Sawara Kei 佐原圭

… Alternative Names

SAWARA Kei 佐原圭

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Researcher Number	40405816
Affiliation (based on the past Project Information) *help	2017 – 2018: 岩手医科大学, 医学部, 非常勤医師 2015 – 2016: 岩手医科大学, 医学部, 助教 2015: 岩手医科大学, 内科学講座消化器内科肝臓分野, 助教 2009 – 2011: 岩手医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Gastroenterology Except Principal Investigator Gastroenterology
Keywords	Principal Investigator NPテスト / アンモニア / mean kurtosis (MK) / DKI / MRS / MRI / ミオイノシトール / グルタミン / カルニチン / ミニマル肝性脳症 … More Except Principal Investigator … More 肝性脳症 / アストロサイト / 血清遊離脂肪酸 / アンモニア / 肝硬変 / ミニマル肝性脳症 / カルニチン / 細胞・祖時期 / 薬物反応 / 肝炎ウイルス / シグナル伝達 / 細胞・組織 / 薬剤反応 / インターフェロン / ウイルス Less

Clinical study of pathogenic mechanism of minimal hepatic encephalopathy using ultra-high magnetic field 7 Tesla MRIPrincipal Investigator
- Principal Investigator
  
  SAWARA KEI
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Experimental and clinical studies on the effects of L-carnitine in minimal hepatic encephalopathy
- Principal Investigator
  
  Suzuki kazuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University
Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender
- Principal Investigator
  
  SUZUKI Kazuyuki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Iwate Medical University

All 2019 2018 2017 2016 2015 2014 2012 2011 2009 Other

All Journal Article Presentation Book

[Book] The Liver in Systemic Diseases, Chapter 5 The Brain and Liver2016
- Author(s)
  Kei Sawara,Hidekatu kuroda,Yasuhiro Takikawa
- Total Pages
  10
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K19346
[Book] 新しい診断と治療のABC 44「肝硬変」改訂第2版　第4章　管理・治療　薬物療法２．高アンモニア血腫治療の進歩2015
- Author(s)
  鈴木一幸、佐原圭、小岡洋平、吉田雄一、小野寺美緒、遠藤龍人、滝川康裕、加藤章信
- Total Pages
  11
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-25461009
[Book] 消化器疾患最新の治療2015-2016　［Ⅳ-A-10-b　反復性脳症］2015
- Author(s)
  佐原　圭
- Total Pages
  4
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-15K19346
[Journal Article] Decreased Mean Kurtosis in the Putamen is a Diagnostic Feature of Minimal Hepatic Encephalopathy in Patients with Cirrhosis2019
- Author(s)
  Sato Takuro、Endo Kei、Kakisaka Keisuke、Suzuki Yuji、Kooka Yohei、Sawara Kei、Ito Kenji、Sasaki Makoto、Takikawa Yasuhiro
- Journal Title
  
  Intern. Med.
  
  Volume: 58 Issue: 9 Pages: 1217-1224
- DOI
  10.2169/internalmedicine.2116-18
- NAID
  130007641555
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2019-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19346, KAKENHI-PROJECT-16K19520
[Journal Article] L-carnitine prevents ammonia-induced cytotoxicity and disturbances in intracellular amino acid levels in human astrocytes2018
- Author(s)
  Wang Ting、Suzuki Kazuyuki、Kakisaka Keisuke、Onodera Mio、Sawara Kei、Takikawa Yasuhiro
- Journal Title
  
  Journal of Gastroenterology and Hepatology
  
  Volume: - Issue: 7 Pages: 1249-1255
- DOI
  10.1111/jgh.14497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19346, KAKENHI-PROJECT-19K08475
[Journal Article] Updating the neuropsychological test system in Japan for the elderly and in a modern touch screen tablet society by resetting the cut-off values.2017
- Author(s)
  Kawaguchi T, Konishi M, Kato A, Kato M, Kooka Y, Sawara K, et.AL
- Journal Title
  
