KASSAI HIDETOSHI 葛西秀俊

… Alternative Names

Researcher Number	40403232
Other IDs
External Links
Affiliation (Current)	2019: 東京大学, 大学院医学系研究科(医学部), 准教授
Affiliation (based on the past Project Information) *help	2016 – 2018: 東京大学, 大学院医学系研究科(医学部), 准教授 2015: 東京大学, 医学(系)研究科(研究院), 准教授 2011 – 2012: 東京大学, 医学(系)研究科(研究院), 助教 2009 – 2012: Kobe University, 大学院・医学系研究科, 助教 2008: Kobe University, 大学院・医学研究科, 助教 2007: Kobe University, Graduate School of Medicine, Assistant Professor 2006: 神戸大学, 大学院医学系研究科, 助手
Review Section/Research Field	Principal Investigator Neuroscience in general / Neuroscience in general / Neurophysiology / General neuroscience / Basic Section 46010:Neuroscience-general-related Except Principal Investigator Neuroscience in general / Neuroscience in general
Keywords	Principal Investigator 遺伝子操作マウス / mTOR / マウス / トランスジェニックマウス / 大脳皮質 / 分子 / 低分子量Gタンパク質 / 神経細胞 / 細胞神経科学 / Rac … More Except Principal Investigator Cdc42 / 脳・神経 / cerebellum / Rho family / 小脳 / Rhoファミリー / シグナル伝達 / knockout mice / cdc42 / Cre / ノックアウトマウス / cerebral cortex / 大脳皮質 / 神経科学 / 遺伝学 / Ella-Cre Less

精神神経疾患における新規mTOR相互作用因子の機能解析Principal InvestigatorOngoing
- Principal Investigator
  
  葛西秀俊
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  The University of Tokyo
Analysis of mTOR signaling in central nervous systemsPrincipal Investigator
- Principal Investigator
  
  Kassai Hidetoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurophysiology / General neuroscience
- Research Institution
  The University of Tokyo
Genetic analysis of physiological function of Rac1 and Cdc42 in dendritic spinesPrincipal Investigator
- Principal Investigator
  
  KASSAI Hidetoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The University of Tokyo
Roles of mTOR in neuronal development, synaptic plasticity and learning and memory
- Principal Investigator
  
  AIBA Atsu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The University of Tokyo
Functional analysis of small G protein Rac1 and Rac3 signalings during corticogenesisPrincipal Investigator
- Principal Investigator
  
  KASSAI Hidetoshi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kobe University
C3毒素発現マウスを用いた小脳における低分子量Gタンパク質Rhoの機能解析Principal Investigator
- Principal Investigator
  
  葛西秀俊
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kobe University
Neuronal development and synaptic plasticity in Cdc42 cenditional knockout mice
- Principal Investigator
  
  AIBA Atsu
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Kobe University

All 2018 2017 2016 2012 2011 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] 動物/疾患モデルの作製技術・病態解析・評価手法、恒常的活性化型mTOR による精神神経疾患モデルマウスの作製2017
- Author(s)
  葛西秀俊・坂井祐介・饗場篤
- Total Pages
  428
- Publisher
  技術情報協会
- ISBN
  9784861046650
- Data Source
  KAKENHI-PROJECT-15K06701
[Book] 細胞工学（ターゲット・オブ・mTOR、mTORシグナルによる脳機能の調節と破綻）2012
- Author(s)
  葛西秀俊
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-23700368
[Book] 「mTORシグナルによる脳機能の調節と破綻」細胞工学2012
- Author(s)
  葛西秀俊,饗場篤
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-22300106
[Book] 「mTORシグナルによる脳機能の調節と破綻」細胞工学2012
- Author(s)
  葛西秀俊,饗場篤
- Publisher
  学研メディカル秀潤社
- Data Source
  KAKENHI-PROJECT-23700368
[Book] Farnesylation versus geranylgeranylation in G-protein-mediated light signaling.2011
- Author(s)
  Hidetoshi Kassai, Yoshitaka Fukada
- Publisher
  The Enzymes
- Data Source
  KAKENHI-PROJECT-23700368
[Book] The Enzymes, Protein Prenylation PART A2011
- Author(s)
  Hidetoshi Kassai
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-23700368
[Journal Article] Oocyte-activating capacity of fresh and frozen-thawed spermatids in the common marmoset (Callithrix jacchus)2018
- Author(s)
  Ogonuki N, Inoue H, Matoba S, Kurotaki YK, Kassai H, Abe Y, Sasaki E, Aiba A, Ogura A
- Journal Title
  
  Mol Reprod Dev.
  
