Fuchikami Manabu 淵上学

Researcher Number	40403571
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(医), 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 広島大学, 医系科学研究科(医), 講師 2018 – 2020: 広島大学, 病院(医), 講師 2017: 広島大学, 医歯薬保健学研究科(医), 助教 2017: 広島大学, 学内共同利用施設等, 助教 2016: 広島大学, 医歯薬保健学研究院(医), 助教 … More 2015: 広島大学, その他の研究科, 助教 2015: 広島大学, 医歯薬保健学研究院, 助教 2015: 広島大学, 大学病院, 助教 2015: 広島大学, 大学院医歯薬保健学研究院, 助教 2014: 広島大学, 大学病院, 病院助教 Less
Review Section/Research Field	Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science Except Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science / General pharmacology / Hygiene and public health
Keywords	Principal Investigator PTSDの新規治療法 / 忌避学習 / 異常神経活動 / 腹側淡蒼球 / うつ病 / 不適切な養育 / 神経活動操作 / グルココルチコイド / PTSD / PTSDの異常な神経回路 … More / PTSDの予防法 / PTSDの発症機序 / PTSDの病態 / 脳由来神経栄養因子 / 心的外傷後ストレス障害 … More Except Principal Investigator うつ病 / BDNF / 神経回路 / 脳神経疾患 / Depression / DNAメチル化 / 神経活動操作 / 神経回路異常 / アンへドニア / 動物モデル研究 / 脳機能画像研究 / 身体症状 / fear extinction / RNA methylation / 恐怖記憶の消去 / ALKBH5 / FTO / METTL / N6-methyladenosine / Single prolonged stress / 消去障害 / 恐怖記憶 / PTSD / RNAメチル化 / うつ病モデルラット / fMRI / 幼少期ストレス / Dnmt / Genome editing / Methylation / Dnmt3a / メチル化 / DNMT3a / Tet1 / DNA methylation / 脳由来神経栄養因子(BDNF) / ケミカルシャペロン / ERストレス / 薬物検索 / 治療薬検索 / シグナル伝達 / 神経科学 / 薬理学 / プロポフォール / 膜輸送 / 小胞体ストレス / セロトニントランスポーター / 前頭前野 / リアルタイムfMRI / 治療薬反応性 / Copy Number Variant / リチウム / Bipolar Disorder / Copy Number Variation / 双極性障害 / Biomarker / CNV / Lithium / GSK3beta / Bipolar disorder / DSM-IV / DNAメチル化障害 / DSM-Ⅳ / 縦断研究 / SCID / 高齢者 / メチル化障害 / 小うつ病性障害 / 大うつ病性障害 / 疫学 / エピジェネティクス Less

器質的な異常を認めない非特異的な身体症状のマクロおよびミクロ神経回路病態の解明
- Principal Investigator
  
  岡田剛
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hiroshima University
アンヘドニアのマクロおよびミクロ神経回路病態の解明
- Principal Investigator
  
  岡本泰昌
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hiroshima University
腹側淡蒼球からみた適切な養育機会の欠損を経たうつ病の病態と治療法・予防法の研究Principal Investigator
- Principal Investigator
  
  淵上学
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hiroshima University
Elucidation of the involvement of RNA methylation in impairment of fear memory extinction in PTSD and development of a new therapy
- Principal Investigator
  
  森信繁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hiroshima International University
  Kibi International University
The development of the neural circuits based treatment and prevention of major depression in patients having a history of childhood maltreatment.
- Principal Investigator
  
  Yasumasa Okamoto
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hiroshima University
The development of the novel strategy for the prevention of PTSD, and of the novel treatment using neuromodulation.Principal Investigator
- Principal Investigator
  
  Fuchikami Manabu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Hiroshima University
Development of newer animal model, biomarker, and treatment of depression by regulation of BDNFgene methylation using genome editing
- Principal Investigator
  