  Hepatol Research
  
  Volume: 47 Issue: 12 Pages: 1335-1339
- DOI
  10.1111/hepr.12864
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19346
[Journal Article] 高齢肝硬変患者の蛋白・エネルギー代謝異常の特徴2016
- Author(s)
  鈴木一幸、永井田優衣、佐原圭、遠藤啓、遠藤龍人、黒田英克、滝川康裕、加藤章信
- Journal Title
  
  日本高齢消化器病学会誌
  
  Volume: １８ Pages: 32-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461009
[Journal Article] 肝硬変におけるミニマル肝性脳症の合併率とその予測因子に関する検討：高齢者と非高齢者での健康2016
- Author(s)
  鈴木一幸、佐原圭、小岡洋平、黒田英克、遠藤龍人、滝川康裕、加藤章信
- Journal Title
  
  日本高齢消化器病学会誌
  
  Volume: １８ Pages: 58-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461009
[Journal Article] Brain metabolism in minimal hepatic encephalopathy assessed by 3.0-Tesla magnetic resonance spectroscopy2016
- Author(s)
  Kooka Yohei, Sawara Kei, Endo Rujin, Kato Akinobu, Suzuki Kazuyuki, Takikawa Yasuhiro.
- Journal Title
  
  Hepatol Reserch
  
  Volume: 46 Issue: 4 Pages: 269-76
- DOI
  10.1111/hepr.12519
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19346, KAKENHI-PROJECT-25461009
[Journal Article] Predictive biomarkers for diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis: A preliminary result in a single center study in Japan2016
- Author(s)
  Kazuyuki Suzuki、Hidekatsu Kuroda、Kei Sawara　et al.
- Journal Title
  
  Biomedical Research and Clinical Practice
  
  Volume: 1 Issue: 3 Pages: 97-102
- DOI
  10.15761/brcp.1000117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19346
[Journal Article] 肝硬変治療の進歩(4)分岐鎖アミノ酸製剤による治療効果2014
- Author(s)
  遠藤龍人、佐原　圭、遠藤　啓、滝川康裕、加藤章信、鈴木一幸
- Journal Title
  
  臨牀消化器内科
  
  Volume: 29 Pages: 447-452
- Open Access
- Data Source
  KAKENHI-PROJECT-25461009
[Journal Article] Effect　of　zinc　on　liver　cirrhosis　with　hyperammonemia:　A　preliminary　randomized,　placebo-controlled, double-blind trial2014
- Author(s)
  Katayama K, Saito M, Kawaguchi T, Endo R, Sawara K, Nishiguchi S, Kato A, Kohgo H, Suzuki K, Sakaida I, Ueno Y, Habu D, Ito T, Moriwaki H, Suzuki K
- Journal Title
  
  Nutrition
  
  Volume: 30 Pages: 1409-1419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461009
[Journal Article] 肝疾患　肝性脳症2014
- Author(s)
  鈴木一幸、佐原　圭、遠藤龍人、滝川康裕
- Journal Title
  
  日本臨牀　内科疾患にみられる神経障害（疾患）肝・腎・肺疾患
  
  Volume: 別冊 Pages: 350-353
- Open Access
- Data Source
  KAKENHI-PROJECT-25461009
[Journal Article] 肝疾患の栄養管理2014
- Author(s)
  遠藤龍人、佐原　圭、遠藤　啓、滝川康裕、鈴木一幸
- Journal Title
  
  臨牀消化器内科
  
  Volume: 29 Pages: 1119-1127
- Open Access
- Data Source
  KAKENHI-PROJECT-25461009
[Journal Article] Negative regulation of human astrocytes by IFNα: the involvement of growth inhibition and impaired glucose utilization2012
- Author(s)
  Wang T, Takikawa Y, Sawara K, Yoshida S, Suzuki K
- Journal Title
  
