Miki Tsuyoshi 三木剛志

… Alternative Names

MIKI Tsuyoshi 三木剛志

三木剛志ミキツヨシ

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Researcher Number	40398582
Affiliation (Current)	2025: 北里大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 北里大学, 薬学部, 講師 2013 – 2018: 北里大学, 薬学部, 講師 2009 – 2011: 北里大学, 薬学部, 助教 2005 – 2006: 北里大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) / Bacteriology (including Mycology) Except Principal Investigator Bacteriology (including Mycology)
Keywords	Principal Investigator サルモネラ / 細菌 / 腸炎 / 抗菌レクチン / 病原性 / REG3 / 遺伝子発現 / 転写因子 / 第二鞭毛 / 脂肪酸代謝 … More / フラジェリン / 鞭毛運動 / 腸管内定着 / 脂肪酸 / 腸内細菌 / 感染症 / 病原体排除 / ビタミン / Bacteroides属細菌 / サルモネラ腸炎 / RegIIIbeta / ビタミンB6 / バクテロイデス属細菌 / 感染性腸炎 / 腸内細菌叢 / 細菌性腸炎 / DsbA / 酸化還元酵素 / シャペロン / III型分泌機構 / ゲノム … More Except Principal Investigator SPI-2 / III型分泌装置 / サルモネラ / III型分泌機構 / サルモネラ感染症 / 病原性 Less

病原菌感染におけるREG3の新たな役割Principal Investigator
- Principal Investigator
  
  三木剛志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kitasato University
Role of fatty acid metabolism in Salmonella pathogenesisPrincipal Investigator
- Principal Investigator
  
  Miki Tsuyoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Kitasato University
Role of the bactericidal lectin RegIIIbeta in Salmonella gut infectionPrincipal Investigator
- Principal Investigator
  
  Miki Tsuyoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Kitasato University
Role of the bactericidal lectin in bacterial enterocolitisPrincipal Investigator
- Principal Investigator
  
  Miki Tsuyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Kitasato University
ペリプラズム酸化還元酵素によるサルモネラ属細菌の病原性発現に関する研究Principal Investigator
- Principal Investigator
  
  三木剛志
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University
Functional characterization of type III secretion apparatus STM1410 encoded by Salmonella pathogenicity island 2
- Principal Investigator
  
  OKADA Nobuhiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University
ゲノム情報を利用したサルモネラIII型分泌機構エフェクターの網羅的同定と機能解析Principal Investigator
- Principal Investigator
  
  三木剛志
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Kitasato University

All 2024 2023 2022 2018 2017 2014 2013 2011 2010 2009

All Journal Article Presentation Book

[Book] 臨床免疫・アレルギー科2017
- Author(s)
  三木剛志
- Total Pages
  454
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16K08783
[Journal Article] Possible link between colonization of the gastrointestinal tract by Citrobacter rodentium in C57BL/6 mice and microbiota composition2024
- Author(s)
 Miki Tsuyoshi、Haneda Takeshi、Okada Nobuhiko、Ito Masahiro
- Journal Title
 
 Microbiology and Immunology
 
 Volume: na Issue: 6 Pages: 206-211
- DOI
 10.1111/1348-0421.13128
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K07011, KAKENHI-PROJECT-21K07030
[Journal Article] The CpxRA two-component system of adherent and invasive Escherichia coli contributes to epithelial cell invasion and early-stage intestinal fitness in a dysbiotic mouse model mediated by type 1 fimbriae expression2024
- Author(s)
 Miki Tsuyoshi、Ito Masahiro、Okada Nobuhiko、Haneda Takeshi
- Journal Title
 
 Infection and Immunity
 
 Volume: na Issue: 6
- DOI
 10.1128/iai.00132-24
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K07011, KAKENHI-PROJECT-21K07030
[Journal Article] uvrY Deletion and Acetate Reduce Gut Colonization of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli by Decreasing Expression of Type 1 Fimbriae2022
- Author(s)
 Miki Tsuyoshi、Hoshino Yusuke、Sudo Naoki、Ito Masahiro、Haneda Takeshi、Okada Nobuhiko
- Journal Title
 
 Infection and Immunity
 
 Volume: 90 Issue: 3
- DOI
 10.1128/iai.00662-21
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-18K07119, KAKENHI-PROJECT-19K07543, KAKENHI-PROJECT-21K07011, KAKENHI-PROJECT-21K07030, KAKENHI-PROJECT-20K16248, KAKENHI-PROJECT-21K05367
[Journal Article] Fatty acid homeostasis tunes flagellar motility by activating phase 2 flagellin expression, contributing to Salmonella gut colonization2022
- Author(s)
  Yusuke Hoshino, Taro Sakamoto, Naoki Sudo, Masahiro Ito, Takeshi Haneda, Nobuhiko Okada, Tsuyoshi Miki
- Journal Title
  
