Saito Mineki 齊藤峰輝

… Alternative Names

SAITO Mineki 齊藤峰輝

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Researcher Number	40398285
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 川崎医科大学, 医学部, 教授 2012 – 2020: 川崎医科大学, 医学部, 教授 2011: 琉球大学, 大学院・医学研究科, 准教授 2010 – 2011: 琉球大学, 医学研究科, 准教授 2009: University of the Ryukyus, 医学部, 准教授 2006: Kanazawa Medical University, Associate Professor, 医学部, 助教授 2005: 鹿児島大学, 医学部・歯学部附属病院, 医員
Review Section/Research Field	Principal Investigator Neurology / Virology / Basic Section 54030:Infectious disease medicine-related / Basic Section 52020:Neurology-related
Keywords	Principal Investigator HTLV-1 / 感染防御 / 免疫老化 / 慢性炎症 / HBZ / HAM / 免疫学 / ワクチン / T細胞 / ATL … More / 自己抗原特異的T細胞 / T細胞受容体 / 動物モデル / HAM/TSP / 自己抗体 / Clinical / Immunology / Human Genetics / Neurological disease / Virus / 臨床 / 遺伝子 / 脳神経疾患 / ウイルス / ヒト化マウス Less

Elucidation of the pathogenesis of HTLV-1-related diseases with a focus on immune aging and development of novel preventive and therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  齊藤峰輝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kawasaki Medical School
A comparative analysis of HAM/TSP using novel animal model and patients samples for understanding pathogenesis and identifying potential targets for future therapy.Principal Investigator
- Principal Investigator
  
  Saito Mineki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kawasaki Medical School
Investigation on molecular mechanisms of HAM/TSP pathogenesis mediated by the interactions between HBZ and its target host factors.Principal Investigator
- Principal Investigator
  
  Saito Mineki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kawasaki Medical School
Analysis of chronic inflammation caused by HTLV-1 infection and development of novel strategies to prevent HTLV-1 associated diseases.Principal Investigator
- Principal Investigator
  
  SAITO Mineki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kawasaki Medical School
The use of novel humanized mouse model for the study of immunotherapy against HTLV-1 infectionPrincipal Investigator
- Principal Investigator
  
  SAITO Mineki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  University of the Ryukyus
Clinical Investigation for Virus-Host Interactions and its Implication in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).Principal Investigator
- Principal Investigator
  
  SAITO Mineki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Kanazawa Medical University
  Kagoshima University

[Book] Reference Module in Life Sciences2017
- Author(s)
  Saito M.
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-15K09345
[Book] Encyclopedia of Genetics 2nd Edition2013
- Author(s)
  Saito M.
- Total Pages
  4368
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-24590556
[Book] HTLV-1. Encyclopedia of Genetics 2nd Edition2012
- Author(s)
  Saito M.
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-21590512
[Book] HTLV-Iと疾患(分担) HAM/TSPの免疫遺伝学2007
- Author(s)
  齊藤峰輝
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-17590886
[Book] HTLV-1と疾患(分担) HAM/TSPの免疫遺伝学2007
- Author(s)
  齊藤峰輝
- Total Pages
  263
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590886
[Journal Article] Genome wide association study of HTLV-1 associated myelopathy/tropical spastic paraparesis in the Japanese population2021
- Author(s)
  Penova Marina et al.
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 11
- DOI
  10.1073/pnas.2004199118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07349, KAKENHI-PROJECT-19K07983, KAKENHI-PROJECT-19H03689, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K07541, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20K22879, KAKENHI-PROJECT-20H03514, KAKENHI-PROJECT-20K07890, KAKENHI-PROJECT-16K18474
[Journal Article] Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis2020
- Author(s)
  Kodama Daisuke, Tanaka Masakazu, Matsuzaki Toshio, Izumo Kimiko, Nakano Nobuaki, Matsuura Eiji, Saito Mineki, Nagai Masahiro, Horiuchi Masahisa, Utsunomiya Atae, Takashima Hiroshi, Kubota Ryuji, Izumo Shuji
- Journal Title
  
