Imamura Michio 今村道雄

… Alternative Names

IMAMURA Michio 今村道雄

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Researcher Number	40403513
Affiliation (based on the past Project Information) *help	2022: 広島大学, 病院(医), 講師 2016 – 2019: 広島大学, 病院(医), 講師 2015: 広島大学, 大学病院, 講師 2014: 広島大学, 大学病院, 病院助教 2011 – 2012: 広島大学, 病院, 病院助教 2010: 広島大学, 病院, 助教
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator ヒト肝細胞キメラマウス / C型慢性肝炎 / ゲノム編集 / 遺伝子編集 / PNPLA3 / 非アルコール性脂肪肝炎 / 肝臓学 / B型肝炎ウイルス / 末梢血単核球 / ヒト肝細胞移植マウス … More / cccDNA / B型肝炎 / deep sequence / 耐性変異 / NS5A阻害薬 / 薬剤耐性変異 / DAA / IL28B / ISDR / HCV Core変異 / IL38B遺伝子多型 / インターフェロン Less

ゲノム編集による非アルコール性脂肪肝炎の新規治療法開発Principal Investigator
- Principal Investigator
  
  今村道雄
- Project Period (FY)
  2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
Elimination of cccDNA by genome editing by using HBV-infected micePrincipal Investigator
- Principal Investigator
  
  Imamura Michio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University
Development of therapies for DAA-resistant HCVPrincipal Investigator
- Principal Investigator
  
  Imamura Michio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University
Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis C virusPrincipal Investigator
- Principal Investigator
  
  IMAMURA Michio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University

All 2020 2018 2017 2016 2015 2014 2012 2011 2010

All Journal Article Presentation

[Journal Article] Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.2020
- Author(s)
  Cheng X, Uchida T, Xia Y, Umarova R, Liu CJ, Chen PJ, Gaggar A, Suri V, Mucke MM, Vermehren J, Zeuzem S, Teraoka Y, Osawa M, Aikata H, Tsuji K, Mori N, Hige S, Karino Y, Imamura M, Chayama K, Liang TJ.
- Journal Title
  
  J Clin Invest.
  
  Volume: - Issue: 6 Pages: 3205-3220
- DOI
  10.1172/jci135616
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09426, KAKENHI-PROJECT-17K09427
[Journal Article] Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics2018
- Author(s)
  Ishida Y, Chung TL, Imamura M, Hiraga N, Sen S, Yokomichi H, Tateno C, Canini L, Perelson AS, Uprichard SL, Dahari H, Chayama K
- Journal Title
  
  Hepatology
  
  Volume: 68 Issue: 2 Pages: 473-484
- DOI
  10.1002/hep.29891
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09427
[Journal Article] Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology.2017
- Author(s)
  Uchida T, Imamura M, Kan H, Hiraga N, Hayes CN, Tsuge M, Abe-Chayama H, Aikata H, Makokha GN, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K.
- Journal Title
  
  J Gen Virol.
  
  Volume: 印刷中 Issue: 5 Pages: 1040-1047
- DOI
  10.1099/jgv.0.000726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-17K09427, KAKENHI-PROJECT-15K09002
[Journal Article] Persistent loss of HBV markers in serum without cellular immunity by combination of PEG-IFN plus ETV therapy in humanized mice2017
- Author(s)
  Uchida T, Imamura M, Hayes CN, Hiraga N, Kan H, Tsuge M, Abe-Chayama H, Zhang Y, Makokha GN, Aikata H, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 61 Issue: 9
- DOI
  10.1128/aac.00725-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09427, KAKENHI-PROJECT-15K09002, KAKENHI-PROJECT-15K09003, KAKENHI-PROJECT-16K19346
[Journal Article] Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice2016
- Author(s)
  Kan H, Hiraga N, Imamura M, Hayes CN, Uchida T, Miyaki E, Tsuge M, Abe H, Aikata H, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K.
- Journal Title
  
  Antiviral Therapy
  
  Volume: 21 Issue: 4 Pages: 307-15
- DOI
  10.3851/imp3009
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461008
[Journal Article] Protease inhibitor resistance remains even after mutant strains become undetectable using deep sequencing2016
- Author(s)
  Kan H, Imamura M, Uchida T, Hiraga N, Hayes CN, Tsuge M, Abe H, Aikata H, Makokha GN, Chowdhury S, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K.
- Journal Title
  