  Infection and Immunity
  
  Volume: 90 (7) Issue: 7
- DOI
  10.1128/iai.00184-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07011, KAKENHI-PROJECT-21K07030, KAKENHI-PROJECT-22K07073, KAKENHI-PROJECT-20K16248, KAKENHI-PROJECT-19K07543, KAKENHI-PROJECT-21K05367
[Journal Article] Tat-exported peptidoglycan amidase-dependent cell division contributes to Salmonella Typhimurium fitness in the inflamed gut2018
- Author(s)
  Fujimoto Mayuka、Goto Ryosuke、Hirota Riku、Ito Masahiro、Haneda Takeshi、Okada Nobuhiko、Miki Tsuyoshi
- Journal Title
  
  PLOS Pathogens
  
  Volume: 14 Issue: 10 Pages: e1007391-e1007391
- DOI
  10.1371/journal.ppat.1007391
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08783
[Journal Article] Salmonella Typhimurium CpxRA two-component system contributes to gut colonization in Salmonella-induced colitis2018
- Author(s)
  Mayuka Fujimoto, Ryosuke Goto, Takeshi Haneda, Nobuhiko Okada, and Tsuyoshi Miki
- Journal Title
  
  Infection and Immunity
  
  Volume: 00 Issue: 7 Pages: 0000-0000
- DOI
  10.1128/iai.00280-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08470, KAKENHI-PROJECT-16K08783
[Journal Article] The bactericidal lectin RegIIIbeta prolongs gut colonization and enteropathy in the streptomycin mouse model for Salmonella diarrhea2017
- Author(s)
  Tsuyoshi Miki, Ryosuke Goto, Mayuka Fujimoto, Nobuhiko Okada, and Wolf-Dietrich Hardt
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 21 Issue: 2 Pages: 195-207
- DOI
  10.1016/j.chom.2016.12.008
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08783
[Journal Article] Inflammatory bactericidal lectin RegIIIβ: Friend or foe for the host?2017
- Author(s)
  Miki Tsuyoshi、Okada Nobuhiko、Hardt Wolf-Dietrich
- Journal Title
  
  Gut Microbes
  
  Volume: 0 Issue: 2 Pages: 1-9
- DOI
  10.1080/19490976.2017.1387344
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08783
[Journal Article] Salmonella Typhimurium PagP- and UgtL-dependent resistance to antimicrobial peptides contributes to the gut colonization2017
- Author(s)
  Goto Ryosuke、Miki Tsuyoshi、Nakamura Nao、Fujimoto Mayuka、Okada Nobuhiko
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 12 Pages: e0190095-e0190095
- DOI
  10.1371/journal.pone.0190095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08783
[Journal Article] Draft Genome Sequence of Chromobacterium haemolyticum Causing Human Bacteremia Infection in Japan2014
- Author(s)
  Miki T, Okada N
- Journal Title
  
  Genome Announcement
  
  Volume: 2 Issue: 6
- DOI
  10.1128/genomea.01047-14
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293106, KAKENHI-PROJECT-25460547
[Journal Article] Functional Characterization of the Type III Secretion ATPase SsaN Encoded by Salmonella Pathogenicity Island 22014
- Author(s)
  Yukie Yoshida, Tsuyoshi Miki, Sayaka Ono, Takeshi Haneda, Masahiro Ito, Nobuhiko Okada
- Journal Title
  
  PLOS ONE
  
  Volume: 9 Issue: 4 Pages: e94347-e94347
- DOI
  10.1371/journal.pone.0094347
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24590534, KAKENHI-PROJECT-25293106, KAKENHI-PROJECT-25460547
[Journal Article] The Chromobacterium type III effector CopE, a guanine nucleotide exchange factor for Racl And Cdc42, is involved in bacterial invasion of epithelial cells and pathogenesis.2011
- Author(s)
  Miki T, Akiba K, Iguchi M, Danbara H, Okada N.
- Journal Title
  
  Mol.Microbiol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] The Chromobacterium type III effector CopE, a guanine nucleotide exchange factor for Rac1 And Cdc42, is involved in bacterial invasion of epithelial cells and pathogenesis2011
- Author(s)
  Miki, T., K. Akiba, M. Iguchi, H. Danbara and N. Okada
- Journal Title
  