  PLOS Neglected Tropical Diseases
  
  Volume: 14 Issue: 7 Pages: e0008361-e0008361
- DOI
  10.1371/journal.pntd.0008361
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07999, KAKENHI-PROJECT-18K07541
[Journal Article] Association between HTLV-1 genotypes and risk of HAM/TSP.2019
- Author(s)
  Saito M.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 10 Pages: 1101-1101
- DOI
  10.3389/fmicb.2019.01101
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07541
[Journal Article] EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.2019
- Author(s)
  Naito T, Ushirogawa H, Fukushima T, Tanaka Y, Saito M.
- Journal Title
  
  Virology Journal
  
  Volume: 16 Issue: 1 Pages: 160-160
- DOI
  10.1186/s12985-019-1270-1
- NAID
  120006937799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07541, KAKENHI-PROJECT-19K10602, KAKENHI-PROJECT-17K09170
[Journal Article] Association of high levels of plasma OX40 with acute adult T-cell leukemia.2019
- Author(s)
  Tanaka Y, Takahashi Y, Tanaka R, Miyagi T, Saito M, Fukushima T.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 109 Issue: 3 Pages: 319-327
- DOI
  10.1007/s12185-018-02580-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07541, KAKENHI-PROJECT-18K08303, KAKENHI-PROJECT-18K16066
[Journal Article] Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP.2018
- Author(s)
  Naito T, Yasunaga JI, Mitobe Y, Shirai K, Sejima H, Ushirogawa H, Tanaka Y, Nakamura T, Hanada K, Fujii M, Matsuoka M, Saito M.
- Journal Title
  
  Retrovirology
  
  Volume: 15 Issue: 1 Pages: 72-72
- DOI
  10.1186/s12977-018-0454-x
- NAID
  120006847301
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09822, KAKENHI-PROJECT-17K07166, KAKENHI-PROJECT-17K09170, KAKENHI-PROJECT-18K07541, KAKENHI-PROJECT-18H02420
[Journal Article] Diversity of cell phenotypes among MT-2 cell lines affects the growth of U937 cells and cytokine production2018
- Author(s)
  Nomura Hajime、Umekita Kunihiko、Hashikura Yuuki、Umeki Kazumi、Yamamoto Ikuo、Aratake Yatsuki、Saito Mineki、Hasegawa Hiroo、Yanagihara Katsunori、Okayama Akihiko
- Journal Title
  
  Human Cell
  
  Volume: 32 Issue: 2 Pages: 185-192
- DOI
  10.1007/s13577-018-00231-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-18K07541
[Journal Article] Influenza A virus hemagglutinin and neuraminidase act as novel motile machinery2017
- Author(s)
  Sakai, T. Nishimura, S. I. Naito,T. Saito, M.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 45043-45043
- DOI
  10.1038/srep45043
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670220, KAKENHI-PROJECT-15K19562, KAKENHI-PROJECT-15K09345
[Journal Article] Generation of a genetically stable high-fidelity influenza vaccine strain.2017
- Author(s)
  Naito T, Mori K, Ushirogawa H, Takizawa N, Nobusawa E, Odagiri T, Tashiro M, Ohniwa RL, Nagata K, Saito M.
- Journal Title
  
  Journal of Virology
  
  Volume: 91 Issue: 6 Pages: 614-614
- DOI
  10.1128/jvi.01073-16
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19562, KAKENHI-PROJECT-15K21607, KAKENHI-PROJECT-15K09345, KAKENHI-PROJECT-16J10490
[Journal Article] Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status2017
- Author(s)
  Shiohama Yasuo、Naito Tadasuke、Matsuzaki Toshio、Tanaka Reiko、Tomoyose Takeaki、Takashima Hiroshi、Fukushima Takuya、Tanaka Yuetsu、Saito Mineki
- Journal Title
  
  Virology Journal
  
  Volume: 14 Issue: 1 Pages: 130-130
- DOI
  10.1186/s12985-017-0802-9
- NAID
  120006849690
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09170, KAKENHI-PROJECT-15K09345
[Journal Article] The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis2017
- Author(s)
  Saito Mineki、Sejima Hiroe、Naito Tadasuke、Ushirogawa Hiroshi、Matsuzaki Toshio、Matsuura Eiji、Tanaka Yuetsu、Nakamura Tatsufumi、Takashima Hiroshi
- Journal Title
  
