Hosoi Toru 細井徹

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HOSOI Toru 細井徹

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Researcher Number	40379889
Other IDs
Affiliation (Current)	2025: 山陽小野田市立山口東京理科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2025: 山陽小野田市立山口東京理科大学, 薬学部, 教授 2020 – 2023: 山陽小野田市立山口東京理科大学, 薬学部, 教授 2019: 広島大学, 医系科学研究科(薬), 准教授 2018: 広島大学, その他の研究科, 准教授 2017 – 2018: 広島大学, 医歯薬保健学研究科(薬), 准教授 … More 2015 – 2016: 広島大学, 医歯薬保健学研究院(薬), 准教授 2015: 広島大学, 医歯薬保健学研究院, 准教授 2014: 広島大学, 医歯薬保健学研究院, 講師 2013: 広島大学, 大学院医歯薬保健学研究院, 講師 2012: 広島大学, 医歯薬保健学研究院, 講師 2012: 広島大学, 大学院・医歯薬保健学研究院, 講師 2012: 広島大学, 大学院・医歯薬保健学総合研究院, 講師 2011: 広島大学, 医歯(薬)学総合研究科, 講師 2007 – 2011: Hiroshima University, 大学院・医歯薬学総合研究科, 講師 2005 – 2006: 広島大学, 大学院医歯薬学総合研究科, 助手 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Pharmacology in pharmacy / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Complex Systems Disease Theory Except Principal Investigator Drug development chemistry / Basic Section 47040:Pharmacology-related / Basic Section 58010:Medical management and medical sociology-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator レプチン / 小胞体ストレス / 肥満 / レプチン抵抗性 / 神経細胞 / グリア細胞 / アデノシ / ホモシステイン / 糖尿病 / SOCS 3 … More / STAT 3 / 生活習慣病 / PTP1B / STAT3 / II型糖尿病 / 神経変性疾患 / CHOP / Akt / アポトーシス / グリア / PI3K / AKT / ゲルダナマイシン … More Except Principal Investigator 小胞体ストレス / 肥満 / レプチン / 好塩基球 / マスト細胞 / アレルギー / 健康サポート薬局 / 生活習慣病 / 平均寿命 / 健康寿命 / アンケート / こころの健康サポート / 健康サポート / ビッグデータ / エピジェネティック / エピジェネティクス / ホモシステイン / フルルビプロフェン / アルデヒドデヒドロゲナーゼ / ALDH / 抗肥満薬 / レプチン抵抗性 Less

肥満制御の新機構解明―細胞膜と小胞体のクロストークによる制御―Principal Investigator
- Principal Investigator
  
  細井徹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Do Food Additives Cause Obesity?-Elucidation of the mechanism of action on leptin receptor signaling-Principal Investigator
- Principal Investigator
  
  細井徹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tokyo University of Science, Yamaguchi
The role of ER stress proteins for mast cell functions
- Principal Investigator
  
  Koichiro Ozawa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Hiroshima University
Elucidation of the molecular mechanisms and treatment against physiological factor/ER stress-induced obesity/metabolic syndromePrincipal Investigator
- Principal Investigator
  
  Hosoi Toru
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Tokyo University of Science, Yamaguchi
  Hiroshima University
Elucidation of the strategy towards the healthy life expectancy stretching by the use of big data
- Principal Investigator
  
  池田佳代
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58010:Medical management and medical sociology-related
- Research Institution
  Hiroshima University
Prediction of disease progression by analyzing endoplasmic reticulum stress sensor systemPrincipal Investigator
- Principal Investigator
  
  Hosoi Toru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Complex Systems Disease Theory
- Research Institution
  Tokyo University of Science, Yamaguchi
  Hiroshima University
ER stress-induced leptin resistance and epigenetic mechanisms in regulating obesity
- Principal Investigator
  
  Ozawa Koichiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Hiroshima University
Elucidation of the mechanisms and pharmacological target for metabolic syndrome by analyzing endoplasmic reticulum stress, which is mediated through physiological factor and cell-to-cell communicationPrincipal Investigator
- Principal Investigator
  
  Hosoi Toru
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Hiroshima University
Elucidation of novel therapeutics of endoplasmic reticulum stress-related disease targeting aldehyde dehydrogenase
- Principal Investigator
  
  Ozawa Koichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hiroshima University
Elucidation of the treatment against metabolic syndrome by regulating endoplasmic reticulum functionPrincipal Investigator
- Principal Investigator
  
  Hosoi Toru
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Hiroshima University
Novel therapy for metabolic syndrome targeting ER stressPrincipal Investigator
- Principal Investigator
  
  HOSOI Toru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
Development of novel drug for obesity targeting endoplasmic reticulum stress
- Principal Investigator
  
  OZAWA Koichiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Hiroshima University
Elucidation of novel mechanisms of obesity and the therapeutic drug -elucidation of leptin resistance-Principal Investigator
- Principal Investigator
  
  HOSOI Toru
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
Elucidation of the mechanisms of metabolic syndrome caused by leptin resistance~the role of endoplasmic reticulum stress~Principal Investigator
- Principal Investigator
  
  HOSOI Toru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University
神経変性疾患による小胞体ストレスに関与する新規因子の同定と創薬への試みPrincipal Investigator
- Principal Investigator
  
  細井徹
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hiroshima University

[Journal Article] 肥満病態におけるレプチン抵抗性成立に対するアルデヒド類の影響2022
- Author(s)
  野田康裕，渋谷優稀，中川直，細井　徹
- Journal Title
  
  アグリバイオ
  
  Volume: 6 Pages: 53-56
- Data Source
  KAKENHI-PROJECT-22KK0109
[Journal Article] SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones2022
- Author(s)
  Nakagawa T, Morohoshi A, Nagasawa Y, Nakagawa M, Hosogane M, Noda Y, Hosoi T, Nakayama K.
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 12 Pages: 110541-110541
- DOI
  10.1016/j.celrep.2022.110541
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07837, KAKENHI-PROJECT-20K12157, KAKENHI-PROJECT-18KK0463, KAKENHI-PROJECT-21H02458
[Journal Article] 広島市内薬局薬剤師を対象とした遺伝子検査に関する意識調査2022
- Author(s)
  池田佳代，細井徹，吉井美智子，杉山政則，小澤光一郎
- Journal Title
  
  社会薬学
  
  Volume: 41(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K10559
[Journal Article] Central Acting Hsp10 Regulates Mitochondrial Function, Fatty Acid Metabolism, and Insulin Sensitivity in the Hypothalamus2021
- Author(s)
  Wardelmann Kristina、Rath Michaela、Castro Jos? Pedro、Bl?mel Sabine、Schell Mareike、Hauffe Robert、Schumacher Fabian、Flore Tanina、Ritter Katrin、Wernitz Andreas、Hosoi Toru、Ozawa Koichiro、Kleuser Burkhard、Wei? J?rgen、Sch?rmann Annette、Kleinridders Andr?
- Journal Title
  
  Antioxidants
  
  Volume: 10 Issue: 5 Pages: 711-711
- DOI
  10.3390/antiox10050711
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0463
[Journal Article] Thermal Proteome Profiling Reveals Glutathione Peroxidase 4 as the Target of the Autophagy Inducer Conophylline2021
- Author(s)
  Kakegawa Junya、Ohtsuka Satoshi、Yokoyama Masahiro、Hosoi Toru、Ozawa Koichiro、Hatanaka Takashi
- Journal Title
  
  Molecular Pharmacology
  
  Volume: 100 Issue: 3 Pages: 181-192
- DOI
  10.1124/molpharm.121.000243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0463
[Journal Article] Possible Involvement of MyD88 in Regulating Stress Response in Mice2021
- Author(s)
  Hosoi Toru、Yamawaki Yosuke、Kimura Hitomi、Honda Shoko、Ozawa Koichiro
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 15 Pages: 621446-621446
- DOI
  10.3389/fnins.2021.621446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KK0463, KAKENHI-PROJECT-18K06549, KAKENHI-PROJECT-18KT0072
[Journal Article] The possible role of biochanin A in ameliorating endoplasmic reticulum stress-induced leptin resistance2021
- Author(s)
  Horiuchi Keigo、Tsuchio Kyoji、Matsushima Goshi、Thon Mina、Hosoi Toru、Ozawa Koichiro
- Journal Title
  