  Neurochem Res
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Therapeutic efficacy of combination therapy with intra-arterial 5-fluorouracil and systemic pegylated interferon a-2b for advanced hepatocellular carcinoma with portal venous invasion2011
- Author(s)
  Kasai K, Ushio A, Kasai Y, Sawara K, Miyamoto Y, Oikawa K, Kuroda H, Takikawa Y, Suzuki K
- Journal Title
  
  Cancer
  
  Volume: 118 Issue: 13 Pages: 3302-3310
- DOI
  10.1002/cncr.26648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Evaluation of newly developed combination therapy of intra-arterial 5-fluorouracil and systemic pegylated interferon alpha-2b for advanced hepatocellular carcinoma with portal venous invasion : preliminary results2009
- Author(s)
  Kasai K, Kuroda H, Ushio A, Sawara K, Takikawa Y, Suzuki K
- Journal Title
  
  Hepatol Res
  
  Volume: 39 Pages: 117-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Evaluation of newly developed combination therapy of intra-arterial 5-fluorouracil and systemic pegylated interferon alpha-2b for advanced hepatocellular carcinoma with portal venous invasion : preliminary results2009
- Author(s)
  Kasai K, Kuroda H, Ushio A, Sawara K, Takikawa Y, Suzuki K
- Journal Title
  
  Hepatol Res 39
  
  Pages: 117-125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure2009
- Author(s)
  Sawara K, Desjardins P, Chatauret N, Kato A, Suzuki K, Butterworth RF
- Journal Title
  
  Neurochem Int
  
  Volume: 55 Pages: 119-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Journal Article] Alterations in expression of genes coding for proteins of the neuro-vascular unit in ischemic liver failure.2009
- Author(s)
  Sawara K, Desjardings P, Chatauret N, Kato A, Suzuki K, Butterworth RF.
- Journal Title
  
  Neurochem Int 55
  
  Pages: 119-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] BRAIN METABOLISM IN PATIENTS WITH MINIMAL HEPATIC ENCEPHALOPATHY ON 3.0-TESLA MAGNETIC RESONANCE SPECTROSCOPY2017
- Author(s)
  Kei Sawara
- Organizer
  国際肝性脳症窒素代謝学会　　ISHEN 2017
- Place of Presentation
  インド　ニューデリー
- Year and Date
  2017-03-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19346
[Presentation] BRAIN METABOLISM IN PATIENTS WITH MINIMAL HEPATIC ENCEPHALOPATHY ON 3.0-TESLA MAGNETIC RESONANCE SPECTROSCOPY2015
- Author(s)
  Sawara Kei
- Organizer
  UEGW 2015
- Place of Presentation
  バルセロナ　スペイン
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-15K19346
[Presentation] L-carnitine prevents ammonia-induced cytotoxicity on human astrocytes: Results of metabolome analysis2015
- Author(s)
  Kazuyuki Suzuki, Ting Wang, Keisuke Kakisaka, Kei Sawara, Miho Onodera, Hidekatsu Kuroda, Ryujin Endo, Akinobu Kato, and Yasuhiro Takikawa
- Organizer
  ASSLD
- Place of Presentation
  Chicago, USA
- Year and Date
  2015-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461009
[Presentation] Interferon-α inhibits the proliferation of human astrocyte and decrease the expression glucose transporter Glut-12011
- Author(s)
  Wang T, Takikawa Y, Yoshida S, Sawara K, Suzuki K
- Organizer
  22^<st> APDW
- Place of Presentation
  Singapore, Malaysia
- Year and Date
  2011-10-07
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] Cerebral glucose metabolism and neuropsychiatric symptoms in chronic hepatitis C patients under antiviral therapy2011
- Author(s)
  Sawara K, Yoshida S, Oikawa A, Miyasaka A, Endo R, Takikawa Y, Kato A, Suzuki K
- Organizer
  21^<st> APASL
- Place of Presentation
  Bangkok, Thailand
- Year and Date
  2011-02-17
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] Cerebral glucose metabolism and neuropsychiatric symptoms in chronic hepatitis C patients under antiviral therapy2011
- Author(s)
  K Sawara, K Suzuki., et al., (8人中8番目)
- Organizer
  The Conference of the Asia Pacific Association for the Study of the Liver
- Place of Presentation
  バンコック(タイ)
- Data Source
  KAKENHI-PROJECT-21590857
[Presentation] 肝硬変におけるミニマル肝性脳症の罹患率とその診断的予測因子の検索
- Author(s)
  小野寺美緒、鈴木一幸、黒田英克、小岡洋平、佐原　圭、王　挺、及川隆喜、遠藤龍人、滝川康裕、加藤章信
- Organizer
  第51回日本肝臓学会総会
- Place of Presentation
  熊本市
- Year and Date
  2015-05-21 – 2015-05-22
- Data Source
  KAKENHI-PROJECT-25461009

