MOTOSHIMA Hiroyuki 本島寛之

Researcher Number	40398201
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2021: 熊本大学, 大学院生命科学研究部(医), 特任准教授 2018: 熊本大学, 大学院生命科学研究部(医), 特任准教授(寄附講座) 2017: 熊本大学, 大学院生命科学研究部(医), 寄附講座教員 2016: 熊本大学, 大学院生命科学研究部糖尿病分子病態解析学寄附講座, 特任准教授 2010 – 2015: 熊本大学, 医学部附属病院, 助教 … More 2010: 熊本大学, 医学部附属病院, 特任助教 2009: 熊本大学, 医学部・付属病院, 医員 2008: 熊本大学, 医学部・附属病院, 医員 2008: 熊本大学, 医学部付属病院, 医員 2005 – 2008: 熊本大学, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Metabolomics / Basic Section 54040:Metabolism and endocrinology-related
Keywords	Principal Investigator インスリン抵抗性 / 肥満 / 炎症 / 脂肪細胞 / シグナル伝達 / 糖尿病 / リモデリング / 白色脂肪組織 / TNFα変換酵素 / ブラウニング … More / ２型糖尿病発症 / ADAM-8 / TNF１型受容体 / ２型糖尿病 / メタボリックシンドローム / サイトカイン / TNF-R1 / 蛋白質 / 細胞・組織 / 発現制御 / TNFa産生 / インスリンシグナル伝達 / ストレスキナーゼ / TNFa 変換酵素(TACE) … More Except Principal Investigator 糖尿病 / インスリン抵抗性 / MnSOD / 動脈硬化症 / Hsp72 / 動脈硬化 / PPARγ / CRTC2 / CREB / CRTC / Oxidative stress / Mitochondria / Diabetic complications / Diabetes Mellitus / PPARγアゴニスト / eNOS / 活性酸素 / ミトコンドリア / 糖尿病合併症 / 脂質代謝異常 / 膵β細胞 / 小胞体ストレス / インスリン分泌 / HSP72 / 糖尿病大血管合併症 / エネルギー・糖代謝異常 / 温熱電流同時印加療法 / 内臓脂肪 / 微弱電流 / 温熱 / cPLA2 / COX-2 / マクロファージ / 脂肪細胞 / cPLA_2 / メチルグリオキサール / 転写因子 Less

Examination of the role of CRTC, a CREB coactivator, on arteriosclerosis
- Principal Investigator
  
  Igata Motoyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kumamoto University
Inhibitory effect of TACE on WAT browningPrincipal Investigator
- Principal Investigator
  
  Motoshima Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Shedding of TNF receptors in adipose tissues and insulin resistancePrincipal Investigator
- Principal Investigator
  
  MOTOSHIMA HIROYUKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Downregulation of cPLA2 suppress atherosclerotic lesion formation in apolipoprotein-E deficient mice.
- Principal Investigator
  
  Matsumura Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
TNFa変換酵素を介したインスリン抵抗性発現機序の解析Principal Investigator
- Principal Investigator
  
  MOTOSHIMA Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Effect of cPLA_2 inhibition on the prevention of diabetic macrovascular complication
- Principal Investigator
  
  MATSUMURA Takeshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Identification of novel molecules associated with insulin action or insulin secretion induced by mild electric current and hyperthermia therapy
- Principal Investigator
  
  KONDO Tatsuya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Effect of cPLA_2 inhibition on improvement of glucose tolerance through PPARγ activation
- Principal Investigator
  
  MATSUMURA Takeshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
The molecular mechanisms of improvement of insulin resistance and reduction of visceral fat by combination of mild electrical current and thermo therapy
- Principal Investigator
  
  KONDO Tatsuya
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
Impact of mitochondria reactive oxygen species in the pathogenesis of diabetic macro- and micro vascular complications.
- Principal Investigator
  
  NISHIKAWA Takeshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University
高血糖によるメチルグリオキサール付加修飾蛋白の糖尿病血管合併症における意義
- Principal Investigator
  
  田口哲也
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Kumamoto University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] AMPキナーゼと動脈硬化.内分泌・糖尿病・代謝内科2011
- Author(s)
  本島寛之, 松村剛, 荒木栄一
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Impact of hepatic HSP72 on insulin signaling2019
- Author(s)
  Kitano Sayaka、Kondo Tatsuya、Matsuyama Rina、Ono Kaoru、Goto Rieko、Takaki Yuki、Hanatani Satoko、Sakaguchi Masaji、Igata Motoyuki、Kawashima Junji、Motoshima Hiroyuki、Matsumura Takeshi、Kai Hirofumi、Araki Eiichi
- Journal Title
  
  American Journal of Physiology-Endocrinology and Metabolism
  
  Volume: 316 Issue: 2 Pages: E305-E318
- DOI
  10.1152/ajpendo.00215.2018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09835, KAKENHI-PROJECT-18K16208, KAKENHI-PROJECT-16K09759, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-17H04201
[Journal Article] Identification of microRNA that represses IRS-1 expression in liver.2018
- Author(s)
  Ono K, Igata M, Kondo T, Kitano S, Takaki Y, Hanatani S, Sakaguchi M, Goto R, Senokuchi T, Kawashima J, Furukawa N, Motoshima H, Araki E
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 1 Pages: 0191553-0191553
- DOI
  10.1371/journal.pone.0191553
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09760, KAKENHI-PROJECT-15K09394, KAKENHI-PROJECT-15K15348, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-18K16208, KAKENHI-PROJECT-17H04201, KAKENHI-PROJECT-16K09759, KAKENHI-PROJECT-16K09787
[Journal Article] Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis.2018
- Author(s)
  Yamada S, Senokuchi T, Matsumura T, Morita Y, Ishii N, Fukuda K, Murakami S, Nishida S, Kawasaki S, Motoshima H, Furukawa N, Komohara Y, Fujiwara Y, Koga T, Yamagata K, Takeya M, Araki E
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 印刷中 Issue: 5 Pages: 994-1006
- DOI
  10.1161/atvbaha.117.310320
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09835, KAKENHI-PROJECT-17K09863, KAKENHI-PROJECT-15K09394, KAKENHI-PROJECT-15K15348, KAKENHI-PROJECT-17K08664, KAKENHI-PROJECT-18K08482, KAKENHI-PROJECT-16H05328, KAKENHI-PROJECT-17H04060, KAKENHI-PROJECT-17H04201, KAKENHI-PROJECT-16K09247, KAKENHI-PROJECT-16K09759, KAKENHI-PROJECT-16K09787, KAKENHI-PROJECT-17K16151
[Journal Article] Low glucose induces mitochondrial reactive oxygen species via fatty acid oxidation in bovine aortic endothelial cells.2017
- Author(s)
  Kajihara N, Kukidome D, Sada K, Motoshima H, Furukawa N, Matsumura T, Nishikawa T, Araki E.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 印刷中 Issue: 6 Pages: 750-761
- DOI
  10.1111/jdi.12678
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09393, KAKENHI-PROJECT-16K09759, KAKENHI-PROJECT-15K15348, KAKENHI-PROJECT-16K09787, KAKENHI-PROJECT-17K09835, KAKENHI-PROJECT-15K09394
[Journal Article] Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial.2016
- Author(s)
  Kondo T, Goto R, Ono K, Kitano S, Suico MA, Sato M, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E.
- Journal Title
  
  Sci Rep.
  