  NeuroReport
  
  Volume: 32 Issue: 12 Pages: 983-987
- DOI
  10.1097/wnr.0000000000001674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18KK0463
[Journal Article] Anticancer effect of nor-wogonin (5, 7, 8-trihydroxyflavone) on human triple-negative breast cancer cells via downregulation of TAK1, NF-κB, and STAT3.2019
- Author(s)
  Abd El-Hafeez A.A., Khalifa H.O., Mahdy E.A.M., Sharma V., Hosoi T., Ghosh P., Ozawa K., Montano M.M., Fujimura T., Ibrahim A.R.N., Abdelhamid M.A.A., Pack S.P., Shouman S.A., and Kawamoto S.
- Journal Title
  
  Pharmacological Reports
  
  Volume: 71 Issue: 2 Pages: 289-298
- DOI
  10.1016/j.pharep.2019.01.001
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06549
[Journal Article] Immobilization stress induces XBP1 splicing in the mouse brain.2019
- Author(s)
  Hosoi T, Kimura H, Yamawaki Y, Mori K, Ozawa K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 508 Issue: 2 Pages: 516-520
- DOI
  10.1016/j.bbrc.2018.11.167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11670, KAKENHI-PROJECT-18KT0072, KAKENHI-PROJECT-16K08271, KAKENHI-PROJECT-18K06549
[Journal Article] Grapefruit juice exerts anti-osteoporotic activities in a prednisolone-induced osteoporosis rat femoral fracture model, possibly via the RANKL/OPG axis.2019
- Author(s)
  Bastawy EM, Ahmed RR, Abd El-Hafeez AA, Abd El-Hady FK, Hosoi T, Ozawa K, El-Ganzuri MA.
- Journal Title
  
  Cytotechnology
  
  Volume: 71 Issue: 4 Pages: 769-783
- DOI
  10.1007/s10616-019-00321-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06549, KAKENHI-PROJECT-18KT0072, KAKENHI-PROJECT-18KK0463
[Journal Article] Possible involvement of 4-hydroxy-2-nonenal in the pathogenesis of leptin resistance in obesity.2019
- Author(s)
  Hosoi T., Kuwamura A., Thon M., Tsuchio K., Abd El-Hafeez A.A., & Ozawa K.
- Journal Title
  
  American Journal of Physiology- Cell Physiology
  
  Volume: 316 Issue: 5 Pages: C641-C648
- DOI
  10.1152/ajpcell.00080.2018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06549
[Journal Article] Incorporation of the Endoplasmic Reticulum Stress-Induced Spliced Form of XBP1 mRNA in the Exosomes2018
- Author(s)
  Hosoi T., Nakashima M., and Ozawa K.
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 9 Pages: 1357-1357
- DOI
  10.3389/fphys.2018.01357
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18KT0072, KAKENHI-PROJECT-18K06549
[Journal Article] Endospanin 1 affects oppositely body weight regulation and glucose homeostasis by differentially regulating central leptin signaling.2017
- Author(s)
  Vauthier V., Roujeau C., Chen P., Sarkis C., Migrenne S., Hosoi T., Ozawa K., Rouille Y., Foretz M., Mallet J., Launay J., Magnan C., Jockers R. and Dam J.
- Journal Title
  
  Molecular Metabolism
  
  Volume: 6 Issue: 1 Pages: 159-172
- DOI
  10.1016/j.molmet.2016.10.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08271
[Journal Article] Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in Neuronal Cells2017
- Author(s)
  Thon M., Hosoi T., Chanbora C., and Ozawa K.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 8 Pages: 1161-1164
- DOI
  10.1248/bpb.b17-00311
- NAID
  130005876267
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08271, KAKENHI-PROJECT-15K08025
[Journal Article] The Mechanisms and Pharmacological Strategy for Treatment of ER Stress-induced Metabolic Syndrome2016
- Author(s)
  Hosoi T, Ozawa K.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 136 Issue: 6 Pages: 827-830
- DOI
  10.1248/yakushi.15-00292-5
- NAID
  130005154182
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2016-06-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08271
[Journal Article] Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress to Ameliorate Leptin Resistance in Obesity.2016
- Author(s)
  Hosoi T, Ozawa K.
- Journal Title
  
  Front Endocrinol
  
  Volume: 7 Pages: 59-59
- DOI
  10.3389/fendo.2016.00059
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08025, KAKENHI-PROJECT-16K08271
[Journal Article] Dehydroascorbic acid-induced endoplasmic reticulum stress and leptin resistance in neuronal cells.2016
- Author(s)
  Thon M, Hosoi T, Ozawa K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 478 Issue: 2 Pages: 716-720
- DOI
  10.1016/j.bbrc.2016.08.013
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08271
[Journal Article] Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78.2016
- Author(s)
  Thon M, Hosoi T, Ozawa K.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 34312-34312
- DOI
  10.1038/srep34312
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08271
[Journal Article] Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis.2016
- Author(s)
  Thon M, Hosoi T, Ozawa K.
- Journal Title
  
  Front Endocrinol
  
  Volume: 7 Pages: 138-138
- DOI
  10.3389/fendo.2016.00138
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08271
[Journal Article] Flurbiprofen Ameliorates Glucose Deprivation-Induced Leptin Resistance.2016
- Author(s)
  Hosoi T, Suyama Y, Kayano T, Ozawa K.
- Journal Title
  
  Front Pharmacol.
  
  Volume: 7 Pages: 354-354
- DOI
  10.3389/fphar.2016.00354
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08271
[Journal Article] Key role of heat shock protein 90 in leptin-induced STAT3 activation and feeding regulation.2016
- Author(s)
  Hosoi T, Kohda T, Matsuzaki S, Ishiguchi M, Kuwamura A, Akita T, Tanaka J, Ozawa K.
- Journal Title
  
  Br J Pharmacol.
  
  Volume: 173 Issue: 15 Pages: 2434-2445
- DOI
  10.1111/bph.13520
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08271
[Journal Article] Synthesis of a peptide that can translocate to the endoplasmic reticulum.2015
- Author(s)
  Kanako Nakatsu, Toru Hosoi, Keisuke Toyoda, and Koichiro Ozawa.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 460 Issue: 3 Pages: 628-632
- DOI
  10.1016/j.bbrc.2015.03.080
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08025, KAKENHI-PROJECT-25460101
[Journal Article] Possible involvement of 15-deoxy-Δ(12,14) -prostaglandin J2 in the development of leptin resistance.2015
- Author(s)
  Hosoi T, Matsuzaki S, Miyahara T, Shimizu K, Hasegawa Y, Ozawa K.
- Journal Title
  
  J Neurochem.
  
  Volume: 133 Issue: 3 Pages: 343-51
- DOI
  10.1111/jnc.13057
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460101, KAKENHI-PROJECT-15K08025
[Journal Article] Caffeine attenuated ER stress-induced leptin resistance in neurons.2014
- Author(s)
  47. Hosoi T, Toyoda K, Nakatsu K, Ozawa K.
- Journal Title
  
  Neuroscience Letters
  
  Volume: 未確定 Pages: 23-26
- DOI
  10.1016/j.neulet.2014.03.053
- Data Source
  KAKENHI-PROJECT-25460101
[Journal Article] Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells.2014
- Author(s)
  Thon M, Hosoi T, Yoshii M, Ozawa K.
- Journal Title
  
  Sci Rep.
  
