KUBODERA Takayuki 久保寺隆行

Researcher Number	40376801
Affiliation (based on the past Project Information) *help	2009: Tokyo Medical and Dental University, 医学部・附属病院, 医員 2009: Tokyo Medical and Dental University, 医学部附属病院, 医員 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, メディカルフェロー 2007: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, COE拠点形成特別研究員 2006: 東京医科歯科大学, 大学院医歯学総合研究科, COE拠点形成特別研究員 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, COE拠点形成特別研究員
Review Section/Research Field	Principal Investigator Neurology
Keywords	Principal Investigator SOD1 / 遺伝子治療 / siRNA / AAV / トランスジェニックマウス / ALS / AIS / FAP / 小脳 / RNA毒性 … More / PKR / ポリグルタミン病 / RNAi / Machado-Joseph病 Less

In Vivo Application of an RNAi Strategy for the Selective Suppression of a Mutant AllelePrincipal Investigator
- Principal Investigator
  
  KUBODERA Takayuki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
新規siRNAデザインによるサルを用いた家族性アミロイドポリニューロパチーの治療Principal Investigator
- Principal Investigator
  
  久保寺隆行
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
いかなる変異に対しても特異的な新規RNA干渉法のin vivoでの有効性の検討Principal Investigator
- Principal Investigator
  
  久保寺隆行
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University
ポリグルタミン病のCAGリピートは2本鎖様なって毒性をもつPrincipal Investigator
- Principal Investigator
  
  久保寺隆行
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical and Dental University

All 2009 2008 2007 2005

All Journal Article Presentation

[Journal Article] Silencing efficiency differs among tissues and endogeneous microRNA pathway is preserved in short hairpin RNA transgenic mice2009
- Author(s)
  sasaguri H, Mitani T, Anzai M, Kubodera T, Saito Y, Yamada H, Mizusawa H, Yokota T
- Journal Title
  
  FEBS Letters 583
  
  Pages: 213-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790610
[Journal Article] Silencing efficiency differs among tissues and endogeneous microRNA pathway is preserved in short hairpin RNA transgenic mice2009
- Author(s)
  Sasaguri H, Mitani T, Anzai M, Kubodera T, Saito Y, Yamada H, Mizusawa H, Yokota T
- Journal Title
  
  FEBS Letters 583
  
  Pages: 213-218
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790610
[Journal Article] Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol2008
- Author(s)
  Kazutaka Nishina, Toshinori Unno, Yoshitaka Uno, Takayuki Kubodera, Tadashi Kanouchi, Hidehiro Mizusawa Takanori Yokota
- Journal Title
  
  Molecular Therapy 16
  
  Pages: 734-740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659222
[Journal Article] ALSの遺伝子治療2008
- Author(s)
  久保寺隆行、横田隆徳、水澤英洋
- Journal Title
  
  Clinical Neuroscience 26
  
  Pages: 337-339
- Data Source
  KAKENHI-PROJECT-19659222
[Journal Article] ウイルスベクターを用いたshRNAによる遺伝子治療の現状と問題点2008
- Author(s)
  久保寺隆行, 横田隆徳
- Journal Title
  
  Antisense 12
  
  Pages: 37-47
- Data Source
  KAKENHI-PROJECT-20790610
[Journal Article] ALSの遺伝子治療2008
- Author(s)
  久保寺隆行, 横田隆徳
- Journal Title
  
  Clinical Neuroscience
  
  Pages: 337-339
- Data Source
  KAKENHI-PROJECT-20790610
[Journal Article] ALSの遺伝子治療2008
- Author(s)
  久保寺隆行, 横田隆徳
- Journal Title
  
  Clinical Neuroscience 26
  
  Pages: 337-339
- Data Source
  KAKENHI-PROJECT-20790610
[Journal Article] siRNAの生体内における問題点2007
- Author(s)
  久保寺隆行、横田隆徳
- Journal Title
  
  BIO INDUSTRY 24(6)
  
  Pages: 22-28
- Data Source
  KAKENHI-PROJECT-19659222
[Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA.2007
- Author(s)
  Yokota T, Sasaguri H, Yamada H, Unno T, Yamamoto T, Kubodera T, Anzai M, Mitani T, Mizusawa H
- Journal Title
  
  Arch Neurol 64
  
  Pages: 145-146
- Data Source
  KAKENHI-PROJECT-18659256
[Journal Article] New RNAi strategy for selective suppression of mutant allele in polyglutamine disease.2005
- Author(s)
  Kubodera T, Yokota T, Ishikawa K, Mizusawa H
- Journal Title
  