  Morinobu Shigeru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Kibi International University
Screening and application of drugs that facilitate membrane trafficking in order to overcome ER stress-related diseases
- Principal Investigator
  
  Sakai Norio
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Hiroshima University
A longitudinal study of epigenetic epidemiology for the primary and secondary prevention of elderly depression
- Principal Investigator
  
  IHARA Kazushige
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene and public health
- Research Institution
  Toho University
Development of the therapeutic biomarker in bipolar disorder using CNV and methylation of target genes of mood stabilizers
- Principal Investigator
  
  Morinobu Shigeru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Kibi International University
  Kochi University
Basic research on elucidation of neurocircuit pathology of depression and its remodeling mechanism
- Principal Investigator
  
  Yamawaki Shigeto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Hiroshima University
The therapeutic potential of BDNF and epigenetic changes in the animal model of PTSD.Principal Investigator
- Principal Investigator
  
  Fuchikami Manabu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hiroshima University

All 2024 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Long-term mental health and resilience of the first responders in Japanese ground self-defense forces engaging body recovery after the great east Japan earthquake2024
- Author(s)
  Maeno Yoshikazu、Fuchikami Manabu、Fujimaki Koichiro、Liberzon Israel、Morinobu Shigeru
- Journal Title
  
  Journal of Psychiatric Research
  
  Volume: 173 Pages: 381-386
- DOI
  10.1016/j.jpsychires.2024.03.031
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07568
[Journal Article] Neonatal Isolation Increases the Susceptibility to Learned Helplessness through the Aberrant Neuronal Activity in the Ventral Pallidum of Rats2024
- Author(s)
  Kobayashi Hironori、Fuchikami Manabu、Oga Kenichi、Miyagi Tatsuhiro、Fujita Sho、Fujita Satoshi、Okada Satoshi、Okamoto Yasumasa、Morinobu Shigeru
- Journal Title
  
  Clinical Psychopharmacology and Neuroscience
  
  Volume: 22 Issue: 2 Pages: 354-363
- DOI
  10.9758/cpn.23.1140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07568
[Journal Article] Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD2021
- Author(s)
  Omura Jun、Fuchikami Manabu、Araki Motoaki、Miyagi Tatsuhiro、Okamoto Yasumasa、Morinobu Shigeru
- Journal Title
  
  Progress in Neuro-Psychopharmacology and Biological Psychiatry
  
  Volume: 108 Pages: 110090-110090
- DOI
  10.1016/j.pnpbp.2020.110090
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07562, KAKENHI-PROJECT-18K07575
[Journal Article] Alterations in DNA methylation rates of brain-derived neurotrophic factor in patients with schizophrenia2021
- Author(s)
  Nojima S, Fuchikami M, Kataoka T, Araki M, Omura J, Miyagi T, Okamoto Y, Hishimoto A, Morinobu S
- Journal Title
  
  The European Journal of Psychiatry
  
  Volume: 35 Issue: 2 Pages: 67-74
- DOI
  10.1016/j.ejpsy.2020.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07575
[Journal Article] The role of glucocorticoid receptors in the induction and prevention of hippocampal abnormalities in an animal model of posttraumtic stress disorder2020
- Author(s)
  Araki M, Fuchikami M, Omura J, Miyagi T, Nagashima N, Okamoto Y, Morinobu S
- Journal Title
  
  Psychopharmacology
  
  Volume: in press Issue: 7 Pages: 2125-2137
- DOI
  10.1007/s00213-020-05523-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07575, KAKENHI-PROJECT-18K07562
[Journal Article] Combined brain-derived neurotrophic factor with extinction training alleviate impaired fear extinction in an animal model of post-traumatic stress disorder.2018
- Author(s)
  Kataoka T, Fuchikami M, Nojima S, Nagashima N, Araki M, Omura J, Miyagi T, Okamoto Y, Morinobu S
- Journal Title
  