  Volume: 4 Issue: 1 Pages: 7096-7096
- DOI
  10.1038/srep07096
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460101
[Journal Article] Therapeutic potential of flurbiprofen against obesity in mice.2014
- Author(s)
  Hosoi T, Baba S, Ozawa K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 449 Issue: 1 Pages: 132-134
- DOI
  10.1016/j.bbrc.2014.04.159
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460101
[Journal Article] TERT attenuated ER stress-induced cell death.2014
- Author(s)
  Hosoi, T., Inoue, Y., Nakatsu, K., Matsushima, N., Kiyose, N., Shimamoto, A., Tahara, H. & Ozawa, K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 447 Issue: 2 Pages: 378-382
- DOI
  10.1016/j.bbrc.2014.04.034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112711, KAKENHI-PROJECT-25460101, KAKENHI-PROJECT-25670030, KAKENHI-PROJECT-26290047, KAKENHI-PROJECT-26310106, KAKENHI-PROJECT-26640091, KAKENHI-PROJECT-221S0001
[Journal Article] Inhibition of inducible nitric oxide synthase and interleukin-1β expression by tunicamycin in cultured glial cells exposed to lipopolysaccharide2014
- Author(s)
  Noguchi J., Takakuwa M., Honda M., Okuma Y., Nomura Y. and Ozawa K.
- Journal Title
  
  Brain Research
  
  Volume: 1558 Pages: 11-17
- DOI
  10.1016/j.brainres.2014.02.035
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24300135, KAKENHI-PROJECT-24590119, KAKENHI-PROJECT-25460101
[Journal Article] Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress.2014
- Author(s)
  45. Hosoi T., Yamaguchi R., Noji K., Matsuo S., Baba S., Toyoda K., Suezawa T., Kayano T., Tanaka S., Ozawa K.
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 441 Issue: 3 Pages: 335-346
- DOI
  10.1002/emmm.201303227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460101
[Journal Article] ER stress-mediated regulation of immune function under glucose-deprived condition in glial cells: up- and down-regulation of PGE2 + IFNγ-induced IL-6 and iNOS expressions.2013
- Author(s)
  44. Hosoi T., Honda M., Oba T., Ozawa K.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 441 Issue: 2 Pages: 525-528
- DOI
  10.1016/j.bbrc.2013.10.109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460101
[Journal Article] Tributyltin-induced endoplasmic reticulum stress and its Ca^<2+>-mediated mechanism2013
- Author(s)
  Isomura M, Kotake Y, Masuda K, Miyara M, Okuda K, Samizo S, Sanoh S, Hosoi T, Ozawa K, Ohta S
- Journal Title
  
  Toxicol Appl Pharmacol
  
  Volume: 272(1) Issue: 1 Pages: 137-46
- DOI
  10.1016/j.taap.2013.05.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310047, KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-24651061, KAKENHI-PROJECT-25460101
[Journal Article] ER stress upregulated PGE2/IFNγ-induced IL-6 expression and down-regulated iNOS expression in glial cells.2013
- Author(s)
  43. Hosoi T., Honda M., Oba T., Ozawa K.
- Journal Title
  
  Scientific Reports
  
  Volume: 3 Issue: 1 Pages: 3388-3388
- DOI
  10.1038/srep03388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460101
[Journal Article] Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance2012
- Author(s)
  Hosoi T, Miyahara T, Kayano T, Yokoyama S, Ozawa K
- Journal Title
  
  Front Endocrinol (Lausanne)
  
  Volume: 3(12) Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells.2012
- Author(s)
  Hosoi T
- Journal Title
  
  Plos One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790088
[Journal Article] Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice2012
- Author(s)
  Yokoyama S, Hosoi T, Ozawa K
- Journal Title
  
  Gene
  
  Volume: 497(2) Pages: 340-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance2012
- Author(s)
  Hosoi T, Miyahara T, Kayano T, Yokoyama S, Ozawa K
- Journal Title
  
  Front Endocrinol (Lausanne)
  
  Volume: 3:12 Pages: 1-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790088
[Journal Article] Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease: endoplasmic reticulum stress and immunological stress in pathogenesis of Alzheimer's disease2012
- Author(s)
  Hosoi T, Ozawa K
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118(3) Pages: 319-24
- NAID
  10030455370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress2012
- Author(s)
  Mimori S, Okuma Y, Kaneko M, Kawada K, Hosoi T, Ozawa K, Nomura Y, Hamana H.
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35(1) Pages: 84-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790088
[Journal Article] Molecular approaches to the treatment, prophylaxis, and diagnosis of Alzheimer's disease: endoplasmic reticulum stress and immunological stress in pathogenesis of Alzheimer's disease2012
- Author(s)
  Hosoi T, Ozawa K
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118(3) Pages: 319-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790088
[Journal Article] Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress2012
- Author(s)
  Mimori S, Okuma Y, Kaneko M, Kawada K, Hosoi T, Ozawa K, Nomura Y, Hamana H
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35(1) Pages: 84-90
- NAID
  130001872347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice2012
- Author(s)
  Yokoyama S, Hosoi T, Ozawa K
- Journal Title
  
  Gene
  
  Volume: 497(2) Pages: 340-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790088
[Journal Article] Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells.2012
- Author(s)
  Toru Hosoi
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance2012
- Author(s)
  Hosoi T
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 3 Pages: 1-5
- DOI
  10.3389/fendo.2012.00012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100, KAKENHI-PROJECT-23790088
[Journal Article] Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease:<BR>Endoplasmic Reticulum Stress and Immunological Stress in Pathogenesis of Alzheimer’s Disease2012
- Author(s)
  Hosoi T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 118 Issue: 3 Pages: 319-324
- DOI
  10.1254/jphs.11R09FM
- NAID
  10030455370
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100, KAKENHI-PROJECT-23790088
[Journal Article] Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells2012
- Author(s)
  Hosoi T, Korematsu K, Horie N, Suezawa T, Okuma Y, Nomura Y, Ozawa K
- Journal Title
  
  PLoS One
  
  Volume: 7(6)
- NAID
  120005300501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Inhibition of casein kinase 2 modulates XBP1-GRP78 arm of unfolded protein responses in cultured glial cells2012
- Author(s)
  Hosoi T, Korematsu K, Horie N, Suezawa T, Okuma Y, Nomura Y, Ozawa K
- Journal Title
  
  PLoS One
  
  Volume: 7(6)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790088
[Journal Article] A unique modulator of endoplasmic reticulum stress-signalling pathways : the novel pharmacological properties of amiloride in glial cells.2010
- Author(s)
  Hosoi T
- Journal Title
  
  Br J Pharmacol. 159
  
  Pages: 428-437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice.2010
- Author(s)
  Hosoi T, Yokoyama S, Matsuo S, Akira S, Ozawa K
- Journal Title
  
  PLoS ONE 5(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] MyD88 plays a key role in LPS-induced Stat3 activation in the hypothalamus.2010
- Author(s)
  Yamawaki Y., Kimura H., Hosoi T., Ozawa K.
- Journal Title
  
  American Journal of Physiology Regulatory Integrative and Comparative Physiology 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress.2010
- Author(s)
  Hosoi T., Tamubo T., Horie N., Okuma Y., Nomura Y., Ozawa K.
- Journal Title
  
  Journal of Pharmacological Science 114
  
  Pages: 230-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress.2010
- Author(s)
  Hosoi T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114 Pages: 230-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Endoplasmic reticulum stress in disease : mechanisms and therapeutic opportunities.2010
- Author(s)
  Hosoi T
- Journal Title
  
  Clin Sci (Loud). 118
  
  Pages: 19-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress.2010
- Author(s)
  Hosoi T
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114 Pages: 230-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice.2010
- Author(s)
  Hosoi T
- Journal Title
  
  PLoS One
  
  Volume: 5 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] Endoplasmic reticulum stress in disease : mechanisms and therapeutic opportunities.2010
- Author(s)
  Hosoi T., Ozawa K.
- Journal Title
  
  (2010)Clinical Science (Lond). 118
  
  Pages: 19-29
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] TEK/Tie2 is a novel gene involved in endoplasmic reticulum stress2010
- Author(s)
  Hosoi T, Tamubo T, Horie N, Okuma Y, Nomura Y, Ozawa K
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 114(2) Pages: 230-3
- NAID
  10027746811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Myeloid differentiation factor 88 (MyD88)-deficiencyincreases risk of diabetes in mice.2010
- Author(s)
  Hosoi T
- Journal Title
  