  Mol. Microbiol
  
  Volume: 80 Pages: 1186-1203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] The Chromobacterium violaceum type III effector CopE, a guanine nucleotide exchange factor for Rac1 and Cdc42, is involved in bacterial invasion of epithelial cells and pathogenesis2011
- Author(s)
  Miki, T., Akiba, K., Iguchi, M., Danbara, H., Okada, N.
- Journal Title
  
  Molecular Microbiotogy
  
  Volume: (未定印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790414
[Journal Article] The Chromobacterium type III effector CopE, a guanine nucleotide exchange factor for Rac1 And Cdc42, is involved in bacterial invasionof epithelial cells and pathogenesis2011
- Author(s)
  Miki, T., K.Akiba, M.Iguchi, H.Danbara, N.Okada
- Journal Title
  
  Mol.Microbiol.
  
  Volume: 80 Issue: 5 Pages: 1186-1203
- DOI
  10.1111/j.1365-2958.2011.07637.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] Construction and evaluation of Salmonella enterica slyA mutant strain for use in live attenuated oral vaccines2011
- Author(s)
  Haneda T, N. Okada, Y. Kikuchi, M. Takagi, T. Kurotaki, T. Miki, S. Arai and H. Danbara
- Journal Title
  
  Comp. Immunol. Microbiol. Infect. Dis
  
  Volume: 34 Pages: 399-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] Construction and evaluation of Salmonella enterica slyA mutant strain for use in live attenuated oral vaccines2011
- Author(s)
  Haneda T, N.Okada, Y.Kikuchi, M.Takagi, T.Kurotaki, T.Miki, S.Arai, H.Danbara
- Journal Title
  
  Comp.Immunol.Microbiol.Infect.Dis.
  
  Volume: 34 Pages: 399-409
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes.2010
- Author(s)
  Miki T, Iguchi M, Akiba K, Hosono M, Sobue T, Danbara H, Okada N.
- Journal Title
  
  Mol.Microbiol.
  
  Volume: 77 Pages: 855-872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] Comparative proteomic analysis of Salmonella enterica serovar Typhimurium ppGpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages2010
- Author(s)
  Haneda, H., M. Sugimoto, Y. Yoshida-Ohta, Y. Kodera, M. Oh-Ishi, T. Maeda, S. Shimizu-Izumi, T. Miki, Y. Kumagai, H. Danbara, and N. Okada
- Journal Title
  
  BMC Mocrobiol
  
  Volume: 10 Issue: 1 Pages: 324-324
- DOI
  10.1186/1471-2180-10-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] Comparative proteomic analysis of Salmonella enterica serovar Typhimurium pp Gpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages.2010
- Author(s)
  Haneda H, Sugimoto M, Yoshida-Ohta Y, Kodera Y, Oh-Ishi M, Maeda T, Shimizu-Izumi S, Miki T, Kumagai Y, Danbara H, Okada N.
- Journal Title
  
  BMC Mocrobiol.
  
  Volume: 10 Pages: 324-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] Chromobacterium pathogenicity island 1 type III secretion system is a major virulence determinant for Chromobacterium violaceum-induced cell death in hepatocytes2010
- Author(s)
  Miki, T., M. Iguchi, K. Akiba, M. Hosono, T. Sobue, H. Danbara and N. Okada
- Journal Title
  
  Mol. Microbiol
  
  Volume: 77 Pages: 855-872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] Functional characterization of SsaE, a novel chaperone protein of the type III secretionsystem encoded by Salmonella pathogenicity island 22009
- Author(s)
  三木剛志、柴垣芳夫、檀原宏文、岡田信彦
- Journal Title
  
  J.Bacteriol. 191
  
  Pages: 6843-6854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Journal Article] Functional characterization of SsaE, a novel chaperone protein of the type III secretion system encoded by Salmonella pathogenicity island 22009
- Author(s)
  Miki, T., Y. Shibagaki, H. Danbara and N. Okada
- Journal Title
  
