Sakamoto Taiichi 坂本泰一

… Alternative Names

坂本泰一サカモトタイイチ

SAKAMOTO Taiichi 坂本泰一

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Researcher Number	40383369
Other IDs	https://orcid.org/0000-0002-1450-9372
Affiliation (Current)	2023: 千葉工業大学, 先進工学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2022: 千葉工業大学, 先進工学部, 教授 2015: 千葉工業大学, 工学部, 教授 2011 – 2012: 千葉工業大学, 工学部, 准教授 2008: Chiba Institute of Technology, 工学部, 准教授 2007: Chiba Institute of Technology, 工学部, 助教 2006: 千葉工業大学, 工学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Biological Sciences / Structural biochemistry Except Principal Investigator Basic Section 43020:Structural biochemistry-related / Basic Section 62010:Life, health and medical informatics-related / Basic Section 57050:Prosthodontics-related / Structural biochemistry
Keywords	Principal Investigator NMR / 論理的設計 / 物理化学的解析 / 構造解析 / 線維芽細胞増殖因子 / FGF / アプタマー / 急性骨髄性白血病 / AML1タンパク質 / RNAアプタマー … More / RNA / タンパク質 / 構造生物学 / シグナル認識粒子 / 機能性RNA / 核酸 … More Except Principal Investigator NMR / 核酸 / フラグメント分子軌道計算 / 分子動力学計算 / 分子シミュレーション / RNAアプタマー / pre-mRNAスプライシング / VIINEC / フラグメント分子軌道法 / アプタマー / U2 snRNP / チタン / インプラント周囲炎 / オッセオインテグレーション / リボプロテオミクス / 構造解析 / 質量分析 / Xist / X線結晶構造解析 / SHARP / 遺伝子量補償 / 分子認識 / シミュレーション / 計算化学 / mRNAスプライシング / SELEX / がん / スプライシング Less

RNAアプタマーを利用したU2 snRNPの「ゆるい」ブランチ部位認識機構の解明
- Principal Investigator
  
  桑迫香奈子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Musashino University
分子シミュレーションによる新規RNAアプタマー設計の基盤技術の構築
- Principal Investigator
  
  山岸賢司
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Nihon University
繊維芽細胞増殖因子FGF5と受容体の相互作用およびアプタマーの阻害機序の解明Principal Investigator
- Principal Investigator
  
  坂本泰一
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Chiba Institute of Technology
遺伝子情報に基づいたインプラント周囲炎の画期的治療法の開発
- Principal Investigator
  
  堀内留美
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57050:Prosthodontics-related
- Research Institution
  Hokkaido University
A multidisciplinary approach to establish the structural basis of dosage compensation
- Principal Investigator
  
  Mishima Masaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Tokyo University of Pharmacy and Life Science
  Tokyo Metropolitan University
Molecular Recognition Mechanism of RNA aptamer
- Principal Investigator
  
  YAMAGISHI Kenji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Nihon University
Structural study of human spliceosomal protein SF3b1
- Principal Investigator
  
  Kuwasako Kanako
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Musashino University
急性骨髄性白血病の原因タンパク質ＡＭＬ１とＲＮＡアプタマーの複合体の構造解析Principal Investigator
- Principal Investigator
  
  坂本泰一
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Chiba Institute of Technology
Structural analysis of signal recognition particlePrincipal Investigator
- Principal Investigator
  
  SAKAMOTO Taiichi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Chiba Institute of Technology