  Volume: -
- DOI
  10.1002/mrd.22971
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112009, KAKENHI-PROJECT-16H06146, KAKENHI-PROJECT-15K06701
[Journal Article] Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.2018
- Author(s)
  Tsuneyama Koichi、Morimoto Yuki、Shimizu Tomo、Jona Masahiro、Kassai Hidetoshi、Nakao Kazuki、Aiba Atsu、Kurano Makoto、Yatomi Yutaka
- Journal Title
  
  Thromb Haemost.
  
  Volume: -
- DOI
  10.1055/s-0038-1641750
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05906, KAKENHI-PROJECT-16H06236, KAKENHI-PROJECT-15K06701
[Journal Article] Use of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus).2017
- Author(s)
  Ueda J, Murata Y, Bundo M, Oh-Nishi A, Kassai H, Ikegame T, Zhao Z, Jinde S, Aiba A, Suhara T, Kasai K, Kato T, Iwamoto K
- Journal Title
  
  Neurosci Res.
  
  Volume: in press Pages: 60-65
- DOI
  10.1016/j.neures.2017.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24116009, KAKENHI-PROJECT-15K06701
[Journal Article] Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways2016
- Author(s)
  Kikuchi I, Takahashi-Kanemitsu A, Sakiyama N, Tang C, Tang PJ, Noda S, Nakao K, Kassai H, Sato T, Aiba A, and Hatakeyama M.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Pages: 12887-12887
- DOI
  10.1038/ncomms12887
- Open Access / Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PLANNED-25115010, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16J02902, KAKENHI-PROJECT-15K18399, KAKENHI-PROJECT-15K06701, KAKENHI-PROJECT-16K15273
[Journal Article] mTORの活性化変異と疾患発生2016
- Author(s)
  葛西秀俊、饗場篤、前田達哉
- Journal Title
  
  結節性硬化症の診断と治療最前線
  
  Volume: - Pages: 46-51
- Data Source
  KAKENHI-PROJECT-15K06701
[Journal Article] Rho GTPase protein Cdc42 is criticak for postnatal cartilage development2016
- Author(s)
  Nagahama R, Yamada A, Tanaka J, Aizawa R, Suzuki D, Kassai H, Yamamoto M, Mishima K, Aiba A, Maki K, Kamijo R.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 470 Pages: 813-817
- DOI
  10.1016/j.bbrc.2016.01.111
- Acknowledgement Compliant / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06701, KAKENHI-PROJECT-15K11051, KAKENHI-PROJECT-15K20368, KAKENHI-PROJECT-15K20627, KAKENHI-PROJECT-15H05016, KAKENHI-PROJECT-26670813, KAKENHI-PROJECT-26870583, KAKENHI-PROJECT-16K20426
[Journal Article] Cdc42 isrequired for chondrogenesis and interdigital programmed cell death during limb development.2012
- Author(s)
  Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamaguchi A, Aiba A, Kamijo R
- Journal Title
  
  Mech. Dev
  
  Volume: 129 Pages: 38-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700368
[Journal Article] Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca^2+ channel in mouse CA1pyramidal cells.2012
- Author(s)
  Kato HK, Kassai H, Watabe AM, Aiba A, Manabe T
- Journal Title
  
  J. Physiol
  
  Volume: 590 Pages: 3019-3034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23700368
[Journal Article] Functional coupling of the metabotropic glutamate receptor, InsP_3 receptor and L-type Ca^2+ channel in mouse CA1 pyramidal cells2012
- Author(s)
  Kato HK, Kassai H, Watabe AM, Aiba A, Manabe T
- Journal Title
  
  Jounal of Physiology
  
  Volume: 590 Pages: 3019-3034
- DOI
  10.1113/jphysiol.2012.232942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300106, KAKENHI-PROJECT-23220008, KAKENHI-PROJECT-23650214, KAKENHI-PROJECT-23700368
[Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development.2012
- Author(s)
  Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamagchi A, Aiba A, Kamijo R
- Journal Title
  