  Oligonucleotides 15
  
  Pages: 298-302
- Data Source
  KAKENHI-PROJECT-17659260
[Presentation] shRNA-Mediated Gene Silencing in Non-Human Primates with AAV82009
- Author(s)
  Takayuki Kubodera, Shinga Ohira, Yuko Katakai, Hirofumi Akari, Yukihiko Hirai, Takashi Shimada, Hiroaki Mizukami, Keiya Ozawa, Hidehiro Mizusawa, Takanori Yokota
- Organizer
  第15回日本遺伝子治療学会学術集会
- Place of Presentation
  大阪大学コンベンションセンター
- Data Source
  KAKENHI-PROJECT-20790610
[Presentation] siRNA発現アデノ随伴ウイルスベクターを用いた家族性アミロイドポリニューロパチー(FAP)の遺伝子治療2009
- Author(s)
  久保寺隆行, 大平進嘉, 横田隆徳, 水澤英洋
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際センター
- Data Source
  KAKENHI-PROJECT-20790610
[Presentation] 変異遺伝子特異的なRNA干渉法のin vivoへの応用2008
- Author(s)
  久保寺隆行, 山田宏美, 横田隆徳, 水澤英洋
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-20790610
[Presentation] In vivo Application of a New RNAi Strategy for selective Suppression of a Mutant Allele to Any Mutation.2008
- Author(s)
  Kubodera T, Yamada H, Ito K, Anzai M, Mitani T, Miiusawa H, Yokota T
- Organizer
  ASGT 11^<th> Annual Meeting
- Place of Presentation
  Boston, Massachusettes
- Data Source
  KAKENHI-PROJECT-20790610
[Presentation] In vivo Application of a New RNAi Strategy for selective Suppression of a Mutant Allele to Any Mutation.2008
- Author(s)
  Kubodera T, Yamada H, Ito K, Anzai M, Mitani T, Mizusawa H, Yokota T
- Organizer
  ASGT 11th Annual Meeting
- Place of Presentation
  Boston, Massachusettes
- Data Source
  KAKENHI-PROJECT-20790610
[Presentation] LIVER TOXICITY INDUCED BY AAV-DELIVERED SHORT HAIEPINRNA(shRNA).2007
- Author(s)
  海野俊紀、久保寺隆行、村山祥子、大平進嘉、李一、仁科一隆、猪狩亨、江石義信、平井幸彦、島田隆、横田隆徳、水澤英洋
- Organizer
  日本遺伝子治療学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19659222
[Presentation] shRNA発現アデノ随伴ウイルスベクターを用いた遺伝子治療の可能性2007
- Author(s)
  久保寺隆行、横田隆徳、水澤英洋
- Organizer
  日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19659222

1. 横田隆徳 (90231688)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results

KUBODERA Takayuki 久保寺 隆行

Research Projects

Research Products

Co-Researchers

In Vivo Application of an RNAi Strategy for the Selective Suppression of a Mutant AllelePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規siRNAデザインによるサルを用いた家族性アミロイドポリニューロパチーの治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

いかなる変異に対しても特異的な新規RNA干渉法のin vivoでの有効性の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ポリグルタミン病のCAGリピートは2本鎖様なって毒性をもつPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Silencing efficiency differs among tissues and endogeneous microRNA pathway is preserved in short hairpin RNA transgenic mice2009

Author(s)

Journal Title

Data Source

[Journal Article] Silencing efficiency differs among tissues and endogeneous microRNA pathway is preserved in short hairpin RNA transgenic mice2009

Author(s)

Journal Title

Data Source

[Journal Article] Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol2008

Author(s)

Journal Title

Data Source

[Journal Article] ALSの遺伝子治療2008

Author(s)

Journal Title

Data Source

[Journal Article] ウイルスベクターを用いたshRNAによる遺伝子治療の現状と問題点2008

Author(s)

Journal Title

Data Source

[Journal Article] ALSの遺伝子治療2008

Author(s)

Journal Title

Data Source

[Journal Article] ALSの遺伝子治療2008

Author(s)

Journal Title

Data Source

[Journal Article] siRNAの生体内における問題点2007

Author(s)

Journal Title

Data Source

[Journal Article] Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA.2007

Author(s)

Journal Title

Data Source

[Journal Article] New RNAi strategy for selective suppression of mutant allele in polyglutamine disease.2005

Author(s)

Journal Title

Data Source

[Presentation] shRNA-Mediated Gene Silencing in Non-Human Primates with AAV82009

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] siRNA発現アデノ随伴ウイルスベクターを用いた家族性アミロイドポリニューロパチー(FAP)の遺伝子治療2009

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 変異遺伝子特異的なRNA干渉法のin vivoへの応用2008

Author(s)

KUBODERA Takayuki 久保寺隆行