All 2021 2020 2019 2018 2017 2016 2013 2012 2011 2009 2008 2006

All Journal Article Presentation Book

[Book] RNA Chaperones - Methods and Protocols, "Kinetic and Thermodynamic Analyses of RNA Protein Interactions"2020
- Author(s)
  Amano Ryo, Sakamoto Taiichi
- Total Pages
  310
- Publisher
  Humana Press
- ISBN
  9781071602317
- Data Source
  KAKENHI-PROJECT-18K11536
[Book] 医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略, "核酸医薬品の構造と物理化学的特性の解析-核酸医薬品の論理的な開発を目指して-"2019
- Author(s)
  坂本泰一
- Total Pages
  206
- Publisher
  情報機構
- ISBN
  9784865021769
- Data Source
  KAKENHI-PROJECT-18K11536
[Book] Encyclopedia of Systems Biology2013
- Author(s)
  Taiichi Sakamoto
- Publisher
  Springer
- Data Source
  KAKENHI-PUBLICLY-23121528
[Book] 機能性Non-coding RNA2006
- Author(s)
  河合剛太,坂本泰一
- Publisher
  クバプロ
- Data Source
  KAKENHI-PROJECT-18570113
[Journal Article] Amelioration of Alzheimer’s Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model2021
- Author(s)
  Minamisawa Mayumi、Sato Yuma、Ishiguro Eitarou、Taniai Tetsuyuki、Sakamoto Taiichi、Kawai Gota、Saito Takashi、Saido Takaomi C.
- Journal Title
  
  Life
  
  Volume: 12 Issue: 1 Pages: 34-34
- DOI
  10.3390/life12010034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06529, KAKENHI-PROJECT-21K12129
[Journal Article] The N93D mutation of the human T-cell leukemia virus type 1 envelope glycoprotein found in symptomatic patients enhances neuropilin-1 b1 domain binding2021
- Author(s)
  Kusunoki Hideki、Tanaka Toshiyuki、Ohshima Chinatsu、Sakamoto Taiichi、Wakamatsu Kaori、Hamaguchi Isao
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: 1869 Issue: 11 Pages: 140708-140708
- DOI
  10.1016/j.bbapap.2021.140708
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06529, KAKENHI-PROJECT-21K12129
[Journal Article] Specific Inhibition of FGF5-induced Cell Proliferation by RNA Aptamers2021
- Author(s)
  Amano, R., Namekata, M., Horiuchi, M., Saso, M., Yanagisawa, T., Tanaka, Y., Ghani, F.I., Yamamoto, M., Sakamoto T.
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 2976-2976
- DOI
  10.1038/s41598-021-82350-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06529, KAKENHI-PROJECT-20K15406, KAKENHI-PROJECT-17K05936, KAKENHI-PROJECT-18K11536
[Journal Article] Altered‐specificity mutants of the HIV Rev arginine‐rich motif‐RRE IIB interaction2020
- Author(s)
  Raad Nicole G., Ghattas Ingrid R., Amano Ryo, Watanabe Natsuki, Sakamoto Taiichi, Smith Colin A.
- Journal Title
  
  Journal of Molecular Recognition
  
  Volume: 33(6) Issue: 6
- DOI
  10.1002/jmr.2833
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11536
[Journal Article] A G-quadruplex-forming RNA aptamer binds to the MTG8 TAFH domain and dissociates the leukemic AML1-MTG8 fusion protein from DNA2020
- Author(s)
  Fukunaga, J., Nomura, Y., Tanaka, Y., Torigoe, H., Nakamura, Y., Sakamoto, T., Kozu, T.
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 21 Pages: 3477-3489
- DOI
  10.1002/1873-3468.13914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06529, KAKENHI-PROJECT-18K11536
[Journal Article] Binding interaction analysis of RNA aptamer-Fc region of human immunoglobulin G using fragment molecular orbital calculation2020
- Author(s)
  Yoshida Hisae, Sato Koki, Ishikawa Takeshi, Sakamoto Taiichi, Yamagishi Kenji
- Journal Title
  
  Chemical Physics Letters
  
  Volume: 738 Pages: 136854-136854
- DOI
  10.1016/j.cplett.2019.136854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11536, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-17J01992
[Journal Article] Crystal structure and calcium-induced conformational changes of diacylglycerol kinase α EF-hand domains2019
- Author(s)
  Takahashi Daisuke、Suzuki Kano、Sakamoto Taiichi、Iwamoto Takeo、Murata Takeshi、Sakane Fumio
- Journal Title
  