  Virology Journal
  
  Volume: 14 Issue: 1 Pages: 234-234
- DOI
  10.1186/s12985-017-0902-6
- NAID
  120006849689
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09170, KAKENHI-PROJECT-15K09345
[Journal Article] Human T-cell leukemia virus type I Tax genotype analysis in Okinawa, the southernmost and remotest islands of Japan: Different distributions compared with mainland Japan and the potential value for the prognosis of aggressive adult T-cell leukemia/lymphoma2017
- Author(s)
  Sakihama Shugo、Saito Mineki、Kuba-Miyara Megumi、Tomoyose Takeaki、Taira Naoya、Miyagi Takashi、Hayashi Masaki、Kinjo Shigeko、Nakachi Sawako、Tedokon Iori、Nishi Yukiko、Tamaki Keita、Morichika Kazuho、Uchihara Jun-nosuke、Morishima Satoko、Karube Ken-nosuke、Tanaka Yuetsu、Masuzaki Hiroaki、Fukushima Takuya
- Journal Title
  
  Leuk Res
  
  Volume: 61 Pages: 18-24
- DOI
  10.1016/j.leukres.2017.08.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09839, KAKENHI-PROJECT-15K08371, KAKENHI-PROJECT-15K09345
[Journal Article] HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.2016
- Author(s)
  Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.
- Journal Title
  
  J Neurovirol.
  
  Volume: in press Issue: 4 Pages: 416-430
- DOI
  10.1007/s13365-015-0407-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-15K09345
[Journal Article] Absolute quantification of HTLV-1 basic leucine zipper factor (HBZ) protein and its plasma antibody in HTLV-1 infected individuals with different clinical status.2016
- Author(s)
  Shiohama Y, Naito T, Matsuzaki T, Tanaka R, Tomoyose T, Takashima H, Fukushima T, Tanaka Y, Saito M.
- Journal Title
  
  Retrovirology
  
  Volume: 13 Issue: 1 Pages: 1-14
- DOI
  10.1186/s12977-016-0263-z
- NAID
  120006847302
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19562, KAKENHI-PROJECT-15K09345
[Journal Article] HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.2015
- Author(s)
  Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.
- Journal Title
  
  Journal of Neurovirology
  
  Volume: Dec 3.　Epub ahead of print.
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09345
[Journal Article] Pathogenic conversion of Foxp3+ T cells into Th17 cells: is this also the case for multiple sclerosis?2014
- Author(s)
  Saito M.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 5 Issue: 2 Pages: 112-113
- DOI
  10.1111/cen3.12114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590556
[Journal Article] Pathogenic conversion of Foxp3+ T cells into Th17 cells: is this also the case for multiple sclerosis?2014
- Author(s)
  Saito M
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: N/A
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590556
[Journal Article] Neuroimmunological aspects of human T cell leukemia virus type 1- associated myelopathy/tropical spastic paraparesis.2014
- Author(s)
  Saito M.
- Journal Title
  
  J Neurovirol
  
  Volume: 20 Issue: 2 Pages: 164-174
- DOI
  10.1007/s13365-013-0192-8
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590556
[Journal Article] The neutralizing function of the anti-HTLV-1 antibody is essential in preventing in vivo transmission of HTLV-1 to human T cells in NOD-SCID/γcnull (NOG) mice.2014
- Author(s)
  Saito M, Tanaka R, Fujii H, Kodama A, Takahashi Y, Matsuzaki T, Takashima H, Tanaka Y.
- Journal Title
  
  Retrovirology
  
  Volume: 11 Issue: 1 Pages: 74-74
- DOI
  10.1186/s12977-014-0074-z
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590556, KAKENHI-PROJECT-221S0001
[Journal Article] Elimination of human T cell leukemia virus type-1-infected cells by neutralizing and antibody-dependent cellular cytotoxicity-inducing antibodies against human T cell leukemia virus type-1 envelope gp46.2014
- Author(s)
  Tanaka Y, Takahashi Y, Tanaka R, Kodama A, Fujii H, Hasegawa A, Kannagi M, Ansari AA, Saito M.
- Journal Title
  
