SHIRAISHI Munehiro 白石宗大

Researcher Number	40389458
Other IDs
Affiliation (based on the past Project Information) *help	2007: University of Occupational and Environmental Health, Japan, School of medicine, researcher 2006 – 2007: 産業医科大学, 医学部, 非常勤助手 2006: 産業医科大学, 医学部, 非常勤医師 2004 – 2005: UOEH, School of medicine, instructor, 医学部, 助手
Review Section/Research Field	Principal Investigator Anesthesiology/Resuscitation studies Except Principal Investigator Anesthesiology/Resuscitation studies / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator 電位依存性ナトリウムチャネル / アルファキサロン / アフリカツメガエル卵母細胞 / 電立性ナトリムチネル / デクスメデトミジン / アルフキサロン / トラマドール / 吸入麻酔薬 Except Principal Investigator 麻酔薬 / アフリカツメガエル卵母細胞発現系 … More / 吸入麻酔薬 / エンフルラン / イソフルラン / Dexmedetomidine / デクスメデトミジン / Pain mechanism / アフリカツメガエル卵母細胞系 / Anesthetics / イオンチャンネル / G蛋白共役型受容体 / イオンチャネル / 脊髄後根神経節 / Xenopus oocyte / Protein Kinase C (PKC) / ハロセン / 細胞内リン酸化酵素 / 静脈麻酔薬 / トラマドール / Electrophysiology / Analgesia / Receptor / Sadation / Anesthesia / 行動薬理学 / 痛み / 電気生理学 / 鎮痛 / 受容体 / 鎮静 / 麻酔 / Phosphorylation / Xenopus oocytes expression systems / Metabotropic glutamte receptors / Dorsal root ganglia cells / G protein couples receptors / メタボトロピックグルタミン酸受容体(cGluR) / 脊髄後根神経節(Dorsal Root Gnglia, DRG)細胞 / 脊髄後根神経節(DRG)細胞 / G蛋白結合受容体(GPCR) / メタボトロピックグルタミン酸受容体(mGluR) / 脊髄後根神経節(Dorsal Root Ganglia, DRG)細胞 / G蛋白共役型受容体(GPCR) / 疼痛メカニズム / Alohaxalone / Xenopus oocytes / Dorsal root ganglia / Volatile Anesthetics / G protein Coupled Receptor / Ion channel / pain / エタノール / パッチクランプ法 / 鎮痛薬 / 抗侵害作用 / サブスタンスP受容体 / 鎮痛作用機序 / アルファキサロン / 疼痛 / orexin A / Tramadol / substance P / G-protein coupled receptor (GPCR) / ion channels / dorsal root ganglia cells / G蛋白結合受容体 / 疼痛発生メカニズム / エーテル / ステロイド系静脈麻酔薬アルファキサロン / 電位依存性Naチャネル / オレキシンA / サブスタンスP / Halothane / Enflurane / Isoflurane / Protein G / Cannabinoid Receptor / Gq蛋白 / Gi / Ca^<2+>依存性Cl^-チャネル / G蛋白質共役型受容体 / Protein Kinase C(PKC) / G蛋白 / カナビノイド受容体 / ^3H-thymidine / 静脈性麻酔ケタミン / 動脈平滑筋 / 生活習慣病 / 動脈硬化 / 血管障害性動脈硬化 / [^3H]-thymidine / 細胞内cAMP / 静脈性麻酔薬ケタミン / 血管平滑筋増殖 / プロテインキナーゼC / 燐酸化酵素 / トラマドール代謝産物M1 / アフリカツメガエル卵母細胞 / 5HT_<2C>受容体 / 痙攣 / エンフルレン Less

The effects of dexmedetomidine on G protein coupled receptors
- Principal Investigator
  
  YOKOYAMA Toru
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
麻酔薬・鎮痛薬のナトリウムチャネルに対する作用機序及び作用部位の解析Principal Investigator
- Principal Investigator
  
  白石宗大
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
The study of the pain mechanisms using rat dorsal root ganglia
- Principal Investigator
  
  MINAMI Koucihiro
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Jichi Medical University
  University of Occupational and Environmental Health, Japan
The role of the metabotropic gultamete receptor in the pain mechanism
- Principal Investigator
  
  SHIGA Yousuke
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
麻酔薬、鎮痛薬の痙攣誘発作用におけるセロトニン受容体のはたす役割解明
- Principal Investigator
  