  Protein Science
  
  Volume: 28 Issue: 4 Pages: 694-706
- DOI
  10.1002/pro.3572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11536, KAKENHI-PROJECT-17H03650, KAKENHI-PROJECT-17K15444, KAKENHI-PROJECT-19K06527
[Journal Article] Elucidation of the Role of Ca<sup>2+</sup> in the Formation of an RNA Aptamer/Human Immunoglobulin G Complex Using Molecular Dynamics Simulation2019
- Author(s)
  Ishii Seiichiro, Sekiguchi Masahiro, Yoshida Hisae, Masukawa Keisuke, Ishikawa Takeshi, Sakamoto Taiichi, Yamagishi Kenji
- Journal Title
  
  J. Comput. Chem. Jpn.
  
  Volume: 18 Issue: 5 Pages: 208-210
- DOI
  10.2477/jccj.2019-0051
- NAID
  130007815004
- ISSN
  1347-1767, 1347-3824
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11536, KAKENHI-PROJECT-17J01992
[Journal Article] Synthesis of 4′- C -aminoalkyl-2′- O -methyl modified RNA and their biological properties2018
- Author(s)
  Koizumi Kana、Maeda Yusuke、Kano Toshifumi、Yoshida Hisae、Sakamoto Taiichi、Yamagishi Kenji、Ueno Yoshihito
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 12 Pages: 3521-3534
- DOI
  10.1016/j.bmc.2018.05.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11536, KAKENHI-PROJECT-17J01992
[Journal Article] Development of Aptamer Therapeutics and Structural Biology2018
- Author(s)
  SAKAMOTO Taiichi
- Journal Title
  
  Nihon Kessho Gakkaishi
  
  Volume: 60 Issue: 2-3 Pages: 129-134
- DOI
  10.5940/jcrsj.60.129
- NAID
  130007383392
- ISSN
  0369-4585, 1884-5576
- Year and Date
  2018-05-31
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-18K11536
[Journal Article] Polyamines stimulate the CHSY1 synthesis through the unfolding of the RNA G-quadruplex at the 5′-untraslated region2018
- Author(s)
  Yamaguchi Katsutoshi、Asakura Kiryu、Imamura Masataka、Kawai Gota、Sakamoto Taiichi、Furihata Tomomi、Linhardt Robert J.、Igarashi Kazuei、Toida Toshihiko、Higashi Kyohei
- Journal Title
  
  Biochemical Journal
  
  Volume: 475 Issue: 23 Pages: 3797-3812
- DOI
  10.1042/bcj20180672
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06652, KAKENHI-PROJECT-18K11536
[Journal Article] Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment2017
- Author(s)
  Kuwasako, K.
- Journal Title
  
  Protein Science
  
  Volume: 26 Issue: 2 Pages: 280-290
- DOI
  10.1002/pro.3080
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01548, KAKENHI-PROJECT-16H04756, KAKENHI-PROJECT-15K06945, KAKENHI-PROJECT-15K06970, KAKENHI-PROJECT-15K06982, KAKENHI-PROJECT-17K07312
[Journal Article] Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA2009
- Author(s)
  Haraguchi Y., Kuwasako K., Muto Y., Bessho Y., Nishimoto M., Yokoyama S., Kanai A., Kawai G., Sakamoto T.
- Journal Title
  
  Nucleic Acids Symp. Ser. in press
- Data Source
  KAKENHI-PROJECT-18570113
[Journal Article] NMRによるRNAの立体構造解析2006
- Author(s)
  坂本泰一
- Journal Title
  
  分光研究 55巻
  
  Pages: 173-181
- NAID
  10016976875
- Data Source
  KAKENHI-PROJECT-18570113
[Journal Article] Solution Structure of a GAAG Tetraloop in Helix 6 of SRP RNA from Pyrococcus furiosus, Nucleosides2006
- Author(s)
  Okada K., Takahashi M, Sakamoto T., Kawai G., Nakamura K., Kanai A.
- Journal Title
  