  AIDS Research and Human Retroviruses
  
  Volume: N/A Issue: 6 Pages: 542-552
- DOI
  10.1089/aid.2013.0214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590556, KAKENHI-PROJECT-221S0001
[Journal Article] A novel and simple method for generation of human dendritic cells from unfractionated peripheral blood mononuclear cells within 2 days: its application for induction of HIV-1-reactive CD4 (+) T cells in the hu-PBL SCID mice.2013
- Author(s)
  Kodama A, Tanaka R, Saito M, Ansari AA, Tanaka Y.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 4 Pages: 292-292
- DOI
  10.3389/fmicb.2013.00292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590556
[Journal Article] Increased expression of OX40 is associated with progressive disease in patients with HTLV-1- associated myelopathy/tropical spastic paraparesis.2013
- Author(s)
  Saito M, Tanaka R, Arishima S, Matsuzaki T, Ishihara S, Tokashiki T, Ohya Y, Takashima H, Umehara F, Izumo S, Tanaka Y.
- Journal Title
  
  Retrovirology
  
  Volume: 10 Issue: 1 Pages: 51-51
- DOI
  10.1186/1742-4690-10-51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590556, KAKENHI-PROJECT-221S0001
[Journal Article] Immunopathogenesis of Human T-cell leukemia virus type 1(HTLV-1)-associated myelopathy/tropical spastic paraparesis(HAM/TSP): Recent perspectives2012
- Author(s)
  Saito M, Bangham CR.
- Journal Title
  
  Leukemia Research and Treatment
  
  Volume: 2012 Pages: 1-1
- DOI
  10.1155/2012/123637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses2012
- Author(s)
  Adachi T, Tanaka R, Kodama A, Saito M, Takahashi Y, Ansari AA, Tanaka Y.
- Journal Title
  
  Retro virology
  
  Volume: 8 Pages: 84-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses2012
- Author(s)
  Adachi T, Tanaka R, Kodama A, Saito M, et al
- Journal Title
  
  Retrovirology
  
  Volume: 8 Issue: 1
- DOI
  10.1186/1742-4690-8-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] Immunopathogenesis of Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) : Recent perspectives2012
- Author(s)
  Saito M, Bangham CR
- Journal Title
  
  Leukemia Research and Treatment
  
  Volume: Article ID Pages: 259045-259045
- DOI
  10.1155/2012/259045
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512, KAKENHI-PROJECT-24590556
[Journal Article] Immunogenetics and the pathological mechanisms of human T-cell leukemia virus type 1-(HTLV-1)-associated myelopathy/tropical spastic paraparesis(HAM/TSP)2010
- Author(s)
  Saito M.
- Journal Title
  
  Interdisciplinary Perspectives on Infectious Diseases
  
  Volume: 2010 Pages: 1-8
- DOI
  10.1155/2010/478461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1(HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells2010
- Author(s)
  Saito K, Saito M, Taniura N, Okuwa T, Ohara Y.
- Journal Title
  
  Virology
  
  Volume: 403 Pages: 173-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] HAM/TSP病態研究の最近の進歩2010
- Author(s)
  齊藤峰輝
- Journal Title
  
  血液・腫瘍科
  
  Volume: 60 Pages: 642-650
- NAID
  40019064467
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bc13 expression, which is associated with enhanced growth of HTLV-1-infected T cells.2010
- Author(s)
  Saito K, Saito M, et al.
- Journal Title
  
  Virology
  
  Volume: 403 Pages: 173-180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] Immunogenetics and the pathological mechanisms of human T-cell leukemia virus type 1-(HTLV-1)-associated myelopathy/tropical spastic paraparesis(HAM/TSP)2010
- Author(s)
  齊藤峰輝
- Journal Title
  
  Interdisciplinary Perspectives on Infectious Diseases Article ID 478461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] HAM/TSPの病態に関する最近の考え方2009
- Author(s)
  齊藤峰輝
- Journal Title
  