  PLoS One
  
  Volume: 5 Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Homocysteine induces X-box binding protein 1 splicing in the mice brain.2010
- Author(s)
  Hosoi T., Ogawa K., Ozawa K.
- Journal Title
  
  Neurochemistry International 56
  
  Pages: 216-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice2010
- Author(s)
  Hosoi T, Yokoyama S, Matsuo S, Akira S, Ozawa K
- Journal Title
  
  PLoS One
  
  Volume: 5(9)
- NAID
  120002737828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590100
[Journal Article] Homocysteine induces X-box-binding protein 1 splicing in the mice brain.2010
- Author(s)
  Hosoi T
- Journal Title
  
  Neurochem Int. 56
  
  Pages: 216-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] A unique modulator of endoplasmic reticulum stress-signalling pathways : the novel pharmacological properties of amiloride in glial cells.2010
- Author(s)
  Hosoi T., Kume A., Otani K., Oba T., Ozawa K.
- Journal Title
  
  British Journal of Pharmacology 159
  
  Pages: 428-437
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells2009
- Author(s)
  Hosoi T
- Journal Title
  
  Neurochemistry International 54
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance.2009
- Author(s)
  Hosoi T, Ozawa K.
- Journal Title
  
  Journal of Medical Investigation 56
  
  Pages: 296-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790079
[Journal Article] Effect of pranoprofen on endoplasmic reticulum stress in the primary cultured glial cells2009
- Author(s)
  Hosoi T., Sasaki M. Baba S. & Ozawa K.
- Journal Title
  
  Neurochemistry International 54(1)
  
  Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Vanadate inhibits endoplasmic reticulum stress responses2008
- Author(s)
  Hosoi T., Saito A., Kume A., Okuma Y., Nomura Y. & Ozawa K.
- Journal Title
  
  European Journal of Pharmacology 594 (1-3)
  
  Pages: 44-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Endoplasmic reticulum stress induces leptin resistance2008
- Author(s)
  Hosoi T
- Journal Title
  
  Molecular Pharmacology 74
  
  Pages: 1610-1619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Endoplasmic reticulum stress induces leptin resistance2008
- Author(s)
  Hosoi T., Sasaki M., Miyahara T., Hashimoto C., Matsuo S., Yoshii M. & Ozawa K.
- Journal Title
  
  Molecular Pharmacology 74 (6)
  
  Pages: 1610-1619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Vanadate inhibits endoplasmic reticulum stress responses2008
- Author(s)
  Hosoi T
- Journal Title
  
  European Journal of Pharmacology 594
  
  Pages: 44-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Akt up- and down-regulation in response to endoplasmic reticulum stress.2007
- Author(s)
  Hosoi T., Hyoda K., Okuma Y., Nomura Y. & Ozawa K
- Journal Title
  
  Brain Research 1152
  
  Pages: 27-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease.2007
- Author(s)
  Hosoi T
- Journal Title
  
  Cell Res. 17巻 2号
  
  Pages: 184-186
- Data Source
  KAKENHI-PROJECT-17790064
[Journal Article] Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression.2007
- Author(s)
  Hosoi T
- Journal Title
  
  Eur J Pharmacol. 554巻 1号
  
  Pages: 8-11
- Data Source
  KAKENHI-PROJECT-17790064
[Journal Article] Akt up-and down-regulation in response to endoplasmic reticulum stress.2007
- Author(s)
  Hosoi T
- Journal Title
  
  Brain Research 1152
  
  Pages: 27-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease2007
- Author(s)
  Hosoi T., Hyoda K., Okuma Y., Nomura Y. & Ozawa K.
- Journal Title
  
  Cell Research 17 (2)
  
  Pages: 184-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression2007
- Author(s)
  Hosoi T., Hyoda K., Okuma Y., Nomura Y. & Ozawa K.
- Journal Title
  
  European Journal of Pharmacology 554 (1)
  
  Pages: 8-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Inhibitory effect of 4-(2-aminoethy1)-benzenesulfony1 fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression.2007
- Author(s)
  Hosoi T
- Journal Title
  
  European Journal of Pharmacology 554
  
  Pages: 8-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] Geldanamycin induces CHOP expression through a 4-(2-aminoethy1)-benzenesulfony1 fluoride-responsive serine protease.2007
- Author(s)
  Hosoi T
- Journal Title
  
  Cell Research 17
  
  Pages: 184-186
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790059
[Journal Article] 2-Aminopurine inhibits leptin receptor signal transduction.2006
- Author(s)
  Hosoi T
- Journal Title
  
  Eur J Pharmacol. 553巻 1-3号
  
  Pages: 61-66
- Data Source
  KAKENHI-PROJECT-17790064
[Journal Article] PI3K-Akt inactivation induced CHOP expression in endoplasmic reticulum-stressed cells.2006
- Author(s)
  Hyoda K, Hosoi T, Horie N, Okuma Y, Ozawa K, Nomura Y.
- Journal Title
  
  Biochem Biophys Res Commun. 340(1)
  
  Pages: 286-290
- Data Source
  KAKENHI-PROJECT-17790064
[Journal Article] STAT3 activation and c-FOS expression in the brain following peripheral administration of bacterial DNA.2005
- Author(s)
  Sako K, Okuma Y, Hosoi T, Nomura Y.
- Journal Title
  
  J Neuroimmunol. 158(1-2)
  
  Pages: 49-49
- Data Source
  KAKENHI-PROJECT-17790064
[Journal Article] LPS induces stefin A3 expression in mouse primary cultured glial cells.2005
- Author(s)
  Hosoi T, Suzuki S, Okuma Y, Kawakami A, Ogawa N, Ozawa K, Nomura Y.
- Journal Title
  
  Brain Res Mol Brain Res. 140(1-2)
  
  Pages: 138-141
- Data Source
  KAKENHI-PROJECT-17790064
[Journal Article] Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8.2005
- Author(s)
  Hosoi T, Okuma Y, Ono A, Nomura Y.
- Journal Title
  
  Biol Pharm Bull. 20(8)
  
  Pages: 1514-1516
- Data Source
  KAKENHI-PROJECT-17790064
[Journal Article] Novel pathway for LPS-induced afferent vagus nerve activation : possible role of nodose ganglion.2005
- Author(s)
  Hosoi T, Okuma Y, Matsuda T, Nomura Y.
- Journal Title
  
  Auton Neurosci. 120(1-2)
  
  Pages: 104-107
- Data Source
  KAKENHI-PROJECT-17790064
[Journal Article] Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.
- Author(s)
  Kubota K, Niinuma Y, Kaneko M, Okuma Y, Sugai M, Omura T, Uesugi M, Uehara T, Hosoi T, Nomura Y.
- Journal Title
  