  Nucleotides and Nucleic Acids 25
  
  Pages: 383-395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18570113
[Presentation] NMR Analysis of Interaction between Artificial Peptides and RNAs Derived from HIV-1 Rev and RRE RNA2021
- Author(s)
  Taiichi Sakamoto, Takashi Nagata, Risa Koji, Tae Maeda, Yumi Takeda, Naohiro Kobayashi, Peter Guntert, Masato Katahira, Colin A. Smith, Kazuo Harada
- Organizer
  ISMAR-APNMR-NMRSJ-SEST 2021
- Data Source
  KAKENHI-PROJECT-20K06529
[Presentation] 核酸医薬のNMR2021
- Author(s)
  坂本泰一
- Organizer
  2021年度日本分光学会NMR分光部会集中講義
- Invited
- Data Source
  KAKENHI-PROJECT-21K12129
[Presentation] アプタマー研究におけるITC2021
- Author(s)
  坂本泰一
- Organizer
  MICROCAL ITCワークショップ2021
- Invited
- Data Source
  KAKENHI-PROJECT-20K06529
[Presentation] アプタマーのPEG付加の影響についてのNMR解析2021
- Author(s)
  坂本泰一
- Organizer
  日本核酸医薬学会第6回年会
- Data Source
  KAKENHI-PROJECT-20K06529
[Presentation] デオキシリボヌクレオチドとリボヌクレオチドの違いによるIgG アプタマーの結合プロファイルの解析2021
- Author(s)
  山崎凌司, 金田一樹, 吉田尚恵, 坂本泰一, 石川岳志, 山岸賢司
- Organizer
  化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-21K12129
[Presentation] RNAアプタマーのDNA置換の物理化学的解析2021
- Author(s)
  坂本泰一，山岸賢司
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K12129
[Presentation] 分子シミュレーションを用いたヒト抗体(IgG)に特異的に結合する新規修飾アプタマーの分子設計2021
- Author(s)
  金田一樹, 石井清一郎, 坂本泰一, 石川岳志, 山岸賢司
- Organizer
  化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-21K12129
[Presentation] 標的タンパク質とアプタマーの結合の生物物理学的解析2021
- Author(s)
  坂本泰一
- Organizer
  第2回Aptamer Seminar in Tokyo
- Invited
- Data Source
  KAKENHI-PROJECT-20K06529
[Presentation] 核酸医薬のNMR2021
- Author(s)
  坂本泰一
- Organizer
  日本分光学会NMR分光部会集中講義
- Invited
- Data Source
  KAKENHI-PROJECT-20K06529
[Presentation] ポリアミン・ゆず種子抽出物の食餌による中枢神経変性疾患モデルマウスの病態抑制に向けた腸内免疫グロブリンA（IgA）と腸内細菌の相互作用に関する研究2020
- Author(s)
  笠原希，佐藤佑真，坂本泰一，南澤麿優覽
- Organizer
  日本ポリアミン学会第11回年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Vif-CBFβ-CUL5-ELOB-ELOC複合体に結合するアプタマーのNMR解析2020
- Author(s)
  熊谷紀志，鈴木拓也，関川湧斗，神庭圭介，万里，永田佳代子，高折晃史，片平正人，永田崇，坂本泰一
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-20K06529
[Presentation] ポリアミン・ゆず種子抽出物の食餌による中枢神経変性疾患モデルマウスの病態抑制に向けた腸内環境の研究～次世代シークエンスを用いたマウス腸内細菌叢解析に及ぼす細菌由来DNA抽出条件の影響～2020
- Author(s)
  佐藤佑真，笠原希，石黒栄太郎，坂本泰一，南澤麿優覽
- Organizer
  日本ポリアミン学会第11回年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Vif-CBFβ-CUL5-ELOB-ELOC複合体に結合するアプタマーのNMR解析2020
- Author(s)
  熊谷紀志，鈴木拓也，関川湧斗，神庭圭介，万里，永田佳代子，高折晃史，片平正人，永田崇，坂本泰一
- Organizer
  第59回NMR討論会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 線維芽細胞増殖因子5（FGF5）に対するAptamerアプタマーの解析2020
- Author(s)
  笹生みなみ，天野亮，行方昌人，堀内正隆，柳澤拓也，西本翔，田中陽一郎，GHANI Farhana Ishrat，山本昌邦，坂本泰一
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K06529
[Presentation] NMR analysis for the development of artificial RNAs to control biomolecular functions2020
- Author(s)
  Kazuyuki Kumagai, Takuya Suzuki, Yuto Sekikawa, Keisuke Kamba, Li Wan, Kayoko Nagata, Akifumi Takaori-Kondo, Masato Katahira, Takashi Nagata, Taiichi Sakamoto
- Organizer