  J. Bacteriol
  
  Volume: 191 Pages: 6843-6854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590490
[Presentation] Fatty acid homeostasis tubes flagellar motility, contributing to Salmonella gut colonization2023
- Author(s)
  Tsuyoshi Miki, Yusuke Hoshino, Taro Sakamoto, Naoki Sudo, Masahiro Ito, Takeshi Haneda, Nobuhiko Okada
- Organizer
  日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K07030
[Presentation] RegIIIbeta lectin prolongs the gut colonization and enteropathy inflicted with Salmonella Typhimurium2017
- Author(s)
  Tsuyoshi Miki and Nobuhiko Okada
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター展示棟
- Year and Date
  2017-03-18
- Data Source
  KAKENHI-PROJECT-16K08783
[Presentation] 抗菌レクチンRegIIIbetaの抗菌メカニズム2013
- Author(s)
  三木剛志＆Wolf-Dietrich Hardt
- Organizer
  第7回細菌学若手コロッセウム2013
- Place of Presentation
  広島エアポートホテル（広島県三原市）
- Data Source
  KAKENHI-PROJECT-25460547
[Presentation] Chromobacterium III型分泌機構エフェクターCopEの機能解析2011
- Author(s)
  三木剛志、松本あずさ、岡田信彦
- Organizer
  第14回北里微生物アカデミー
- Place of Presentation
  北里大学相模原キャンパス(相模原市)
- Year and Date
  2011-08-23
- Data Source
  KAKENHI-PROJECT-21590490
[Presentation] Chromobacterium violaceumの病原性発現におけるIII型分泌機構の役割2010
- Author(s)
  三木剛志、岡田信彦、檀原宏文
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21590490
[Presentation] Chromobacterium violaceumの病原性発現におけるIII型分泌機構の役割2010
- Author(s)
  三木剛志、岡田信彦、檀原宏文
- Organizer
  第83回日本細菌学会総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-21590490
[Presentation] Chromobacterium violaceumエフェクター候補因子CV2266の機能解析2009
- Author(s)
  石井真利衣、三木剛志、秋庭きなり、岡田信彦、檀原宏文
- Organizer
  第92回日本細菌学会関東支部総会
- Place of Presentation
  東京医科歯科大学(東京)
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-21590490
[Presentation] Salmonella pathogenicity island 2上にコードされるSsaNの機能解析2009
- Author(s)
  小野紗矢佳、三木剛志、岡田信彦、檀原宏文
- Organizer
  第92回日本細菌学会関東支部総会
- Place of Presentation
  東京
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-21590490
[Presentation] Salmonella pathogenicity island2上にコードされるSsaNの機能解析2009
- Author(s)
  小野紗矢佳、三木剛志、岡田信彦、檀原宏文
- Organizer
  第92回日本細菌学会関東支部総会
- Place of Presentation
  東京医科歯科大学(東京)
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-21590490
[Presentation] Chromobacterium violaceumエフェクター候補因子CV2266の機能解析2009
- Author(s)
  石井真利衣、三木剛志、秋庭きなり、岡田信彦、檀原宏文
- Organizer
  第92回日本細菌学会関東支部総会
- Place of Presentation
  東京
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-21590490

1. OKADA Nobuhiko (80194364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
2. 羽田健

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Miki Tsuyoshi 三木 剛志

MIKI Tsuyoshi 三木 剛志

三木 剛志 ミキ ツヨシ

Research Projects

Research Products

Co-Researchers

病原菌感染におけるREG3の新たな役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of fatty acid metabolism in Salmonella pathogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of the bactericidal lectin RegIIIbeta in Salmonella gut infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of the bactericidal lectin in bacterial enterocolitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペリプラズム酸化還元酵素によるサルモネラ属細菌の病原性発現に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional characterization of type III secretion apparatus STM1410 encoded by Salmonella pathogenicity island 2

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ゲノム情報を利用したサルモネラIII型分泌機構エフェクターの網羅的同定と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 臨床免疫・アレルギー科2017

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Possible link between colonization of the gastrointestinal tract by <i>Citrobacter rodentium</i> in C57BL/6 mice and microbiota composition2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The CpxRA two-component system of adherent and invasive <i>Escherichia coli</i> contributes to epithelial cell invasion and early-stage intestinal fitness in a dysbiotic mouse model mediated by type 1 fimbriae expression2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>uvrY<I> Deletion and Acetate Reduce Gut Colonization of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli by Decreasing Expression of Type 1 Fimbriae2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fatty acid homeostasis tunes flagellar motility by activating phase 2 flagellin expression, contributing to Salmonella gut colonization2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tat-exported peptidoglycan amidase-dependent cell division contributes to Salmonella Typhimurium fitness in the inflamed gut2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Salmonella Typhimurium CpxRA two-component system contributes to gut colonization in Salmonella-induced colitis2018

Author(s)

Miki Tsuyoshi 三木剛志

MIKI Tsuyoshi 三木剛志

三木剛志ミキツヨシ