  Volume: 19 Issue: 1 Pages: 35690-35690
- DOI
  10.1038/srep35690
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460098, KAKENHI-PROJECT-15K12514, KAKENHI-PROJECT-15K09394, KAKENHI-PROJECT-16K09759
[Journal Article] Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice2016
- Author(s)
  Hanatani S, Motoshima H, Takaki Y, Kawasaki S, Igata M, Matsumura T, Kondo T, Senokuchi T, Ishii N, Kawashima J, Kukidome D, Shimoda S, Nishikawa T, Araki E
- Journal Title
  
  J Clin Biochem Nutr
  
  Volume: 59 Pages: 207-214
- NAID
  130005268723
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K09759
[Journal Article] Hyperglycemia Induces Cellular Hypoxia through Production of Mitochondrial ROS Followed by Suppression of Aquaporin-1.2016
- Author(s)
  Sada K, Nishikawa T, Kukidome D, Yoshinaga T, Kajihara N, Sonoda K, Senokuchi1 T, Motoshima H, Matsumura T, Araki E
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 7 Pages: e0158619-e0158619
- DOI
  10.1371/journal.pone.0158619
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461340, KAKENHI-PROJECT-16K09759, KAKENHI-PROJECT-15K15348
[Journal Article] Coexistence of resistance to thyroid hormone and papillary thyroid carcinoma2016
- Author(s)
  Igata M, Tsuruzoe K, Kawashima J, Kukidome D, Kondo T, Motoshima H, Shimoda S, Furukawa N, Nishikawa T, Miyamura N, Araki E
- Journal Title
  
  Endocrinology, Diabetes & Metabolism
  
  Volume: 2016 Pages: 160003-160003
- DOI
  10.1530/edm-16-0003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09759
[Journal Article] Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-gamma activation.2015
- Author(s)
  Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 457 Pages: 23-30
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461374
[Journal Article] Insulin requirement profiles in Japanese hospitalized subjects with type 2 diabetes treated with basal-bolus insulin therapy2015
- Author(s)
  Shimoda S, Okubo M, Koga K, Sekigami T, Kawashima J, Kukidome D, Igata M, Ishii N, Shimakawa A, Matsumura T, Motoshima H, Furukawa N, Nishida K, Araki E
- Journal Title
  
  Endocr J
  
  Volume: 62 Issue: 2 Pages: 209-216
- DOI
  10.1507/endocrj.EJ14-0487
- NAID
  130004704365
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461360, KAKENHI-PROJECT-25461374
[Journal Article] Statins meditate anti-atherosclerotic action in smooth muscle cells by peroxisome proliferator-activated receptor-γ activation.2014
- Author(s)
  Fukuda K, Matsumura T, Senokuchi T, Ishii N, Kinoshita H, Yamada S, Murakami S, Nakao S, Motoshima H, Kondo T, Kukidome D, Kawasaki S, Kawada T, Nishikawa T, Araki E
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 457 Issue: 1 Pages: 23-20
- DOI
  10.1016/j.bbrc.2014.12.063
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591336, KAKENHI-PROJECT-25461361, KAKENHI-PROJECT-26461340, KAKENHI-PROJECT-25461360, KAKENHI-PROJECT-25461374
[Journal Article] Comparison of the efficacy of sitagliptin and glimepiride dose-up in Japanese patients with type 2 diabetes poorly controlled by sitagliptin and glimepiride in combination.2014
- Author(s)
  Shimoda S, Iwashita S, Sekigami T, Furukawa N, Matsuo Y, Ichimori S, Goto R, Maeda T, Watanabe E, Kondo T, Matsumura T, Motoshima H, Nishida K, Araki E
- Journal Title
  
  J Diabetes Investig
  
  Volume: 5 Issue: 3 Pages: 320-326
- DOI
  10.1111/jdi.12151
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461360, KAKENHI-PROJECT-25461374
[Journal Article] Mild electrical stimulation with heat shock reduces visceral adiposity and improves metabolic abnormalities in subjects with metabolic syndrome or type 2 diabetes: Randomized crossover trials.2014
- Author(s)
  Kondo T, Ono K, Kitano S, Matsuyama R, Goto R, Suico MA, Kawasaki S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E
- Journal Title
  
  EBioMedicine
  
  Volume: 1 Issue: 1 Pages: 80-89
- DOI
  10.1016/j.ebiom.2014.11.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591336, KAKENHI-PROJECT-25461360, KAKENHI-PROJECT-25461374, KAKENHI-PROJECT-25670260, KAKENHI-PROJECT-26460098
[Journal Article] The role of heat shock response in insulin resistance and diabetes.2014
- Author(s)
  Kondo T, Motoshima H, Igata M, Kawashima J, Matsumura T, Kai H, Araki E
- Journal Title
  
  Diabetes Metab J
  
  Volume: 38 Issue: 2 Pages: 100-1006
- DOI
  10.4093/dmj.2014.38.2.100
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24591336, KAKENHI-PROJECT-25461360, KAKENHI-PROJECT-25461374, KAKENHI-PROJECT-25670260, KAKENHI-PROJECT-26460098
[Journal Article] Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages2013
- Author(s)
  木下博之
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 431 Issue: 2 Pages: 124-130
- DOI
  10.1016/j.bbrc.2013.01.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590987, KAKENHI-PROJECT-23390243, KAKENHI-PROJECT-23591312, KAKENHI-PROJECT-23591337, KAKENHI-PROJECT-23791038, KAKENHI-PROJECT-24591336, KAKENHI-PROJECT-25461374
[Journal Article] Regulation of TNFα converting enzyme activity in visceral adipose tissue of obese mice2013
- Author(s)
  川崎修二
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 430 Issue: 4 Pages: 1189-1194
- DOI
  10.1016/j.bbrc.2012.12.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590987, KAKENHI-PROJECT-23390243, KAKENHI-PROJECT-23591312, KAKENHI-PROJECT-23791038, KAKENHI-PROJECT-24591336, KAKENHI-PROJECT-25461374
[Journal Article] Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.2013
- Author(s)
  Miyagawa K, Kondo T, Goto R, Matsuyama R, Ono K, Kitano S, Kawasaki S, Igata M, Kawashima J, Matsumura T, Motoshima H, Araki E.
- Journal Title
  
