane matrix2012
- Author(s)
  Hiki Y, Sasaki T, Shimada K, Fujimoto K, Nemoto M, Utsunomiya K
- Journal Title
  
  Jikeikai Med J
  
  Volume: 127 Pages: 49-61
- URL
  http://hdl.handle.net/10328/7413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791044
[Journal Article] レジオネラ肺炎とDKAを契機にMELASの症状が顕在化したミトコンドリア糖尿病の1例2011
- Author(s)
  山城健二, 南雲左江, 池田梨奈, 藤本啓, 比企能人, 五條淳, 斉藤隆俊, 宇都宮一典, 佐々木敬
- Journal Title
  
  糖尿病
  
  Volume: 54
- Data Source
  KAKENHI-PROJECT-23791044
[Journal Article] Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes:a case control study with multi-slice computed tomography2007
- Author(s)
  根本昌実、佐々木敬、藤本啓、比企能人, ほか
- Journal Title
  
  Cardiovascular diabetology 6
  
  Pages: 23-29
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590948
[Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β (TCF2) Mutation2007
- Author(s)
  Fujimoto, K., Sasaki, T., et. al.
- Journal Title
  
  Endocrine Journal 54
  
  Pages: 757-764
- NAID
  10020092977
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590948
[Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β (Tcf2) Mutation2007
- Author(s)
  Fujimoto K, Sasaki T, Hiki Y, Nemoto M, Utsunomiya Y, Yokoo T, Nakai N, Ohashi T, Hosoya T, Eto Y, Tajima N.
- Journal Title
  
  Endocrine Journal (In press)
- NAID
  10020092977
- Data Source
  KAKENHI-PROJECT-18790626
[Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β (TCF2) Mutation2007
- Author(s)
  藤本啓、佐々木敬、根本昌実、比企能人, ほか
- Journal Title
  
  Endocr J 54
  
  Pages: 757-764
- NAID
  10020092977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590948
[Journal Article] Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography.2007
- Author(s)
  Nemoto M, Nishimura R, Sasaki T, Hiki Y, Miyashita Y, Nishioka M, Fujimoto K, Sakuma T, Ohashi T, Fukuda K, Eto Y, Tajima N.
- Journal Title
  
  Cardiovasc Diabetol. (In press)
- Data Source
  KAKENHI-PROJECT-18790626
[Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β(TCF2)Mutation2007
- Author(s)
  藤本啓、佐々木敬、根本昌実、比企能人, ほか
- Journal Title
  