1. WANG Tei (70416171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. SUZUKI Kazuyuki (00137499)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
3. TAKIKAWA Yasuhiro (50254751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. MIYASAKA Akio (80382597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Kakisaka Keisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. Kuroda Hidekatsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Kato Akinobu

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results

Sawara Kei 佐原 圭

SAWARA Kei 佐原 圭

Research Projects

Research Products

Co-Researchers

Clinical study of pathogenic mechanism of minimal hepatic encephalopathy using ultra-high magnetic field 7 Tesla MRIPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental and clinical studies on the effects of L-carnitine in minimal hepatic encephalopathy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Influence of interferon on the functional and structural changes of central nervous system from the viewpoints of aging and gender

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] The Liver in Systemic Diseases, Chapter 5 The Brain and Liver2016

Author(s)

Total Pages

Publisher

Data Source

[Book] 新しい診断と治療のABC 44「 肝硬変」改訂第2版 第4章 管理・治療 薬物療法２．高アンモニア血腫治療の進歩2015

Author(s)

Total Pages

Publisher

Data Source

[Book] 消化器疾患最新の治療2015-2016 ［Ⅳ-A-10-b 反復性脳症］2015

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Decreased Mean Kurtosis in the Putamen is a Diagnostic Feature of Minimal Hepatic Encephalopathy in Patients with Cirrhosis2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] L-carnitine prevents ammonia-induced cytotoxicity and disturbances in intracellular amino acid levels in human astrocytes2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Updating the neuropsychological test system in Japan for the elderly and in a modern touch screen tablet society by resetting the cut-off values.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 高齢肝硬変患者の蛋白・エネルギー代謝異常の特徴2016

Author(s)

Journal Title

Data Source

[Journal Article] 肝硬変におけるミニマル肝性脳症の合併率とその予測因子に関する検討：高齢者と非高齢者での健康2016

Author(s)

Journal Title

Data Source

[Journal Article] Brain metabolism in minimal hepatic encephalopathy assessed by 3.0-Tesla magnetic resonance spectroscopy2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predictive biomarkers for diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis: A preliminary result in a single center study in Japan2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 肝硬変治療の進歩(4)分岐鎖アミノ酸製剤による治療効果2014

Author(s)

Journal Title

Data Source

[Journal Article] Effect of zinc on liver cirrhosis with hyperammonemia: A preliminary randomized, placebo-controlled, double-blind trial2014

Sawara Kei 佐原圭

SAWARA Kei 佐原圭

[Book] 新しい診断と治療のABC 44「肝硬変」改訂第2版　第4章　管理・治療　薬物療法２．高アンモニア血腫治療の進歩2015

[Book] 消化器疾患最新の治療2015-2016　［Ⅳ-A-10-b　反復性脳症］2015

[Journal Article] Effect　of　zinc　on　liver　cirrhosis　with　hyperammonemia:　A　preliminary　randomized,　placebo-controlled, double-blind trial2014

[Journal Article] 肝疾患　肝性脳症2014