  Cardiovascular Diabetology
  
  Volume: 12(1) Issue: 1 Pages: 160-160
- DOI
  10.1186/1475-2840-12-160
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390243, KAKENHI-PROJECT-23591337, KAKENHI-PROJECT-24591336, KAKENHI-PROJECT-25461374
[Journal Article] Regulation of TNFαconverting enzyme activity invisceral adipose tissue of obese mice2013
- Author(s)
  Kawasaki S, Motoshima H, Hanatani S,Takaki Y, Igata M, Tsutsumi A,Matsumura T, Kondo T, Senokuchi T,Ishii N, Kinoshita H, Fukuda K,Kawashima J, Shimoda S, NishikawaT, Araki E
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 430 Pages: 1189-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590987
[Journal Article] Apocynin suppresses theprogression of atherosclerosis inapoE-deficient mice by inactivationof macrophages2013
- Author(s)
  Kinoshita H, Matsumura T, Ishii N,Fukuda K, Senokuchi T, Motoshima H,Kondo T, Taketa K, Kawasaki S,Hanatani S, Takeya M, Nishikawa T,Araki E
- Journal Title
  
  Biochem Biophys ResCommun
  
  Volume: 431 Pages: 124-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590987
[Journal Article] Efficacy and safety of sitagliptin as add-on therapy on glycemic control and blood glucose fluctuation in Japanese type 2 diabetes subjects ongoing with multiple daily insulin injections therapy2013
- Author(s)
  Shimoda S, Iwashita S, Ichimori S, Matsuo Y, Goto R, Maeda T, Matsuo T, Sekigami T, Kawashima J, Kondo T, Matsumura T, Motoshima H, Furukawa N, Nishida K, Araki E.
- Journal Title
  
  Endocr J
  
  Volume: 60 Issue: 10 Pages: 1207-1214
- DOI
  10.1507/endocrj.EJ13-0198
- NAID
  130004770390
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390243, KAKENHI-PROJECT-24591336, KAKENHI-PROJECT-25461374
[Journal Article] Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes.2013
- Author(s)
  Matsumura T, Taketa K, Motoshima H, Senokuchi T, Ishii N, Kinoshita H, Fukuda K, Yamada S, Kukidome D, Kondo T, Hisada A, Katoh T, Shimoda S, Nishikawa T, Araki E.
- Journal Title
  
  Cardiovascular Diabetology
  
  Volume: 12(1) Issue: 1 Pages: 177-177
- DOI
  10.1186/1475-2840-12-177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390243, KAKENHI-PROJECT-23591312, KAKENHI-PROJECT-24591336, KAKENHI-PROJECT-25461374
[Journal Article] Hyperthermia With Mild Electrical Stimulation Protects Pancreatic β-Cells From Cell Stresses and Apoptosis2012
- Author(s)
  Kondo T, Sasaki K, Matsuyama R, Morino-Koga S, Adachi H, Suico MA, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
- Journal Title
  
  Diabetes
  
  Volume: 61(4) Issue: 4 Pages: 838-847
- DOI
  10.2337/db11-1098
- NAID
  120005368280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145, KAKENHI-PROJECT-23390243, KAKENHI-PROJECT-23650269, KAKENHI-PROJECT-24591336
[Journal Article] Hyperthermia with Mild Electrical Stimultation Protects Pancreatic b-Cells From Cell Stresses and Apoptosis2012
- Author(s)
  Kondo T, Sasaki K, Matsuyama R, Morino-Koga S, Adachi H, Suico MA, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
- Journal Title
  
  Diabetes
  
  Volume: 61(4) Pages: 838-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] Hyperthermia With MildElectrical Stimulation ProtectsPancreatic ss-Cells From Cell Stressesand Apoptosis2012
- Author(s)
  Kondo T, Sasaki K, Matsuyama R,Morino-Koga S, Adachi H, Suico MA,Kawashima J, Motoshima H, Furukawa N,Kai H, Araki E
- Journal Title
  
  Diabetes
  
  Volume: 61 Pages: 837-847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590987
[Journal Article] Hyperthermia With Mild Electrical Stimulation Protects Pancreaticβ-Cells From Cell Stresses and Apoptosis2012
- Author(s)
  Kondo T, Sasaki K, Matsuyama R, Morino-Koga S, Adachi H, Suico MA, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
- Journal Title
  
  Diabetes
  
  Volume: 61 Pages: 837-847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Caloric restriction decreases ER stress in liver and adipose tissue in ob/ob mice2011
- Author(s)
  Tsutsumi A, Motoshima H, Kondo T, Kawasaki S, Matsumura T, Hanatani S, Igata M, Ishii N, Kinoshita H, Kawashima J, Taketa K, Furukawa N, Tsuruzoe K, Nishikawa T, Araki E
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 404 Pages: 339-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Caloricrestriction decreases ER stress inliver and adipose tissue in ob/ob mice2011
- Author(s)
  Tsutsumi A, Motoshima H, Kondo T,Kawasaki S, Matsumura T, Hanatani S,Igata M, Ishii N, Kinoshita H, KawashimaJ, Taketa K, Furukawa N, Tsuruzoe K,Nishikawa T, Araki E
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 404 Pages: 339-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590987
[Journal Article] Telmisartan exerts antiatheroscleroticeffects by activating peroxisomeproliferator-activated receptor-r inmacrophages2011
- Author(s)
  Matsumura T, Kinoshita H, Ishii N,Fukuda K, Motoshima H, Senokuchi T,Take ta K, Ka was aki S, N ish im aki- Mog ami T,Kawada T, Nishikawa T, Araki E
- Journal Title
  
  Arterioscler Thromb VascBiol
  
  Volume: 31 Pages: 1268-1275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590987
[Journal Article] Telmisartan exerts anti-atherosclerotic effects by activating PPARγin macrophages2011
- Author(s)
  Matsumura T, Kinoshita H, Ishii N, Fukuda K, Motoshima H, Senokuchi T, Taketa K, Kawasaki S, Nishimaki-Mogami T, Kawada T, Nishikawa T, Araki E
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 31 Pages: 1268-1275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] A case of ectopic adrenocorticotropic hormoneproducing pancreatic neuroendocrine tumor with multiple liver metastases2010
- Author(s)
  Kondo, T., Matsuyama, R., Ashihara, H., Matsuo, Y., Sasaki, K., Goto, R., Ono, K., T akaki, Y., Honda, Y., Iyama, K., Kawashima, J., Motoshima, H., Tsuruzoe, K., Miyamura, N. and Araki, E
- Journal Title
  
  Endocrine J
  
  Volume: 57(3) Pages: 229-236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010
- Author(s)
  Hironori Adachi, Tatsuya Kondo, K. Tsuruzoe, H Motoshima, E Araki, et al
- Journal Title
  
  American Journal of Physiology.Endocrinology and Metabolism.
  