  Journal of Infectious Disease
  
  Volume: 214 Issue: 11 Pages: 1687-1694
- DOI
  10.1093/infdis/jiw437
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-15K09004
[Journal Article] Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice.2016
- Author(s)
  Uchida T, Hiraga N, Imamura M, Yoshimi S, Kan H, Miyaki E, Tsuge M, Abe H, Hayes CN, Aikata H, Ishida Y, Tateno C, Ellis JD, Chayama K.
- Journal Title
  
  Virus Reserch
  
  Volume: 213 Pages: 62-8
- DOI
  10.1016/j.virusres.2015.11.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461008
[Journal Article] Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy.2015
- Author(s)
  Yoshimi S, Imamura M, Murakami E, Hiraga N, Tsuge M, Kawakami Y, Aikata H, Abe H, Hayes CN, Sasaki T, Ochi H, Chayama K.
- Journal Title
  
  J Med Virol.
  
  Volume: 87 Issue: 11 Pages: 1913-1920
- DOI
  10.1002/jmv.24255
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26461008
[Journal Article] Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin2014
- Author(s)
  Murakami, E. Imamura, M. Hayes, C. N. Abe, H. Hiraga, N. Honda, Y. Ono, A. Kosaka, K. Kawaoka, T. Tsuge, M. Aikata, H. Takahashi, S. Miki, D. Ochi, H. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Chayama, K.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 58 Issue: 4 Pages: 2105-2112
- DOI
  10.1128/aac.02068-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
[Journal Article] Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1.2014
- Author(s)
  Kosaka K, Imamura M, Hayes CN, Abe H, Hiraga N, Yoshimi S, Murakami E, Kawaoka T, Tsuge M, Aikata H, Miki D, Ochi H, Matsui H, Kanai A, Inaba T, Chayama K.
- Journal Title
  
  J Viral Hepat.
  
  Volume: 22 Issue: 2 Pages: 158-165
- DOI
  10.1111/jvh.12271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-26860536
[Journal Article] Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication2012
- Author(s)
  Chayama K, Hayes CN, Imamura M
- Journal Title
  
  Hepatol Res
  
  Volume: 42(9) Pages: 841-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590737
[Journal Article] Genetics of IL28B and HCV-response to infection and treatment2012
- Author(s)
  Hayes CN, Imamura M, Aikata H, Chayama K
- Journal Title
  
  Nat Rev Gastroenterol Hepatol
  
  Volume: 9(7) Pages: 406-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590737
[Journal Article] Predictive value of the IL28B polymorphism on the effect of interferon therapy in chronic hepatitis C patients with genotypes 2a and 2b.2011
- Author(s)
  Kawaoka T, Hayes CN, Ohishi W, Ochi H Maekawa T, Abe H, Tsuge M, Mitsui F Hiraga N, Imamura M, Takahashi S, Kubo M, Tsunoda T, Nakamura Y, Kumada H, Chayama K.
- Journal Title
  
  J Hepatol
  
  Volume: 54 Pages: 408-414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590737
[Journal Article] Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis C virus2011
- Author(s)
  Hiraga N, Abe H, Imamura M, Tsuge M, Takahashi S, Hayes CN, Ochi H, Tateno C, Yoshizato K, Nakamura Y, Kamatani N, Chayama K
- Journal Title
  
  Hepatology
  
  Volume: 54(3) Pages: 764-771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590737
[Journal Article] HCV substitutions and IL28B polymorphisms on outcome of peg-interferon plus ribavirin combination therapy.2011
- Author(s)
  Hayes CN, Kobayashi M, Akuta N, Suzuki F, Kumada H, Abe H, Miki D, Imamura M, Ochi H, Kamatani N, Nakamura Y, Chayama K.
- Journal Title
  
  Gut
  
  Volume: 60 Pages: 261-267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590737
[Journal Article] Rapidemergence of telaprevir resistanthepatitis C virus strain from wildtypeclone in vivo2011
- Author(s)
  Hiraga N, Imamura M, Abe H, Hayes CN, Kono T, Onishi M, Tsuge M, TakahashiS, Ochi H, Iwao E, Kamiya N, Yamada I, Tateno C, Yoshizato K, Matsui H, KanaiA, Inaba T, Tanaka S, Chayama K
- Journal Title
  