  相原啓二
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
麻酔薬の動脈硬化予防作用の臨床応用を目指した研究-麻酔薬の新たなる作用の検討-
- Principal Investigator
  
  SHIGEMATSU Akio
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan
The study of antinociceptive effects of anesthetics and analgesics using dorsal root ganglia cells.
- Principal Investigator
  
  SHIGEMATSU Akio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational Environmental Health(UOEH)
The effects of anesthetics and ethanol on cannabinoid receptor function.
- Principal Investigator
  
  KAMOCHI Masayuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  University of Occupational and Environmental Health, Japan

All 2007 2006 2005 2003 2002

All Journal Article Book

[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors. pp273-274)2005
- Author(s)
  Shiraishi M., et al.
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-17591657
[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors.(273-274)2005
- Author(s)
  Shiraishi M., et al.
- Total Pages
  342
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-16659429
[Book] Basic and Systemic Mechanisms of Anesthesia(A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors.pp273-274)2005
- Author(s)
  Shiraishi M., et al.
- Publisher
  ELSEVIER
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390479
[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors. Pp273-274)2005
- Author(s)
  Shiraishi M., et al.
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-17591656
[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors. Pp273-274)2005
- Author(s)
  Shiraishi M., et al.
- Total Pages
  342
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-16591574
[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors.2005
- Author(s)
  Shiraishi M., et al.
- Total Pages
  342
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-17791058
[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is eritical for anesthetic inhibition of NMDA receptors. pp273-274)2005
- Author(s)
  Shiraishi M., et al.
- Publisher
  ELSEVIER
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] Dcxmedetoniidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca^<2+> elevation in cultured rat dorsal root ganglia cells.2007
- Author(s)
  Takizuka A, Minami K, Uezono Y, Horishita T, Yokoyama T, Shiraishi M, Sakurai T, Shigematsu A, Ueta Y.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol 375(5)
  
  Pages: 293-301
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591735
[Journal Article] Effects of anesthetics on the function of orexiir 1 receptors expressed in Xen op us oocytes.2007
- Author(s)
  Minami K, Uezono Y, Sakurai T, Horishita T, Shiraishi M, Ueta Y.
- Journal Title
  
  Pharmacology. 79(4)
  
  Pages: 236-42
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591657
[Journal Article] Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca^<2+> elevation in clutured rat dorsal root ganglia cells2007
- Author(s)
  Takizuka A, Minami K, Uezono Y, Horishita T, Yokoyama T, Shiraishi M, Sakurai T, Shigenatsu A
- Journal Title
  
  Naunyn Schmeideberg's Arch Phramacology 375
  
  Pages: 293-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591735
[Journal Article] Effects of anesthetics on the function of orexin-l receptors expressed in Xenopus oocytes.2007
- Author(s)
  Minami K, Uezono Y, Sakurai T, Horishita T, Shiraishi M, Ueta Y.
- Journal Title
  
  Pharmacology 79(4)
  
  Pages: 236-242
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591735
[Journal Article] Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenop us oocytes and muscarine induced intracellular Ca^<2+> elevation in cultured rat dorsal root ganglia cells.2007
- Author(s)
  Takizuka A, Minami K, Uezono Y, Horishita T, Yokoyama T, Shiraishi M, Sakurai T, Shigematsu A, Ueta Y.
- Journal Title
  
  Naunyn Schmiedebergs Arch Pharmacol. 375(5)
  
  Pages: 293-301
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591657
[Journal Article] Dexmedetomidine inhibits muscarinic type 3 receptors expressed in Xenopus oocytes and muscarine-induced intracellular Ca^<2+> elevation in clutured rat dorsal root ganglia cells2007
- Author(s)
  Takizuka A, Minami K, Uezono Y, Horishita T, Yokoyama T, Shiraishi M, Sakurai T, Shigenatsu A.
- Journal Title
  
  Naunyn Schmeideberg's Arch Phramacology 375
  
  Pages: 293-301
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591735
[Journal Article] The tramadol mediate,O-desmetyl tramadol,inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes2006
- Author(s)
  Horishita T, Minami K, Uezono Y, Shiraishi M, Ogata J, Okamoto T, Shigematsu A.
- Journal Title
  
  Pharmacology 77
  
  Pages: 93-99
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591735
[Journal Article] The tramadol metabolite, O-desmethyl tramadol, inhibits 5-hydroxytryptamine type 2C receptors expressed in Xenopus Oocytes2006
- Author(s)
  Horishita T, Minami K, Uezono Y, Shiraishi M, Ogata J, Okamoto T, Shigematsu A.
- Journal Title
  