  Volume: 29(5) Pages: 764-771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010
- Author(s)
  Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 299
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] The effect of group-based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome : the Tabaruzaka Study 12010
- Author(s)
  Yamashiro T, Nishikawa T, Isami S, Wei CN, Fukumoto K, Matsuo H, Yoshinaga T, Kukidome D, Motoshima H, Matsumura T, Ueda A, Araki E
- Journal Title
  
  Diabetes Obes Metab
  
  Volume: 12 Pages: 790-797
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Heat Shock Treatment with Mild Electrical Stimulation Safely Reduced Inflammatory Markers in Healthy Male Subjects2010
- Author(s)
  Kondo, T., Sasaki, K., Adachi, H., Nakayama, Y., Hatemura, M., Matsuyama, R., Tsuruzoe, K., Furukawa, N., Motoshima, H., Morino, S., Yamashita, Y., Miyamura, N., Kai, H., Araki, E.
- Journal Title
  
  Obesity Research and Clinical Practice (In press)
- NAID
  120003184552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] An Acylic Polyisoprenoid Derivative, Geranylgeranylacetone Protects Against Visceral Adiposity and Insulin Resistance in High Fat Fed Mice2010
- Author(s)
  Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 29(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] Nifedipine induces peroxisome proliferator-activated receptor-gamma activation in macrophages and suppresses the progression of atherosclerosis in apolipoprotein E-deficient mice2010
- Author(s)
  Ishii N, Matsumura T, Kinoshita H, Fukuda K, Motoshima H, Senokuchi T, Nakao S, Tsutsumi A, Kim-Mitsuyama S, Kawada T, Takeya M, Miyamura N, Nishikawa T, Araki E
- Journal Title
  
  Arterioscler Thromb Vasc Biol
  
  Volume: 30 Pages: 1598-1605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Heat Shock Treatment with Mild Electrical Stimulation Safely Reduced Inflammatory Markers in Healthy Male Subjects2010
- Author(s)
  Kondo, T., Sasaki, K., Adachi, H., Nakayama, Y., Hatemura, M., Matsuyama, R., Ts uruzoe, K., Furukawa, N., Motoshima, H., Mori no, S., Yamashita, Y., Miyamura, N., Kai, H. and Araki, E
- Journal Title
  
  Obesity Res. Clin. Pract
  
  Volume: 4(2)
- NAID
  120003184552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591145
[Journal Article] TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis2009
- Author(s)
  Fujisawa K, Nishikawa T, Kukidome D, Imoto K, Yamashiro T, Motoshima H, Matsumura T, Araki E
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 379 Pages: 43-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis2009
- Author(s)
  Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 379 Pages: 806-811
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Activation of AMP-activated protein kinase suppresses oxidized low-density lipoprotein-induced macrophage proliferation2009
- Author(s)
  Ishii N, Matsumura T, Kinoshita H, Motoshima H, Kojima K, Tsutsumi A, Kawasaki S, Yano M, Senokuchi T, Asano T, Nishikawa T, Araki E
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 34561-34569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591144
[Journal Article] Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis2009
- Author(s)
  Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa. N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E
- Journal Title
  
  Biochem Biophys Res Commun 379(4)
  
  Pages: 806-11
- Data Source
  KAKENHI-PROJECT-19591058
[Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008
- Author(s)
  Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E.
- Journal Title
  
  Biochem Biophys Res Commun 376(2)
  
  Pages: 434-8
- Data Source
  KAKENHI-PROJECT-19591058
[Journal Article] Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues2008
- Author(s)
  Kojima K, Motoshima H, Tsutsumi A, Igata M, Matsumura T, Kondo T, Kawashima J, Ichinose K, Furukawa N, Inukai K, Katayama S, Goldstein BJ, Nishikawa T, Tsuruzoe K, Araki E
- Journal Title
  
  Biochem Biophys Res Commun 376
  
  Pages: 434-438
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591056
[Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice2008
- Author(s)
  Goto, H., Nishikawa, T.*, Sonoda, K., Kondo, T., Kukidome, D., Fujisawa, K., Yamashiro, T., Motoshima, H., Matsumura, T., Tsuruzoe, K., Araki, E.
- Journal Title
  
  Biochem Biophys Res Commun 366
  
  Pages: 814-820
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590995
[Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice2008
- Author(s)
  Goto H, Nishikawa T, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E
- Journal Title
  
  Biochem Biophys Res Commun 366(3)
  
  Pages: 814-20
- Data Source
  KAKENHI-PROJECT-19591058
[Journal Article] Endothelial MnSOD overexpression prevents retinal VEGF expression in diabetic mice2008
- Author(s)
  Goto H, Nishikawa T, Sonoda K, Kondo T, Kukidome D, Fujisawa K, Yamashiro T, Motoshima H, Matsumura T, Tsuruzoe K, Araki E
- Journal Title
  
  Biochem Biophys Res Commun 366
  
  Pages: 814-820
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591056
[Journal Article] Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-a(PPARa) and PPARy through MAPK-dependent COX-2 expression in macrophages.2008
- Author(s)
  Taketa, K., Matsumura, T., Yano, M., Ishii, N., Senokuchi, T., Motoshima, H., Murata, Y., Kim-Mitsuyama, S., Kawada, T., Itabe, H., Takeya, M., Nishikawa, T., Tsuruzoe, K., Araki, E.
- Journal Title
  
  J Biol Chem 283
  
  Pages: 9852-9862
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590995
[Journal Article] Ox-LDL activates PPARα and PPARγ through MAPK-dependent COX-2 expression in macrophages2008
- Author(s)
  Taketa K, Matsumura T, Yano M, Ishii N, Senokuchi T, Motoshima H, Murata Y, Kim-Mitsuyama S, Kawada T, Itabe H, Takeya M, Nishikawa T, Tsuruzoe K, Araki E
- Journal Title
  
  J Biol Chem 283
  
  Pages: 9852-9862
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591056
[Journal Article] Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation : impact of the suppression of nuclear translocation of ERK1/22007
- Author(s)
  Yano, M., Matsumura, T., Senokuchi, T., Ishii, N., Motoshima, H., Taguchi, T., Matsuo, T., Sonoda, K., Kukidome, D., Sakai, M., Kawada, T., Nishikawa, N., Araki, E.
- Journal Title
  
  Atherosclerosis 191
  
  Pages: 22-32
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590995
[Journal Article] Impact of mitochondrial ROS production on diabetic vascular complications2007
- Author(s)
  Nishikawa T, Kukidome D, Sonoda K, Fujisawa K, Matsuhisa T, Motoshima H, Matsumura T, Araki E
- Journal Title
  
  Diabetes Res Clin Pract 77Suppl1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591056
[Journal Article] Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages.2007
- Author(s)
  Yano, M., Matsumura, T., Senokuchi, T., Ishii, N., Murata, Y., Taketa, K., Motoshima, H., Taguchi, T., Sonoda, K., Kukidome, D., Takuwa, Y., Kawada, T., Brownlee, M., Nishikawa, T., Araki, E.
- Journal Title
  