  Hepatology
  
  Volume: 54 Issue: 3 Pages: 781-788
- DOI
  10.1002/hep.24460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PLANNED-22118005, KAKENHI-PROJECT-22590737, KAKENHI-PROJECT-22659147, KAKENHI-PROJECT-22659181, KAKENHI-PROJECT-22790646, KAKENHI-PROJECT-22790912, KAKENHI-PROJECT-23390253
[Journal Article] Elimination of Hepatitis C Virus by Short Term NS3-4A and NS5B Inhibitor Combination Therapy in Human Hepatocyte Chimeric Mice2011
- Author(s)
  Ohara E, Hiraga N, Imamura M, et al
- Journal Title
  
  Journal of Hepatology
  
  Volume: 54(5) Issue: 5 Pages: 872-878
- DOI
  10.1016/j.jhep.2010.09.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590737
[Journal Article] Inverse association of IL28B genotype and liver mRNA expression of genes promoting or suppressing antiviral state2011
- Author(s)
  Abe H, Hayes CN, Ochi H, Tsuge M, Miki D, Hiraga N, Imamura M, Takahashi S, Kubo M, Nakamura Y, Kamatani N, Chayama K
- Journal Title
  
  J Med Virol
  
  Volume: 83(9) Pages: 1597-607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590737
[Journal Article] ME3738 enhances the effect of interferon andinhibits hepatitis C virusreplication both in vitro and in vivo2011
- Author(s)
  Abe H, Imamura M, Hiraga N, Tsuge M, Mitsui F, Kawaoka T, Takahashi S, OchiH, Maekawa T, Hayes CN, Tateno C, Yoshizato K, Murakami S, Yamashita N, Matsuhira T, Asai K, Chayama K
- Journal Title
  
  J Hepatol
  
  Volume: 55 Issue: 1 Pages: 11-18
- DOI
  10.1016/j.jhep.2010.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390229, KAKENHI-PROJECT-22590737, KAKENHI-PROJECT-22659147
[Journal Article] Common variation of IL28 affects gamma-GTP levels and inflammation of the liver in chronically infected hepatitis C virus patients.2010
- Author(s)
  Abe H, Ochi H, Maekawa T, Hayes CN, Tsage M, Miki D, Mitsui F, Hiraga N, Imamura M, Takahashi S, Ohishi W, Arihiro K, Kubo M, Nakamura Y, Chayama K.
- Journal Title
  