  血液・腫瘍科
  
  Volume: 56 Pages: 600-606
- NAID
  40019064284
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis(HAM/TSP)2009
- Author(s)
  Saito M, Matsuzaki T, Satou Y, Yasunaga J, Saito K, Arimura K, Matsuoka M, Ohara Y.
- Journal Title
  
  Retro virology
  
  Volume: 6 Pages: 19-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] HAM/TSPの病態に関する最近の考え方2009
- Author(s)
  齊藤峰輝
- Journal Title
  
  血液・腫瘍科 58
  
  Pages: 600-606
- NAID
  40019064284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] Immunogenetics of human T-cell leukemia virus type 1(HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP)2009
- Author(s)
  齊藤峰輝
- Journal Title
  
  Inflammation and Regeneration 29
  
  Pages: 310-316
- NAID
  10026094043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590512
[Journal Article] Flow cytometry evaluation of the T-cell receptor Vβ repertoire among human T-cell lymphotropic virus type-1 (HTLV-1) infected individuals : effect of interferon alpha therapy in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).2006
- Author(s)
  Saito M
- Journal Title
  
  Journal of the Neurological Sciences 246(1-2)
  
  Pages: 37-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590886
[Journal Article] Flow cytometry evaluation of the T-cell receptor Vβ repertoire among human T-cell lymphotropic virus type-1 (HTLV-1) infected individuals : effect of interferon alpha therapy in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).2006
- Author(s)
  Saito M et al.
- Journal Title
  
  Journal of the Neurological Sciences 246(1-2)
  
  Pages: 37-43
- Data Source
  KAKENHI-PROJECT-17590886
[Journal Article] Flow cytometry evaluation of the T-cell receptor Vβ repertoire among human T-cell lymphotropic virus type-1 (HTLV-1) infected individuals : effect of interferon alpha therapy in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).2006
- Author(s)
  Saito M
- Journal Title
  
  Journal of the Neurological Sciences 246 (1-2)
  
  Pages: 37-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590886
[Journal Article] ApaI polymorphism of vitamin D receptor gene is associated with susceptibility to HTLV-1 associated myelopathy/tropical spastic paraparesis in HTLV-1 infected individuals.2005
- Author(s)
  Saito M, et al.
- Journal Title
  