  J Neurochem. [Epub ahead of print]
- Data Source
  KAKENHI-PROJECT-17790064
[Patent] レプチン抵抗性を改善および/または予防するための薬学的組成物、並びにその使用2010
- Inventor(s)
  細井徹, 小澤孝一郎
- Industrial Property Rights Holder
  国立大学法人広島大学
- Filing Date
  2010-04-14
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] マスト細胞の活性化におけるIRE1αの役割解明2024
- Author(s)
  松嶋剛志、岡本花乃、松井優里、梅田渚、中川直、柳瀬雄輝、細井徹、吉井美智子、小澤孝一郎
- Organizer
  日本薬学会144年会
- Data Source
  KAKENHI-PROJECT-21K06577
[Presentation] 全国における地域住民の薬局での健康サポートに関する意識調査解析2024
- Author(s)
  池田佳代、三浦常代、細井徹、野村祐仁、豊見雅文、小澤光一郎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] 喫煙と飲酒の健康への影響　～NDBオープンデータを用いた解析～2023
- Author(s)
  池田佳代，細井徹，小澤光一郎
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] IgE受容体を介したマスト細胞活性化におけるIRE1αの役割解明2023
- Author(s)
  岡本花乃、松嶋剛志、中川直、細井徹、柳瀬雄輝、吉井美智子、小澤孝一郎
- Organizer
  第62回　日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-21K06577
[Presentation] 肥満・アルコール代謝関連遺伝体質及び漢方的肥満体質を活用した「健康フェア」データ（全165名）の解析2023
- Author(s)
  島崎一郎、池田佳代、細井徹、三浦常代、春日真由、重留佳代子、若生あき、大谷純一、中野真豪、豊見雅文、小澤光一郎
- Organizer
  第42回広島県薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] 薬局薬剤師の地域住民を対象とした健康サポートへのさらなる貢献をめざした検討2022
- Author(s)
  三浦常代，池田佳代，細井徹，吉井美智子，杉山政則，中野真豪，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  第55回日本薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] オランザピン誘発性肥満病態発現メカニズムの解明―レプチン抵抗性の関与2022
- Author(s)
  森本理子，栗屋花蓮，指山祥子，井上夏奈，中川直，野田泰裕，細井徹
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] 「健康フェア」データによる「肥満関連遺伝体質」及び「漢方的肥満体質」の解析2022
- Author(s)
  島崎一郎，池田佳代，細井徹，三浦常代，春日真由，重留佳代子，若生あき，大谷純一，中野真豪，豊見雅文，小澤光一郎
- Organizer
  第55回日本薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] NDBオープンデータを活用した地域住民の糖尿病関連因子の健康寿命への影響評価2022
- Author(s)
  池田佳代，細井徹，吉井美智子，杉山政則，小澤光一郎
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] マスト細胞の脱顆粒に対するAPY29の効果2022
- Author(s)
  松嶋剛志、梅田渚、垣本真衣、柳瀬雄輝、細井徹、小澤光一郎
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K06577
[Presentation] 薬局での地域住民の「こころの健康サポート」をめざしたNDBオープンデータを活用した検討2022
- Author(s)
  池田佳代，細井徹，小澤光一郎
- Organizer
  日本社会薬学会第40年会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] 小胞体ストレスセンサタンパク阻害薬によるマスト細胞機能抑制機構の解明2022
- Author(s)
  松嶋剛志，梅田渚，垣本真衣，柳瀬雄輝，細井徹，小澤光一郎
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] PERK阻害剤GSK2606414のパーキンソン病モデル細胞に対する小胞体ストレス非依存的保護作用2022
- Author(s)
  野田泰裕，中川直，細井徹
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] ホモシステインのレプチン抵抗性形成機構―レプチンを介したJAK2-STAT3シグナル抑制機構の解明―2022
- Author(s)
  栗屋花蓮，Arini Isnani Preninka，吉井美智子，柳瀬雄輝，Ralf Jockers，Julie Dam，小澤光一郎，細井徹
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] 「健康フェア（漢方）」における漢方薬局の取り組み及び漢方的肥満体質と肥満関連遺伝子との関連性について2021
- Author(s)
  島崎一郎，池田佳代，三浦常代，細井徹，吉井美智子，杉山政則，大谷純一，中野真豪，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  第41回広島県薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] Biochanin Aは小胞体ストレス誘導性のレプチン抵抗性を減弱する2021
- Author(s)
  堀内契吾, 槌尾恭二, 松嶋剛志, Mina Thon, 細井徹, 小澤孝一郎
- Organizer
  第141回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] Biochanin Aは小胞体ストレス誘導性のレプチン抵抗性を減弱する2021
- Author(s)
  堀内契吾, 槌尾恭二, 松嶋剛志, Mina Thon, 細井徹, 小澤孝一郎
- Organizer
  第141回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 中枢機能におけるAldehyde dehydrogenase 2 の役割解明2021
- Author(s)
  下垣和香, 森光平, 城田真輝, 中川直, 北川恭子, 柳瀬雄輝, 細井徹, 小澤光一郎
- Organizer
  第141回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] BRET 解析によるレプチン受容体シグナル制御へのアデノシンの役割の解明2021
- Author(s)
  細井徹, 松浦武典, シルバアニジア, 和田萌々恵, 松﨑周, 杉山礼隆, 児玉尚士, ジョーカーズラルフ, ダムジュリエ, 小澤光一郎
- Organizer
  第141回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] 中枢機能におけるAldehyde dehydrogenase 2 の役割解明2021
- Author(s)
  下垣和香, 森光平, 城田真輝, 中川直, 北川恭子, 柳瀬雄輝, 細井徹, 小澤孝一郎
- Organizer
  第141回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 薬局薬剤師の職務に関する地域住民の意識調査2021
- Author(s)
  三浦常代，池田佳代，細井徹，吉井美智子，杉山政則，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] アデノシンによるレプチン抵抗性の受容体機能解析―BRET解析による検討2021
- Author(s)
  細井　徹，松浦　武典，Anisia Silva，和田　萌々恵，松﨑　周，杉山　礼隆，児玉　尚士，Julie Dam，Ralf Jockers，小澤　光一郎
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] NDBオープンデータからみた地域住民の健康寿命に関与する生活習慣2021
- Author(s)
  池田佳代，細井徹，吉井美智子，杉山政則，小澤光一郎
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] 広島市域住民の考える薬局薬剤師職務及びその期待に関する意識調査2021
- Author(s)
  池田佳代，三浦常代，細井徹，吉井美智子，杉山政則，中野真豪，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  第41回広島県薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] 漢方薬局としての「健康フェア（漢方）」における取り組み2021
- Author(s)
  島崎一郎，池田佳代，細井徹，三浦常代，吉井美智子，杉山政則，大谷純一，中野真豪，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] ストレス負荷によるグリア細胞からのadenosine遊離と神経細胞におけるレプチン抵抗性形成機構の解析2020
- Author(s)
  和田　萌々恵，松浦　武典，細井　徹，松﨑　周，杉山　礼隆，児玉　尚士，小澤　光一郎
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] 神経細胞のレプチン抵抗性に対するグリア細胞由来adenosineの影響2020
- Author(s)
  和田萌々恵，松浦武典，細井徹，柳瀬雄輝，松﨑周，杉山礼隆，児玉尚士，小澤光一郎
- Organizer
  第137回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] 肥満病態時のレプチン抵抗性形成へのグリア細胞の役割2020
- Author(s)
  佐藤颯斗，細井　徹，柳瀬　雄輝，長谷川由貴，松村奈美，小澤光一郎
- Organizer
  第137回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] ストレス負荷によるグリア細胞からのadenosine遊離と神経細胞におけるレプチン抵抗性形成機構の解析2020
- Author(s)
  和田　萌々恵，松浦　武典，細井　徹，松﨑　周，杉山　礼隆，児玉　尚士，小澤　光一郎
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 薬局における健康サポートのための地域住民の生活習慣及び意識調査2020
- Author(s)
  池田佳代、細井徹、三浦常代、吉井美智子、杉山政則、野村祐仁、豊見雅文、小澤光一郎
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] 肥満病態時のレプチン抵抗性形成へのグリア細胞の役割2020
- Author(s)
  佐藤颯斗，細井　徹，柳瀬　雄輝，長谷川由貴，松村奈美，小澤孝一郎
- Organizer
  第137回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 神経細胞のレプチン抵抗性に対するグリア細胞由来adenosineの影響2020
- Author(s)
  和田萌々恵，松浦武典，細井徹，柳瀬雄輝，松﨑周，杉山礼隆，児玉尚士，小澤孝一郎
- Organizer
  第137回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 「健康フェア」における肥満関連遺伝子検査及び東洋医学的解析の活用2020
- Author(s)
  島崎一郎，池田佳代，細井徹，三浦常代，吉井美智子，杉山政則，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  第40回広島県薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] 病態時におけるグリア-ニューロンインターラクションを介した肥満発症機構の解明―レプチン抵抗性のメカニズムの解明―2020
- Author(s)
  佐藤颯斗，細井　徹，長谷川由貴，松村奈美，小澤光一郎
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] 病態時におけるグリア-ニューロンインターラクションを介した肥満発症機構の解明―レプチン抵抗性のメカニズムの解明―2020
- Author(s)
  佐藤颯斗，細井　徹，長谷川由貴，松村奈美，小澤光一郎
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] 地域住民の意識調査に基づいた薬局での健康フェア実施方法の模索2020
- Author(s)
  三浦常代，池田佳代，細井徹，吉井美智子，杉山政則，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  第53回日本薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] 薬局の健康フェアに関する広島市域住民の意識調査2020
- Author(s)
  池田佳代，三浦常代，細井徹，吉井美智子，杉山政則，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  第40回広島県薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] ストレス負荷によるグリア細胞からのadenosine遊離と神経細胞におけるレプチン抵抗性形成機構の解析2020
- Author(s)
  和田　萌々恵，松浦　武典，細井　徹，松﨑　周，杉山　礼隆，児玉　尚士，小澤　光一郎
- Organizer
  日本薬学会　第140年会
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] 「健康フェア」における肥満関連遺伝子検査及び東洋医学的解析の活用2020
- Author(s)
  島崎一郎，池田佳代，細井徹，三浦常代，吉井美智子，杉山政則，野村祐仁，豊見雅文，小澤光一郎
- Organizer
  第53回日本薬剤師会学術大会
- Data Source
  KAKENHI-PROJECT-19K10559
[Presentation] Possible involvement of homocysteine on neuronal leptin resistance in obesity2019
- Author(s)
  Arini Isnani Preninka, Toru Hosoi, Michiko Yoshii, Koichiro Ozawa
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 膵臓β細胞のアルツハイマー病関連神経細胞死への影響2019
- Author(s)
  與田優香理，細井　徹，中島　美衣子，松浦武典，小澤　光一郎
- Organizer
  第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] Inhibitory mechanisms of adenosine on the Ob-R receptor mediated leptin signaling.2019
- Author(s)
  Hosoi T., Silva A., Matsuura T., Sugiyama N., Shimizu K., Ozawa K., Jockers R., Dam J.
- Organizer