  J Hepatol
  
  Volume: 53 Pages: 439-443
- NAID
  120002577227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] ヒト肝細胞キメラマウスを用いた肝内cccDNA制御による抗HBV療法2017
- Author(s)
  内田宅郎、今村道雄、茶山一彰
- Organizer
  第53回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-17K09427
[Presentation] Persistent loss of HBV markers in serum without cellular immunity by combination of PEG-IFN plus ETV therapy in humanized mice2017
- Author(s)
  Takuro Uchida, Michio Imamura, Nelson C Hayes, Nobuhiko Hiraga, Masataka Tsuge, Hiromi Abe-Chayama, Grace Naswa Makokha, Yuji Ishida, Chise Tateno, Kazuaki Chayama
- Organizer
  AASLD The liver meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09427
[Presentation] 野生型および耐性型C型慢性肝炎に対するダクラタスビル＋アスナプレビル療法の治療効果2016
- Author(s)
  今村道雄，辻　恵二，茶山一彰
- Organizer
  第102回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-26461008
[Presentation] C型慢性肝炎患者において，NS3/4Aプロテアーゼ阻害薬治療failureに出現したNS3-D168変異はdeep sequenceにより検出されなくなっても残存する2016
- Author(s)
  今村道雄，平賀伸彦，菅　宏美，茶山一彰．
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-26461008
[Presentation] C型慢性肝炎患者において，NS3/4Aプロテアーゼ阻害薬治療failureに出現したNS3-D168変異はdeep sequenceにより検出されなくなっても残存する2016
- Author(s)
  今村道雄，平賀伸彦，菅　宏美，茶山一彰
- Organizer
  第26回抗ウイルス療法研究会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-26461008
[Presentation] Protease inhibitor resistance remains even after mutant strains become undetectable by deep sequencing2016
- Author(s)
  Michio Imamura, Hiromi Kan, Takuro Uchida, Masataka Tsuge, Hiromi Abe, Hiroshi Aikata, Nelson Hayes and Kazuaki Chayama.
- Organizer
  HCV 2016
- Place of Presentation
  Kyoto
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461008
[Presentation] C型慢性肝炎に対するプロテアーゼ阻害剤＋NS5A阻害剤併用療法の治療効果2015
- Author(s)
  今村道雄，川上由育，茶山一彰
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461008
[Presentation] C型慢性肝炎患者におけるDAA耐性株の検討-DAA併用療法を見据えて-2014
- Author(s)
  今村道雄
- Organizer
  第100回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26461008
[Presentation] C型慢性肝炎に対するプロテアーゼ阻害剤＋NS5A阻害剤併用療法の治療効果2014
- Author(s)
  今村道雄
- Organizer
  第18回日本肝臓病学会大会
- Place of Presentation
  神戸
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26461008
[Presentation] C型慢性肝炎に対するプロテアーゼ阻害剤＋NS5A阻害剤併用療法の治療効果および耐性株の検討2014
- Author(s)
  今村道雄
- Organizer
  第59回日本肝臓病学会総会
- Place of Presentation
  東京
- Year and Date
  2014-05-25
- Data Source
  KAKENHI-PROJECT-26461008
[Presentation] IL28B，ITPA遺伝子多型およびウイルス変異からみたC型肝炎の治療方針2012
- Author(s)
  今村道雄
- Organizer
  第48回日本肝臓学会総会
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] C型肝炎ウイルスの感染およびIFN治療におけるIL28B遺伝子多型の影響2012
- Author(s)
  今村道雄,阿部弘美,平賀伸彦,越智秀典,茶山一彰
- Organizer
  第77回インターフェロンサイトカイン学会
- Place of Presentation
  神戸
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] Deep sequencing analysis of hepatitis C virus quasipiecies in patients treated with telaprevir in combination with peginterferon and ribavirin2012
- Author(s)
  Michio Imamura
- Organizer
  The 10th JSH Single Topic Conference
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] C型慢性肝炎に対するこれまでの成績からみた今後の治療方針2011
- Author(s)
  今村道雄
- Organizer
  第47回日本肝臓病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] Impact of Viral Amino Acid Substitutions and Host IL28B polymorphism on Replication and Susceptibility to Interferon of Hepatitis C Virus2011
- Author(s)
  Michio Imamura, Hiromi Abe, Nobuhiko Hiraga, Masataka Tsuge, Shoicih Takahashi, C. Nelson Hayes, Hidenori Ochi, Chise Tateno, Katsutoshi Yoshizato, Kazauaki Chayama
- Organizer
  The 62th Annual Meeting of the American Association for the Study of Liver Diseases.
- Place of Presentation
  San Francisco
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] C型慢性肝炎に対するIFNの治療成績の変遷およびIFN製剤を使用しない新規治療法の可能性2011
- Author(s)
  今村道雄
- Organizer
  第97回日本消化器病学会総会
- Place of Presentation
  東京
- Year and Date
  2011-05-13
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] Impact of Viral Amino Acid Substitutions and Host IL28B polymorphism on Replication and Susceptibility to Interferon of Hepatitis C Virus2011
- Author(s)
  Michio Imamura, et al
- Organizer
  12th AASLD
- Place of Presentation
  San Francisco, USA
- Year and Date
  2011-11-04
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] 宿主およびウイルス因子からみた1b高ウイルス量C型慢性肝炎に対する治療方針2011
- Author(s)
  今村道雄
- Organizer
  第15回日本肝臓病学会大会
- Place of Presentation
  福岡
- Year and Date
  2011-10-21
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] The influences of viral mutations on HCV infectivity, replication ability and the susceptibility to interferon in human hepatocyte chimeric mice2010
- Author(s)
  Michio Imamura
- Organizer
  The 7th APASL Single Topic Conference
- Place of Presentation
  Makuhari, Japan
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] C型慢性肝炎に対するインターフェロン治療におけるIL28B 多型とCore領域変異の影響2010
- Author(s)
  今村道雄,越智秀典,茶山一彰.
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] HCV感染マウスを用いたNS3/4A protease阻害剤およびNS5B polymerase阻害剤併用療法の有用性の検討2010
- Author(s)
  今村道雄
- Organizer
  第14回日本肝臓病学会大会
- Place of Presentation
  横浜
- Year and Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] C型慢性肝炎に対するインターフェロン治療におけるIL28B多型とCore領域変異の影響2010
- Author(s)
  今村道雄
- Organizer
  第96回日本消化器病学会総会
- Place of Presentation
  新潟
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] The influences of viral mutations on HCV infectivity, replication ability and the susceptibility to interferon in human hepatocyte chimeric mice.2010
- Author(s)
  Michio Imamura, Nobuhiko Hiraga, Masataka Tsuge, Shoichi Takahashi, Hiromi Abe, C. Nelson Hayes, Hidenori Ochi and Kazuaki Chayama
- Organizer
  The 7th APASL Single Topic Conference
- Place of Presentation
  Chiba
- Year and Date
  2010-12-17
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] C型慢性肝炎患者におけるIL28B 多型とウイルス側および宿主側因子との関連2010
- Author(s)
  今村道雄,越智秀典,茶山一彰
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Year and Date
  2010-06-27
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] C型慢性肝炎患者におけるIL28B多型とウイルス側および宿主側因子との関連2010
- Author(s)
  今村道雄
- Organizer
  第47回日本肝臓病学会総会
- Place of Presentation
  山形
- Year and Date
  2010-06-27
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] IL-28B predicts response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b2010
- Author(s)
  Michio Imamura, Hidenori Ochi, Hiromi Abe, Tomokazu Kawaoka, Yoshimasa Hashimoto, Shoichi Takahashi, C. Nelson Hayes, Kazuaki Chayama
- Organizer
  HCV 2010
- Place of Presentation
  Yokohama
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-22590737
[Presentation] IL-28B predicts response to peginterferon-alfa-2b plus ribavirin therapy in Japanese patients infected with hepatitis C virus genotype 1b2010
- Author(s)
  Michio Imamura
- Organizer
  HCV 2010
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2010-09-13
- Data Source
  KAKENHI-PROJECT-22590737