  The 11th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 線維芽細胞増殖因子5（FGF5）に対するAptamerアプタマーの解析2020
- Author(s)
  笹生みなみ，天野亮，行方昌人，堀内正隆，柳澤拓也，西本翔，田中陽一郎，GHANI Farhana Ishrat，山本昌邦，坂本泰一
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] NMR analysis for the development of artificial RNAs to control biomolecular functions2020
- Author(s)
  Kazuyuki Kumagai, Takuya Suzuki, Yuto Sekikawa, Keisuke Kamba, Li Wan, Kayoko Nagata, Akifumi Takaori-Kondo, Masato Katahira, Takashi Nagata, Taiichi Sakamoto
- Organizer
  The 11th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06529
[Presentation] Molecular Dynamics Simulation of the Effect that Ca2+ has on the Tertiary Structure of an RNA Aptamer2020
- Author(s)
  Kazuki Kaneda, Seiichiro Ishii, Hisae Yoshida, Takeshi Ishikawa, Taiichi Sakamoto, Kenji Yamagishi
- Organizer
  第２０回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 分子シミュレーションによるRNAアプタマー- IgG複合体の相互作用解析および複合体形成におけるCa2+の影響2019
- Author(s)
  石井清一郎，吉田尚恵，増川恵介，石川岳志，坂本泰一，山岸賢司
- Organizer
  日本コンピュータ化学会2019秋季年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Development of RNAs that bind to the Vif - CBFβ - CUL 5 - ELOB - ELOC complex2019
- Author(s)
  Kumagai Kazuyuki, Suzuki Takuya, Sekikawa Yuto, Kamba Keisuke, Wan Li, Nagata Kayoko, Takaori-Kondo Akifumi, Katahira Masato, Nagata Takashi, Sakamoto Taiichi
- Organizer
  The 10th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 分子動力学計算によるIgGアプタマーの構造特性の解析2019
- Author(s)
  石井清一郎, 吉田尚恵, 増川恵介, 矢田部優貴, 秋田一雅, 猪股恵美礼, 石川岳志, 坂本泰一, 山岸賢司
- Organizer
  日本化学会第99回春季大会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Vif - CBFβ - CUL5 - ELOB - ELOC 複合体に結合するアプタマーの解析2019
- Author(s)
  熊谷紀志，鈴木拓也，関川湧斗，神庭圭介，万里，永田佳代子，高折晃史，片平正人，永田崇，坂本泰一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] In-cell NMR法によるヒト生細胞内における核酸‐リガンド相互作用観測の解析2019
- Author(s)
  高見昇平，山置佑大，加納ふみ，村田昌之，坂本秦一，原田和雄，永田崇，片平正人
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Vif - CBFβ - CUL5 - ELOB - ELOC 複合体と2'F 修飾aptamerの相互作用解析2019
- Author(s)
  関川湧斗，横山達摩，河村伶美，神庭圭介，万里，永田佳代子，高折晃史，片平正人，永田崇，坂本泰一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] マウス腸内細菌叢解析のための細菌由来DNA抽出条件と測定方法の比較2019
- Author(s)
  佐藤佑真，坂本泰一，南澤麿優覽
- Organizer
  日本分析化学会第86年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Combined computational and experimental study on the binding mechanism of RNA aptamer to human Immunoglobulin G2019
- Author(s)
  Masukawa Keisuke, Yoshida Hisae, Ishii Seiichiro, Yatabe Yuuki, Ishikawa Takeshi, Sakamoto Taiichi, Yamagishi Kenji
- Organizer
  CBI（情報計算化学生物）学会2019年大会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] AML1タンパク質とアプタマーの複合体のX線結晶構造解析2019
- Author(s)
  田川恭志郎，杉山成，天野亮，神津知子，坂本泰一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 抗体に結合するアプタマーと金属イオンの相互作用解析2019
- Author(s)
  古峰真樹，吉田尚恵，関口真裕，石川岳志，山岸賢司，坂本泰一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Selection and characterization of aptamers against fibroblast growth factor (FGF) 52019
- Author(s)
  Saso Minami, Amano Ryo, Namekata Masato, Horiuchi Masataka, Yanagisawa Takuya, Nishimoto Kakeru, Tanaka Yoichiro, Ghani Farhana Ishrat, Yamamoto Masakuni, Sakamoto Taiichi