  Endocr J 54
  
  Pages: 757-764
- NAID
  10020092977
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17590948
[Presentation] 膵α細胞のアルギニン応答性グルカゴン分泌にPkcδが関与する2022
- Author(s)
  本澤訓聖、藤本啓、小林雅樹、西村理明、北村忠弘
- Organizer
  第65回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-18K08491
[Presentation] 膵α細胞からのグルカゴン分泌にPKCδが関与する2021
- Author(s)
  本澤訓聖、藤本啓、小林雅樹、西村理明、北村忠弘
- Organizer
  第94回日本内分泌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08491
[Presentation] 日本人1型糖尿病家系における非HLA遺伝子の連鎖と両親からの遺伝様式の検討2017
- Author(s)
  根本昌実, 溝渕杏子, 佐々木敬, 藤本啓, 比企能人, 大橋十也, 宇都宮一典
- Organizer
  第21回日本適応医学会学術集会（12月、東京）
- Data Source
  KAKENHI-PROJECT-26461346
[Presentation] 膵α細胞におけるPKCδ依存性グルカゴン分泌機序の解明2016
- Author(s)
  塩崎正嗣, 藤本啓, 佐々木敬, 宇都宮一典
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-25461366
[Presentation] PKCdelta is a key regulator of palmitate-induced beta cell death2015
- Author(s)
  Masatsugu Shiozaki, Kei Fujimoto, Takashi Sasaki, Kiyotsugu Yoshida, Kazunori Utsunomiya
- Organizer
  51st European association for the study of Diabetes Annual Meeting
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-09-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461366
[Presentation] 脂肪毒性はPKCδを介して膵β細胞死を誘導する2015
- Author(s)
  塩崎　正嗣、藤本　啓、宇都宮　一典
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  グランプス・セント・ヴァレンタイン(山口県下関市)
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-25461366
[Presentation] PKCdelta is a key regulator of palmitate-induced beta cell death.2015
- Author(s)
  Masatsugu Shiozaki ,Kei Fujimoto, Takashi Sasaki, Yoshida K, Kazunori Utsunomiya
- Organizer
  51st European Association for the Study of Diabetes (EASD) annual meeting
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461346
[Presentation] 2型糖尿病経過中に劇症 1 型糖尿病様の発症様式を呈し重度の代謝失調を来した 1 例2012
- Author(s)
  川浪大治, 好川有希子, 井出華子, 田中厚子, 坂本昌也, 藤本啓, 宇都宮一典
- Organizer
  593回日本内科学会関東地方会
- Place of Presentation
  東京
- Year and Date
  2012-12-08
- Data Source
  KAKENHI-PROJECT-23791044
[Presentation] Investigation of Hypoglycemia, Hormone Response and Mutation in a Compound Heterozygote for FBP1 Fructose-1,6-bisphatase2012
- Author(s)
  Fujimoto K, Nakamura A,Mori Y, Sasaki T, Haruyama Y, Shimada K, Suzuki H, Okabe M, Yokoyama J, Utsunomiya K
- Organizer
  9th IDF-WPR / 4th AASD
- Place of Presentation
  京都
- Year and Date
  2012-11-26
- Data Source
  KAKENHI-PROJECT-23791044
[Presentation] 岡部正隆神経堤由来細胞と膵内分泌細胞の膵島形成過程における分布 α細胞と神経堤由来細胞の関係性2011
- Author(s)
  嶋田耕育, 比企能人, 藤本啓, 根本昌実, 佐々木敬
- Organizer
  第128回成医会総会
- Place of Presentation
  東京
- Year and Date
  2011-11-15
- Data Source
  KAKENHI-PROJECT-23791044
[Presentation] PKCdelta induces pancreatic beta cell death in a Nix-dependent manner2011
- Author(s)
  Fujimoto K, Sasaki T, Utsunomiya K, Dorn GW, Polonsky KS
- Organizer
  第71回アメリカ糖尿病学会
- Place of Presentation
  サンディエゴ
- Data Source
  KAKENHI-PROJECT-23791044
[Presentation] PKCδは新規タンパクNix依存性に膵β細胞死を誘導する2011
- Author(s)
  藤本啓, 佐々木敬, Polonsky Kenneth, 宇都宮一典
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-23791044
[Presentation] In vivo gene delivery by pancreatic direct injection of rAAV8 vector is efficient to the injured islets2007
- Author(s)
  比企能人、佐々木敬、根本昌実、藤本啓, ほか
- Organizer
  第67回米国糖尿病学会
- Place of Presentation
  Chicago,IL,USA
- Year and Date
  2007-06-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590948
[Presentation] Genetic association of Pro197Leu allele at GPX-1 gene to coronary artery calcification suggests importance of shifted redox balance for development of atherosclerosis in diabetes2006
- Author(s)
  根本昌実、佐々木敬、藤本啓、比企能人, ほか
- Organizer
  第42回ヨーロッパ糖尿病学会
- Place of Presentation
  Copenhagen,Denmark
- Year and Date
  2006-09-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590948
[Presentation] PKCδ活性と発現の抑制は糖脂肪毒性による膵β細胞死を抑制する
- Author(s)
  塩崎　正嗣、藤本　啓、宇都宮　一典
- Organizer
  第18回適応医学会学術集会
- Place of Presentation
  一橋大学一橋講堂
- Year and Date
  2014-06-22 – 2014-06-23
- Data Source
  KAKENHI-PROJECT-25461366
[Presentation] 遊離脂肪酸はPKCδ依存性に膵β細胞死を誘導する
- Author(s)
  塩崎　正嗣、藤本　啓、宇都宮　一典
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  グランプス・セント・ヴァレンタイン
- Year and Date
  2015-05-21 – 2015-05-24
- Data Source
  KAKENHI-PROJECT-25461366
[Presentation] 糖脂肪毒性による膵β細胞死にはPKCδが関与する
- Author(s)
  塩崎正嗣、藤本啓、佐々木敬、宇都宮一典
- Organizer
  第111回日本内科学会講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461366
[Presentation] 遊離脂肪酸はPKCδを介して膵β細胞死を誘導する
- Author(s)
  塩崎　正嗣、藤本　啓、宇都宮　一典
- Organizer
  第29回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  京都大学医学部　芝蘭会館
- Year and Date
  2015-02-13 – 2015-02-14
- Data Source
  KAKENHI-PROJECT-25461366
[Presentation] 糖脂肪毒性による膵β細胞死にはPKCδが関与する
- Author(s)
  塩崎　正嗣、藤本　啓、佐々木　敬、宇都宮　一典
- Organizer
  第111回日本内科学会講演会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2014-04-11 – 2014-04-13
- Data Source
  KAKENHI-PROJECT-25461366

1. Sasaki Takashi (90205849)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. NEMOTO Masami (10281396)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. Kouno Midori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Yoshizawa Yukio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Fujimoto Kei 藤本 啓

FUJIMOTO Kei 藤本 啓

Research Projects

Research Products

Co-Researchers

Mechanism of PKC delta-dependent glucagon secretion in pancreatic alpha cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Function-structure relationship; role of the islet Schwann cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Glucolipotoxicity-induced PKCdelta dependent pancreatic beta cell deathPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel protein Nix regulates pancreatic beta cell massvia PKCδPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

オン・デマンド増殖可能な遺伝子改変動物由来膵島細胞の樹立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Inhibition of injury and promotion of regeneration in pancreatic islets of diabetes mellitus the by molecular intervention

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 日本医事新報 β細胞マス温存をめざした治療 [インクレチン関連薬とインスリンの併用が有効]2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Protein Kinase C (Pkc)-δ Mediates Arginine-Induced Glucagon Secretion in Pancreatic α-Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Temporal and Spatial Cellular Distribution of Neural Crest Derivatives and Alpha Cells during Islet Development2012

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Establishment of a novel transplantation method for murine islets embedded in reconstituted basement membrane matrix2012

Author(s)

Journal Title

URL

Data Source

[Journal Article] レジオネラ肺炎とDKAを契機にMELASの症状が顕在化したミトコンドリア糖尿病の1例2011

Author(s)

Journal Title

Data Source

[Journal Article] Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes:a case control study with multi-slice computed tomography2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β (TCF2) Mutation2007

Author(s)

Journal Title

NAID

Description

Data Source

[Journal Article] In vitro and Pathological Investigations of MODY5 with the R276X-HNF1β (Tcf2) Mutation2007

Fujimoto Kei 藤本啓

FUJIMOTO Kei 藤本啓

[Presentation] 膵α細胞におけるPKCδ依存性グルカゴン分泌機序の解明2016

[Presentation] 岡部正隆神経堤由来細胞と膵内分泌細胞の膵島形成過程における分布 α細胞と神経堤由来細胞の関係性2011