  Circ Res 100
  
  Pages: 1442-1451
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590995
[Journal Article] Impact of mitochondrial ROS production in the pathogenesis of insulin resistance2007
- Author(s)
  Nishikawa T, Kukidome D, Sonoda K, Fujisawa K, Matsuhisa T, Motoshima H, Matsumura T, Araki E
- Journal Title
  
  Diabetes Res Clin Pract 77Suppl1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591056
[Journal Article] Impact of mitochondrial ROS production on diabetic vascular complications.(* corresponding author)2007
- Author(s)
  Nishikawa, T.*, Kukidome, D., Sonoda, K., Fujisawa, K., Matsuhisa, T., Motoshima, H., Matsumura, T., Araki, E.
- Journal Title
  
  Diabetes Res Clin Prat 77S
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590995
[Journal Article] Troglitazone inhibits oxidized low-density lipoprotein-induced macrophage proliferation : impact of the suppression of nuclear translocation of ERK1/22007
- Author(s)
  Yano M, Matsumura T, Senokuchi T, Ishii N, Motoshima H, Taguchi T, Matsuo T, Sonoda K, Kukidome D, Sakai M, Kawada T, Nishikawa N, Araki E
- Journal Title
  
  Atherosclerosis 191
  
  Pages: 22-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591056
[Journal Article] IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance2007
- Author(s)
  Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E
- Journal Title
  
  Biochem Biophys Res Commun 364(2)
  
  Pages: 301-7
- Data Source
  KAKENHI-PROJECT-19591058
[Journal Article] Impact of mitochondrial ROS production in the pathogenesis of insulin resistance.(* corresponding author)2007
- Author(s)
  Nishikawa, T.*, Kukidome, D., Sonoda, K., Fujisawa, K., Matsuhisa, T., Motoshima, H., Matsumura, T., Araki, E.
- Journal Title
  
  Diabetes Res Clin Pract77S
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590995
[Journal Article] Statins activate peroxisome proliferator-activated receptor-γ through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages2007
- Author(s)
  Yano M, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, Motoshima H, Taguchi T, Sonoda K, Kukidome D, Takuwa Y, Kawada T, Brownlee M, Nishikawa T, Araki E
- Journal Title
  