  CNRS GDR3545 GPCR international meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0463
[Presentation] p62とアミロイド前駆体蛋白質（APP）のC末端断片を発現させたときに起きる凝集体および小胞形成2019
- Author(s)
  藏本滉平，細井　徹，田中景吾，野村靖幸，小澤光一郎
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] フルルビプロフェンの小胞体ストレス軽減効果による糖尿病抑制の可能性2019
- Author(s)
  松浦　武典，細井　徹，松﨑　周，親泊　政一，小澤　光一郎
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-16K08271
[Presentation] フルルビプロフェンのALDH2タンパク質に対する作用の解明2019
- Author(s)
  城田　真輝，細井　徹，森　光平，小澤　孝一郎
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] フルルビプロフェンの小胞体ストレス軽減効果による糖尿病抑制の可能性2019
- Author(s)
  松浦　武典，細井　徹，松﨑　周，親泊　政一，小澤　孝一郎
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 正常ならびに肥満病態時のグリア細胞の神経細胞におけるレプチンシグナルへの役割2018
- Author(s)
  松村　奈美，細井　徹，長谷川　由貴，小澤　孝一郎
- Organizer
  第57回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 膵臓β細胞由来エクソソームの神経細胞死抑制効果の検討2018
- Author(s)
  中島　美衣子，細井　徹，與田優香理，小澤　光一郎
- Organizer
  第134回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18KT0072
[Presentation] FlurbiprofenのALDH2タンパク質活性に対する影響の検討2018
- Author(s)
  城田真輝，細井　徹，森　光平，小澤孝一郎
- Organizer
  第133回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] フルルビプロフェンによるALDH2活性制御機構の解明2018
- Author(s)
  細井　徹，森　光平，城田真輝，小澤孝一郎
- Organizer
  第71回日本酸化ストレス学会・第18回日本NO学会　合同学術集会
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] フルルビプロフェンによるALDH2活性制御機構の解明2018
- Author(s)
  細井　徹，森　光平，城田　真輝，小澤　孝一郎
- Organizer
  第71回日本酸化ストレス学会・第18回日本NO学会　合同学術集会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 正常ならびに肥満病態時のグリア細胞の神経細胞におけるレプチンシグナルへの役割2018
- Author(s)
  松村　奈美，細井　徹，長谷川　由貴，小澤　光一郎
- Organizer
  第57回　日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K08271
[Presentation] FlurbiprofenのALDH2タンパク質活性に対する影響の検討2018
- Author(s)
  城田　真輝，細井　徹，森　光平，小澤　孝一郎
- Organizer
  第133回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06549
[Presentation] 脂肪酸によるレプチン応答性変化の系統的解析2017
- Author(s)
  荻野陽平，田中智洋，金子賢太朗，園山拓洋，Guo Tingting，雲財知，小山博之，青谷大介，今枝憲郎，細井　徹，中尾一和
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-16K08271
[Presentation] レプチン抵抗性形成への4-hydroxy-2-nonenalの関わり2017
- Author(s)
  細井　徹, 桑村彩加, 小澤光一郎
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎市
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-16K08271
[Presentation] Insulin potentiated leptin-induced anti-obesity signal through GRP78 in neurons2017
- Author(s)
  トン・ミナ, 細井　徹, 小澤光一郎
- Organizer
  第131回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K08271
[Presentation] 小胞体ストレス応答シグナルIRE1-XBP1経路に対するプロテインキナーゼCの影響2017
- Author(s)
  森本純加，細井　徹，末澤隆宏，櫨木薫，櫨木　修，小澤光一郎
- Organizer
  第56回　日本薬学会　日本薬剤師会　日本病院薬剤師会　中国四国支部学術大会
- Data Source
  KAKENHI-PROJECT-16K08271
[Presentation] マウスにおけるアルデヒドデヒドロゲナーゼ2欠損による行動異常の発現2016
- Author(s)
  森　光平, 細井　徹, 北川恭子, 小澤　光一郎
- Organizer
  第55回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Place of Presentation
  岡山市
- Year and Date
  2016-11-05
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] 中枢神経系におけるレプチン抵抗性の形成機構解明と創薬ターゲット開発戦略2016
- Author(s)
  細井　徹, 小澤　光一郎
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-09
- Invited
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] レプチン抵抗性による肥満形成機構の解明と創薬開発戦略2016
- Author(s)
  細井　徹, 小澤　光一郎
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Invited
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] Behavioral analysis of ALDH2 deficient mice.2016
- Author(s)
  Hosoi T., Mori K., Kitagawa K., Ozawa K.
- Organizer
  The 18th international symposium of society for Aldh2 knockout research-Joint symposium with 5th prenatal programming and toxicity (PPTox V)
- Place of Presentation
  北九州市
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] 小胞体ストレスを標的とした治療薬開発の可能性2016
- Author(s)
  細井　徹, 小澤　光一郎
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] 小胞体ストレスを標的とした治療薬開発の可能性2016
- Author(s)
  細井徹、小澤孝一郎
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] レプチン抵抗性による肥満形成機構の解明と創薬開発戦略2016
- Author(s)
  細井徹、小澤孝一郎
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] 中枢神経系におけるレプチン抵抗性の形成機構解明と創薬ターゲット開発戦略2016
- Author(s)
  細井徹、小澤孝一郎
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-09
- Invited
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] 神経細胞レプチンシグナルへのグリア細胞の役割2015
- Author(s)
  長谷川由紀, 細井徹, 小澤光一郎
- Organizer
  第54回日本薬学会・日本薬剤師会・日本病院薬剤師会　中国四国支部学術大会
- Place of Presentation
  高知市
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] 小胞体ストレスによるレプチン抵抗性形成機構の解明2015
- Author(s)
  細井徹、小澤孝一郎
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] 小胞体ストレスによるレプチン抵抗性形成機構の解明2015
- Author(s)
  細井　徹, 小澤　光一郎
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  横浜市
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] 神経細胞レプチンシグナルへのグリア細胞の役割2015
- Author(s)
  長谷川由紀、細井徹、小澤孝一郎
- Organizer
  第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高知市
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-15K08025
[Presentation] フルルビプロフェンのアルデヒドデヒドロゲナーゼを介する小胞体ストレス軽減効果2014
- Author(s)
  細井　徹、山口　理恵、野地　紀久子、茅野　貴秋、森　光平、小澤　光一郎
- Organizer
  第87回　日本薬理学会年会
- Place of Presentation
  仙台市
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] 小胞体ストレスを標的とした生活習慣病の新規治療薬開発戦略2014
- Author(s)
  細井　徹
- Organizer
  平成26年度広島医療情報研究会学術講演会
- Place of Presentation
  広島市
- Year and Date
  2014-09-06
- Invited
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] フルルビプロフェンによる小胞体ストレス改善作用機構の解明2014
- Author(s)
  細井　徹、山口　理恵、野地　紀久子、茅野　貴秋、森　光平、小澤　光一郎
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] Flurubiprofen の小胞体ストレス軽減によるレプチン抵抗性・肥満改善効果2014
- Author(s)
  細井　徹, 森　光平, 末澤　隆浩, 馬場　幸子, 豊田　圭亮, 小澤　光一郎
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2014
- Place of Presentation
  大阪市
- Year and Date
  2014-08-31
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] Flurbiprofenのレプチン抵抗性改善作用の解析2013
- Author(s)
  茅野貴秋、細井　徹、山口理恵、野地紀久子、小澤光一郎
- Organizer
  第124回日本薬理学会近畿部会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] 脳内小胞体ストレスによるアルブミン産生とマウス行動への影響2013
- Author(s)
  本田　昌子、細井　徹、小澤光一郎
- Organizer
  第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  松山市
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] 小胞体ストレスを標的とした新規抗肥満薬の探索2013
- Author(s)
  山口理恵、細井徹、馬場幸子、豊田圭亮、野地紀久子、小澤光一郎
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 小胞体ストレスを標的とした新規抗肥満薬の探索2012
- Author(s)
  山口理恵、細井徹、馬場幸子、豊田圭亮、野地紀久子、小澤光一郎
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23790088
[Presentation] 肥満における小胞体ストレス誘導性のレプチン抵抗性改善化合物の探索2012
- Author(s)
  豊田圭亮、細井徹、小澤光一郎
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 肥満における小胞体ストレス誘導性のレプチン抵抗性改善化合物の探索2012
- Author(s)
  豊田圭亮、細井徹、小澤光一郎
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23790088
[Presentation] MyD88遺伝子欠損による糖尿病発症機構の解明～コレステロール合成制御異常の関与～2011
- Author(s)
  横山匠太、細井徹、小澤光一郎
- Organizer
  第120回日本薬理学会近畿部会
- Place of Presentation
  京都市
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23790088
[Presentation] 新機構肥満薬における作用機構の解明2011
- Author(s)
  馬場幸子、細井徹、松尾俊、山口理恵、豊田圭亮、小澤光一郎
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 小胞体ストレスと免疫応答活性化による新規アルツハイマー病発症機構2011
- Author(s)
  細井徹
- Organizer
  日本薬学会第131年会(シンポジウム)
- Place of Presentation
  静岡(招待講演)
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] 肥満脳におけるレプチン受容体応答系抑制機構の解明と創薬:小胞体ストレスの関与2011
- Author(s)
  細井徹、馬場幸子、松尾俊、山口理恵、豊田圭亮、茅野貴秋、大熊康修、野村靖幸、小澤光一郎
- Organizer
  第38回日本脳科学会
- Place of Presentation
  沖縄県那覇市
- Data Source
  KAKENHI-PROJECT-23790088
[Presentation] 小胞体ストレスによるレプチン抵抗性を標的とした生活習慣病に対する創薬ターゲットの探索2011
- Author(s)
  細井徹、馬場幸子、松尾俊、山口理恵、豊田圭亮、茅野貴秋、小澤光一郎
- Organizer
  第6回小胞体ストレス研究会
- Place of Presentation