  Genes Brain & Behavior
  
  Volume: e12520 Issue: 7 Pages: 1-10
- DOI
  10.1111/gbb.12520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07575
[Journal Article] The influence of aging on the methylation status of brain-derived neurotrophic factor gene in blood.2018
- Author(s)
  K. Ihara, M. Fuchikami, M. Hashizume, S. Okada, H. Kawai, S. Obuchi, H. Hirano, Y. Fujiwara, M. Hachisu, H. Kim, S. Morinobu
- Journal Title
  
  International Journal of Geriatric Psychiatry
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08824
[Journal Article] BDNF遺伝子のDNAメチル化を指標としたうつ病診療2016
- Author(s)
  淵上学、森信繁
- Journal Title
  
  Depression Frontier
  
  Volume: 2 Pages: 68-76
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09810
[Journal Article] Blood Diagnostic Biomarkers for Major Depressive Disorder using Multiplex DNA Methylation Profiles: Discovery and Validation.2015
- Author(s)
  Shusuke Numata, Kazuo Ishii, Atsushi Tajima, Jun-Ichi Iga, Makoto Kinoshita, Shinya Watanabe, Hidehiro Umehara, Manabu Fuchikami, Satoshi Okada, Shuken Boku, Akitoyo Hishimoto, Shinji Shimodera, Issei Imoto, Shigeru Morinobu, Tetsuro Ohmori
- Journal Title
  
  Epigenetics
  
  Volume: 10(2) Issue: 2 Pages: 135-141
- DOI
  10.1080/15592294.2014.1003743
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26330325, KAKENHI-PROJECT-26461718, KAKENHI-PROJECT-26461719, KAKENHI-PROJECT-26461720, KAKENHI-PROJECT-15K09810, KAKENHI-PROJECT-26461768
[Journal Article] The potential use of histone deacetylase inhibitors in the treatment of depression2015
- Author(s)
  Fuchikami M, Morinobu S, et al.
- Journal Title
  