- Organizer
  The 46th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] AML1 アプタマーの動的構造と結合親和性との相関2019
- Author(s)
  田中淳，増川恵介，吉田尚恵，石川岳志，坂本泰一，山岸賢司
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] RNA アプタマーと標的分子の結合メカニズムの解明2019
- Author(s)
  増川恵介，吉田尚恵，田中淳，石井清一郎，矢田部優貴，石川岳志，坂本泰一，山岸賢司
- Organizer
  第19回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] SELEX実験におけるGRPタグの利用2019
- Author(s)
  大久保広稀，天野亮，堀内正隆，坂本泰一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] PEGを付加したアプタマーのNMR解析2019
- Author(s)
  坂本泰一
- Organizer
  第58回ＮＭＲ討論会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 新規RNAアプタマーの設計を目指したRNAアプタマーと標的分子との結合メカニズム解析2019
- Author(s)
  増川恵介，吉田尚恵，石井清一郎，矢田部優貴，石川岳志，坂本泰一，山岸賢司
- Organizer
  RNAフロンティアミーティング 2019
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 線維芽細胞増殖因子（FGF）5に対するアプタマーの取得と解析2019
- Author(s)
  笹生みなみ，天野亮，行方昌人，堀内正隆，柳澤拓也，西本翔，田中陽一郎，Farhana Ishrat Ghani，山本昌邦，坂本泰一
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Development of functional peptides that bind to RNA2018
- Author(s)
  Natsuki Watanabe, Tomoaki Kinase, Yusuke Nomura, Takashi Nagata, Masato Katahira, Kazuo Harada, Taiichi Sakamoto
- Organizer
  The 9th International Symposium of Advanced Energy Science
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Vif - CBFβ - CUL5 - ELOB - ELOC複合体に対するアプタマーの取得と解析2018
- Author(s)
  鈴木拓也，万里，関川湧斗，田中陽一郎，神庭圭介，片平正人，永田崇，坂本泰一
- Organizer
  平成30年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] siRNAを安定化するカチオン性分子と二本鎖RNAのNMRによる相互作用解析2018
- Author(s)
  坂本泰一，原倫太朗，前田雄介，和田猛
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] HIV-1 RRE由来のRNA断片と人工ペプチドの相互作用の解析2018
- Author(s)
  野村祐介，渡邊なつき，木名瀬智章，永田崇，片平正人，原田和雄，坂本泰一
- Organizer
  第20回日本RNA学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 核酸アプタマーの医療への応用～核酸医薬品から機能性材料まで～2018
- Author(s)
  坂本泰一
- Organizer
  Active agingを支援するバイオメディカル工学の研究拠点
- Invited
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] 抗体に結合する化学修飾アプタマーの熱力学的解析2018
- Author(s)
  矢田部優貴・吉田尚恵・関口真裕・秋田一雅・猪股恵美礼・野村祐介・石川岳志・山岸賢司・坂本泰一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Vif - CBFβ - CUL5 - ELOB - ELOC 複合体に対するアプタマーの取得と解析2018
- Author(s)
  鈴木拓也，万里，関川湧斗，田中陽一郎，神庭圭介，片平正人，永田崇，坂本泰一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] New biophysical approaches to study IRES/ribosome interactions2018
- Author(s)
  Emma Schenckbecher, Benoit Meyer, Guillaume Bec, Taiichi Sakamoto, Philippe Dumas, Eric Ennifar
- Organizer
  RNA2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] スプライシング因子の複合体に結合するaptamerの結合能の解析2018
- Author(s)
  佐藤謙太郎，柳澤拓也，瀧澤将行，天野亮，武藤裕，桑迫香奈子，坂本泰一
- Organizer
  2018年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] スプライシング因子の複合体に結合するaptamerの特性解析2018
- Author(s)
  佐藤謙太郎，柳澤拓也，瀧澤将行，天野亮，武藤裕，桑迫香奈子，坂本泰一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] スプライシング因子の複合体に結合するaptamerの特性解析2018
- Author(s)
  佐藤謙太郎，柳澤拓也，瀧澤将行，天野亮，武藤裕，桑迫香奈子，坂本泰一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] Vif - CBFβ - CUL5 - ELOB - ELOC 複合体に結合する2’F 化した aptamer の取得2018