  Mech Dev l2012
  
  Volume: (In press) Pages: 320128-50
- DOI
  10.1016/j.mod.2012.02.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01113, KAKENHI-PROJECT-22249061, KAKENHI-PROJECT-22300106, KAKENHI-PROJECT-22890180, KAKENHI-PROJECT-23390417, KAKENHI-PROJECT-23592748, KAKENHI-PROJECT-23650214, KAKENHI-PROJECT-23659855, KAKENHI-PROJECT-23700368
[Journal Article] Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation.2008
- Author(s)
  Hidetoshi Kassai, Toshio Terashima, Masahiro Fukaya, Kazuki Nakao, Mizuho Sakahara, Masahiko Watanabe, Atsu Aiba
- Journal Title
  
  Eur. J. Neurosci. 28(2)
  
  Pages: 257-67
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700289
[Journal Article] Rac1 in cortical projection neurons is selectively required for midline crossing of commissural axonal formation.2008
- Author(s)
  葛西秀俊
- Journal Title
  
  European Journal of Neuroscience 28
  
  Pages: 257-267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700289
[Journal Article] protein-independent neuromodulatory action of adenosine on metabotropic glutamate signaling in mouse cerebellar Purkinje Cells2007
- Author(s)
  Tabata, T., Kawakami, D., Hashimoto, K., Kassai, H., Yoshida, T., Hashimotodani, Y., Fredholm, B. B., Seikno, Y., Aiba, A., Kano, M. G
- Journal Title
  
  J. Physiol 581-2
  
  Pages: 693-708
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18300106
[Journal Article] 脂質修飾 : 蛋白質の機能制御因子2007
- Author(s)
  葛西秀俊他
- Journal Title
  
  分子細胞治療 6(1)
  
  Pages: 43-50
- Data Source
  KAKENHI-PROJECT-18700318
[Journal Article] 質量分析法による翻訳後修飾の精密解析 : 光シグナル伝達系でのファルネシル化の役割2006
- Author(s)
  葛西秀俊他
- Journal Title
  
  細胞工学 25(6)
  
  Pages: 608-612
- Data Source
  KAKENHI-PROJECT-18700318
[Journal Article] Gタンパク質の選択的ファルネシル化による光シグナル伝達の制御2006
- Author(s)
  葛西秀俊他
- Journal Title
  
  生化学 78(6)
  
  Pages: 533-537
- Data Source
  KAKENHI-PROJECT-18700318
[Presentation] Activation of mTORC1 signaling in cerebellar Purkinje cells causes cell death and hypertrophy of Purkinje cells2017
- Author(s)
  坂井祐介・葛西秀俊・中山寿子・中尾和貴・前田達哉・橋本浩一・狩野方伸・饗場篤
- Organizer
  第40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-15K06701
[Presentation] Activation of mTORC1 signaling in cerebellar Purkinje cells causes cell death and hypertrophy of Purkinje cells2017
- Author(s)
  坂井祐介・葛西秀俊・中山寿子・中尾和貴・前田達哉・橋本浩一・狩野方伸・饗場篤
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K06701
[Presentation] Genetic manipulation of mTORC1 signaling in mouse cerebellar Purkinje cell2016
- Author(s)
  Hidetoshi Kassai, Yusuke Sakai, Hisako Nakayama, Tatsuya Maeda, Kouichi Hashimoto, Masanobu Kano, Atsu Aiba
- Organizer
  46th annual meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06701
[Presentation] Genetic manipulation of mTOR signaling in mouse cerebral cortex2012
- Author(s)
  葛西秀俊
- Organizer
  42nd annual meeting of the Society for Neuroscience
- Place of Presentation
  アメリカ、ニューオーリンズ
- Data Source
  KAKENHI-PROJECT-23700368
[Presentation] Genetic manipulation of mTOR signaling in mouse cerebral cortex2012
- Author(s)
  Hidetoshi Kassai
- Organizer
  42nd annual meeting of the Society forNeuroscience
- Place of Presentation
  New Oleans, USA
- Year and Date
  2012-10-17
- Data Source
  KAKENHI-PROJECT-23700368
[Presentation] 大脳皮質形成におけるmTORシグナリングの機能解析2011
- Author(s)
  葛西秀俊
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川県・パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23700368
[Presentation] 大脳皮質形成におけるmTORシグナリングの機能解析2011
- Author(s)
  葛西秀俊
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜市・パシフィコ横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23700368
[Presentation] プロテオミクス手法を用いた遺伝子改変マウスの脳機能解析2009
- Author(s)
  葛西秀俊
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜市・パシフィコ横浜
- Year and Date
  2009-12-11
- Data Source
  KAKENHI-PROJECT-20700289
[Presentation] 小脳プルキンエ細胞におけるmGluR1-Homer複合体の生理機能解析2009
- Author(s)
  葛西秀俊・渡久川兼誉・橋本浩一・岡村千絵子・中尾和貴・狩野方伸・饗場篤
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜市・パシフィコ横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20700289
[Presentation] Small G protein Rac1 is selectively required for the formation of commissural axons in the cerebral cortex2008
- Author(s)
  Hidetoshi Kassai, Toshio Terashima, Masahiro Fukaya, Kazuki Nakao, Mizuho Sakahara, Masahiko Watanabe, Atsu Aiba
- Organizer
  37th annual meeting of the Society for Neuroscience
- Place of Presentation
  アメリカ合衆国・ワシントンD.C.
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-20700289
[Presentation] 大脳皮質の交連線維形成におけるRac1の役割2008
- Author(s)
  葛西秀俊
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Year and Date
  2008-07-09
- Data Source
  KAKENHI-PROJECT-20700289
[Presentation] Small G protein Rac1 is selectively required for the formation of commissural axons in the cerebral cortex2008
- Author(s)
  葛西秀俊
- Organizer
  37th annual meeting of the Society for Neuroscience
- Place of Presentation
  Washington DC, USA
- Year and Date
  2008-11-16
- Data Source
  KAKENHI-PROJECT-20700289
[Presentation] 大脳皮質の交連線維形成におけるRac1の役割2008
- Author(s)
  葛西秀俊・寺島俊雄・深谷昌弘・中尾和貴・坂原瑞穂・渡辺雅彦・饗場篤
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京・東京国際フォーラム
- Year and Date
  2008-07-09
- Data Source
  KAKENHI-PROJECT-20700289
[Presentation] 大脳皮質および海馬形成におけるRac1の機能解析2007
- Author(s)
  葛西秀俊
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-18700318