  Journal of the Neurological Sciences 232・1-2
  
  Pages: 29-35
- Data Source
  KAKENHI-PROJECT-17590886
[Patent] ヒトT細胞白血病ウイルスHBZ蛋白質の検出方法2014
- Inventor(s)
  塩浜康雄、齊藤峰輝
- Industrial Property Rights Holder
  塩浜康雄、齊藤峰輝
- Industrial Property Rights Type
  特許
- Filing Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] HTLV-1サブグループによるHAM感受性の違い2019
- Author(s)
  齊藤峰輝, 後川潤, 内藤忠相
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07541
[Presentation] 免疫老化を制御するMenin-Bach2経路にHTLV-1が及ぼす影響の解析2018
- Author(s)
  瀬島寛恵, 内藤忠相, 齊藤峰輝
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07541
[Presentation] Establishment of a novel small animal model for HAM/TSP.2017
- Author(s)
  Ushirogawa H, Arishima S, Yasunaga J, Kubota R, Ohshima K, Izumo S, Matsuoka M, Saito M.
- Organizer
  The 18th International Conference on Human Retrovirology: HTLV and Related Viruses.
- Place of Presentation
  Hotel Grand Arc Hanzomon, Tokyo, Japan.
- Year and Date
  2017-03-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] HAM発症リスクに関連するHTLV-1遺伝子型特異的な宿主遺伝子の発現制御メカニズムの解析2017
- Author(s)
  内藤忠相、齊藤峰輝
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] Plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status.2017
- Author(s)
  Mineki Saito, Yasuo Shiohama, Tadasuke Naito, Toshio Matsuzaki, Eiji Matsuura, Reiko Tanaka, Takeaki Tomoyose, Takuya Fukushima, Hiroshi Takashima, Yuetsu Tanaka
- Organizer
  The 18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] Molecular analysis of HTLV-1 subgroups associated with the development of HAM/TSP.2017
- Author(s)
  Tadasuke Naito, Mineki Saito
- Organizer
  The 18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] The role of CC chemokine ligand (CCL) 1 targeted by Tax in HAM/TSP.2017
- Author(s)
  Sejima H, Matsuzaki T, Matsuura E, Takashima H, Saito M.
- Organizer
  The 18th International Conference on Human Retrovirology: HTLV and Related Viruses.
- Place of Presentation
  Hotel Grand Arc Hanzomon, Tokyo, Japan.
- Year and Date
  2017-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] 遺伝子改変マウスを用いたHAM病態モデル動物の作製2017
- Author(s)
  後川潤，有島志保，安永純一朗，久保田龍二, 大島孝一，出雲周二，松岡雅雄，齊藤峰輝
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] HAM/TSPにおけるTaxターゲット遺伝子CCL1の病因的意義2017
- Author(s)
  瀬島寛恵, 松崎敏男, 松浦英治, 髙嶋博, 齊藤峰輝
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] Plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status.2017
- Author(s)
  Saito M, Shiohama Y, Naito T, Matsuzaki T, Matsuura E, Tanaka R, Tomoyose T, Fukushima T, Takashima H, Tanaka Y
- Organizer
  The 18th International Conference on Human Retrovirology: HTLV and Related Viruses.
- Place of Presentation
  Hotel Grand Arc Hanzomon, Tokyo, Japan.
- Year and Date
  2017-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] Molecular analysis of HTLV-1 subgroups associated with the development of HAM/TSP.2017
- Author(s)
  Naito T, Saito M.
- Organizer
  The 18th International Conference on Human Retrovirology: HTLV and Related Viruses.
- Place of Presentation
  Hotel Grand Arc Hanzomon, Tokyo, Japan.
- Year and Date
  2017-03-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] HTLV-1感染症における抗NY-ESO-1自己抗体の臨床的意義2016
- Author(s)
  齊藤峰輝、塩浜康雄、内藤忠相、松崎敏男、友寄毅昭、高嶋博、福島卓也、田中勇悦
- Organizer
  第3回日本HTLV-1学会学術集会
- Place of Presentation
  鹿児島県市町村自治会館（鹿児島市）
- Year and Date
  2016-08-27
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] 5.HAM発症感受性を規定するウイルス型特異的転写制御因子の機能解析2016
- Author(s)
  齊藤峰輝、後川潤、内藤忠相
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸コンベンションセンター（神戸市）
- Year and Date
  2016-05-21
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] HAM発症関連ウイルス型が疾患感受性を規定する分子機構の解析2015
- Author(s)
  齊藤峰輝、内藤忠相、水戸部悠一、安間恵子、松岡雅雄
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  長良川国際会議場（岐阜市）
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] HTLV-1の炎症原因遺伝子HBZによるHAM発症機構の解明とその制御2015
- Author(s)
  齊藤峰輝、塩浜康雄、後川潤、内藤忠相
- Organizer
  第56回日本神経学会学術総会
- Place of Presentation
  新潟コンベンションセンター（新潟市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] Molecular and clinical analyses of HTLV‐1 subgroups associated with the risk of developing HAM/TSP.2015
- Author(s)
  Mineki Saito, Keiko Yasuma, Tadasuke Naito, Toshio Matsuzaki, Yuichi Mitobe, Yoshihisa Yamano, Hiroshi Takashima, Masao Matsuoka.
- Organizer
  17th International Conference on Human Retrovirology: HTLV & Related Viruses.
- Place of Presentation
  Trois Ilets, Martinique.
- Year and Date
  2015-06-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09345
[Presentation] ヒトリンパ球移植免疫不全マウス(hu-PBL-SCID)を用いた新規HTLV-1感染動物モデル作製の試み2011
- Author(s)
  齊藤峰輝、田中礼子、児玉晃、田中勇悦
- Organizer
  第4回HTLV-1研究会
- Place of Presentation
  東京
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] HTLV-1関連脊髄症(HAM)におけるOX40陽性細胞の解析とHTLV-1感染ヒト化マウス作製の試み2011
- Author(s)
  齊藤峰輝、田中礼子、児玉晃、田中勇悦
- Organizer
  第64回日本細菌学会九州支部総会・第48回日本ウイルス学会九州支部総会
- Place of Presentation
  北九州市
- Year and Date
  2011-08-26
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] Successful development of novel monoclonal antibodies against HTLV-1 bZIP factor and their applications in studying the pathogenesis of HAM/TSP2011