1. Nobuhiko Hiraga

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. Keiichi Kosaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Kan Hiromi

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. Takuro Uchida

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ABE Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
6. 茶山一彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Imamura Michio 今村 道雄

IMAMURA Michio 今村 道雄

Research Projects

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ゲノム編集による非アルコール性脂肪肝炎の新規治療法開発Principal Investigator

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Elimination of cccDNA by genome editing by using HBV-infected micePrincipal Investigator

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Development of therapies for DAA-resistant HCVPrincipal Investigator

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Impact of viral amino acid substitutions and host IL28B polymorphism on replication and susceptibility to interferon of hepatitis C virusPrincipal Investigator

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[Journal Article] Diminished hepatic IFN response following HCV clearance triggers HBV reactivation in coinfection.2020

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[Journal Article] Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics2018

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[Journal Article] Usefulness of humanized cDNA-uPA/SCID mice for the study of hepatitis B virus and hepatitis C virus virology.2017

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[Journal Article] Persistent loss of HBV markers in serum without cellular immunity by combination of PEG-IFN plus ETV therapy in humanized mice2017

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[Journal Article] Combination therapies with daclatasvir and asunaprevir on NS3-D168 mutated HCV in human hepatocyte chimeric mice2016

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[Journal Article] Protease inhibitor resistance remains even after mutant strains become undetectable using deep sequencing2016

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[Journal Article] Elimination of HCV via a non-ISG-mediated mechanism by vaniprevir andBMS-788329 combination therapy in human hepatocyte chimeric mice.2016

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[Journal Article] Long term persistence of NS5A inhibitor-resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy.2015

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[Journal Article] Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin2014

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[Journal Article] Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1.2014

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[Journal Article] Impact of interleukin-28B genotype on in vitro and in vivo systems of hepatitis C virus replication2012

Imamura Michio 今村道雄

IMAMURA Michio 今村道雄