1. AIBA Atsu (20271116)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. HARADA Takeshi (30362768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. MATOBA Shogo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. Sato Hirofumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. MURATA Yui

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. IKEGAME Tempei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. UEDA Junko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KURANO Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. SUZUKI Dai

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 小倉淳郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 佐々木裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 畠山昌則

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 高橋昌史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 岩本和也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 文東美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 有田誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 矢富裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 田中準一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 相澤怜

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 田中栄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 山田篤

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 上條竜太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. 飯村忠浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 山口朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KASSAI HIDETOSHI 葛西 秀俊

Kassai Hidetoshi 葛西 秀俊

KASSAI Hidetoshi 葛西 秀俊

Research Projects

Research Products

Co-Researchers

精神神経疾患における新規mTOR相互作用因子の機能解析Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of mTOR signaling in central nervous systemsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic analysis of physiological function of Rac1 and Cdc42 in dendritic spinesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of mTOR in neuronal development, synaptic plasticity and learning and memory

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of small G protein Rac1 and Rac3 signalings during corticogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

C3毒素発現マウスを用いた小脳における低分子量Gタンパク質Rhoの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuronal development and synaptic plasticity in Cdc42 cenditional knockout mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 動物/疾患モデルの作製技術・病態解析・評価手法、恒常的活性化型mTOR による精神神経疾患モデルマウスの作製2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 細胞工学（ターゲット・オブ・mTOR、mTORシグナルによる脳機能の調節と破綻）2012

Author(s)

Publisher

Data Source

[Book] 「mTORシグナルによる脳機能の調節と破綻」細胞工学2012

Author(s)

Publisher

Data Source

[Book] 「mTORシグナルによる脳機能の調節と破綻」細胞工学2012

Author(s)

Publisher

Data Source

[Book] Farnesylation versus geranylgeranylation in G-protein-mediated light signaling.2011

Author(s)

Publisher

Data Source

[Book] The Enzymes, Protein Prenylation PART A2011

Author(s)

Publisher

Data Source

[Journal Article] Oocyte-activating capacity of fresh and frozen-thawed spermatids in the common marmoset (Callithrix jacchus)2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury.2018

KASSAI HIDETOSHI 葛西秀俊

Kassai Hidetoshi 葛西秀俊

KASSAI Hidetoshi 葛西秀俊