  Pharmacology 77(2)
  
  Pages: 93-99
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591735
[Journal Article] The inhibitory effects of alphaxalone on M_1 and M_3 muscarinic receptors expressed in Xenopus oocytes2003
- Author(s)
  Shiraishi M., et al.
- Journal Title
  
  Anesthesia & Analgesia 97・2
  
  Pages: 449-455
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14571479
[Journal Article] The inhibitory effects of alphaxalone on M1 and M3 muscarinic receptors expressed in Xenopus oocytes2003
- Author(s)
  Shiraishi M., et al.
- Journal Title
  
  Anesthesia & Analgesia 97・2
  
  Pages: 449-455
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] The inhibitory effects of alphaxalone on M_1 and M_3 muscarinic receptors expressed in Xenopus oocytes.2003
- Author(s)
  Shiraishi M., et al.
- Journal Title
  
  Anesth Analg 97・2
  
  Pages: 449-455
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571479
[Journal Article] The inhibitory effects of alphaxalone on M_1 and M_3 muscarinic receptors expressed in Xenopus oocytes.2003
- Author(s)
  Shiraishi M., et al.
- Journal Title
  
  Anesth Analg 97・2
  
  Pages: 449-455
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390479
[Journal Article] The inhibitory effects of alphaxalone on M1 and M3 muscarinic receptors expressed in Xenopus oocytes2003
- Author(s)
  Shiraishi M., et al.
- Journal Title
  
  Anesthesia & Analgesia 97・2
  
  Pages: 449-455
- Data Source
  KAKENHI-PROJECT-14571479
[Journal Article] Inhibitory effects of tramadol on nicotinic acetylcholine receptors in adrenal chromaffin cells and in Xenopus oocytes expressing α 7 receptors2002
- Author(s)
  Shiraishi M., et al.
- Journal Title
  
  Br J Pharmacol 136・2
  
  Pages: 207-216
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571479
[Journal Article] A neurosteroid anesthetic, alphaxalone, inhibits nicotinic acetylcholine reseptors in cultured bovine adrenal chromaffin cells2002
- Author(s)
  Shiraishi M., et al.
- Journal Title
  
  Anesth Analg 95
  
  Pages: 900-906
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14571479

1. MINAMI Kouitiro (70279347)

# of Collaborated Projects: 7 results

# of Collaborated Products: 8 results
2. UEZONO Yasuhito (20213340)

# of Collaborated Projects: 6 results

# of Collaborated Products: 2 results
3. HORISHITA Takahumi (40369070)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. SHIGEMATSU Akio (30037428)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. UETA Yoichi (10232745)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. 松井稔 (50282611)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 佐多竹良 (60128030)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KAMOCHI Masayuki (90204643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHIGA Yousuke (10399199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YOKOYAMA Toru (80425321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. ATUSHI Takizuka (00399205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 相原啓二 (70258622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 尾方純一 (50352331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIRAISHI Munehiro 白石 宗大

Research Projects

Research Products

Co-Researchers

The effects of dexmedetomidine on G protein coupled receptors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

麻酔薬・鎮痛薬のナトリウムチャネルに対する作用機序及び作用部位の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of the pain mechanisms using rat dorsal root ganglia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of the metabotropic gultamete receptor in the pain mechanism

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

麻酔薬、鎮痛薬の痙攣誘発作用におけるセロトニン受容体のはたす役割解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

麻酔薬の動脈硬化予防作用の臨床応用を目指した研究-麻酔薬の新たなる作用の検討-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of antinociceptive effects of anesthetics and analgesics using dorsal root ganglia cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effects of anesthetics and ethanol on cannabinoid receptor function.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors. pp273-274)2005

Author(s)

Publisher

Data Source

[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors.(273-274)2005

Author(s)

Total Pages

Publisher

Data Source

[Book] Basic and Systemic Mechanisms of Anesthesia(A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors.pp273-274)2005

Author(s)

Publisher

Description

Data Source

[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors. Pp273-274)2005

Author(s)

Publisher

Data Source

[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors. Pp273-274)2005

Author(s)

Total Pages

Publisher

Data Source

[Book] Basic and Systemic Mechanisms of Anesthesia (A residue in TM3 region of the NR1 subunit is critical for anesthetic inhibition of NMDA receptors.2005

Author(s)

Total Pages

Publisher

Data Source

SHIRAISHI Munehiro 白石宗大