  Circ Res 100
  
  Pages: 1442-1451
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591056
[Presentation] Impacts of the Kumamoto Earthquake 2016 on glycemic control in diabetic patients.2018
- Author(s)
  Kondo T, Miyakawa N, Motoshima H, Ishii N, Igata M, Yoshinaga K, Kukidome D, Senokuchi T, Kawashima J, Matsumura T, Araki E
- Organizer
  The 78th ADA Scientific Meetng
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] 災害時の糖尿病診療 -災害時に糖尿病患者を守るために-2018
- Author(s)
  本島寛之
- Organizer
  第52回糖尿病学の進歩
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] Empagliflozin suppresses atherosclerotic lesion formation in apolipoprotein E deficient mice by inhibiting macrophage activation.2018
- Author(s)
  Matsumura T, Murakami-Nishida S, Senokuchi T, Ishii N, Nishida S, Kondo T, Motoshima H, Araki E
- Organizer
  54th EASD Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] 糖尿病腎症４期の患者へのGLP-1受容体作動薬(GLP-1RA)使用の効果と注意点.2018
- Author(s)
  本島寛之, 井形元維, 近藤龍也, 久木留大介, 花谷聡子, 吉永佳代, 瀬ノ口隆文, 河島淳司, 松村剛, 荒木栄一
- Organizer
  第56回日本糖尿病学会九州地方会
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] 熊本地震の糖尿病関連入院への影響　―入院レセプトデータからの入院理由・数の推定と被災患者支援のあり方―.2017
- Author(s)
  本島寛之, 石井規夫, 西田健朗, 河島淳司, 久保田恭鼓, 久木留大介, 井形元維, 佐田公範, 花谷聡子, 高木優樹, 可徳美里, 三島裕子, 瀬ノ口隆文, 近藤龍也, 松村剛, 荒木栄一
- Organizer
  第60回日本糖尿病学会年次学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] Obesity-induced microRNA-222 impairs insulin signaling through the repression of IRS-1 expression in hepatocytes.2017
- Author(s)
  Ono K, Igata M, Kondo T, Kitano S, Takaki Yuki, Hanatani S, Goto R, enokuchi T, Kawashima J, Furukawa N, Motoshima H, ArakiE
- Organizer
  The 53th EASD Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] Roles of Heat Shock Protein 72 in Mice Model of Type 2 Diabetes.2017
- Author(s)
  Kondo T, Kitano S, Goto R, Ono K, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, ArakiE
- Organizer
  The 77th ADA scientific meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] The therapeutic potential of heat shock protein 72 in mice model of type 2 diabetes.2017
- Author(s)
  Kondo T, Kitano S, MIyakawa N, Goto R, Ono K, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, ArakiE
- Organizer
  IDF congress 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] Activation of Heat Shock Response Provided by Mild Electrical Stimulation with Heat Shock Improves Metabolic Abnormalities in Obese Subjects with Type 2 Diabetes2016
- Author(s)
  Kondo T, Goto R, Ono K, Kitano S, Igata M, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E
- Organizer
  52th EASD Annual Meeting
- Place of Presentation
  Messe Munchen, Munich, Germany
- Year and Date
  2016-09-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] Aldosterone excess state causes a chronic inflammation in pancreatic islet and eplerenone protects islet via GLP-1 secretion2016
- Author(s)
  Goto R, Kondo T, Kitano S, Ono K, Kawashima J, Matsumura T, Motoshima H, Araki E
- Organizer
  ISH 2016 satellite symposium, Renin-angiotensin-aldosterone system (RAAS)
- Place of Presentation
  Congress Square Nihonbashi, Tokyo, Japan
- Year and Date
  2016-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] 酢酸の経口摂取による抗肥満作用の検討2016
- Author(s)
  花谷聡子, 本島寛之, 井形元維, 川崎修二, 高木優樹, 河島淳司, 近藤龍也, 吉永佳代, 瀬ノ口隆文, 荒木栄一
- Organizer
  第54回日本糖尿病学会九州地方会
- Place of Presentation
  かごしま県民交流センター、鹿児島市
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] 正常およびGTG誘発性肥満マウスの肝における既知の細胞老化マーカーの検討2016
- Author(s)
  本島寛之, 高木優樹, 花谷聡子, 川崎修二, 井形元維, 吉永佳代, 河島淳司, 瀬ノ口隆文, 近藤龍也, 松村剛, 古川昇, 荒木栄一
- Organizer
  第3回肝臓と糖尿病・代謝研究会
- Place of Presentation
  石川県立音楽堂、野々市
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] 熊本の糖尿病・生活習慣病予防の取組，「ブルーサークルメニュー（BCM）開発」の新たな展開～BCM社員食堂版の効果～2016
- Author(s)
  本島寛之, 毛井順子, 宮田真理子, 三浦幸輔, 前中あおい, 三島裕子, 久木留大介, 川島隆文, 後藤理英子, 吉村沢子, 長瀬博美, 福田伴美, 白坂亜子, 関上泰二, 下田誠也, 岸川秀樹, 村岡まき子, 下村弘之, 猪原淑子, 柿村葉子, 荒木栄一
- Organizer
  第59回日本糖尿病学会年次学術集会
- Place of Presentation
  京都国際会議場、京都市
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K09759
[Presentation] 肥満2型糖尿病におけるHDL亜分画とインスリン抵抗性との関連性の検討2015
- Author(s)
  松村剛, 瀬ノ口隆文, 石井規夫, 木下博之, 福田一起, 山田沙梨恵, 村上彩子, 本島寛之, 近藤龍也, 西川武志, 荒木栄一
- Organizer
  第65回日本体質医学会
- Place of Presentation
  札幌
- Year and Date
  2015-07-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] Aldosterone excess state causes a chronic inflammation in the pancreatic islet.2015
- Author(s)
  Goto R, Kondo T, Kitano S, Ono K, Matsuyama R, Igata M, Kawashima J, Matsumura T, Motoshima H, Shimoda S, Araki E
- Organizer
  The 75th ADA scientific meeting
- Place of Presentation
  World Trade Center, Boston, MA, USA
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] 従業員の健康増進に、ブルーサークルメニューは有効か？-化血研社員食堂における取組-2015
- Author(s)
  毛井順子, 本島寛之, 宮田真理子, 川島隆文, 三島裕子, 前中あおい, 長瀬博美, 吉村沢子, 三浦幸輔, 下村弘之, 猪原淑子, 柿村葉子, 下田誠也, 荒木栄一
- Organizer
  第53回日本糖尿病学会九州地方会
- Place of Presentation
  福岡
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-25461360
[Presentation] 高血糖は細胞内低酸素とミトコンドリア由来活性酸素種(mtROS)産生を誘導し、両者の相互作用が糖尿病合併症を進展する.2015
- Author(s)
  佐田公紀, 西川武志, 久木留大介, 梶原伸宏, 本島寛之, 松村剛, 荒木栄一
- Organizer
  第27回分子糖尿病学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-12-05
- Data Source
  KAKENHI-PROJECT-25461360
[Presentation] 熊本における食環境整備ブルーサークルメニュー開発の新たな展開―社員食堂版の開発―2015
- Author(s)
  本島寛之, 柿村葉子, 三浦幸輔, 毛井順子, 村岡まき子, 久木留大介, 三島裕子, 前中あおい, 長瀬博美, 宮田真理子, 川島隆文, 後藤理英子, 吉村沢子, 福田伴美, 猪原淑子, 関上泰二, 白坂亜子, 岸川秀樹, 下田誠也, 荒木栄一
- Organizer
  第53回日本糖尿病学会九州地方会
- Place of Presentation
  福岡
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-25461360
[Presentation] Cellular hypoxia and mitochondrial reactive oxygen species may promote hyperglycaemic damage in a coordinated manner.2015
- Author(s)
  Sata K, Nishikawa T, Kukidome D, Kajiwara N, Motoshima H, Matsumura T, Araki E
- Organizer
  51th EASD Annual Meeting
- Place of Presentation
  Stockholm, Sweden
- Year and Date
  2015-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] インスリン抵抗性および動脈硬化症発症・進展におけるマクロファージ増殖の意義の検討.2015
- Author(s)
  瀬ノ口隆文, 山田沙梨恵, 松村剛, 本島寛之, 石井規夫, 福田一起, 村上彩子, 守田雄太郎, 西川武志, 荒木栄一
- Organizer
  第53回日本糖尿病学会九州地方会
- Place of Presentation
  福岡
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-25461360
[Presentation] 単鎖脂肪酸の経口摂取はAMPキナーゼ非依存性に内臓脂肪の褐色化（Browning）を誘導する.2015
- Author(s)
  花谷聡子, 本島寛之, 井形元維, 川崎修二, 高木優樹, 河島淳司, 近藤龍也, 岸川秀樹, 荒木栄一
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  下関
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25461360
[Presentation] 2型糖尿病におけるHDL亜分画とインスリン抵抗性との関連2015
- Author(s)
  松村剛, 木下博之, 本島寛之, 近藤龍也, 瀬ノ口隆文, 石井規夫, 松嶋和美, 杉内博幸, 西川武志, 荒木栄一
- Organizer
  第112回日本内科学会
- Place of Presentation
  京都
- Year and Date
  2015-04-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] Impacts of Heat Shock Protein 72 in Hepatic Glucose Metabolism in Model Mice of Type 2 Diabetes.2015
- Author(s)
  Kondo T, Matsuyama R, Kitano S, Goto R, Ono K, Kawashima J, Motoshima H, Matsumura T, Kai H, Araki E
- Organizer
  The 75th ADA scientific meeting
- Place of Presentation
  World Trade Center, Boston, MA, USA
- Year and Date
  2015-06-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] インスリン抵抗性、動脈硬化の発症・進展における組織浸潤マクロファージ増殖の生理学的意義の検討2014
- Author(s)
  瀬ノ口隆文, 山田沙梨恵, 松村剛, 本島寛之, 西川武志, 荒木栄一
- Organizer
  第26回分子糖尿病学シンポジウム
- Place of Presentation
  高知
- Year and Date
  2014-12-06
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] TNF-α Up-regulates TNF-α Converting Enzyme (TACE) in Visceral Adipose Tissues via JNK and PKC Activation2012
- Author(s)
  本島寛之
- Organizer
  The 48th Annual Meeting of the Europian Association for the Study of Diatebes
- Place of Presentation
  ドイツ・ベルリン　ベルリンコンベンションセンター
- Data Source
  KAKENHI-PROJECT-22590987
[Presentation] DPP-4阻害薬シタグリプチンの血糖コントロールおよび血圧への影響の解析-１年間投与症例における後ろ向き調査-2012
- Author(s)
  本島寛之
- Organizer
  第55回日本糖尿病学会年次学術集会
- Place of Presentation
  横浜市パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22590987
[Presentation] Activation of Heat Shock Response Improves Metabolic Profiles in Male Subjects with Metabolic Syndrome and Type2Diabetes2011
- Author(s)
  Kondo T, Matsuyama R, Miyagawa K, Goto R, Kawashima J, Motoshima H, Furukawa N, Kai H, Araki E
- Organizer
  16th Japan-Korea Symposium on Diabetes Mellitus
- Place of Presentation