  Progress in Neuro-Psychopharmacology & Biological Psychiatry
  
  Volume: 62 Pages: 00059-7
- DOI
  10.1016/j.pnpbp.2015.03.010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25116518, KAKENHI-PROJECT-25861036, KAKENHI-PROJECT-15K09810, KAKENHI-PROJECT-15K19731
[Presentation] 適切な養育機会の欠損を経て発症するうつ病の腹側淡蒼球の神経活動異常とその予防法の研究2022
- Author(s)
  小林弘典, 淵上学, 藤田聡, 藤田翔, 大賀健市, 宮城達博, 森信繁
- Organizer
  BPCNPNPPP4学会合同年会
- Data Source
  KAKENHI-PROJECT-20H03603
[Presentation] 新たなうつ病の病態仮説<Imbalance of excitation-inhibition within the PFC>2019
- Author(s)
  森信　繁、淵上　学
- Organizer
  第38回躁うつ病の薬理・生化学的研究懇話会
- Data Source
  KAKENHI-PROJECT-18K07575
[Presentation] Chemogenetic activation of medial prefrontal cortex excitatory neurons alleviated the impaired fear extinction of an animal model of PTSD.2018
- Author(s)
  Jun Omura, Manabu Fuchikami, Motoaki Araki, Tatsuhiro Miyagi, Sigeru Morinobu, Yasumasa Okamoto
- Organizer
  Society for Neuroscience 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07562
[Presentation] The role of glucocorticoid receptor in the induction and the prevention of the hippocampal abnormalities in an animal model of PTSD2018
- Author(s)
  Motoaki Araki, Manabu Fuchikami, Jun Omura, Tatsuhiro Miyagi, Nobuyuki Nagashima, Shigeru Morinobu, Yasumasa Okamoto
- Organizer
  第40回日本生物学的精神医学会・第61回日本神経化学会大会合同年会
- Data Source
  KAKENHI-PROJECT-18K07562
[Presentation] Chemogenetic activation of medial prefrontal cortex excitatory neurons alleviated the impaired fear extinction of an animal model of PTSD.2018
- Author(s)
  Jun Omura, Manabu Fuchikami, Motoaki Araki, Tatsuhiro Miyagi, Sigeru Morinobu
- Organizer
  第40回日本生物学的精神医学会・第61回日本神経化学会大会合同年会
- Data Source
  KAKENHI-PROJECT-18K07562
[Presentation] The role of glucocorticoid receptor in the induction and the prevention of the hippocampal abnormalities in an animal model of PTSD2018
- Author(s)
  Motoaki Araki, Manabu Fuchikami, Jun Omura, Tatsuhiro Miyagi, Nobuyuki Nagashima, Shigeru Morinobu, Yasumasa Okamoto
- Organizer
  Society for Neuroscience 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07562
[Presentation] こころの脳科学イノベーション　うつ病医療からモノづくりまで2017
- Author(s)
  山脇成人, 岡本泰昌, 岡田剛, 吉野敦雄, 淵上学, 岡田怜, 山下英尚, 町野彰彦, 志々田一宏, 小早川誠, 神人蘭
- Organizer
  第113回日本精神神経学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02552
[Presentation] PTSDモデルラットにおける恐怖記憶の消去障害に対する脳由来神経栄養因子Brain-Derived Neurotrophic Factor (BDNF) 脳局所投与の効果の検討2015
- Author(s)
  片岡努、淵上学、岡田怜、野嶌真士、長嶋信行、森信繁
- Organizer
  第45回日本神経精神薬理学会第37回日本生物学的精神医学会合同年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-26860928
[Presentation] PTSDモデルラットにおける恐怖記憶の消去障害に対する脳由来神経栄養因子Brain-Derived Neurotrophic Factor (BDNF) 脳局所投与の効果の検討
- Author(s)
  片岡努、淵上学、長嶋信行、野嶌真士、岡田怜、森信繁、山脇成人
- Organizer
  第37回日本生物学的精神医学会
- Place of Presentation
  タワーホール船堀　東京都江戸川区船堀
- Year and Date
  2015-09-24 – 2015-09-26
- Data Source
  KAKENHI-PROJECT-26860928

1. Morinobu Shigeru (30191042)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. Okada Go (10457286)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
3. Okamoto Yasumasa (70314763)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. IHARA Kazushige (10266083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Yamawaki Shigeto (40230601)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. Hashimoto Koichi (00303272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Morioka Norimitsu (20346505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Yamawaki Yosuke (90584061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Sakai Norio (70263407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉田英世 (00242735)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大渕修一 (50265740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 吉野敦雄 (90633727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 秀和泉 (20253073)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 田中茂 (20512651)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 白藤俊彦 (30595765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 太田茂 (60160503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 田尻直輝 (80782119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 津田雅之 (90406182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KATARAO kazusa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MURAKAWA seiya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ASANO masaya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MOTOIKE serika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. URABE tomoaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. HARADA kana

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 大森哲郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 石井一夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fuchikami Manabu 淵上 学

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腹側淡蒼球からみた適切な養育機会の欠損を経たうつ病の病態と治療法・予防法の研究Principal Investigator

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The development of the novel strategy for the prevention of PTSD, and of the novel treatment using neuromodulation.Principal Investigator

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The therapeutic potential of BDNF and epigenetic changes in the animal model of PTSD.Principal Investigator

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[Journal Article] Long-term mental health and resilience of the first responders in Japanese ground self-defense forces engaging body recovery after the great east Japan earthquake2024

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[Journal Article] Neonatal Isolation Increases the Susceptibility to Learned Helplessness through the Aberrant Neuronal Activity in the Ventral Pallidum of Rats2024

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[Journal Article] Chemogenetic activation of the mPFC alleviates impaired fear memory extinction in an animal model of PTSD2021

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Fuchikami Manabu 淵上学

[Presentation] こころの脳科学イノベーション　うつ病医療からモノづくりまで2017