- Author(s)
  Mineki Saito
- Organizer
  15th International Conference on Human Retroviruses : HTLV and Related Viruses
- Place of Presentation
  Leuven, Belgium
- Year and Date
  2011-06-06
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] HTLV-1関連脊髄症(HAM)におけるHBZ遺伝子発現の意義2011
- Author(s)
  齊藤峰輝、田中礼子、児玉晃、松崎敏男、田中勇悦
- Organizer
  第23回日本神経免疫学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] HTLV-1関連脊髄症におけるOX40陽性T細胞の意義2010
- Author(s)
  齊藤峰輝
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  あわぎんホール(徳島市)
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] Successful development of novel monoclonal antibodies against HTLV-1 bZIP factor and their applications in studying the pathogenesis of HAM/TSP2010
- Author(s)
  Saito M, Tanaka R, Kodama A, Matsuzaki T, Suehara M, Tanaka Y
- Organizer
  15th International Conference on Human Retroviruses : HTLV and Related Viruses
- Place of Presentation
  Leuven, Belgium
- Year and Date
  2010-06-06
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] Enhanced expression of OX40 by HTLV-1 Tax and its roles in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP)2010
- Author(s)
  Saito M, Tanaka R, Matsuzaki T, Umehara F, Tanaka Y
- Organizer
  The 10th International Symposium on Neuro Virology
- Place of Presentation
  Milan, Italy
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] HTLV-1 bZIP Factor(HBZ)に対する抗体作製とHAM臨床検体を用いた解析2010
- Author(s)
  齊藤峰輝
- Organizer
  第3回HTLV-1研究会・合同班会議
- Place of Presentation
  東京大学医科学研究所(東京都)
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] HTLV-1関連脊髄症におけるOX40陽性T細胞の意義2010
- Author(s)
  齊藤峰輝
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京都)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] Enhanced expression of OX40 by HTLV-1 Tax and its roles in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)2010
- Author(s)
  Mineki Saito
- Organizer
  The 10th International Symposium on NeuroVirology
- Place of Presentation
  University of Milan, Italy.
- Year and Date
  2010-10-13
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] HAM, ATL治療標的候補分子Bc1-3のHTLV-1感染による高発現機構の解析と制御法の検討2009
- Author(s)
  齊藤峰輝
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] HTLV-1関連脊髄症(HAM/TSP)におけるOX40陽性T細胞の意義2009
- Author(s)
  齊藤峰輝
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  都市センターホテル(東京都)
- Year and Date
  2009-10-27
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] HTLV-1関連脊髄症(HAM)におけるOX40陽性T細胞の意義2009
- Author(s)
  齊藤峰輝
- Organizer
  第2回HTLV-1研究会・合同班会議
- Place of Presentation
  東京大学医科学研究所(東京都)
- Year and Date
  2009-08-29
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] シンポジウム「ATLとHTLV-1研究の最前線」HAM/TSPの病態2009
- Author(s)
  齊藤峰輝
- Organizer
  第49回日本リンパ網内系学会総会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2009-07-10
- Data Source
  KAKENHI-PROJECT-21590512
[Presentation] Complete prevention of HTLV-1 infection in humanized mice (hu-PBL SCID) by a neutralizing monoclonal antibody to envelope gp46.
- Author(s)
  Saito M, Tanaka R, Kodama A, Tanaka Y.
- Organizer
  16th International Conference on Human Retrovirology: HTLV and Related Viruses.
- Place of Presentation
  Montréal, Canada.
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] ヒトT細胞白血病ウイルス1型（HTLV-1）感染予防法と新規HAM治療薬の検討
- Author(s)
  齊藤峰輝、塩浜康雄、後川潤、田中勇悦
- Organizer
  第26回神経免疫・第19回神経感染症合同学術集会
- Place of Presentation
  金沢歌劇座・金沢
- Year and Date
  2014-09-04 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] HTLV-1関連脊髄症発症関連ウイルス多型とHBZ、FoxP3遺伝子発現の解析
- Author(s)
  齊藤峰輝、田中礼子、田中勇悦
- Organizer
  第24回日本神経免疫学会学術集会
- Place of Presentation
  軽井沢プリンスホテルウエスト（長野県北佐久郡軽井沢町）
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] HTLV-1標的遺伝子CCL1のHAM発症における病因的意義
- Author(s)
  齊藤峰輝、塩浜康雄、後川潤、高嶋博、大原義朗
- Organizer
  第25回日本神経免疫学会学術集会
- Place of Presentation
  山口県国際総合センター (下関市）
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] HTLV-1遺伝子およびサイトカイン発現抑制効果を指標としたHAM治療薬・抗体医薬の検討
- Author(s)
  齊藤峰輝、塩浜康雄、後川　潤
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場・福岡
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] Complete prevention of HTLV-1 infection in humanized mice by a neutralizing monoclonal antibody to envelope gp46.
- Author(s)
  Saito M, Tanaka R, Kodama A, Tanaka Y.
- Organizer
  11th International Symposium on Neurovirology.
- Place of Presentation
  Grand Hyatt New York （New York, USA）
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] HAM発症関連ウイルス多型が宿主・ウイルス遺伝子発現および臨床経過に及ぼす影響の解析
- Author(s)
  齊藤峰輝、安間恵子、松崎敏男、髙嶋博、松岡雅雄
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京大学医科学研究所・東京
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] 抗HTLV-1gp46中和抗体によるHTLV-1関連脊髄症に対する新規治療法開発の試み
- Author(s)
  齊藤峰輝、田中礼子、児玉　晃、田中勇悦
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都）
- Data Source
  KAKENHI-PROJECT-24590556
[Presentation] HTLV-1関連脊髄症発症関連因子としてのHTLV-1ウイルス型の解析
- Author(s)
  齊藤峰輝、安間恵子、後川潤、松崎敏男、高嶋博、松岡雅雄
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都）
- Data Source
  KAKENHI-PROJECT-24590556