  Tokyo, Hilton Tokyo Bay Hotel, Japan
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] Activation of Heat Shock Response Reduces Visceral Adiposity, Improves Insulin Resistance and Inflammatory Markers in Male Subjects with Metabolic Syndrome and Type 2 Diabetes2011
- Author(s)
  Tatsuya Kondo, Rina Matsuyama, Saori Koga, Katsutoshi Miyagawa, Rieko Goto, Mary Ann Suico, Junji Kawashima, Hiroyuki Motoshima, Noboru Furukawa, Kaku Tsuruzoe, Hirofumi Kai, Eiichi Araki
- Organizer
  ENDO 2011 (American Endocrine Society Meeting)
- Place of Presentation
  Boston, USA
- Year and Date
  2011-06-04
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 血糖指標としての血中可溶性インスリン受容体-ステロイドによる糖代謝悪化を検出できるのか?-2011
- Author(s)
  本島寛之
- Organizer
  第54回日本糖尿病学会年次学術集会
- Place of Presentation
  札幌プリンスホテル国際館パミール(北海道)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22590987
[Presentation] 血糖指標としての血中可溶性インスリン受容体.ステロイドによる糖代謝悪化を検出できるのか?-.2011
- Author(s)
  本島寛之, 湯浅智之, 堤厚之, 井形元維, 近藤龍也, 河島淳司, 松村剛, 福永麻希子, 前田貴子, 川崎修二, 花谷聡子, 石井規夫, 下田誠也, 古川昇, 水流添覚, 西川武志, 蛯名洋介, 荒木栄一
- Organizer
  第54回日本糖尿病学会総会
- Place of Presentation
  さっぽろ芸術文化の館・その他,札幌
- Data Source
  KAKENHI-PROJECT-21591144
[Presentation] シンポジウム「慢性炎症と糖代謝異常」熱ショック応答経路とインスリン抵抗性2011
- Author(s)
  近藤龍也、松山利奈、宮川克俊、後藤理英子、本島寛之、河島淳司、古川昇、水流添覚、荒木栄一
- Organizer
  第54回日本糖尿病学会学術総会
- Place of Presentation
  札幌、ロイトン札幌
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 2型糖尿病における大血管合併症進展の指標としての血中単球数の有用性2011
- Author(s)
  松村剛, 竹田佳代, 本島寛之, 石井規夫, 嶋田さやか, 木下博之, 福田一起, 西川武志, 荒木栄一
- Organizer
  第54回日本糖尿病学会総会
- Place of Presentation
  さっぽろ芸術文化の館・その他,札幌
- Data Source
  KAKENHI-PROJECT-21591144
[Presentation] 2型糖尿病における末梢血単球数とIMT肥厚度との関連2010
- Author(s)
  松村剛, 本島寛之, 竹田佳代, 石井規夫, 木下博之, 福田一起, 西川武志, 荒木栄一
- Organizer
  第48回日本糖尿病学会九州地方会
- Place of Presentation
  別府ビーコンプラザ,大分
- Data Source
  KAKENHI-PROJECT-21591144
[Presentation] ミニシンポジウム「体質改善を主眼においた最新の生活習慣病治療法開発」熱ショック応答経路(HSR)活性化による生活習慣病治療2010
- Author(s)
  近藤龍也、松山利奈、後藤理英子、宮川克俊、河島淳司、本島寛之、西川武志、荒木栄一
- Organizer
  第60回日本体質医学会総会
- Place of Presentation
  熊本、熊本パレア
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 熱ショック応答経路(HSR)活性化によるメタボリックシンドローム治療成績2010
- Author(s)
  近藤龍也、松山利奈、後藤理英子、宮川克俊、河島淳司、本島寛之、西川武志、荒木栄一
- Organizer
  第48回日本糖尿病学会九州地方会
- Place of Presentation
  別府、ビーコンプラザ
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] メタボリックシンドロームに対する温熱・電流同時印加療法(MET)の内臓脂肪減少・代謝改善・慢性炎症マーカー低下効果2010
- Author(s)
  近藤龍也、佐々木一成、松山利奈、水流添覚、古川昇、本島寛之、河島淳司、古賀沙緒里、甲斐広文、荒木栄一
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山、岡山コンベンションセンター
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 糖代謝改善をもたらす分子シャペロンHsp72制御療法の臨床応用を目指して2010
- Author(s)
  近藤龍也、佐々木一成、松山利奈、水流添覚、本島寛、古賀沙緒里、甲斐広文、荒木栄一
- Organizer
  第107回日本内科学会総会
- Place of Presentation
  東京、東京国際フォーラ
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] Induction of HSP72, a Potential Novel Therapeutic Approach For Metabolic Syndrome and Type2Diabetes2010
- Author(s)
  Kondo T, Matsuyama R, Sasaki K, Morino-Koga S, Suico MA, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E
- Organizer
  46th EASD Annual Meeting 20～ 24 Sept
- Place of Presentation
  Stockholm, Sweden
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 短期血糖コントロール指標としての血中可溶性インスリン受容体αサブユニットの有用性2010
- Author(s)
  本島寛之
- Organizer
  第53回日本糖尿病学会年次学術集会
- Place of Presentation
  岡山
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22590987
[Presentation] タボリックシンドロームに対する熱ショック応答経路(HSR)活性化療法の臨床応用2010
- Author(s)
  近藤龍也、松山利奈、後藤理英子、宮川克俊、河島淳司、本島寛之、西川武志、荒木栄一
- Organizer
  第31回日本肥満学会
- Place of Presentation
  群馬、前橋テルサ
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] HMG-CoA reductase inhibitors ameliorate insulin resistance trough PPARγactivation2010
- Author(s)
  Matsumura T, Ishii N, Kinoshita H, Motoshima H, Murata Y, Tsuruzoe K, Nishikawa T, Araki E
- Organizer
  14th International Congress of Endocrinology
- Place of Presentation
  Kyoto International conference center, Kyoto, Japan, Poster
- Data Source
  KAKENHI-PROJECT-21591144
[Presentation] 短期血糖コントロール指標としての血中可溶性インスリン受容体αサブユニットの有用性2010
- Author(s)
  本島寛之, 湯浅智之, 西川武志, 下田誠也, 近藤龍也, 河島淳司, 松村剛, 後藤理英子, 大久保美那, 前田貴子, 竹田佳代, 山城武司, 川崎修二, 堤厚之, 石井規夫, 久木留大介, 古川昇, 水流添覚, 宮村信博, 蛯名洋介, 荒木栄一
- Organizer
  第53回日本糖尿病学会総会
- Place of Presentation
  ホテルグランヴィア岡山・岡山コンベンションセンター・その他,岡山
- Data Source
  KAKENHI-PROJECT-21591144
[Presentation] Knockdown of CHOP, an Inducer of Cellular Apoptosis upon Exesssive Endoplasmic Reticulum Stress, in Liver Ameliorates Insulin Resistance and Glucose Homeostasis in Mice Model of Type2Diabetes2009
- Author(s)
  Kondo T, Adachi H, Ogawa R, Sasaki K, Tsuruzoe K, Furukawa N, Motoshima H, Sakakida M, Araki E
- Organizer
  45th EASD Annual Meeting
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 血中インスリン受容体αサブユニット量は血糖コントロール指標となりえるか?2009
- Author(s)
  本島寛之, 西川武志, 湯浅智之, 河島淳司, 後藤理英子, 小野薫, 花谷聡子, 木下博之, 川崎修二, 堤厚之, 児島協, 松村剛, 近藤龍也, 宮村信博, 蛯名洋介, 荒木栄一
- Organizer
  第52回日本糖尿病学会総会
- Place of Presentation
  大阪国際会議場,大阪
- Data Source
  KAKENHI-PROJECT-21591144
[Presentation] アポトーシス誘導転写因子CHOPの発現制御によるインスリン抵抗性改善効果の検証2009
- Author(s)
  近藤龍也、足立博紀、小川れい、佐々木一成、古川昇、本島寛之、河島淳司、水流添覚、高野優、榊田典治、荒木栄一
- Organizer
  第52回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪、大阪国際会議場
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] 小胞体ストレス関連分子CHOPの発現制御によるインスリン抵抗性改善作用の検証2009
- Author(s)
  近藤龍也、足立博紀、小川れい、佐々木一成、古川昇、本島寛之、河島淳司、水流添覚、高野優、榊田典治、荒木栄一
- Organizer
  第47回日本糖尿病学会九州地方会
- Place of Presentation
  福岡、リーガロイヤルホテル小倉
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] Araki E2009
- Author(s)
  Kondo T, Adachi H, Ogawa R, Sasaki K, Tsuruzoe K, Furukawa N, Motoshima H, Sakakida M
- Organizer
  69th American Diabetes Association Scientific Sessions
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-21591145
[Presentation] ニフェジピンによるPPARγ活性化を介した抗動脈硬化作用機序の解明2008
- Author(s)
  松村剛, 石井規夫, 木下博之, 中尾紗綾, 本島寛之, 西川武志, 荒木栄一
- Organizer
  第31回日本高血圧学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19591056
[Presentation] スタチン製剤による抗動脈硬化作用の新規機序解明-PPARα, PPARγ活性誘導効果の関与2007
- Author(s)
  松村剛, 矢野美由紀, 石井則夫, 村田雄介, 竹田佳代, 瀬ノ口隆文, 本島寛之, 西川武志, 荒木栄一
- Organizer
  第50回日本糖尿病学会総会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591056
[Presentation] スタチンによるPPARα, PPARγを介した抗動脈硬化作用の解明2007
- Author(s)
  松村剛, 矢野美由紀, 石井則夫, 竹田佳代, 村田雄介, 瀬ノ口隆文, 本島寛之, 西川武志, 荒木栄一
- Organizer
  第39回日本動脈硬化学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591056
[Presentation] 肥満2型糖尿病におけるHDL亜分画とインスリン抵抗性との関連
- Author(s)
  松村剛, 木下博之, 本島寛之, 近藤龍也, 瀬ノ口隆文, 石井規夫, 福田一起, 山田沙梨恵, 村上彩子, 松嶋和美, 杉内博幸, 西川武志, 荒木栄一
- Organizer
  第35回日本肥満学会
- Place of Presentation
  宮崎
- Year and Date
  2014-10-24 – 2014-10-25
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] 熊本におけるブルーサークルメニュー（レストランが提供するヘルシー外食メニュー）開発―臨床効果の評価と普及への道のり―.
- Author(s)
  本島寛之, 村岡まき子, 高木優樹, 後藤理英子, 下村登貴子, 猪原淑子, 久木留大介, 池田知栄子, 河島淳司, 内田珠美, 澤田真治, 松岡友里, 吉村栄, 山内信吾, 岸川秀樹, 柿村葉子, 荒木栄一
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461360
[Presentation] Association between circulating leukocyte subtype counts and carotid intima-media thickness in Japanese subjects with type 2 diabetes.
- Author(s)
  Matsumura T, Senokuchi T, Fukuda K, Ishii N, Kinoshita H, Yamada S, Murakami S, Kondo T, Motoshima H, Nishikawa T, Araki E
- Organizer
  The 6th AASD Scientific Meeting
- Place of Presentation
  SUNTEC, Singapore
- Year and Date
  2014-12-21 – 2014-12-24
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] Statins improve glucose tolerance in high fat-fed mice possible through PPARγ activation in adipocytes.
- Author(s)
  Fukuda K, Matsumura T, Ishii N, Kinoshita H, Yamada S, Murakami S, Senokuchi T, Kondo T, Motoshima H, Nishikawa T, Araki E
- Organizer
  The 9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-09-12 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-25461374
[Presentation] Statin-mediated PPARγ activation in adipocytes may improve glucose tolerance in high fat-fed mice.
- Author(s)
  Senokuchi T, Matsumura T, Fukuda K, Ishii N, Kinoshita H, Yamada S, Murakami S, Kondo T, Motoshima H, Nishikawa T, Araki E
- Organizer
  The 6th AASD Scientific Meeting
- Place of Presentation
  SUNTEC, Singapore
- Year and Date
  2014-12-21 – 2014-12-24
- Data Source
  KAKENHI-PROJECT-25461374