  岡山市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23790088
[Presentation] 肥満脳におけるレプチン受容体応答系抑制機構の解明と創薬:小胞体ストレスの関与2011
- Author(s)
  細井徹、馬場幸子、松尾俊、山口理恵、豊田圭亮、茅野貴秋、大熊康修、野村靖幸、小澤光一郎
- Organizer
  第38回日本脳科学会
- Place of Presentation
  沖縄県那覇市
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 肥満脳におけるレプチン受容体応答系抑制機構の解明と創薬:小胞体ストレスの関与2011
- Author(s)
  細井徹
- Organizer
  第38回日本脳科学会
- Place of Presentation
  沖縄県那覇市
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] MyD88遺伝子欠損による糖尿病発症機構の解明～コレステロール合成制御異常の関与～2011
- Author(s)
  横山匠太、細井徹、小澤光一郎
- Organizer
  第120回日本薬理学会近畿部会
- Place of Presentation
  京都市
- Year and Date
  2011-01-11
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 生活習慣病の新機構解明と次世代型治療薬の開発研究2011
- Author(s)
  細井徹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] MyD88欠損による新規糖尿病発症メカニズムの解明2011
- Author(s)
  横山匠太、細井徹、松尾俊、審良静男、小澤光一郎
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 小胞体ストレスと免疫応答活性化による新規アルツハイマー病発症機構2011
- Author(s)
  細井徹
- Organizer
  日本薬学会第131年会(シンポジウム)
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 小澤孝一郎小胞体ストレスと免疫応答活性化による新規アルツハイマー病発症機構2011
- Author(s)
  細井徹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] 生活習慣病の新機構解明と次世代型治療薬の開発研究2011
- Author(s)
  細井徹
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡(奨励賞講演招待講演)
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] 小胞体ストレスによるレプチン抵抗性を標的とした生活習慣病に対する創薬ターゲットの探索2011
- Author(s)
  細井徹、馬場幸子、松尾俊、山口理恵、豊田圭亮、茅野貴秋、小澤光一郎
- Organizer
  第6回小胞体ストレス研究会
- Place of Presentation
  岡山市
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 小胞体ストレスを標的とした肥満治療薬の解明2010
- Author(s)
  馬場幸子、細井徹、松尾俊、山口理恵、豊田圭亮、小澤光一郎
- Organizer
  118回日本薬理学会近畿部会
- Place of Presentation
  大阪
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 小澤孝一郎アルツハイマー病発症に関わる小胞体ストレスと免疫応答の新規メカニズム2010
- Author(s)
  細井徹、大庭達哉、本多美耶、大熊康修、野村靖幸
- Organizer
  第37回日本脳科学会
- Place of Presentation
  天津医科大学国際会議センター(中国)
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] Endoplasmic reticulum stress induces leptin resistance.2010
- Author(s)
  Hosoi T.
- Organizer
  Experimental Biology2010
- Place of Presentation
  Anaheim, USA(招待講演)
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] MyD88遺伝子欠損による糖尿病誘発2010
- Author(s)
  細井徹、横山匠太、松尾俊、小澤孝一郎
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] Endoplasmic reticulum stress induces leptin resistance.2010
- Author(s)
  Hosoi T.
- Organizer
  Experimental Biology2010
- Place of Presentation
  Anaheim, USA
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] 感染及び拘束ストレスにより誘発される摂食抑制のメカニズムの解明-視床下部 MyD88/STAT3 経路の関わり-2010
- Author(s)
  木村仁美、山脇洋輔、細井徹、小澤光一郎
- Organizer
  第118回日本薬理学会近畿部会
- Place of Presentation
  大阪
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] アルツハイマー病発症に関わる小胞体ストレスと免疫応答の新規メカニズム2010
- Author(s)
  細井徹
- Organizer
  第37回日本脳科学会
- Place of Presentation
  天津医科大学国際会議センター(中国)
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] 神田稔子, 細井徹, 石口瑞穂, 小澤光一郎2010
- Author(s)
  神田稔子, 細井徹, 石口瑞穂, 小澤光一郎
- Organizer
  第118回日本薬理学会近畿部会
- Place of Presentation
  大阪
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22590100
[Presentation] 肥満の中枢機構:小胞体ストレスによる視床下部レプチン受容体応答活性低下の関与2009
- Author(s)
  細井徹、大熊康修、野村靖幸、小澤孝一郎
- Organizer
  第36回日本脳科学会
- Place of Presentation
  金沢市
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance.2009
- Author(s)
  Hosoi T., Sasaki M., Miyahara T., Hashimoto C., Matsuo S., Yoshii M., Ozawa K.
- Organizer
  The 11th International Symposium on Exocrine Secretion, Tokushima 09
- Place of Presentation
  Tokushima, Japan
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] グリア細胞におけるIL-6産生調節系への小胞体ストレスの関与の可能性2009
- Author(s)
  細井徹、大庭達哉、本多美耶、小澤孝一郎
- Organizer
  第14回グリア研究会
- Place of Presentation
  大阪市
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] Leptin resistance associated with obesity would be mediated througt endoplasmic reticulum stress.2009
- Author(s)
  Hosoi T
- Organizer
  4th Cell Stress Society International (CSSI) Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo, Japan.
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] Possible involvement of endoplasmic reticulum stress in obesity associated with leptin resistance2009
- Author(s)
  Hosoi T
- Organizer
  The 11th International Symposium on Exocrine Secretion, Tokushima 09
- Place of Presentation
  Tokushima, Japan
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] Leptin resistance associated with obesity would be mediated through endoplasmic reticulum stress.2009
- Author(s)
  Hosoi T., Sasaki M., Miyahara T., Hashimoto C., Matsuo S., Yoshii M., Ozawa K.
- Organizer
  4th Cell Stress Society International (CSSI) Congress on Stress Responses in Biology and Medicine
- Place of Presentation
  Sapporo, Japan.
- Data Source
  KAKENHI-PROJECT-21790079
[Presentation] 小胞体ストレスによるレプチン抵抗性のメカニズムの解明2008
- Author(s)
  細井徹
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] 小胞体ストレスによるレプチン抵抗性のメカニズム〜SOCS 3およびPTP1Bの関与の検討〜2008
- Author(s)
  細井徹
- Organizer
  第82回薬理学会年会
- Place of Presentation
  横浜市
- Year and Date
  2008-03-16
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] 肥満とレプチン2008
- Author(s)
  細井徹
- Organizer
  第62回広島医療情報研究会
- Place of Presentation
  広島市
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] 肥満とレプチン2008
- Author(s)
  細井徹
- Organizer
  第63回広島医療情報研究会
- Place of Presentation
  広島市
- Year and Date
  2008-08-02
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] レプチンシグナルにおよぼす小胞体ストレスの影響2008
- Author(s)
  細井徹、佐々木珠也子、橋本千恵、宮原強、松尾俊、吉井美智子、小澤光一郎
- Organizer
  第47回中国四国支部学術大会
- Place of Presentation
  岡山市
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] 小胞体ストレスによるレプチンシグナルへの影響〜SOCS3 およびPTP1B の関与の検討〜2008
- Author(s)
  細井徹、佐々木珠也子、橋本千恵、宮原強、松尾俊、吉井美智子、小澤光一郎
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] 小胞体ストレスによるレプチン抵抗性のメカニズムの解明2008
- Author(s)
  細井徹、佐々木珠也子、橋本千恵、宮原強、松尾俊、吉井美智子、小澤光一郎
- Organizer
  第81 回日本薬理学会年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] レプチンシグナルにおよぼす小胞体ストレスの影響2008
- Author(s)
  細井徹
- Organizer
  第47回中国四国支部学術大会
- Place of Presentation
  岡山市
- Year and Date
  2008-11-09
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] 小胞体ストレスのレプチン抵抗性への関与の可能性2007
- Author(s)
  細井徹、小澤光一郎
- Organizer
  日本薬学会第127年会
- Place of Presentation
  富山市
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] レプチンシグナルにおよぼす小胞体ストレスの影響2007
- Author(s)
  細井徹、橋本千恵、宮原強、吉井美智子、小澤光一郎
- Organizer
  第80回日本薬理学会年会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-19790059
[Presentation] 肥満脳におけるレプチン受容体応答系抑制機構の解明と創薬：小胞体ストレスの関与
- Author(s)
  細井徹
- Organizer
  第３8回　日本脳科学会
- Place of Presentation
  沖縄県那覇市
- Data Source
  KAKENHI-PROJECT-23790088
[Presentation] 小胞体ストレスによる生活習慣病発症機構解明と創薬
- Author(s)
  細井　徹,小澤　光一郎
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸市
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] 小胞体ストレスによるレプチン抵抗性を標的とした生活習慣病に対する創薬ターゲットの探索
- Author(s)
  細井徹
- Organizer
  第６回小胞体ストレス研究会
- Place of Presentation
  岡山市
- Data Source
  KAKENHI-PROJECT-23790088
[Presentation] 小胞体ストレスによるレプチン抵抗性・肥満形成機構とその制御薬の探索
- Author(s)
  細井　徹, 森　光平, 末澤　隆浩, 馬場　幸子, 豊田　圭亮, 小澤　光一郎
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜市
- Year and Date
  2014-11-25 – 2014-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-25460101
[Presentation] 小胞体ストレスによるレプチン抵抗性のflurbiprofenによる改善効果
- Author(s)
  細井　徹, 山口　理恵, 馬場　幸子, 森　光平, 豊田　圭亮, 茅野　貴秋, 小澤　光一郎
- Organizer
  第9回小胞体ストレス研究会
- Place of Presentation
  徳島市
- Year and Date
  2014-07-04 – 2014-07-05
- Data Source
  KAKENHI-PROJECT-25460101