- Author(s)
  関川湧斗，水澤果那，神庭圭介，鈴木拓也，万里，片平正人，永田崇，坂本泰一
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] スプライシング因子の複合体に結合するaptamerの結合能の解析2018
- Author(s)
  佐藤謙太郎，柳澤拓也，瀧澤将行，天野亮，武藤裕，桑迫香奈子，坂本泰一
- Organizer
  平成30年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] MECHANISM OF MOLECULAR RECOGNITION OF RNA APTAMER TO HUMAN IMMUNOGLOBULIN G2018
- Author(s)
  Hisae YOSHIDA, Takeshi ISHIKAWA, Taiichi SAKAMOTO, Kenji YAMAGISHI
- Organizer
  EFMC-ISMC 2018[XXV EFMC International Symposium on Medicinal Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11536
[Presentation] スプライシング因子の複合体に対するaptamerの取得と解析2017
- Author(s)
  柳澤拓也，桑迫香奈子，徳田正明，天野亮，武藤裕，坂本泰一
- Organizer
  平成29年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] Selection of RNA sequences that bind to a complex of splicing factors.2017
- Author(s)
  柳澤拓也，桑迫香奈子，天野亮，瀧澤将行，武藤裕，坂本泰一
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] Solution structures of the two RNA recognition motif (RRM) domains of the human spliceosomal protein SF3b49.2016
- Author(s)
  Kanako Kuwasako, Kengo Tsuda, Mari Takahashi, Atsuko Sato, Naoya Tochio, Makoto Inoue, Takaho Terada, Takanori Kigawa, Naohiro Kobayashi, Mikako Shirouzu, Takuhiro Ito, Taiichi Sakamoto, Nobukazu Nameki, Kaori Wakamatsu, Peter Guntert, Seizo Takahashi, Shigeyuki Yokoyama, Yutaka Muto
- Organizer
  18th Annual Meeting (21st Annual Meeting of the RNA Society)
- Place of Presentation
  Kyoto International Conference Center
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] In vitro selection of RNA aptamers to a splicing factor.2016
- Author(s)
  Takuya Yanagisawa, Kanako Kuwasako, Ryo Amano, Yutaka Muto, Taiichi Sakamoto
- Organizer
  18th Annual Meeting (21st Annual Meeting of the RNA Society)
- Place of Presentation
  Kyoto International Conference Center
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06982
[Presentation] NMR analysis of the interaction between AML1 (RUNX1) Runt domain and RNA aptamer2012
- Author(s)
  Taiichi Sakamoto et al.
- Organizer
  International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Lyon, France
- Year and Date
  2012-08-19
- Data Source
  KAKENHI-PUBLICLY-23121528
[Presentation] A Structural Motif of RNA Aptamer That Mimics DNA for AML1 Runt Domain2011
- Author(s)
  坂本泰一, 他
- Organizer
  The 16^<th> Annual Meeting of the RNA Society
- Place of Presentation
  国立京都国際会館(京都府)
- Year and Date
  2011-06-15
- Data Source
  KAKENHI-PUBLICLY-23121528
[Presentation] 超好熱性古細菌Pyrococcus furiosusのSRPの構造解析2008
- Author(s)
  助川伸也,岡田潔,高橋真梨,中村幸治,金井昭夫,河合剛太,坂本泰一
- Organizer
  平成20年度日本生化学会関東支部例会
- Place of Presentation
  群馬大学(桐生)
- Year and Date
  2008-06-21
- Data Source
  KAKENHI-PROJECT-18570113
[Presentation] 超好熱性古細菌Pyrococcus furiosusのSRPの構造と機能の解析2006
- Author(s)
  松田崇志,高橋真梨,越智丈衆,助川伸也,岡田潔,中村幸治,金井昭夫,坂本泰一,河合剛太
- Organizer
  第7回極限環境微生物学会年会
- Place of Presentation
  明治大学(川崎)
- Year and Date
  2006-11-29
- Data Source
  KAKENHI-PROJECT-18570113