1. MATSUMURA Takeshi (20398192)

# of Collaborated Projects: 9 results

# of Collaborated Products: 64 results
2. KONDO Tatsuya (70398204)

# of Collaborated Projects: 6 results

# of Collaborated Products: 55 results
3. NISHIKAWA Takeshi (70336212)

# of Collaborated Projects: 5 results

# of Collaborated Products: 24 results
4. ARAKI Eiichi (10253733)

# of Collaborated Projects: 3 results

# of Collaborated Products: 43 results
5. MIYAMURA Nobuhiro (40274716)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. TSURUZOE Kaku (50398202)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
7. Igata Motoyuki (40599099)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
8. SENOKUCHI Takafumi (00530320)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
9. NISHIDA Kenro (50336244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田口哲也 (30398200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KUKIDOME Daisuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 石井規夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. メリー・アンスイコ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MOTOSHIMA Hiroyuki 本島 寛之

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Inhibitory effect of TACE on WAT browningPrincipal Investigator

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Shedding of TNF receptors in adipose tissues and insulin resistancePrincipal Investigator

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TNFa変換酵素を介したインスリン抵抗性発現機序の解析Principal Investigator

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[Book] AMPキナーゼと動脈硬化.内分泌・糖尿病・代謝内科2011

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[Journal Article] Impact of hepatic HSP72 on insulin signaling2019

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[Journal Article] Identification of microRNA that represses IRS-1 expression in liver.2018

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[Journal Article] Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis.2018

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MOTOSHIMA Hiroyuki 本島寛之