1. OZAWA Koichiro (10211822)

# of Collaborated Projects: 5 results

# of Collaborated Products: 63 results
2. TAKEDA Kei (30135032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 杉山政則 (30106801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 池田佳代 (30379911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
5. 吉井美智子 (40230677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
6. 柳瀬雄輝 (40452586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 中川直 (30707013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 野田泰裕 (90880336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 山脇洋輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 古武弥一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 太田茂

# of Collaborated Projects: 0 results

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12. 田原栄俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 大熊康修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 野村靖幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hosoi Toru 細井 徹

HOSOI Toru 細井 徹

Research Projects

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肥満制御の新機構解明―細胞膜と小胞体のクロストークによる制御―Principal Investigator

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Do Food Additives Cause Obesity?-Elucidation of the mechanism of action on leptin receptor signaling-Principal Investigator

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The role of ER stress proteins for mast cell functions

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Elucidation of the molecular mechanisms and treatment against physiological factor/ER stress-induced obesity/metabolic syndromePrincipal Investigator

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Elucidation of the strategy towards the healthy life expectancy stretching by the use of big data

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Prediction of disease progression by analyzing endoplasmic reticulum stress sensor systemPrincipal Investigator

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ER stress-induced leptin resistance and epigenetic mechanisms in regulating obesity

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Elucidation of the mechanisms and pharmacological target for metabolic syndrome by analyzing endoplasmic reticulum stress, which is mediated through physiological factor and cell-to-cell communicationPrincipal Investigator

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Elucidation of novel therapeutics of endoplasmic reticulum stress-related disease targeting aldehyde dehydrogenase

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Elucidation of the treatment against metabolic syndrome by regulating endoplasmic reticulum functionPrincipal Investigator

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Novel therapy for metabolic syndrome targeting ER stressPrincipal Investigator

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Development of novel drug for obesity targeting endoplasmic reticulum stress

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Elucidation of novel mechanisms of obesity and the therapeutic drug -elucidation of leptin resistance-Principal Investigator

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Hosoi Toru 細井徹

HOSOI Toru 細井徹