1. Kuwasako Kanako (10568736)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. YAMAGISHI Kenji (90460021)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
3. 石川岳志 (80505909)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
4. 堀内正隆 (90322825)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. KAWAI Gota (70211860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. Mishima Masaki (70346310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉村明 (70302164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田岡万悟 (60271160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤原俊伸 (80362804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 杉山成 (90615428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 堀内留美 (10374274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 横山敦郎 (20210627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 東恭平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakamoto Taiichi 坂本 泰一

坂本 泰一 サカモト タイイチ

SAKAMOTO Taiichi 坂本 泰一

Research Projects

Research Products

Co-Researchers

RNAアプタマーを利用したU2 snRNPの「ゆるい」ブランチ部位認識機構の解明

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分子シミュレーションによる新規RNAアプタマー設計の基盤技術の構築

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繊維芽細胞増殖因子FGF5と受容体の相互作用およびアプタマーの阻害機序の解明Principal Investigator

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遺伝子情報に基づいたインプラント周囲炎の画期的治療法の開発

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A multidisciplinary approach to establish the structural basis of dosage compensation

Principal Investigator

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Molecular Recognition Mechanism of RNA aptamer

Principal Investigator

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Structural study of human spliceosomal protein SF3b1

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急性骨髄性白血病の原因タンパク質ＡＭＬ１とＲＮＡアプタマーの複合体の構造解析Principal Investigator

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Structural analysis of signal recognition particlePrincipal Investigator

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[Book] RNA Chaperones - Methods and Protocols, "Kinetic and Thermodynamic Analyses of RNA Protein Interactions"2020

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[Book] 医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略, "核酸医薬品の構造と物理化学的特性の解析-核酸医薬品の論理的な開発を目指して-"2019

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[Book] Encyclopedia of Systems Biology2013

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[Book] 機能性Non-coding RNA2006

Author(s)

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Sakamoto Taiichi 坂本泰一

坂本泰一サカモトタイイチ

SAKAMOTO Taiichi 坂本泰一