1. TANAKA Yuetsu (30163588)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
2. FURUKAWA Yoshitaka (00359978)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. ITO Toshihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. NAITO Tadasuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. TANAKA Masakazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. YAMANO Yoshihisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. HASEGAWA Hiroo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 堺立也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 藤井雅寛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 斎藤孔良

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 久保田龍二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 松浦英治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 柳原克紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 斎藤益満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 益崎裕章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saito Mineki 齊藤 峰輝

SAITO Mineki 齊藤 峰輝

Research Projects

Research Products

Co-Researchers

Elucidation of the pathogenesis of HTLV-1-related diseases with a focus on immune aging and development of novel preventive and therapeutic strategiesPrincipal Investigator

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A comparative analysis of HAM/TSP using novel animal model and patients samples for understanding pathogenesis and identifying potential targets for future therapy.Principal Investigator

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Investigation on molecular mechanisms of HAM/TSP pathogenesis mediated by the interactions between HBZ and its target host factors.Principal Investigator

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Analysis of chronic inflammation caused by HTLV-1 infection and development of novel strategies to prevent HTLV-1 associated diseases.Principal Investigator

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The use of novel humanized mouse model for the study of immunotherapy against HTLV-1 infectionPrincipal Investigator

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Clinical Investigation for Virus-Host Interactions and its Implication in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).Principal Investigator

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[Book] Reference Module in Life Sciences2017

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[Book] Encyclopedia of Genetics 2nd Edition2013

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[Book] HTLV-1. Encyclopedia of Genetics 2nd Edition2012

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[Book] HTLV-Iと疾患(分担) HAM/TSPの免疫遺伝学2007

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[Book] HTLV-1と疾患(分担) HAM/TSPの免疫遺伝学2007

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[Journal Article] Genome wide association study of HTLV-1 associated myelopathy/tropical spastic paraparesis in the Japanese population2021

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[Journal Article] Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis2020

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[Journal Article] Association between HTLV-1 genotypes and risk of HAM/TSP.2019

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[Journal Article] EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses.2019

Saito Mineki 齊藤峰輝

SAITO Mineki 齊藤峰輝